BIOMD0000000098
type: SBMLModel
compartment: metaid_0000030
parameter: metaid_0000013
parameter: metaid_0000012
units def: metaid_0000032
is version of: GO:0005220
reaction: metaid_0000022
compartment: metaid_0000016
is described by: http://identifiers.org/pubmed/2304911
substance units: metaid_0000031
created:
  W3 CDTF: Wed Mar 21 15:41:17 GMT 2007
parameter: metaid_0000008
reaction: metaid_0000023
length unit: length
notes: The model reproduces the time profile of cytosolic and intracellular calcium as depicted in the upper panel of Fig 2 in the paper. The model was successfully tested on MathSBML and Jarnac. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see theterms of use . To cite BioModels Database, please useLe Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
parameter: metaid_0000003
species: metaid_0000018
parameter: metaid_0000010
parameter: metaid_0000035
units def: metaid_0000031
name: Goldbeter1990_CalciumSpike_CICR
parameter: metaid_0000006
reaction: metaid_0000021
is: MODEL4519937652
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
parameter: metaid_0000007
units def: metaid_0000034
is version of: GO:0006816
reaction: metaid_0000020
curated: true
occurs in: http://identifiers.org/taxonomy/131567
reaction: metaid_0000025
parameter: metaid_0000015
species: metaid_0000019
area units: metaid_0000005
volume units: metaid_0000004
parameter: metaid_0000005
reaction: metaid_0000024
parameter: metaid_0000009
units def: metaid_0000033
modified:
  W3 CDTF: Fri Apr 20 20:24:28 BST 2012
time units: metaid_0000173
parameter: metaid_0000014
parameter: metaid_0000004

metaid_0000030
type: Compartment
is: GO:0005783
constant: true
size: 1.0
spatial dimensions: 3.0
name: store

metaid_0000013
type: Parameter
constant: true
units: metaid_0000034
value: 0.9

metaid_0000034
type: SBMLUnitsDef
unit: 431134
unit: 431121
name: uM

431134
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

431121
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000012
type: Parameter
constant: true
units: metaid_0000034
value: 2.0

metaid_0000032
type: SBMLUnitsDef
unit: 431097
unit: 431085
unit: 431073
name: uM_per_sec

431097
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

431085
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

431073
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000022
type: Reaction
kinetic law: 431218
product: 431206
reactant: 431194
is: GO:0032470
fast: false
reversible: false
name: ATP driven Ca pumping into store

431206
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000019
type: Species
is: C00076
is: CHEBI:29108
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.6
initial amount: NaN
in compartment: metaid_0000030

431194
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000018
type: Species
is: C00076
is: CHEBI:29108
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.15
initial amount: NaN
in compartment: metaid_0000016

metaid_0000016
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol

metaid_0000031
type: SBMLUnitsDef
unit: 431061
name: micromole

431061
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000008
type: Parameter
constant: true
units: metaid_0000034
value: 1.0

metaid_0000023
type: Reaction
kinetic law: 431254
product: 431242
reactant: 431230
is: GO:0048763
is: GO:0007204
fast: false
reversible: false
name: ATP driven pumping into cytosol

431242
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

431230
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000003
type: Parameter
constant: true
units: metaid_0000032
value: 1.0

metaid_0000010
type: Parameter
constant: true
units: dimensionless
value: 2.0

metaid_0000035
type: Parameter
constant: true
units: dimensionless
value: 4.0

metaid_0000006
type: Parameter
constant: true
units: metaid_0000032
value: 65.0

metaid_0000021
type: Reaction
kinetic law: 431182
product: 431170
is: GO:0005220
fast: false
reversible: false
name: InsP3 dependent Ca influx

431170
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000007
type: Parameter
constant: true
units: dimensionless
value: 2.0

metaid_0000020
type: Reaction
kinetic law: 431158
product: 431146
is: GO:0006816
fast: false
reversible: false
name: Ca influx

431146
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000025
type: Reaction
kinetic law: 431314
reactant: 431302
is: GO:0006816
fast: false
reversible: false
name: Ca efflux

431302
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000015
type: Parameter
constant: true
units: metaid_0000033
value: 10.0

metaid_0000033
type: SBMLUnitsDef
unit: 431109
name: sec_inv

431109
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

metaid_0000005
type: Parameter
constant: true
units: dimensionless
value: 0.301

metaid_0000024
type: Reaction
kinetic law: 431290
product: 431278
reactant: 431266
is: GO:0007204
fast: false
reversible: false
name: Ca leak

431278
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

431266
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000009
type: Parameter
constant: true
units: metaid_0000032
value: 500.0

metaid_0000014
type: Parameter
constant: true
units: metaid_0000033
value: 1.0

metaid_0000004
type: Parameter
constant: true
units: metaid_0000032
value: 7.3