BIOMD0000000157
type: SBMLModel
reaction: metaid_0000016
is described by: http://identifiers.org/pubmed/16773083
parameter: metaid_0000004
units def: metaid_0000019
is: MODEL0076360248
parameter: metaid_0000005
reaction: metaid_0000018
created:
  W3 CDTF: Thu Jan 10 17:38:04 GMT 2008
species: metaid_0000011
notes: The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 4. Results obtained using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000007
occurs in: http://identifiers.org/taxonomy/9606
modified:
  W3 CDTF: Thu Jul 05 15:42:09 BST 2012
substance units: metaid_0000019
parameter: metaid_0000023
parameter: metaid_0000008
compartment: metaid_0000009
volume units: metaid_0000084
units def: metaid_0000020
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
parameter: metaid_0000025
time units: metaid_0000020
reaction: metaid_0000024
parameter: metaid_0000026
species: metaid_0000022
length unit: length
is part of: hsa04115
species: metaid_0000012
reaction: metaid_0000013
reaction: metaid_0000015
reaction: metaid_0000014
curated: true
is part of: GO:0042771
parameter: metaid_0000003
name: Zatorsky2006_p53_Model4
area units: metaid_0000005

metaid_0000016
type: Reaction
kinetic law: 721892
modifier: 721880
product: 721868
is version of: GO:0006351
fast: false
reversible: false
name: p53 dependent Mdm2 precursor production

metaid_0000011
type: Species
is version of: P04637
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000009
name: p53

metaid_0000009
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

721868
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000009
name: precursor Mdm2

metaid_0000004
type: Parameter
constant: true
value: 1.0

metaid_0000019
type: SBMLUnitsDef
unit: 721760
name: dimensionless

721760
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000005
type: Parameter
constant: true
value: 0.0

metaid_0000018
type: Reaction
kinetic law: 721929
product: 721917
reactant: 721904
is version of: GO:0006412
fast: false
reversible: false
name: Mdm2 synthesis from precursor

721917
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000012
type: Species
is version of: Q00987
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.8
initial amount: NaN
in compartment: metaid_0000009
name: Mdm2

721904
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000007
type: Parameter
constant: true
value: 1.1

metaid_0000023
type: Parameter
constant: true
value: 0.8

metaid_0000008
type: Parameter
constant: true
value: 0.8

metaid_0000020
type: SBMLUnitsDef
unit: 721772
name: hours

721772
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

metaid_0000025
type: Parameter
constant: true
value: 1.0E-4

metaid_0000024
type: Reaction
kinetic law: 721953
reactant: 721941
is version of: GO:0044257
fast: false
reversible: true
name: Mdm2 degradation

721941
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000026
type: Parameter
constant: true
value: 1.7

metaid_0000013
type: Reaction
kinetic law: 721796
product: 721784
is version of: GO:0006412
fast: false
reversible: false
name: p53 production

721784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000015
type: Reaction
kinetic law: 721856
modifier: 721844
reactant: 721833
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 dependent p53 degradation

721833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000014
type: Reaction
kinetic law: 721820
reactant: 721808
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 independent p53 degradation

721808
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000003
type: Parameter
constant: true
value: 0.9