BIOMD0000000117
type: SBMLModel
parameter: metaid_0000018
is version of: GO:0048763
reaction: metaid_0000031
parameter: metaid_0000007
parameter: metaid_0000033
parameter: metaid_0000013
parameter: metaid_0000017
creator:
  ORG:
    orgname: BNMC
  n:
    given: Enuo
    family: He
parameter: metaid_0000006
volume units: metaid_0000084
compartment: metaid_0000025
substance units: metaid_0000035
created:
  W3 CDTF: Tue May 22 14:36:51 BST 2007
name: Dupont1991_CaOscillation
compartment: metaid_0000023
reaction: metaid_0000029
is described by: http://identifiers.org/pubmed/1647878
reaction: metaid_0000026
reaction: metaid_0000028
rule: metaid_0000030
units def: metaid_0000035
time units: metaid_0000048
parameter: metaid_0000012
parameter: metaid_0000016
event: metaid_0000034
is version of: GO:0019722
parameter: metaid_0000009
reaction: metaid_0000032
notes: This model is according to the paper Signal-induced Ca2+ oscillations: Properties of a model based on Ca2+-induced Ca2+ release. Figure4B in the paper has been reproduced by RoadRunner and MathSBML. Damped Ca2+ oscillations elicited by a transient pulse of InsP3 applied intracellularly to a resting, non-oscillatory cell. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
length unit: length
is: MODEL0466937756
area units: metaid_0000005
curated: true
modified:
  W3 CDTF: Thu Jul 05 17:48:14 BST 2012
species: metaid_0000004
reaction: metaid_0000027
parameter: metaid_0000011
parameter: metaid_0000015
species: metaid_0000005
parameter: metaid_0000019
parameter: metaid_0000008
parameter: metaid_0000014
occurs in: http://identifiers.org/taxonomy/131567
compartment: metaid_0000024
parameter: metaid_0000010

metaid_0000018
type: Parameter
constant: true
value: 4.0
name: stimulation time

metaid_0000031
type: Reaction
kinetic law: 286867
product: 286854
reactant: 286842
is version of: GO:0007204
is version of: GO:0006816
fast: false
reversible: false
name: Release of Ca from the pool into the cytosol

286854
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000004
type: Species
is: C00076
initial concentration: 0.1
boundary condition: false
constant: false
name: Ca in the cytosol
has only substance units: false
initial amount: NaN
in compartment: metaid_0000024
is: CHEBI:29108

metaid_0000024
type: Compartment
is version of: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0

286842
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000005
type: Species
has only substance units: false
is: CHEBI:29108
is: C00076
constant: false
initial concentration: 1.4
name: Ca in the InsP3-insensitive pool
initial amount: NaN
in compartment: metaid_0000025
boundary condition: false

metaid_0000025
type: Compartment
is version of: GO:0044424
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000007
type: Parameter
constant: true
value: 7.3

metaid_0000033
type: Parameter
notes: when flag=0, beta=0, flag=1, beta=beta_f*exp[-0.2*(t-tp)]
constant: false
value: 0.0

metaid_0000013
type: Parameter
constant: true
value: 1.0

metaid_0000017
type: Parameter
constant: true
value: 4.0

metaid_0000006
type: Parameter
constant: true
value: 1.0

metaid_0000035
type: SBMLUnitsDef
unit: 286709
name: microM

286709
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000023
type: Compartment
is version of: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000029
type: Reaction
kinetic law: 286757
product: 286745
is version of: GO:0007204
is version of: GO:0006816
fast: false
reversible: false
name: Constant input of Ca from the extracellular medium

286745
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000026
type: Reaction
kinetic law: 286794
product: 286782
reactant: 286770
is version of: GO:0007204
is version of: GO:0006816
fast: false
reversible: false
name: Leak Ca from pool to cytosol

286782
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

286770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000028
type: Reaction
kinetic law: 286733
product: 286721
is version of: GO:0007204
is version of: GO:0006816
fast: false
reversible: false
name: InsP3 modulated release of Ca from the InsP3 sensitive store

286721
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000030
notes: According to the legend of Figure4B, beta decays from the initial value beta_f=96% according to the equation beta=beta_f*exp[-0.2*(t-tp)]. and tp=4s.

metaid_0000012
type: Parameter
constant: true
value: 1.0

metaid_0000016
type: Parameter
constant: true
value: 2.0

metaid_0000034
type: Event
event assignment: 286915
trigger: 286903
use values from trigger time: true

286903
type: Trigger
persistant: true
initial value: true

metaid_0000009
type: Parameter
constant: true
value: 500.0

metaid_0000032
type: Reaction
kinetic law: 286891
reactant: 286879
is version of: GO:0051481
is version of: GO:0006816
fast: false
reversible: false
name: Transport of cytosolic ca into the extracellular medium

286879
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000027
type: Reaction
is version of: GO:0006816
is version of: GO:0051481
is version of: GO:0005388
reactant: 286806
product: 286818
name: Pumping Ca into the InsP3-insensitive store
reversible: false
kinetic law: 286830
fast: false

286806
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

286818
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000011
type: Parameter
constant: true
value: 0.9

metaid_0000015
type: Parameter
constant: true
value: 2.0

metaid_0000019
type: Parameter
notes: saturation function of the InsP3 receptor
constant: false
value: 0.0

metaid_0000008
type: Parameter
constant: true
value: 65.0

metaid_0000014
type: Parameter
constant: true
value: 10.0

metaid_0000010
type: Parameter
constant: true
value: 2.0