BIOMD0000000077
type: SBMLModel
species: metaid_0000020
rule: metaid_0000021
modified:
  W3 CDTF: Fri Apr 20 20:03:22 BST 2012
units def: metaid_0000005
event: metaid_0000019
reaction: metaid_0000014
species: metaid_0000007
reaction: metaid_0000015
species: metaid_0000011
is described by: http://identifiers.org/pubmed/10662710
species: metaid_0000008
area units: metaid_0000005
volume units: metaid_0000004
species: metaid_0000012
notes: A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000) This paper includes three stages, and the model does not include the third stage. Also an event is included which remove the hormone GnRH at time=5min. Figure 1 and Figure 2 of the paper are reproduced, using SBML odeSolver. We choose to encode the model with the concentration of GnRH equal to 1.0nM. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
is: MODEL3092061764
created:
  W3 CDTF: Thu Nov 09 17:07:08 GMT 2006
is part of: GO:0007200
substance units: metaid_0000005
time units: metaid_0000004
reaction: metaid_0000018
parameter: metaid_0000022
species: metaid_0000010
compartment: metaid_0000006
units def: metaid_0000004
units def: metaid_0000024
curated: true
length unit: length
occurs in: http://identifiers.org/taxonomy/131567
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Enuo
    family: He
is part of: GO:0032275
parameter: metaid_0000023
species: metaid_0000009
reaction: metaid_0000017
species: metaid_0000013
reaction: metaid_0000016
name: Blum2000_LHsecretion_1

metaid_0000020
type: Species
is version of: IPR000699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: CHO

metaid_0000006
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

982701
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000019
type: Event
event assignment: 982929
trigger: 982917
is version of: GO:0046888
use values from trigger time: true
name: removal of hormone

metaid_0000007
type: Species
initial amount: NaN
boundary condition: false
has version: P51924
has only substance units: false
in compartment: metaid_0000006
has version: P07490
initial concentration: 1.0
name: H
constant: false

982917
type: Trigger
persistant: true
initial value: true

metaid_0000014
type: Reaction
is version of: GO:0051428
fast: false
product: 982749
reversible: true
is version of: GO:0004968
kinetic law: 982761
reactant: 982725
reactant: 982737
is version of: GO:0005102
name: H binding to R

982749
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
has only substance units: false
in compartment: metaid_0000006
initial concentration: 0.0
initial amount: NaN
boundary condition: false
constant: false
name: HR
has version: P30969
has version: P07490

367356
type: LocalParameter
value: 5.0

367354
type: LocalParameter
value: 2.5

982725
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

982737
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000009
type: Species
has version: P30969
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.01
initial amount: NaN
in compartment: metaid_0000006
name: R

metaid_0000015
type: Reaction
kinetic law: 982797
product: 982785
reactant: 982773
is version of: GO:0006461
fast: false
reversible: true
name: HR forming HRRH

367358
type: LocalParameter
value: 5.0

367357
type: LocalParameter
value: 2500.0

982785
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000010
type: Species
is version of: GO:0043234
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: HRRH

982773
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000008

metaid_0000011
type: Species
is: PIRSF005483
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: E

metaid_0000012
type: Species
has version: GO:0005834
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000006
name: GQ

982689
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000018
type: Reaction
kinetic law: 982905
modifier: 982893
product: 982881
is version of: GO:0004629
fast: false
reversible: false
name: Production of IP3

367362
type: LocalParameter
value: 2.0E7

982881
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000013
type: Species
constant: false
boundary condition: false
is version of: CHEBI:16595
is version of: C01245
initial amount: NaN
has only substance units: false
in compartment: metaid_0000006
name: IP3
initial concentration: 0.0

metaid_0000022
type: Parameter
constant: true
units: metaid_0000005
value: 2.0
name: alpha

metaid_0000024
type: SBMLUnitsDef
unit: 982713
name: unit for beta

982713
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000023
type: Parameter
constant: true
units: metaid_0000024
value: 4.0
name: beta

metaid_0000017
type: Reaction
kinetic law: 982869
reactant: 982857
is version of: GO:0009056
fast: false
reversible: false
name: IP3 converted into inactive metabolites

367361
type: LocalParameter
value: 10.0

982857
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000016
type: Reaction
kinetic law: 982845
product: 982833
reactant: 982821
reactant: 982809
is version of: GO:0007202
fast: false
reversible: true
name: G protein react with dimer producing E

367360
type: LocalParameter
value: 200.0

367359
type: LocalParameter
value: 4000.0

982833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

982821
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

982809
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010