BIOMD0000000137
type: SBMLModel
parameter: metaid_0000016
parameter: metaid_0000007
species: metaid_0000050
curated: true
parameter: metaid_0000022
reaction: metaid_0000076
parameter: metaid_0000013
parameter: metaid_0000028
parameter: metaid_0000019
substance units: metaid_0000098
parameter: metaid_0000034
reaction: metaid_0000088
species: metaid_0000063
parameter: metaid_0000025
compartment: metaid_0000042
reaction: metaid_0000077
species: metaid_0000048
rule: metaid_0000068
reaction: metaid_0000085
area units: metaid_0000005
parameter: metaid_0000037
volume units: metaid_0000084
reaction: metaid_0000089
species: metaid_0000055
species: metaid_0000056
event: metaid_0000092
species: metaid_0000043
is described by: http://identifiers.org/pubmed/12376338
parameter: metaid_0000020
reaction: metaid_0000081
species: metaid_0000060
parameter: metaid_0000011
name: Sedaghat2002_InsulinSignalling_noFeedback
species: metaid_0000061
reaction: metaid_0000072
parameter: metaid_0000032
units def: metaid_0000099
parameter: metaid_0000023
reaction: metaid_0000084
parameter: metaid_0000035
is part of: hsa04910
parameter: metaid_0000008
species: metaid_0000059
occurs in: http://identifiers.org/taxonomy/9606
parameter: metaid_0000014
parameter: metaid_0000095
parameter: metaid_0000005
rule: metaid_0000066
species: metaid_0000047
reaction: metaid_0000074
parameter: metaid_0000026
reaction: metaid_0000078
parameter: metaid_0000017
reaction: metaid_0000070
rule: metaid_0000067
reaction: metaid_0000086
parameter: metaid_0000038
is: MODEL6526728774
parameter: metaid_0000029
reaction: metaid_0000082
event: metaid_0000093
species: metaid_0000046
species: metaid_0000053
compartment: metaid_0000097
species: metaid_0000054
species: metaid_0000049
parameter: metaid_0000012
parameter: metaid_0000041
parameter: metaid_0000003
reaction: metaid_0000073
parameter: metaid_0000024
parameter: metaid_0000015
rule: metaid_0000096
parameter: metaid_0000030
parameter: metaid_0000021
parameter: metaid_0000036
reaction: metaid_0000075
parameter: metaid_0000027
reaction: metaid_0000079

metaid_0000016
type: Parameter
constant: true
value: 4.16

metaid_0000007
type: Parameter
constant: true
value: 2500.0

metaid_0000050
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated once bound intracellular receptor

metaid_0000042
type: Compartment
is: GO:0005622
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000022
type: Parameter
constant: true
value: 0.13145

metaid_0000076
type: Reaction
kinetic law: 806247
product: 806235
reactant: 806223
is version of: GO:0031623
fast: false
reversible: true
name: Receptor transport

806235
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

806223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000046
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Phosphorylated once bound receptor

metaid_0000097
type: Compartment
is: GO:0009986
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000013
type: Parameter
constant: false
value: 0.0

metaid_0000028
type: Parameter
constant: false
value: 0.0

metaid_0000019
type: Parameter
constant: true
value: 10.0

metaid_0000098
type: SBMLUnitsDef
unit: 805959
name: femtomole

805959
type: SBMLUnit
exponent: 1.0
scale: -15
multipler: 1.0
kind: MOLE

metaid_0000034
type: Parameter
constant: true
value: 0.001155

metaid_0000088
type: Reaction
kinetic law: 806667
reactant: 806655
is version of: GO:0044257
fast: false
reversible: false
name: GLUT4 degradation

806655
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000058
type: Species
is version of: P14672
constant: false
boundary condition: false
has only substance units: false
initial concentration: 96.0
initial amount: NaN
in compartment: metaid_0000042
name: Intracellular GLUT4

metaid_0000063
type: Species
initial concentration: 0.29
constant: false
has only substance units: false
boundary condition: false
name: PI3,4P2
initial amount: NaN
is: CHEBI:16152
in compartment: metaid_0000042
is: C11554

metaid_0000025
type: Parameter
constant: true
value: 2.77

metaid_0000077
type: Reaction
kinetic law: 806271
product: 806259
is version of: GO:0032800
fast: false
reversible: false
name: Receptor synthesis

806259
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000048
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unbound unphosphorylated intracellular receptor

metaid_0000085
type: Reaction
kinetic law: 806583
product: 806571
reactant: 806559
is version of: GO:0006468
fast: false
reversible: true
name: Akt activation

806571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000060
type: Species
is version of: Q9Y243
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Activated Akt

806559
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000056
type: Species
is version of: Q9Y243
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unactivated Akt

metaid_0000037
type: Parameter
constant: true
value: 1.0

metaid_0000089
type: Reaction
kinetic law: 806703
product: 806691
reactant: 806679
is version of: GO:0006886
fast: false
reversible: true
name: GLUT4 translocation

806691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

metaid_0000064
type: Species
is version of: P14672
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: metaid_0000097
name: Cell surface GLUT4

806679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000055
type: Species
boundary condition: false
initial amount: NaN
in compartment: metaid_0000042
constant: false
is: C05981
initial concentration: 0.31
is: CHEBI:16618
name: PI3,4,5P3
has only substance units: false

metaid_0000092
type: Event
event assignment: 806727
trigger: 806715
notes: When time is greater than or equal to 15 minutes Insulin input is set to zero
use values from trigger time: true

metaid_0000043
type: Species
is: P01308
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E8
initial amount: NaN
in compartment: metaid_0000097
name: Insulin

806715
type: Trigger
persistant: true
initial value: true

metaid_0000020
type: Parameter
constant: false
value: 0.0

metaid_0000081
type: Reaction
kinetic law: 806427
reversible: true
is: GO:0004716
fast: true
modifier: 806403
is: http://identifiers.org/ec-code/2.7.10.1
name: IRS1 activation
product: 806391
modifier: 806415
reactant: 806379

metaid_0000047
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Phosphorylated twice bound receptor

806391
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000053
type: Species
is version of: P35568
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated IRS1

806379
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000052
type: Species
is version of: P35568
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1000.0
initial amount: NaN
in compartment: metaid_0000042
name: Unphosphorylated IRS1

metaid_0000011
type: Parameter
constant: true
value: 0.0021

metaid_0000061
type: Species
in compartment: metaid_0000042
name: IRS1- PI3 Kinase Complex
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
has part: Q8WYR1
has part: P35568
initial concentration: 0.0

metaid_0000072
type: Reaction
kinetic law: 806103
modifier: 806091
product: 806079
reactant: 806067
is version of: GO:0043559
fast: false
reversible: true
name: Insulin Binding

806079
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

806067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000032
type: Parameter
constant: false
value: 0.0

metaid_0000099
type: SBMLUnitsDef
unit: 805971
name: minute

805971
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000023
type: Parameter
constant: true
value: 42.15

metaid_0000084
type: Reaction
kinetic law: 806547
product: 806535
reactant: 806523
is version of: GO:0006661
fast: false
reversible: true
name: PI 3,4,5P3 generation

806535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

806523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000035
type: Parameter
constant: false
value: 0.0

metaid_0000008
type: Parameter
constant: true
value: 0.2

metaid_0000059
type: Species
is version of: Q8WYR1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: PI3 Kinase

metaid_0000014
type: Parameter
constant: true
value: 1.67E-18

metaid_0000095
type: Parameter
constant: false
value: 0.0

metaid_0000005
type: Parameter
constant: true
value: 6.0E-8

metaid_0000074
type: Reaction
kinetic law: 806175
product: 806163
reactant: 806151
is version of: GO:0031623
fast: false
reversible: true
name: Receptor endocytosis

806163
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

806151
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000044
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 900.0
initial amount: NaN
in compartment: metaid_0000097
name: Unbound Insulin Receptor

metaid_0000026
type: Parameter
constant: false
value: 0.0

metaid_0000078
type: Reaction
kinetic law: 806295
reactant: 806283
is version of: GO:0032801
fast: false
reversible: false
name: Receptor degradation

806283
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000017
type: Parameter
constant: true
value: 1.396

metaid_0000070
type: Reaction
kinetic law: 806019
modifier: 806007
product: 805995
reactant: 805983
is version of: GO:0043559
fast: false
reversible: true
name: Insulin binding

805995
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000045
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Unphosphorylated once bound receptor

805983
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000086
type: Reaction
kinetic law: 806619
product: 806607
reactant: 806595
is: GO:0007205
fast: false
reversible: true
name: PKC activation

806607
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

metaid_0000062
type: Species
is version of: P41743
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Activated PKC

806595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000057
type: Species
is version of: P41743
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unactivated PKC

metaid_0000038
type: Parameter
constant: true
value: 1.0

metaid_0000029
type: Parameter
constant: true
value: 6.9315

metaid_0000082
type: Reaction
fast: false
name: IRS1-PI3K complex formation
is version of: GO:0005515
product: 806463
is version of: GO:0043548
kinetic law: 806475
reactant: 806451
reversible: true
reactant: 806439

806463
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

806451
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

806439
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000093
type: Event
event assignment: 806751
trigger: 806739
notes: This is the condition to assign values to k5 as given in the appendix
use values from trigger time: true

806739
type: Trigger
persistant: true
initial value: true

metaid_0000054
type: Species
has only substance units: false
is: CHEBI:18348
initial concentration: 99.4
initial amount: NaN
is: C04637
in compartment: metaid_0000042
constant: false
name: PI4,5P2
boundary condition: false

metaid_0000049
type: Species
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated twice bound intracellular receptor

metaid_0000012
type: Parameter
constant: true
value: 2.1E-4

metaid_0000041
type: Parameter
constant: true
value: 5.0

metaid_0000003
type: Parameter
constant: true
value: 6.0E-8

metaid_0000073
type: Reaction
kinetic law: 806139
product: 806127
reactant: 806115
is version of: GO:0006470
fast: false
reversible: false
name: Receptor dephosphorylation

806127
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

806115
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000024
type: Parameter
constant: true
value: 2.961

metaid_0000015
type: Parameter
constant: true
value: 0.461

metaid_0000030
type: Parameter
constant: true
value: 0.00696

metaid_0000021
type: Parameter
constant: true
value: 1.39

metaid_0000036
type: Parameter
constant: true
value: 897.0

metaid_0000075
type: Reaction
kinetic law: 806211
product: 806199
reactant: 806187
is version of: GO:0031623
fast: false
reversible: true
name: Receptor transport

806199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

806187
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000027
type: Parameter
constant: true
value: 6.9315

metaid_0000079
type: Reaction
kinetic law: 806331
product: 806319
reactant: 806307
fast: false
reversible: false
name: Intracellular receptor dephosphorylation

806319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

806307
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000033
type: Parameter
constant: true
value: 0.11088

metaid_0000087
type: Reaction
kinetic law: 806643
product: 806631
is version of: GO:0006417
fast: false
reversible: false
name: GLUT4 synthesis

806631
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000039
type: Parameter
constant: true
value: 1.0

metaid_0000006
type: Parameter
constant: true
value: 20.0

metaid_0000040
type: Parameter
constant: true
value: 9.09091

metaid_0000094
type: Event
event assignment: 806775
trigger: 806763
use values from trigger time: true

806763
type: Trigger
persistant: true
initial value: true

metaid_0000018
type: Parameter
constant: true
value: 7.06E-4

metaid_0000071
type: Reaction
kinetic law: 806055
product: 806043
reactant: 806031
is version of: GO:0046777
fast: false
reversible: false
name: Receptor Autophosphorylation

806043
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

806031
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000009
type: Parameter
constant: true
value: 3.3333334E-4

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

metaid_0000083
type: Reaction
kinetic law: 806511
name: PI 3,4,5 P3 generation
reversible: true
is version of: GO:0016314
product: 806499
is: http://identifiers.org/ec-code/2.7.1.153
fast: false
is: R04545
reactant: 806487
is: http://identifiers.org/ec-code/3.1.3.67

806499
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

806487
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

W3 CDTF: Wed Jun 05 11:40:57 BST 2013

metaid_0000080
type: Reaction
kinetic law: 806367
product: 806355
reactant: 806343
fast: false
reversible: false
name: Intracellular receptor dephosphorylation

806355
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

806343
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000031
type: Parameter
constant: true
value: 0.167

metaid_0000004
type: Parameter
constant: true
value: 0.2

metaid_0000010
type: Parameter
constant: true
value: 0.003

W3 CDTF: Mon Aug 06 16:09:19 BST 2007