BIOMD0000000156
type: SBMLModel
parameter: metaid_0000005
curated: true
units def: metaid_0000020
parameter: metaid_0000006
parameter: metaid_0000007
species: metaid_0000011
substance units: metaid_0000019
volume units: metaid_0000084
parameter: metaid_0000008
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
reaction: metaid_0000013
is: MODEL0076384106
is part of: hsa04115
parameter: metaid_0000025
reaction: metaid_0000015
modified:
  W3 CDTF: Thu Jul 05 15:44:40 BST 2012
occurs in: http://identifiers.org/taxonomy/9606
reaction: metaid_0000016
notes: The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 5. Results obtained using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000022
time units: metaid_0000020
name: Zatorsky2006_p53_Model5
is part of: GO:0042771
area units: metaid_0000005
parameter: metaid_0000023
is described by: http://identifiers.org/pubmed/16773083
reaction: metaid_0000018
species: metaid_0000012
compartment: metaid_0000009
reaction: metaid_0000024
parameter: metaid_0000004
units def: metaid_0000019
length unit: length
created:
  W3 CDTF: Thu Jan 10 17:38:04 GMT 2008

metaid_0000005
type: Parameter
constant: true
value: 0.0

metaid_0000020
type: SBMLUnitsDef
unit: 842520
name: hours

842520
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

metaid_0000006
type: Parameter
constant: true
value: 3.7

metaid_0000007
type: Parameter
constant: true
value: 1.5

metaid_0000011
type: Species
is version of: P04637
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.02
initial amount: NaN
in compartment: metaid_0000009
name: p53

metaid_0000009
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000019
type: SBMLUnitsDef
unit: 842507
name: dimensionless

842507
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000008
type: Parameter
constant: true
value: 0.9

metaid_0000013
type: Reaction
kinetic law: 842545
product: 842533
is version of: GO:0006412
fast: false
reversible: false
name: p53 production

842533
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000025
type: Parameter
constant: true
value: 2.0

metaid_0000015
type: Reaction
kinetic law: 842582
modifier: 842570
reactant: 842557
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 dependent p53 degradation

metaid_0000012
type: Species
is: Q00987
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.2
initial amount: NaN
in compartment: metaid_0000009
name: Mdm2

842557
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000016
type: Reaction
kinetic law: 842620
modifier: 842607
product: 842595
is version of: GO:0006351
fast: false
reversible: false
name: p53 dependent Mdm2 precursor production

842595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000009
name: precursor Mdm2

metaid_0000023
type: Parameter
constant: true
value: 1.1

metaid_0000018
type: Reaction
kinetic law: 842659
product: 842646
reactant: 842633
is version of: GO:0006412
fast: false
reversible: false
name: Mdm2 synthesis from precursor

842646
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

842633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000024
type: Reaction
kinetic law: 842685
reactant: 842672
is version of: GO:0044257
fast: false
reversible: true
name: Mdm2 degradation

842672
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000004
type: Parameter
constant: true
value: 1.0