BIOMD0000000029
type: SBMLModel
species: metaid_0000005
compartment: metaid_0000004
units def: metaid_0000003
reaction: metaid_0000029
parameter: metaid_0000022
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nicolas
    family: Le Novère
parameter: metaid_0000014
reaction: metaid_0000032
volume units: metaid_0000323
notes: The model corresponds to the schema 3 of Markevich et al 2004, as described in the figure 2 and the supplementary table S3, and modelled using Michaelis-Menten like kinetics. Phosphorylations follow distributive random kinetics, while dephosphorylations follow an ordered mechanism. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2007 The BioModels Team. For more information see theterms of use .
species: metaid_0000006
time units: metaid_0000017
parameter: metaid_0000017
reaction: metaid_0000028
area units: area
parameter: metaid_0000021
reaction: metaid_0000031
parameter: metaid_0000025
name: Markevich2004_MAPK_phosphoRandomMM
modified:
  W3 CDTF: Tue May 15 22:42:56 BST 2012
is: MODEL6618620128
parameter: metaid_0000013
species: metaid_0000007
reaction: metaid_0000027
created:
  W3 CDTF: Tue May 24 11:57:06 BST 2005
curated: true
parameter: metaid_0000019
parameter: metaid_0000016
is version of: GO:0000165
reaction: metaid_0000030
length unit: length
occurs in: http://identifiers.org/taxonomy/8355
parameter: metaid_0000023
parameter: metaid_0000024
species: metaid_0000008
species: metaid_0000010
substance units: metaid_0000003
parameter: metaid_0000011
parameter: metaid_0000020
parameter: metaid_0000015
species: metaid_0000009
parameter: metaid_0000012
is described by: http://identifiers.org/pubmed/14744999
reaction: metaid_0000026
parameter: metaid_0000018

metaid_0000005
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 800.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK

metaid_0000004
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000003
type: SBMLUnitsDef
unit: 051390
name: nanomole (default)

051390
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

metaid_0000029
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
reactant: 051596
kinetic law: 051656
is homolog to: REACT 136
modifier: 051644
reversible: false
is version of: GO:0004708
is version of: GO:0000187
is version of: GO:0018108
name: phosphorylation of ERK-PT on Tyr
product: 051608
modifier: 051632
fast: false
modifier: 051620

051596
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000007
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PT

metaid_0000006
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PY

051608
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PP

metaid_0000009
type: Species
is: Q05116
constant: true
boundary condition: false
has only substance units: false
initial concentration: 180.0
initial amount: NaN
in compartment: metaid_0000004
name: MEK

metaid_0000022
type: Parameter
constant: true
value: 0.06
name: kcat6

metaid_0000014
type: Parameter
constant: true
value: 0.007
name: kcat2

metaid_0000032
type: Reaction
reactant: 051813
product: 051825
reversible: false
name: dephosphorylation of ERK-PY
kinetic law: 051873
is version of: http://identifiers.org/ec-code/3.1.3.16
modifier: 051837
fast: false
modifier: 051861
is version of: GO:0006470
modifier: 051849

051813
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

051825
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000010
type: Species
is: Q90W58
constant: true
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000004
name: MKP3

metaid_0000017
type: Parameter
constant: true
value: 300.0
name: Km4

metaid_0000028
type: Reaction
reactant: 051536
modifier: 051572
reversible: false
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
is version of: GO:0018107
kinetic law: 051584
modifier: 051560
name: phosphorylation of ERK on Thr
fast: false
product: 051548
is version of: GO:0004708
is homolog to: REACT 136

051536
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

051548
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000021
type: Parameter
constant: true
value: 18.0
name: Km6

metaid_0000031
type: Reaction
fast: false
reversible: false
product: 051752
is version of: http://identifiers.org/ec-code/3.1.3.16
modifier: 051764
modifier: 051776
is version of: GO:0006470
kinetic law: 051800
name: dephosphorylation of ERK-PT
reactant: 051740
modifier: 051788

051752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

051740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000025
type: Parameter
constant: true
value: 40.0
name: Km8

metaid_0000013
type: Parameter
constant: true
value: 40.0
name: Km2

metaid_0000027
type: Reaction
is version of: GO:0004708
reversible: false
is version of: GO:0000187
is homolog to: REACT 2247
modifier: 051498
modifier: 051486
fast: false
is version of: GO:0018107
product: 051474
modifier: 051510
kinetic law: 051523
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 136
reactant: 051462
name: phosphorylation of ERK-PY on Thr

051474
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

051462
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000019
type: Parameter
constant: true
value: 22.0
name: Km5

metaid_0000016
type: Parameter
constant: true
value: 0.008
name: kcat3

metaid_0000030
type: Reaction
modifier: 051692
reversible: false
product: 051680
is version of: GO:0006470
is version of: GO:0000188
reactant: 051668
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 051728
fast: false
modifier: 051716
name: dephosphorylation of ERK-PP on Tyr
modifier: 051704

051680
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

051668
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000023
type: Parameter
constant: true
value: 34.0
name: Km7

metaid_0000024
type: Parameter
constant: true
value: 0.108
name: kcat7

metaid_0000011
type: Parameter
constant: true
value: 410.0
name: Km1

metaid_0000020
type: Parameter
constant: true
value: 0.084
name: kcat5

metaid_0000015
type: Parameter
constant: true
value: 20.0
name: Km3

metaid_0000012
type: Parameter
constant: true
value: 1.08
name: kcat1

metaid_0000026
type: Reaction
is homolog to: REACT 136
name: phosphorylation of ERK on Tyr
is version of: GO:0018108
modifier: 051438
reversible: false
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 051414
kinetic law: 051450
is homolog to: REACT 2247
is version of: GO:0004708
fast: false
modifier: 051426
reactant: 051402

051414
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

051402
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000005

metaid_0000018
type: Parameter
constant: true
value: 0.45
name: kcat4