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type: SBMLModel
compartment: metaid_0000003
units def: metaid_0000035
parameter: metaid_0000074
units def: metaid_0000038
parameter: metaid_0000051
species: metaid_0000076
reaction: metaid_0000024
species: metaid_0000013
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rule: metaid_0011071
is described by: http://identifiers.org/pubmed/11415442
rule: metaid_0000071
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notes: . . . SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 . . Biomodels Curation: The paper refers to the model equations present in Bakker et al's " Glycolysis in bloodstream from Trypanosoma brucei can be understood in terms of the kinetics of glycolytic enzymes" (Pubmed ID: 9013556), also, the authors claim that some of the modifications in these equations were made based on the experimental results from the paper "Contribution of glucose transport in the control of glycolytic flux in Trypanosoma brucei" (Pubmed ID: 10468568). The model reproduces the various flux values in Fig 3 for 100% TPI activity. It also matches with the values provided in Table 2 of the paper. The model was successfully tested with Copasi and SBML ODE Solver. The volumes are set to the values containing 1 mg of total protein per microlitre total cell volume. To change the protein concentration use Vt , the total cell volume in micro litre per mg protein. To change the TPI activity use the global parameter TPIact . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol.…
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852467
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852461
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852457
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metaid_0000072
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metaid_0000060
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502967
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852452
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852446
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852437
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852436
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metaid_0000036
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value: 5.1

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value: 0.12

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value: 0.19

852481
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value: 33400.0

852480
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value: 1.0

metaid_0011035
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name: microlitre

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kind: LITRE

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is homolog to: REACT 2092
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value: 0.75

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852371
type: LocalParameter
units: metaid_0000037
value: 106.2

502547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

metaid_0000004
type: Species
is version of: CHEBI:17234
name: Glucose
boundary condition: false
in compartment: metaid_0010003
has only substance units: false
initial amount: NaN
is version of: C00293
constant: false
initial concentration: 0.0340009

502535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000022
type: Reaction
modifier: 502619
reactant: 502571
is homolog to: REACT 1318
reactant: 502583
reversible: false
name: Hexokinase
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: 502631
is: R00299
fast: false
modifier: 502607
product: 502595

502571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

502583
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000004

852386
type: LocalParameter
units: metaid_0000039
value: 0.126

852383
type: LocalParameter
units: metaid_0000039
value: 12.0

852380
type: LocalParameter
units: metaid_0000039
value: 0.1

852377
type: LocalParameter
units: metaid_0000039
value: 0.116

852376
type: LocalParameter
units: metaid_0000037
value: 625.0

502595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000053
type: Parameter
constant: true
units: dimensionless
value: 1.0

metaid_0000055
type: Parameter
constant: true
units: metaid_0000039
value: 5.0

W3 CDTF: Thu Oct 09 20:54:12 BST 2008

ORG:
  orgname: Stellenbosh University
n:
  given: Jacky L
  family: Snoep

ORG:
  orgname: EBI/EMBL
n:
  given: Lukas
  family: Endler

W3 CDTF: Thu Jul 05 15:38:34 BST 2012

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri