BIOMD0000000121
type: SBMLModel
parameter: metaid_0000020
parameter: metaid_0000019
length unit: length
compartment: metaid_0000003
units def: metaid_0000049
species: metaid_0000007
parameter: metaid_0000025
parameter: metaid_0000015
volume units: metaid_0000084
is: MODEL2898180293
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reaction: metaid_0000042
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species: metaid_0000004
occurs in: http://identifiers.org/taxonomy/10141
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substance units: metaid_0000050
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area units: metaid_0000005
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curated: true
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parameter: metaid_0000028
species: metaid_0000005
rule: metaid_0000039
created:
  W3 CDTF: Wed Jun 20 10:51:21 BST 2007
parameter: metaid_0000023
parameter: metaid_0000012
parameter: metaid_0000027
notes: This model is according to the paper Cellular consequences of HEGR mutations in the long QT syndrome: precursors to sudden cardiac death. The author used Markovian model of cardiac Ikr in the paper. Figure4B in the paper has been reproduced using CellDesigner3.5.1. The cell is depolarized to the indicated test potential for 250ms (from 50ms to 300ms) from a holding potential of -40mV and then repolarized to -40mV. Change the value for vtest from -30,-20,-10,0,10,20,30,40 for each simulation in order to produce the different cureve in the paper. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
time units: metaid_0000047
is homolog to: http://identifiers.org/omim/152427
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is version of: GO:0005251
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species: metaid_0000008
name: Clancy2001_Kchannel
creator:
  ORG:
    orgname: BNMC
  n:
    given: Enuo
    family: He
rule: metaid_0000031
units def: metaid_0000047
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parameter: metaid_0000009
units def: metaid_0000050
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modified:
  W3 CDTF: Thu Jul 05 17:45:33 BST 2012
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reaction: metaid_0000043
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parameter: metaid_0000011
parameter: metaid_0000026
is described by: http://identifiers.org/pubmed/11334834
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is version of: GO:0043266

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type: Parameter
constant: false
value: NaN

metaid_0000019
type: Parameter
constant: false
value: NaN
name: membrane_conductance

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spatial dimensions: 3.0

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kind: VOLT

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name: OpenState

metaid_0000025
type: Parameter
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metaid_0000015
type: Parameter
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name: test_potential

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type: Reaction
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is version of: GO:0043266
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reversible: true
name: c2-c1 transition

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notes: when t > 300, v=vhold.
use values from trigger time: true

metaid_0000033
type: Parameter
notes: when (t gt 0) and ( t lt 50), v=vhold=-40
constant: false
value: -40.0
name: membrane_potential

119484
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value: 140.0
name: introcellular K

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metaid_0000023
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metaid_0000012
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value: 5.4
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metaid_0000009
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name: gas constant

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reversible: true
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metaid_0000022
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metaid_0000011
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name: temperature

metaid_0000026
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name: cardiac delayed rectifier current

metaid_0000046
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notes: when ( t gt 50 ) and ( t lt 300 ), v=vtest
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use values from trigger time: true

119460
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