BIOMD0000000080
type: SBMLModel
reaction: metaid_0000017
species: metaid_0000005
reaction: metaid_0000019
species: metaid_0000006
created:
  W3 CDTF: Wed Sep 27 11:07:57 BST 2006
curated: true
is version of: GO:0007194
reaction: metaid_0000014
creator:
  ORG:
    orgname: University of Oxford
  n:
    given: Enuo
    family: He
species: metaid_0000007
is: MODEL1173806337
notes: This model reproduces figure 5 and figure 4(B)of the paper, with Kinh represented by [G-GTP]. We arbitrarily chosed to set the initial concentration of D to 31 micorMolar based on legend of figure 4. [R] was not given anywhere in the paper and was chosen to calibrate the sigmoid response to an increased [GTP]. THe figure 5 in the model was successfully simulated on COPASI 4.0 ,the figure 4(B) was sucessfully simulated on both COPASI and SBML_odeSolver. There are two curves for Kinh in the absence and presence of NaCl in the figure obtained from simulations of the model using parameters of set C and set D.Here in the model the initial value given is from set D.The parameters in set C :k7=0.5, k10=1.0,k5=0.1,the others are the same with set D.
reaction: metaid_0000016
species: metaid_0000011
area units: metaid_0000005
compartment: metaid_0000003
name: Thomsen1989_AdenylateCyclase
species: metaid_0000012
length unit: length
occurs in: http://identifiers.org/taxonomy/9606
time units: metaid_0000021
reaction: metaid_0000015
reaction: metaid_0000018
species: metaid_0000013
is described by: http://identifiers.org/pubmed/2574993
is version of: GO:0031684
species: metaid_0000008
volume units: metaid_0000004
species: metaid_0000009
species: metaid_0000004
substance units: metaid_0000022
species: metaid_0000010
modified:
  W3 CDTF: Fri Apr 20 20:09:08 BST 2012

metaid_0000017
type: Reaction
fast: false
reversible: true
reactant: 030434
name: GTP binding with DRG
product: 030446
is version of: GO:0032403
is version of: GO:0005525
reactant: 030422
kinetic law: 030458

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metaid_0000011
type: Species
is: CHEBI:15996
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boundary condition: false
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initial concentration: 1.0E-5
initial amount: NaN
in compartment: metaid_0000003
name: GTP

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is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

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name: DRG_GTP
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is version of: GO:0003924
fast: false
reversible: false
name: Hydrolysis of GTP to GDP

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type: LocalParameter
value: 2.0

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initial amount: NaN
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boundary condition: false
constant: false
name: G_GDP

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name: G_GTP
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type: Reaction
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reactant: 030205
is version of: GO:0031690
fast: false
reversible: true
name: Forming DR

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constant: false
has version: P18089
has version: P18825
boundary condition: false
in compartment: metaid_0000003
initial concentration: 1.0E-10
initial amount: NaN
name: R
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type: Species
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name: D

metaid_0000016
type: Reaction
kinetic law: 030386
product: 030374
product: 030362
reactant: 030350
is version of: GO:0043241
fast: false
reversible: true
name: GDP Releasing

030410
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value: 100000.0

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value: 5.0

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name: GDP

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type: Reaction
kinetic law: 030314
product: 030302
reactant: 030289
reactant: 030277
is version of: GO:0001664
fast: false
reversible: true
name: DR Binding with G_GDP produce DRG_GDP

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type: LocalParameter
value: 1.0E8

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type: Reaction
kinetic law: 030530
product: 030518
product: 030506
reactant: 030494
is version of: GO:0043241
fast: false
reversible: false
name: G protein activation

030542
type: LocalParameter
value: 1.0

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type: SpeciesReference
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species: metaid_0000005

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

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type: SpeciesReference
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species: metaid_0000010