BIOMD0000000082
type: SBMLModel
is: MODEL1166069080
length unit: length
time units: metaid_0000021
created:
  W3 CDTF: Tue Sep 26 19:47:38 BST 2006
reaction: metaid_0000020
species: metaid_0000005
is described by: http://identifiers.org/pubmed/2904647
compartment: metaid_0000003
species: metaid_0000006
species: metaid_0000015
species: metaid_0000004
reaction: metaid_0000016
species: metaid_0000014
is version of: GO:0007194
species: metaid_0000011
reaction: metaid_0000018
volume units: metaid_0000004
reaction: metaid_0000021
species: metaid_0000010
species: metaid_0000009
curated: true
area units: metaid_0000005
reaction: metaid_0000017
species: metaid_0000008
is version of: GO:0031684
notes: This model was created according to the paper Inhibition of Adenylate Cyclase Is Mediated by the High Affinity Conformation of the alpha2-Adrenergic Receptor published in 1988. The figure4 (steady state curve) in the paper has been simulated having the same plot with Copasi 4.0.19 (development) and roadRunner(online).Because the initial concentration of R and D were not given in the paper ,so we gave it 1e-9 Mol/L and 1e-8 Mol/L respectively. Pay attention that the simulations of steady state concentration of species in arbitrary units are shown for figure4 and figure6 in the paper.
modified:
  W3 CDTF: Fri Apr 20 20:10:29 BST 2012
species: metaid_0000012
substance units: metaid_0100003
reaction: metaid_0000019
creator:
  ORG:
    orgname: University of Oxford
  n:
    given: Enuo
    family: He
occurs in: http://identifiers.org/taxonomy/9606
name: Thomsen1988_AdenylateCyclase_Inhibition

metaid_0000020
type: Reaction
kinetic law: 059037
product: 059025
product: 059013
reactant: 059001
is version of: GO:0043241
fast: false
reversible: false
name: DRG_GTP dissociates(G protein activation)

059049
type: LocalParameter
value: 0.05

059025
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000005
type: Species
constant: false
has part: P18089
initial concentration: 0.0
name: DR
has only substance units: false
has part: P08913
has part: CHEBI:35569
has part: P18825
initial amount: NaN
in compartment: metaid_0000003
boundary condition: false

metaid_0000003
type: Compartment
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

059013
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000014
type: Species
initial amount: NaN
has part: CHEBI:15996
initial concentration: 0.0
boundary condition: false
constant: false
name: G_GTP
has only substance units: false
has part: GO:0005834
in compartment: metaid_0000003

059001
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
boundary condition: false
constant: false
in compartment: metaid_0000003
has only substance units: false
name: DRG_GTP
has part: CHEBI:35569
initial concentration: 0.0
has part: P18089
has part: CHEBI:15996
has part: P18825
initial amount: NaN
has part: P08913
has part: GO:0005834

metaid_0000006
type: Species
in compartment: metaid_0000003
has part: CHEBI:17552
initial concentration: 0.0
has part: GO:0005834
has only substance units: false
has part: P18825
boundary condition: false
initial amount: NaN
constant: false
has part: CHEBI:35569
has part: P18089
name: DRG_GDP
has part: P08913

metaid_0000015
type: Species
boundary condition: false
name: R
initial amount: NaN
in compartment: metaid_0000003
initial concentration: 1.0E-9
constant: false
has version: P08913
has version: P18089
has version: P18825
has only substance units: false

metaid_0000004
type: Species
is version of: CHEBI:35569
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-8
initial amount: NaN
in compartment: metaid_0000003
name: D

metaid_0000016
type: Reaction
kinetic law: 058748
product: 058736
reactant: 058724
reactant: 058712
is version of: GO:0031690
fast: false
reversible: true
name: Forming DR

058772
type: LocalParameter
value: 0.5
name: k7

058760
type: LocalParameter
value: 5000000.0

058736
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

058724
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

058712
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000018
type: Reaction
kinetic law: 058892
product: 058880
product: 058868
reactant: 058856
is version of: GO:0043241
fast: false
reversible: true
name: GDP releasing

058916
type: LocalParameter
value: 100000.0
name: k9

058904
type: LocalParameter
value: 0.1

058880
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000009
type: Species
has part: GO:0005834
initial amount: NaN
has part: P08913
has only substance units: false
constant: false
has part: CHEBI:35569
has part: P18089
initial concentration: 0.0
has part: P18825
boundary condition: false
name: DRG
in compartment: metaid_0000003

058868
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000010
type: Species
is: CHEBI:17552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: GDP

058856
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000021
type: Reaction
kinetic law: 059085
product: 059073
reactant: 059061
is version of: GO:0003924
fast: false
reversible: false
name: G protein inactivated

059097
type: LocalParameter
value: 0.1

059073
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
name: G_GDP
in compartment: metaid_0000003
has part: CHEBI:17552
has part: GO:0005834
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0E-9

059061
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000017
type: Reaction
kinetic law: 058820
product: 058808
reactant: 058796
reactant: 058784
is version of: GO:0001664
fast: false
reversible: true
name: DR binding with G_GDP produc DRG_GDP

058844
type: LocalParameter
value: 0.1
name: k8

058832
type: LocalParameter
value: 1.0E8

058808
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

058796
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

058784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000012
type: Species
is: CHEBI:15996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-5
initial amount: NaN
in compartment: metaid_0000003
name: GTP

metaid_0000019
type: Reaction
name: GTP binding with DRG
is version of: GO:0005525
fast: false
reactant: 058940
kinetic law: 058964
reversible: true
product: 058952
reactant: 058928
is version of: GO:0032403

058940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

058988
type: LocalParameter
value: 0.1
name: k10

058976
type: LocalParameter
value: 1.0E7

058952
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

058928
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009