BIOMD0000000150
type: SBMLModel
curated: true
compartment: 366833
is homolog to: REACT 152
rule: 366927
time units: metaid_0000127
species: 366847
modified:
  W3 CDTF: Wed Dec 01 22:10:11 GMT 2010
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nicolas
    family: Le Novère
is: MODEL4821491663
creator:
  ORG:
    orgname: DOQCS
  n:
    given: Sharat
    family: Vayttaden
parameter: 286077
is version of: GO:0000278
is described by: http://identifiers.org/pubmed/11959850
area units: metaid_0000005
parameter: 286065
is version of: ko04110
reaction: 366967
notes: Notes from the original DOCQS curator: In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. 277(26):23847-53 . Notes from BioModels DB curator: Although the parameters are those reported in the table I for CDK2/Cyclin A, the total fluorescence follows exactly the curve reported in the paper for CDK2/Cyclin H in figure 1B. Either the plot legend or the table is wrong.
substance units: metaid_0000126
volume units: metaid_0000084
created:
  W3 CDTF: Wed Sep 12 21:36:08 BST 2007
species: 366907
species: 366887
reaction: 366947
species: 366867
name: Morris2002_CellCycle_CDK2Cyclin
occurs in: http://identifiers.org/taxonomy/4932
length unit: length

366833
type: Compartment
constant: true
size: 1.0E-12
spatial dimensions: 3.0

366847
type: Species
has part: IPR015453
has part: P00546
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 366833

286077
type: Parameter
constant: false
value: 0.138886574074074

286065
type: Parameter
constant: false
value: 1.21210648148148

366967
type: Reaction
kinetic law: 286186
product: 286174
reactant: 286162
notes: Morris et al 2002 JBC 277(26): 23847--23853 kf and kb values not published kobs2 = 2.5 +- 0.1 /sec kf=0.813/sec and kb=0.557/sec used simulation
is version of: GO:0004693
fast: false
reversible: true

286186
type: KineticLaw
local parameters: 286210
local parameters: 286198
notes: kf*CDK2cycA-kb*CDK2cycA_star_

286210
type: LocalParameter
value: 0.557

286198
type: LocalParameter
value: 0.813

286174
type: SpeciesReference
stoichiometry: 1.0
species: 366907

366907
type: Species
has part: IPR015453
has part: P00546
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 366833

286162
type: SpeciesReference
stoichiometry: 1.0
species: 366847

366887
type: Species
is: P00546
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 366833

366947
type: Reaction
is version of: GO:0030332
reversible: true
is version of: GO:0006461
notes: kf = 19/sec/uM and kb = 25/sec Morris et al 2002 JBC 277(26): 23847--23853 Table pp.23849
fast: false
kinetic law: 286126
reactant: 286102
reactant: 286089
product: 286114

286126
type: KineticLaw
local parameters: 286150
local parameters: 286138
notes: kf*Cdk2*CyclinA-kb*CDK2cycA

286150
type: LocalParameter
value: 25.0

286138
type: LocalParameter
value: 1.9E7

286102
type: SpeciesReference
stoichiometry: 1.0
species: 366867

366867
type: Species
is version of: IPR015453
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0E-7
initial amount: NaN
in compartment: 366833

286089
type: SpeciesReference
stoichiometry: 1.0
species: 366887

286114
type: SpeciesReference
stoichiometry: 1.0
species: 366847