BIOMD0000000107
type: SBMLModel
parameter: metaid_0000003
substance units: metaid_0000084
notes: The model reproduces the time profile of active MPF at cyclin concentration of 100nM as depicted in Fig 4A of the paper. Please note that active MPF and cyclin concentrations in the paper are given relative to total cdc2 concentration (100nM). Active MPF (dimer_p) is the cyclin-cdc2 complex that is phosphorylated at Thr161. The model was successfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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reaction: metaid_0000078
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parameter: metaid_0000028
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parameter: metaid_0000016
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parameter: metaid_0000035
reaction: metaid_0000069
parameter: metaid_0000010
parameter: metaid_0000023
parameter: metaid_0000014
reaction: metaid_0000070
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is homolog to: REACT 152
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reaction: metaid_0000081
reaction: metaid_0000061
length unit: length
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curated: true
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parameter: metaid_0000013
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is described by: http://identifiers.org/pubmed/8126097
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metaid_0000037
type: Compartment
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size: 1.0
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metaid_0000027
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metaid_0000074
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metaid_0000043
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metaid_0000046
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818289
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metaid_0000016
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metaid_0000031
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metaid_0000007
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metaid_0000065
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name: Tyr15 phosphorylation
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metaid_0000069
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metaid_0000023
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metaid_0000014
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metaid_0000070
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818565
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metaid_0000048
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metaid_0000026
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metaid_0000073
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818661
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metaid_0000077
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name: cdc25 deactivation

818781
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species: metaid_0000044

metaid_0000044
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metaid_0000086
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818252
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metaid_0000081
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818901
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metaid_0000061
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product: 818264
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name: cyclin synthesis

818264
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metaid_0000051
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metaid_0000076
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reversible: false
name: cdc25 activation

818745
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metaid_0000006
type: Parameter
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metaid_0000064
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reversible: false
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metaid_0000034
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metaid_0000068
type: Reaction
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reversible: false
name: Tyr15 dephosphorylation
is: http://identifiers.org/ec-code/3.1.3.48
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818493
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818505
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metaid_0000022
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constant: true
value: 0.1

metaid_0000013
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metaid_0000018
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metaid_0000050
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name: wee1

metaid_0000021
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metaid_0000049
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boundary condition: false
has only substance units: false
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metaid_0000025
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value: 0.0133

metaid_0000072
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fast: false
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reversible: false
kinetic law: 818649
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818625
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species: metaid_0000041

818637
type: SpeciesReference
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metaid_0000080
type: Reaction
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modifier: 818877
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fast: false
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818865
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metaid_0000136
type: Parameter
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value: 0.0

metaid_0000075
type: Reaction
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reactant: 818721
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fast: false
reversible: false
name: cyclin degradation

818721
type: SpeciesReference
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metaid_0000005
type: Parameter
constant: true
value: 1.0

metaid_0000079
type: Reaction
kinetic law: 818853
reactant: 818841
fast: false
reversible: false
name: wee1 activation

818841
type: SpeciesReference
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species: metaid_0000045

metaid_0000052
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: ubiquitin conjugating enzyme

metaid_0000137
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metaid_0000083
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name: ubiquitin conjugating enzyme deactivation

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species: metaid_0000047

metaid_0000063
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modifier: 818337
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fast: false
reversible: false
name: cyclin-cdc2 dimer formation

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metaid_0000033
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metaid_0000009
type: Parameter
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value: 0.1

metaid_0000029
type: Parameter
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metaid_0000067
type: Reaction
kinetic law: 818481
reactant: 818469
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation

818469
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metaid_0000012
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metaid_0000017
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metaid_0000030
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metaid_0000032
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metaid_0000036
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metaid_0000020
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metaid_0000024
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metaid_0000015
type: Parameter
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metaid_0000071
type: Reaction
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product: 818601
reactant: 818589
is version of: GO:0000079
fast: false
reversible: false
name: Thr161 dephosphorylation

818601
type: SpeciesReference
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818589
type: SpeciesReference
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W3 CDTF: Thu Jul 05 15:43:50 BST 2012

W3 CDTF: Thu Apr 05 09:42:03 BST 2007

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri