BIOMD0000000018
type: SBMLModel
reaction: 991516
species: 990554
reaction: 991758
reaction: 991242
compartment: 990318
reaction: 992016
reaction: 991149
name: Morrison1989_FolateCycle
notes: This is a folate model that includes folate polyglutamation. Morrison and Allegra, JBC:264,10552-10566 (1989) Folate cycle kinetics in breast cancer cells Note: two flow BCs were converted into two downstream concentration BCs, thus removing the GAR and dUMP state variables. This dropped the number of ODEs from 21 to 19. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 991269
reaction: 991204
reaction: 991099
area units: area
species: 990635
species: 990534
units def: metaid_0000085
reaction: 991614
reaction: 991398
reaction: 991302
species: 990795
species: 990755
reaction: 991878
reaction: 991738
reaction: 991718
species: 990915
reaction: 991858
species: 990515
species: 990375
length unit: length
curated: true
reaction: 991675
reaction: 991655
reaction: 991635
reaction: 991896
volume units: metaid_0000029
species: 990655
species: 990895
species: 990615
species: 990834
reaction: 991594
reaction: 991380
time units: metaid_0000086
species: 990775
reaction: 991456
is described by: http://identifiers.org/pubmed/2732237
reaction: 991698
rule: metaid_0000089
reaction: 991838
reaction: 991818
reaction: 991798
reaction: 991130
reaction: 991346
reaction: 991778
reaction: 991078
species: 990355
reaction: 991058
species: 990455
is: C50
reaction: 991017
species: 990694
rule: metaid_0000088
species: 990854
reaction: 991437
reaction: 991417
is: MODEL6617317313
reaction: 991936
reaction: 991916
species: 990974
species: 990714
species: 990495
parameter: metaid_0000087
is version of: GO:0046655
compartment: 990332
species: 990574
reaction: 991577
occurs in: http://identifiers.org/taxonomy/9606
reaction: 991557
species: 990475
reaction: 991170

991516
type: Reaction
kinetic law: 616185
product: 616173
reactant: 616161
is: http://identifiers.org/ec-code/3.4.19.9
fast: false
reversible: false

616197
type: LocalParameter
value: 0.031

616173
type: SpeciesReference
stoichiometry: 1.0
species: 990635

990635
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

990318
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0

616161
type: SpeciesReference
stoichiometry: 1.0
species: 990655

990655
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

990554
type: Species
is: C04376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 16.49
initial amount: NaN
in compartment: 990318

991758
type: Reaction
kinetic law: 616776
product: 616764
reactant: 616752
reactant: 616740
fast: false
reversible: false

616788
type: LocalParameter
value: 314000.0

616764
type: SpeciesReference
stoichiometry: 1.0
species: 990775

990775
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

616752
type: SpeciesReference
stoichiometry: 1.0
species: 990394

990394
type: Species
is: P00374
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.64
initial amount: NaN
in compartment: 990318
name: dihydrofolate reductase free

616740
type: SpeciesReference
stoichiometry: 1.0
species: 990674

990674
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

991242
type: Reaction
has part: http://identifiers.org/ec-code/6.3.4.3
reactant: 615113
kinetic law: 615137
fast: false
reversible: false
has part: http://identifiers.org/ec-code/1.5.1.5
has part: R01655
product: 615125
has part: R01220
reactant: 615101

615113
type: SpeciesReference
stoichiometry: 1.0
species: 990955

990955
type: Species
is: C00006
is: CHEBI:18009
constant: false
boundary condition: true
has only substance units: false
initial concentration: 6.73
initial amount: NaN
in compartment: 990318

615173
type: LocalParameter
value: 21.8

615161
type: LocalParameter
value: 3.0

615149
type: LocalParameter
value: 68500.0

615125
type: SpeciesReference
stoichiometry: 1.0
species: 990495

990495
type: Species
in compartment: 990318
name: 10-formyl-tetrahydrofolate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00234
constant: false
is: CHEBI:15637

615101
type: SpeciesReference
stoichiometry: 1.0
species: 990455

990455
type: Species
is: CHEBI:15636
initial concentration: 0.26
initial amount: NaN
name: 5,10-methylene-tetrahydrofolate
constant: false
has only substance units: false
in compartment: 990318
is: C00143
boundary condition: false

992016
type: Reaction
kinetic law: 617472
product: 617460
reactant: 617448
fast: false
reversible: false

617484
type: LocalParameter
value: 0.03

617460
type: SpeciesReference
stoichiometry: 1.0
species: 990674

617448
type: SpeciesReference
stoichiometry: 1.0
species: 990775

991149
type: Reaction
reversible: false
kinetic law: 614509
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
product: 614497
is: R00943
reactant: 614485
reactant: 614473
reactant: 614461

614557
type: LocalParameter
value: 1600.0

614545
type: LocalParameter
value: 56.0

614533
type: LocalParameter
value: 230.0

614521
type: LocalParameter
value: 3600.0

614497
type: SpeciesReference
stoichiometry: 1.0
species: 990495

614485
type: SpeciesReference
stoichiometry: 1.0
species: 990895

990895
type: Species
is: C00002
is: CHEBI:15422
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2980.0
initial amount: NaN
in compartment: 990318

614473
type: SpeciesReference
stoichiometry: 1.0
species: 990874

990874
type: Species
is: C00058
is: CHEBI:15740
constant: false
boundary condition: true
has only substance units: false
initial concentration: 500.0
initial amount: NaN
in compartment: 990318

614461
type: SpeciesReference
stoichiometry: 1.0
species: 990435

990435
type: Species
is: C00101
initial concentration: 0.46
has only substance units: false
name: tetrahydrofolate
boundary condition: false
constant: false
in compartment: 990318
is: CHEBI:20506
initial amount: NaN

991269
type: Reaction
modifier: 615281
reactant: 615197
is: R02101
is version of: http://identifiers.org/ec-code/2.1.1.45
reactant: 615185
product: 615209
kinetic law: 615305
modifier: 615233
modifier: 615257
modifier: 615221
modifier: 615245
reversible: false
modifier: 615270
modifier: 615293
fast: false

615197
type: SpeciesReference
stoichiometry: 1.0
species: 990815

990815
type: Species
is: C00365
is: CHEBI:17622
constant: false
boundary condition: true
has only substance units: false
initial concentration: 20.76
initial amount: NaN
in compartment: 990318

615185
type: SpeciesReference
stoichiometry: 1.0
species: 990455

615209
type: SpeciesReference
stoichiometry: 1.0
species: 990355

990355
type: Species
constant: false
is version of: C00415
is version of: CHEBI:15633
initial amount: NaN
initial concentration: 0.0012
in compartment: 990318
name: dihydrofolate free
boundary condition: false
has only substance units: false

615426
type: LocalParameter
value: 0.047

615317
type: LocalParameter
value: 58.0

615353
type: LocalParameter
value: 3.0

615402
type: LocalParameter
value: 0.07

615366
type: LocalParameter
value: 1.6

615390
type: LocalParameter
value: 0.08

615329
type: LocalParameter
value: 2.5

615414
type: LocalParameter
value: 0.065

615378
type: LocalParameter
value: 13.0

615341
type: LocalParameter
value: 1.8

990515
type: Species
name: 10-formyl-dihydrofolate
is: CHEBI:15634
initial concentration: 3.32E-4
has only substance units: false
initial amount: NaN
in compartment: 990318
boundary condition: false
constant: false
is: C03204

990615
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

990595
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

991204
type: Reaction
modifier: 614945
reversible: false
kinetic law: 614969
is: R04560
is version of: http://identifiers.org/ec-code/2.1.2.3
product: 614873
modifier: 614897
reactant: 614861
reactant: 614849
fast: false
modifier: 614933
modifier: 614909
modifier: 614957
modifier: 614885
modifier: 614921
is: REACT 812

615053
type: LocalParameter
value: 31.5

615065
type: LocalParameter
value: 2.33

614993
type: LocalParameter
value: 5.5

615077
type: LocalParameter
value: 3.61

615005
type: LocalParameter
value: 24.0

615089
type: LocalParameter
value: 5.89

615017
type: LocalParameter
value: 2.89

615029
type: LocalParameter
value: 5.3

615041
type: LocalParameter
value: 40.0

614981
type: LocalParameter
value: 31675.0

614873
type: SpeciesReference
stoichiometry: 1.0
species: 990435

614861
type: SpeciesReference
stoichiometry: 1.0
species: 990574

990574
type: Species
is: C04677
is: CHEBI:18406
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.695
initial amount: NaN
in compartment: 990318

614849
type: SpeciesReference
stoichiometry: 1.0
species: 990495

991099
type: Reaction
fast: false
modifier: 614207
modifier: 614243
reversible: false
modifier: 614195
product: 614170
modifier: 614219
modifier: 614231
kinetic law: 614255
is version of: http://identifiers.org/ec-code/1.5.1.20
reactant: 614146
reactant: 614158
is: R01224
modifier: 614183

614170
type: SpeciesReference
stoichiometry: 1.0
species: 990475

990475
type: Species
is: CHEBI:15641
has only substance units: false
is: C00440
initial amount: NaN
constant: false
initial concentration: 1.63
in compartment: 990318
boundary condition: false
name: 5-methyl-tetrahydrofolate

614315
type: LocalParameter
value: 59.0

614339
type: LocalParameter
value: 7.68

614267
type: LocalParameter
value: 224.8

614327
type: LocalParameter
value: 21.3

614303
type: LocalParameter
value: 0.4

614351
type: LocalParameter
value: 2.77

614291
type: LocalParameter
value: 50.0

614363
type: LocalParameter
value: 1.0

614279
type: LocalParameter
value: 50.0

614146
type: SpeciesReference
stoichiometry: 1.0
species: 990455

614158
type: SpeciesReference
stoichiometry: 1.0
species: 990974

990974
type: Species
is: C00005
is: CHEBI:16474
constant: false
boundary condition: true
has only substance units: false
initial concentration: 294.0
initial amount: NaN
in compartment: 990318

990534
type: Species
is: C00067
is: CHEBI:16842
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0074
initial amount: NaN
in compartment: 990318

metaid_0000085
type: SBMLUnitsDef
unit: 613831
notes: Default unit of substance redefined to micromole by comparison with the article. Nicolas Le Novere
name: micromole (new default)

613831
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

991614
type: Reaction
kinetic law: 616403
reactant: 616391
is: GO:0008517
fast: false
reversible: false

616415
type: LocalParameter
value: 0.063

616391
type: SpeciesReference
stoichiometry: 1.0
species: 990635

991398
type: Reaction
kinetic law: 615896
product: 615884
reactant: 615872
is version of: http://identifiers.org/ec-code/6.3.2.17
fast: false
reversible: false

615908
type: LocalParameter
value: 0.129

615884
type: SpeciesReference
stoichiometry: 1.0
species: 990615

615872
type: SpeciesReference
stoichiometry: 1.0
species: 990595

991302
type: Reaction
product: 615451
is: R00939
reactant: 615438
kinetic law: 615476
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
modifier: 615463
fast: false

615451
type: SpeciesReference
stoichiometry: 1.0
species: 990435

615438
type: SpeciesReference
stoichiometry: 1.0
species: 990355

615488
type: LocalParameter
value: 2109.4

990375
type: Species
is version of: C00415
name: dihydrofolate bound
is version of: CHEBI:15633
initial amount: NaN
in compartment: 990318
constant: false
has only substance units: false
initial concentration: 0.0024
boundary condition: true

990795
type: Species
is: C01937
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990332

990332
type: Compartment
is: GO:0005615
constant: true
size: 1.0
spatial dimensions: 3.0

990755
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

991878
type: Reaction
kinetic law: 617124
modifier: 617112
product: 617100
fast: false
reversible: false

617148
type: LocalParameter
value: 0.04416

617136
type: LocalParameter
value: 0.0192

617100
type: SpeciesReference
stoichiometry: 1.0
species: 990394

991738
type: Reaction
kinetic law: 616716
product: 616704
reactant: 616692
reactant: 616680
fast: false
reversible: false

616728
type: LocalParameter
value: 163000.0

616704
type: SpeciesReference
stoichiometry: 1.0
species: 990755

616692
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616680
type: SpeciesReference
stoichiometry: 1.0
species: 990655

991718
type: Reaction
kinetic law: 616656
product: 616644
reactant: 616632
reactant: 616620
fast: false
reversible: false

616668
type: LocalParameter
value: 85100.0

616644
type: SpeciesReference
stoichiometry: 1.0
species: 990735

990735
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

616632
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616620
type: SpeciesReference
stoichiometry: 1.0
species: 990635

990915
type: Species
is: C00064
is: CHEBI:18050
constant: false
boundary condition: true
has only substance units: false
initial concentration: 7170.0
initial amount: NaN
in compartment: 990318

991858
type: Reaction
kinetic law: 617076
product: 617064
product: 617052
reactant: 617040
fast: false
reversible: false

617088
type: LocalParameter
value: 0.42

617064
type: SpeciesReference
stoichiometry: 1.0
species: 990394

617052
type: SpeciesReference
stoichiometry: 1.0
species: 990674

617040
type: SpeciesReference
stoichiometry: 1.0
species: 990775

991675
type: Reaction
kinetic law: 616535
product: 616523
reactant: 616511
reactant: 616499
fast: false
reversible: false

616547
type: LocalParameter
value: 23100.0

616523
type: SpeciesReference
stoichiometry: 1.0
species: 990694

990694
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

616511
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616499
type: SpeciesReference
stoichiometry: 1.0
species: 990595

991655
type: Reaction
kinetic law: 616475
reactant: 616463
is version of: GO:0008517
fast: false
reversible: false

616487
type: LocalParameter
value: 0.063

616463
type: SpeciesReference
stoichiometry: 1.0
species: 990674

991635
type: Reaction
kinetic law: 616439
reactant: 616427
is version of: GO:0008517
fast: false
reversible: false

616451
type: LocalParameter
value: 0.063

616427
type: SpeciesReference
stoichiometry: 1.0
species: 990655

991896
type: Reaction
kinetic law: 617184
modifier: 617172
reactant: 617160
fast: false
reversible: false

617196
type: LocalParameter
value: 0.03

617160
type: SpeciesReference
stoichiometry: 1.0
species: 990394

990834
type: Species
is: C03838
constant: false
boundary condition: true
has only substance units: false
initial concentration: 689.6
initial amount: NaN
in compartment: 990318

991594
type: Reaction
kinetic law: 616367
reactant: 616355
is: GO:0008517
fast: false
reversible: false

616379
type: LocalParameter
value: 0.0

616355
type: SpeciesReference
stoichiometry: 1.0
species: 990615

991380
type: Reaction
kinetic law: 615824
modifier: 615812
product: 615800
reactant: 615788
is version of: http://identifiers.org/ec-code/6.3.5.3
fast: false
reversible: false

615860
type: LocalParameter
value: 100.0

615848
type: LocalParameter
value: 100.0

615836
type: LocalParameter
value: 4656.0

615800
type: SpeciesReference
stoichiometry: 1.0
species: 990574

615788
type: SpeciesReference
stoichiometry: 1.0
species: 990554

metaid_0000086
type: SBMLUnitsDef
unit: 613843
notes: Default unit of time redefined to hour by comparison with the article. Nicolas Le Novere
name: heure (new default)

613843
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

991456
type: Reaction
kinetic law: 616040
product: 616028
reactant: 616016
is version of: http://identifiers.org/ec-code/6.3.2.17
fast: false
reversible: false

616052
type: LocalParameter
value: 0.185

616028
type: SpeciesReference
stoichiometry: 1.0
species: 990674

616016
type: SpeciesReference
stoichiometry: 1.0
species: 990655

991698
type: Reaction
kinetic law: 616596
product: 616584
reactant: 616572
reactant: 616560
fast: false
reversible: false

616608
type: LocalParameter
value: 44300.0

616584
type: SpeciesReference
stoichiometry: 1.0
species: 990714

990714
type: Species
is: C01937
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 990318

616572
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616560
type: SpeciesReference
stoichiometry: 1.0
species: 990615

991838
type: Reaction
kinetic law: 617016
product: 617004
product: 616992
reactant: 616980
fast: false
reversible: false

617028
type: LocalParameter
value: 0.42

617004
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616992
type: SpeciesReference
stoichiometry: 1.0
species: 990655

616980
type: SpeciesReference
stoichiometry: 1.0
species: 990755

991818
type: Reaction
kinetic law: 616956
product: 616944
product: 616932
reactant: 616920
fast: false
reversible: false

616968
type: LocalParameter
value: 0.42

616944
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616932
type: SpeciesReference
stoichiometry: 1.0
species: 990635

616920
type: SpeciesReference
stoichiometry: 1.0
species: 990735

991798
type: Reaction
kinetic law: 616896
product: 616884
product: 616872
reactant: 616860
fast: false
reversible: false

616908
type: LocalParameter
value: 0.42

616884
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616872
type: SpeciesReference
stoichiometry: 1.0
species: 990615

616860
type: SpeciesReference
stoichiometry: 1.0
species: 990714

991130
type: Reaction
fast: false
is: R00946
is version of: http://identifiers.org/ec-code/2.1.1.13
reactant: 614375
product: 614399
reversible: false
reactant: 614387
kinetic law: 614411

614375
type: SpeciesReference
stoichiometry: 1.0
species: 990475

614399
type: SpeciesReference
stoichiometry: 1.0
species: 990435

614387
type: SpeciesReference
stoichiometry: 1.0
species: 990994

990994
type: Species
is: C05330
is: CHEBI:17230
constant: false
boundary condition: true
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 990318

614448
type: LocalParameter
value: 2900.0

614436
type: LocalParameter
value: 125.0

614423
type: LocalParameter
value: 22600.0

991346
type: Reaction
reactant: 615548
modifier: 615584
product: 615572
fast: false
modifier: 615632
is: R04560
modifier: 615608
modifier: 615596
modifier: 615620
kinetic law: 615656
modifier: 615644
reactant: 615560
reversible: false
is version of: http://identifiers.org/ec-code/2.1.2.3

615548
type: SpeciesReference
stoichiometry: 1.0
species: 990515

615572
type: SpeciesReference
stoichiometry: 1.0
species: 990355

615704
type: LocalParameter
value: 2.89

615716
type: LocalParameter
value: 5.5

615728
type: LocalParameter
value: 40.0

615740
type: LocalParameter
value: 31.5

615752
type: LocalParameter
value: 2.33

615680
type: LocalParameter
value: 5.3

615764
type: LocalParameter
value: 3.61

615668
type: LocalParameter
value: 9503.0

615692
type: LocalParameter
value: 24.0

615776
type: LocalParameter
value: 5.89

615560
type: SpeciesReference
stoichiometry: 1.0
species: 990574

991778
type: Reaction
kinetic law: 616836
product: 616824
product: 616812
reactant: 616800
fast: false
reversible: false

616848
type: LocalParameter
value: 0.42

616824
type: SpeciesReference
stoichiometry: 1.0
species: 990394

616812
type: SpeciesReference
stoichiometry: 1.0
species: 990595

616800
type: SpeciesReference
stoichiometry: 1.0
species: 990694

991078
type: Reaction
kinetic law: 614122
product: 614109
product: 614097
reactant: 614085
fast: false
reversible: false

614134
type: LocalParameter
value: 0.3

614109
type: SpeciesReference
stoichiometry: 1.0
species: 990534

614097
type: SpeciesReference
stoichiometry: 1.0
species: 990435

614085
type: SpeciesReference
stoichiometry: 1.0
species: 990455

991058
type: Reaction
kinetic law: 614061
product: 614049
reactant: 614037
reactant: 614025
fast: false
reversible: false

614073
type: LocalParameter
value: 23.2

614049
type: SpeciesReference
stoichiometry: 1.0
species: 990455

614037
type: SpeciesReference
stoichiometry: 1.0
species: 990534

614025
type: SpeciesReference
stoichiometry: 1.0
species: 990435

991017
type: Reaction
reversible: false
reactant: 613868
is: R00945
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: 613856
fast: false
kinetic law: 613892
product: 613880

613868
type: SpeciesReference
stoichiometry: 1.0
species: 990854

990854
type: Species
is: C00065
is: CHEBI:17115
constant: false
boundary condition: true
has only substance units: false
initial concentration: 123.3
initial amount: NaN
in compartment: 990318

613856
type: SpeciesReference
stoichiometry: 1.0
species: 990435

613928
type: LocalParameter
value: 210.0

613916
type: LocalParameter
value: 1.7

613904
type: LocalParameter
value: 18330.0

613880
type: SpeciesReference
stoichiometry: 1.0
species: 990455

991437
type: Reaction
kinetic law: 615992
product: 615980
reactant: 615968
is version of: http://identifiers.org/ec-code/6.3.2.17
fast: false
reversible: false

616004
type: LocalParameter
value: 0.118

615980
type: SpeciesReference
stoichiometry: 1.0
species: 990655

615968
type: SpeciesReference
stoichiometry: 1.0
species: 990635

991417
type: Reaction
kinetic law: 615944
product: 615932
reactant: 615920
is version of: http://identifiers.org/ec-code/6.3.2.17
fast: false
reversible: false

615956
type: LocalParameter
value: 0.369

615932
type: SpeciesReference
stoichiometry: 1.0
species: 990635

615920
type: SpeciesReference
stoichiometry: 1.0
species: 990615

991936
type: Reaction
kinetic law: 617280
product: 617268
reactant: 617256
fast: false
reversible: false

617292
type: LocalParameter
value: 0.03

617268
type: SpeciesReference
stoichiometry: 1.0
species: 990595

617256
type: SpeciesReference
stoichiometry: 1.0
species: 990694

991916
type: Reaction
kinetic law: 617232
modifier: 617220
product: 617208
fast: false
reversible: false

617244
type: LocalParameter
value: 0.03

617208
type: SpeciesReference
stoichiometry: 1.0
species: 990355

metaid_0000087
type: Parameter
constant: true
value: 0.32

991577
type: Reaction
kinetic law: 616330
reactant: 616318
is: GO:0008517
fast: false
reversible: false

616342
type: LocalParameter
value: 4.65

616318
type: SpeciesReference
stoichiometry: 1.0
species: 990595

991557
type: Reaction
kinetic law: 616282
product: 616270
reactant: 616258
is: GO:0008517
fast: false
reversible: false

616306
type: LocalParameter
value: 8.2

616294
type: LocalParameter
value: 82.2

616270
type: SpeciesReference
stoichiometry: 1.0
species: 990595

616258
type: SpeciesReference
stoichiometry: 1.0
species: 990795

991170
type: Reaction
reactant: 614581
modifier: 614685
is: R04325
kinetic law: 614711
modifier: 614659
fast: false
modifier: 614672
product: 614594
modifier: 614620
reactant: 614569
modifier: 614633
is: REACT 1509
is version of: http://identifiers.org/ec-code/2.1.2.2
modifier: 614698
modifier: 614646
reversible: false
product: 614607

614581
type: SpeciesReference
stoichiometry: 1.0
species: 990834

614737
type: LocalParameter
value: 4.9

614813
type: LocalParameter
value: 43.0

614763
type: LocalParameter
value: 5.0

614776
type: LocalParameter
value: 1.0

614825
type: LocalParameter
value: 31.0

614837
type: LocalParameter
value: 22.0

614788
type: LocalParameter
value: 84.0

614750
type: LocalParameter
value: 52.0

614724
type: LocalParameter
value: 4126.0

614801
type: LocalParameter
value: 60.0

614594
type: SpeciesReference
stoichiometry: 1.0
species: 990554

614569
type: SpeciesReference
stoichiometry: 1.0
species: 990495

614607
type: SpeciesReference
stoichiometry: 1.0
species: 990435

990414
type: Species
is: P00374
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.64
initial amount: NaN
in compartment: 990318
name: dihydrofolate reductase total

991496
type: Reaction
kinetic law: 616136
product: 616124
reactant: 616112
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
reversible: false

616148
type: LocalParameter
value: 0.025

616124
type: SpeciesReference
stoichiometry: 1.0
species: 990615

616112
type: SpeciesReference
stoichiometry: 1.0
species: 990635

991038
type: Reaction
product: 613952
is: R00945
reversible: false
fast: false
kinetic law: 613976
reactant: 613940
modifier: 613964
is version of: http://identifiers.org/ec-code/2.1.2.1

613952
type: SpeciesReference
stoichiometry: 1.0
species: 990435

614013
type: LocalParameter
value: 10000.0

614000
type: LocalParameter
value: 3200.0

613988
type: LocalParameter
value: 1.22E7

613940
type: SpeciesReference
stoichiometry: 1.0
species: 990455

990935
type: Species
is: C00037
is: CHEBI:15428
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1600.0
initial amount: NaN
in compartment: 990318

991476
type: Reaction
kinetic law: 616088
product: 616076
reactant: 616064
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
reversible: false

616100
type: LocalParameter
value: 0.195

616076
type: SpeciesReference
stoichiometry: 1.0
species: 990595

616064
type: SpeciesReference
stoichiometry: 1.0
species: 990615

991996
type: Reaction
kinetic law: 617424
product: 617412
reactant: 617400
fast: false
reversible: false

617436
type: LocalParameter
value: 0.03

617412
type: SpeciesReference
stoichiometry: 1.0
species: 990655

617400
type: SpeciesReference
stoichiometry: 1.0
species: 990755

991976
type: Reaction
kinetic law: 617376
product: 617364
reactant: 617352
fast: false
reversible: false

617388
type: LocalParameter
value: 0.03

617364
type: SpeciesReference
stoichiometry: 1.0
species: 990635

617352
type: SpeciesReference
stoichiometry: 1.0
species: 990735

991956
type: Reaction
kinetic law: 617328
product: 617316
reactant: 617304
fast: false
reversible: false

617340
type: LocalParameter
value: 0.03

617316
type: SpeciesReference
stoichiometry: 1.0
species: 990615

617304
type: SpeciesReference
stoichiometry: 1.0
species: 990714

991328
type: Reaction
kinetic law: 615524
product: 615512
reactant: 615500
is version of: http://identifiers.org/ec-code/6.3.4.17
is: R02238
fast: false
reversible: false

615536
type: LocalParameter
value: 65.0

615512
type: SpeciesReference
stoichiometry: 1.0
species: 990515

615500
type: SpeciesReference
stoichiometry: 1.0
species: 990355

991536
type: Reaction
kinetic law: 616234
product: 616221
reactant: 616209
is: http://identifiers.org/ec-code/3.4.19.9
fast: false
reversible: false

616246
type: LocalParameter
value: 0.191

616221
type: SpeciesReference
stoichiometry: 1.0
species: 990655

616209
type: SpeciesReference
stoichiometry: 1.0
species: 990674

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

W3 CDTF: Wed Jun 29 11:22:41 BST 2005

ORG:
  orgname: CASE western research university
n:
  given: Tomas
  family: Radivoyevitch

W3 CDTF: Thu Jul 05 15:40:37 BST 2012