BIOMD0000000058
type: SBMLModel
reaction: metaid_0000040
created:
  W3 CDTF: Wed May 31 09:28:41 BST 2006
has part: GO:0048016
parameter: metaid_0000005
species: metaid_0000021
reaction: metaid_0000033
compartment: metaid_0000019
notes: The model reproduces the same amplitude antiphase calcium oscillations of coupled cells depicted in Figure 5B of the publication. This model was successfully tested on Jarnac and MathSBML. The values of "h1" and "h2" are not given in the publication, but the antiphase oscillations are reproduced over a narrow range of values of h1, h2,c1,c2,D and p. The values of D and p are given, while the other values were plugged in, in order to simulate the time profiles shown in the Figure. The time t=0 in the figure may have been fixed after the system was allowed to settle, and hence does not correspond to the t=0 of the simulation. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
rule: metaid_0000028
reaction: metaid_0000039
reaction: metaid_0000043
parameter: metaid_0000012
volume units: metaid_0000323
modified:
  W3 CDTF: Thu Jun 06 12:40:36 BST 2013
area units: area
time units: metaid_0000366
name: Bindschadler2001_coupled_Ca_oscillators
parameter: metaid_0000015
curated: true
species: metaid_0000024
is described by: http://identifiers.org/pubmed/12779457
parameter: metaid_0000006
rule: metaid_0000026
reaction: metaid_0000034
rule: metaid_0000027
occurs in: http://identifiers.org/taxonomy/131567
is: map04020
is: MODEL9107330008
has part: GO:0019722
parameter: metaid_0000009
reaction: metaid_0000037
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
reaction: metaid_0000041
parameter: metaid_0000010
parameter: metaid_0000016
units def: metaid_0000044
rule: metaid_0000031
rule: metaid_0000032
substance units: metaid_0000044
parameter: metaid_0000003
parameter: metaid_0000013
length unit: length
parameter: metaid_0000007
parameter: metaid_0000017
species: metaid_0000023
rule: metaid_0000025
reaction: metaid_0000035
species: metaid_0000022
reaction: metaid_0000038
reaction: metaid_0000042
parameter: metaid_0000011
rule: metaid_0000030
rule: metaid_0000029
parameter: metaid_0000004
parameter: metaid_0000014
parameter: metaid_0000008
parameter: metaid_0000018
reaction: metaid_0000036

metaid_0000040
type: Reaction
kinetic law: 915833
product: 915821
is version of: GO:0051209
is version of: GO:0007204
fast: false
reversible: false
name: IP3R independent Ca release Cell2

915845
type: LocalParameter
value: 0.2

915821
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000023
type: Species
has only substance units: false
initial amount: NaN
name: Calcium ion Cell2
in compartment: metaid_0000019
boundary condition: false
initial concentration: 0.1
constant: false
is: C00076
is: CHEBI:29108

metaid_0000019
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000005
type: Parameter
constant: true
value: 6.0

metaid_0000021
type: Species
initial amount: NaN
in compartment: metaid_0000019
name: Calcium ion Cell1
boundary condition: false
is: C00076
is: CHEBI:29108
constant: false
has only substance units: false
initial concentration: 0.3

metaid_0000033
type: Reaction
kinetic law: 915532
modifier: 915520
product: 915508
is version of: GO:0007204
is: GO:0005220
fast: false
reversible: false
name: IP3R mediated Ca release Cell1

915556
type: LocalParameter
value: 0.2778

915544
type: LocalParameter
value: 28.0

metaid_0000022
type: Species
is version of: IPR000493
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.8
initial amount: NaN
in compartment: metaid_0000019
name: Receptor fraction Cell1

915508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000039
type: Reaction
kinetic law: 915785
reactant: 915773
is: GO:0005388
fast: false
reversible: false
name: ATPase pump mediated Ca efflux Cell2

915809
type: LocalParameter
value: 0.18

915797
type: LocalParameter
value: 1.2

915773
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000043
type: Reaction
kinetic law: 915941
product: 915929
reactant: 915917
is version of: GO:0015085
fast: false
reversible: false
name: Diffusion of Ca between cells

915954
type: LocalParameter
value: 0.01

915929
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

915917
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000012
type: Parameter
constant: false
value: 0.0

metaid_0000015
type: Parameter
constant: false
value: 0.0

metaid_0000024
type: Species
is version of: IPR000493
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000019
name: Receptor fraction Cell2

metaid_0000006
type: Parameter
constant: false
value: 0.0

metaid_0000034
type: Reaction
kinetic law: 915581
reactant: 915568
is: GO:0005388
fast: false
reversible: false
name: ATPase pump mediated Ca efflux Cell1

915605
type: LocalParameter
value: 0.18

915593
type: LocalParameter
value: 1.2

915568
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000009
type: Parameter
constant: false
value: 0.0

metaid_0000037
type: Reaction
kinetic law: 915689
reactant: 915677
is version of: GO:0031586
fast: false
reversible: false
name: Open to Inactivated state transition Cell1

915701
type: LocalParameter
value: 0.2778

915677
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000041
type: Reaction
kinetic law: 915869
product: 915857
is version of: GO:0031586
fast: false
reversible: false
name: Inactivated to Shut state transition Cell2

915857
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000010
type: Parameter
constant: true
value: 26.5

metaid_0000016
type: Parameter
constant: false
value: 0.0

metaid_0000044
type: SBMLUnitsDef
unit: 915496
name: micromole

915496
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000003
type: Parameter
constant: false
value: 0.0

metaid_0000013
type: Parameter
constant: true
value: 1.6

metaid_0000007
type: Parameter
constant: true
value: 44.0

metaid_0000017
type: Parameter
constant: false
value: 0.0

metaid_0000035
type: Reaction
kinetic law: 915629
product: 915617
is version of: GO:0051209
is version of: GO:0007204
fast: false
reversible: false
name: IP3R independent Ca release Cell1

915641
type: LocalParameter
value: 0.2

915617
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000038
type: Reaction
kinetic law: 915737
modifier: 915725
product: 915713
is version of: GO:0007204
is: GO:0005220
fast: false
reversible: false
name: IP3R mediated Ca release Cell2

915761
type: LocalParameter
value: 0.2778

915749
type: LocalParameter
value: 28.0

915713
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000042
type: Reaction
kinetic law: 915893
reactant: 915881
is version of: GO:0031586
fast: false
reversible: false
name: Open to Inactivated state transition Cell2

915905
type: LocalParameter
value: 0.2778

915881
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000011
type: Parameter
constant: true
value: 20.0

metaid_0000004
type: Parameter
constant: true
value: 100.0

metaid_0000014
type: Parameter
constant: true
value: 1.6

metaid_0000008
type: Parameter
constant: true
value: 50.0

metaid_0000018
type: Parameter
constant: false
value: 0.0

metaid_0000036
type: Reaction
kinetic law: 915665
product: 915653
is version of: GO:0031586
fast: false
reversible: false
name: Inactivated to Shut state transition Cell1

915653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022