BIOMD0000000005
type: SBMLModel
species: metaid_0000020
reaction: 000017
rule: metaid_0000023
modified:
  W3 CDTF: Thu May 16 15:40:43 BST 2013
volume units: volume
compartment: 000002
time units: time
created:
  W3 CDTF: Tue Feb 08 18:28:27 GMT 2005
reaction: 000013
reaction: 000010
reaction: 000014
species: 000004
is described by: http://identifiers.org/pubmed/1831270
species: 000005
is: MODEL6614644188
curated: true
is version of: sce04111
reaction: 000018
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
rule: metaid_0000021
species: 000008
species: 000009
occurs in: http://identifiers.org/taxonomy/33154
name: Tyson1991 - Cell Cycle 6 var
species: metaid_0000022
length unit: length
reaction: 000011
reaction: 000015
reaction: 000016
species: 000003
has version: REACT 152
notes: Tyson1991 - Cell Cycle 6 var Mathematical model of the interactions of cdc2 and cyclin. This model is described in the article: Modeling the cell division cycle: cdc2 and cyclin interactions. Tyson JJ. Proc. Natl. Acad. Sci. U.S.A. 1991; 88(16); 7328-32 Abstract: The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells. This model is hosted on BioModels Database and identified by: BIOMD0000000005 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
area units: area
creator:
  ORG:
    orgname: NASA Jet Propulsion Laboratory
  n:
    given: Bruce
    family: Shapiro
reaction: 000012
is version of: GO:0000278
species: 000006
species: 000007
substance units: substance

metaid_0000020
type: Species
is version of: IPR006670
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 000002
name: total_cyclin

000002
type: Compartment
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0

000017
type: Reaction
kinetic law: 712670
product: 712658
reactant: 712646
is version of: GO:0008054
fast: false
reversible: false
name: cdc2 kinase triggered degration of cyclin

840225
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value: 0.6

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type: Species
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constant: false
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has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 000002
name: p-cyclin

000013
type: Reaction
kinetic law: 712526
reversible: false
has version: REACT 6216
fast: false
reactant: 712490
product: 712514
has version: REACT 6308
name: cyclin cdc2k-p association
reactant: 712502

840217
type: LocalParameter
value: 200.0

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species: 000005

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initial concentration: NaN
initial amount: 0.75
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name: cdc2k-P

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initial concentration: NaN
name: p-cyclin_cdc2-p
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initial amount: 0.25

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name: cyclin

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type: Reaction
has version: REACT 6308
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product: 712394
reversible: false
name: cyclin_cdc2k dissociation
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product: 712382
fast: false

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name: p-cyclin_cdc2
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name: cdc2k

000014
type: Reaction
has version: REACT 3178
fast: false
is version of: GO:0045736
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is version of: http://identifiers.org/ec-code/2.7.10.2
reversible: false
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kinetic law: 712562
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name: deactivation of cdc2 kinase
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has version: REACT 6294
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name: activation of cdc2 kinase
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712694
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metaid_0000022
type: Species
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name: total_cdc2

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value: 0.018

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value: 180.0

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kinetic law: 712442
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is version of: GO:0006468
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: cdc2k phosphorylation

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kinetic law: 712598
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reactant: 712574
is version of: GO:0006412
fast: false
reversible: false
name: cyclin biosynthesis

840221
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value: 0.015

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kinetic law: 712634
product: 712622
reactant: 712610
is version of: GO:0008054
fast: false
reversible: false
name: default degradation of cyclin

840223
type: LocalParameter
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712622
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000012
type: Reaction
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product: 712466
reactant: 712454
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: cdc2k dephosphorylation

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type: LocalParameter
value: 1000.0

712466
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stoichiometry: 1.0
species: 000004

712454
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species: 000005