BIOMD0000000019
type: SBMLModel
parameter: metaid_0000191
reaction: metaid_0000213
reaction: metaid_0000335
parameter: metaid_0000189
parameter: metaid_0000137
species: metaid_0000047
units def: metaid_0000327
parameter: metaid_0000154
reaction: metaid_0000236
parameter: metaid_0000203
reaction: metaid_0000297
reaction: metaid_0000256
parameter: metaid_0000178
reaction: metaid_0000271
species: metaid_0000019
parameter: metaid_0000126
reaction: metaid_0000225
reaction: metaid_0000240
reaction: metaid_0000245
reaction: metaid_0000254
parameter: metaid_0000211
reaction: metaid_0000260
reaction: metaid_0000309
species: metaid_0000054
species: metaid_0000042
species: metaid_0000016
species: metaid_0000083
parameter: metaid_0000160
parameter: metaid_0000149
species: blabla 2
reaction: metaid_0000220
species: metaid_0000035
reaction: metaid_0000336
species: metaid_0000018
species: metaid_0000085
time units: metaid_0000322
reaction: metaid_0000268
parameter: metaid_0000140
reaction: metaid_0000283
parameter: metaid_0000138
is version of: GO:0007173
parameter: metaid_0000164
reaction: metaid_0000331
reaction: metaid_0000237
reaction: metaid_0000257
reaction: metaid_0000266
reaction: metaid_0000272
species: blabla 1
substance units: metaid_0000321
reaction: metaid_0000320
species: metaid_0000071
species: metaid_0000089
parameter: metaid_0000172
reaction: metaid_0000232
species: metaid_0000006
species: metaid_0000073
parameter: metaid_0000152
reaction: metaid_0000295
reaction: metaid_0000221
reaction: metaid_0000343
reaction: metaid_0000305
rule: metaid_0000465
species: metaid_0000070
parameter: metaid_0000141
reaction: metaid_0000269
reaction: metaid_0000278
reaction: metaid_0000284
species: metaid_0000066
species: metaid_0000061
rule: metaid_0000352
reaction: metaid_0000332
species: metaid_0000077
species: metaid_0000072
parameter: metaid_0000184
species: metaid_0000059
species: metaid_0000088
parameter: metaid_0000134
parameter: metaid_0000158
reaction: metaid_0000233

metaid_0000191
type: Parameter
constant: true
units: metaid_0000324
value: 1.0998

metaid_0000324
type: SBMLUnitsDef
unit: 860213
name: permin

860213
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000213
type: Reaction
is version of: REACT 9481
kinetic law: 860346
name: v1
reactant: 860310
reversible: true
product: 860334
fast: false
is version of: GO:0005154
reactant: 860322
is version of: GO:0048408

860310
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

metaid_0000006
type: Species
notes: 4962 molecules correspond roughly to 50 ng/ml, concentration used throughout the article (MW~6045 Da, vol=1e-12l)
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 4962.0
in compartment: metaid_0000003
name: EGF

metaid_0000003
type: Compartment
is: GO:0005615
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular volume

860334
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000008
type: Species
is version of: REACT 9893
initial concentration: NaN
has version: P00533
boundary condition: false
initial amount: 0.0
constant: false
has only substance units: true
has version: P01133
name: EGF-EGFR
in compartment: metaid_0000005

metaid_0000005
type: Compartment
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm

860322
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000007
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 50000.0
in compartment: metaid_0000003
name: EGFR

metaid_0000335
type: Reaction
kinetic law: 865628
product: 865616
product: 865604
reactant: 865592
fast: false
reversible: true
name: v116

865616
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000070
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2

865604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000014
type: Species
is version of: GO:0030119
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Proti

865592
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

metaid_0000096
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Prot

metaid_0000189
type: Parameter
constant: true
units: metaid_0000324
value: 12.0

metaid_0000137
type: Parameter
constant: true
units: metaid_0000326
value: 3.25581

metaid_0000326
type: SBMLUnitsDef
unit: 860262
unit: 860250
name: peritempermin

860262
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM

860250
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid_0000047
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf-Ras-GTP

metaid_0000327
type: SBMLUnitsDef
unit: 860298
unit: 860286
unit: 860274
name: plperitempermin

860298
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

860286
type: SBMLUnit
exponent: -1.0
scale: 0
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kind: ITEM

860274
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: LITRE

metaid_0000154
type: Parameter
constant: true
units: metaid_0000324
value: 30.0

metaid_0000236
type: Reaction
kinetic law: 861328
product: 861316
reactant: 861304
reactant: 861292
fast: false
reversible: true
name: v24

861316
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

metaid_0000039
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2

861304
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

metaid_0000038
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*

861292
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000027
type: Species
boundary condition: false
is described by: http://identifiers.org/omim/108355
is version of: P62993
constant: false
initial amount: 11000.0
initial concentration: NaN
in compartment: metaid_0000005
name: Grb2
has only substance units: true

metaid_0000203
type: Parameter
constant: true
units: metaid_0000324
value: 960.0

metaid_0000297
type: Reaction
kinetic law: 864217
product: 864205
product: 864193
reactant: 864180
fast: false
reversible: true
name: v85

864205
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000049
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Phosphotase1

864193
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000046
type: Species
is version of: P04049
name: Raf
has only substance units: true
initial amount: 40000.0
boundary condition: false
is described by: http://identifiers.org/omim/164760
constant: false
initial concentration: NaN
in compartment: metaid_0000005

864180
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

metaid_0000078
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi*-P'ase

metaid_0000256
type: Reaction
kinetic law: 862285
product: 862273
reactant: 862261
reactant: 862249
fast: false
reversible: true
name: v44

862273
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000053
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-Raf*

862261
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

metaid_0000050
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf*

862249
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000052
type: Species
in compartment: metaid_0000005
is described by: http://identifiers.org/omim/176872
is version of: Q02750
boundary condition: false
name: MEK
has only substance units: true
initial concentration: NaN
initial amount: 2.2E7
constant: false
is version of: A4QPA9

metaid_0000178
type: Parameter
constant: true
units: metaid_0000326
value: 4.5E-4

metaid_0000271
type: Reaction
kinetic law: 863011
product: 862999
product: 862987
reactant: 862975
fast: false
reversible: true
name: v59

862999
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000065
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0E7
in compartment: metaid_0000005
name: Phosphotase3

862987
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000060
type: Species
is described by: http://identifiers.org/omim/176948
initial amount: 2.1E7
is version of: P28482
boundary condition: false
has only substance units: true
name: ERK
constant: false
initial concentration: NaN
in compartment: metaid_0000005

862975
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

metaid_0000067
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P-P'ase3

metaid_0000019
type: Species
constant: false
is version of: IPR001936
is version of: P20936
boundary condition: false
in compartment: metaid_0000005
has only substance units: true
initial concentration: NaN
initial amount: 12000.0
is described by: http://identifiers.org/omim/139150
name: GAP

metaid_0000126
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

metaid_0000225
type: Reaction
kinetic law: 860816
product: 860804
fast: false
reversible: false
name: v13

860804
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000240
type: Reaction
kinetic law: 861522
product: 861510
reactant: 861498
reactant: 861486
fast: false
reversible: true
name: v28

861510
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

861498
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

861486
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

metaid_0000033
type: Species
has only substance units: true
has part: CHEBI:15996
constant: false
boundary condition: false
in compartment: metaid_0000005
name: Ras-GTP
initial concentration: NaN
initial amount: 0.0
has part: P01112

metaid_0000245
type: Reaction
kinetic law: 861764
product: 861752
product: 861740
reactant: 861728
fast: false
reversible: true
name: v33

861752
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000035
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Grb2-Sos

861740
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000045
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*

861728
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000043
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*-Grb2-Sos

metaid_0000254
type: Reaction
kinetic law: 862188
product: 862176
reactant: 862164
reactant: 862152
fast: false
reversible: true
name: v42

862176
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000051
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf*-P'ase

862164
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

862152
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000211
type: Parameter
constant: true
units: metaid_0000324
value: 0.04002

metaid_0000260
type: Reaction
kinetic law: 862479
product: 862467
reactant: 862455
reactant: 862443
fast: false
reversible: true
name: v48

862467
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000057
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-PP-P'ase2

862455
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000058
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Phosphatase2

862443
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000056
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-PP

metaid_0000309
type: Reaction
kinetic law: 864797
product: 864785
product: 864773
reactant: 864761
fast: false
reversible: true
name: v97

864785
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

metaid_0000082
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-PP

864773
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

metaid_0000088
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-PP

864761
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000087
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P-MEKi-PP

metaid_0000054
type: Species
in compartment: metaid_0000005
is version of: A4QPA9
is version of: Q02750
boundary condition: false
initial amount: 0.0
name: MEK-P
has only substance units: true
is version of: C00562
initial concentration: NaN
constant: false
is described by: http://identifiers.org/omim/176872

metaid_0000042
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP

metaid_0000016
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi^2

metaid_0000083
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-PP-P'ase2i

metaid_0000160
type: Parameter
constant: true
units: metaid_0000324
value: 6.0

metaid_0000149
type: Parameter
constant: true
units: metaid_0000324
value: 3.6

blabla 2
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_Ras_GTP

metaid_0000220
type: Reaction
kinetic law: 860636
product: 860624
reactant: 860612
reactant: 860600
fast: false
reversible: true
name: v8

860624
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000020
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000004
name: EGF-EGFR*^2-GAP

metaid_0000004
type: Compartment
is: GO:0005768
constant: true
size: 4.3E-6
spatial dimensions: 3.0
name: endosomal volume

860612
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

860600
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000010
type: Species
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has version: P00533
constant: false
has version: P01133
initial concentration: NaN
in compartment: metaid_0000005
name: EGF-EGFR*^2
boundary condition: false
initial amount: 0.0
has only substance units: true

metaid_0000336
type: Reaction
kinetic law: 865664
product: 865652
reactant: 865640
fast: false
reversible: true
name: v117

865652
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000071
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos

865640
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000040
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos

metaid_0000018
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000004
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metaid_0000085
type: Species
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has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-MEKi-PP

metaid_0000322
type: SBMLUnitsDef
unit: 860189
name: min

860189
type: SBMLUnit
exponent: 1.0
scale: 0
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kind: SECOND

metaid_0000268
type: Reaction
kinetic law: 862867
product: 862855
reactant: 862843
reactant: 862830
fast: false
reversible: true
name: v56

862855
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

metaid_0000066
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
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name: ERK-PP-P'ase3

862843
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

862830
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

metaid_0000064
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-PP

metaid_0000140
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

metaid_0000283
type: Reaction
kinetic law: 863541
product: 863529
reactant: 863517
reactant: 863505
fast: false
reversible: true
name: v71

863529
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

863517
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000069
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*

863505
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000138
type: Parameter
constant: true
units: metaid_0000324
value: 0.66

metaid_0000164
type: Parameter
constant: true
units: metaid_0000324
value: 33.0

metaid_0000331
type: Reaction
kinetic law: 865448
product: 865436
reactant: 865424
reactant: 865412
fast: false
reversible: true
name: v112

865436
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000095
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP-Prot

865424
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000017
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 81000.0
in compartment: metaid_0000005
name: Prot

865412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000034
type: Species
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boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP

metaid_0000237
type: Reaction
kinetic law: 861376
product: 861364
reactant: 861352
reactant: 861340
fast: false
reversible: true
name: v25

861364
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

861352
type: SpeciesReference
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species: metaid_0000039

861340
type: SpeciesReference
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species: metaid_0000029

metaid_0000029
type: Species
in compartment: metaid_0000005
constant: false
is described by: http://identifiers.org/omim/182530
has only substance units: true
boundary condition: false
name: Sos
initial amount: 26300.0
is version of: Q07889
initial concentration: NaN

metaid_0000257
type: Reaction
kinetic law: 862333
product: 862321
product: 862309
reactant: 862297
fast: false
reversible: true
name: v45

862321
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

862309
type: SpeciesReference
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species: metaid_0000054

862297
type: SpeciesReference
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species: metaid_0000053

metaid_0000266
type: Reaction
kinetic law: 862769
product: 862757
reactant: 862745
reactant: 862732
fast: false
reversible: true
name: v54

862757
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000063
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P-MEK-PP

862745
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

metaid_0000062
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P

862732
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000272
type: Reaction
kinetic law: 863047
product: 863035
reactant: 863023
fast: false
reversible: false
name: v60

863035
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000091
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFRideg

863023
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
is version of: P00533
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFRi

blabla 1
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_Raf*

metaid_0000321
type: SBMLUnitsDef
unit: 860177
name: items

860177
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000320
type: Reaction
kinetic law: 865266
product: 865254
reactant: 865242
fast: false
reversible: true
name: v108

865254
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000025
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GDP

865242
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000032
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP

metaid_0000089
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-PP-P'ase3i

metaid_0000172
type: Parameter
constant: true
units: metaid_0000324
value: 6.0

metaid_0000232
type: Reaction
kinetic law: 861148
product: 861135
reactant: 861123
reactant: 861111
fast: false
reversible: true
name: v20

861135
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

861123
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000048
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Ras-GTP*

861111
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000030
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos

metaid_0000073
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GTP

metaid_0000152
type: Parameter
constant: true
units: metaid_0000326
value: 0.0015

metaid_0000295
type: Reaction
kinetic law: 864120
product: 864108
reactant: 864096
reactant: 864084
fast: false
reversible: true
name: v83

864108
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

864096
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

864084
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000221
type: Reaction
kinetic law: 860672
product: 860660
reactant: 860648
fast: false
reversible: false
name: v9

860660
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

metaid_0000023
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2

860648
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000028
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2

metaid_0000343
type: Reaction
kinetic law: 865976
product: 865964
reactant: 865952
reactant: 865940
fast: false
reversible: true
name: v124

865964
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000099

metaid_0000099
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot

865952
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000305
type: Reaction
kinetic law: 864603
product: 864591
product: 864579
reactant: 864567
fast: false
reversible: true
name: v93

864591
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

864579
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

864567
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000084

metaid_0000084
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P-P'ase2i

metaid_0000141
type: Parameter
constant: true
units: metaid_0000324
value: 0.6

metaid_0000269
type: Reaction
kinetic law: 862915
product: 862903
product: 862891
reactant: 862879
fast: false
reversible: true
name: v57

862903
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

862891
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

862879
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

metaid_0000278
type: Reaction
kinetic law: 863313
product: 863301
product: 863289
reactant: 863277
fast: false
reversible: true
name: v66

863301
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000024
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos

863289
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000074
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rasi-GTP

863277
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000284
type: Reaction
kinetic law: 863589
product: 863577
reactant: 863565
reactant: 863553
fast: false
reversible: true
name: v72

863577
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

863565
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

863553
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000061
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-MEK-PP

metaid_0000332
type: Reaction
kinetic law: 865496
product: 865484
product: 865472
reactant: 865460
fast: false
reversible: true
name: v113

865484
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000026
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GTP

865472
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

865460
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000077
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi*

metaid_0000072
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GDP

metaid_0000184
type: Parameter
constant: true
units: metaid_0000326
value: 0.003

metaid_0000059
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-P-P'ase2

metaid_0000134
type: Parameter
constant: true
units: metaid_0000324
value: 0.003

metaid_0000158
type: Parameter
constant: true
units: metaid_0000326
value: 2.2E-5

metaid_0000233
type: Reaction
kinetic law: 861196
product: 861184
product: 861172
reactant: 861160
fast: false
reversible: true
name: v21

861184
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000031
type: Species
initial amount: 72000.0
has part: CHEBI:17552
name: Ras-GDP
has only substance units: true
constant: false
boundary condition: false
initial concentration: NaN
has part: P01112
in compartment: metaid_0000005

861172
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

861160
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000242
type: Reaction
kinetic law: 861618
product: 861606
reactant: 861594
reactant: 861582
fast: false
reversible: true
name: v30

861606
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

861594
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

861582
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000317
type: Reaction
kinetic law: 865134
product: 865122
reactant: 865110
fast: false
reversible: true
name: v105

865122
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

865110
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000153
type: Parameter
constant: true
units: metaid_0000326
value: 1.0E-5

metaid_0000296
type: Reaction
kinetic law: 864168
product: 864156
reactant: 864144
reactant: 864132
fast: false
reversible: true
name: v84

864156
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

864144
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

864132
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000344
type: Reaction
kinetic law: 866024
product: 866012
product: 866000
reactant: 865988
fast: false
reversible: true
name: v125

866012
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

866000
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

865988
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000099

metaid_0000196
type: Parameter
constant: true
units: metaid_0000326
value: 0.00143

metaid_0000306
type: Reaction
kinetic law: 864651
product: 864639
reactant: 864627
reactant: 864615
fast: false
reversible: true
name: v94

864639
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

864627
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

864615
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000097
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Prot

metaid_0000218
type: Reaction
kinetic law: 860551
product: 860539
reactant: 860527
is version of: GO:0031623
fast: false
reversible: true
name: v6

860539
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

860527
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000198
type: Parameter
constant: true
units: metaid_0000324
value: 30.0

metaid_0000291
type: Reaction
kinetic law: 863927
product: 863915
product: 863903
reactant: 863891
fast: false
reversible: true
name: v79

863915
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

863903
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000022
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP

863891
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000146
type: Parameter
constant: true
units: metaid_0000324
value: 600000.0

metaid_0000301
type: Reaction
kinetic law: 864411
product: 864399
product: 864387
reactant: 864374
fast: false
reversible: true
name: v89

864399
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

864387
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

864374
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000081

metaid_0000081
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P-Rafi*

metaid_0000280
type: Reaction
kinetic law: 863409
product: 863397
product: 863385
reactant: 863373
fast: false
reversible: true
name: v68

863397
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

863385
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

863373
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000329
type: Reaction
kinetic law: 865363
product: 865351
product: 865339
reactant: 865327
fast: false
reversible: true
name: v110

865351
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

865339
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

865327
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000094
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP-Prot

metaid_0000161
type: Parameter
constant: true
units: metaid_0000324
value: 360.0

metaid_0000208
type: Parameter
constant: true
units: metaid_0000324
value: 30.0

metaid_0000015
type: Species
in compartment: metaid_0000005
initial amount: 0.0
initial concentration: NaN
boundary condition: false
has version: P00533
has only substance units: true
name: EGF-EGFRi
has version: P01133
constant: false

metaid_0000180
type: Parameter
constant: true
units: metaid_0000325
value: 61200.0

metaid_0000325
type: SBMLUnitsDef
unit: 860237
unit: 860225
name: itemspermin

860237
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

860225
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

metaid_0000318
type: Reaction
kinetic law: 865182
product: 865170
reactant: 865158
reactant: 865146
fast: false
reversible: true
name: v106

865170
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000093
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Prot

865158
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865146
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000313
type: Reaction
kinetic law: 864990
product: 864978
product: 864966
reactant: 864954
is described by: http://identifiers.org/omim/164760
fast: false
reversible: true
name: v101

864978
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

864966
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

864954
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000090

metaid_0000090
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P-P'ase3i

metaid_0000143
type: Parameter
constant: true
units: metaid_0000325
value: 130.2

metaid_0000286
type: Reaction
kinetic law: 863686
product: 863674
product: 863662
reactant: 863650
fast: false
reversible: true
name: v74

863674
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

863662
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

863650
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

metaid_0000219
type: Reaction
kinetic law: 860588
product: 860575
reactant: 860563
is version of: GO:0031623
fast: false
reversible: false
name: v7

860575
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000013
type: Species
initial concentration: NaN
has version: P00533
has version: P01133
name: EGF-EGFRi*^2
initial amount: 0.0
constant: false
boundary condition: false
in compartment: metaid_0000005
has only substance units: true

860563
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000292
type: Reaction
kinetic law: 863975
product: 863963
product: 863951
reactant: 863939
fast: false
reversible: true
name: v80

863963
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

863951
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

863939
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000167
type: Parameter
constant: true
units: metaid_0000326
value: 1.0E-4

metaid_0000173
type: Parameter
constant: true
units: metaid_0000324
value: 12.0

metaid_0000302
type: Reaction
kinetic law: 864458
product: 864446
reactant: 864435
reactant: 864423
fast: false
reversible: true
name: v90

864446
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

864435
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

864423
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

metaid_0000192
type: Parameter
constant: true
units: metaid_0000326
value: 0.00111

W3 CDTF: Mon Aug 15 07:36:38 BST 2005

metaid_0000132
type: Parameter
constant: true
units: metaid_0000324
value: 0.003

metaid_0000214
type: Reaction
fast: false
reversible: true
kinetic law: 860382
reactant: 860358
is version of: REACT 9397
is version of: GO:0046983
is version of: GO:0007171
product: 860370
name: v2

860358
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000008

860370
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000009
type: Species
is version of: REACT 9820
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000005
has only substance units: true
initial amount: 0.0
name: EGF-EGFR^2
constant: false
has version: P00533
has version: P01133

metaid_0000275
type: Reaction
kinetic law: 863167
product: 863155
reactant: 863143
reactant: 863131
fast: false
reversible: true
name: v63

863155
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

863143
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

863131
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000209
type: Parameter
constant: true
units: metaid_0000326
value: 5.0E-4

metaid_0000181
type: Parameter
constant: true
units: metaid_0000321
value: 2.0E14

metaid_0000155
type: Parameter
constant: true
units: metaid_0000324
value: 24.0

metaid_0000204
type: Parameter
constant: true
units: metaid_0000324
value: 342.0

metaid_0000041
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP

metaid_0000298
type: Reaction
kinetic law: 864265
product: 864253
reactant: 864241
reactant: 864229
fast: false
reversible: true
name: v86

864253
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000079
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-Rafi*

864241
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

864229
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

metaid_0000127
type: Parameter
constant: true
units: metaid_0000324
value: 60.0

blabla 6
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_EGF_EGFR*

metaid_0000185
type: Parameter
constant: true
units: metaid_0000324
value: 3.84

metaid_0000314
type: Reaction
kinetic law: 865026
product: 865014
reactant: 865002
fast: false
reversible: true
name: v102

865014
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

865002
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000144
type: Parameter
constant: true
units: metaid_0000326
value: 1.0E-4

metaid_0000226
type: Reaction
kinetic law: 860865
product: 860853
reactant: 860841
reactant: 860829
fast: false
reversible: true
name: v14

860853
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

860841
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

860829
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000287
type: Reaction
kinetic law: 863734
product: 863722
reactant: 863710
reactant: 863698
fast: false
reversible: true
name: v75

863722
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000075
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi-Rasi-GTP

863710
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

863698
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

metaid_0000241
type: Reaction
kinetic law: 861570
product: 861558
product: 861546
reactant: 861534
fast: false
reversible: true
name: v29

861558
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

861546
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

861534
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000246
type: Reaction
kinetic law: 861813
product: 861801
product: 861789
reactant: 861777
fast: false
reversible: true
name: v34

861801
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

861789
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

861777
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000212
type: Parameter
constant: true
units: metaid_0000324
value: 0.01002

metaid_0000168
type: Parameter
constant: true
units: metaid_0000324
value: 0.318

metaid_0000261
type: Reaction
kinetic law: 862527
product: 862515
product: 862503
reactant: 862491
fast: false
reversible: true
name: v49

862515
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

862503
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

862491
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000193
type: Parameter
constant: true
units: metaid_0000324
value: 210.0

metaid_0000215
type: Reaction
name: v3
is version of: GO:0046777
product: 860406
reactant: 860394
is version of: REACT 9388
reversible: true
is version of: GO:0004713
is version of: GO:0007171
fast: false
kinetic law: 860418

860406
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

860394
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000337
type: Reaction
kinetic law: 865712
product: 865700
reactant: 865688
reactant: 865676
fast: false
reversible: true
name: v118

865700
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

865688
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865676
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

W3 CDTF: Tue May 17 17:40:56 BST 2011

blabla 5
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_SHC_P_t

metaid_0000201
type: Parameter
constant: true
units: metaid_0000326
value: 0.00534

metaid_0000250
type: Reaction
kinetic law: 861994
product: 861982
reactant: 861970
reactant: 861958
fast: false
reversible: true
name: v38

861982
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000044
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*-Grb2

861970
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

861958
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000197
type: Parameter
constant: true
units: metaid_0000324
value: 3.48

metaid_0000139
type: Parameter
constant: true
units: metaid_0000324
value: 6.0

metaid_0000156
type: Parameter
constant: true
units: metaid_0000326
value: 2.1E-4

metaid_0000238
type: Reaction
kinetic law: 861425
product: 861413
reactant: 861400
reactant: 861388
fast: false
reversible: true
name: v26

861413
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

861400
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

861388
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000205
type: Parameter
constant: true
units: metaid_0000324
value: 36.0

metaid_0000299
type: Reaction
kinetic law: 864313
product: 864301
product: 864289
reactant: 864277
fast: false
reversible: true
name: v87

864301
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

864289
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

metaid_0000080
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P

864277
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000258
type: Reaction
kinetic law: 862381
product: 862369
reactant: 862357
reactant: 862345
fast: false
reversible: true
name: v46

862369
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

metaid_0000055
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-P-Raf*

862357
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

862345
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

metaid_0000130
type: Parameter
constant: true
units: metaid_0000324
value: 0.0996

metaid_0000273
type: Reaction
kinetic law: 863083
product: 863071
reactant: 863059
fast: false
reversible: false
name: v61

863071
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

863059
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000021
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFi

metaid_0000128
type: Parameter
constant: true
units: metaid_0000324
value: 0.6

metaid_0000227
type: Reaction
kinetic law: 860902
product: 860890
reactant: 860877
fast: false
reversible: false
name: v15

860890
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

860877
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

metaid_0000247
type: Reaction
kinetic law: 861861
product: 861849
product: 861837
reactant: 861825
fast: false
reversible: true
name: v35

861849
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

861837
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

861825
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000262
type: Reaction
kinetic law: 862575
product: 862563
reactant: 862551
reactant: 862539
fast: false
reversible: true
name: v50

862563
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

862551
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

862539
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000123
type: Parameter
constant: true
units: metaid_0000326
value: 0.003

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000076
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rasi-GTP*

metaid_0000310
type: Reaction
kinetic law: 864846
product: 864834
reactant: 864821
reactant: 864809
fast: false
reversible: true
name: v98

864834
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

864821
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

864809
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

blabla 4
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_ERK_PP

metaid_0000222
type: Reaction
kinetic law: 860720
product: 860708
reactant: 860696
reactant: 860684
is version of: GO:0031623
fast: false
reversible: true
name: v10

860708
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

860696
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

860684
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000338
type: Reaction
kinetic law: 865760
product: 865748
product: 865736
reactant: 865724
fast: false
reversible: true
name: v119

865748
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

865736
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

865724
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

metaid_0000142
type: Parameter
constant: true
units: metaid_0000324
value: 60.0

metaid_0000285
type: Reaction
kinetic law: 863638
product: 863625
reactant: 863613
reactant: 863601
fast: false
reversible: true
name: v73

863625
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

863613
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

863601
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000333
type: Reaction
kinetic law: 865532
product: 865520
reactant: 865508
fast: false
reversible: true
name: v114

865520
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

865508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

metaid_0000239
type: Reaction
kinetic law: 861474
product: 861461
product: 861449
reactant: 861437
fast: false
reversible: true
name: v27

861461
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

861449
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

861437
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000187
type: Parameter
constant: true
units: metaid_0000326
value: 0.003

metaid_0000259
type: Reaction
kinetic law: 862431
product: 862419
product: 862406
reactant: 862394
fast: false
reversible: true
name: v47

862419
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

862406
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

862394
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

metaid_0000131
type: Parameter
constant: false
units: metaid_0000324
value: NaN

metaid_0000274
type: Reaction
kinetic law: 863119
product: 863107
reactant: 863095
fast: false
reversible: false
name: v62

863107
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000092

metaid_0000092
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2deg

863095
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

blabla 3
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_MEK_PP

metaid_0000135
type: Parameter
constant: true
units: metaid_0000326
value: 1.0E-4

metaid_0000159
type: Parameter
constant: true
units: metaid_0000326
value: 0.0021

metaid_0000234
type: Reaction
kinetic law: 861244
product: 861232
reactant: 861220
reactant: 861208
fast: false
reversible: true
name: v22

861232
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000037
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc

861220
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

861208
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

metaid_0000036
type: Species
initial concentration: NaN
is described by: http://identifiers.org/omim/605217
name: Shc
in compartment: metaid_0000005
has only substance units: true
is version of: P98077
boundary condition: false
initial amount: 101000.0
constant: false

metaid_0000176
type: Parameter
constant: true
units: metaid_0000326
value: 4.5E-4

metaid_0000124
type: Parameter
constant: true
units: metaid_0000324
value: 0.228

metaid_0000223
type: Reaction
kinetic law: 860756
product: 860744
reactant: 860732
fast: false
reversible: true
name: v11

860744
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

860732
type: SpeciesReference
stoichiometry: 2.0
species: metaid_0000015

metaid_0000243
type: Reaction
kinetic law: 861667
product: 861655
product: 861643
reactant: 861631
fast: false
reversible: true
name: v31

861655
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

861643
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

861631
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000307
type: Reaction
kinetic law: 864700
product: 864688
product: 864675
reactant: 864663
fast: false
reversible: true
name: v95

864688
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

864675
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

metaid_0000086
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P

864663
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000199
type: Parameter
constant: true
units: metaid_0000326
value: 2.5E-5

metaid_0000147
type: Parameter
constant: true
units: metaid_0000324
value: 16.5

metaid_0000068
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc

metaid_0000334
type: Reaction
kinetic law: 865580
product: 865568
reactant: 865556
reactant: 865544
fast: false
reversible: true
name: v115

865568
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

865556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865544
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

metaid_0000188
type: Parameter
constant: true
units: metaid_0000326
value: 0.0071

metaid_0000281
type: Reaction
kinetic law: 863457
product: 863445
reactant: 863433
reactant: 863421
fast: false
reversible: true
name: v69

863445
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

863433
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

863421
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

metaid_0000136
type: Parameter
constant: true
units: metaid_0000324
value: 12.0

metaid_0000162
type: Parameter
constant: true
units: metaid_0000324
value: 36.0

metaid_0000235
type: Reaction
kinetic law: 861280
product: 861268
reactant: 861256
fast: false
reversible: true
name: v23

861268
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

861256
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000255
type: Reaction
kinetic law: 862237
product: 862224
product: 862212
reactant: 862200
fast: false
reversible: true
name: v43

862224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

862212
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

862200
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000264
type: Reaction
kinetic law: 862671
product: 862659
reactant: 862647
reactant: 862635
fast: false
reversible: true
name: v52

862659
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

862647
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

862635
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000319
type: Reaction
kinetic law: 865230
product: 865218
product: 865206
reactant: 865194
fast: false
reversible: true
name: v107

865218
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

865206
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

865194
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000270
type: Reaction
kinetic law: 862963
product: 862951
reactant: 862939
reactant: 862927
fast: false
reversible: true
name: v58

862951
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

862939
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

862927
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

ORG:
  orgname: MIT
n:
  given: Birgit
  family: Schoeberl

metaid_0000170
type: Parameter
constant: true
units: metaid_0000326
value: 7.0E-5

metaid_0000323
type: SBMLUnitsDef
unit: 860201
name: pl

860201
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: LITRE

metaid_0000253
type: Reaction
kinetic law: 862140
product: 862128
reactant: 862116
reactant: 862103
fast: false
reversible: true
name: v41

862128
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

862116
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

862103
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000308
type: Reaction
kinetic law: 864749
product: 864737
reactant: 864724
reactant: 864712
fast: false
reversible: true
name: v96

864737
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

864724
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

864712
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

metaid_0000150
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

metaid_0000293
type: Reaction
kinetic law: 864023
product: 864011
product: 863999
reactant: 863987
fast: false
reversible: true
name: v81

864011
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

863999
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

863987
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000148
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

metaid_0000174
type: Parameter
constant: true
units: metaid_0000326
value: 0.0021

metaid_0000341
type: Reaction
kinetic law: 865892
product: 865880
product: 865868
reactant: 865856
fast: false
reversible: true
name: v122

865880
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

865868
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

865856
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

metaid_0000098
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot

metaid_0000303
type: Reaction
kinetic law: 864507
product: 864495
product: 864482
reactant: 864470
fast: false
reversible: true
name: v91

864495
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

864482
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

864470
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

metaid_0000133
type: Parameter
constant: true
units: metaid_0000324
value: 0.3

metaid_0000267
type: Reaction
kinetic law: 862817
product: 862805
product: 862793
reactant: 862781
fast: false
reversible: true
name: v55

862805
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

862793
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

862781
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000276
type: Reaction
kinetic law: 863216
product: 863204
reactant: 863192
reactant: 863180
fast: false
reversible: true
name: v64

863204
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

863192
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

863180
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000282
type: Reaction
kinetic law: 863493
product: 863481
reactant: 863469
fast: false
reversible: true
name: v70

863481
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

863469
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

metaid_0000330
type: Reaction
kinetic law: 865400
product: 865388
reactant: 865376
fast: false
reversible: true
name: v111

865388
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

865376
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000163
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

metaid_0000012
type: Species
boundary condition: false
initial concentration: NaN
has only substance units: true
has version: GO:0030119
has version: P00533
name: EGF-EGFR*^2-GAP-Grb2-Prot
has version: P20936
initial amount: 0.0
in compartment: metaid_0000005
constant: false
has version: P62993
has version: P01133

metaid_0000182
type: Parameter
constant: true
units: metaid_0000324
value: 18.0

metaid_0000265
type: Reaction
kinetic law: 862719
product: 862707
product: 862695
reactant: 862683
fast: false
reversible: true
name: v53

862707
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

862695
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

862683
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

metaid_0000171
type: Parameter
constant: true
units: metaid_0000326
value: 2.4E-5

metaid_0000231
type: Reaction
kinetic law: 861099
product: 861087
product: 861074
reactant: 861061
fast: false
reversible: true
name: v19

861087
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

861074
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

861061
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000186
type: Parameter
constant: true
units: metaid_0000324
value: 2.574

metaid_0000315
type: Reaction
kinetic law: 865062
product: 865050
reactant: 865038
fast: false
reversible: true
name: v103

865050
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

865038
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000145
type: Parameter
constant: true
units: metaid_0000324
value: 12.0

metaid_0000288
type: Reaction
kinetic law: 863782
product: 863770
product: 863758
reactant: 863746
fast: false
reversible: true
name: v76

863770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

863758
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

863746
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000279
type: Reaction
kinetic law: 863361
product: 863349
reactant: 863337
reactant: 863325
fast: false
reversible: true
name: v67

863349
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

863337
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

863325
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000151
type: Parameter
constant: true
units: metaid_0000324
value: 78.0

metaid_0000294
type: Reaction
kinetic law: 864072
product: 864059
product: 864047
reactant: 864035
fast: false
reversible: true
name: v82

864059
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

864047
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

864035
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000351
type: Parameter
constant: false
value: NaN
name: C_internalization

metaid_0000169
type: Parameter
constant: true
units: metaid_0000324
value: 60.0

metaid_0000342
type: Reaction
kinetic law: 865928
product: 865916
reactant: 865904
fast: false
reversible: true
name: v123

865916
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

865904
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000175
type: Parameter
constant: true
units: metaid_0000324
value: 1.8

metaid_0000194
type: Parameter
constant: true
units: metaid_0000324
value: 174.0

metaid_0000304
type: Reaction
kinetic law: 864555
product: 864543
reactant: 864531
reactant: 864519
fast: false
reversible: true
name: v92

864543
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000084

864531
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

864519
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000216
type: Reaction
kinetic law: 860467
product: 860455
reactant: 860443
reactant: 860430
fast: false
reversible: true
name: v4

860455
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

860443
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

860430
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000277
type: Reaction
kinetic law: 863265
product: 863253
reactant: 863241
reactant: 863229
fast: false
reversible: true
name: v65

863253
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

863241
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

863229
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000202
type: Parameter
constant: true
units: metaid_0000324
value: 1.98

metaid_0000251
type: Reaction
kinetic law: 862043
product: 862030
product: 862018
reactant: 862006
fast: false
reversible: true
name: v39

862030
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

862018
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

862006
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

metaid_0000183
type: Parameter
constant: true
units: metaid_0000326
value: 9.0E-5

metaid_0000157
type: Parameter
constant: true
units: metaid_0000324
value: 1.38

metaid_0000206
type: Parameter
constant: true
units: metaid_0000326
value: 0.00145

metaid_0000129
type: Parameter
constant: true
units: metaid_0000326
value: 1.038E-5

metaid_0000316
type: Reaction
kinetic law: 865098
product: 865086
reactant: 865074
fast: false
reversible: true
name: v104

865086
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

865074
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

metaid_0000228
type: Reaction
kinetic law: 860952
product: 860940
reactant: 860928
reactant: 860915
fast: false
reversible: true
name: v16

860940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

860928
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

860915
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000289
type: Reaction
kinetic law: 863831
product: 863819
reactant: 863807
reactant: 863795
fast: false
reversible: true
name: v77

863819
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

863807
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

863795
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000248
type: Reaction
kinetic law: 861898
product: 861886
reactant: 861874
fast: false
reversible: false
name: v36

861886
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

861874
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000263
type: Reaction
kinetic law: 862623
product: 862611
product: 862599
reactant: 862587
fast: false
reversible: true
name: v51

862611
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

862599
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000052

862587
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000311
type: Reaction
kinetic law: 864894
product: 864882
product: 864870
reactant: 864858
fast: false
reversible: true
name: v99

864882
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

864870
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

864858
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

metaid_0000195
type: Parameter
constant: true
units: metaid_0000324
value: 48.0

metaid_0000217
type: Reaction
kinetic law: 860515
product: 860503
product: 860491
reactant: 860479
fast: false
reversible: true
name: v5

860503
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

860491
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

860479
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000290
type: Reaction
kinetic law: 863879
product: 863867
product: 863855
reactant: 863843
fast: false
reversible: true
name: v78

863867
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

863855
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

863843
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

metaid_0000339
type: Reaction
kinetic law: 865796
product: 865784
reactant: 865772
fast: false
reversible: true
name: v120

865784
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

865772
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000165
type: Parameter
constant: true
units: metaid_0000324
value: 1.284

metaid_0000252
type: Reaction
kinetic law: 862091
product: 862079
reactant: 862067
reactant: 862055
fast: false
reversible: true
name: v40

862079
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

862067
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

862055
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000190
type: Parameter
constant: true
units: metaid_0000324
value: 60.0

metaid_0000300
type: Reaction
kinetic law: 864361
product: 864349
reactant: 864337
reactant: 864325
fast: false
reversible: true
name: v88

864349
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000081

864337
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

864325
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000340
type: Reaction
kinetic law: 865844
product: 865832
reactant: 865820
reactant: 865808
fast: false
reversible: true
name: v121

865832
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

865820
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865808
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000328
type: Reaction
kinetic law: 865314
product: 865302
reactant: 865290
reactant: 865278
fast: false
reversible: true
name: v109

865302
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

865290
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

865278
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000207
type: Parameter
constant: true
units: metaid_0000324
value: 16.2

ORG:
  orgname: Mt. Sinai Hospital/ Univ. of Toronto
n:
  given: Ken
  family: Lau

metaid_0000353
type: Parameter
constant: true
units: metaid_0000321
value: 50000.0
name: total_Receptors

metaid_0000229
type: Reaction
kinetic law: 861000
product: 860988
reactant: 860976
reactant: 860964
fast: false
reversible: true
name: v17

860988
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

860976
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

860964
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000249
type: Reaction
kinetic law: 861946
product: 861934
product: 861922
reactant: 861910
fast: false
reversible: true
name: v37

861934
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

861922
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

861910
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

metaid_0000177
type: Parameter
constant: true
units: metaid_0000324
value: 0.09

metaid_0000125
type: Parameter
constant: true
units: metaid_0000324
value: 6.0

metaid_0000312
type: Reaction
kinetic law: 864942
product: 864930
reactant: 864918
reactant: 864906
is described by: http://identifiers.org/omim/164760
fast: false
reversible: true
name: v100

864930
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000090

864918
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

864906
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000224
type: Reaction
kinetic law: 860792
product: 860780
reactant: 860768
fast: false
reversible: true
name: v12

860780
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

860768
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000230
type: Reaction
kinetic law: 861049
product: 861037
reactant: 861025
reactant: 861012
fast: false
reversible: true
name: v18

861037
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

861025
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

861012
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000244
type: Reaction
kinetic law: 861715
product: 861703
product: 861691
reactant: 861679
fast: false
reversible: true
name: v32

861703
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

861691
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

861679
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000210
type: Parameter
constant: true
units: metaid_0000324
value: 18.0

metaid_0000166
type: Parameter
constant: true
units: metaid_0000326
value: 0.001

ORG:
  orgname: University of Vienna
n:
  given: Rainer
  family: Machne