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427185
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427161
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metaid_0000019
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metaid_0000003
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427149
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metaid_0000127
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427137
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metaid_0000125
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426415
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426391
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426367
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metaid_0000067
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423755
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423731
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metaid_0000005
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423719
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423707
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metaid_0000100
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425232
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metaid_0000045
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425256
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425208
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metaid_0000098
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425220
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metaid_0000023
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metaid_0000244
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metaid_0000236
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429004
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metaid_0000161
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metaid_0000070
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423935
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423911
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423899
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423887
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metaid_0000063
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metaid_0000049
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metaid_0000036
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422672
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422648
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metaid_0000014
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422636
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422624
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metaid_0000178
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428426
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428402
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428390
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metaid_0000177
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428378
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metaid_0000174
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metaid_0000153
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427521
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427497
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427485
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427473
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metaid_0000128
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metaid_0000147
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427233
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427209
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427197
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metaid_0000089
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424740
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424776
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424752
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424728
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metaid_0000122
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426295
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426271
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426259
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426247
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metaid_0000068
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423815
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423791
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423779
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423767
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metaid_0000101
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425316
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425292
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425280
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metaid_0000034
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425268
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metaid_0000245
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429029
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metaid_0000085
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424596
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424572
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424560
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424548
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metaid_0000083
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metaid_0000137
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metaid_0000017
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422012
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421988
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421976
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metaid_0000004
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421964
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metaid_0000015
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metaid_0000025
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metaid_0000012
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421832
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421808
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421796
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421784
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metaid_0000006
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metaid_0000175
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428305
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428281
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428268
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428255
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metaid_0000166
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metaid_0000251
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428956
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metaid_0000051
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423094
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423070
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423058
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423046
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metaid_0000041
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metaid_0000241
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428908
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metaid_0000171
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428123
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428099
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428087
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metaid_0000164
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428075
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metaid_0000165
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metaid_0000190
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metaid_0000133
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metaid_0000129
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426475
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426451
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metaid_0000126
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426439
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426427
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metaid_0000044
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422973
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422949
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stoichiometry: 1.0
species: metaid_0000047

metaid_0000047
type: Species
has only substance units: false
name: D75_PP2A
boundary condition: false
has part: Q9UD71
has part: IPR006186
in compartment: metaid_0000003
constant: false
initial amount: NaN
initial concentration: 0.0

422936
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

422924
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000256
type: Event
event assignment: 429281
trigger: 429269
use values from trigger time: true
name: ca_off6

429269
type: Trigger
persistant: true
initial value: true

metaid_0000138
type: Species
initial concentration: 0.0
initial amount: NaN
name: CK1P_PP2B
has part: PIRSF000911
has only substance units: false
constant: false
has part: Q99PS2
boundary condition: false
in compartment: metaid_0000003

metaid_0000013
type: Reaction
name: DPhospho_by_CDK5_on_75
is version of: GO:0004693
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.22
kinetic law: 421880
reactant: 421844
reversible: false
product: 421856
product: 421868

421892
type: LocalParameter
value: 3.0
name: kcat1

421844
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

421856
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

421868
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000027
type: Reaction
kinetic law: 422360
product: 422348
reactant: 422336
reactant: 422324
is version of: GO:0019901
fast: false
reversible: false
name: D34_CK1_binding

422372
type: LocalParameter
value: 4400000.0
name: kon5

422348
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

422336
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

422324
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000159
type: Reaction
is version of: GO:0030552
reactant: 427726
product: 427738
reversible: false
fast: false
is version of: GO:0034237
kinetic law: 427750
reactant: 427714
name: R2C2_cAMP_binding

427726
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

427738
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000162
type: Species
constant: false
has part: PIRSF000548
boundary condition: false
has part: CHEBI:17489
initial amount: NaN
initial concentration: 0.0
name: cAMP_R2C2
in compartment: metaid_0000003
has part: PIRSF000582
has only substance units: false
is version of: GO:0043234

427762
type: LocalParameter
value: 5.4E7
name: kon37

427714
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

metaid_0000160
type: Species
has part: PIRSF000548
boundary condition: false
constant: false
initial amount: NaN
in compartment: metaid_0000003
has part: PIRSF000582
initial concentration: 6.64E-6
has only substance units: false
is version of: GO:0043234
name: R2C2

metaid_0000130
type: Reaction
reactant: 426487
kinetic law: 426523
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 426511
name: D75:137_dephospho_by_PP2C_137
reversible: false
fast: false
is version of: GO:0004722
product: 426499

426487
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

426535
type: LocalParameter
value: 3.0
name: kcat24

426511
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426499
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000074
type: Species
in compartment: metaid_0000003
has part: Q9UD71
initial concentration: 0.0
initial amount: NaN
has only substance units: false
name: D34:75_CK1
boundary condition: false
has part: Q99PS2
constant: false

metaid_0000139
type: Reaction
kinetic law: 426884
product: 426872
product: 426860
reactant: 426848
fast: false
reversible: false
name: CK1P_PP2B_unbinding

426896
type: LocalParameter
value: 24.0
name: koff29

426872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

426860
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

426848
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000113
type: Reaction
kinetic law: 425862
product: 425850
product: 425838
reactant: 425826
fast: false
reversible: false
name: D34:75_PP2AP_unbinding

425874
type: LocalParameter
value: 40.0
name: koff16

425850
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

425838
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

425826
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

metaid_0000111
type: Species
initial amount: NaN
constant: false
has part: Q9UD71
name: D34:75_PP2AP
boundary condition: false
has part: IPR006186
in compartment: metaid_0000003
has only substance units: false
initial concentration: 0.0

metaid_0000173
type: Reaction
fast: false
reactant: 428195
name: cAMP4_R2C_PKA_binding
is version of: GO:0034237
is version of: GO:0034236
product: 428219
reactant: 428207
reversible: false
kinetic law: 428231

428195
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000174

428219
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

428207
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

428243
type: LocalParameter
value: 1.8E7
name: kon41

metaid_0000105
type: Reaction
kinetic law: 425486
product: 425474
product: 425462
reactant: 425450
fast: false
reversible: false
name: D75:137_PP2A_unbinding

425498
type: LocalParameter
value: 24.0
name: koff22

425474
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425462
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

425450
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

metaid_0000103
type: Species
initial concentration: 0.0
has part: IPR006186
in compartment: metaid_0000003
constant: false
has part: Q9UD71
boundary condition: false
has only substance units: false
initial amount: NaN
name: D75:137_PP2A

metaid_0000062
type: Reaction
kinetic law: 423623
product: 423611
reactant: 423599
reactant: 423587
is version of: GO:0034236
fast: false
reversible: false
name: D137_PKA_binding

423635
type: LocalParameter
value: 5600000.0
name: kon12

423611
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

423599
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

423587
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000096
type: Reaction
kinetic law: 425064
product: 425052
product: 425040
reactant: 425028
fast: false
reversible: false
name: D34:75:137_PP2B_unbinding

425076
type: LocalParameter
value: 120.0
name: koff27

425052
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

425040
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000080
type: Species
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D34:75:137

425028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000094
type: Species
name: D34:75:137_PP2B
has only substance units: false
has part: Q9UD71
constant: false
boundary condition: false
in compartment: metaid_0000003
initial amount: NaN
initial concentration: 0.0
has part: PIRSF000911

metaid_0000135
type: Reaction
kinetic law: 426764
product: 426752
product: 426740
reactant: 426728
fast: false
reversible: false
name: D34:75:137_PP2C_unbinding

426776
type: LocalParameter
value: 12.0
name: koff28

426752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

426728
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

metaid_0000050
type: Species
boundary condition: false
in compartment: metaid_0000003
initial concentration: 0.0
has only substance units: false
constant: false
has part: IPR006186
initial amount: NaN
has part: Q9UD71
name: D75_PP2AP

metaid_0000114
type: Reaction
kinetic law: 425923
product: 425910
reactant: 425898
reactant: 425886
is version of: GO:0051721
fast: false
reversible: false
name: D75:137_PP2AP_binding

425935
type: LocalParameter
value: 1.7E7
name: kon23

425910
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000115
type: Species
name: D75:137_PP2AP
in compartment: metaid_0000003
constant: false
has part: Q9UD71
boundary condition: false
initial concentration: 0.0
has part: IPR006186
has only substance units: false
initial amount: NaN

425898
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

425886
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000042
type: Reaction
kinetic law: 422900
product: 422888
reactant: 422876
reactant: 422864
is version of: GO:0034236
fast: false
reversible: false
name: D75_PKA_binding

422912
type: LocalParameter
value: 5600000.0
name: kon8

422888
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000043
type: Species
in compartment: metaid_0000003
initial concentration: 0.0
has part: PIRSF000582
name: D75_PKA
boundary condition: false
initial amount: NaN
has part: Q9UD71
constant: false
has only substance units: false

422876
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

422864
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000056
type: Reaction
reversible: false
is version of: GO:0004722
product: 423299
reactant: 423287
kinetic law: 423323
name: D75_dephospho_by_PP2A
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 423311
fast: false

423299
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

423287
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

423335
type: LocalParameter
value: 10.0
name: kcat9

423311
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000156
type: Reaction
kinetic law: 427569
product: 427557
reactant: 427545
reactant: 427533
is version of: GO:0005509
fast: false
reversible: false
name: PP2B_activation

427581
type: LocalParameter
value: 3.0E15
name: kon36

427557
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

427545
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000154

427533
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000030
type: Species
has only substance units: false
in compartment: metaid_0000003
initial concentration: 0.0
initial amount: NaN
boundary condition: false
has part: Q9UD71
has part: PIRSF000911
name: D34_PP2B
constant: false

metaid_0000167
type: Reaction
reactant: 427834
is version of: GO:0030552
reversible: false
kinetic law: 427870
is version of: GO:0034237
reactant: 427846
name: cAMP2_R2C2_binding_by_cAMP
product: 427858
fast: false

427834
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000164

427882
type: LocalParameter
value: 7.5E7
name: kon39

427846
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

427858
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

metaid_0000142
type: Reaction
kinetic law: 427052
product: 427040
reactant: 427028
reactant: 427016
is version of: GO:0034236
fast: false
reversible: false
name: PDE_PKA_binding

427064
type: LocalParameter
value: 6000000.0
name: kon31

427040
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

427028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

427016
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000259
type: Event
event assignment: 429353
trigger: 429341
use values from trigger time: true
name: ca_off9

429341
type: Trigger
persistant: true
initial value: true

metaid_0000078
type: Reaction
kinetic law: 424283
product: 424271
product: 424259
reactant: 424247
fast: false
reversible: false
name: D34:75_CK1_unbinding

424295
type: LocalParameter
value: 12.0
name: koff14

424271
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

424259
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

424247
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000057
type: Reaction
kinetic law: 423383
product: 423371
product: 423359
reactant: 423347
fast: false
reversible: false
name: D75_PP2A_unbinding

423395
type: LocalParameter
value: 24.0
name: koff9

423371
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

423359
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

423347
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000150
type: Reaction
kinetic law: 427341
product: 427329
product: 427317
reactant: 427305
fast: false
reversible: false
name: PP2A_PKA_unbinding

427353
type: LocalParameter
value: 16.0
name: koff33

427329
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

427317
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

427305
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

metaid_0000149
type: Species
constant: false
has part: IPR006186
boundary condition: false
initial amount: NaN
has part: PIRSF000582
has only substance units: false
in compartment: metaid_0000003
initial concentration: 0.0
name: PP2A_PKA

metaid_0000117
type: Reaction
kinetic law: 426043
product: 426031
product: 426019
reactant: 426007
fast: false
reversible: false
name: D75:137_PP2AP_unbinding

426055
type: LocalParameter
value: 40.0
name: koff23

426031
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

426019
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

426007
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000032
type: Reaction
kinetic law: 422480
product: 422468
product: 422456
reactant: 422444
is version of: GO:0019901
fast: false
reversible: false
name: D34_CDK5_unbinding

422492
type: LocalParameter
value: 12.0
name: koff4

422468
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

422456
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

422444
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000107
type: Species
has part: IPR006186
has only substance units: false
in compartment: metaid_0000003
initial concentration: 0.0
boundary condition: false
name: D34:75:137_PP2A
has part: Q9UD71
constant: false
initial amount: NaN

metaid_0000026
type: Reaction
kinetic law: 422300
product: 422288
reactant: 422276
reactant: 422264
is version of: GO:0019901
fast: false
reversible: false
name: D34_CDK5_binding

422312
type: LocalParameter
value: 5600000.0
name: kon4

422288
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

422276
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

422264
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000132
type: Reaction
kinetic law: 426643
product: 426631
reactant: 426619
reactant: 426607
is version of: GO:0019903
fast: false
reversible: false
name: D34:75:137_PP2C_binding

426655
type: LocalParameter
value: 7500000.0
name: kon28

426631
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

426619
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426607
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000262
type: Parameter
constant: true
value: 50.0
name: cAMP_Ca_delay

metaid_0000255
type: Event
event assignment: 429257
trigger: 429245
use values from trigger time: true
name: ca_off5

429245
type: Trigger
persistant: true
initial value: true

metaid_0000040
type: Reaction
kinetic law: 422840
product: 422828
reactant: 422816
reactant: 422804
is version of: GO:0019901
fast: false
reversible: false
name: D75_CK1_binding

422852
type: LocalParameter
value: 4400000.0
name: kon7

422828
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

422816
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

422804
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000250
type: Event
event assignment: 429161
trigger: 429149
use values from trigger time: true
name: ca_on10

429149
type: Trigger
persistant: true
initial value: true

metaid_0000118
type: Reaction
product: 426079
is version of: GO:0004722
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.16
name: D34:75:137_dephospho_by_PP2AP_on 75
reversible: false
reactant: 426067
product: 426091
kinetic law: 426103

426079
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

426067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000119
type: Species
in compartment: metaid_0000003
name: D34:75:137_PP2AP
boundary condition: false
has only substance units: false
has part: Q9UD71
constant: false
has part: IPR006186
initial concentration: 0.0
initial amount: NaN

426091
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

426115
type: LocalParameter
value: 24.0
name: kcat26

metaid_0000054
type: Reaction
kinetic law: 423203
product: 423191
product: 423179
reactant: 423167
is version of: http://identifiers.org/ec-code/2.7.11.11
fast: false
reversible: false
name: D75_Phospho_by_PKA_on_34

423215
type: LocalParameter
value: 0.0
name: kcat8

423191
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

423179
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

423167
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000033
type: Reaction
product: 422516
name: D34_Phospho_by_CDK5_on_75
is version of: GO:0004693
kinetic law: 422540
is version of: http://identifiers.org/ec-code/2.7.11.22
fast: false
reversible: false
product: 422528
reactant: 422504

422516
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

422552
type: LocalParameter
value: 3.0
name: kcat4

422528
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

422504
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000181
type: Reaction
kinetic law: 428536
product: 428523
product: 428511
reactant: 428499
fast: false
reversible: false
name: cAMP_PDE_unbinding

428548
type: LocalParameter
value: 40.0
name: koff44

428523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

428511
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

428499
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

metaid_0000180
type: Species
in compartment: metaid_0000003
boundary condition: false
has part: IPR000396
constant: false
has part: CHEBI:17489
has only substance units: false
name: cAMP_PDE
initial concentration: 0.0
initial amount: NaN

metaid_0000168
type: Reaction
fast: false
product: 427918
name: cAMP3_R2C2_binding_by_cAMP
is version of: GO:0034237
reactant: 427906
reversible: false
reactant: 427894
is version of: GO:0030552
kinetic law: 427930

427918
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

427906
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

427894
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

427942
type: LocalParameter
value: 7.5E7
name: kon40

metaid_0000140
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 426920
reactant: 426908
name: CK1P_dephospho_by_PP2B
is version of: GO:0033192
product: 426932
kinetic law: 426944
reversible: false
fast: false

426920
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

426908
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

426932
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

426956
type: LocalParameter
value: 6.0
name: kcat29

metaid_0000016
type: Reaction
kinetic law: 422060
product: 422048
product: 422036
reactant: 422024
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D_Phospho_by_CK1_on_137

422072
type: LocalParameter
value: 3.0
name: kcat2

422048
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

422036
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

422024
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000179
type: Reaction
kinetic law: 428474
product: 428462
reactant: 428450
reactant: 428438
is version of: GO:0030552
fast: false
reversible: false
name: cAMP_PDE_binding

428486
type: LocalParameter
value: 2520000.0
name: kon44

428462
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

428450
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

428438
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

metaid_0000075
type: Reaction
kinetic law: 424163
product: 424151
reactant: 424139
reactant: 424127
is version of: GO:0019901
fast: false
reversible: false
name: D34:137_CDK5_binding

424175
type: LocalParameter
value: 5600000.0
name: kon18

424151
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000076
type: Species
boundary condition: false
has only substance units: false
has part: Q03114
name: D34:137_CDK5
has part: Q9UD71
initial amount: NaN
initial concentration: 0.0
in compartment: metaid_0000003
constant: false

424139
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

424127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000008
type: Reaction
kinetic law: 421760
product: 421748
reactant: 421736
reactant: 421724
is version of: GO:0019901
fast: false
reversible: false
name: D_CDK5_binding

421772
type: LocalParameter
value: 5600000.0
name: kon1

421748
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

421736
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

421724
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000183
type: Species
is: CHEBI:16027
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: AMP

metaid_0000071
type: Reaction
name: D137_dephospho_by_PP2C
reversible: false
product: 423959
is version of: GO:0004722
kinetic law: 423983
fast: false
product: 423971
reactant: 423947
is version of: http://identifiers.org/ec-code/3.1.3.16

423959
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

423995
type: LocalParameter
value: 3.0
name: kcat13

423971
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

423947
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000065
type: Species
has part: IPR015655
in compartment: metaid_0000003
initial amount: NaN
boundary condition: false
initial concentration: 0.0
has part: Q9UD71
name: D137_PP2C
constant: false
has only substance units: false

metaid_0000069
type: Reaction
kinetic law: 423863
product: 423851
product: 423839
reactant: 423827
fast: false
reversible: false
name: D137_PKA_unbinding

423875
type: LocalParameter
value: 10.8
name: koff12

423851
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

423839
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

423827
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000102
type: Reaction
kinetic law: 425365
product: 425353
reactant: 425341
reactant: 425328
is version of: GO:0051721
fast: false
reversible: false
name: D75:137_PP2A_binding

425377
type: LocalParameter
value: 3800000.0
name: kon22

425353
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

425341
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425328
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000246
type: Event
event assignment: 429065
trigger: 429053
use values from trigger time: true
name: ca_on6

429053
type: Trigger
persistant: true
initial value: true

metaid_0000169
type: Reaction
kinetic law: 427990
product: 427978
product: 427966
reactant: 427954
fast: false
reversible: false
name: cAMP_R2C2_unbinding

428002
type: LocalParameter
value: 33.0
name: koff37

427978
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

427966
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

427954
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000108
type: Reaction
name: D34:75:137_dephospho_by_PP2A_on_75
product: 425585
kinetic law: 425611
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 425573
is version of: GO:0004722
reversible: false
product: 425598

425585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

425624
type: LocalParameter
value: 10.0
name: kcat25

425573
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

425598
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000038
type: Reaction
fast: false
kinetic law: 422720
reversible: false
is version of: GO:0033192
reactant: 422684
product: 422708
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 422696
name: D34_Dephospho_by_PP2B

422732
type: LocalParameter
value: 4.0
name: kcat6

422684
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

422708
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

422696
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000144
type: Reaction
product: 427101
fast: false
product: 427088
kinetic law: 427113
is version of: GO:0004691
reversible: false
reactant: 427076
is version of: http://identifiers.org/ec-code/2.7.11.11
name: PDE_phospho_by_PKA

427101
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

427088
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

427125
type: LocalParameter
value: 9.0
name: kcat31

427076
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

metaid_0000052
type: Reaction
kinetic law: 423143
product: 423130
product: 423118
reactant: 423106
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D75_Phospho_by_CK1_on_137

423155
type: LocalParameter
value: 3.0
name: kcat7

423130
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

423118
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

423106
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000059
type: Reaction
kinetic law: 423503
product: 423491
product: 423479
reactant: 423467
fast: false
reversible: false
name: D75_PP2AP_unbinding

423515
type: LocalParameter
value: 40.0
name: koff10

423491
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

423479
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

423467
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000242
type: Event
event assignment: 428944
trigger: 428932
use values from trigger time: true
name: ca_on2

428932
type: Trigger
persistant: true
initial value: true

metaid_0000039
type: Reaction
kinetic law: 422780
product: 422768
product: 422756
reactant: 422744
fast: false
reversible: false
name: D34_PP2B_unbinding

422792
type: LocalParameter
value: 16.0
name: koff6

422768
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

422756
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

422744
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000247
type: Event
event assignment: 429089
trigger: 429077
use values from trigger time: true
name: ca_on7

429077
type: Trigger
persistant: true
initial value: true

metaid_0000176
type: Reaction
reactant: 428330
reversible: false
kinetic law: 428354
fast: false
is version of: GO:0034236
is version of: GO:0034237
product: 428342
reactant: 428317
name: cAMP4_R2_PKA_binding

428330
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

428366
type: LocalParameter
value: 1.8E7
name: kon42

428342
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000174

428317
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000177

metaid_0000086
type: Reaction
kinetic law: 424644
product: 424632
reactant: 424620
reactant: 424608
is version of: GO:0030346
fast: false
reversible: false
name: D34:75_PP2B_binding

424656
type: LocalParameter
value: 1.0E7
name: kon17

424632
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

424620
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424608
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000109
type: Reaction
kinetic law: 425677
product: 425664
product: 425650
reactant: 425637
fast: false
reversible: false
name: D34:75:137_PP2A_unbinding

425690
type: LocalParameter
value: 24.0
name: koff25

425664
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425650
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

425637
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

W3 CDTF: Tue Mar 28 16:55:39 BST 2006

metaid_0000104
type: Reaction
product: 425413
product: 425401
reversible: false
is version of: GO:0004722
reactant: 425389
name: D75:137_dephospho_by_PP2A_on_75
kinetic law: 425426
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false

425413
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425401
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

425389
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

425438
type: LocalParameter
value: 10.0
name: kcat22

metaid_0000120
type: Reaction
kinetic law: 426163
product: 426151
reactant: 426139
reactant: 426127
is version of: GO:0051721
fast: false
reversible: false
name: D34:75:137_PP2AP_binding

426175
type: LocalParameter
value: 1.7E7
name: kon26

426151
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

426139
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

426127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000243
type: Event
event assignment: 428992
trigger: 428980
use values from trigger time: true
name: Ca_on3

428980
type: Trigger
persistant: true
initial value: true

metaid_0000131
type: Reaction
kinetic law: 426583
product: 426571
product: 426559
reactant: 426547
fast: false
reversible: false
name: D75:137_PP2C_unbinding

426595
type: LocalParameter
value: 12.0
name: koff24

426571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426559
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

426547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

metaid_0000035
type: Reaction
kinetic law: 422600
product: 422588
product: 422576
reactant: 422564
fast: false
reversible: false
name: D34_CK1_unbinding

422612
type: LocalParameter
value: 12.0
name: koff5

422588
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

422576
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

422564
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000258
type: Event
event assignment: 429329
trigger: 429317
use values from trigger time: true
name: ca_off8

429317
type: Trigger
persistant: true
initial value: true

metaid_0000152
type: Reaction
kinetic law: 427449
product: 427437
reactant: 427425
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: PP2AP_dephospho

427461
type: LocalParameter
value: 5.0
name: kcat34

427437
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

427425
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000106
type: Reaction
kinetic law: 425547
product: 425534
reactant: 425522
reactant: 425510
is version of: GO:0051721
fast: false
reversible: false
name: D34:75:137_PP2A_binding

425560
type: LocalParameter
value: 3800000.0
name: kon25

425534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

425522
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425510
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000021
type: Reaction
kinetic law: 422120
product: 422108
reactant: 422096
reactant: 422084
is version of: GO:0034236
fast: false
reversible: false
name: D_PKA_binding

422132
type: LocalParameter
value: 5600000.0
name: kon3

422108
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000020
type: Species
has part: PIRSF000582
initial amount: NaN
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000003
has part: Q9UD71
constant: false
boundary condition: false
name: D_PKA

422096
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

422084
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

metaid_0000088
type: Reaction
kinetic law: 424704
product: 424692
product: 424680
reactant: 424668
fast: false
reversible: false
name: D34:75_PP2B_unbinding

424716
type: LocalParameter
value: 1600.0
name: koff17

424692
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424680
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

424668
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000121
type: Reaction
kinetic law: 426223
product: 426211
product: 426199
reactant: 426187
fast: false
reversible: false
name: D34:75:137_PP2AP_unbinding

426235
type: LocalParameter
value: 40.0
name: koff26

426211
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

426199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

426187
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000084
type: Reaction
kinetic law: 424524
product: 424512
product: 424500
reactant: 424488
is version of: http://identifiers.org/ec-code/2.7.11.11
fast: false
reversible: false
name: D75:137_phospho_by_PKA_on_34

424536
type: LocalParameter
value: 0.0
name: kcat21

424512
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

424500
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

424488
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

metaid_0000254
type: Event
event assignment: 429233
trigger: 429221
use values from trigger time: true
name: ca_off4

429221
type: Trigger
persistant: true
initial value: true

metaid_0000011
type: Reaction
kinetic law: 421940
product: 421928
reactant: 421916
reactant: 421904
is version of: GO:0019901
fast: false
reversible: false
name: DCDK1_binding

421952
type: LocalParameter
value: 4400000.0
name: kon2

421928
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

421916
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

421904
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000188
type: Reaction
kinetic law: 428824
product: 428812
reactant: 428800
is version of: GO:0006816
fast: false
reversible: false
name: Ca_in

428812
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

428800
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

metaid_0000022
type: Reaction
kinetic law: 422180
product: 422168
product: 422156
reactant: 422144
fast: false
reversible: false
name: D_PKA_unbinding

422192
type: LocalParameter
value: 10.8
name: koff3

422168
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

422156
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

422144
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000097
type: Reaction
fast: false
reactant: 425088
kinetic law: 425124
is version of: GO:0033192
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 425112
name: D34:75:137_dephospho_by_PP2B_on_34
reversible: false
product: 425100

425088
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

425136
type: LocalParameter
value: 0.03
name: kcat27

425112
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

425100
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000260
type: Event
event assignment: 429377
trigger: 429365
use values from trigger time: true
name: ca_off10

429365
type: Trigger
persistant: true
initial value: true

metaid_0000170
type: Reaction
kinetic law: 428051
product: 428038
product: 428026
reactant: 428014
fast: false
reversible: false
name: cAMP2_R2C2_unbinding

428063
type: LocalParameter
value: 33.0
name: koff38

428038
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

428026
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

428014
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000164

metaid_0000157
type: Reaction
kinetic law: 427630
product: 427617
product: 427605
reactant: 427593
fast: false
reversible: false
name: PP2BinactiveCa2_Ca_unbinding

427641
type: LocalParameter
value: 1.0
name: koff35

427617
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000154

427605
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

427593
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000136
type: Reaction
kinetic law: 426824
product: 426812
reactant: 426800
reactant: 426788
is version of: GO:0030346
fast: false
reversible: false
name: CK1P_PP2B_binding

426836
type: LocalParameter
value: 3.0E7
name: kon29

426812
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

426800
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

426788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000064
type: Reaction
kinetic law: 423683
product: 423671
reactant: 423659
reactant: 423647
is version of: GO:0019903
fast: false
reversible: false
name: D137_PP2C_binding

423695
type: LocalParameter
value: 7500000.0
name: kon13

423671
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

423659
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

423647
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000240
type: Event
event assignment: 428896
trigger: 428884
use values from trigger time: true
name: cAMP_pulse

428884
type: Trigger
persistant: true
initial value: true

metaid_0000081
type: Reaction
product: 424391
is version of: GO:0004693
fast: false
kinetic law: 424403
product: 424379
reversible: false
reactant: 424367
is version of: http://identifiers.org/ec-code/2.7.11.22
name: D34:137_phospho_by_CDK5_on_75

424391
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

424415
type: LocalParameter
value: 3.0
name: kcat18

424379
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

424367
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000060
type: Reaction
kinetic law: 423563
product: 423551
reactant: 423539
reactant: 423527
is version of: GO:0019901
fast: false
reversible: false
name: D137_CDK5_binding

423575
type: LocalParameter
value: 5600000.0
name: kon11

423551
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

423539
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

423527
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000189
type: Reaction
kinetic law: 428860
product: 428848
reactant: 428836
fast: false
reversible: false
name: Ca_destroy

428872
type: LocalParameter
value: 1.7
name: k58

428848
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000190

428836
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

metaid_0000058
type: Reaction
name: D75_dephospho_by_PP2AP
product: 423419
product: 423431
fast: false
reactant: 423407
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0004722
kinetic law: 423443
reversible: false

423419
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

423431
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

423407
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

423455
type: LocalParameter
value: 24.0
name: kcat10

metaid_0000151
type: Reaction
reactant: 427365
product: 427389
is version of: GO:0004691
fast: false
reversible: false
product: 427377
kinetic law: 427401
is version of: http://identifiers.org/ec-code/2.7.11.11
name: PP2A_phospho_by_PKA

427365
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

427389
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

427377
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

427413
type: LocalParameter
value: 4.0
name: kcat33

metaid_0000158
type: Reaction
kinetic law: 427690
product: 427678
product: 427666
reactant: 427654
fast: false
reversible: false
name: PP2B_inactivation

427702
type: LocalParameter
value: 1.0
name: koff36

427678
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000154

427666
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

427654
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

W3 CDTF: Thu Jul 05 17:51:03 BST 2012

metaid_0000079
type: Reaction
kinetic law: 424343
product: 424331
product: 424319
reactant: 424307
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D34:75_phospho_by_CK1_on_137

424355
type: LocalParameter
value: 3.0
name: kcat14

424331
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

424319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

424307
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000099
type: Reaction
kinetic law: 425184
product: 425172
reactant: 425160
reactant: 425148
is version of: GO:0051721
fast: false
reversible: false
name: D34:75_PP2A_binding

425196
type: LocalParameter
value: 3800000.0
name: kon15

425172
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

425160
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

425148
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000112
type: Reaction
product: 425778
is version of: GO:0004722
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
name: D34:75_dephospho_by_PP2AP_on_75
fast: false
reactant: 425766
product: 425790
kinetic law: 425802

425778
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

425766
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

425790
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

425814
type: LocalParameter
value: 24.0
name: kcat16

metaid_0000263
type: Parameter
constant: true
value: 6.6E-6
name: kon_high

metaid_0000090
type: Reaction
kinetic law: 424824
product: 424812
reactant: 424800
reactant: 424788
is version of: GO:0030346
fast: false
reversible: false
name: D34:137_PP2B_binding

424836
type: LocalParameter
value: 75000.0
name: kon19

424812
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000091
type: Species
has part: PIRSF000911
constant: false
initial amount: NaN
in compartment: metaid_0000003
initial concentration: 0.0
has only substance units: false
boundary condition: false
has part: Q9UD71
name: D34:137_PP2B

424800
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000172
type: Reaction
kinetic law: 428171
product: 428159
product: 428147
reactant: 428135
fast: false
reversible: false
name: cAMP4_R2C2_unbinding

428183
type: LocalParameter
value: 32.5
name: koff40

428159
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

428147
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

428135
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

metaid_0000249
type: Event
event assignment: 429137
trigger: 429125
use values from trigger time: true
name: ca_on9

429125
type: Trigger
persistant: true
initial value: true

metaid_0000082
type: Reaction
kinetic law: 424464
product: 424452
reactant: 424439
reactant: 424427
is version of: GO:0034236
fast: false
reversible: false
name: D75:137_PKA_binding

424476
type: LocalParameter
value: 5600000.0
name: kon21

424452
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

424439
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

424427
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000095
type: Reaction
kinetic law: 425004
product: 424992
reactant: 424980
reactant: 424968
is version of: GO:0030346
fast: false
reversible: false
name: D34:75:137_PP2B_binding

425016
type: LocalParameter
value: 75000.0
name: kon27

424992
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

424980
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424968
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000048
type: Reaction
kinetic law: 423021
product: 423009
reactant: 422997
reactant: 422985
is version of: GO:0051721
fast: false
reversible: false
name: D75_PP2AP_binding

423034
type: LocalParameter
value: 1.7E7
name: kon10

423009
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

422997
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

422985
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000265
type: Parameter
constant: true
value: 2.0
name: spike_interval

metaid_0000186
type: Reaction
kinetic law: 428716
product: 428704
product: 428692
reactant: 428680
fast: false
reversible: false
name: cAMP_PDEP_unbinding

428728
type: LocalParameter
value: 80.0
name: koff45

428704
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

428692
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

428680
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000185

metaid_0000185
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 0.0
name: cAMP_PDEP
has only substance units: false
has part: CHEBI:17489
has part: IPR000396
constant: false
in compartment: metaid_0000003

metaid_0000182
type: Reaction
product: 428572
is version of: GO:0004112
fast: false
is version of: GO:0006198
name: cAMP_PDE_degradation
product: 428584
reactant: 428560
reversible: false
kinetic law: 428596

428572
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000183

428584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

428560
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000180

428608
type: LocalParameter
value: 10.0
name: kcat44

metaid_0000134
type: Reaction
product: 426691
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
reactant: 426667
name: D34:75:137_dephospho_by_PP2C_on_137
kinetic law: 426703
fast: false
product: 426679
is version of: GO:0004722

426691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426667
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

426715
type: LocalParameter
value: 3.0
name: kcat28

426679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000148
type: Reaction
kinetic law: 427281
product: 427269
reactant: 427257
reactant: 427245
is version of: GO:0034236
fast: false
reversible: false
name: PP2A_PKA_binding

427293
type: LocalParameter
value: 1.0E7
name: kon33

427269
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

427257
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

427245
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000264
type: Parameter
constant: true
value: 2.0
name: spike_duration

metaid_0000257
type: Event
event assignment: 429305
trigger: 429293
use values from trigger time: true
name: ca_off7

429293
type: Trigger
persistant: true
initial value: true

metaid_0000055
type: Reaction
kinetic law: 423263
product: 423251
product: 423239
reactant: 423227
fast: false
reversible: false
name: D75_PKA_unbinding

423275
type: LocalParameter
value: 10.8
name: koff8

423251
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

423239
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

423227
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000252
type: Event
event assignment: 429185
trigger: 429173
use values from trigger time: true
name: ca_off2

429173
type: Trigger
persistant: true
initial value: true

metaid_0000266
type: Parameter
constant: true
value: 2.5E-8
name: kon_low

metaid_0000072
type: Reaction
kinetic law: 424043
product: 424031
product: 424019
reactant: 424007
fast: false
reversible: false
name: D137_PP2C_unbinding

424055
type: LocalParameter
value: 12.0
name: koff13

424031
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

424019
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

424007
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000092
type: Reaction
fast: false
is version of: GO:0033192
reactant: 424848
product: 424872
product: 424860
reversible: false
name: D34:137_dephospho_by_PP2B_on_34
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 424884

424848
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

424872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424860
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

424896
type: LocalParameter
value: 0.03
name: kcat19

metaid_0000024
type: Reaction
product: 422228
name: D_Phospho_by_PKA_on_34
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.11
product: 422216
fast: false
reactant: 422204
kinetic law: 422240
is version of: GO:0004691

422228
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

422216
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

422204
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

422252
type: LocalParameter
value: 2.7
name: kcat3

metaid_0000187
type: Reaction
kinetic law: 428776
product: 428764
product: 428752
reactant: 428740
is version of: GO:0006198
fast: false
reversible: false
name: cAMP_PDEP_degradation

428788
type: LocalParameter
value: 20.0
name: kcat45

428764
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

428752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000183

428740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000185

metaid_0000261
type: Parameter
constant: true
value: 400.0
name: cAMP_delay

metaid_0000253
type: Event
event assignment: 429209
trigger: 429197
use values from trigger time: true
name: ca_off3

429197
type: Trigger
persistant: true
initial value: true

metaid_0000141
type: Reaction
kinetic law: 426992
product: 426980
reactant: 426968
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: CK1_phosphorylation

427004
type: LocalParameter
value: 1.0
name: kcat30

426980
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

426968
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000077
type: Reaction
kinetic law: 424223
product: 424211
product: 424199
reactant: 424187
fast: false
reversible: false
name: D34:137_CDK5_unbinding

424235
type: LocalParameter
value: 12.0
name: koff18

424211
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

424199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

424187
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000110
type: Reaction
kinetic law: 425742
product: 425729
reactant: 425716
reactant: 425703
is version of: GO:0051721
fast: false
reversible: false
name: D34:75_PP2AP_binding

425754
type: LocalParameter
value: 1.7E7
name: kon16

425729
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

425716
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

425703
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000124
type: Reaction
product: 426331
name: D34:137_dephospho_by_PP2C_on_137
reversible: false
is version of: GO:0004722
product: 426319
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 426307
kinetic law: 426343

426331
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

426319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

426307
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

426355
type: LocalParameter
value: 3.0
name: kcat20

metaid_0000184
type: Reaction
reversible: false
is version of: GO:0030552
fast: false
reactant: 428620
product: 428644
kinetic law: 428656
name: cAMP_PDEP_binding
reactant: 428632
is version of: GO:0004112

428620
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

428644
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000185

428668
type: LocalParameter
value: 5040000.0
name: kon45

428632
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

metaid_0000116
type: Reaction
kinetic law: 425983
fast: false
product: 425971
reversible: false
reactant: 425947
name: D75:137_dephospho_by_PP2AP_on_75
product: 425959
is version of: GO:0004722
is version of: http://identifiers.org/ec-code/3.1.3.16

425995
type: LocalParameter
value: 24.0
name: kcat23

425971
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

425947
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

425959
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000073
type: Reaction
kinetic law: 424103
product: 424091
reactant: 424079
reactant: 424067
is version of: GO:0019901
fast: false
reversible: false
name: D34:75_CK1_binding

424115
type: LocalParameter
value: 4400000.0
name: kon14

424091
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

424079
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

424067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000031
type: Reaction
kinetic law: 422420
product: 422408
reactant: 422396
reactant: 422384
is version of: GO:0030346
fast: false
reversible: false
name: D34_PP2B_binding

422432
type: LocalParameter
value: 1.0E7
name: kon6

422408
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

422396
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

422384
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000093
type: Reaction
kinetic law: 424944
product: 424932
product: 424920
reactant: 424908
fast: false
reversible: false
name: D34:137_PP2B_unbinding

424956
type: LocalParameter
value: 0.12
name: koff19

424932
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

424920
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

424908
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000248
type: Event
event assignment: 429113
trigger: 429101
use values from trigger time: true
name: ca_on8

429101
type: Trigger
persistant: true
initial value: true

metaid_0000163
type: Reaction
reactant: 427786
product: 427798
reactant: 427774
kinetic law: 427810
reversible: false
is version of: GO:0034237
fast: false
name: cAMP_R2C2_binding_by_cAMP
is version of: GO:0030552

427786
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

427798
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000164

427774
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

427822
type: LocalParameter
value: 5.4E7
name: kon38