BIOMD0000000151
type: SBMLModel
species: metaid_0000151
reaction: metaid_0000241
reaction: metaid_0000195
species: metaid_0000142
species: metaid_0000115
parameter: metaid_0000021
parameter: metaid_0000062
reaction: metaid_0000213
reaction: metaid_0000233
parameter: metaid_0000055
species: metaid_0000163
parameter: metaid_0000026
species: metaid_0000127
parameter: metaid_0000019
species: metaid_0000112
parameter: metaid_0000050
reaction: metaid_0000201
reaction: metaid_0000221
parameter: metaid_0000043
reaction: metaid_0000209
parameter: metaid_0000084
species: metaid_0000160
parameter: metaid_0000014
parameter: metaid_0000077
parameter: metaid_0000042
parameter: metaid_0000007
name: Singh2006_IL6_Signal_Transduction
parameter: metaid_0000048
species: metaid_0000124
parameter: metaid_0000006
reaction: metaid_0000194
reaction: metaid_0000243
parameter: metaid_0000065
species: metaid_0000144
reaction: metaid_0000185
reaction: metaid_0000224
parameter: metaid_0000099
species: metaid_0000120
reaction: metaid_0000215
parameter: metaid_0000031
parameter: metaid_0000029
parameter: metaid_0000057
occurs in: BTO:0000759
substance units: metaid_0000251
parameter: metaid_0000100
reaction: metaid_0000182
parameter: metaid_0000094
reaction: metaid_0000212
parameter: metaid_0000087
reaction: metaid_0000238
reaction: metaid_0000203
parameter: metaid_0000045
occurs in: BTO:0000575
parameter: metaid_0000060
species: metaid_0000158
parameter: metaid_0000086
parameter: metaid_0000009
parameter: metaid_0000024
parameter: metaid_0000103
is described by: http://identifiers.org/pubmed/16752369
reaction: metaid_0000188
volume units: metaid_0000084
reaction: metaid_0000242
species: metaid_0000154
reaction: metaid_0000218
species: metaid_0000118
parameter: metaid_0000022
parameter: metaid_0000012
parameter: metaid_0000075
species: metaid_0000122
length unit: length
species: metaid_0000175
reaction: metaid_0000230
parameter: metaid_0000039
parameter: metaid_0000090
curated: true
species: metaid_0000138
reaction: metaid_0000192
parameter: metaid_0000070

metaid_0000151
type: Species
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 41667.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK

metaid_0000108
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol

metaid_0000241
type: Reaction
kinetic law: 051280
product: 051267
reactant: 051255
reactant: 051243
is version of: GO:0005515
fast: false
reversible: true
name: MEK-PP-Phosp2 complex formation

051267
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000168

metaid_0000168
type: Species
has part: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-PP-Phosp2

051255
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

metaid_0000156
type: Species
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-PP

051243
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp2

metaid_0000195
type: Reaction
kinetic law: 049200
product: 049188
reactant: 049176
reactant: 049164
is version of: GO:0046983
fast: false
reversible: true
name: STAT3C dimerization

049188
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000131

metaid_0000131
type: Species
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3C-STAT3Cast

049176
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000117
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1000.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3C

049164
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000119
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3Cast

metaid_0000142
type: Species
is version of: Q60631
constant: false
boundary condition: false
has only substance units: false
initial concentration: 85.0
initial amount: NaN
in compartment: metaid_0000108
name: Grb2

metaid_0000115
type: Species
has only substance units: false
has part: P22272
boundary condition: false
constant: false
has part: P35235
has part: Q6PDI9
has part: P08505
initial concentration: 0.0
name: (IL6-gp80-gp130-JAK)ast2-JAK
has part: P52332
in compartment: metaid_0000108
initial amount: NaN

metaid_0000021
type: Parameter
constant: true
value: 0.02

metaid_0000062
type: Parameter
constant: true
value: 0.0214

metaid_0000213
type: Reaction
kinetic law: 050005
modifier: 049993
product: 049981
is: GO:0006351
fast: false
reversible: false
name: SOCS3N transcription

metaid_0000135
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3Nast-STAT3Nast

metaid_0000250
type: Compartment
is: GO:0005634
constant: true
size: 1.0
spatial dimensions: 3.0
name: nucleus

049981
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000141

metaid_0000141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: Mrna-SOCS3N

metaid_0000233
type: Reaction
kinetic law: 050895
product: 050883
reactant: 050871
reactant: 050859
is version of: GO:0005515
fast: false
reversible: true
name: Raf-Phosp1 complex formation

050883
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000148

metaid_0000148
type: Species
has part: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Rafast-Phosp1

050871
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

metaid_0000150
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp1

050859
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

metaid_0000149
type: Species
is version of: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Rafast

metaid_0000055
type: Parameter
constant: true
value: 0.01

metaid_0000163
type: Species
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2-STAT3Nast

metaid_0000026
type: Parameter
constant: true
value: 9.0E-4

metaid_0000127
type: Species
has part: P22272
has only substance units: false
has part: P35235
has part: Q6PDI9
initial concentration: 0.0
constant: false
boundary condition: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2-Grb2
has part: P08505
has part: Q60631
in compartment: metaid_0000108
has part: P52332
initial amount: NaN

metaid_0000019
type: Parameter
constant: true
value: 0.001

metaid_0000112
type: Species
has part: Q6PDI9
has part: P52332
constant: false
boundary condition: false
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000108
name: gp130-JAK
initial amount: NaN

metaid_0000050
type: Parameter
constant: true
value: 400.0

metaid_0000201
type: Reaction
kinetic law: 049488
product: 049476
reactant: 049464
reactant: 049452
is version of: GO:0005515
fast: false
reversible: true
name: PP1-STAT3C dimer complex formation

049476
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000174

metaid_0000174
type: Species
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1-STAT3Cast-STAT3Cast

049464
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

metaid_0000134
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: STAT3Cast-STAT3Cast

049452
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1

metaid_0000221
type: Reaction
kinetic law: 050317
product: 050305
reactant: 050293
reactant: 050281
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation

050305
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000125
type: Species
has part: P52332
initial concentration: 0.0
has part: Q60631
boundary condition: false
has part: P35235
constant: false
has part: P08505
has part: P22272
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2
has only substance units: false
in compartment: metaid_0000108
has part: Q6PDI9
initial amount: NaN

050293
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

050281
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

metaid_0000123
type: Species
has part: P08505
initial amount: NaN
has part: P22272
constant: false
has only substance units: false
has part: Q6PDI9
in compartment: metaid_0000108
has part: P52332
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast
initial concentration: 0.0
boundary condition: false
has part: P35235

metaid_0000043
type: Parameter
constant: true
value: 0.005

metaid_0000209
type: Reaction
kinetic law: 049825
product: 049813
reactant: 049801
reactant: 049789
is version of: GO:0005515
fast: false
reversible: true
name: PP2-STAT3N complex formation

049813
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000163

049801
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

metaid_0000136
type: Species
is version of: P42227
constant: false
boundary condition: false
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initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3Nast

049789
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 60.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2

metaid_0000084
type: Parameter
constant: true
value: 0.011

metaid_0000160
type: Species
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-PP

metaid_0000014
type: Parameter
constant: true
value: 0.008

metaid_0000077
type: Parameter
constant: true
value: 0.0079

metaid_0000042
type: Parameter
constant: true
value: 0.5

metaid_0000007
type: Parameter
constant: true
value: 0.05

metaid_0000048
type: Parameter
constant: true
value: 0.005

metaid_0000124
type: Species
is version of: P35235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: SHP2ast

metaid_0000006
type: Parameter
constant: true
value: 0.1

metaid_0000194
type: Reaction
kinetic law: 049152
product: 049140
product: 049128
reactant: 049116
is version of: GO:0032516
fast: false
reversible: false
name: PP1-STAT3Cast dissociation

049140
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

049128
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

049116
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000129

metaid_0000129
type: Species
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: PP1-STAT3Cast

metaid_0000243
type: Reaction
is: GO:0004708
product: 051364
reactant: 051340
is: http://identifiers.org/ec-code/2.7.12.2
reversible: false
fast: false
name: ERK-MEK-PP complex dissociation
product: 051352
kinetic law: 051376

051364
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

051340
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

metaid_0000158
type: Species
in compartment: metaid_0000108
constant: false
initial amount: NaN
has part: Q3TMJ8
name: ERK-MEK-PP
boundary condition: false
initial concentration: 0.0
has only substance units: false
has part: P63085

051352
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000159

metaid_0000159
type: Species
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-P

metaid_0000065
type: Parameter
constant: true
value: 0.015

metaid_0000144
type: Species
has part: Q62245
initial concentration: 0.0
has part: P35235
has part: P08505
has part: P22272
has part: Q6PDI9
initial amount: NaN
has part: Q60631
in compartment: metaid_0000108
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP
boundary condition: false
has part: Q61411
constant: false
has part: P52332

metaid_0000185
type: Reaction
fast: false
product: 048707
is version of: GO:0043624
name: IL6-gp80-gp130-JAK dimer-SHP2 dissociation
reactant: 048683
is: http://identifiers.org/ec-code/3.1.3.48
reversible: false
kinetic law: 048719
product: 048695

048707
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

metaid_0000113
type: Species
boundary condition: false
initial concentration: 0.0
constant: false
has part: P08505
has part: P22272
name: (IL6-gp80-gp130-JAK)2
has only substance units: false
initial amount: NaN
in compartment: metaid_0000108
has part: Q6PDI9
has part: P52332

048683
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

048695
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

metaid_0000116
type: Species
is version of: P35235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000108
name: SHP2

metaid_0000224
type: Reaction
kinetic law: 050461
product: 050449
reactant: 050437
reactant: 050425
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation

050449
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

050437
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

metaid_0000143
type: Species
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 19000.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GDP

050425
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000099
type: Parameter
constant: true
value: 0.033

metaid_0000120
type: Species
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3Cast
in compartment: metaid_0000108
initial concentration: 0.0
constant: false
initial amount: NaN
has part: P42227
has part: Q6PDI9
has part: P08505
has part: P22272
has part: P52332
boundary condition: false

metaid_0000215
type: Reaction
kinetic law: 050065
reactant: 050053
is version of: GO:0006402
fast: false
reversible: false
name: SOCS3 mRNA degradation

050053
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

metaid_0000170
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: Mrna-SOCS3C

metaid_0000031
type: Parameter
constant: true
value: 0.2

metaid_0000029
type: Parameter
constant: true
value: 0.003

metaid_0000057
type: Parameter
constant: true
value: 0.0015

metaid_0000251
type: SBMLUnitsDef
unit: 048388
name: nano mole

048388
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000100
type: Parameter
constant: true
value: 1.1E-4

metaid_0000182
type: Reaction
kinetic law: 048597
product: 048585
reactant: 048571
is version of: GO:0042803
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimerization

048585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

048571
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000111

metaid_0000111
type: Species
has part: P08505
initial amount: NaN
has part: P22272
constant: false
has only substance units: false
has part: Q6PDI9
has part: P52332
boundary condition: false
in compartment: metaid_0000108
name: IL6-gp80-gp130-JAK
initial concentration: 0.0

metaid_0000094
type: Parameter
constant: true
value: 0.0143

metaid_0000212
type: Reaction
product: 049945
reactant: 049933
kinetic law: 049969
product: 049957
is version of: GO:0043624
reversible: false
fast: false
name: PP2-STAT3N dimer dissociation
is version of: GO:0032516

049945
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000139

metaid_0000139
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3N-STAT3Nast

049933
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

metaid_0000138
type: Species
has part: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: PP2-STAT3Nast-STAT3Nast

049957
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000087
type: Parameter
constant: true
value: 0.011

metaid_0000238
type: Reaction
kinetic law: 051135
product: 051123
product: 051111
reactant: 051099
is version of: GO:0032516
fast: false
reversible: false
name: MEK-PP-Phosp2 dissociation

051123
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000153

metaid_0000153
type: Species
is version of: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P

051111
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

051099
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000168

metaid_0000203
type: Reaction
kinetic law: 049572
product: 049560
product: 049548
reactant: 049536
is version of: GO:0032516
fast: false
reversible: false
name: PP1-STAT3C dimer dissociation

049560
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000131

049548
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

049536
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000174

metaid_0000045
type: Parameter
constant: true
value: 0.2

metaid_0000060
type: Parameter
constant: true
value: 0.55

metaid_0000086
type: Parameter
constant: true
value: 3.5

metaid_0000009
type: Parameter
constant: true
value: 0.02

metaid_0000024
type: Parameter
constant: true
value: 9.0E-4

metaid_0000103
type: Parameter
constant: true
value: 0.27

metaid_0000188
type: Reaction
kinetic law: 048864
product: 048852
reactant: 048840
reactant: 048828
is version of: GO:0043623
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-STAT3Cast complex formation

048852
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

048840
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000114
type: Species
has part: Q6PDI9
has part: P52332
boundary condition: false
has part: P22272
initial concentration: 0.0
name: (IL6-gp80-gp130-JAK)_ast2
has part: P08505
has only substance units: false
initial amount: NaN
in compartment: metaid_0000108
constant: false

048828
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000242
type: Reaction
kinetic law: 051328
product: 051316
reactant: 051304
reactant: 051292
is version of: GO:0005515
fast: false
reversible: true
name: ERK-MEK-PP complex formation

051316
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000158

051304
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

051292
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000157

metaid_0000157
type: Species
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 35000.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK

metaid_0000154
type: Species
has part: Q3TMJ8
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P-Phosp2

metaid_0000218
type: Reaction
kinetic law: 050173
product: 050161
product: 050149
reactant: 050137
is version of: GO:0043624
fast: false
reversible: false
name: Complex dissociation

050161
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000121
type: Species
is version of: O35718
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: SOCS3

050149
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000172

metaid_0000172
type: Species
has part: P22272
has part: P42227
in compartment: metaid_0000108
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 0.0
has part: P08505
has part: P35235
has part: Q6PDI9
has part: P52332
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2

050137
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

metaid_0000133
type: Species
has part: P42227
has part: P52332
initial amount: NaN
has only substance units: false
has part: P22272
in compartment: metaid_0000108
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2
constant: false
has part: P08505
initial concentration: 0.0
has part: O35718
has part: P35235
has part: Q6PDI9
boundary condition: false

metaid_0000118
type: Species
has only substance units: false
has part: P22272
in compartment: metaid_0000108
boundary condition: false
name: (IL6-gp80-gp130-JAK)ast2-STAT3C
constant: false
has part: P42227
has part: P52332
initial amount: NaN
has part: Q6PDI9
has part: P08505
initial concentration: 0.0

metaid_0000022
type: Parameter
constant: true
value: 0.1

metaid_0000012
type: Parameter
constant: true
value: 0.005

metaid_0000075
type: Parameter
constant: true
value: 0.3

metaid_0000122
type: Species
name: (IL6-gp80-gp130-JAK)ast2-SOCS3
has part: Q6PDI9
initial amount: NaN
has part: P22272
has part: O35718
has part: P52332
initial concentration: 0.0
boundary condition: false
constant: false
has part: P08505
has only substance units: false
in compartment: metaid_0000108

metaid_0000175
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: Grb2-SOS
in compartment: metaid_0000108
has part: Q60631
initial concentration: 0.0
has part: Q62245
has only substance units: false

metaid_0000230
type: Reaction
kinetic law: 050751
product: 050739
reactant: 050727
reactant: 050715
is version of: GO:0043623
fast: false
reversible: true
name: Complex formation

050739
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

metaid_0000166
type: Species
has only substance units: false
name: (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP
has part: Q61411
boundary condition: false
has part: P35235
has part: Q60631
has part: P22272
in compartment: metaid_0000108
constant: false
initial amount: NaN
initial concentration: 0.0
has part: P52332
has part: P08505
has part: Q62245
has part: Q6PDI9

050727
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

050715
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

metaid_0000171
type: Species
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GTPast

metaid_0000039
type: Parameter
constant: true
value: 340.0

metaid_0000090
type: Parameter
constant: true
value: 0.058

metaid_0000192
type: Reaction
kinetic law: 049056
product: 049044
product: 049032
reactant: 049020
is version of: GO:0043624
fast: false
reversible: true
name: IL6-gp80-gp130-JAK SHP2 Grb2 dissociation

049044
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

049032
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

metaid_0000126
type: Species
name: SHP2ast-Grb2
has part: P35235
initial concentration: 0.0
boundary condition: false
initial amount: NaN
has part: Q60631
has only substance units: false
constant: false
in compartment: metaid_0000108

049020
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000070
type: Parameter
constant: true
value: 1.0E-4

metaid_0000010
type: Parameter
constant: true
value: 0.04

metaid_0000063
type: Parameter
constant: true
value: 0.03

metaid_0000089
type: Parameter
constant: true
value: 0.058

metaid_0000202
type: Reaction
kinetic law: 049524
product: 049512
reactant: 049500
is version of: GO:0000060
fast: false
reversible: false
name: STAT3C dimer phosphorylation

049512
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000135

049500
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000134

metaid_0000222
type: Reaction
kinetic law: 050365
product: 050353
reactant: 050341
reactant: 050329
is version of: GO:0005515
fast: false
reversible: true
name: Complex formation

050353
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

050341
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

metaid_0000162
type: Species
is version of: Q62245
constant: false
boundary condition: false
has only substance units: false
initial concentration: 34.0
initial amount: NaN
in compartment: metaid_0000108
name: SOS

050329
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000125

metaid_0000044
type: Parameter
constant: true
value: 0.001

metaid_0000027
type: Parameter
constant: true
value: 0.1

metaid_0000106
type: Parameter
constant: true
value: 0.014

metaid_0000008
type: Parameter
constant: true
value: 0.02

metaid_0000180
type: Reaction
kinetic law: 048506
product: 048493
product: 048481
reactant: 048467
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dissociation

048493
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

metaid_0000110
type: Species
initial concentration: 0.0
has part: P08505
name: IL6-gp80
boundary condition: false
has part: P22272
has only substance units: false
in compartment: metaid_0000108
constant: false
initial amount: NaN

048481
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000112

048467
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

metaid_0000245
type: Reaction
name: ERK-PP formation
product: 051460
is: GO:0004708
is: http://identifiers.org/ec-code/2.7.12.2
kinetic law: 051472
reversible: false
product: 051448
reactant: 051436
fast: false

051460
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

051448
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

051436
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000173
type: Species
boundary condition: false
in compartment: metaid_0000108
name: ERK-P-MEK-PP
has part: P63085
constant: false
initial amount: NaN
has part: Q3TMJ8
initial concentration: 0.0
has only substance units: false

metaid_0000092
type: Parameter
constant: true
value: 0.5

metaid_0000179
type: Reaction
kinetic law: 048454
reactant: 048441
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80 complex dissociation

048441
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

metaid_0000210
type: Reaction
kinetic law: 049873
product: 049861
product: 049849
reactant: 049837
is version of: GO:0043624
fast: false
reversible: true
name: STAT3N dimer dissociation

049861
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000136

049849
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000132
type: Species
is version of: P42227
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000250
name: STAT3N

049837
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000139

metaid_0000244
type: Reaction
kinetic law: 051424
product: 051412
product: 051400
reactant: 051388
is version of: GO:0043624
fast: false
reversible: true
name: ERK-P-MEK-PP complex dissociation

051412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

051400
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000159

051388
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000173

metaid_0000066
type: Parameter
constant: true
value: 1.3

metaid_0000217
type: Reaction
kinetic law: 050125
reactant: 050113
is version of: GO:0030163
fast: false
reversible: false
name: SOCS3 degradation

050113
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000011
type: Parameter
constant: true
value: 0.2

metaid_0000147
type: Species
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Raf-Ras-GTP

metaid_0000183
type: Reaction
kinetic law: 048635
product: 048623
reactant: 048610
is version of: GO:0043624
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimer dissociation

048623
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000111

048610
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

metaid_0000101
type: Parameter
constant: true
value: 6.7

metaid_0000177
type: Species
has part: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-PP-Phosp3

metaid_0000232
type: Reaction
kinetic law: 050847
product: 050835
product: 050823
reactant: 050811
is version of: GO:0005515
fast: false
reversible: true
name: Raf-Ras-GTP dissociation

050835
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000171

050823
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

050811
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000147

metaid_0000054
type: Parameter
constant: true
value: 5.0E-4

metaid_0000205
type: Reaction
kinetic law: 049657
product: 049645
reactant: 049633
is version of: GO:0016311
fast: false
reversible: false
name: SHP2 dephosphorylation

049645
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

049633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

metaid_0000152
type: Species
boundary condition: false
initial concentration: 0.0
has part: Q3TMJ8
in compartment: metaid_0000108
initial amount: NaN
has part: Q99N57
has only substance units: false
name: MEK-Rafast
constant: false

metaid_0000088
type: Parameter
constant: true
value: 0.001833

metaid_0000239
type: Reaction
kinetic law: 051183
product: 051171
reactant: 051159
reactant: 051147
is version of: GO:0005515
fast: false
reversible: true
name: MEK-P-Phosp2 complex formation

051171
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

051159
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000153

051147
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

metaid_0000204
type: Reaction
kinetic law: 049621
product: 049609
reactant: 049597
reactant: 049584
is version of: GO:0005515
fast: false
reversible: false
name: Complex formation

049609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

049597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

049584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000164

metaid_0000164
type: Species
has part: P22272
has part: P52332
name: (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3
has part: Q6PDI9
has only substance units: false
constant: false
initial concentration: 0.0
has part: O35718
boundary condition: false
has part: P08505
initial amount: NaN
in compartment: metaid_0000108

metaid_0000018
type: Parameter
constant: true
value: 0.5

metaid_0000020
type: Parameter
constant: true
value: 0.2

metaid_0000046
type: Parameter
constant: true
value: 0.2

metaid_0000197
type: Reaction
kinetic law: 049284
product: 049272
reactant: 049260
reactant: 049248
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-SOCS2-STAT3C complex formation

049272
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000164

049260
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

049248
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000091
type: Parameter
constant: true
value: 2.5E-4

metaid_0000247
type: Reaction
reversible: false
product: 051544
reactant: 051532
fast: false
name: ERK-PP-Phosp3 dissociation
kinetic law: 051568
is version of: GO:0043624
product: 051556
is version of: GO:0032516

051544
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

metaid_0000176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 16667.0
initial amount: NaN
in compartment: metaid_0000108
name: Phosp3

051532
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000177

051556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000159

metaid_0000227
type: Reaction
kinetic law: 050606
product: 050594
reactant: 050582
reactant: 050570
is version of: GO:0005515
fast: false
reversible: true
name: Ras-GTP-Raf complex formation

050594
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000147

050582
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

metaid_0000145
type: Species
has part: Q61411
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: Ras-GTP

050570
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000146

metaid_0000146
type: Species
is version of: Q99N57
constant: false
boundary condition: false
has only substance units: false
initial concentration: 67.0
initial amount: NaN
in compartment: metaid_0000108
name: Raf

metaid_0000128
type: Species
boundary condition: false
constant: false
has part: P35235
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
has only substance units: false
has part: Q60631
name: SHP2ast-Grb2-SOS

metaid_0000069
type: Parameter
constant: true
value: 0.5

metaid_0000189
type: Reaction
kinetic law: 048912
product: 048900
reactant: 048888
reactant: 048876
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SHP2 complex formation

048900
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

048888
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048876
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

metaid_0000219
type: Reaction
kinetic law: 050221
product: 050209
reactant: 050197
reactant: 050185
is version of: GO:0005515
fast: false
reversible: true
name: SHP2-Grb2 complex formation

050209
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

050197
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

050185
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

metaid_0000013
type: Parameter
constant: true
value: 0.003

metaid_0000104
type: Parameter
constant: true
value: 0.005

metaid_0000161
type: Species
is version of: P63085
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000108
name: ERK-P-Phosp3

metaid_0000098
type: Parameter
constant: true
value: 16.0

metaid_0000072
type: Parameter
constant: true
value: 0.0053

metaid_0000231
type: Reaction
kinetic law: 050799
product: 050787
product: 050775
reactant: 050763
is version of: GO:0032516
fast: false
reversible: false
name: Raf-Phosp1 dissociation

050787
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000150

050775
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000146

050763
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000148

metaid_0000030
type: Parameter
constant: true
value: 2.0E-7

metaid_0000207
type: Reaction
kinetic law: 049729
product: 049717
reactant: 049705
is version of: GO:0043624
fast: false
reversible: true
name: STAT3N dimer dissociation

049717
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000136

049705
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000135

metaid_0000036
type: Parameter
constant: true
value: 0.2

metaid_0000064
type: Parameter
constant: true
value: 0.064

metaid_0000109
type: Species
is version of: P22272
constant: true
boundary condition: true
has only substance units: false
initial concentration: 8.0
initial amount: NaN
in compartment: metaid_0000108
name: gp80

metaid_0000028
type: Parameter
constant: true
value: 2.45E-4

metaid_0000107
type: Parameter
constant: true
value: 0.6

metaid_0000181
type: Reaction
kinetic law: 048558
modifier: 048546
product: 048532
reactant: 048519
is version of: GO:0005515
fast: false
reversible: false
name: gp130-JAK complex formation

metaid_0000167
type: Species
is version of: Q6PDI9
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.8
initial amount: NaN
in compartment: metaid_0000108
name: gp130

048532
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000112

048519
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000169

metaid_0000169
type: Species
is version of: P52332
constant: false
boundary condition: false
has only substance units: false
initial concentration: 12.0
initial amount: NaN
in compartment: metaid_0000108
name: JAK

metaid_0000199
type: Reaction
kinetic law: 049392
product: 049380
reactant: 049368
is version of: GO:0046983
fast: false
reversible: true
name: STAT3C dimerization

049380
type: SpeciesReference
stoichiometry: 0.5
species: metaid_0000134

049368
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000052
type: Parameter
constant: true
value: 5.0E-4

metaid_0000093
type: Parameter
constant: true
value: 2.9

metaid_0000246
type: Reaction
fast: false
kinetic law: 051520
reactant: 051484
is version of: GO:0043624
reversible: false
product: 051496
is version of: GO:0032516
name: ERK-P-Phosp3 complex dissociation
product: 051508

051484
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

051496
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

051508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000157

metaid_0000211
type: Reaction
fast: false
reactant: 049885
is version of: GO:0032516
product: 049897
name: PP2-STAT3N dissociation
is version of: GO:0043624
product: 049909
reversible: false
kinetic law: 049921

049885
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000163

049897
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

049909
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000237
type: Reaction
kinetic law: 051087
product: 051075
product: 051063
reactant: 051051
is version of: GO:0032516
fast: false
reversible: false
name: MEK-P-Phosp2 dissociation

051075
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000151

051063
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000155

051051
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000154

metaid_0000016
type: Parameter
constant: true
value: 0.4

metaid_0000079
type: Parameter
constant: true
value: 1.0

metaid_0000081
type: Parameter
constant: true
value: 7.0E-4

metaid_0000234
type: Reaction
kinetic law: 050943
product: 050931
reactant: 050919
reactant: 050907
is version of: GO:0005515
fast: false
reversible: true
name: MEK-Raf complex formation

050931
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

050919
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

050907
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000151

metaid_0000225
type: Reaction
kinetic law: 050509
product: 050497
product: 050485
reactant: 050473
is version of: GO:0043624
fast: false
reversible: true
name: Complex dissociation

050497
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000143

050485
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

050473
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000166

metaid_0000074
type: Parameter
constant: true
value: 0.0429

metaid_0000067
type: Parameter
constant: true
value: 0.023

metaid_0000206
type: Reaction
kinetic law: 049693
product: 049681
reactant: 049669
is: GO:0004713
is: http://identifiers.org/ec-code/2.7.10.2
fast: false
reversible: true
name: IL6-gp80-gp130-JAK-SHP2 phosphorylation

049681
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

049669
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000038
type: Parameter
constant: true
value: 1.7

metaid_0000191
type: Reaction
kinetic law: 049008
product: 048996
product: 048984
reactant: 048972
is version of: GO:0043624
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SHP2 dimer dissociation

048996
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048984
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

048972
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

metaid_0000096
type: Parameter
constant: true
value: 1.1E-4

metaid_0000198
type: Reaction
reactant: 049296
product: 049308
product: 049320
name: IL6-gp80-gp130-JAK-STAT3C-SOCS3-SHP2 dissociation
product: 049344
kinetic law: 049356
reversible: false
is: http://identifiers.org/ec-code/3.1.3.48
is: GO:0043624
fast: false
product: 049332

049296
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000133

049308
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

049320
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

049344
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

049332
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000051
type: Parameter
constant: true
value: 0.001

metaid_0000228
type: Reaction
kinetic law: 050654
product: 050642
reactant: 050630
reactant: 050618
is version of: GO:0043623
fast: false
reversible: true
name: Complex formation

050642
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

050630
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

050618
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

metaid_0000248
type: Reaction
kinetic law: 051616
product: 051604
reactant: 051592
reactant: 051580
is version of: GO:0005515
fast: false
reversible: true
name: ERK-P-Phosp3 formation

051604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000161

051592
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000159

051580
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

metaid_0000015
type: Parameter
constant: true
value: 0.8

metaid_0000186
type: Reaction
kinetic law: 048767
product: 048755
reactant: 048743
reactant: 048731
is version of: GO:0046983
fast: false
reversible: false
name: IL6-gp80-gp130-JAK -STAT3C complex formation

048755
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

048743
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048731
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000080
type: Parameter
constant: true
value: 1.0

metaid_0000105
type: Parameter
constant: true
value: 0.5

metaid_0000216
type: Reaction
kinetic law: 050101
modifier: 050089
product: 050077
is version of: GO:0006412
fast: false
reversible: false
name: SOCS3 translation

050077
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000032
type: Parameter
constant: true
value: 0.05

metaid_0000236
type: Reaction
kinetic law: 051039
product: 051027
reactant: 051015
reactant: 051003
is version of: GO:0005515
fast: false
reversible: true
name: MEK-P-Raf complex formation

051027
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

metaid_0000165
type: Species
has part: Q99N57
boundary condition: false
has only substance units: false
constant: false
has part: Q3TMJ8
initial amount: NaN
in compartment: metaid_0000108
name: MEK-P-Rafast
initial concentration: 0.0

051015
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

051003
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000153

metaid_0000058
type: Parameter
constant: true
value: 0.0045

metaid_0000073
type: Parameter
constant: true
value: 0.03

metaid_0000178
type: Reaction
kinetic law: 048428
modifier: 048415
product: 048402
is version of: GO:0005515
fast: false
reversible: false
name: IL6-gp80 complex formation

048402
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

metaid_0000003
type: Parameter
constant: true
value: 0.38

metaid_0000208
type: Reaction
kinetic law: 049777
product: 049765
reactant: 049753
reactant: 049741
is version of: GO:0005515
fast: false
reversible: true
name: PP2-STAT3N dimer complex formation

049765
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000138

049753
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000135

049741
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000137

metaid_0000037
type: Parameter
constant: true
value: 0.005

metaid_0000190
type: Reaction
kinetic law: 048960
product: 048948
reactant: 048936
reactant: 048924
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK -SOCS3 complex formation

048948
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

048936
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048924
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000061
type: Parameter
constant: true
value: 0.01

metaid_0000240
type: Reaction
name: MEK-P-Raf complex dissociation
is: http://identifiers.org/ec-code/2.7.11.1
product: 051207
product: 051219
reactant: 051195
reversible: false
fast: false
is: GO:0004672
kinetic law: 051231

051207
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

051219
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000156

051195
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000165

metaid_0000220
type: Reaction
kinetic law: 050269
product: 050257
product: 050245
reactant: 050233
is version of: GO:0043624
fast: false
reversible: true
name: Grb2-SOS dissociation

050257
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000142

050245
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

050233
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

metaid_0000095
type: Parameter
constant: true
value: 0.8

metaid_0000025
type: Parameter
constant: true
value: 0.3

metaid_0000053
type: Parameter
constant: true
value: 0.01

metaid_0000059
type: Parameter
constant: true
value: 0.01

metaid_0000017
type: Parameter
constant: true
value: 0.005

metaid_0000083
type: Parameter
constant: true
value: 0.2

metaid_0000076
type: Parameter
constant: true
value: 0.021

metaid_0000041
type: Parameter
constant: true
value: 0.06

metaid_0000235
type: Reaction
is: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
product: 050979
reactant: 050955
kinetic law: 050991
name: MEK-Raf complex dissociation
is: GO:0004672
product: 050967

050979
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000149

050955
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000152

050967
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000153

metaid_0000200
type: Reaction
kinetic law: 049440
product: 049428
reactant: 049416
reactant: 049404
is version of: GO:0005515
fast: false
reversible: true
name: IL6-gp80-gp130-JAK STAT3Cast complex formation

049428
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000129

049416
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

049404
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000130

metaid_0000196
type: Reaction
kinetic law: 049236
product: 049224
reactant: 049212
is version of: GO:0006611
fast: false
reversible: false
name: STAT3N transport

049224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

049212
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000132

metaid_0000082
type: Parameter
constant: true
value: 0.0717

metaid_0000047
type: Parameter
constant: true
value: 2.0E-7

metaid_0000034
type: Parameter
constant: true
value: 0.1

metaid_0000226
type: Reaction
kinetic law: 050558
product: 050546
product: 050534
reactant: 050522
is version of: GO:0032856
fast: false
reversible: true
name: Complex dissociation

050546
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000145

050534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

050522
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000144

metaid_0000005
type: Parameter
constant: true
value: 0.05

metaid_0000068
type: Parameter
constant: true
value: 2.2E-4

metaid_0000193
type: Reaction
is: GO:0043624
kinetic law: 049104
fast: false
name: IL6-gp80-gp130-JAK-SHP2-Grb2-SOS dissociation
is: http://identifiers.org/ec-code/2.7.10.2
product: 049080
product: 049092
is: GO:0004713
reversible: true
reactant: 049068

049080
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

049092
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

049068
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000127

metaid_0000184
type: Reaction
kinetic law: 048671
product: 048659
reactant: 048647
is: GO:0004713
is: http://identifiers.org/ec-code/2.7.10.2
fast: false
reversible: false
name: IL6-gp80-gp130-JAK dimer phosphorylation

048659
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048647
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

metaid_0000223
type: Reaction
kinetic law: 050413
product: 050401
reactant: 050389
reactant: 050377
is version of: GO:0005515
fast: false
reversible: true
name: SHP2Grb2-SOS complex formation

050401
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

050389
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000162

050377
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000126

metaid_0000249
type: Reaction
kinetic law: 051665
product: 051653
reactant: 051641
reactant: 051629
is version of: GO:0005515
fast: false
reversible: true
name: ERK-PP-Phosp3 formation

051653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000177

051641
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000160

051629
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000176

metaid_0000214
type: Reaction
kinetic law: 050041
product: 050029
reactant: 050017
is version of: GO:0006611
fast: false
reversible: false
name: SOCS3 mRNA translocation

050029
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000170

050017
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000141

metaid_0000056
type: Parameter
constant: true
value: 0.55

metaid_0000071
type: Parameter
constant: true
value: 0.001

metaid_0000097
type: Parameter
constant: true
value: 0.033

metaid_0000035
type: Parameter
constant: true
value: 0.001

W3 CDTF: Fri Aug 31 16:36:58 BST 2007

metaid_0000085
type: Parameter
constant: true
value: 0.001833

metaid_0000187
type: Reaction
reversible: false
product: 048792
is: http://identifiers.org/ec-code/2.7.10.2
product: 048804
reactant: 048780
kinetic law: 048816
name: IL6-gp80-gp130-JAK -STAT3C dissociation
is: GO:0043624
is: GO:0004713
fast: false

048792
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

048804
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

048780
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000040
type: Parameter
constant: true
value: 6.0

metaid_0000078
type: Parameter
constant: true
value: 0.4

metaid_0000229
type: Reaction
kinetic law: 050703
product: 050691
product: 050679
reactant: 050666
is version of: GO:0043623
fast: false
reversible: true
name: SHP2-Grb2-SOS dissociation

050691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000175

050679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000124

050666
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000128

metaid_0000023
type: Parameter
constant: true
value: 0.3

metaid_0000033
type: Parameter
constant: true
value: 0.02

metaid_0000049
type: Parameter
constant: true
value: 0.01

metaid_0000102
type: Parameter
constant: true
value: 0.3

metaid_0000004
type: Parameter
constant: true
value: 0.1

W3 CDTF: Thu Jul 05 17:44:32 BST 2012