Max Planck Institute for molecular genetics
The model reproduces the time profiles of Total Smad2 in the nucleus as well as the cytoplasm as depicted in 2D and also the other time profiles as depicted in Fig 2. Two parameters that are not present in the paper are introduced here for illustration purposes and they are Total Smad2n and Total Smad2c. The term kr_EE*LRC_EE has not been included in the ODE's for T1R_surf, T2R_surf and TGFbeta in the paper but is included in this model. MathSBML was used to reproduce the simulation result. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Beijing National Laboratory for Molecular Sciences