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reaction: metaid_0000169
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reaction: metaid_0000206

metaid_0000252
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629873
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335418
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metaid_0000097
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metaid_0000169
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629553
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331438
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metaid_0000103
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629633
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332749
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metaid_0000231
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629789
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629786
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334420
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metaid_0000091
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334408
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metaid_0000095
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metaid_0000133
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629451
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329644
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metaid_0000011
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329632
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metaid_0000017
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329620
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metaid_0000052
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metaid_0000226
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629759
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629756
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334180
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334168
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metaid_0000058
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metaid_0000210
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629674
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629672
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333291
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333279
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333267
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metaid_0000195
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332580
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332568
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metaid_0000194
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629622
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332544
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332532
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metaid_0000148
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330427
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metaid_0000147
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330391
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330379
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metaid_0000244
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629843
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335045
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335032
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metaid_0000111
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328643
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629395
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629393
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328631
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metaid_0000003
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328655
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metaid_0000022
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metaid_0000127
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629437
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629435
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329356
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329344
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329331
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metaid_0000193
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629621
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332508
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332496
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metaid_0000141
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629477
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629474
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330138
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330113
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metaid_0000039
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metaid_0000176
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331763
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331739
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629572
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331751
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metaid_0000239
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629828
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334804
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metaid_0000042
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334792
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334780
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metaid_0000087
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metaid_0000204
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629650
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333014
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333002
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332990
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metaid_0000082
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metaid_0000143
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629483
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629481
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330235
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330223
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330211
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metaid_0000028
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metaid_0000126
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629431
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329307
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329295
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329283
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metaid_0000125
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329259
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329247
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metaid_0000106
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629380
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629378
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328424
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metaid_0000007
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328412
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metaid_0000006
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metaid_0000065
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metaid_0000240
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334852
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334840
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334828
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metaid_0000061
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metaid_0000037
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metaid_0000157
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330860
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629523
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629521
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metaid_0000033
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330872
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metaid_0000218
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629714
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629711
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333760
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333748
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333736
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metaid_0000187
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629600
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332244
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332232
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332220
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metaid_0000171
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331498
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331510
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629559
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629557
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331523
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metaid_0000101
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metaid_0000121
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reversible: false
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629420
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329066
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metaid_0000049
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329054
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metaid_0000031
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metaid_0000119
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629413
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328982
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328970
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metaid_0000051
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328958
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metaid_0000050
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metaid_0000214
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metaid_0000057
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333459
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629686
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629684
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333471
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metaid_0000034
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metaid_0000213
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629681
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333435
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333423
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metaid_0000055
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333411
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metaid_0000182
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629589
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332004
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331992
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metaid_0000232
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629795
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629792
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334468
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334456
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334444
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metaid_0000248
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629855
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335237
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335225
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metaid_0000024
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335213
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metaid_0000115
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reactant: 328800
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629405
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328812
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328800
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metaid_0000181
type: Reaction
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reactant: 331956
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629588
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629586
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331968
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331956
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331944
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metaid_0000197
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629629
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332652
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332640
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metaid_0000164
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331161
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metaid_0000019
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331173
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metaid_0000069
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629542
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629540
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metaid_0000247
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629852
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335189
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335177
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335165
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metaid_0000246
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629849
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335141
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335129
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335117
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metaid_0000098
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metaid_0000113
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328727
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328739
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629401
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629399
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328715
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metaid_0000129
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629443
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629441
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329440
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329452
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329428
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metaid_0000178
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629578
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331836
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metaid_0000075
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331824
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metaid_0000145
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629487
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330307
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metaid_0000043
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330295
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metaid_0000059
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metaid_0000206
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629656
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333111
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333099
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333087
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metaid_0000242
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629837
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334948
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334936
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334924
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metaid_0000208
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333195
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629668
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629665
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333171
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333183
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metaid_0000107
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328448
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328461
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metaid_0000012
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328473
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629383
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629381
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metaid_0000189
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629606
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332340
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332328
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metaid_0000174
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629568
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629566
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331667
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331656
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331644
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metaid_0000221
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629729
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333904
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333892
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333880
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metaid_0000201
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332845
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629641
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629639
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metaid_0000190
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629609
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629607
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332388
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332376
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332364
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metaid_0000159
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629529
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629527
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330969
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330957
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metaid_0000236
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629819
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629816
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334660
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334648
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334636
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metaid_0000185
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629596
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332148
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332136
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332124
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metaid_0000152
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629508
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629506
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330631
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330619
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metaid_0000234
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629807
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629804
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334564
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334552
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334540
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metaid_0000137
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629464
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629462
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329957
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329945
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329933
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metaid_0000015
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metaid_0000136
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629461
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329909
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329897
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metaid_0000100
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metaid_0000117
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629409
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328898
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328885
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metaid_0000166
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629548
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629546
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331317
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331329
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331305
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metaid_0000013
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metaid_0000030
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metaid_0000168
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629552
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331401
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331389
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metaid_0000229
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629777
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629774
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334324
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metaid_0000089
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334312
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334300
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metaid_0000230
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629783
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629780
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334372
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334360
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334348
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metaid_0000130
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629446
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629444
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329500
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329488
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329476
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metaid_0000132
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329560
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629450
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329596
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329584
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329572
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metaid_0000162
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629536
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331089
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331101
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metaid_0000161
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reversible: true
name: ppERK_dimerization

629535
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629533
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331065
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331053
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metaid_0000225
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629753
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629750
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334132
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metaid_0000085
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334120
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334108
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metaid_0000224
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metaid_0000035
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334072
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334048
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334060
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629747
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629744
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metaid_0000010
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metaid_0000109
type: Reaction
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629389
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629387
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328558
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328545
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metaid_0000254
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328316
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metaid_0000223
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629741
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629738
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334012
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334000
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333988
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metaid_0000192
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629618
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332472
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332460
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metaid_0000140
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629471
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330089
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330077
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metaid_0000056
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metaid_0000175
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331691
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331715
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331703
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629571
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629569
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metaid_0000238
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629825
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334756
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334744
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334732
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metaid_0000124
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329223
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629427
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329198
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329186
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329211
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metaid_0000105
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328388
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328364
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328376
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629377
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629374
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metaid_0000029
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metaid_0000154
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629514
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629512
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330740
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330727
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330715
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metaid_0000156
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629520
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629518
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330836
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metaid_0000251
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629870
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629867
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335394
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335382
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metaid_0000217
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629708
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629705
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333700
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333676
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metaid_0000170
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629556
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331474
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331462
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metaid_0000253
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335502
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335478
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335490
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629876
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335466
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metaid_0000120
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629419
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629416
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329030
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329018
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329006
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metaid_0000134
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329668
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629457
type: LocalParameter
value: 0.1

629454
type: LocalParameter
value: 0.2

329680
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000014
type: Species
has only substance units: false
is version of: Q4QQV2
constant: false
initial concentration: 0.0
is version of: IPR002404
initial amount: NaN
is version of: C00562
boundary condition: false
in compartment: metaid_0000004

metaid_0000212
type: Reaction
kinetic law: 333399
product: 333387
reactant: 333375
reactant: 333363
is version of: GO:0051425
fast: false
reversible: true
name: binding_FRS2_to_dpEGFR_c_Cbl

629680
type: LocalParameter
value: 0.2

629678
type: LocalParameter
value: 1.0

333387
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

333375
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

333363
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000211
type: Reaction
kinetic law: 333351
product: 333339
reactant: 333327
reactant: 333315
is version of: GO:0031625
fast: false
reversible: true
name: binding_c_Cbl_to_Crk_C3G_pFRS2_dpEGFR

629677
type: LocalParameter
value: 0.2

629675
type: LocalParameter
value: 0.5

333339
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

333327
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

333315
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000180
type: Reaction
kinetic law: 331932
product: 331920
reactant: 331908
reactant: 331896
is version of: GO:0051425
fast: false
reversible: true
name: binding_FRS2_to_pTrkA_endo

629585
type: LocalParameter
value: 0.1

629582
type: LocalParameter
value: 5.0

331920
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

331908
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

331896
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000227
type: Reaction
kinetic law: 334240
product: 334228
reactant: 334216
reactant: 334204
is version of: GO:0019899
fast: false
reversible: true

629765
type: LocalParameter
value: 2.0

629762
type: LocalParameter
value: 15.625

334228
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

334216
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

334204
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000196
type: Reaction
kinetic law: 332628
product: 332616
reactant: 332604
is version of: GO:0016567
fast: false
reversible: false
name: pShc_pTrkA_ubiquitination

629626
type: LocalParameter
value: 6.3E-4

332616
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

332604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000149
type: Reaction
reactant: 330451
reversible: false
kinetic law: 330499
product: 330475
name: FRS2_dpEGFR_c_Cbl_ubiq_dissociation
is version of: GO:0043161
fast: false
product: 330463
product: 330487

330451
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

629498
type: LocalParameter
value: 0.001

330475
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

330463
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

330487
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000163
type: Reaction
kinetic law: 331149
product: 331137
reactant: 331125
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: Rap1_GTP_dephosphorylation

629539
type: LocalParameter
value: 1.166E-4

331137
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

331125
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000245
type: Reaction
kinetic law: 335105
product: 335093
product: 335081
reactant: 335069
is version of: GO:0004709
fast: false
reversible: false

629846
type: LocalParameter
value: 0.3

335093
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

335081
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

335069
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000093
type: Species
constant: false
initial concentration: 0.0
has part: Q99MC6
has part: CHEBI:15996
initial amount: NaN
has part: Q01986
boundary condition: false
has only substance units: false
has part: Q62636
in compartment: metaid_0000004

metaid_0000112
type: Reaction
kinetic law: 328703
product: 328691
reactant: 328679
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: pDOKdephosphorylation

629398
type: LocalParameter
value: 1.0E-5

629396
type: LocalParameter
value: 0.002

328691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

328679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000128
type: Reaction
kinetic law: 329416
product: 329404
reactant: 329392
reactant: 329380
is version of: GO:0005070
fast: false
reversible: true
name: binding_Grb2_SOS_pShc_dpEGFR

629440
type: LocalParameter
value: 0.2

629438
type: LocalParameter
value: 10.0

329404
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

329392
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

329380
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000142
type: Reaction
kinetic law: 330199
product: 330186
reactant: 330174
reactant: 330162
is version of: GO:0031625
fast: false
reversible: true
name: binding_c_Cbl_to_FRS2_dpEGFR

629480
type: LocalParameter
value: 0.2

629478
type: LocalParameter
value: 0.5

330186
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

330174
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

330162
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000177
type: Reaction
kinetic law: 331812
product: 331800
reactant: 331787
is version of: GO:0006468
fast: false
reversible: false
name: Shc_pTrkA_endo_phosphorylation

629575
type: LocalParameter
value: 0.1

331800
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

331787
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000144
type: Reaction
kinetic law: 330283
product: 330271
reactant: 330259
is version of: GO:0016567
fast: false
reversible: false
name: pFRS2_dpEGFR_c_Cbl_ubiquitiation

629484
type: LocalParameter
value: 0.05

330271
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000060
type: Species
has part: D4A244
initial amount: NaN
has part: Q9QX70
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000004
boundary condition: false
constant: false
has part: Q8K4S7

330259
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000179
type: Reaction
kinetic law: 331884
product: 331872
reactant: 331860
is version of: GO:0006468
fast: false
reversible: false
name: pFRS2_pTrkA_phosphorylation

629579
type: LocalParameter
value: 2.0

331872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

331860
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000205
type: Reaction
kinetic law: 333075
product: 333062
product: 333050
reactant: 333038
is version of: GO:0043241
fast: false
reversible: false
name: Grb2_SOS_pShc_pTrkA_endo_degradation

629653
type: LocalParameter
value: 4.2E-4

333062
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

333050
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

333038
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000084

metaid_0000241
type: Reaction
kinetic law: 334912
product: 334900
product: 334888
reactant: 334876
is version of: GO:0004709
fast: false
reversible: false

629834
type: LocalParameter
value: 0.2

334900
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

334888
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

334876
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

metaid_0000158
type: Reaction
fast: false
is version of: GO:0006470
is part of: GO:0051389
reactant: 330908
product: 330921
kinetic law: 330945
reversible: false
name: pMEK_dephosphorylation
is version of: http://identifiers.org/ec-code/3.1.3.16
modifier: 330933

330908
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

330921
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

629526
type: LocalParameter
value: 15.657

629524
type: LocalParameter
value: 3.0

metaid_0000219
type: Reaction
kinetic law: 333820
product: 333808
reactant: 333796
reactant: 333784
is part of: GO:0000187
fast: false
reversible: true
name: binding_ERK_to_pMEK

629720
type: LocalParameter
value: 0.6

629717
type: LocalParameter
value: 16.304

333808
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

333796
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

333784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000188
type: Reaction
kinetic law: 332304
product: 332292
product: 332280
reactant: 332268
is version of: GO:0043241
fast: false
reversible: false
name: Shc_pTrkA_endo_degradation

629603
type: LocalParameter
value: 4.2E-4

332292
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

332280
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

332268
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000173
type: Reaction
kinetic law: 331632
product: 331620
reactant: 331608
reactant: 331596
is version of: GO:0051425
fast: false
reversible: true
name: binding_FRS2_to_pTrkA

629565
type: LocalParameter
value: 0.1

629563
type: LocalParameter
value: 5.0

331620
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

331608
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

331596
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000172
type: Reaction
is version of: GO:0051425
kinetic law: 331584
is version of: GO:0042169
fast: false
reactant: 331547
product: 331571
reversible: true
name: binding_pShc_to_pTrkA
reactant: 331559

629562
type: LocalParameter
value: 0.2

629560
type: LocalParameter
value: 10.0

331547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

331571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

331559
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

ORG:
  orgname: Tokyo University
n:
  given: Shinya
  family: Kuroda

metaid_0000220
type: Reaction
kinetic law: 333868
product: 333856
reactant: 333844
reactant: 333832
is part of: GO:0000187
fast: false
reversible: true
name: binding_ERK_to_ppMEK

629726
type: LocalParameter
value: 0.6

629723
type: LocalParameter
value: 16.304

333856
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

333844
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

333832
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000122
type: Reaction
reactant: 329090
fast: false
product: 329102
reversible: false
is: GO:0043161
kinetic law: 329138
product: 329114
name: Shc_dpEGFR_c_Cbl_ubiq_Degradation
product: 329126

329090
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

329102
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

629423
type: LocalParameter
value: 0.001

329114
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

329126
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000200
type: Reaction
fast: false
name: binding_Grb2_SOS_pShc_to_pTrkA
product: 332797
is version of: GO:0042169
is version of: GO:0051425
reversible: true
reactant: 332785
reactant: 332773
kinetic law: 332809

332797
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

332785
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

332773
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

629638
type: LocalParameter
value: 0.2

629636
type: LocalParameter
value: 10.0

metaid_0000215
type: Reaction
name: RAP1_GTP_dephosphorylation
kinetic law: 333544
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 333508
product: 333520
is version of: GO:0006470
modifier: 333532

629698
type: LocalParameter
value: 1.0

629689
type: LocalParameter
value: 2.0

333508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

333520
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000184
type: Reaction
kinetic law: 332112
product: 332100
product: 332088
reactant: 332076
is version of: GO:0043241
fast: false
reversible: false
name: pFRS2_pTrkA_degradation

629593
type: LocalParameter
value: 0.0022

332100
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

332088
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

332076
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

W3 CDTF: Wed Dec 21 10:59:39 GMT 2005

metaid_0000183
type: Reaction
kinetic law: 332064
product: 332052
product: 332040
reactant: 332028
is version of: GO:0043241
fast: false
reversible: false
name: FRS2_pTrkA_degradation

629592
type: LocalParameter
value: 0.0022

332052
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

332040
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

332028
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000151
type: Reaction
kinetic law: 330607
product: 330595
reactant: 330583
reactant: 330571
is part of: GO:0046580
fast: false
reversible: true
name: binding_RasGAP_to_pDOK

629505
type: LocalParameter
value: 0.01

629502
type: LocalParameter
value: 0.12

330595
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

330583
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

330571
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000150
type: Reaction
is version of: GO:0043161
product: 330547
name: pFRS2_dpEGFR_c_Cbl_ubiq_dissociation
product: 330523
reversible: false
kinetic law: 330559
fast: false
product: 330535
reactant: 330511

330547
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

330523
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

629499
type: LocalParameter
value: 0.001

330535
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

330511
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000233
type: Reaction
kinetic law: 334528
product: 334516
reactant: 334504
reactant: 334492
is version of: GO:0019899
fast: false
reversible: true

629801
type: LocalParameter
value: 1.2

629798
type: LocalParameter
value: 9.375

334516
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

334504
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

334492
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000249
type: Reaction
kinetic law: 335309
product: 335297
product: 335285
is version of: GO:0043241
product: 335273
fast: false
reactant: 335261
reversible: false

629858
type: LocalParameter
value: 0.001

335297
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

335285
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

335273
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

335261
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

metaid_0000135
type: Reaction
kinetic law: 329885
product: 329873
reactant: 329861
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: pShc_dephosphorylation

629458
type: LocalParameter
value: 0.005

329873
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

329861
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

metaid_0000116
type: Reaction
kinetic law: 328873
product: 328861
reactant: 328849
reactant: 328836
is version of: GO:0042169
fast: false
reversible: true
name: binding_Shc_LdpEGFR

629408
type: LocalParameter
value: 0.2

629406
type: LocalParameter
value: 10.0

328861
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

328849
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

328836
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000198
type: Reaction
kinetic law: 332712
product: 332700
reactant: 332688
reactant: 332676
is version of: GO:0042169
fast: false
reversible: true
name: binding_Crk_C3G_to_pFRS2_pTrkA

629632
type: LocalParameter
value: 0.2

629630
type: LocalParameter
value: 1.0

332700
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

332688
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

332676
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

metaid_0000165
type: Reaction
name: Ras_GDP_phosphorylation
modifier: 331281
is version of: GO:0005085
product: 331245
fast: false
modifier: 331269
is version of: GO:0006468
kinetic law: 331293
reversible: false
modifier: 331257
reactant: 331233

331245
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

629545
type: LocalParameter
value: 0.02

629543
type: LocalParameter
value: 2.0

331233
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000167
type: Reaction
kinetic law: 331377
product: 331365
reactant: 331353
is version of: GO:0006468
is version of: GO:0004716
fast: false
reversible: false
name: TrkA_phosphorylation

629549
type: LocalParameter
value: 1.0

331365
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

331353
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000114
type: Reaction
kinetic law: 328788
product: 328776
reactant: 328763
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: SOSdephosphorylation

629402
type: LocalParameter
value: 0.002

328776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

328763
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000228
type: Reaction
kinetic law: 334288
product: 334276
reactant: 334264
reactant: 334252
is version of: GO:0019899
fast: false
reversible: true

629771
type: LocalParameter
value: 2.0

629768
type: LocalParameter
value: 15.625

334276
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

334264
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

334252
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000131
type: Reaction
kinetic law: 329548
product: 329536
reactant: 329524
is version of: GO:0016567
fast: false
reversible: false
name: Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiquitination

629447
type: LocalParameter
value: 0.05

329536
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

329524
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000146
type: Reaction
kinetic law: 330355
product: 330343
reactant: 330331
is version of: GO:0006468
is version of: GO:0004716
fast: false
reversible: false
name: FRS2_dpEGFR_c_Cbl_phosphorylation

629488
type: LocalParameter
value: 1.0

330343
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

330331
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000207
type: Reaction
kinetic law: 333159
product: 333147
reactant: 333135
is part of: GO:0051396
fast: false
reversible: true
name: form_NGFreceptor

629662
type: LocalParameter
value: 2.7778E-4

629659
type: LocalParameter
value: 8.333E-4

333147
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

333135
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000099

metaid_0000160
type: Reaction
reversible: false
is version of: GO:0006470
product: 331017
fast: false
name: pMEK_ERK_dephosphorylation
reactant: 331005
kinetic law: 331041
is part of: GO:0051389
modifier: 331029
is version of: http://identifiers.org/ec-code/3.1.3.16

331017
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

331005
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

629532
type: LocalParameter
value: 15.657

629530
type: LocalParameter
value: 3.0

metaid_0000243
type: Reaction
kinetic law: 335008
product: 334996
product: 334984
reactant: 334972
is version of: GO:0004709
fast: false
reversible: false

629840
type: LocalParameter
value: 0.2

334996
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

334984
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

334972
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000209
type: Reaction
reversible: true
reactant: 333219
name: binding_pShc_to_dpEGFR_c_Cbl
kinetic law: 333255
is version of: GO:0051425
reactant: 333231
is version of: GO:0042169
product: 333243
fast: false

333219
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

629671
type: LocalParameter
value: 0.2

629669
type: LocalParameter
value: 10.0

333231
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

333243
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000110
type: Reaction
kinetic law: 328619
product: 328606
reactant: 328594
reactant: 328582
is version of: GO:0051425
fast: false
reversible: true
name: binding_cCbI_dpEGFR

629392
type: LocalParameter
value: 0.2

629390
type: LocalParameter
value: 0.5

328606
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

328594
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

328582
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000108
type: Reaction
product: 328521
reactant: 328509
is version of: GO:0017124
is version of: GO:0005070
name: binding_pSOS_Grb2
fast: false
is version of: GO:0005068
kinetic law: 328533
reactant: 328497
reversible: true

328521
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

328509
type: SpeciesReference
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species: metaid_0000010

629386
type: LocalParameter
value: 0.0168

629384
type: LocalParameter
value: 0.03

328497
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000222
type: Reaction
reversible: false
is version of: GO:0043241
product: 333952
product: 333940
reactant: 333928
modifier: 333964
kinetic law: 333976
name: c_Raf_Ras_GTP_dissociation
fast: false

333952
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

333940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

333928
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

629735
type: LocalParameter
value: 1.0

629732
type: LocalParameter
value: 10.0

metaid_0000203
type: Reaction
reactant: 332930
name: Crk_C3G_pFRS2_pTrkA_endo_degradation
product: 332966
is version of: GO:0043241
kinetic law: 332978
product: 332954
fast: false
reversible: false
product: 332942

332930
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000081

332966
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

629647
type: LocalParameter
value: 4.2E-4

332954
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

332942
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

metaid_0000191
type: Reaction
kinetic law: 332448
product: 332436
reactant: 332424
reactant: 332412
is version of: GO:0005070
fast: false
reversible: true
name: binding_Grb2_SOS_to_pShc_pTrkA

629615
type: LocalParameter
value: 0.2

629612
type: LocalParameter
value: 10.0

332436
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

332424
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

332412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000202
type: Reaction
product: 332894
product: 332882
fast: false
reversible: false
kinetic law: 332918
is version of: GO:0043241
product: 332906
reactant: 332869
name: Crk_C3G_pFRS2_pTrkA_degradation

332894
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

332882
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

629644
type: LocalParameter
value: 0.0022

332906
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

332869
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

metaid_0000237
type: Reaction
kinetic law: 334720
product: 334708
product: 334696
reactant: 334684
is version of: GO:0004709
fast: false
reversible: false

629822
type: LocalParameter
value: 0.5

334708
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

334696
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

334684
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000123
type: Reaction
kinetic law: 329174
product: 329162
reactant: 329150
is version of: GO:0016567
fast: false
reversible: false
name: pShc_dpEGFR_c_Cbl_ubiquitination

629424
type: LocalParameter
value: 0.05

329162
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

329150
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000104
type: Reaction
kinetic law: 328352
product: 328340
reactant: 328328
is part of: GO:0045741
fast: false
reversible: true
name: form_EGFreceptor

629371
type: LocalParameter
value: 1.0E-4

629370
type: LocalParameter
value: 1.0E-4

328340
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

328328
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

metaid_0000139
type: Reaction
kinetic law: 330065
product: 330053
reactant: 330041
reactant: 330029
is: GO:0051425
fast: false
reversible: true
name: binding_pFRS2_to_L_dpEGFR

629470
type: LocalParameter
value: 0.2

629468
type: LocalParameter
value: 1.0

330053
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

330041
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

330029
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000186
type: Reaction
kinetic law: 332208
product: 332196
product: 332184
reactant: 332172
is version of: GO:0043241
fast: false
reversible: false
name: pShc_pTrkA_degradation

629597
type: LocalParameter
value: 0.0022

332196
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

332184
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

332172
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000153
type: Reaction
kinetic law: 330703
modifier: 330691
product: 330679
reactant: 330667
is version of: GO:0006468
fast: false
reversible: false
name: SOS_phosphorylation

629511
type: LocalParameter
value: 25.641

629509
type: LocalParameter
value: 1.0

330679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

330667
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000235
type: Reaction
kinetic law: 334624
product: 334612
reactant: 334600
reactant: 334588
is version of: GO:0019899
fast: false
reversible: true

629813
type: LocalParameter
value: 1.2

629810
type: LocalParameter
value: 9.375

334612
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

334600
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

334588
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000250
type: Reaction
kinetic law: 335357
product: 335345
reactant: 335333
reactant: 335321
is part of: GO:0000188
fast: false
reversible: false

629864
type: LocalParameter
value: 0.24

629861
type: LocalParameter
value: 15.0

335345
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

335333
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

335321
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000155
type: Reaction
kinetic law: 330800
product: 330788
reactant: 330776
reactant: 330764
is version of: GO:0000185
fast: false
reversible: true
name: binding_B_Raf_to_Rap1_GTP

629517
type: LocalParameter
value: 0.5

629515
type: LocalParameter
value: 60.0

330788
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

330776
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

330764
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000138
type: Reaction
kinetic law: 330017
product: 330005
reactant: 329993
reactant: 329981
is: GO:0051425
fast: false
reversible: true
name: binding_L_dpEGFR_to_FRS2

629467
type: LocalParameter
value: 0.2

629465
type: LocalParameter
value: 1.0

330005
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

329993
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

329981
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000216
type: Reaction
modifier: 333604
reversible: false
reactant: 333556
kinetic law: 333664
fast: false
is version of: GO:0006468
modifier: 333652
product: 333568
modifier: 333640
modifier: 333580
modifier: 333592
name: Dok_phosphorylation
modifier: 333628
modifier: 333616

333556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

629702
type: LocalParameter
value: 0.1

629699
type: LocalParameter
value: 0.02

333568
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000118
type: Reaction
kinetic law: 328946
product: 328934
reactant: 328922
is version of: GO:0016567
fast: false
reversible: false
name: dpEGFR_c_Cbl_ubiquitination

629412
type: LocalParameter
value: 0.05

328934
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

328922
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

W3 CDTF: Wed May 16 15:23:03 BST 2012

ORG:
  orgname: EMBL-EBI
n:
  given: Lu
  family: Li