BIOMD0000000158
type: SBMLModel
reaction: metaid_0000014
parameter: metaid_0000005
reaction: metaid_0000024
length unit: length
units def: metaid_0000020
name: Zatorsky2006_p53_Model2
parameter: metaid_0000025
is part of: GO:0042771
parameter: metaid_0000008
parameter: metaid_0000032
reaction: metaid_0000018
units def: metaid_0000019
species: metaid_0000011
parameter: metaid_0000029
occurs in: http://identifiers.org/taxonomy/9606
reaction: metaid_0000015
compartment: metaid_0000009
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
event: metaid_0000034
parameter: metaid_0000006
rule: metaid_0000027
parameter: metaid_0000030
is part of: hsa04115
is: MODEL0076306022
parameter: metaid_0000023
parameter: metaid_0000033
reaction: metaid_0000016
substance units: metaid_0000019
parameter: metaid_0000003
is described by: http://identifiers.org/pubmed/16773083
reaction: metaid_0000013
parameter: metaid_0000004
curated: true
event: metaid_0000035
created:
  W3 CDTF: Thu Jan 10 17:38:04 GMT 2008
volume units: metaid_0000084
notes: The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 2. Results obtained using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000007
time units: metaid_0000020
area units: metaid_0000005
species: metaid_0000012
parameter: metaid_0000031
parameter: metaid_0000028
modified:
  W3 CDTF: Thu Jul 05 15:41:12 BST 2012
species: metaid_0000022

metaid_0000014
type: Reaction
kinetic law: 664819
reactant: 664807
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 independent p53 degradation

664807
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
is version of: P04637
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.28
initial amount: NaN
in compartment: metaid_0000009
name: p53

metaid_0000009
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000005
type: Parameter
constant: true
value: 0.0

metaid_0000024
type: Reaction
kinetic law: 664952
reactant: 664939
is version of: GO:0044257
fast: false
reversible: true
name: Mdm2 degradation

664939
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000012
type: Species
is version of: Q00987
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.73
initial amount: NaN
in compartment: metaid_0000009
name: Mdm2

metaid_0000020
type: SBMLUnitsDef
unit: 664771
name: hours

664771
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

metaid_0000025
type: Parameter
constant: false
value: 0.0

metaid_0000008
type: Parameter
constant: true
value: 0.6

metaid_0000032
type: Parameter
constant: false
value: 0.92

metaid_0000018
type: Reaction
kinetic law: 664928
product: 664915
reactant: 664904
is version of: GO:0006412
fast: false
reversible: false
name: Mdm2 synthesis from precursor

664915
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

664904
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000009
name: precursor Mdm2

metaid_0000019
type: SBMLUnitsDef
unit: 664760
name: dimensionless

664760
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000029
type: Parameter
constant: false
value: 0.0

metaid_0000015
type: Reaction
kinetic law: 664856
modifier: 664843
reactant: 664831
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 dependent p53 degradation

664831
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000034
type: Event
event assignment: 664999
event assignment: 664988
event assignment: 664975
trigger: 664963
use values from trigger time: true

metaid_0000030
type: Parameter
constant: false
value: 1.0

metaid_0000028
type: Parameter
constant: false
value: 0.0

664963
type: Trigger
persistant: true
initial value: true

metaid_0000006
type: Parameter
constant: true
value: 3.15

metaid_0000023
type: Parameter
constant: true
value: 55.0

metaid_0000033
type: Parameter
constant: false
value: 0.12

metaid_0000016
type: Reaction
kinetic law: 664891
modifier: 664880
product: 664867
is version of: GO:0006351
fast: false
reversible: false
name: p53 dependent Mdm2 precursor production

664867
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000003
type: Parameter
constant: true
value: 2.55

metaid_0000013
type: Reaction
kinetic law: 664795
product: 664783
is version of: GO:0006412
fast: false
reversible: false
name: p53 production

664783
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000004
type: Parameter
constant: true
value: 1.0

metaid_0000035
type: Event
event assignment: 665049
event assignment: 665037
event assignment: 665025
trigger: 665012
use values from trigger time: true

665012
type: Trigger
persistant: true
initial value: true

metaid_0000007
type: Parameter
constant: true
value: 0.85

metaid_0000031
type: Parameter
constant: true
value: 34.0