UnificationXref79
type: UnificationXref
id: REACT_151686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151686.1

UnificationXref77
type: UnificationXref
id: P50532
db: UniProt

UnificationXref78
type: UnificationXref
id: 2520839
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520839

UnificationXref76
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref75
type: UnificationXref
id: 113592
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref74
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref73
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref72
type: UnificationXref
id: REACT_150280
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150280.2

UnificationXref71
type: UnificationXref
id: 2445086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445086

http://identifiers.org/pubmed/12857742
type: PublicationXref
id: 12857742
author: StrÃ¼bing, C
author: Krapivinsky, G
author: Clapham, DE
author: Krapivinsky, L
db: Pubmed
title: Formation of novel TRPC channels by complex subunit interactions in embryonic brain
source: J Biol Chem 278:39014-9
year: 2003

UnificationXref70
type: UnificationXref
id: REACT_150684
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150684.1

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 270

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 282

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 21

UnificationXref66
type: UnificationXref
id: REACT_152433
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152433.1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 447

UnificationXref67
type: UnificationXref
id: 2445081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445081

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref68
type: UnificationXref
id: REACT_152023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152023.1

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 406

UnificationXref69
type: UnificationXref
id: 2445084
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445084

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref63
type: UnificationXref
id: 2445075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445075

phosphatidyl-L-serine
type: SmallMoleculeReference
name: phosphatidyl-L-serines
name: phosphatidyl-L-serine [ChEBI:18303]
xref: UnificationXref163

UnificationXref62
type: UnificationXref
id: Q6GQG3
db: UniProt

UnificationXref65
type: UnificationXref
id: 2445082
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445082

UnificationXref64
type: UnificationXref
id: REACT_150973
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150973.1

UnificationXref61
type: UnificationXref
id: REACT_151023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151023.1

UnificationXref60
type: UnificationXref
id: 2445076
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445076

Stoichiometry8
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 5.0

Xenopus Mcm8 mediated fork unwinding
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref33
xref: http://identifiers.org/pubmed/15707891
xref: UnificationXref32
left: Replication Fork
comment: Authored: Tye, BK, 2005-11-29 15:49:00
comment: Mcm8 is related to the Mcm2-7 helicase and is found in vertebrates but not in C. elegans or the yeasts. Studies in Xenopus egg extracts showed that Mcm8 does not associate with the soluble Mcm2-7 complex and binds chromatin upon initiation of DNA synthesis. Mcm8 depletion does not affect replication licensing or Mcm3 loading but slows down DNA synthesis and reduces chromatin recruitment of Rpa34 and DNA polymerase-alpha. Recombinant Mcm8 has ATPase and helicase activities.
right: Unwound fork

Stoichiometry7
type: Stoichiometry
physical entity: p-S67-Ensa/p-S67-Arpp19
stoichiometric coefficient: 1.0

p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/21164014
xref: UnificationXref72
xref: http://identifiers.org/pubmed/21164013
xref: UnificationXref71
left: p-S67-Ensa/p-S67-Arpp19
left: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
comment: Authored: Orlic-Milacic, M, 2012-09-04
comment: Reviewed: Burgess, A, 2012-09-28
comment: Recombinant Xenopus Ensa and Arpp19 are phosphorylated by recombinant Xenopus Mastl on serine residue S67. Once phosphorylated, Ensa and Arpp19 bind and inhibit the phosphatase activity of PP2A complexed with the regulatory subunit Ppp2r2d (B55-delta) (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).
comment: Edited: Gillespie, ME, 2012-09-14
comment: Reviewed: Mochida, Satoru, 2012-09-26
right: p-S67-Ensa/p-S67-Arpp19:PP2A-Ppp2r2d

Cdk1 phosphorylates condensin I
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.22
xref: UnificationXref125
xref: UnificationXref124
xref: http://identifiers.org/pubmed/9774278
participant stoichiometry: Stoichiometry14
participant stoichiometry: Stoichiometry8
left: Smc2:Smc4:Ncapd2:Ncapg:Ncaph
left: Adenosine 5'-triphosphate
comment: Edited: Matthews, L, 2012-10-18
comment: Reviewed: Anonymous, 2012-11-12
comment: Cdk1 (Cdc2) in complex with Ccnb (cyclin B) phosphorylates condensin I subunits Ncapd2, Ncapg and Ncaph in mitotic Xenopus egg extracts. While phosphorylation sites in Ncapg and Ncaph have not been identified, Ncapd2 is phosphorylated on threonine residues T1314, T1348 and T1353 (Kimura et al. 1998) which are conserved in human and mouse orthologs. Phosphorylation by Cdk1 enables condensin I to introduce positive supercoils into DNA and promotes chromatin condensation (Kimura et al. 1998).
comment: Edited: D'Eustachio, P, 2012-10-19
comment: Authored: Orlic-Milacic, M, 2012-10-12
right: Smc2:Smc4:p-T1314,1348,1353-Ncapd2:Ncaph:Ncapg
right: Adenosine 5'-diphosphate

Stoichiometry6
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: PP2A-subunit A
stoichiometric coefficient: 1.0

Wnt11 binds Fzd7 to regulate convergent extension in Xenopus
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref135
xref: UnificationXref134
xref: http://identifiers.org/pubmed/10862746
left: Wnt11
left: Fzd7a
comment: Authored: Rothfels, K, 2013-09-13
comment: Reviewed: Kikuchi, Akira, 2013-11-12
comment: Edited: Matthews, L, 2013-10-07
comment: Direct binding between XWnt11 and XFzd7 has been demonstrated by co-immunoprecipitation in Xenopus embryos. In this system, Wnt11 and Fzd7 contribute to convergent extension during gastrulation (Djiane et al, 2000).
right: Wnt11:Fzd7a

Multiple Xenopus proteins are localized at replication fork
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/16483939
xref: UnificationXref152
xref: UnificationXref153
left: xGINS complex
left: xMcm8
left: xCdc45
left: Replication Fork
comment: At the beginning of this reaction, 1 molecule of 'Replication Fork', 1 molecule of 'xCdc45', 1 molecule of 'xMcm8', and 1 molecule of 'xGINS complex' are present. At the end of this reaction, 1 molecule of 'Xenopus unwinding complex at replication fork' is present. This reaction takes place in the 'nucleus'.
comment: Authored: Tye, BK, 2006-03-17 14:46:24
comment: Edited: Gopinathrao, G, 2006-03-17 14:47:28
right: Xenopus unwinding complex at replication fork

translocation of Xenopus prkca to plasma membrane
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/10395542
xref: UnificationXref170
xref: UnificationXref171
participant stoichiometry: Stoichiometry32
left: 1,2-Diacylglycerol
left: 3-O-sn-Phosphatidyl-L-serine
left: prkca
left: Calcium
comment: Authored: Rothfels, K, 2013-08-16
comment: Reviewed: Kikuchi, Akira, 2013-11-12
comment: Edited: Matthews, L, 2013-10-07
comment: Myc-tagged PKC alpha translocates from the cytosol to the plasma membrane when Xenopus embryos are co-injected with XWNT-5A, Rfz2, Mfz3, Mfz4, or Mfz6 RNA. In contrast, PKC activation was not observed upon co-injection with XWNT-8 or Rfz1 RNA, both of which have been shown to activate beta-catenin-dependent signaling (Sheldahl et al, 1999).
right: activated prkca

Xenopus kinesin-12 is a dimer
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/9813089
xref: UnificationXref178
xref: UnificationXref177
participant stoichiometry: Stoichiometry37
left: kif15-a
comment: Reviewed: Ouwehand, WH, 2010-11-12
comment: Authored: Akkerman, JW, 2010-10-29
comment: The kinesin-12 family member Xklp2 is a plus-end-directed dimeric kinesin.
comment: Edited: Jupe, S, 2010-11-15
right: Xklp2 dimer

Stoichiometry9
type: Stoichiometry
physical entity: Structural maintenance of chromosomes protein 4
stoichiometric coefficient: 1.0

UnificationXref99
type: UnificationXref
id: REACT_152081
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152081.1

Stoichiometry4
type: Stoichiometry
physical entity: PP2A-catalytic subunit C
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
stoichiometric coefficient: 1.0

Stoichiometry2
type: Stoichiometry
physical entity: NODAL_XENLA
stoichiometric coefficient: 1.0

Stoichiometry1
type: Stoichiometry
physical entity: CER1_XENLA
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
name: Calcium [ChEBI:29108]
name: Ca2+
xref: UnificationXref154

UnificationXref94
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref93
type: UnificationXref
id: REACT_152381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152381.1

UnificationXref92
type: UnificationXref
id: 2520852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520852

UnificationXref91
type: UnificationXref
id: REACT_151734
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151734.1

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref98
type: UnificationXref
id: 2520850
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520850

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 309

UnificationXref97
type: UnificationXref
id: MOD:00047
db: MOD

UnificationXref96
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref95
type: UnificationXref
id: 29370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref90
type: UnificationXref
id: 2520846
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520846

UnificationXref88
type: UnificationXref
id: REACT_150766
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150766.1

UnificationXref89
type: UnificationXref
id: O13067
db: UniProt

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref17

UnificationXref81
type: UnificationXref
id: 2520848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520848

UnificationXref80
type: UnificationXref
id: Q9YHB5
db: UniProt

UnificationXref83
type: UnificationXref
id: Q9YHY6
db: UniProt

UnificationXref82
type: UnificationXref
id: REACT_152205
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152205.1

UnificationXref85
type: UnificationXref
id: REACT_150803
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150803.1

UnificationXref84
type: UnificationXref
id: 2520855
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520855

UnificationXref87
type: UnificationXref
id: 2520844
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520844

UnificationXref86
type: UnificationXref
id: P50533
db: UniProt

ccnb2
type: ProteinReference
name: UniProt:P13351 ccnb2
xref: UnificationXref117
comment: SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily.
organism: Xenopus laevis

UnificationXref178
type: UnificationXref
id: REACT_25157
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25157.1

UniProt:P13350 ccnb1
type: ProteinReference
name: ccnb1
xref: UnificationXref114
comment: SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily.
organism: Xenopus laevis

UnificationXref176
type: UnificationXref
id: REACT_26722
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26722.1

activated prkca
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry36
component stoichiometry: Stoichiometry33
component stoichiometry: Stoichiometry35
component stoichiometry: Stoichiometry34
component: 1,2-Diacylglycerol
component: 3-O-sn-Phosphatidyl-L-serine
component: prkca
component: Calcium
xref: UnificationXref168
xref: UnificationXref169
cellular location: plasma membrane
comment: Reactome DB_ID: 4332386

UnificationXref177
type: UnificationXref
id: 984820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984820

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref94

UnificationXref170
type: UnificationXref
id: 4332392
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4332392

D-1,2-Diacylglycerol
type: SmallMoleculeReference
name: 1,2-diacyl-sn-glycerol
name: 1,2-Diacylglycerol
name: 1,2-diacyl-sn-glycerols
name: 1,2-diacyl-sn-glycerol [ChEBI:17815]
xref: UnificationXref160

UnificationXref171
type: UnificationXref
id: REACT_172593
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_172593.2

UnificationXref172
type: UnificationXref
id: Q91785
db: UniProt

UnificationXref173
type: UnificationXref
id: 984841
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984841

UnificationXref174
type: UnificationXref
id: REACT_26966
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26966.1

UnificationXref175
type: UnificationXref
id: 984831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984831

Xklp2 dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry38
component: kif15-a
xref: UnificationXref176
xref: UnificationXref175
cellular location: cytosol
comment: Reactome DB_ID: 984831

UnificationXref166
type: UnificationXref
id: 4332325
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4332325

UnificationXref165
type: UnificationXref
id: REACT_20468
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20468.2

UnificationXref168
type: UnificationXref
id: 4332386
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4332386

UnificationXref167
type: UnificationXref
id: REACT_173553
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173553.1

UnificationXref169
type: UnificationXref
id: REACT_173564
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173564.1

UnificationXref160
type: UnificationXref
id: CHEBI:17815
db: ChEBI

UnificationXref163
type: UnificationXref
id: CHEBI:18303
db: ChEBI

UnificationXref164
type: UnificationXref
id: 33625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=33625

UnificationXref161
type: UnificationXref
id: 114519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114519

UnificationXref162
type: UnificationXref
id: REACT_3927
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3927.5

UnificationXref157
type: UnificationXref
id: Q6AZF7
db: UniProt

Cerberus binds Nodal
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/10067895
xref: UnificationXref11
xref: UnificationXref12
left: NODAL_XENLA
left: CER1_XENLA
comment: Cerberus binds Xnr-1, the Xenopus Nodal homolog, and negatively regulates Xnr-1 signaling (Piccolo et al. 1999).
comment: Reviewed: Peng, C, 2011-08-24
comment: Edited: May, B, 2011-01-27
comment: Authored: May, B, 2011-01-27
right: Cerberus:Nodal

UnificationXref156
type: UnificationXref
id: REACT_5631
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5631.2

Activation of TRPC channels by Netrin-1
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/12857742
xref: http://identifiers.org/pubmed/18471901
xref: UnificationXref23
xref: UnificationXref22
left: TRPC1_Xenopus
left: diacylglycerols
comment: Reviewed: Cooper, HM, 2010-02-16
comment: Edited: Garapati, P V, 2010-04-23
comment: Netrin-1, through its activation of DCC, triggers TRPC channel mediating the Ca+2 influx that is required for the growth cone turning. The effect of netrin-1 on TRP currents in the neurons is studied in Xenopus. In cultured Xenopus spinal neurons, Netrin-1 evoked Ca+2 influx and a depolarizing, TRPC-like current in both soma and growth cones. Inhibition of the Xenopus homologue of mammalian TRPC1 (XTRPC1) prevented Ca+2 influx, TRPC-like current activation and the chemotropic turning of the growth cone in response to a gradient of Netrin-1. Netrin-1 receptor signalling to TRPC channels is mediated via hydrolysis of PIP2 by PLCgamma which then activates TRPC channel activity through IP3 and DAG.
comment: Authored: Garapati, P V, 2010-04-23
right: Activated xtrpc1
right: diacylglycerols

UnificationXref155
type: UnificationXref
id: 74016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74016

UnificationXref154
type: UnificationXref
id: CHEBI:29108
db: ChEBI

UnificationXref159
type: UnificationXref
id: REACT_173552
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173552.1

UnificationXref158
type: UnificationXref
id: 4332328
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4332328

cytosol
type: CellularLocationVocabulary
xref: UnificationXref73

UnificationXref150
type: UnificationXref
id: 176972
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176972

UnificationXref151
type: UnificationXref
id: REACT_7728
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7728.1

UnificationXref152
type: UnificationXref
id: 176971
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176971

UnificationXref153
type: UnificationXref
id: REACT_6943
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6943.3

http://identifiers.org/pubmed/9813089
type: PublicationXref
id: 9813089
author: Boleti, H
author: Wittmann, T
author: Vernos, I
author: Antony, C
author: Karsenti, E
db: Pubmed
title: Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
source: J Cell Biol 143:673-85
year: 1998

UnificationXref148
type: UnificationXref
id: 176954
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176954

UnificationXref147
type: UnificationXref
id: Q9YHZ6
db: UniProt

UnificationXref149
type: UnificationXref
id: REACT_7229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7229.1

UnificationXref144
type: UnificationXref
id: REACT_7713
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7713.1

UnificationXref143
type: UnificationXref
id: 176950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176950

UnificationXref146
type: UnificationXref
id: REACT_7299
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7299.1

UnificationXref145
type: UnificationXref
id: 176953
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176953

UnificationXref9
type: UnificationXref
id: 1181343
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181343

UnificationXref8
type: UnificationXref
id: REACT_111831
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111831.1

UnificationXref141
type: UnificationXref
id: 176951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176951

UnificationXref3
type: UnificationXref
id: P70041
db: UniProt

UnificationXref142
type: UnificationXref
id: REACT_7377
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7377.1

UnificationXref2
type: UnificationXref
id: 8355
db: NCBI Taxonomy

UnificationXref1
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

UnificationXref140
type: UnificationXref
id: REACT_7280
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7280.1

UnificationXref7
type: UnificationXref
id: 1181119
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181119

UniProt:P70041 cer1
type: ProteinReference
name: cer
name: cer1
xref: UnificationXref3
comment: SIMILARITY Belongs to the DAN family.SIMILARITY Contains 1 CTCK (C-terminal cystine knot-like) domain.
organism: Xenopus laevis

UnificationXref6
type: UnificationXref
id: Q91619
db: UniProt

UnificationXref5
type: UnificationXref
id: REACT_111558
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111558.1

UnificationXref4
type: UnificationXref
id: 1181319
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181319

UnificationXref139
type: UnificationXref
id: 176946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176946

UnificationXref138
type: UnificationXref
id: Q7ZT46
db: UniProt

UnificationXref137
type: UnificationXref
id: REACT_7031
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7031.1

UnificationXref136
type: UnificationXref
id: 176957
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176957

UnificationXref135
type: UnificationXref
id: REACT_172674
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_172674.2

UnificationXref134
type: UnificationXref
id: 4568832
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4568832

UnificationXref133
type: UnificationXref
id: REACT_173398
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173398.1

UnificationXref132
type: UnificationXref
id: 4568830
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4568830

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18471901
type: PublicationXref
id: 18471901
author: Voets, T
author: Nilius, B
author: Talavera, K
db: Pubmed
title: Neuronal TRP channels: thermometers, pathfinders and life-savers
source: Trends Neurosci 31:287-95
year: 2008

ppp2ca
type: ProteinReference
name: UniProt:Q8AVH9
xref: UnificationXref37
comment: CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
organism: Xenopus laevis

UniProt:P50533 smc2
type: ProteinReference
name: cape
name: smc2l1
name: smc2
xref: UnificationXref86
comment: SIMILARITY Belongs to the SMC family. SMC2 subfamily.
organism: Xenopus laevis

capc
type: ProteinReference
name: smc4l1
name: smc4
name: UniProt:P50532 smc4
xref: UnificationXref77
comment: SIMILARITY Belongs to the SMC family. SMC4 subfamily.
organism: Xenopus laevis

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 117

ppp2r2d
type: ProteinReference
name: UniProt:Q7ZX64 ppp2r2d
xref: UnificationXref34
comment: MISCELLANEOUS ppp2r2d is an abundant subunit in egg extracts and represents 70% or more of B55 subunits (PubMed:19793917).SIMILARITY Belongs to the phosphatase 2A regulatory subunit B family.SIMILARITY Contains 7 WD repeats.
organism: Xenopus laevis

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 67

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 117

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 1034

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1364

Stoichiometry14
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 5.0

Stoichiometry15
type: Stoichiometry
physical entity: p-xCAP-H
stoichiometric coefficient: 1.0

Stoichiometry16
type: Stoichiometry
physical entity: Structural maintenance of chromosomes protein 4
stoichiometric coefficient: 1.0

Stoichiometry17
type: Stoichiometry
physical entity: p-T1314,1348,1353-XCAP-D2
stoichiometric coefficient: 1.0

Stoichiometry18
type: Stoichiometry
physical entity: p-xCAP-G
stoichiometric coefficient: 1.0

Stoichiometry19
type: Stoichiometry
physical entity: XCAP-E
stoichiometric coefficient: 1.0

cdc2x1.1
type: ProteinReference
name: cdk1-a
name: UniProt:P35567 cdk1-a
name: cdc2-a
xref: UnificationXref106
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.CATALYTIC ACTIVITY ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.PTM Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SIMILARITY Contains 1 protein kinase domain.
organism: Xenopus laevis

Same Catalyst Activity
type: RelationshipTypeVocabulary

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 309

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 589

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 1589

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 125

Stoichiometry11
type: Stoichiometry
physical entity: XCAP-D2
stoichiometric coefficient: 1.0

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 67

Stoichiometry10
type: Stoichiometry
physical entity: Condensin complex subunit 3
stoichiometric coefficient: 1.0

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 67

Stoichiometry13
type: Stoichiometry
physical entity: Condensin complex subunit 2
stoichiometric coefficient: 1.0

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry12
type: Stoichiometry
physical entity: XCAP-E
stoichiometric coefficient: 1.0

Stoichiometry29
type: Stoichiometry
physical entity: Replication Fork
stoichiometric coefficient: 1.0

Stoichiometry27
type: Stoichiometry
physical entity: xPSF2p
stoichiometric coefficient: 1.0

Stoichiometry28
type: Stoichiometry
physical entity: xMcm8
stoichiometric coefficient: 1.0

UnificationXref10
type: UnificationXref
id: REACT_111670
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111670.1

Stoichiometry25
type: Stoichiometry
physical entity: xPSF1p
stoichiometric coefficient: 1.0

Stoichiometry26
type: Stoichiometry
physical entity: xSLD5P
stoichiometric coefficient: 1.0

ppp2r1b
type: ProteinReference
name: UniProt:Q7ZYM9
xref: UnificationXref48
organism: Xenopus laevis

caph
type: ProteinReference
name: UniProt:O13067 ncaph
name: brrn1
name: ncaph
xref: UnificationXref89
comment: SIMILARITY Belongs to the CND2 (condensin subunit 2) family.
organism: Xenopus laevis

UnificationXref19
type: UnificationXref
id: REACT_12312
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12312.3

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 1364

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 1034

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 161

UnificationXref11
type: UnificationXref
id: 1181356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181356

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 302

Stoichiometry24
type: Stoichiometry
physical entity: xPSF3p
stoichiometric coefficient: 1.0

UnificationXref12
type: UnificationXref
id: REACT_111035
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111035.2

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry23
type: Stoichiometry
physical entity: Fzd7a
stoichiometric coefficient: 1.0

UnificationXref13
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Stoichiometry22
type: Stoichiometry
physical entity: Wnt11
stoichiometric coefficient: 1.0

fz7-a
type: ProteinReference
name: fzd7-a
name: UniProt:Q9PUK8 fzd7-a
xref: UnificationXref129
comment: SIMILARITY Belongs to the G-protein coupled receptor Fz/Smo family.SIMILARITY Contains 1 FZ (frizzled) domain.
organism: Xenopus laevis

UnificationXref14
type: UnificationXref
id: Q9PRI8
db: UniProt

Stoichiometry21
type: Stoichiometry
physical entity: Ccnb
stoichiometric coefficient: 1.0

UnificationXref15
type: UnificationXref
id: 622401
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622401

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry20
type: Stoichiometry
physical entity: p-T161-Cdk1
stoichiometric coefficient: 1.0

UnificationXref16
type: UnificationXref
id: REACT_22801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22801.1

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 302

UnificationXref17
type: UnificationXref
id: CHEBI:18035
db: ChEBI

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 161

UnificationXref18
type: UnificationXref
id: 112275
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=112275

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 1

Catalysis1
type: Catalysis
data source: Reactome
controlled: Xenopus Mcm8 mediated fork unwinding
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: xMcm8

Catalysis2
type: Catalysis
data source: Reactome
controlled: Cdk1 phosphorylates condensin I
control type: ACTIVATION
xref: RelationshipXref3
xref: RelationshipXref4
controller: p-T161-Cdk1:Ccnb

Stoichiometry36
type: Stoichiometry
physical entity: 3-O-sn-Phosphatidyl-L-serine
stoichiometric coefficient: 1.0

Stoichiometry37
type: Stoichiometry
physical entity: kif15-a
stoichiometric coefficient: 2.0

Stoichiometry38
type: Stoichiometry
physical entity: kif15-a
stoichiometric coefficient: 2.0

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 1203

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry33
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 3.0

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry32
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 3.0

Stoichiometry35
type: Stoichiometry
physical entity: 1,2-Diacylglycerol
stoichiometric coefficient: 1.0

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 1348

Stoichiometry34
type: Stoichiometry
physical entity: prkca
stoichiometric coefficient: 1.0

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 1353

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 699

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 1314

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref24

Stoichiometry31
type: Stoichiometry
physical entity: xCdc45
stoichiometric coefficient: 1.0

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 699

Stoichiometry30
type: Stoichiometry
physical entity: xGINS complex
stoichiometric coefficient: 1.0

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref30
type: UnificationXref
id: REACT_7799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7799.1

UnificationXref31
type: UnificationXref
id: MI:0355
db: MI

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref13

UnificationXref32
type: UnificationXref
id: 169440
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169440

UnificationXref38
type: UnificationXref
id: 2445067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445067

UnificationXref37
type: UnificationXref
id: Q8AVH9
db: UniProt

UnificationXref39
type: UnificationXref
id: REACT_151443
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151443.1

UnificationXref34
type: UnificationXref
id: Q7ZX64
db: UniProt

UnificationXref33
type: UnificationXref
id: REACT_6758
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6758.1

UnificationXref36
type: UnificationXref
id: REACT_151093
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151093.1

UnificationXref35
type: UnificationXref
id: 2445064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445064

http://identifiers.org/pubmed/21164014
type: PublicationXref
id: 21164014
author: Strub, JM
author: Brioudes, E
author: Van-Dorsselaer, A
author: Vigneron, S
author: Castro, A
author: Labbe, JC
author: Lorca, T
author: Gharbi-Ayachi, A
author: Burgess, Andrew
db: Pubmed
title: The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A
source: Science 330:1673-7
year: 2010

http://identifiers.org/pubmed/21164013
type: PublicationXref
id: 21164013
author: Skehel, Mark
author: Maslen, Sarah L
author: Mochida, Satoru
author: Hunt, Tim
db: Pubmed
title: Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
source: Science 330:1670-3
year: 2010

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 677

UnificationXref20
type: UnificationXref
id: 622399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622399

UnificationXref21
type: UnificationXref
id: REACT_23176
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23176.1

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 677

UnificationXref29
type: UnificationXref
id: 169493
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169493

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref28
type: UnificationXref
id: REACT_7610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7610.1

UnificationXref27
type: UnificationXref
id: 169509
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169509

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 549

UnificationXref26
type: UnificationXref
id: REACT_7812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7812.1

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 23

Xenopus laevis
type: BioSource
xref: UnificationXref2

UnificationXref25
type: UnificationXref
id: 169515
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169515

UnificationXref24
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref23
type: UnificationXref
id: REACT_22431
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22431.1

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22
type: UnificationXref
id: 622403
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622403

nodal
type: ProteinReference
name: UniProt:Q91619 nodal
name: nr1
xref: UnificationXref6
comment: SIMILARITY Belongs to the TGF-beta family.
organism: Xenopus laevis

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 397

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 352

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 392

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 1

klp2
type: ProteinReference
name: kif15-a
name: UniProt:Q91785 kif15-a
xref: UnificationXref172
comment: SIMILARITY Belongs to the kinesin-like protein family. KLP2 subfamily.SIMILARITY Contains 1 kinesin-motor domain.
organism: Xenopus laevis

gins2
type: ProteinReference
name: psf2
name: UniProt:Q7ZT46 gins2
xref: UnificationXref138
comment: SIMILARITY Belongs to the GINS2/PSF2 family.
organism: Xenopus laevis

UnificationXref50
type: UnificationXref
id: REACT_151479
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151479.1

UnificationXref51
type: UnificationXref
id: 2445065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445065

UnificationXref52
type: UnificationXref
id: REACT_151363
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151363.1

UnificationXref53
type: UnificationXref
id: 2445055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445055

UnificationXref54
type: UnificationXref
id: REACT_151438
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151438.1

UnificationXref56
type: UnificationXref
id: MOD:00046
db: MOD

UnificationXref55
type: UnificationXref
id: Q7ZXH9
db: UniProt

UnificationXref58
type: UnificationXref
id: REACT_152508
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152508.1

UnificationXref57
type: UnificationXref
id: 2445079
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445079

UnificationXref59
type: UnificationXref
id: Q6DEB4
db: UniProt

http://identifiers.org/pubmed/9774278
type: PublicationXref
id: 9774278
author: Kobayashi, R
author: Hirano, T
author: Hirano, M
author: Kimura, K
db: Pubmed
title: Phosphorylation and activation of 13S condensin by Cdc2 in vitro
source: Science 282:487-90
year: 1998

ppp2r1a
type: ProteinReference
name: UniProt:Q7ZWS7
xref: UnificationXref45
organism: Xenopus laevis

p-S67-Ensa/p-S67-Arpp19
type: PhysicalEntity
data source: Reactome
xref: UnificationXref67
xref: UnificationXref68
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445081
comment: Converted from EntitySet in Reactome
member physical entity: p-S67-Alpha-endosulfine
member physical entity: p-S67-Arpp19

xPSF3p
type: PhysicalEntity
data source: Reactome
xref: UnificationXref137
xref: UnificationXref136
cellular location: nucleoplasm
comment: Reactome DB_ID: 176957

Unwound fork
type: PhysicalEntity
data source: Reactome
xref: UnificationXref28
xref: UnificationXref27
cellular location: nucleoplasm
comment: Reactome DB_ID: 169509

xMcm8
type: PhysicalEntity
data source: Reactome
xref: UnificationXref29
xref: UnificationXref30
cellular location: nucleoplasm
comment: Reactome DB_ID: 169493

xSLD5P
type: PhysicalEntity
data source: Reactome
xref: UnificationXref141
xref: UnificationXref142
cellular location: nucleoplasm
comment: Reactome DB_ID: 176951

xPSF2p
type: PhysicalEntity
data source: Reactome
xref: UnificationXref144
xref: UnificationXref143
cellular location: nucleoplasm
comment: Reactome DB_ID: 176950

UnificationXref42
type: UnificationXref
id: REACT_151542
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151542.1

UnificationXref43
type: UnificationXref
id: 2445063
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445063

Replication Fork
type: PhysicalEntity
data source: Reactome
xref: UnificationXref26
xref: UnificationXref25
cellular location: nucleoplasm
comment: Reactome DB_ID: 169515

UnificationXref40
type: UnificationXref
id: Q92140
db: UniProt

UnificationXref41
type: UnificationXref
id: 2445056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445056

UnificationXref47
type: UnificationXref
id: REACT_150779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150779.1

UnificationXref46
type: UnificationXref
id: 2445058
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445058

UnificationXref45
type: UnificationXref
id: Q7ZWS7
db: UniProt

UnificationXref44
type: UnificationXref
id: REACT_150825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150825.1

UnificationXref49
type: UnificationXref
id: 2445062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445062

UnificationXref48
type: UnificationXref
id: Q7ZYM9
db: UniProt

cdk1-b
type: ProteinReference
name: cdc2x1.2
name: UniProt:P24033 cdk1-b
name: cdc2
xref: UnificationXref109
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.CATALYTIC ACTIVITY ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.PTM Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SIMILARITY Contains 1 protein kinase domain.
organism: Xenopus laevis

Xenopus unwinding complex at replication fork
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry29
component stoichiometry: Stoichiometry28
component stoichiometry: Stoichiometry31
component stoichiometry: Stoichiometry30
component: xGINS complex
component: xMcm8
component: xCdc45
component: Replication Fork
xref: UnificationXref150
xref: UnificationXref151
cellular location: nucleoplasm
comment: Reactome DB_ID: 176972

xGINS complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry27
component stoichiometry: Stoichiometry25
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry24
component: xPSF3p
component: xSLD5P
component: xPSF2p
component: xPSF1p
xref: UnificationXref146
xref: UnificationXref145
cellular location: nucleoplasm
comment: Reactome DB_ID: 176953

UniProt:Q6GQG3 arpp19-b
type: ProteinReference
name: arpp19-b
xref: UnificationXref62
comment: SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

capg
type: ProteinReference
name: ncapg
name: UniProt:Q9YHB5 ncapg
xref: UnificationXref80
comment: SIMILARITY Belongs to the CND3 (condensin subunit 3) family.SIMILARITY Contains 10 HEAT repeats.
organism: Xenopus laevis

Cerberus:Nodal
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component stoichiometry: Stoichiometry1
component: NODAL_XENLA
component: CER1_XENLA
xref: UnificationXref9
xref: UnificationXref10
cellular location: extracellular region
comment: Reactome DB_ID: 1181343

p-S67-Ensa/p-S67-Arpp19:PP2A-Ppp2r2d
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry7
component stoichiometry: Stoichiometry6
component: p-S67-Ensa/p-S67-Arpp19
component: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
xref: UnificationXref70
xref: UnificationXref69
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445084

Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry5
component stoichiometry: Stoichiometry4
component stoichiometry: Stoichiometry3
component: PP2A-subunit A
component: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
component: PP2A-catalytic subunit C
name: PP2A complex (containing Ppp2r2d)
xref: UnificationXref53
xref: UnificationXref54
cellular location: nucleoplasm
display name: PP2A-Ppp2r2d
comment: Reactome DB_ID: 2445055

Smc2:Smc4:p-T1314,1348,1353-Ncapd2:Ncaph:Ncapg
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry15
component stoichiometry: Stoichiometry16
component stoichiometry: Stoichiometry17
component stoichiometry: Stoichiometry18
component stoichiometry: Stoichiometry19
component: XCAP-E
component: Structural maintenance of chromosomes protein 4
component: p-xCAP-G
component: p-xCAP-H
component: p-T1314,1348,1353-XCAP-D2
xref: UnificationXref105
xref: UnificationXref104
cellular location: cytosol
display name: p-Condensin I
comment: Reactome DB_ID: 2520849

Smc2:Smc4:Ncapd2:Ncapg:Ncaph
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry9
component stoichiometry: Stoichiometry11
component stoichiometry: Stoichiometry10
component stoichiometry: Stoichiometry13
component stoichiometry: Stoichiometry12
component: XCAP-D2
component: XCAP-E
component: Structural maintenance of chromosomes protein 4
component: Condensin complex subunit 3
component: Condensin complex subunit 2
xref: UnificationXref93
xref: UnificationXref92
cellular location: cytosol
display name: Condensin I
comment: Reactome DB_ID: 2520852

Wnt11:Fzd7a
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry23
component stoichiometry: Stoichiometry22
component: Wnt11
component: Fzd7a
xref: UnificationXref133
xref: UnificationXref132
cellular location: plasma membrane
comment: Reactome DB_ID: 4568830

p-T161-Cdk1:Ccnb
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry21
component stoichiometry: Stoichiometry20
component: Ccnb
component: p-T161-Cdk1
xref: UnificationXref123
xref: UnificationXref122
cellular location: cytosol
display name: MPF
comment: Reactome DB_ID: 2520869

wnt11r
type: ProteinReference
name: UniProt:Q670P5 wnt11
name: wnt11
xref: UnificationXref126
comment: SIMILARITY Belongs to the Wnt family.
organism: Xenopus laevis

prkca
type: ProteinReference
name: prkca-prov
name: UniProt:Q6AZF7
xref: UnificationXref157
comment: CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
organism: Xenopus laevis

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref74

ppp2cb
type: ProteinReference
name: UniProt:Q92140
name: Ppp2cb
xref: UnificationXref40
comment: CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
organism: Xenopus laevis

http://identifiers.org/pubmed/10067895
type: PublicationXref
id: 10067895
author: De Robertis, EM
author: Piccolo, S
author: Agius, E
author: Leyns, L
author: Grunz, H
author: Bouwmeester, T
author: Bhattacharyya, S
db: Pubmed
title: The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
source: Nature 397:707-10
year: 1999

RelationshipXref2
type: RelationshipXref
id: 169494
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169494

RelationshipXref1
type: RelationshipXref
id: GO:0004386
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

arpp19
type: ProteinReference
name: arpp19-a
name: UniProt:Q6DEB4 arpp19-a
xref: UnificationXref59
comment: SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

RelationshipXref3
type: RelationshipXref
id: GO:0004693
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref4
type: RelationshipXref
id: 2520875
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520875

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref1

trpc1
type: ProteinReference
name: trp1
name: UniProt:Q9PRI8
xref: UnificationXref14
organism: Xenopus laevis

capd2
type: ProteinReference
name: ncapd2
name: cnap1
name: eg7
name: UniProt:Q9YHY6 ncapd2
xref: UnificationXref83
comment: SIMILARITY Belongs to the CND1 (condensin subunit 1) family.
organism: Xenopus laevis

UnificationXref101
type: UnificationXref
id: REACT_152009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152009.1

UnificationXref102
type: UnificationXref
id: 2520836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520836

UnificationXref100
type: UnificationXref
id: 2520847
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520847

UnificationXref105
type: UnificationXref
id: REACT_152425
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152425.1

UnificationXref106
type: UnificationXref
id: P35567
db: UniProt

UnificationXref103
type: UnificationXref
id: REACT_150584
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150584.1

UnificationXref104
type: UnificationXref
id: 2520849
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520849

UnificationXref109
type: UnificationXref
id: P24033
db: UniProt

UnificationXref107
type: UnificationXref
id: 2520863
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520863

ensa
type: ProteinReference
name: UniProt:Q7ZXH9 ensa
xref: UnificationXref55
comment: SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

UnificationXref108
type: UnificationXref
id: REACT_151951
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151951.1

cdc45
type: ProteinReference
name: cdc45l
name: UniProt:Q9YHZ6 cdc45
xref: UnificationXref147
comment: SIMILARITY Belongs to the CDC45 family.
organism: Xenopus laevis

UnificationXref114
type: UnificationXref
id: P13350
db: UniProt

UnificationXref115
type: UnificationXref
id: 2520868
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520868

UnificationXref116
type: UnificationXref
id: REACT_152471
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152471.1

UnificationXref117
type: UnificationXref
id: P13351
db: UniProt

UnificationXref110
type: UnificationXref
id: 2520864
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520864

UnificationXref111
type: UnificationXref
id: REACT_150661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150661.1

UnificationXref112
type: UnificationXref
id: 2520866
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520866

UnificationXref113
type: UnificationXref
id: REACT_151094
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151094.1

UnificationXref118
type: UnificationXref
id: 2520867
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520867

UnificationXref119
type: UnificationXref
id: REACT_150623
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150623.1

UnificationXref120
type: UnificationXref
id: 2520859
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520859

UnificationXref127
type: UnificationXref
id: 3965362
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3965362

UnificationXref128
type: UnificationXref
id: REACT_173465
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173465.1

UnificationXref125
type: UnificationXref
id: REACT_150138
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150138.2

UnificationXref126
type: UnificationXref
id: Q670P5
db: UniProt

UnificationXref123
type: UnificationXref
id: REACT_151167
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151167.1

UnificationXref124
type: UnificationXref
id: 2520871
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520871

UnificationXref121
type: UnificationXref
id: REACT_150805
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150805.1

UnificationXref122
type: UnificationXref
id: 2520869
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520869

UnificationXref129
type: UnificationXref
id: Q9PUK8
db: UniProt

http://identifiers.org/pubmed/10862746
type: PublicationXref
id: 10862746
author: Shi, De-Li
author: Riou, Jean-François
author: Boucaut, Jean-Claude
author: Djiane, Alexandre
author: Umbhauer, Muriel
db: Pubmed
title: Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
source: Development 127:3091-100
year: 2000

http://identifiers.org/pubmed/15707891
type: PublicationXref
id: 15707891
author: Danis, E
author: Mechali, M
author: Cuvier, O
author: Maiorano, D
db: Pubmed
title: MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
source: Cell 120:315-28
year: 2005

UnificationXref131
type: UnificationXref
id: REACT_173397
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173397.1

UnificationXref130
type: UnificationXref
id: 4568819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4568819

Reactome
type: Provenance
comment: http://www.reactome.org

xPSF1p
type: Protein
entity reference: gins2
data source: Reactome
xref: UnificationXref139
xref: UnificationXref140
cellular location: nucleoplasm
comment: Reactome DB_ID: 176946

xCdc45
type: Protein
entity reference: cdc45
data source: Reactome
xref: UnificationXref148
xref: UnificationXref149
cellular location: nucleoplasm
comment: Reactome DB_ID: 176954

Wnt11
type: Protein
entity reference: wnt11r
data source: Reactome
xref: UnificationXref127
xref: UnificationXref128
feature: FragmentFeature23
cellular location: extracellular region
comment: Reactome DB_ID: 3965362

Fzd7a
type: Protein
entity reference: fz7-a
data source: Reactome
xref: UnificationXref131
xref: UnificationXref130
feature: FragmentFeature24
cellular location: plasma membrane
comment: Reactome DB_ID: 4568819

kif15-a
type: Protein
entity reference: klp2
data source: Reactome
name: KI15A_XENLA
xref: UnificationXref173
xref: UnificationXref174
cellular location: cytosol
comment: Reactome DB_ID: 984841
display name: Xklp2

prkca
type: Protein
entity reference: prkca
data source: Reactome
xref: UnificationXref159
xref: UnificationXref158
feature: FragmentFeature25
cellular location: cytosol
comment: Reactome DB_ID: 4332328

prkca
type: Protein
entity reference: prkca
data source: Reactome
xref: UnificationXref166
xref: UnificationXref167
feature: FragmentFeature26
cellular location: plasma membrane
comment: Reactome DB_ID: 4332325

http://identifiers.org/pubmed/10395542
type: PublicationXref
id: 10395542
author: Sheldahl, Laird C
author: Malbon, Craig C
author: Moon, Randall T
author: Park, Maiyon
db: Pubmed
title: Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner
source: Curr. Biol. 9:695-8
year: 1999

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref31

1,2-Diacylglycerol
type: SmallMolecule
entity reference: D-1,2-Diacylglycerol
data source: Reactome
xref: UnificationXref161
xref: UnificationXref162
cellular location: plasma membrane
comment: Reactome DB_ID: 114519
display name: DAG

3-O-sn-Phosphatidyl-L-serine
type: SmallMolecule
entity reference: phosphatidyl-L-serine
data source: Reactome
name: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine
name: Phosphatidyl-L-serine
name: O3-Phosphatidyl-L-serine
xref: UnificationXref165
xref: UnificationXref164
cellular location: plasma membrane
comment: Reactome DB_ID: 33625
display name: Phosphatidylserine

http://identifiers.org/pubmed/16483939
type: PublicationXref
id: 16483939
author: Pacek, M
author: Kubota, Y
author: Takisawa, H
author: Tutter, AV
author: Walter, JC
db: Pubmed
title: Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication
source: Mol Cell 21:581-7
year: 2006

O-phospho-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref56

O-phospho-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref97

diacylglycerols
type: SmallMolecule
entity reference: diacylglycerols
data source: Reactome
name: DAGs
xref: UnificationXref19
xref: UnificationXref18
cellular location: plasma membrane
comment: Reactome DB_ID: 112275
display name: DAG

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref76
xref: UnificationXref75
cellular location: cytosol
comment: Reactome DB_ID: 113592
display name: ATP

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref96
xref: UnificationXref95
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

Calcium
type: SmallMolecule
entity reference: Calcium
data source: Reactome
xref: UnificationXref156
xref: UnificationXref155
cellular location: cytosol
comment: Reactome DB_ID: 74016
display name: Ca2+

NODAL_XENLA
type: Protein
entity reference: nodal
data source: Reactome
xref: UnificationXref8
xref: UnificationXref7
feature: FragmentFeature2
cellular location: extracellular region
comment: Reactome DB_ID: 1181119
display name: nodal

CER1_XENLA
type: Protein
entity reference: UniProt:P70041 cer1
data source: Reactome
xref: UnificationXref5
xref: UnificationXref4
feature: FragmentFeature1
cellular location: extracellular region
comment: Reactome DB_ID: 1181319
display name: cer1

XCAP-D2
type: Protein
entity reference: capd2
data source: Reactome
name: Condensin complex subunit 1
xref: UnificationXref85
xref: UnificationXref84
feature: FragmentFeature13
cellular location: cytosol
comment: Reactome DB_ID: 2520855
display name: Ncapd2

XCAP-E
type: Protein
entity reference: UniProt:P50533 smc2
data source: Reactome
name: Structural maintenance of chromosomes protein 2
xref: UnificationXref87
xref: UnificationXref88
feature: FragmentFeature14
cellular location: cytosol
comment: Reactome DB_ID: 2520844
display name: Smc2

Structural maintenance of chromosomes protein 4
type: Protein
entity reference: capc
data source: Reactome
name: XCAP-C
xref: UnificationXref79
xref: UnificationXref78
feature: FragmentFeature11
cellular location: cytosol
comment: Reactome DB_ID: 2520839
display name: Smc4

Condensin complex subunit 3
type: Protein
entity reference: capg
data source: Reactome
name: xCAP-G
xref: UnificationXref81
xref: UnificationXref82
feature: FragmentFeature12
cellular location: cytosol
comment: Reactome DB_ID: 2520848
display name: Ncapg

p-S67-cAMP-regulated phosphoprotein 19-A
type: Protein
entity reference: arpp19
data source: Reactome
name: p-S67-Arpp19-a
xref: UnificationXref61
xref: UnificationXref60
feature: ModificationFeature2
feature: FragmentFeature9
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445076
display name: p-S67-Arpp19

p-S67-cAMP-regulated phosphoprotein 19-B
type: Protein
entity reference: UniProt:Q6GQG3 arpp19-b
data source: Reactome
xref: UnificationXref63
xref: UnificationXref64
feature: ModificationFeature3
feature: FragmentFeature10
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445075
display name: p-S67-Arpp19-b

p-S67-Alpha-endosulfine
type: Protein
entity reference: ensa
data source: Reactome
xref: UnificationXref58
xref: UnificationXref57
feature: ModificationFeature1
feature: FragmentFeature8
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445079
display name: p-S67-Ensa

p-S67-Arpp19
type: Protein
data source: Reactome
member physical entity: p-S67-cAMP-regulated phosphoprotein 19-A
member physical entity: p-S67-cAMP-regulated phosphoprotein 19-B
xref: UnificationXref65
xref: UnificationXref66
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445082
comment: Converted from EntitySet in Reactome

Ppp2r1a
type: Protein
entity reference: ppp2r1a
data source: Reactome
xref: UnificationXref47
xref: UnificationXref46
feature: FragmentFeature6
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445058

Ppp2r1b
type: Protein
entity reference: ppp2r1b
data source: Reactome
xref: UnificationXref49
xref: UnificationXref50
feature: FragmentFeature7
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445062

Ppp2ca
type: Protein
entity reference: ppp2ca
data source: Reactome
xref: UnificationXref38
xref: UnificationXref39
feature: FragmentFeature4
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445067

Ppp2cb
type: Protein
entity reference: ppp2cb
data source: Reactome
xref: UnificationXref42
xref: UnificationXref41
feature: FragmentFeature5
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445056

PP2A-subunit A
type: Protein
data source: Reactome
member physical entity: Ppp2r1a
member physical entity: Ppp2r1b
xref: UnificationXref51
xref: UnificationXref52
cellular location: nucleoplasm
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2445065

TRPC1_Xenopus
type: Protein
entity reference: trpc1
data source: Reactome
xref: UnificationXref15
xref: UnificationXref16
cellular location: plasma membrane
comment: Reactome DB_ID: 622401
display name: xtrpc1

Ccnb
type: Protein
data source: Reactome
member physical entity: G2/mitotic-specific cyclin-B1
member physical entity: G2/mitotic-specific cyclin-B2
xref: UnificationXref121
xref: UnificationXref120
cellular location: cytosol
comment: Reactome DB_ID: 2520859
comment: Converted from EntitySet in Reactome

Activated xtrpc1
type: Protein
entity reference: trpc1
data source: Reactome
xref: UnificationXref20
xref: UnificationXref21
cellular location: plasma membrane
comment: Reactome DB_ID: 622399

G2/mitotic-specific cyclin-B1
type: Protein
entity reference: UniProt:P13350 ccnb1
data source: Reactome
xref: UnificationXref115
xref: UnificationXref116
feature: FragmentFeature21
cellular location: cytosol
comment: Reactome DB_ID: 2520868
display name: Ccnb1

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: Protein
entity reference: ppp2r2d
data source: Reactome
name: pp2a subunit B isoform B55-delta
xref: UnificationXref36
xref: UnificationXref35
feature: FragmentFeature3
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445064
display name: Ppp2r2d

G2/mitotic-specific cyclin-B2
type: Protein
entity reference: ccnb2
data source: Reactome
xref: UnificationXref118
xref: UnificationXref119
feature: FragmentFeature22
cellular location: cytosol
comment: Reactome DB_ID: 2520867
display name: Ccnb2

PP2A-catalytic subunit C
type: Protein
data source: Reactome
member physical entity: Ppp2ca
member physical entity: Ppp2cb
xref: UnificationXref44
xref: UnificationXref43
cellular location: nucleoplasm
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2445063

p-xCAP-G
type: Protein
entity reference: capg
data source: Reactome
xref: UnificationXref102
xref: UnificationXref103
feature: ModificationFeature8
feature: FragmentFeature18
cellular location: cytosol
comment: Reactome DB_ID: 2520836
display name: p-Ncapg

p-T161-Cdk1
type: Protein
data source: Reactome
member physical entity: p-T161-Cdk1-A
member physical entity: p-T161-Cdk1-B
xref: UnificationXref112
xref: UnificationXref113
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2520866

p-T161-Cdk1-A
type: Protein
entity reference: cdc2x1.1
data source: Reactome
xref: UnificationXref107
xref: UnificationXref108
feature: ModificationFeature9
feature: FragmentFeature19
cellular location: cytosol
comment: Reactome DB_ID: 2520863

p-T161-Cdk1-B
type: Protein
entity reference: cdk1-b
data source: Reactome
xref: UnificationXref110
xref: UnificationXref111
feature: FragmentFeature20
feature: ModificationFeature10
cellular location: cytosol
comment: Reactome DB_ID: 2520864

Condensin complex subunit 2
type: Protein
entity reference: caph
data source: Reactome
name: xCAP-H
xref: UnificationXref91
xref: UnificationXref90
feature: FragmentFeature15
cellular location: cytosol
comment: Reactome DB_ID: 2520846
display name: Ncaph

p-xCAP-H
type: Protein
entity reference: caph
data source: Reactome
xref: UnificationXref98
xref: UnificationXref99
feature: FragmentFeature16
feature: ModificationFeature4
cellular location: cytosol
comment: Reactome DB_ID: 2520850
display name: p-Ncaph

p-T1314,1348,1353-XCAP-D2
type: Protein
entity reference: capd2
data source: Reactome
xref: UnificationXref101
xref: UnificationXref100
feature: ModificationFeature6
feature: ModificationFeature7
feature: FragmentFeature17
feature: ModificationFeature5
cellular location: cytosol
comment: Reactome DB_ID: 2520847
display name: p-T1314,1348,1353-Ncapd2