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type: SBMLModel
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notes: The model reproduces Fig 2B, D, F, and 2H. The dynamics correspond to a stimulus of 1 U/ml of thrombin which is equal to 0.01 uM. Phosphorylated MLC is the sum of pMLC (s359) and ppMLC (s360). A slight discrepancy in peak values of species between the figure in the paper and simulation result might be due to different initial conditions in the two sets. The model was successfully tested on MathSBML. It is possible to simulate the model on other software that do not support "Events" at this time by removing the "listOfEvents" and substituting a value of 0.01 for thrombin (s2). This does not change the model very much. With the latter format, the model was also successfully tested on Copasi. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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120806
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096474
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120858
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121374
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098404
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098380
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121086
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098368
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121237
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098356
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121049
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120841
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121482
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reversible: true
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100114
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100102
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100078
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120961
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100066
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121362
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098151
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120848
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098199
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098187
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098163
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098139
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121411
type: Reaction
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product: 098971
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reversible: false
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099007
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098983
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121054
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098971
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121036
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is: C00076
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initial amount: NaN
is: CHEBI:29108

120781
type: Compartment
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constant: true
size: 0.1
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098959
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121105
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is: C00076

121382
type: Reaction
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098525
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121227
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098513
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species: 120893

120893
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is: CHEBI:18348
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initial amount: NaN
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098573
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098561
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098549
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098501
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metaid_0000226
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096313
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121434
type: Reaction
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reversible: true
name: D1-5

099295
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099283
type: LocalParameter
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099259
type: SpeciesReference
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099247
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099235
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120917
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121058
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121397
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098766
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098742
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120896
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098730
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120876
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121326
type: Reaction
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product: 097607
product: 097595
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097631
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097607
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097595
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097583
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121650
type: Reaction
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103106
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121163
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103094
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103082
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103154
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103142
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103130
type: LocalParameter
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121532
type: Reaction
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reactant: 100920
reactant: 100908
is: GO:0017020
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reversible: true
name: E1-12

100969
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100957
type: LocalParameter
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100932
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120993
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initial concentration: 0.0
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100920
type: SpeciesReference
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100908
type: SpeciesReference
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121243
type: Species
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initial concentration: 0.7
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name: MYPT1_PPase

121526
type: Reaction
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reactant: 100787
is: GO:0006470
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reversible: false
name: E1-10

100823
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100799
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100787
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120964
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121630
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reactant: 102710
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102710
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121151
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102734
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102758
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102722
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121181
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121555
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kinetic law: 101355
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101331
type: SpeciesReference
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101391
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101379
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101367
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101319
type: SpeciesReference
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101343
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121722
type: Reaction
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reversible: true
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104091
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121195
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104055
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104043
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121379
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098428
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098416
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098489
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098477
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098465
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098440
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121232
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121623
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102541
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102614
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102601
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102589
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102565
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102553
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121471
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099982
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099970
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metaid_0000225
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096424
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096412
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096400
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099946
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099934
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099922
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121607
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102305
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121136
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102357
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102331
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102318
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121166
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121503
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100378
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120984
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100354
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100426
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100414
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100402
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100366
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121386
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098646
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098609
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098622
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098597
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120883
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098585
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121465
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099802
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099790
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099850
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099838
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099814
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121219
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121444
type: Reaction
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099511
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099499
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099475
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099463
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099451
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121703
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103814
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103850
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103826
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103802
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121175
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121529
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100896
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100884
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100860
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120989
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100848
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100836
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121339
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097861
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097849
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120809
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097885
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097837
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097825
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121611
type: Reaction
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product: 102383
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reactant: 102370
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102383
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102370
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121139
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102396
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102421
type: LocalParameter
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121536
type: Reaction
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product: 100993
reactant: 100981
is: GO:0006470
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reversible: false
name: E1-13

101017
type: LocalParameter
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100993
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100981
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121045
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121157
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121346
type: Reaction
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name: A1-1
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is: GO:0004930
reversible: true
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097909
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097921
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097897
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121073
type: Species
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initial amount: NaN
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097957
type: LocalParameter
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097945
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121513
type: Reaction
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fast: false
reactant: 100607
kinetic law: 100643
product: 100631
is: GO:0004697
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product: 100619

100607
type: SpeciesReference
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100655
type: LocalParameter
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100631
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100619
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121077
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121391
type: Reaction
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name: C2-2.2
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product: 098670
kinetic law: 098706
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is: R03435
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is: GO:0004435
product: 098682
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098694
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098658
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098670
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098718
type: LocalParameter
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098682
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121539
type: Reaction
kinetic law: 101066
product: 101053
reactant: 101041
reactant: 101029
is: GO:0032027
fast: false
reversible: true
name: F2-1.1

101103
type: LocalParameter
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101091
type: LocalParameter
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101079
type: LocalParameter
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101053
type: SpeciesReference
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121012
type: Species
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101041
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101029
type: SpeciesReference
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120869
type: Species
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initial concentration: 0.042
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name: Rho-kinase

120907
type: Species
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name: Rho_GEF_active

121601
type: Reaction
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product: 102175
reactant: 102149
reactant: 102162
kinetic law: 102188
is: GO:0017018
fast: false
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is: GO:0032027

102175
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121142
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boundary condition: false
has part: P05976

102149
type: SpeciesReference
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102162
type: SpeciesReference
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102227
type: LocalParameter
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value: 9.317
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102214
type: LocalParameter
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102201
type: LocalParameter
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name: Km

121414
type: Reaction
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kinetic law: 099055
product: 099043
name: D1-3
reversible: true
is: GO:0005516
reactant: 099031
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099079
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099067
type: LocalParameter
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099043
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099031
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099019
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121627
type: Reaction
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is: GO:0032027
is: GO:0019901
reversible: true
reactant: 102638
product: 102650
reactant: 102626
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102698
type: LocalParameter
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102686
type: LocalParameter
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102674
type: LocalParameter
units: metaid_0000227
value: 148.08
name: Km

102638
type: SpeciesReference
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species: 120928

102650
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species: 121145

121145
type: Species
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constant: false
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102626
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metaid_0000232
type: Event
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trigger: 104103
use values from trigger time: true

104103
type: Trigger
persistant: true
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121497
type: Reaction
kinetic law: 100306
product: 100294
reactant: 100282
reactant: 100270
is: GO:0051928
fast: false
reversible: true
name: D2-1.1

100342
type: LocalParameter
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100330
type: LocalParameter
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100318
type: LocalParameter
units: metaid_0000227
value: 0.04
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100294
type: SpeciesReference
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species: 121110

121110
type: Species
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is: CHEBI:29108
boundary condition: false
is: C00076
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constant: false
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initial amount: NaN
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100282
type: SpeciesReference
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species: 121026

100270
type: SpeciesReference
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120976
type: Species
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initial amount: NaN
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constant: false
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121577
type: Reaction
fast: false
kinetic law: 101727
is: GO:0004674
is: GO:0017020
reactant: 101691
product: 101703
reversible: false
product: 101715
is: http://identifiers.org/ec-code/2.7.11.1
name: F2-14.2

101739
type: LocalParameter
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value: 1.46
name: Vmax

101691
type: SpeciesReference
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species: 121130

101703
type: SpeciesReference
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species: 120869

101715
type: SpeciesReference
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species: 121247

121643
type: Reaction
reactant: 102914
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reactant: 102926
kinetic law: 102950
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product: 102938
is: GO:0032027
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102914
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species: 121008

102926
type: SpeciesReference
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102986
type: LocalParameter
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102974
type: LocalParameter
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102962
type: LocalParameter
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value: 10.019
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102938
type: SpeciesReference
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species: 121175

121680
type: Reaction
name: F2-5.4.2
is: R03150
product: 103574
reactant: 103562
kinetic law: 103598
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reversible: false
fast: false
is: http://identifiers.org/ec-code/2.7.11.18
product: 103586

103574
type: SpeciesReference
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species: 121127

103562
type: SpeciesReference
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species: 121163

103610
type: LocalParameter
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103586
type: SpeciesReference
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species: 120941

121294
type: Reaction
kinetic law: 097127
product: 097115
reactant: 097103
reactant: 097091
is: GO:0031684
fast: false
reversible: false
name: A1-9

097139
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097115
type: SpeciesReference
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097103
type: SpeciesReference
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species: 121086

097091
type: SpeciesReference
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species: 121045

121274
type: Reaction
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is: GO:0015057
reactant: 096704
reactant: 096716
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kinetic law: 096742
product: 096729
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096704
type: SpeciesReference
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species: 121097

096716
type: SpeciesReference
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species: 120812

096768
type: LocalParameter
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096755
type: LocalParameter
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096729
type: SpeciesReference
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species: 121090

121090
type: Species
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121677
type: Reaction
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is: R03150
product: 103526
reactant: 103502
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103550
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103526
type: SpeciesReference
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species: 120941

103502
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103514
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120862
type: Species
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121646
type: Reaction
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kinetic law: 103034
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103022
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102998
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103070
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103058
type: LocalParameter
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103046
type: LocalParameter
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103010
type: SpeciesReference
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121281
type: Reaction
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product: 096897
reactant: 096884
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reversible: false
name: A1-6

096923
type: LocalParameter
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096897
type: SpeciesReference
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096884
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120825
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121316
type: Reaction
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product: 097487
product: 097475
reactant: 097463
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097511
type: LocalParameter
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097487
type: SpeciesReference
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097475
type: SpeciesReference
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097463
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120902
type: Species
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121620
type: Reaction
kinetic law: 102517
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102529
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102505
type: SpeciesReference
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102493
type: SpeciesReference
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121559
type: Reaction
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product: 101427
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reactant: 101415
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101403
type: SpeciesReference
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101475
type: LocalParameter
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101463
type: LocalParameter
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101451
type: LocalParameter
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101427
type: SpeciesReference
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121115
type: Species
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101415
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121633
type: Reaction
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kinetic law: 102806
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102794
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102770
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102818
type: LocalParameter
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102782
type: SpeciesReference
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121712
type: Reaction
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product: 103935
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reversible: false
reactant: 103923
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product: 103947
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103971
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103935
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103923
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103947
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121420
type: Reaction
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product: 099115
reactant: 099103
reactant: 099091
is: GO:0005509
fast: false
reversible: true
name: D1-4

099151
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099139
type: LocalParameter
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099115
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099103
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099091
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121453
type: Reaction
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product: 099609
reactant: 099596
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reversible: true
name: E1-1

099645
type: LocalParameter
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099633
type: LocalParameter
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099609
type: SpeciesReference
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120950
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099596
type: SpeciesReference
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121719
type: Reaction
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modifier: 104007
product: 103995
reactant: 103983
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reversible: true
name: D3-3

104031
type: LocalParameter
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103995
type: SpeciesReference
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103983
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121190
type: Species
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121668
type: Reaction
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name: F2-6.4.1
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fast: false
kinetic law: 103454
reactant: 103418
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reactant: 103430
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103442
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103490
type: LocalParameter
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103478
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103466
type: LocalParameter
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value: 10.019
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103418
type: SpeciesReference
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103430
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121566
type: Reaction
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kinetic law: 101583
reversible: false
product: 101559
product: 101571
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101595
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101559
type: SpeciesReference
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101571
type: SpeciesReference
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101547
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121371
type: Reaction
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product: 098307
name: C1-1
reactant: 098284
is: GO:0005509
reactant: 098295
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kinetic law: 098320
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098307
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098284
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098295
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098344
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098331
type: LocalParameter
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121278
type: Reaction
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reversible: false
is: GO:0003924
fast: false
name: A1-4
product: 096845
product: 096832
kinetic law: 096858
product: 096820
product: 096807
is: GO:0031684
reactant: 096781

096794
type: SpeciesReference
stoichiometry: 1.0
species: 120845

096845
type: SpeciesReference
stoichiometry: 1.0
species: 121045

096832
type: SpeciesReference
stoichiometry: 1.0
species: 120851

096871
type: LocalParameter
units: metaid_0000223
value: 0.01
name: kf

096820
type: SpeciesReference
stoichiometry: 1.0
species: 120834

096807
type: SpeciesReference
stoichiometry: 1.0
species: 120848

096781
type: SpeciesReference
stoichiometry: 1.0
species: 121090

121520
type: Reaction
product: 100739
is: GO:0004699
kinetic law: 100763
product: 100751
reversible: false
reactant: 100727
is: http://identifiers.org/ec-code/2.7.11.13
fast: false
name: E2-1.2.1

100739
type: SpeciesReference
stoichiometry: 1.0
species: 120950

100775
type: LocalParameter
units: metaid_0000224
value: 3.94
name: Vmax

100751
type: SpeciesReference
stoichiometry: 1.0
species: 121021

100727
type: SpeciesReference
stoichiometry: 1.0
species: 120976

121430
type: Reaction
kinetic law: 099199
product: 099187
reactant: 099175
reactant: 099163
is: GO:0005509
fast: false
reversible: true
name: D1-6

099223
type: LocalParameter
units: metaid_0000224
value: 500.0
name: kb

099211
type: LocalParameter
units: metaid_0000223
value: 10.0
name: kf

099187
type: SpeciesReference
stoichiometry: 1.0
species: 120923

120923
type: Species
name: 4Ca_super_2_plus__endsuper_.CaM
is: P62158
boundary condition: false
in compartment: 120775
initial concentration: 0.0
constant: false
is: C00391
is: CHEBI:29108
is: C00076
has only substance units: false
initial amount: NaN

099175
type: SpeciesReference
stoichiometry: 1.0
species: 121026

099163
type: SpeciesReference
stoichiometry: 1.0
species: 120920

121492
type: Reaction
kinetic law: 100246
product: 100234
reactant: 100222
is: GO:0030163
fast: false
reversible: false
name: E1-2

100258
type: LocalParameter
units: metaid_0000224
value: 4.63E-5
name: kf

100234
type: SpeciesReference
stoichiometry: 1.0
species: 120970

100222
type: SpeciesReference
stoichiometry: 1.0
species: 120950

121407
type: Reaction
is: GO:0015085
reactant: 098899
kinetic law: 098935
is: GO:0005220
modifier: 098923
name: D3-1
product: 098911
fast: false
reversible: true

098899
type: SpeciesReference
stoichiometry: 1.0
species: 121036

098947
type: LocalParameter
units: metaid_0000223
value: 150.0
name: g

098911
type: SpeciesReference
stoichiometry: 1.0
species: 121026

121485
type: Reaction
kinetic law: 100150
product: 100138
reactant: 100126
is: GO:0030163
fast: false
reversible: false
name: E1-9

100162
type: LocalParameter
units: metaid_0000224
value: 4.63E-5
name: kf

100138
type: SpeciesReference
stoichiometry: 1.0
species: 120964

100126
type: SpeciesReference
stoichiometry: 1.0
species: 120961

121336
type: Reaction
is: GO:0035025
reactant: 097753
reversible: true
reactant: 097765
name: B1-4
is: EBI-876651
fast: false
product: 097777
kinetic law: 097789

097753
type: SpeciesReference
stoichiometry: 1.0
species: 120869

097765
type: SpeciesReference
stoichiometry: 1.0
species: 120889

097777
type: SpeciesReference
stoichiometry: 1.0
species: 120910

097813
type: LocalParameter
units: metaid_0000224
value: 0.5
name: kb

097801
type: LocalParameter
units: metaid_0000223
value: 10.0
name: kf

121549
type: Reaction
is: GO:0004674
product: 101211
reversible: false
reactant: 101199
name: F2-1.2
kinetic law: 101235
is: http://identifiers.org/ec-code/2.7.11.1
fast: false
product: 101223

101211
type: SpeciesReference
stoichiometry: 1.0
species: 121127

101199
type: SpeciesReference
stoichiometry: 1.0
species: 121012

101247
type: LocalParameter
units: metaid_0000224
value: 1.28
name: Vmax

101223
type: SpeciesReference
stoichiometry: 1.0
species: 120869

121660
type: Reaction
is: GO:0032027
kinetic law: 103370
reactant: 103346
name: F2-6.3.1
reactant: 103334
is part of: R03150
fast: false
reversible: true
product: 103358

103406
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

103394
type: LocalParameter
units: dimensionless
value: 1.7299
name: ratio

103382
type: LocalParameter
units: metaid_0000227
value: 10.019
name: Km

103346
type: SpeciesReference
stoichiometry: 1.0
species: 120938

103334
type: SpeciesReference
stoichiometry: 1.0
species: 121127

103358
type: SpeciesReference
stoichiometry: 1.0
species: 121160

121160
type: Species
has part: C00391
has part: P62158
has part: C00076
in compartment: 120775
boundary condition: false
constant: false
initial concentration: 0.0
has only substance units: false
has part: CHEBI:29108
name: MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC
initial amount: NaN
has part: P05976
has part: Q9H1R3

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

121637
type: Reaction
reversible: true
name: F2-5.1.1
fast: false
kinetic law: 102866
product: 102854
is: GO:0032027
is part of: R03150
reactant: 102830
reactant: 102842

102902
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

102890
type: LocalParameter
units: dimensionless
value: 1.7299
name: ratio

102878
type: LocalParameter
units: metaid_0000227
value: 10.019
name: Km

102854
type: SpeciesReference
stoichiometry: 1.0
species: 121181

102830
type: SpeciesReference
stoichiometry: 1.0
species: 121008

102842
type: SpeciesReference
stoichiometry: 1.0
species: 120932

121440
type: Reaction
kinetic law: 099415
product: 099403
reactant: 099391
reactant: 099379
is: GO:0019901
fast: false
reversible: true
name: D1-9

099439
type: LocalParameter
units: metaid_0000224
value: 0.01
name: kb

099427
type: LocalParameter
units: metaid_0000223
value: 10.0
name: kf

099403
type: SpeciesReference
stoichiometry: 1.0
species: 120938

099391
type: SpeciesReference
stoichiometry: 1.0
species: 120928

099379
type: SpeciesReference
stoichiometry: 1.0
species: 120920

121597
type: Reaction
kinetic law: 102100
is: GO:0032027
fast: false
reactant: 102076
name: F2-12.1
product: 102088
reversible: true
reactant: 102064
is: GO:0017018

102136
type: LocalParameter
units: metaid_0000224
value: 1.95
name: Vmax

102124
type: LocalParameter
units: dimensionless
value: 28.795
name: ratio

102112
type: LocalParameter
units: metaid_0000227
value: 58.099
name: Km

102076
type: SpeciesReference
stoichiometry: 1.0
species: 121247

102088
type: SpeciesReference
stoichiometry: 1.0
species: 121139

102064
type: SpeciesReference
stoichiometry: 1.0
species: 121127

121288
type: Reaction
kinetic law: 097041
product: 097028
reactant: 097015
reactant: 097001
is: GO:0016299
fast: false
reversible: true
name: A2-2.1

097079
type: LocalParameter
units: metaid_0000224
value: 0.0102
name: Vmax

097067
type: LocalParameter
units: dimensionless
value: 23.51
name: ratio

097054
type: LocalParameter
units: metaid_0000227
value: 0.05
name: Km

097028
type: SpeciesReference
stoichiometry: 1.0
species: 120841

097015
type: SpeciesReference
stoichiometry: 1.0
species: 120848

097001
type: SpeciesReference
stoichiometry: 1.0
species: 120817

121516
type: Reaction
name: E2-1.2.2
reversible: false
is: http://identifiers.org/ec-code/2.7.11.13
product: 100691
kinetic law: 100703
fast: false
product: 100679
reactant: 100667
is: GO:0004698

100691
type: SpeciesReference
stoichiometry: 1.0
species: 121021

100715
type: LocalParameter
units: metaid_0000224
value: 3.94
name: Vmax

100679
type: SpeciesReference
stoichiometry: 1.0
species: 120958

100667
type: SpeciesReference
stoichiometry: 1.0
species: 120979

121437
type: Reaction
kinetic law: 099343
product: 099331
reactant: 099319
reactant: 099307
is: GO:0019901
fast: false
reversible: true
name: D1-10

099367
type: LocalParameter
units: metaid_0000224
value: 0.01
name: kb

099355
type: LocalParameter
units: metaid_0000223
value: 10.0
name: kf

099331
type: SpeciesReference
stoichiometry: 1.0
species: 120941

099319
type: SpeciesReference
stoichiometry: 1.0
species: 120928

099307
type: SpeciesReference
stoichiometry: 1.0
species: 120923

121653
type: Reaction
reactant: 103166
is: GO:0032027
fast: false
reversible: true
product: 103190
reactant: 103178
kinetic law: 103202
is part of: R03150
name: F2-6.1.1

103166
type: SpeciesReference
stoichiometry: 1.0
species: 121127

103190
type: SpeciesReference
stoichiometry: 1.0
species: 121178

103178
type: SpeciesReference
stoichiometry: 1.0
species: 120932

103238
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

103226
type: LocalParameter
units: dimensionless
value: 1.7299
name: ratio

103214
type: LocalParameter
units: metaid_0000227
value: 10.019
name: Km

121468
type: Reaction
kinetic law: 099898
product: 099886
product: 099874
reactant: 099862
is: GO:0051928
fast: false
reversible: false
name: D2-1.2

099910
type: LocalParameter
units: metaid_0000224
value: 4.9
name: Vmax

099886
type: SpeciesReference
stoichiometry: 1.0
species: 121190

099874
type: SpeciesReference
stoichiometry: 1.0
species: 121058

099862
type: SpeciesReference
stoichiometry: 1.0
species: 121110

121351
type: Reaction
kinetic law: 097994
product: 097981
reactant: 097969
is: GO:0003924
fast: false
reversible: false
name: A1-8

098006
type: LocalParameter
units: metaid_0000224
value: 0.0133
name: kf

097981
type: SpeciesReference
stoichiometry: 1.0
species: 121086

097969
type: SpeciesReference
stoichiometry: 1.0
species: 120848

121400
type: Reaction
kinetic law: 098803
product: 098791
reactant: 098779
is: GO:0032957
fast: false
reversible: false
name: C1-7

098815
type: LocalParameter
units: metaid_0000224
value: 2.5
name: kf

098791
type: SpeciesReference
stoichiometry: 1.0
species: 120825

098779
type: SpeciesReference
stoichiometry: 1.0
species: 120883

121684
type: Reaction
is: R03150
reversible: false
fast: false
product: 103646
name: F2-6.3.2
kinetic law: 103658
product: 103634
is: http://identifiers.org/ec-code/2.7.11.18
is: GO:0004687
reactant: 103622

103646
type: SpeciesReference
stoichiometry: 1.0
species: 120938

103670
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

103634
type: SpeciesReference
stoichiometry: 1.0
species: 121002

103622
type: SpeciesReference
stoichiometry: 1.0
species: 121160

121154
type: Species
name: MYPT1.Rho-kinase
has only substance units: false
has part: Q13464
boundary condition: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
has part: O14974
constant: false

121583
type: Reaction
name: F2-13.2
product: 101859
reactant: 101835
reversible: false
is: http://identifiers.org/ec-code/2.7.11.1
is: GO:0004674
product: 101847
is: GO:0017020
kinetic law: 101871
fast: false

101859
type: SpeciesReference
stoichiometry: 1.0
species: 121247

101835
type: SpeciesReference
stoichiometry: 1.0
species: 121154

101847
type: SpeciesReference
stoichiometry: 1.0
species: 120910

101883
type: LocalParameter
units: metaid_0000224
value: 17.505
name: Vmax

121478
type: Reaction
reversible: true
product: 100018
reactant: 100006
reactant: 099994
kinetic law: 100030
name: E1-7
is: GO:0019992
is part of: GO:0007205
fast: false

100018
type: SpeciesReference
stoichiometry: 1.0
species: 121207

100006
type: SpeciesReference
stoichiometry: 1.0
species: 120876

099994
type: SpeciesReference
stoichiometry: 1.0
species: 121219

100054
type: LocalParameter
units: metaid_0000224
value: 8.6348
name: kb

100042
type: LocalParameter
units: metaid_0000223
value: 0.004
name: kf

121588
type: Reaction
reversible: true
reactant: 101907
name: F2-11.1
is: GO:0017018
is: GO:0032027
kinetic law: 101931
fast: false
reactant: 101895
product: 101919

101907
type: SpeciesReference
stoichiometry: 1.0
species: 121247

101967
type: LocalParameter
units: metaid_0000224
value: 1.95
name: Vmax

101955
type: LocalParameter
units: dimensionless
value: 28.795
name: ratio

101943
type: LocalParameter
units: metaid_0000227
value: 58.099
name: Km

101895
type: SpeciesReference
stoichiometry: 1.0
species: 121002

101919
type: SpeciesReference
stoichiometry: 1.0
species: 121133

120886
type: Species
is: Q9NRY4
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: Rho_GAP

121591
type: Reaction
reactant: 101979
reversible: true
name: F2-9.1
is: GO:0032027
product: 102004
kinetic law: 102016
reactant: 101992
is: GO:0017018
fast: false

101979
type: SpeciesReference
stoichiometry: 1.0
species: 121002

102004
type: SpeciesReference
stoichiometry: 1.0
species: 121136

102052
type: LocalParameter
units: metaid_0000224
value: 9.317
name: Vmax

102040
type: LocalParameter
units: dimensionless
value: 7.5865
name: ratio

102028
type: LocalParameter
units: metaid_0000227
value: 16.0
name: Km

101992
type: SpeciesReference
stoichiometry: 1.0
species: 121243

121322
type: Reaction
kinetic law: 097559
product: 097547
product: 097535
reactant: 097523
is: GO:0035024
fast: false
reversible: false
name: B2-3.2

097571
type: LocalParameter
units: metaid_0000224
value: 0.9933
name: Vmax

097547
type: SpeciesReference
stoichiometry: 1.0
species: 120872

120872
type: Species
initial concentration: 0.1
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: Q9NRY4
in compartment: 120775
is: IPR008936
name: RhoGAP

097535
type: SpeciesReference
stoichiometry: 1.0
species: 120899

097523
type: SpeciesReference
stoichiometry: 1.0
species: 120886

120967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: csa36_degraded

121271
type: Reaction
kinetic law: 096680
product: 096667
reactant: 096655
is: GO:0030163
fast: false
reversible: false
name: A1-5.1

096692
type: LocalParameter
units: metaid_0000224
value: 0.00224
name: kf

096667
type: SpeciesReference
stoichiometry: 1.0
species: 120829

096655
type: SpeciesReference
stoichiometry: 1.0
species: 120834

121285
type: Reaction
kinetic law: 096975
product: 096962
reactant: 096949
reactant: 096936
is: GO:0031684
fast: false
reversible: false
name: A1-7

096988
type: LocalParameter
units: metaid_0000223
value: 0.01
name: kf

096962
type: SpeciesReference
stoichiometry: 1.0
species: 121073

096949
type: SpeciesReference
stoichiometry: 1.0
species: 121077

096936
type: SpeciesReference
stoichiometry: 1.0
species: 121040

ORG:
  orgname: University of Tokyo
n:
  given: Hiroshi
  family: Kobayashi

121543
type: Reaction
kinetic law: 101151
product: 101139
reactant: 101127
reactant: 101115
is: GO:0032027
fast: false
reversible: true
name: F2-2.1

101187
type: LocalParameter
units: metaid_0000224
value: 1.28
name: Vmax

101175
type: LocalParameter
units: dimensionless
value: 16.617
name: ratio

101163
type: LocalParameter
units: metaid_0000227
value: 4.5099
name: Km

101139
type: SpeciesReference
stoichiometry: 1.0
species: 121016

101127
type: SpeciesReference
stoichiometry: 1.0
species: 121127

101115
type: SpeciesReference
stoichiometry: 1.0
species: 120869

121308
type: Reaction
kinetic law: 097415
product: 097403
reactant: 097391
reactant: 097379
is: GO:0035024
fast: false
reversible: true
name: B2-3.1

097451
type: LocalParameter
units: metaid_0000224
value: 0.993
name: Vmax

097439
type: LocalParameter
units: dimensionless
value: 13.246
name: ratio

097427
type: LocalParameter
units: metaid_0000227
value: 2.83
name: Km

097403
type: SpeciesReference
stoichiometry: 1.0
species: 120886

097391
type: SpeciesReference
stoichiometry: 1.0
species: 120889

097379
type: SpeciesReference
stoichiometry: 1.0
species: 120872

121657
type: Reaction
name: F2-6.2.1
product: 103274
is: GO:0032027
reactant: 103262
fast: false
reactant: 103250
is: R03150
kinetic law: 103286
reversible: true

103274
type: SpeciesReference
stoichiometry: 1.0
species: 121172

103262
type: SpeciesReference
stoichiometry: 1.0
species: 120935

103250
type: SpeciesReference
stoichiometry: 1.0
species: 121127

103322
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

103310
type: LocalParameter
units: dimensionless
value: 1.7299
name: ratio

103298
type: LocalParameter
units: metaid_0000227
value: 10.019
name: Km

121573
type: Reaction
reactant: 101607
kinetic law: 101643
reversible: true
reactant: 101619
name: F2-14.1
is: GO:0017020
product: 101631
is: GO:0019901
fast: false

101607
type: SpeciesReference
stoichiometry: 1.0
species: 120869

101679
type: LocalParameter
units: metaid_0000224
value: 1.46
name: Vmax

101667
type: LocalParameter
units: dimensionless
value: 0.23288
name: ratio

101655
type: LocalParameter
units: metaid_0000227
value: 0.18
name: Km

101619
type: SpeciesReference
stoichiometry: 1.0
species: 121243

101631
type: SpeciesReference
stoichiometry: 1.0
species: 121130

121404
type: Reaction
kinetic law: 098863
product: 098851
reactant: 098839
reactant: 098827
is: GO:0005220
fast: false
reversible: true
name: C1-8

098887
type: LocalParameter
units: metaid_0000224
value: 10.0
name: kb

098875
type: LocalParameter
units: metaid_0000228
value: 0.1
name: kf

metaid_0000228
type: SBMLUnitsDef
unit: 096460
unit: 096448
unit: 096436
name: per_uM3_per_sec

096460
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

096448
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

096436
type: SBMLUnit
exponent: -3.0
scale: -6
multipler: 1.0
kind: MOLE

098851
type: SpeciesReference
stoichiometry: 1.0
species: 120862

098839
type: SpeciesReference
stoichiometry: 3.0
species: 120883

098827
type: SpeciesReference
stoichiometry: 1.0
species: 120858

121329
type: Reaction
kinetic law: 097679
product: 097667
product: 097655
reactant: 097643
is: GO:0005089
fast: false
reversible: false
name: B1-2

097691
type: LocalParameter
units: metaid_0000224
value: 0.0117
name: kf

097667
type: SpeciesReference
stoichiometry: 1.0
species: 120866

097655
type: SpeciesReference
stoichiometry: 1.0
species: 121077

097643
type: SpeciesReference
stoichiometry: 1.0
species: 121069

121458
type: Reaction
is: GO:0008426
reactant: 099669
product: 099681
reversible: true
is: GO:0019992
is: GO:0005080
kinetic law: 099693
fast: false
reactant: 099657
name: E1-3

099669
type: SpeciesReference
stoichiometry: 1.0
species: 120876

099681
type: SpeciesReference
stoichiometry: 1.0
species: 120955

099718
type: LocalParameter
units: metaid_0000224
value: 0.1
name: kb

099705
type: LocalParameter
units: metaid_0000223
value: 3.0E-4
name: kf

099657
type: SpeciesReference
stoichiometry: 1.0
species: 120947

121358
type: Reaction
is part of: GO:0007200
kinetic law: 098103
reactant: 098078
fast: false
is: GO:0001965
reversible: true
reactant: 098066
product: 098090
name: C1-2

098127
type: LocalParameter
units: metaid_0000224
value: 1.0
name: kb

098115
type: LocalParameter
units: metaid_0000223
value: 25.201
name: kf

098078
type: SpeciesReference
stoichiometry: 1.0
species: 121237

098066
type: SpeciesReference
stoichiometry: 1.0
species: 120848

098090
type: SpeciesReference
stoichiometry: 1.0
species: 121202

121580
type: Reaction
is: GO:0019901
is: GO:0017049
reactant: 101751
is: GO:0017020
product: 101775
name: F2-13.1
reversible: true
reactant: 101763
kinetic law: 101787
fast: false

101751
type: SpeciesReference
stoichiometry: 1.0
species: 120910

101775
type: SpeciesReference
stoichiometry: 1.0
species: 121154

101763
type: SpeciesReference
stoichiometry: 1.0
species: 121243

101823
type: LocalParameter
units: metaid_0000224
value: 17.505
name: Vmax

101811
type: LocalParameter
units: dimensionless
value: 0.028278
name: ratio

101799
type: LocalParameter
units: metaid_0000227
value: 0.1
name: Km

121614
type: Reaction
reactant: 102433
is: http://identifiers.org/ec-code/3.1.3.53
kinetic law: 102469
fast: false
product: 102445
is: GO:0050115
is: R03151
product: 102457
reversible: false
name: F2-10.2

102433
type: SpeciesReference
stoichiometry: 1.0
species: 121142

102481
type: LocalParameter
units: metaid_0000224
value: 9.317
name: Vmax

102445
type: SpeciesReference
stoichiometry: 1.0
species: 121008

102457
type: SpeciesReference
stoichiometry: 1.0
species: 121243

121488
type: Reaction
kinetic law: 100198
product: 100186
reactant: 100174
is: GO:0030163
fast: false
reversible: false
name: E1-6

100210
type: LocalParameter
units: metaid_0000224
value: 4.63E-5
name: kf

100186
type: SpeciesReference
stoichiometry: 1.0
species: 120967

100174
type: SpeciesReference
stoichiometry: 1.0
species: 120958

121304
type: Reaction
kinetic law: 097331
product: 097319
reactant: 097307
reactant: 097295
is: GO:0005089
fast: false
reversible: true
name: B2-2.1

097367
type: LocalParameter
units: metaid_0000224
value: 0.04
name: Vmax

097355
type: LocalParameter
units: dimensionless
value: 4.0
name: ratio

097343
type: LocalParameter
units: metaid_0000227
value: 2.0
name: Km

097319
type: SpeciesReference
stoichiometry: 1.0
species: 120902

097307
type: SpeciesReference
stoichiometry: 1.0
species: 120899

097295
type: SpeciesReference
stoichiometry: 1.0
species: 120866

121510
type: Reaction
is: GO:0005080
is: GO:0004699
product: 100547
kinetic law: 100559
reversible: true
reactant: 100535
name: E2-1.1.1
is: http://identifiers.org/ec-code/2.7.11.13
fast: false
reactant: 100523

100547
type: SpeciesReference
stoichiometry: 1.0
species: 120976

100595
type: LocalParameter
units: metaid_0000224
value: 3.94
name: Vmax

100583
type: LocalParameter
units: dimensionless
value: 4.0
name: ratio

100571
type: LocalParameter
units: metaid_0000227
value: 0.0014
name: Km

100535
type: SpeciesReference
stoichiometry: 1.0
species: 120997

100523
type: SpeciesReference
stoichiometry: 1.0
species: 120950

121461
type: Reaction
kinetic law: 099754
product: 099742
reactant: 099730
is: GO:0007205
fast: false
reversible: true
name: E1-5

099778
type: LocalParameter
units: metaid_0000224
value: 3.5026
name: kb

099766
type: LocalParameter
units: metaid_0000224
value: 1.2705
name: kf

099742
type: SpeciesReference
stoichiometry: 1.0
species: 120958

099730
type: SpeciesReference
stoichiometry: 1.0
species: 121219

121687
type: Reaction
is: http://identifiers.org/ec-code/2.7.11.18
product: 103706
reactant: 103682
fast: false
kinetic law: 103718
product: 103694
is: GO:0004687
name: F2-5.3.2
reversible: false
is: R03150

103706
type: SpeciesReference
stoichiometry: 1.0
species: 120938

103682
type: SpeciesReference
stoichiometry: 1.0
species: 121166

103730
type: LocalParameter
units: metaid_0000224
value: 3.67
name: Vmax

103694
type: SpeciesReference
stoichiometry: 1.0
species: 121127

121552
type: Reaction
product: 101283
reversible: false
name: F2-2.2
fast: false
product: 101271
is: http://identifiers.org/ec-code/2.7.11.1
reactant: 101259
is: GO:0004674
kinetic law: 101295

101283
type: SpeciesReference
stoichiometry: 1.0
species: 120869

101271
type: SpeciesReference
stoichiometry: 1.0
species: 121002

101259
type: SpeciesReference
stoichiometry: 1.0
species: 121016

101307
type: LocalParameter
units: metaid_0000224
value: 1.28
name: Vmax

W3 CDTF: Sat Sep 30 18:25:23 BST 2006

W3 CDTF: Thu Jul 05 17:29:02 BST 2012