This model represents the non-competitive binding of XIAP to Casapase-3 and Caspase-9. In other words, XIAP mediated feedback is abolished in this model. The authors state that this leads to bistable-reversible behaviour as depicted in Fig 4C. The wild-type model displays a bistable-irreversible profile. This shows that irreversibility requires XIAP mediated feedback. The model was tested on MathSBML. However, please note that the paper does not contain any figure that corresponds to simulation of the Non-Competitive model. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Binding of Apaf-Caspase 9 to cleaved Caspase 3-Xiap
Apaf-1-Caspase9-Xiap-Caspase3_star degradation
Cleaved-Caspase 3 binding with Xiap-Caspase 9
Apaf-Xiap-cleaved Caspase 9 binding with cleaved Caspase 3
Binding of cleaved Caspase 9 to cleaved Caspase 3-Xiap
Caspase 9 cleavage by cleaved caspase 3 when Apaf-1 is bound
Binding of Caspase 9-Xiap-cleaved Caspase 3 with Apaf
Caspase9_star-Xiap-Caspase3_star degradation
Binding of Caspase 9 to cleaved Caspase 3-Xiap
Cleaved-Caspase 3 binding with Apaf-Xiap-Caspase 9
Binding of cleaved Caspase 9-Xiap-cleaved Caspase 3 with Apaf
Apaf-1 Caspase 9 cleaved-Xiap degradation
Caspase 3 cleavage by cleaved Caspase 9 - Apaf-1
Apaf-1-Caspase9_star-Xiap-Caspase3_star degradation
Cleaved-Caspase 3 binding with Cleaved-Xiap-Caspase 9
Binding of cleaved Caspase 9-Apaf-1 to cleaved Caspase 3-Xiap