BIOMD0000000059
type: SBMLModel
parameter: metaid_0000054
compartment: metaid_0000175
reaction: metaid_0000145
rule: metaid_0000101
parameter: metaid_0000038
parameter: metaid_0000018
parameter: metaid_0000068
rule: metaid_0000128
rule: metaid_0000097
parameter: metaid_0000154
parameter: metaid_0000185
parameter: metaid_0000085
parameter: metaid_0000182
rule: metaid_0000156
reaction: metaid_0000141
parameter: metaid_0000031
rule: metaid_0000110
parameter: metaid_0000084
parameter: metaid_0000033
parameter: metaid_0000064
parameter: metaid_0000081
parameter: metaid_0000061
units def: metaid_0000164
rule: metaid_0000129
parameter: metaid_0000049
parameter: metaid_0000012
species: metaid_0000092
parameter: metaid_0000077
units def: metaid_0000168
parameter: metaid_0000179
has part: GO:0050848
reaction: metaid_0000133
reaction: metaid_0000150
parameter: metaid_0000026
parameter: metaid_0000056
parameter: metaid_0000025
parameter: metaid_0000006
rule: metaid_0000119
rule: metaid_0000106
parameter: metaid_0000059
parameter: metaid_0000058
units def: metaid_0000171
parameter: metaid_0000073
time units: metaid_0000160
rule: metaid_0000122
reaction: metaid_0000147
reaction: metaid_0000146
parameter: metaid_0000021
parameter: metaid_0000052
parameter: metaid_0000087
units def: metaid_0000159
has part: GO:0050796
rule: metaid_0000107
parameter: metaid_0000035
substance units: metaid_0000159
parameter: metaid_0000083
reaction: metaid_0000142
units def: metaid_0000162
rule: metaid_0000131
parameter: metaid_0000065
rule: metaid_0000123
compartment: metaid_0000088
species: metaid_0000094
parameter: metaid_0000013
units def: metaid_0000166
parameter: metaid_0000079
parameter: metaid_0000029
rule: metaid_0000104
rule: metaid_0000117
parameter: metaid_0000046
units def: metaid_0000169
parameter: metaid_0000028
reaction: metaid_0000152
parameter: metaid_0000008
parameter: metaid_0000042
parameter: metaid_0000177
reaction: metaid_0000134
rule: metaid_0000120
parameter: metaid_0000075

metaid_0000054
type: Parameter
constant: true
units: metaid_0000161
value: 7.0

metaid_0000161
type: SBMLUnitsDef
unit: 326181
name: Voltage

326181
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT

metaid_0000175
type: Compartment
is: GO:0005783
constant: true
size: 2.8E-13
spatial dimensions: 3.0
name: endoplasmic reticulum

metaid_0000145
type: Reaction
kinetic law: 326831
product: 326819
is version of: GO:0005248
fast: false
reversible: false

326819
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000094
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 9858.0
in compartment: metaid_0000088
boundary condition: false
is: CHEBI:29101
constant: false
is: C01330
name: Cytosolic Sodium

metaid_0000088
type: Compartment
is: GO:0005737
constant: true
size: 7.64E-13
spatial dimensions: 3.0
name: cytoplasm

metaid_0000038
type: Parameter
constant: false
value: 0.0

metaid_0000018
type: Parameter
constant: true
units: metaid_0000163
value: 200.0

metaid_0000163
type: SBMLUnitsDef
unit: 326217
unit: 326205
name: Concentration

326217
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

326205
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000068
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000162
type: SBMLUnitsDef
unit: 326193
name: Current

326193
type: SBMLUnit
exponent: 1.0
scale: -15
multipler: 1.0
kind: AMPERE

metaid_0000154
type: Parameter
constant: false
units: metaid_0000161
value: -60.9

metaid_0000185
type: Parameter
constant: true
units: metaid_0000166
value: 5.0E-5
name: Rate constant of ATP consumption

metaid_0000166
type: SBMLUnitsDef
unit: 326253
name: Time inverse

326253
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

metaid_0000085
type: Parameter
constant: false
units: metaid_1000168
value: 0.0

metaid_1000168
type: SBMLUnitsDef
unit: 326301
unit: 326289
name: amount per time

326301
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326289
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000182
type: Parameter
constant: true
units: metaid_0000166
value: 4.0E-5
name: IP3 degradation rate constant

metaid_0000141
type: Reaction
kinetic law: 326735
modifier: 326723
product: 326710
is: GO:0004435
is: http://identifiers.org/ec-code/3.1.4.11
fast: false
reversible: false

metaid_0000091
type: Species
name: Cytosolic Calcium
is: CHEBI:29108
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.085
initial amount: NaN
in compartment: metaid_0000088
is: C00076

326710
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000093
type: Species
in compartment: metaid_0000088
constant: false
initial concentration: 0.33
initial amount: NaN
has only substance units: false
boundary condition: false
is: C01245
name: Cytosolic IP3
is: CHEBI:16595

metaid_0000031
type: Parameter
constant: false
value: 0.0

metaid_0000084
type: Parameter
constant: true
units: metaid_0000163
value: 3.2

metaid_0000033
type: Parameter
constant: false
value: 0.0

metaid_0000064
type: Parameter
constant: true
units: metaid_0000163
value: 0.1

metaid_0000081
type: Parameter
constant: true
units: metaid_0000163
value: 0.5

metaid_0000061
type: Parameter
constant: true
units: metaid_0000164
value: 770.0

metaid_0000164
type: SBMLUnitsDef
unit: 326229
name: Conductance

326229
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: SIEMENS

metaid_0000049
type: Parameter
constant: true
units: metaid_0000163
value: 17.0

metaid_0000012
type: Parameter
constant: false
units: metaid_0000161
value: 0.0

metaid_0000092
type: Species
in compartment: metaid_0000175
constant: false
has only substance units: false
initial amount: NaN
name: ER Calcium
is: C00076
is: CHEBI:29108
boundary condition: false
initial concentration: 22.8

metaid_0000077
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000168
type: SBMLUnitsDef
unit: 326337
unit: 326325
unit: 326313
name: concentration per time

326337
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

326325
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326313
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000179
type: Parameter
constant: true
units: dimensionless
value: 0.03

metaid_0000133
type: Reaction
kinetic law: 326554
product: 326542
is version of: GO:0005245
fast: false
reversible: false

326542
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000150
type: Reaction
kinetic law: 326963
reactant: 326951
is: GO:0005388
is: http://identifiers.org/ec-code/3.6.3.8
fast: false
reversible: false

326951
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000095
type: Species
boundary condition: false
is: C00002
initial amount: NaN
name: Cytosolic ATP
in compartment: metaid_0000088
has only substance units: false
constant: false
initial concentration: 932.1
is: CHEBI:15422

metaid_0000026
type: Parameter
constant: false
value: 0.0

metaid_0000056
type: Parameter
constant: true
units: metaid_0000160
value: 20.0

metaid_0000160
type: SBMLUnitsDef
unit: 326169
name: milliseconds

326169
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

metaid_0000025
type: Parameter
constant: true
units: metaid_0000166
value: 0.03

metaid_0000006
type: Parameter
constant: true
units: metaid_0000163
value: 2600.0

metaid_0000059
type: Parameter
constant: true
units: metaid_0000161
value: 20.0

metaid_0000058
type: Parameter
constant: true
units: metaid_0000161
value: 65.0

metaid_0000171
type: SBMLUnitsDef
unit: 326433
unit: 326421
unit: 326409
name: per concentration cubed per time

326433
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

326421
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326409
type: SBMLUnit
exponent: -3.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000073
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000147
type: Reaction
kinetic law: 326891
modifier: 326879
product: 326867
is: GO:0006754
fast: false
reversible: false

metaid_0000158
type: Species
is: C00008
name: Cytosolic ADP
has only substance units: false
boundary condition: false
initial concentration: 3067.9
in compartment: metaid_0000088
is: CHEBI:16761
constant: false
initial amount: NaN

326867
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000146
type: Reaction
kinetic law: 326855
product: 326843
is version of: GO:0005227
fast: false
reversible: false

326843
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000021
type: Parameter
constant: false
units: dimensionless
value: 0.0

metaid_0000052
type: Parameter
constant: false
units: dimensionless
value: 0.0

metaid_0000087
type: Parameter
constant: true
units: metaid_0000169
value: 1.2E-15

metaid_0000169
type: SBMLUnitsDef
unit: 326361
unit: 326349
name: volume per time

326361
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326349
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

metaid_0000159
type: SBMLUnitsDef
unit: 326157
name: Micromole

326157
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000035
type: Parameter
constant: false
value: 0.0

metaid_0000083
type: Parameter
constant: true
units: metaid_0000163
value: 0.077

metaid_0000142
type: Reaction
kinetic law: 326759
reactant: 326747
fast: false
reversible: false

326747
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000065
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000013
type: Parameter
constant: false
value: 0.0

metaid_0000079
type: Parameter
constant: false
units: metaid_0000168
value: 0.0

metaid_0000029
type: Parameter
constant: true
units: metaid_0000172
value: 1.5E-8

metaid_0000172
type: SBMLUnitsDef
unit: 326469
unit: 326457
unit: 326445
name: per Concentration square per time

326469
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE

326457
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326445
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000046
type: Parameter
constant: false
units: dimensionless
value: 0.0

metaid_0000028
type: Parameter
constant: false
value: 0.0

metaid_0000152
type: Reaction
kinetic law: 327023
reactant: 327011
is: GO:0006200
fast: false
reversible: false

327011
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000008
type: Parameter
constant: true
units: metaid_0000163
value: 8000.0

metaid_0000042
type: Parameter
constant: true
units: metaid_0000166
value: 10.0

metaid_0000177
type: Parameter
constant: true
units: metaid_0000174
value: 9.6485E16
name: Faraday's constant

metaid_0000174
type: SBMLUnitsDef
unit: 326530
unit: 326518
unit: 326506
name: Faraday constant

326530
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

326518
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

326506
type: SBMLUnit
exponent: 1.0
scale: -15
multipler: 1.0
kind: AMPERE

metaid_0000134
type: Reaction
kinetic law: 326578
product: 326566
is version of: GO:0005432
fast: false
reversible: false

326566
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000075
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000072
type: Parameter
constant: true
units: metaid_0000162
value: 600.0

metaid_0000149
type: Reaction
kinetic law: 326939
reactant: 326927
is: GO:0005388
is: http://identifiers.org/ec-code/3.6.3.8
fast: false
reversible: false

326927
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000023
type: Parameter
constant: true
units: metaid_0000170
value: 0.002

metaid_0000170
type: SBMLUnitsDef
unit: 326397
unit: 326385
unit: 326373
name: per concentration per time

326397
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

326385
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

326373
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000071
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000053
type: Parameter
constant: true
units: metaid_0000161
value: -14.0

metaid_0000144
type: Reaction
kinetic law: 326807
reactant: 326795
is: GO:0005391
is: http://identifiers.org/ec-code/3.6.3.9
fast: false
reversible: false

326795
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000037
type: Parameter
constant: true
units: metaid_0000163
value: 4950.0

metaid_0000067
type: Parameter
constant: true
units: metaid_0000163
value: 0.75

metaid_0000017
type: Parameter
constant: true
units: metaid_0000167
value: 0.7

metaid_0000167
type: SBMLUnitsDef
unit: 326277
unit: 326265
name: Conductance coefficient

326277
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

326265
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: SIEMENS

metaid_0000069
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000184
type: Parameter
constant: true
units: metaid_0000170
value: 5.0E-5
name: Ca dependent ATP consumption

metaid_0000181
type: Parameter
constant: true
units: metaid_0000163
value: 0.4
name: half activation cytosolic Ca

metaid_0000016
type: Parameter
constant: false
value: 0.0

metaid_0000030
type: Parameter
constant: false
value: 0.0

metaid_0000063
type: Parameter
constant: true
units: metaid_0000162
value: 2000.0

metaid_0000180
type: Parameter
constant: true
units: metaid_0000168
value: 3.0E-4
name: IP3 production rate constant

metaid_0000080
type: Parameter
constant: false
units: metaid_0000168
value: 0.105

metaid_0000060
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000044
type: Parameter
constant: true
units: metaid_0000166
value: 11.5

metaid_0000137
type: Reaction
kinetic law: 326674
product: 326662
reactant: 326650
has part: GO:0005220
has part: GO:0007204
fast: false
reversible: false

326662
type: SpeciesReference
stoichiometry: 0.01
species: metaid_0000091

326650
type: SpeciesReference
stoichiometry: 0.03
species: metaid_0000092

metaid_0000011
type: Parameter
constant: true
units: metaid_0000163
value: 140000.0

metaid_0000009
type: Parameter
constant: true
units: metaid_0000163
value: 132400.0

metaid_0000178
type: Parameter
constant: true
units: metaid_0000166
value: 1.0E-4

metaid_0000040
type: Parameter
constant: true
units: metaid_0000163
value: 150400.0

metaid_0000055
type: Parameter
constant: false
units: metaid_0000160
value: 0.0

metaid_0000005
type: Parameter
constant: true
units: metaid_0000161
value: 26.73

metaid_0000057
type: Parameter
constant: true
units: metaid_0000161
value: -75.0

metaid_0000173
type: SBMLUnitsDef
unit: 326494
unit: 326481
name: per concentration

326494
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

326481
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000004
type: Parameter
constant: false
units: metaid_0000161
value: 0.0

metaid_0000039
type: Parameter
constant: true
units: metaid_0000170
value: 6.0E-7

metaid_0000019
type: Parameter
constant: false
units: metaid_0000161
value: 0.0

metaid_0000153
type: Parameter
constant: false
value: 0.00123

metaid_0000155
type: Parameter
constant: true
units: metaid_0000165
value: 6158.0

metaid_0000165
type: SBMLUnitsDef
unit: 326241
name: Capacitance

326241
type: SBMLUnit
exponent: 1.0
scale: -15
multipler: 1.0
kind: FARAD

metaid_0000051
type: Parameter
constant: true
units: metaid_0000163
value: 1.0

metaid_0000086
type: Parameter
constant: true
units: metaid_0000169
value: 1.0E-16

metaid_0000032
type: Parameter
constant: true
units: metaid_0000170
value: 1.0E-4

metaid_0000034
type: Parameter
constant: true
units: metaid_0000171
value: 1.72E-17

metaid_0000082
type: Parameter
constant: false
units: dimensionless
value: 0.0

W3 CDTF: Thu Jul 05 17:49:00 BST 2012

metaid_0000138
type: Reaction
kinetic law: 326698
reactant: 326686
is: GO:0051208
fast: false
reversible: false

326686
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000078
type: Parameter
constant: true
units: metaid_0000164
value: 24000.0

metaid_0000045
type: Parameter
constant: true
units: metaid_0000166
value: 100.0

W3 CDTF: Tue Jun 20 14:12:19 BST 2006

metaid_0000027
type: Parameter
constant: true
units: metaid_0000171
value: 2.5E-10

metaid_0000151
type: Reaction
kinetic law: 326999
modifier: 326987
reactant: 326975
is: GO:0030899
fast: false
reversible: false

326975
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000007
type: Parameter
constant: false
units: metaid_0000161
value: 0.0

metaid_0000176
type: Parameter
constant: true
units: dimensionless
value: 0.01

metaid_0000041
type: Parameter
constant: false
value: 0.0

metaid_0000074
type: Parameter
constant: true
units: metaid_0000164
value: 3000.0

metaid_0000020
type: Parameter
constant: true
units: metaid_0000161
value: 0.0

metaid_0000148
type: Reaction
kinetic law: 326915
reactant: 326903
is: GO:0005391
is: http://identifiers.org/ec-code/3.6.3.9
fast: false
reversible: false

326903
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000022
type: Parameter
constant: false
value: 0.0

metaid_0000070
type: Parameter
constant: true
units: metaid_0000164
value: 1200.0

metaid_0000050
type: Parameter
constant: true
units: metaid_0000163
value: 26.0

metaid_0000036
type: Parameter
constant: true
units: metaid_0000170
value: 2.0E-4

metaid_0000143
type: Reaction
kinetic law: 326783
reactant: 326771
is: GO:0005432
fast: false
reversible: false

326771
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000066
type: Parameter
constant: true
units: metaid_0000164
value: 271.0

metaid_0000183
type: Parameter
constant: true
units: metaid_0000166
value: 3.7E-4
name: ATP production rate constant

metaid_0000015
type: Parameter
constant: true
units: metaid_0000161
value: 9.5

metaid_0000014
type: Parameter
constant: true
units: metaid_0000161
value: -19.0

metaid_0000048
type: Parameter
constant: false
units: dimensionless
value: 0.0

metaid_0000047
type: Parameter
constant: true
units: metaid_0000163
value: 0.1

metaid_0000062
type: Parameter
constant: false
units: metaid_0000162
value: 0.0

metaid_0000043
type: Parameter
constant: true
units: metaid_0000166
value: 0.172

metaid_0000136
type: Reaction
has part: GO:0005388
reversible: false
product: 326626
has part: GO:0005524
is: http://identifiers.org/ec-code/3.6.3.8
reactant: 326614
kinetic law: 326638
fast: false

326626
type: SpeciesReference
stoichiometry: 0.03
species: metaid_0000092

326614
type: SpeciesReference
stoichiometry: 0.01
species: metaid_0000091

metaid_0000135
type: Reaction
kinetic law: 326602
reactant: 326590
has part: GO:0005524
has part: GO:0005388
is: http://identifiers.org/ec-code/3.6.3.8
fast: false
reversible: false

326590
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000010
type: Parameter
constant: false
units: metaid_0000161
value: 0.0

metaid_0000076
type: Parameter
constant: true
units: metaid_0000164
value: 130.0

metaid_0000024
type: Parameter
constant: false
value: 0.0

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri