BIOMD0000000033
type: SBMLModel
species: metaid_0000071
reaction: metaid_0000100
parameter: metaid_0000007
units def: metaid_0000110
species: metaid_0000075
parameter: metaid_0000031
parameter: metaid_0000019
occurs in: http://identifiers.org/taxonomy/131567
species: metaid_0000083
species: metaid_0000074
species: metaid_0000078
parameter: metaid_0000018
is version of: GO:0048011
species: metaid_0000063
species: metaid_0000054
area units: area
parameter: metaid_0000005
parameter: metaid_0000006
parameter: metaid_0000027
parameter: metaid_0000047
parameter: metaid_0000028
reaction: metaid_0000098
parameter: metaid_0000048
species: metaid_0000062
name: Brown2004_NGF_EGF_signaling
reaction: metaid_0000089
compartment: metaid_0000051
species: metaid_0000066
parameter: metaid_0000012
species: metaid_0000057
parameter: metaid_0000013
reaction: metaid_0000085
parameter: metaid_0000035
reaction: metaid_0000086
parameter: metaid_0000034
reaction: metaid_0000108
reaction: metaid_0000109
reaction: metaid_0000104
is: MODEL6619514794
species: metaid_0000069
parameter: metaid_0000030
reaction: metaid_0000092
reaction: metaid_0000105
reaction: metaid_0000093
parameter: metaid_0000020
is version of: rno04010
curated: true
species: metaid_0000081
species: metaid_0000072
species: metaid_0000076
parameter: metaid_0000016
parameter: metaid_0000017
parameter: metaid_0000039
species: metaid_0000052
is version of: GO:0007173
parameter: metaid_0000003
parameter: metaid_0000004
species: metaid_0000079
reaction: metaid_0000096
reaction: metaid_0000097
species: metaid_0000060
reaction: metaid_0000088
species: metaid_0000064
parameter: metaid_0000045
parameter: metaid_0000046
species: metaid_0000055
parameter: metaid_0000011
reaction: metaid_0000084
species: metaid_0000059
parameter: metaid_0000041
parameter: metaid_0000042
parameter: metaid_0000009
parameter: metaid_0000033
species: metaid_0000067
species: metaid_0000058
reaction: metaid_0000091
parameter: metaid_0000038
is version of: GO:0000165
substance units: metaid_0000110

metaid_0000071
type: Species
is version of: P63086
is version of: P21708
constant: false
boundary condition: false
has only substance units: false
initial concentration: 600000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000051
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0

metaid_0000100
type: Reaction
modifier: 916500
product: 916488
reversible: true
is version of: GO:0004707
is version of: http://identifiers.org/ec-code/2.7.1.37
kinetic law: 916512
reactant: 916476
fast: false
name: P90Rsk activation

metaid_0000072
type: Species
is version of: P63086
is version of: P21708
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

916488
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

metaid_0000061
type: Species
has version: Q63531
has version: Q9Z1I2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

916476
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000060
type: Species
has version: Q63531
has version: Q9Z1I2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000007
type: Parameter
constant: true
value: 694.731

metaid_0000110
type: SBMLUnitsDef
unit: 915682
name: item (default)

915682
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000075
type: Species
boundary condition: false
has only substance units: false
initial concentration: 120000.0
constant: false
in compartment: metaid_0000051
has version: Q63484
has version: P47197
has version: P47196
initial amount: NaN

metaid_0000031
type: Parameter
constant: true
value: 10.6737

metaid_0000019
type: Parameter
constant: true
value: 185.759

metaid_0000083
type: Species
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000074
type: Species
is version of: GO:0005942
has part: IPR015433
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000078
type: Species
is version of: Q9QYV3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000018
type: Parameter
constant: true
value: 62464.6

metaid_0000063
type: Species
is version of: IPR003577
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000054
type: Species
is: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 80000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000005
type: Parameter
constant: true
value: 1.38209E-7

metaid_0000006
type: Parameter
constant: true
value: 0.00723811

metaid_0000027
type: Parameter
constant: true
value: 8.8912

metaid_0000047
type: Parameter
constant: true
value: 0.126329

metaid_0000028
type: Parameter
constant: true
value: 3496490.0

metaid_0000098
type: Reaction
name: Erk deactivation
modifier: 916404
reactant: 916380
kinetic law: 916416
fast: false
product: 916392
is version of: GO:0000188
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.16

metaid_0000082
type: Species
is: GO:0000159
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

916380
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

916392
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000048
type: Parameter
constant: true
value: 1061.71

metaid_0000062
type: Species
is version of: IPR003577
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000089
type: Reaction
fast: false
modifier: 915972
reactant: 915948
name: SOS activation by NGF
is version of: GO:0004716
reversible: true
product: 915960
is version of: http://identifiers.org/ec-code/2.7.1.37
kinetic law: 915984

metaid_0000057
type: Species
has part: P25427
has part: P35739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

915948
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000058
type: Species
is version of: Q9Z1I1
is version of: ENSRNOP00000009359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

915960
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000059
type: Species
is version of: Q9Z1I1
is version of: ENSRNOP00000009359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000066
type: Species
is version of: P11345
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000012
type: Parameter
constant: true
value: 896896.0

metaid_0000013
type: Parameter
constant: true
value: 32.344

metaid_0000085
type: Reaction
kinetic law: 915791
product: 915779
product: 915767
reactant: 915755
is version of: GO:0007175
fast: false
reversible: false
name: EFG unbinding

915779
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

915767
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000052
type: Species
is: P07522
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0002E7
initial amount: NaN
in compartment: metaid_0000051

915755
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

metaid_0000055
type: Species
has part: P07522
has part: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000035
type: Parameter
constant: true
value: 0.0566279

metaid_0000086
type: Reaction
fast: false
reactant: 915803
name: NGF binding
is version of: GO:0051396
reversible: false
is: GO:0048406
kinetic law: 915840
reactant: 915816
product: 915828

915803
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000053
type: Species
is: P25427
constant: false
boundary condition: false
has only substance units: false
initial concentration: 456000.0
initial amount: NaN
in compartment: metaid_0000051

915816
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000056
type: Species
is: P35739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10000.0
initial amount: NaN
in compartment: metaid_0000051

915828
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000034
type: Parameter
constant: true
value: 272056.0

metaid_0000108
type: Reaction
name: BRaf activation by Rap1
reactant: 916862
product: 916874
modifier: 916886
kinetic law: 916898
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
is version of: GO:0000185

916862
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

metaid_0000067
type: Species
is version of: Q99MC6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

916874
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

metaid_0000068
type: Species
is version of: Q99MC6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000080
type: Species
has version: Q62636
has version: P10113
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000109
type: Reaction
kinetic law: 916949
modifier: 916937
product: 916924
reactant: 916911
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: BRaf deactivation by PPase

916924
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

916911
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

metaid_0000104
type: Reaction
kinetic law: 916705
modifier: 916693
product: 916681
reactant: 916669
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: Raf1 deactivation by Akt

metaid_0000076
type: Species
constant: false
in compartment: metaid_0000051
boundary condition: false
has version: P47197
has version: P47196
initial concentration: 0.0
initial amount: NaN
has only substance units: false
has version: Q63484

916681
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000065
type: Species
is version of: P11345
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

916669
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

metaid_0000069
type: Species
is version of: P36506
is version of: Q01986
constant: false
boundary condition: false
has only substance units: false
initial concentration: 600000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000030
type: Parameter
constant: true
value: 763523.0

metaid_0000092
type: Reaction
kinetic law: 916128
modifier: 916116
product: 916104
reactant: 916092
is: GO:0046580
fast: false
reversible: true
name: Ras deactivation

metaid_0000064
type: Species
is: P50904
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

916104
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

916092
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000105
type: Reaction
is version of: GO:0004716
kinetic law: 916753
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
modifier: 916741
reactant: 916717
product: 916729
fast: false
name: C3G activation

916717
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000077
type: Species
is version of: Q9QYV3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

916729
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

metaid_0000093
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.37
name: Raf1 activation by Ras
is version of: GO:0008349
modifier: 916164
reversible: true
is version of: GO:0000185
kinetic law: 916176
product: 916152
reactant: 916140
fast: false

916152
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

916140
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000020
type: Parameter
constant: true
value: 4768350.0

metaid_0000081
type: Species
is: P47736
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000016
type: Parameter
constant: true
value: 1432410.0

metaid_0000017
type: Parameter
constant: true
value: 0.884096

metaid_0000039
type: Parameter
constant: true
value: 146.912

metaid_0000003
type: Parameter
constant: true
value: 2.18503E-5

metaid_0000004
type: Parameter
constant: true
value: 0.0121008

metaid_0000079
type: Species
has version: Q62636
has version: P10113
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000096
type: Reaction
product: 916296
is version of: http://identifiers.org/ec-code/2.7.1.37
reactant: 916284
modifier: 916308
name: Erk activation
fast: false
is version of: GO:0004708
reversible: true
kinetic law: 916320
is version of: GO:0000187

916296
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

916284
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000070
type: Species
is version of: P36506
is version of: Q01986
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000097
type: Reaction
kinetic law: 916368
modifier: 916356
product: 916344
reactant: 916332
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: Mek deactivation

916344
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

916332
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000088
type: Reaction
is version of: GO:0004716
name: SOS activation by EGF
modifier: 915924
kinetic law: 915936
is version of: http://identifiers.org/ec-code/2.7.1.37
reversible: true
fast: false
reactant: 915900
product: 915912

915900
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

915912
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000045
type: Parameter
constant: true
value: 2.20995

metaid_0000046
type: Parameter
constant: true
value: 1025460.0

metaid_0000011
type: Parameter
constant: true
value: 1611.97

metaid_0000084
type: Reaction
is: GO:0048408
kinetic law: 915743
is version of: GO:0045741
reactant: 915707
fast: false
reversible: false
name: EGF binding
product: 915730
reactant: 915719

915707
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

915730
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

915719
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

metaid_0000041
type: Parameter
constant: true
value: 1.40145

metaid_0000042
type: Parameter
constant: true
value: 10965.6

metaid_0000009
type: Parameter
constant: true
value: 389.428

metaid_0000033
type: Parameter
constant: true
value: 0.0771067

metaid_0000091
type: Reaction
kinetic law: 916080
modifier: 916068
product: 916056
reactant: 916044
is: GO:0046579
fast: false
reversible: true
name: Ras activation

916056
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

916044
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

metaid_0000038
type: Parameter
constant: true
value: 119355.0

W3 CDTF: Fri Jun 10 15:09:32 BST 2005

metaid_0000025
type: Parameter
constant: true
value: 9.85367

metaid_0000026
type: Parameter
constant: true
value: 1007340.0

W3 CDTF: Wed Jul 11 18:30:02 BST 2012

metaid_0000015
type: Parameter
constant: true
value: 1509.36

metaid_0000087
type: Reaction
kinetic law: 915888
product: 915876
product: 915864
reactant: 915852
is version of: GO:0051395
fast: false
reversible: false
name: NGF unbinding

915876
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

915864
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

915852
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000107
type: Reaction
kinetic law: 916850
modifier: 916838
product: 916826
reactant: 916814
fast: false
reversible: true
name: Rap1 deactivation

916826
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

916814
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000099
type: Reaction
kinetic law: 916464
modifier: 916452
product: 916440
reactant: 916428
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: Raf1 deactivation by PPase

916440
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

916428
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

metaid_0000073
type: Species
is version of: GO:0005942
has part: IPR015433
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051

metaid_0000102
type: Reaction
is version of: GO:0008349
kinetic law: 916608
reversible: true
reactant: 916572
product: 916584
modifier: 916596
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
name: PI3K activation by Ras

916572
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

916584
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000103
type: Reaction
kinetic law: 916656
modifier: 916644
product: 916632
reactant: 916620
is version of: GO:0045860
fast: false
reversible: true
name: Akt activation

916632
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

916620
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000010
type: Parameter
constant: true
value: 2112.66

metaid_0000032
type: Parameter
constant: true
value: 184912.0

metaid_0000095
type: Reaction
reversible: true
fast: false
name: Mek activation by B-Raf
is version of: GO:0000186
product: 916248
is version of: GO:0004709
kinetic law: 916272
is version of: http://identifiers.org/ec-code/2.7.1.37
modifier: 916260
reactant: 916236

916248
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

916236
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000022
type: Parameter
constant: true
value: 157948.0

metaid_0000044
type: Parameter
constant: true
value: 295990.0

metaid_0000040
type: Parameter
constant: true
value: 12876.2

metaid_0000008
type: Parameter
constant: true
value: 6086070.0

metaid_0000090
type: Reaction
kinetic law: 916032
modifier: 916020
product: 916008
reactant: 915996
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: SOS deactivation

916008
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

915996
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_1000110
type: SBMLUnitsDef
unit: 915694
name: minute (default)

915694
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000029
type: Parameter
constant: true
value: 0.0213697

metaid_0000050
type: Parameter
constant: true
value: 1.08795E7

metaid_0000049
type: Parameter
constant: true
value: 441.287

metaid_0000014
type: Parameter
constant: true
value: 35954.3

metaid_0000036
type: Parameter
constant: true
value: 653951.0

metaid_0000037
type: Parameter
constant: true
value: 15.1212

metaid_0000023
type: Parameter
constant: true
value: 2.83243

metaid_0000024
type: Parameter
constant: true
value: 518753.0

metaid_0000106
type: Reaction
kinetic law: 916801
modifier: 916789
product: 916777
reactant: 916765
is: GO:0046582
fast: false
reversible: true
name: Rap1 activation

916777
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

916765
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000094
type: Reaction
modifier: 916212
reactant: 916188
is version of: GO:0000186
name: Mek activation by Raf1
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
product: 916200
is version of: GO:0004709
kinetic law: 916224

916188
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

916200
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000021
type: Parameter
constant: true
value: 125.089

metaid_0000043
type: Parameter
constant: true
value: 27.265

metaid_0000101
type: Reaction
kinetic law: 916560
modifier: 916548
product: 916536
reactant: 916524
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: PI3K activation by EGFR

916536
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

916524
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

ORG:
  orgname: Cornell University
n:
  given: Ryan
  family: Gutenkunst