BIOMD0000000084
type: SBMLModel
reaction: metaid_0000015
reaction: metaid_0000013
species: metaid_0000005
created:
  W3 CDTF: Mon Dec 11 10:48:55 GMT 2006
modified:
  W3 CDTF: Mon May 14 13:15:35 BST 2012
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
is: GO:0000165
species: metaid_0000004
reaction: metaid_0000018
is described by: http://identifiers.org/pubmed/15634347
is: GO:0007173
time units: metaid_0000007
name: Hornberg2005_ERKcascade
species: metaid_0000007
reaction: metaid_0000017
species: metaid_0000009
species: metaid_0000011
reaction: metaid_0000019
species: metaid_0000006
species: metaid_0000008
curated: true
notes: SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 Biomodels Curation The model reproduces the time series depicted in Fig 2 of the paper. Also, by varying the values of Vmax for the second kinase (k5) the time series of X3P as shown in Fig3 can be reproduced. The model was successfully tested on MathSBML and Jarnac.
volume units: metaid_0000004
area units: metaid_0000005
is: MODEL6623610941
occurs in: http://identifiers.org/taxonomy/40674
reaction: metaid_0000012
units def: metaid_0000020
reaction: metaid_0000014
compartment: metaid_0000003
has part: rno04010
substance units: metaid_0000020
species: metaid_0000010
length unit: length
reaction: metaid_0000016

metaid_0000015
type: Reaction
kinetic law: 105292
product: 105280
reactant: 105268
is: GO:0051390
fast: false
reversible: true
name: Kinase-1 inactivation

105316
type: LocalParameter
value: 1.0

105304
type: LocalParameter
value: 0.3

105280
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000006
type: Species
is version of: P04049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0
in compartment: metaid_0000003

metaid_0000003
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytosol

105268
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000007
type: Species
is version of: P04049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003

metaid_0000013
type: Reaction
kinetic law: 105159
product: 105147
reactant: 105135
is version of: GO:0045741
fast: false
reversible: true
name: Receptor activation

105183
type: LocalParameter
value: 0.1

105171
type: LocalParameter
value: 0.01

105147
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000004
type: Species
is version of: Q9QX70
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boundary condition: false
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initial concentration: NaN
initial amount: 0.5
in compartment: metaid_0000003

105135
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000005
type: Species
is version of: Q9QX70
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003

metaid_0000018
type: Reaction
name: Kinase-3 activation
kinetic law: 105500
modifier: 105488
is: http://identifiers.org/ec-code/2.7.12.2
is: GO:0004708
fast: false
reactant: 105464
is: GO:0000187
reversible: true
product: 105476

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type: LocalParameter
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type: LocalParameter
value: 1.0

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initial concentration: NaN
initial amount: 0.0
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105464
type: SpeciesReference
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species: metaid_0000010

metaid_0000010
type: Species
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type: SpeciesReference
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metaid_0000011
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initial concentration: NaN
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metaid_0000017
type: Reaction
kinetic law: 105428
product: 105415
reactant: 105403
is: GO:0051389
fast: false
reversible: true
name: Kinase-2 inactivation

105452
type: LocalParameter
value: 1.0

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type: LocalParameter
value: 0.3

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initial amount: 1.0
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105403
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000019
type: Reaction
kinetic law: 105560
product: 105548
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is version of: GO:0043407
fast: false
reversible: true
name: Kinase-3 inactivation

105608
type: LocalParameter
value: 1.0

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type: LocalParameter
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105584
type: LocalParameter
value: 1.0

105572
type: LocalParameter
value: 0.3

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species: metaid_0000010

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000012
type: Reaction
kinetic law: 105099
product: 105087
reactant: 105075
is version of: GO:0007175
fast: false
reversible: true
name: Receptor inactivation

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type: LocalParameter
value: 1.0

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type: SpeciesReference
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species: metaid_0000005

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type: SpeciesReference
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metaid_0000020
type: SBMLUnitsDef
unit: 105063
name: dimensionless

105063
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000014
type: Reaction
kinetic law: 105232
modifier: 105220
product: 105208
reactant: 105195
is: GO:0000185
fast: false
reversible: true
name: Kinase-1 activation

105257
type: LocalParameter
value: 0.1

105244
type: LocalParameter
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105208
type: SpeciesReference
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species: metaid_0000007

105195
type: SpeciesReference
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species: metaid_0000006

metaid_0000016
type: Reaction
modifier: 105354
is: http://identifiers.org/ec-code/2.7.11.1
kinetic law: 105366
fast: false
is: GO:0000186
name: Kinase-2 activation
is: GO:0004709
reversible: true
reactant: 105329
product: 105342

105391
type: LocalParameter
value: 0.1

105379
type: LocalParameter
value: 1.0

105329
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

105342
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009