BIOMD0000000128
type: SBMLModel
rule: metaid_0000044
rule: metaid_0000089
rule: metaid_0000071
parameter: metaid_0000021
parameter: metaid_0000011
is described by: http://identifiers.org/pubmed/16434725
notes: The model is according to the paper Endothelin Action on Pituitary Lactotrophs: One Receptor, Many GTP-Binding Proteins Figure 1 has been simulated by MathSBML. The figure for the [Ca2+]i and [Ca2+]ER have been normalized in the paper.Original model comes from http://www.math.fsu.edu/~bertram/software/pituitary The units for parameters and species are varied from one to another, so I omit the unit definition here . Conductances in pS; currents in fA; Ca concentrations in uM; time in ms To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
length unit: length
occurs in: http://identifiers.org/taxonomy/10114
reaction: metaid_0000093
parameter: metaid_0000034
parameter: metaid_0000024
parameter: metaid_0000026
parameter: metaid_0000016
rule: metaid_0000056
reaction: metaid_0000092
is: MODEL6509019628
is version of: GO:0004962
parameter: metaid_0000029
parameter: metaid_0000037
parameter: metaid_0000039
parameter: metaid_0000019
parameter: metaid_0000061
parameter: metaid_0000051
parameter: metaid_0000053
rule: metaid_0000055
rule: metaid_0000065
parameter: metaid_0000064
rule: metaid_0000047
species: metaid_0000006
is version of: GO:0001664
parameter: metaid_0000010
name: Bertram2006_Endothelin
parameter: metaid_0000054
parameter: metaid_0000033
parameter: metaid_0000023
parameter: metaid_0000013
parameter: metaid_0000015
parameter: metaid_0000070
units def: metaid_0000082
parameter: metaid_0000050
rule: metaid_0000058
time units: metaid_0000018
rule: metaid_0000066
volume units: metaid_0000084
rule: metaid_0000057
rule: metaid_0000067
rule: metaid_0000091
parameter: metaid_0000088
parameter: metaid_0000036
parameter: metaid_0000038
parameter: metaid_0000028
parameter: metaid_0000018
species: metaid_0000007
parameter: metaid_0000031
curated: true
parameter: metaid_0000083
parameter: metaid_0000073
parameter: metaid_0000063
rule: metaid_0000041
is version of: GO:0007188
parameter: metaid_0000086
event: metaid_0000049
rule: metaid_0000084
substance units: metaid_0000099
rule: metaid_0000040
compartment: metaid_0000003
rule: metaid_0000087
rule: metaid_0000043
parameter: metaid_0000032
parameter: metaid_0000022
parameter: metaid_0000012
parameter: metaid_0000014
rule: metaid_0000068
reaction: metaid_0000094
parameter: metaid_0000045
parameter: metaid_0000035
parameter: metaid_0000025
parameter: metaid_0000027

metaid_0000021
type: Parameter
constant: true
value: 25.0

metaid_0000011
type: Parameter
constant: true
value: 70.0

metaid_0000093
type: Reaction
kinetic law: 281096
product: 281084
is version of: GO:0032469
fast: false
reversible: false

281084
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000007
type: Species
boundary condition: false
has only substance units: false
name: ER calcium concentration
is: CHEBI:29108
initial amount: NaN
in compartment: metaid_0000003
is: C00076
initial concentration: 260.0
constant: false

metaid_0000003
type: Compartment
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000034
type: Parameter
constant: false
value: NaN

metaid_0000024
type: Parameter
constant: true
value: 12.0

metaid_0000026
type: Parameter
constant: true
value: 5300.0

metaid_0000016
type: Parameter
constant: true
value: -16.0

metaid_0000092
type: Reaction
kinetic law: 281072
product: 281060
is version of: GO:0051480
fast: false
reversible: false

281060
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000006
type: Species
is: C00076
constant: false
initial amount: NaN
initial concentration: 0.3
has only substance units: false
name: cytosolic calcium concentration
boundary condition: false
is: CHEBI:29108
in compartment: metaid_0000003

metaid_0000029
type: Parameter
constant: true
value: 4.5E-6

metaid_0000037
type: Parameter
constant: false
value: NaN

metaid_0000039
type: Parameter
constant: false
value: NaN

metaid_0000019
type: Parameter
constant: true
value: 3500.0

metaid_0000061
type: Parameter
constant: false
value: NaN

metaid_0000051
type: Parameter
constant: false
value: NaN

metaid_0000053
type: Parameter
constant: false
value: NaN

metaid_0000064
type: Parameter
constant: false
value: NaN

metaid_0000010
type: Parameter
constant: true
value: -20.0

metaid_0000054
type: Parameter
constant: false
value: NaN

metaid_0000033
type: Parameter
constant: true
value: 0.4

metaid_0000023
type: Parameter
constant: true
value: -20.0

metaid_0000013
type: Parameter
constant: true
value: 0.4

metaid_0000015
type: Parameter
constant: true
value: 0.15

metaid_0000070
type: Parameter
constant: false
value: NaN

metaid_0000082
type: SBMLUnitsDef
unit: 281048
name: millisecond

281048
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

metaid_0000050
type: Parameter
constant: false
value: NaN

metaid_0000088
type: Parameter
constant: false
value: -60.0
name: voltage

metaid_0000036
type: Parameter
constant: false
value: NaN

metaid_0000038
type: Parameter
constant: false
value: NaN

metaid_0000028
type: Parameter
constant: true
value: 0.01

metaid_0000018
type: Parameter
constant: true
value: 20.0

metaid_0000031
type: Parameter
constant: true
value: 0.35

metaid_0000083
type: Parameter
constant: false
value: 0.0

metaid_0000073
type: Parameter
notes: Set cAMPlow=0.2 for nM ET, and cAMPlow=0.5 for pM ET
constant: true
value: 0.2

metaid_0000063
type: Parameter
constant: false
value: NaN

metaid_0000086
type: Parameter
constant: false
value: 1.0
name: variable for direct inhibition of secretion

metaid_0000049
type: Event
event assignment: 281168
event assignment: 281156
event assignment: 281144
trigger: 281132
notes: At time 1 minute a nanomolar concentration of endothelin is added.
is version of: GO:0004962
use values from trigger time: true
name: ET-1 switch

metaid_0000079
type: Parameter
constant: false
value: 0.0

metaid_0000045
type: Parameter
constant: false
value: 1000.0

metaid_0000048
type: Parameter
constant: false
value: 0.0

281132
type: Trigger
persistant: true
initial value: true

metaid_0000032
type: Parameter
constant: true
value: 0.5

metaid_0000022
type: Parameter
constant: true
value: 2000.0

metaid_0000012
type: Parameter
constant: true
value: 20.0

metaid_0000014
type: Parameter
constant: true
value: 10.0

metaid_0000094
type: Reaction
kinetic law: 281120
product: 281108
is version of: GO:0030817
is version of: GO:0004016
fast: false
reversible: false

281108
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000009
type: Species
is: C00575
is: CHEBI:17489
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000003

metaid_0000035
type: Parameter
constant: false
value: NaN

metaid_0000025
type: Parameter
constant: true
value: 1.25

metaid_0000027
type: Parameter
constant: true
value: 0.01

metaid_0000017
type: Parameter
constant: true
value: -75.0

metaid_0000069
type: Parameter
constant: true
value: 0.5

metaid_0000090
type: Parameter
constant: false
value: 0.0
name: delayed rectifier activation

metaid_0000030
type: Parameter
constant: true
value: 5.0E-4

metaid_0000020
type: Parameter
constant: true
value: 5.0

W3 CDTF: Fri Aug 03 14:17:36 BST 2007

metaid_0000072
type: Parameter
constant: true
value: 20000.0

metaid_0000062
type: Parameter
constant: false
value: NaN

metaid_0000052
type: Parameter
constant: false
value: NaN

ORG:
  orgname: BNMC
n:
  given: Enuo
  family: He

W3 CDTF: Thu Jul 05 17:31:29 BST 2012