BIOMD0000000030
type: SBMLModel
is version of: GO:0000165
parameter: metaid_0001047
parameter: metaid_0000020
species: metaid_0000015
species: metaid_0000005
species: metaid_0000007
species: metaid_0000009
parameter: metaid_0001048
parameter: metaid_0000028
parameter: metaid_0000021
curated: true
occurs in: http://identifiers.org/taxonomy/8355
parameter: metaid_0000029
parameter: metaid_0000035
species: metaid_0000016
reaction: metaid_0000050
parameter: metaid_0000030
parameter: metaid_0000036
reaction: metaid_0000056
parameter: metaid_0000038
compartment: metaid_0000004
parameter: metaid_0001045
reaction: metaid_0000063
parameter: metaid_0000026
reaction: metaid_0000051
parameter: metaid_0000031
reaction: metaid_0000053
species: metaid_0000010
parameter: metaid_0000039
reaction: metaid_0001055
parameter: metaid_0000032
reaction: metaid_0000054
species: metaid_0000014
name: Markevich2004_MAPK_AllRandomElementary
parameter: metaid_0000034
reaction: metaid_0000060
species: metaid_0001014
reaction: metaid_0000047
reaction: metaid_0000049
reaction: metaid_0000061
parameter: metaid_0000041
parameter: metaid_0000019
parameter: metaid_0001049
parameter: metaid_0000022
notes: This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
length unit: length
reaction: metaid_0001054
reaction: metaid_0000055
parameter: metaid_0000023
parameter: metaid_0000037
species: metaid_0000018
reaction: metaid_0000046
reaction: metaid_0000057
species: metaid_0001001
reaction: metaid_0000058
parameter: metaid_0000043
parameter: metaid_0000045
is described by: http://identifiers.org/pubmed/14744999
species: metaid_0000011
species: metaid_0000013
species: metaid_0001013
units def: metaid_0000003
volume units: metaid_0000323
parameter: metaid_0000033
reaction: metaid_0001056
reaction: metaid_0000059
reaction: metaid_0000048
parameter: metaid_0000027
parameter: metaid_0000040
species: metaid_0000006
species: metaid_0000008
parameter: metaid_0000042
substance units: metaid_0000003
time units: metaid_0000017
area units: area
species: metaid_0000017
species: metaid_0001000
parameter: metaid_0000024
parameter: metaid_0001046

metaid_0001047
type: Parameter
constant: true
value: 0.092
name: h11

metaid_0000020
type: Parameter
constant: true
value: 1.0
name: k_1

metaid_0000015
type: Species
name: MAPK_MAPKK_Y
has only substance units: false
in compartment: metaid_0000004
has part: Q05116
boundary condition: false
initial concentration: 0.0
initial amount: NaN
constant: false
has part: P26696

metaid_0000004
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000005
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 800.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK

metaid_0000007
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PT

metaid_0000009
type: Species
is: Q05116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 180.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPKK

metaid_0001048
type: Parameter
constant: true
value: 1.0
name: h12

metaid_0000028
type: Parameter
constant: true
value: 0.032
name: k7

metaid_0000021
type: Parameter
constant: true
value: 0.01
name: k2

metaid_0000029
type: Parameter
constant: true
value: 1.0
name: k_7

metaid_0000035
type: Parameter
constant: true
value: 0.01
name: h_3

metaid_0000016
type: Species
initial concentration: 0.0
initial amount: NaN
constant: false
in compartment: metaid_0000004
has part: P26696
has part: Q05116
has only substance units: false
name: MAPK_MAPKK_T
boundary condition: false

metaid_0000050
type: Reaction
kinetic law: 063413
name: binding of MAPKK on Thr site of MAPK
fast: false
reactant: 063377
reactant: 063389
is homolog to: REACT 1780
is version of: GO:0031434
is homolog to: REACT 495
product: 063401
reversible: true
is version of: GO:0051019

063377
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

063389
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063401
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000030
type: Parameter
constant: true
value: 15.0
name: k8

metaid_0000036
type: Parameter
constant: true
value: 0.01
name: h4

metaid_0000056
type: Reaction
kinetic law: 063689
product: 063677
product: 063665
reactant: 063653
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK-PT and MKP

063677
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000010
type: Species
is: Q90W58
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000004
name: MKP

063665
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

063653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000017
type: Species
constant: false
boundary condition: false
name: MAPK-PT_MKP_Y
initial concentration: 0.0
has part: P26696
has part: Q90W58
in compartment: metaid_0000004
has only substance units: false
initial amount: NaN

metaid_0000038
type: Parameter
constant: true
value: 0.5
name: h5

metaid_0001045
type: Parameter
constant: true
value: 0.045
name: h10

metaid_0000063
type: Reaction
kinetic law: 063955
product: 063943
product: 063931
reactant: 063919
is version of: GO:0043241
fast: false
reversible: true
name: Dissociation MAPK and MKP

063943
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063931
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

063919
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001001

metaid_0001001
type: Species
has only substance units: false
initial concentration: 0.0
name: MAPK_MKP_Y
boundary condition: false
in compartment: metaid_0000004
has part: P26696
constant: false
has part: Q90W58
initial amount: NaN

metaid_0000026
type: Parameter
constant: true
value: 1.0
name: k_5

metaid_0000051
type: Reaction
reversible: false
is homolog to: REACT 136
kinetic law: 063461
is homolog to: REACT 2247
is version of: GO:0004708
fast: false
product: 063437
reactant: 063425
product: 063449
is version of: GO:0018107
is version of: http://identifiers.org/ec-code/2.7.12.2
name: thr phosphorylation of MAPK

063437
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

063425
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

063449
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000031
type: Parameter
constant: true
value: 0.045
name: h1

metaid_0000053
type: Reaction
product: 063533
is homolog to: REACT 2247
name: tyr phosphorylation of MAPK
kinetic law: 063557
is version of: GO:0018108
is version of: GO:0004708
product: 063545
is version of: GO:0000187
is homolog to: REACT 136
is version of: http://identifiers.org/ec-code/2.7.12.2
reversible: false
reactant: 063521
fast: false

063533
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PP

063545
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063521
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000012
type: Species
in compartment: metaid_0000004
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 0.0
has part: Q05116
name: MAPK-PT_MAPKK
has part: P26696

metaid_0000039
type: Parameter
constant: true
value: 0.086
name: h6

metaid_0001055
type: Reaction
name: dephosphorylation of Thr on MAPKK-PP
reversible: false
kinetic law: 064039
fast: false
product: 064027
reactant: 064015
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0000188

064027
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001014

metaid_0001014
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: MAPK-PY_MKP_T
initial concentration: 0.0
in compartment: metaid_0000004
has part: P26696
has part: Q90W58
boundary condition: false

064015
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001013

metaid_0001013
type: Species
initial concentration: 0.0
constant: false
has only substance units: false
initial amount: NaN
in compartment: metaid_0000004
has part: Q90W58
boundary condition: false
name: MAPK-PP_MKP_Y
has part: P26696

metaid_0000032
type: Parameter
constant: true
value: 1.0
name: h_1

metaid_0000054
type: Reaction
kinetic law: 063605
product: 063593
reactant: 063581
reactant: 063569
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Tyr site of MAPK-PP

063593
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000013
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: MAPK-PP_MKP_T
in compartment: metaid_0000004
boundary condition: false
initial concentration: 0.0
has part: P26696
has part: Q90W58

063581
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063569
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000014
type: Species
initial amount: NaN
in compartment: metaid_0000004
constant: false
has only substance units: false
boundary condition: false
name: MAPK-PY_MKP_Y
initial concentration: 0.0
has part: Q90W58
has part: P26696

metaid_0000034
type: Parameter
constant: true
value: 1.0
name: h3

metaid_0000060
type: Reaction
kinetic law: 063823
product: 063811
product: 063798
reactant: 063786
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK and MKP

063811
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063798
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

063786
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001000

metaid_0001000
type: Species
constant: false
name: MAPK_MKP_T
initial concentration: 0.0
initial amount: NaN
has only substance units: false
boundary condition: false
has part: Q90W58
in compartment: metaid_0000004
has part: P26696

metaid_0000047
type: Reaction
reversible: false
is homolog to: REACT 136
is version of: GO:0018108
is homolog to: REACT 2247
kinetic law: 063269
product: 063244
product: 063256
name: tyr phosphorylation of MAPK
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0004708
reactant: 063232

063244
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000006
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PY

063256
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063232
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000049
type: Reaction
kinetic law: 063365
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
is homolog to: REACT 136
reactant: 063329
name: thr phosphorylation of MAPK
product: 063353
reversible: false
product: 063341
is version of: GO:0004708
is version of: GO:0000187
is version of: GO:0018107

063329
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
has part: P26696
initial amount: NaN
in compartment: metaid_0000004
has only substance units: false
has part: Q05116
initial concentration: 0.0
name: MAPK-PY_MAPKK
constant: false
boundary condition: false

063353
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063341
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000061
type: Reaction
kinetic law: 063871
product: 063859
reactant: 063847
reactant: 063835
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on the Tyr site of MAPK-PY

063859
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

063847
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063835
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000041
type: Parameter
constant: true
value: 0.01
name: h7

metaid_0000019
type: Parameter
constant: true
value: 0.02
name: k1

metaid_0001049
type: Parameter
constant: true
value: 0.01
name: h_12

metaid_0000022
type: Parameter
constant: true
value: 0.032
name: k3

metaid_0001054
type: Reaction
kinetic law: 064003
product: 063991
reactant: 063979
reactant: 063967
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Thr site of MAPK-PP

063991
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001013

063979
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063967
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000055
type: Reaction
product: 063629
is version of: GO:0000188
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 063641
name: dephosphorylation of Tyr on MAPKK-PP
is version of: GO:0006470
reversible: false
fast: false
reactant: 063617

063629
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

063617
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000023
type: Parameter
constant: true
value: 1.0
name: k_3

metaid_0000037
type: Parameter
constant: true
value: 1.0
name: h_4

metaid_0000018
type: Species
boundary condition: false
initial concentration: 0.0
has only substance units: false
constant: false
has part: Q90W58
name: MAPK-PT_MKP_T
in compartment: metaid_0000004
has part: P26696
initial amount: NaN

metaid_0000046
type: Reaction
is homolog to: REACT 495
product: 063208
is homolog to: REACT 1780
kinetic law: 063220
is version of: GO:0051019
reactant: 063184
name: binding MAPKK on Tyr site of MAPK
reversible: true
reactant: 063196
is version of: GO:0031434
fast: false

063208
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

063184
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

063196
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000057
type: Reaction
kinetic law: 063774
product: 063762
reactant: 063749
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation of MAPK-PT

063762
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001000

063749
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000058
type: Reaction
kinetic law: 063737
product: 063725
reactant: 063713
reactant: 063701
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Thr site of MAPK-PT

063725
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

063713
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

063701
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000043
type: Parameter
constant: true
value: 0.47
name: h8

metaid_0000045
type: Parameter
constant: true
value: 0.0018
name: h_9

metaid_0000003
type: SBMLUnitsDef
unit: 063172
name: nanomole (default)

063172
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000033
type: Parameter
constant: true
value: 0.092
name: h2

metaid_0001056
type: Reaction
kinetic law: 064088
product: 064076
product: 064063
reactant: 064051
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK-PY and MKP

064076
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

064063
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

064051
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001014

metaid_0000059
type: Reaction
kinetic law: 063907
product: 063895
reactant: 063883
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation of MAPK-PY

063895
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0001001

063883
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000048
type: Reaction
fast: false
is version of: GO:0031434
reactant: 063281
reactant: 063293
name: binding of MAPKK on MAPK-PY
product: 063305
kinetic law: 063317
is homolog to: REACT 495
is version of: GO:0051019
is homolog to: REACT 1780
reversible: true

063281
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

063293
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063305
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000027
type: Parameter
constant: true
value: 0.01
name: k6

metaid_0000040
type: Parameter
constant: true
value: 0.0011
name: h_6

metaid_0000042
type: Parameter
constant: true
value: 1.0
name: h_7

metaid_0000024
type: Parameter
constant: true
value: 15.0
name: k4

metaid_0001046
type: Parameter
constant: true
value: 1.0
name: h_10

metaid_0000025
type: Parameter
constant: true
value: 0.02
name: k5

metaid_0000044
type: Parameter
constant: true
value: 0.14
name: h9

metaid_0000052
type: Reaction
reactant: 063485
kinetic law: 063509
reversible: true
name: binding MAPK-PT and MAPKK
reactant: 063473
is version of: GO:0051019
fast: false
is homolog to: REACT 495
product: 063497
is homolog to: REACT 1780

063485
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

063473
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

063497
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

W3 CDTF: Thu May 26 09:51:45 BST 2005

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

W3 CDTF: Tue May 15 22:43:15 BST 2012