BIOMD0000000048
type: SBMLModel
reaction: metaid_0000032
species: metaid_0000018
species: metaid_0000004
reaction: metaid_0000042
species: metaid_0000014
reaction: metaid_0000046
reaction: metaid_0000052
created:
  W3 CDTF: Wed Nov 23 13:53:17 GMT 2005
occurs in: http://identifiers.org/taxonomy/10116
reaction: metaid_0000037
reaction: metaid_0000034
occurs in: GO:0007173
is described by: http://identifiers.org/pubmed/10514507
reaction: metaid_0000040
species: metaid_0000008
creator:
  ORG:
    orgname: Stellenbosh University
  n:
    given: Jacky L
    family: Snoep
species: metaid_0000024
species: metaid_0000007
length unit: length
species: metaid_0000023
reaction: metaid_0000033
reaction: metaid_0000043
is: MODEL6624193277
species: metaid_0000021
species: metaid_0000017
reaction: metaid_0000047
modified:
  W3 CDTF: Thu Jun 06 12:39:37 BST 2013
species: metaid_0000013
species: metaid_0000016
reaction: metaid_0000030
species: metaid_0000012
curated: true
reaction: metaid_0000035
reaction: metaid_0000041
time units: metaid_0000003
reaction: metaid_0000028
reaction: metaid_0000038
reaction: metaid_0000044
species: metaid_0000006
compartment: metaid_0000003
species: metaid_0000026
volume units: metaid_0000323
units def: metaid_0000053
species: metaid_0000022
species: metaid_0000005
reaction: metaid_0000048
species: metaid_0000020
reaction: metaid_0000031
notes: SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 The model correctly reproduces all the figures from the paper. The curation has been done using SBMLodeSolver.
area units: area
species: metaid_0000015
reaction: metaid_0000051
species: metaid_0000011
name: Kholodenko1999_EGFRsignaling
reaction: metaid_0000036
species: metaid_0000010
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lu
    family: Li
species: metaid_0000009
species: metaid_0000025
reaction: metaid_0000029
reaction: metaid_0000039
reaction: metaid_0000045
reaction: metaid_0000050
substance units: metaid_0000053
species: metaid_0000019
reaction: metaid_0000049

metaid_0000032
type: Reaction
is version of: GO:0042169
name: binding_of_PLCg_to_RP
reversible: true
is version of: GO:0051425
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000048#c13fa78b_3fe7_45ea_bd92_b64b8abd8656
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000010
type: Species
has version: P10686
name: (EGF_EGFR)2_PLCg
has only substance units: false
has version: Q9QX70
initial concentration: 0.0
has version: P24135
initial amount: NaN
constant: false
in compartment: metaid_0000003
boundary condition: false

metaid_0000003
type: Compartment
notes: Default size of compartment is 1e-10 litre by comparison with the article.
is: GO:0005737
constant: true
size: 3.0E-12
spatial dimensions: 3.0
name: cytoplasm

http://identifiers.org/biomodels.db/BIOMD0000000048#_2950d1c1_a633_4481_928c_0434f8cef354
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000009
type: Species
has version: P24135
has version: P10686
constant: false
has only substance units: false
name: PLCg
is version of: IPR001192
in compartment: metaid_0000003
initial amount: NaN
initial concentration: 105.0
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000048#c7218b1b_1701_4bb1_83fe_224a0d9489fe
type: LocalParameter
value: 0.2

http://identifiers.org/biomodels.db/BIOMD0000000048#_0961bca8_b13c_407b_b4f9_dd9263f6945b
type: LocalParameter
value: 0.06

http://identifiers.org/biomodels.db/BIOMD0000000048#caa48495_412c_4bd9_96fc_4408afdf6c5f
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
is version of: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: (EGF_EGFR)2-P

metaid_0000018
type: Species
is version of: Q5M824
constant: false
boundary condition: false
has only substance units: false
initial concentration: 150.0
initial amount: NaN
in compartment: metaid_0000003
name: Shc

metaid_0000004
type: Species
is: P07522
constant: false
boundary condition: false
has only substance units: false
initial concentration: 680.0
initial amount: NaN
in compartment: metaid_0000003
name: Epidermal_Growth_Factor

metaid_0000042
type: Reaction
fast: false
reversible: true
name: dissociation_of_RShp

http://identifiers.org/biomodels.db/BIOMD0000000048#_8d5d86ce_8788_4354_bed0_699c4c22ea1b
type: LocalParameter
value: 9.0E-4

http://identifiers.org/biomodels.db/BIOMD0000000048#b1b09d7d_6a4f_4a36_804a_3dab159cfefa
type: LocalParameter
value: 0.3

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000021
type: Species
is version of: Q5M824
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: Shc-P

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000020
type: Species
has part: Q5M824
in compartment: metaid_0000003
name: (EGF_EGFR)_Shc-P
boundary condition: false
has part: Q9QX70
initial amount: NaN
initial concentration: 0.0
constant: false
has only substance units: false

metaid_0000014
type: Species
initial amount: NaN
has only substance units: false
name: (EGF_EGFR)2_Grb2
has part: P62994
boundary condition: false
has part: Q9QX70
constant: false
in compartment: metaid_0000003
initial concentration: 0.0

metaid_0000046
type: Reaction
is version of: GO:0005070
is version of: GO:0017124
reversible: true
fast: false
is version of: GO:0005068
name: binding_of_SOS_to_RShG

http://identifiers.org/biomodels.db/BIOMD0000000048#_682bcd81_c9f5_45c3_8dd8_3269f9b3d568
type: LocalParameter
value: 0.0214

http://identifiers.org/biomodels.db/BIOMD0000000048#a8309517_cea8_4693_846a_9f1b00d4651f
type: LocalParameter
value: 0.01

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000015
type: Species
is: Q9Z1I1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 34.0
initial amount: NaN
in compartment: metaid_0000003
name: SOS

http://identifiers.org/biomodels.db/BIOMD0000000048#f154c412_0e56_4c50_97a3_53b30deb4d06
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000024
type: Species
constant: false
in compartment: metaid_0000003
initial concentration: 0.0
has part: Q9Z1I1
has part: Q9QX70
boundary condition: false
has part: P62994
name: (EGF_EGFR)2_Shc_Grb2_SOS
has only substance units: false
has part: Q5M824
initial amount: NaN

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000022
type: Species
name: (EGF_EGFR)2_Shc_Grb2
in compartment: metaid_0000003
initial amount: NaN
constant: false
initial concentration: 0.0
has part: Q9QX70
boundary condition: false
has only substance units: false
has part: Q5M824
has part: P62994

metaid_0000052
type: Reaction
is version of: GO:0030845
fast: false
reversible: true
name: translocation_of_PLCgP

http://identifiers.org/biomodels.db/BIOMD0000000048#bbba6f8c_9f11_4fd9_b4e3_d2025f99b5dc
type: LocalParameter
value: 0.03

http://identifiers.org/biomodels.db/BIOMD0000000048#_017c6684_0add_4a93_acff_92cd0d8b31e1
type: LocalParameter
value: 1.0

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000026
type: Species
name: PLCgP-I
is version of: IPR001192
has version: P10686
in compartment: metaid_0000003
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 0.0
has version: P24135

http://identifiers.org/biomodels.db/BIOMD0000000048#baf9ebca_b4b9_4872_9c82_6afe36c64c54
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000012
type: Species
has only substance units: false
has version: IPR001192
boundary condition: false
name: PLCg-P
initial amount: NaN
initial concentration: 0.0
in compartment: metaid_0000003
is version of: P24135
constant: false
is version of: P10686

metaid_0000037
type: Reaction
name: binding_of_SOS_to_RG
fast: false
is version of: GO:0017124
is version of: GO:0005070
is version of: GO:0005068
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000048#_2764321c_1c00_49bf_a314_25baf9a555d6
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

http://identifiers.org/biomodels.db/BIOMD0000000048#_2e9c2a39_cf55_4f14_b636_fb07d274aa3d
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000016
type: Species
constant: false
boundary condition: false
has part: Q9Z1I1
has part: P62994
name: (EGF_EGFR)2_Grb2_SOS
has part: Q9QX70
initial concentration: 0.0
has only substance units: false
initial amount: NaN
in compartment: metaid_0000003

http://identifiers.org/biomodels.db/BIOMD0000000048#_5aea3250_7944_4807_8589_93919092c766
type: LocalParameter
value: 0.06

http://identifiers.org/biomodels.db/BIOMD0000000048#d35584a4_0abf_4148_88d7_b032983e660f
type: LocalParameter
value: 0.01

metaid_0000034
type: Reaction
fast: false
reversible: true
name: dissociation_of_RPLCgP

http://identifiers.org/biomodels.db/BIOMD0000000048#_8e93cab5_a988_4bb1_934e_9a7648e51811
type: LocalParameter
value: 0.006

http://identifiers.org/biomodels.db/BIOMD0000000048#_0a271bbe_5ca5_4374_b553_9bafa329e86f
type: LocalParameter
value: 0.3

http://identifiers.org/biomodels.db/BIOMD0000000048#_916312b4_c23e_41da_8d4f_e4efac0103ba
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

http://identifiers.org/biomodels.db/BIOMD0000000048#_13c11fbc_2202_4f60_affd_46b6f068642f
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

http://identifiers.org/biomodels.db/BIOMD0000000048#ef6c7c7c_8167_4ce7_b3be_0c8b6c11d9b6
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
in compartment: metaid_0000003
name: (EGF_EGFR)2_PLCg-P
boundary condition: false
constant: false
has only substance units: false
initial concentration: 0.0
has version: Q9QX70
has version: P24135
initial amount: NaN
has version: P10686

metaid_0000040
type: Reaction
is version of: GO:0051425
fast: false
is version of: GO:0042169
name: binding_of_Shc_to_RP
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000048#_107a968d_c842_44b3_9d0c_ad24a0f3c5af
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000019
type: Species
initial concentration: 0.0
has part: Q9QX70
initial amount: NaN
in compartment: metaid_0000003
boundary condition: false
has part: Q5M824
name: (EGF_EGFR)2_Shc
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/BIOMD0000000048#dd309c95_951a_4a73_8f3d_cde8dcfb24d3
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

http://identifiers.org/biomodels.db/BIOMD0000000048#_72b9a5b3_93bd_4993_91da_2ab54d273728
type: LocalParameter
value: 0.6

http://identifiers.org/biomodels.db/BIOMD0000000048#_9b39a8ff_27d9_40ec_bc6b_ca07e5fc2bd3
type: LocalParameter
value: 0.09

http://identifiers.org/biomodels.db/BIOMD0000000048#_3fb0bee9_252c_4b8c_87a5_d5abae7e2be5
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000007
type: Species
constant: false
has part: P07522
boundary condition: false
initial concentration: 0.0
name: (EGF_EGFR)2
has part: Q9QX70
in compartment: metaid_0000003
has only substance units: false
initial amount: NaN

metaid_0000023
type: Species
has part: P62994
name: Shc_Grb2
has only substance units: false
has part: Q5M824
initial concentration: 0.0
in compartment: metaid_0000003
initial amount: NaN
boundary condition: false
constant: false

metaid_0000033
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.37
is version of: GO:0006468
fast: false
name: phosphorylation_of_PLCg
is version of: GO:0004716
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000048#d3d3c0ed_5572_4928_bac1_e1cf8511105e
type: LocalParameter
value: 0.05

http://identifiers.org/biomodels.db/BIOMD0000000048#_1435f63c_fff8_4e63_b2b1_6d7ae0cb7772
type: LocalParameter
value: 1.0

http://identifiers.org/biomodels.db/BIOMD0000000048#_62b0c286_9629_4113_b1b9_af044130bea3
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

http://identifiers.org/biomodels.db/BIOMD0000000048#_4e9a2e1d_7f47_4e37_9648_afb78c467035
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000043
type: Reaction
is version of: GO:0006470
notes: Dephosphorylation is irriversible, according to artical.
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
name: dephosphorylation_of_ShP
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000048#c0ff8bba_5b41_4500_bbb4_6c352fea314f
type: LocalParameter
value: 340.0

http://identifiers.org/biomodels.db/BIOMD0000000048#e4ef91da_43f4_4d70_aee3_38c198af3a5f
type: LocalParameter
value: 1.7

http://identifiers.org/biomodels.db/BIOMD0000000048#d3cd636a_f359_4b18_8703_1fc7d3574294
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000017
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: Grb2_SOS
constant: false
in compartment: metaid_0000003
has part: Q9Z1I1
has part: P62994
initial concentration: 0.0

metaid_0000047
type: Reaction
fast: false
reversible: true
name: dissociation_of_RShGS

http://identifiers.org/biomodels.db/BIOMD0000000048#d1da0756_8720_49f9_97aa_a117ed3e08d3
type: LocalParameter
value: 2.4E-4

http://identifiers.org/biomodels.db/BIOMD0000000048#_0ba47fca_6466_4eb7_b47f_93684b088ab2
type: LocalParameter
value: 0.12

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000025
type: Species
has part: P62994
name: Shc_Grb2_SOS
has only substance units: false
has part: Q5M824
initial amount: NaN
initial concentration: 0.0
has part: Q9Z1I1
constant: false
in compartment: metaid_0000003
boundary condition: false

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000013
type: Species
is: P62994
constant: false
boundary condition: false
has only substance units: false
initial concentration: 85.0
initial amount: NaN
in compartment: metaid_0000003
name: Grb2

metaid_0000030
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.37
reversible: true
name: phosphorylation_of_R2
is version of: GO:0004716
is version of: GO:0006468

http://identifiers.org/biomodels.db/BIOMD0000000048#a976f554_161e_4f00_a05a_e91c49b5cf8f
type: LocalParameter
value: 0.01

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type: LocalParameter
value: 1.0

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species: metaid_0000007

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000035
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0006470
notes: Dephosphorylation is irriversible, according to article.
reversible: false
fast: false
name: dephosphorylation_of_PLCgP

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type: LocalParameter
value: 100.0

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type: LocalParameter
value: 1.0

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000041
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.37
is version of: GO:0006468
is version of: GO:0004716
fast: false
reversible: true
name: phosphorylation_of_RSh

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type: LocalParameter
value: 0.06

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type: LocalParameter
value: 6.0

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000028
type: Reaction
name: EGF_binds_to_EGFR
is: GO:0048408
is part of: GO:0045741
is: GO:0005154
fast: false
reversible: true

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species: metaid_0000006

metaid_0000006
type: Species
initial amount: NaN
initial concentration: 0.0
has part: Q9QX70
constant: false
has part: P07522
name: EGF_EGFR
in compartment: metaid_0000003
boundary condition: false
has only substance units: false

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type: LocalParameter
value: 0.06

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type: LocalParameter
value: 0.003

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species: metaid_0000004

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species: metaid_0000005

metaid_0000005
type: Species
is version of: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000003
name: EGFR

metaid_0000038
type: Reaction
fast: false
reversible: true
name: dissociation_of_RGS

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type: LocalParameter
value: 0.0045

http://identifiers.org/biomodels.db/BIOMD0000000048#_918f1045_b54d_4b0e_b7e0_15826fe5c671
type: LocalParameter
value: 0.03

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type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

http://identifiers.org/biomodels.db/BIOMD0000000048#_5698230f_6414_40fa_b414_370202f474a7
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

http://identifiers.org/biomodels.db/BIOMD0000000048#_1d5bae74_4647_4985_8d7f_a91c1b39aed5
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000044
type: Reaction
name: binding_of_Grb2_to_RShP
is version of: GO:0042169
is version of: GO:0051425
reversible: true
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000048#d1cf7072_a6a9_4d39_b0e4_29bbc880bc18
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

http://identifiers.org/biomodels.db/BIOMD0000000048#_6693fbe1_9610_4bad_bfbc_e9accf46c125
type: LocalParameter
value: 0.1

http://identifiers.org/biomodels.db/BIOMD0000000048#_0a2d38e0_bb1c_4d93_8744_aac44491b8b3
type: LocalParameter
value: 0.003

http://identifiers.org/biomodels.db/BIOMD0000000048#_76f39600_7b2c_4932_9936_fb10589bc446
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

http://identifiers.org/biomodels.db/BIOMD0000000048#f96fe4c6_5e27_4406_91eb_a662b9986708
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000053
type: SBMLUnitsDef
notes: Default unit of substance redefined to nanomole.
name: nanomole

http://identifiers.org/biomodels.db/BIOMD0000000048#d3076a17_6d41_4fec_b619_a0c38e85230d
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000048
type: Reaction
is version of: GO:0051425
is version of: GO:0042169
fast: false
name: binding_of_Grb2_to_ShP
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000048#_1761f0c0_4af3_492e_ad2d_6faeef58e3ab
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

http://identifiers.org/biomodels.db/BIOMD0000000048#_612f86ea_8619_4ed5_9000_25b1060c2ef6
type: LocalParameter
value: 0.1

http://identifiers.org/biomodels.db/BIOMD0000000048#_923c9f6a_5635_46d7_ab4e_d49bc6205445
type: LocalParameter
value: 0.003

http://identifiers.org/biomodels.db/BIOMD0000000048#_676687b1_7ef7_4f44_931e_4aea56fc54de
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

http://identifiers.org/biomodels.db/BIOMD0000000048#_022389ce_49e7_4919_89b8_1d4061837aae
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000031
type: Reaction
notes: According to the artical, this dephosphorylation of RP should be irriversible.
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation_of_RP
is version of: GO:0006470

http://identifiers.org/biomodels.db/BIOMD0000000048#ac956032_d1b5_4150_85c8_51cf701195ff
type: LocalParameter
value: 50.0

http://identifiers.org/biomodels.db/BIOMD0000000048#_4294a763_14ba_48af_96eb_bd7e4b90e988
type: LocalParameter
value: 450.0

http://identifiers.org/biomodels.db/BIOMD0000000048#da4926b9_4bec_4cbc_adec_a6bb4a16a605
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

http://identifiers.org/biomodels.db/BIOMD0000000048#_6a8c197f_bcc9_40d3_8f57_2cdcc4a6dba9
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000051
type: Reaction
is version of: GO:0042169
is version of: GO:0051425
name: association_of_RShP_and_GS
fast: false
reversible: true

http://identifiers.org/biomodels.db/BIOMD0000000048#_160b8b5c_a554_43e6_825e_1c33dd0448fb
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

http://identifiers.org/biomodels.db/BIOMD0000000048#_8b4c5cc9_69a3_4cb7_b2bc_e6137385ae70
type: LocalParameter
value: 0.0429

http://identifiers.org/biomodels.db/BIOMD0000000048#_22f4e84b_34a5_444d_82f0_064609b1197a
type: LocalParameter
value: 0.009

http://identifiers.org/biomodels.db/BIOMD0000000048#cab5cafa_b72e_408a_9513_bb6894b61403
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

http://identifiers.org/biomodels.db/BIOMD0000000048#e1957140_4e8d_4478_a9a0_a37a45894949
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000036
type: Reaction
reversible: true
name: binding_of_Grb2_to_RP
is version of: GO:0051425
fast: false
is version of: GO:0042169

http://identifiers.org/biomodels.db/BIOMD0000000048#_7e5ff990_ff59_449b_913a_73f5af69fef6
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

http://identifiers.org/biomodels.db/BIOMD0000000048#eea9c953_8096_4e8d_94e3_b7883364bcd5
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

http://identifiers.org/biomodels.db/BIOMD0000000048#a08a91d2_375e_4ca2_8acc_117a12649124
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

http://identifiers.org/biomodels.db/BIOMD0000000048#c8ea07b5_f946_47d1_9f8a_cf2016a86095
type: LocalParameter
value: 0.05

http://identifiers.org/biomodels.db/BIOMD0000000048#_4e6b5e8a_50dd_447e_af26_2b0244f4b497
type: LocalParameter
value: 0.003

metaid_0000029
type: Reaction
is version of: GO:0046983
fast: false
reversible: true
name: association_of_2_Ra_into_dimer

http://identifiers.org/biomodels.db/BIOMD0000000048#_19b7003d_b11f_42ad_bbdd_3aeaece5f697
type: LocalParameter
value: 0.1

http://identifiers.org/biomodels.db/BIOMD0000000048#_3475cd04_c202_42c6_be4d_e3e8feb98d46
type: LocalParameter
value: 0.01

http://identifiers.org/biomodels.db/BIOMD0000000048#df823ef8_390a_497d_8251_cc4044fe778b
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

http://identifiers.org/biomodels.db/BIOMD0000000048#f002c7f3_9251_4bd4_a069_6e6532e207cc
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000006

metaid_0000039
type: Reaction
fast: false
reversible: true
name: dissociation_of_GS

http://identifiers.org/biomodels.db/BIOMD0000000048#_8bc60889_aa0c_461d_a657_eaff5373e7dc
type: LocalParameter
value: 1.0E-4

http://identifiers.org/biomodels.db/BIOMD0000000048#_9af34bd2_a370_4f5e_89f3_68d00be18f1f
type: LocalParameter
value: 0.0015

http://identifiers.org/biomodels.db/BIOMD0000000048#f050329f_fd4d_4f63_9340_3655d332cb72
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

http://identifiers.org/biomodels.db/BIOMD0000000048#_0c72e810_8a1c_474c_98b2_30fac3bccd2f
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

http://identifiers.org/biomodels.db/BIOMD0000000048#_06148f28_84e4_4526_a03b_fa364a107223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000045
type: Reaction
fast: false
reversible: true
name: dissociation_of_RShG

http://identifiers.org/biomodels.db/BIOMD0000000048#_470a389f_1b76_4d48_92a9_e0d696b679ea
type: LocalParameter
value: 9.0E-4

http://identifiers.org/biomodels.db/BIOMD0000000048#_534b0aa6_4cbb_48bb_875c_15f9e0801466
type: LocalParameter
value: 0.3

http://identifiers.org/biomodels.db/BIOMD0000000048#_8d04fb98_e8ba_4a16_bfd0_0b572c6ae1bf
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

http://identifiers.org/biomodels.db/BIOMD0000000048#c3c4c128_6436_4b01_a1ac_1e8fe1c2170e
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

http://identifiers.org/biomodels.db/BIOMD0000000048#ab1f3548_d1b6_43c2_9a22_c7b3f1611b18
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000050
type: Reaction
fast: false
reversible: true
name: dissociation_of_ShGS

http://identifiers.org/biomodels.db/BIOMD0000000048#_7bb101a8_a514_430d_a887_4078ddbe9047
type: LocalParameter
value: 0.021

http://identifiers.org/biomodels.db/BIOMD0000000048#_166ef0b7_240f_4022_883b_abb7b9eb19ff
type: LocalParameter
value: 0.1

http://identifiers.org/biomodels.db/BIOMD0000000048#a625aa83_31dd_4f77_9b2d_0bee1c33d002
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

http://identifiers.org/biomodels.db/BIOMD0000000048#a391e679_07e2_46c3_9130_03d424ba8e00
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

http://identifiers.org/biomodels.db/BIOMD0000000048#_1370f4cf_9542_445d_b90a_fd3885592edd
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000049
type: Reaction
is version of: GO:0017124
is version of: GO:0005070
reversible: true
name: binding_of_SOS_to_ShG
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000048#_24e98c87_b29e_4bf1_8556_c40a6ee0d20e
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

http://identifiers.org/biomodels.db/BIOMD0000000048#_29c24d55_c90d_48d2_9939_f3dd3b4bbbe3
type: LocalParameter
value: 0.064

http://identifiers.org/biomodels.db/BIOMD0000000048#d47a6c11_0f7f_4779_b8df_6b66f71b356a
type: LocalParameter
value: 0.03

http://identifiers.org/biomodels.db/BIOMD0000000048#_3a835da2_f4d2_4da6_b59e_8fc5c8909dbe
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

http://identifiers.org/biomodels.db/BIOMD0000000048#_1be83fdd_a979_400e_8d15_5d7373177e27
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015