UnificationXref3010
type: UnificationXref
id: 6262702
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262702

UnificationXref3011
type: UnificationXref
id: 6262703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262703

UnificationXref3004
type: UnificationXref
id: 6262723
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262723

UnificationXref3003
type: UnificationXref
id: 6262722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262722

UnificationXref3002
type: UnificationXref
id: 6262721
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262721

UnificationXref3001
type: UnificationXref
id: 6262697
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262697

UnificationXref3008
type: UnificationXref
id: 6262700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262700

UniProt:Q6K4E8
type: ProteinReference
xref: UnificationXref22726
organism: http://identifiers.org/taxonomy/4530

UnificationXref3007
type: UnificationXref
id: 6262699
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262699

UnificationXref3006
type: UnificationXref
id: 6262698
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262698

UnificationXref3005
type: UnificationXref
id: 6262720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262720

UnificationXref3009
type: UnificationXref
id: 6262701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262701

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1206
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.2
xref: UnificationXref13058
xref: UnificationXref13059
left: L-Glutamine
left: Water
left: SmallMolecule5
left: SmallMolecule400
display name: UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule659
right: L-Glutaminic acid
right: SmallMolecule3
right: SmallMolecule6

dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1205
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.4
xref: UnificationXref13032
xref: UnificationXref13033
left: SmallMolecule6
left: SmallMolecule983
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule5
right: SmallMolecule982

dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1204
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.4
xref: UnificationXref13030
xref: UnificationXref13031
left: SmallMolecule5
left: SmallMolecule982
display name: phosphorylation of dUMP or TMP to dUDP or TDP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule983

(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1203
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.4
xref: UnificationXref13012
xref: UnificationXref13013
left: SmallMolecule6
left: SmallMolecule980
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule979
right: SmallMolecule5

(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1202
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.4
xref: UnificationXref13011
xref: UnificationXref13010
left: SmallMolecule979
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule980

(d)GDP + ADP <=> (d)GMP + ATP [GUK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1201
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.8
xref: UnificationXref12989
xref: UnificationXref12990
left: SmallMolecule977
left: SmallMolecule6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule976
right: SmallMolecule5

(d)GMP + ATP <=> (d)GDP + ADP [GUK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1200
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.8
xref: UnificationXref12987
xref: UnificationXref12988
left: SmallMolecule976
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule977
right: SmallMolecule6

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

http://identifiers.org/pubmed/11903050
type: PublicationXref
id: 11903050
author: MacMullen, CM
author: Smith, TJ
author: Poncz, M
author: Hsu, BY
author: Fang, J
author: Stanley, CA
db: Pubmed
title: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
source: Biochem J 363:81-7
year: 2002

UnificationXref3020
type: UnificationXref
id: REACT_261798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261798.1

UnificationXref3021
type: UnificationXref
id: 6279657
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279657

UnificationXref3022
type: UnificationXref
id: REACT_231074
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231074.1

UnificationXref3013
type: UnificationXref
id: 6262705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262705

UnificationXref3012
type: UnificationXref
id: 6262704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262704

UnificationXref3015
type: UnificationXref
id: 6262726
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262726

UnificationXref3014
type: UnificationXref
id: 6262724
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262724

UnificationXref3017
type: UnificationXref
id: 6279696
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279696

UnificationXref3016
type: UnificationXref
id: REACT_221906
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221906.2

UnificationXref3019
type: UnificationXref
id: 6279656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279656

UnificationXref3018
type: UnificationXref
id: REACT_243301
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243301.1

http://identifiers.org/pubmed/8774846
type: PublicationXref
id: 8774846
author: Cohen, P
author: Young, P R
author: Clifton, A D
db: Pubmed
title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
source: FEBS Lett. 392:209-14
year: 1996

http://identifiers.org/pubmed/8662638
type: PublicationXref
id: 8662638
author: Wilson, MP
author: Majerus, PW
db: Pubmed
title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
source: J Biol Chem 271:11904-10
year: 1996

Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1209
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13117
xref: UnificationXref13118
left: SmallMolecule986
left: Protein4963
display name: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule987
right: Water
right: Protein4970

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1207
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.2
xref: UnificationXref13074
xref: UnificationXref13073
left: L-Glutamine
left: Water
left: SmallMolecule5
left: SmallMolecule400
display name: UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule659
right: L-Glutaminic acid
right: SmallMolecule3
right: SmallMolecule6

Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1208
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13093
xref: UnificationXref13094
left: SmallMolecule986
left: Protein4954
display name: NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule987
right: Protein4955
right: Water

UnificationXref10800
type: UnificationXref
id: 6276042
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276042

UnificationXref10805
type: UnificationXref
id: 6276047
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276047

UnificationXref10806
type: UnificationXref
id: 6276048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276048

UnificationXref10807
type: UnificationXref
id: 6276049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276049

UnificationXref10808
type: UnificationXref
id: 6276050
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276050

UnificationXref10801
type: UnificationXref
id: 6276043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276043

UnificationXref10802
type: UnificationXref
id: 6276044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276044

UnificationXref10803
type: UnificationXref
id: 6276045
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276045

UnificationXref10804
type: UnificationXref
id: 6276046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276046

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

UnificationXref10810
type: UnificationXref
id: 6276052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276052

UnificationXref10811
type: UnificationXref
id: 6276053
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276053

UnificationXref10818
type: UnificationXref
id: 6276030
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276030

UnificationXref10819
type: UnificationXref
id: 6276031
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276031

UnificationXref10816
type: UnificationXref
id: 6276028
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276028

UnificationXref3000
type: UnificationXref
id: 6262696
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262696

UnificationXref10817
type: UnificationXref
id: 6276029
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276029

UnificationXref10814
type: UnificationXref
id: 6276026
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276026

UnificationXref10815
type: UnificationXref
id: 6276027
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276027

UnificationXref10812
type: UnificationXref
id: 6276054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276054

UnificationXref10813
type: UnificationXref
id: 6276055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276055

UnificationXref10809
type: UnificationXref
id: 6276051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276051

UniProt:Q6K4D2
type: ProteinReference
xref: UnificationXref3522
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4D1
type: ProteinReference
xref: UnificationXref3534
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/17322878
type: PublicationXref
id: 17322878
author: Citri, A
author: Yarden, Y
author: Amit, I
author: Jacob-Hirsch, J
author: Siwak, D
author: Segal, E
author: Lu, Y
author: Tarcic, G
author: Amariglio, N
author: Mills, GB
author: Katz, M
author: Shay, T
author: Vaisman, N
author: Lahad, J
author: Domany, E
author: Rechavi, G
author: Alon, U
author: Zhang, F
db: Pubmed
title: A module of negative feedback regulators defines growth factor signaling
source: Nat Genet 39:503-12
year: 2007

UnificationXref10824
type: UnificationXref
id: 6276056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276056

UnificationXref10823
type: UnificationXref
id: 6276035
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276035

UnificationXref10826
type: UnificationXref
id: 6276059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276059

UnificationXref10825
type: UnificationXref
id: 6276057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276057

UnificationXref10828
type: UnificationXref
id: 6276061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276061

UnificationXref10827
type: UnificationXref
id: REACT_222563
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222563.2

UnificationXref10829
type: UnificationXref
id: REACT_209190
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209190.2

UnificationXref10820
type: UnificationXref
id: 6276032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276032

UnificationXref10822
type: UnificationXref
id: 6276034
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276034

UnificationXref10821
type: UnificationXref
id: 6276033
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276033

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

UnificationXref10837
type: UnificationXref
id: 6275797
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275797

UnificationXref10836
type: UnificationXref
id: 6275796
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275796

UnificationXref10835
type: UnificationXref
id: 6275795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275795

UnificationXref10834
type: UnificationXref
id: 6275794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275794

UnificationXref10839
type: UnificationXref
id: 6275991
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275991

UnificationXref10838
type: UnificationXref
id: 6275989
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275989

SRP-dependent cotranslational protein targeting to membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1129
pathway component: BiochemicalReaction1126
pathway component: BiochemicalReaction1128
pathway component: BiochemicalReaction1127
evidence: Evidence1739
xref: UnificationXref18690
xref: UnificationXref18691
xref: RelationshipXref1484
pathway order: PathwayStep1714
pathway order: PathwayStep1716
pathway order: PathwayStep1715
pathway order: PathwayStep1717
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10833
type: UnificationXref
id: 6275793
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275793

UnificationXref10832
type: UnificationXref
id: 6275792
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275792

UnificationXref10831
type: UnificationXref
id: REACT_124222
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124222.1

UnificationXref10830
type: UnificationXref
id: 1806259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806259

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

Synthesis of PIPs at the ER membrane
type: Pathway
data source: Provenance1
pathway component: PI4P is dephosphorylated to PI by SACM1L at the ER membrane
pathway component: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
evidence: Evidence954
xref: RelationshipXref770
xref: UnificationXref10559
xref: UnificationXref10560
pathway order: PathwayStep940
pathway order: PathwayStep939
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10849
type: UnificationXref
id: 1806198
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806198

UnificationXref10846
type: UnificationXref
id: REACT_246226
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246226.1

UnificationXref10845
type: UnificationXref
id: 6276018
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276018

UnificationXref10848
type: UnificationXref
id: REACT_202889
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202889.2

UnificationXref10847
type: UnificationXref
id: 6280039
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280039

UnificationXref10842
type: UnificationXref
id: REACT_123880
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123880.1

UnificationXref10841
type: UnificationXref
id: 1806199
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806199

UnificationXref10844
type: UnificationXref
id: REACT_220988
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220988.2

UnificationXref10843
type: UnificationXref
id: 6275954
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275954

UnificationXref10840
type: UnificationXref
id: REACT_237921
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237921.1

http://identifiers.org/pubmed/7356336
type: PublicationXref
id: 7356336
author: Logue, EA
author: Fall, RR
author: Hector, ML
author: Cochran, BC
db: Pubmed
title: Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
source: Arch Biochem Biophys 199:28-36
year: 1980

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

UnificationXref10859
type: UnificationXref
id: 6275868
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275868

UnificationXref10858
type: UnificationXref
id: 6275865
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275865

UnificationXref10857
type: UnificationXref
id: 6275862
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275862

UnificationXref10856
type: UnificationXref
id: 6275860
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275860

UnificationXref10855
type: UnificationXref
id: 6275857
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275857

UnificationXref10854
type: UnificationXref
id: 6275854
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275854

UnificationXref10853
type: UnificationXref
id: 6275851
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275851

UnificationXref10852
type: UnificationXref
id: REACT_122302
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122302.1

UnificationXref10851
type: UnificationXref
id: 1806289
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806289

UnificationXref10850
type: UnificationXref
id: REACT_125283
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125283.1

http://identifiers.org/pubmed/8631325
type: PublicationXref
id: 8631325
author: Peng, HL
author: Chao, YC
author: Chang, HY
author: Duggleby, RG
author: Huang, JG
db: Pubmed
title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
source: Eur J Biochem 235:173-9
year: 1996

UnificationXref3089
type: UnificationXref
id: REACT_262803
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_262803.1

ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1121
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.5
xref: UnificationXref12285
xref: UnificationXref12284
left: Phosphate
left: Adenosine 5'-diphosphate
left: SmallMolecule877
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Ethylenesuccinic acid
right: SmallMolecule433
right: Adenosine 5'-triphosphate

Fumarate + H2O <=> (S)-Malate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1122
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.2
xref: UnificationXref12296
xref: UnificationXref12295
left: Water
left: SmallMolecule881
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule146

Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1119
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.52
xref: UnificationXref12270
xref: UnificationXref12269
left: Oxoglutaric acid
left: DPN
left: SmallMolecule433
display name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: SmallMolecule877
right: SmallMolecule666

GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1120
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.4
xref: UnificationXref12280
xref: UnificationXref12281
left: Phosphate
left: SmallMolecule879
left: SmallMolecule877
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Ethylenesuccinic acid
right: SmallMolecule880
right: SmallMolecule433

isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1117
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.41
xref: UnificationXref12230
xref: UnificationXref12231
left: SmallMolecule875
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: Oxoglutaric acid
right: NADH
right: SmallMolecule666

isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1118
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.42
xref: UnificationXref12242
xref: UnificationXref12241
left: SmallMolecule875
left: SmallMolecule859
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: Oxoglutaric acid
right: SmallMolecule857
right: SmallMolecule666

citrate <=> isocitrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1115
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.3
xref: UnificationXref12196
xref: UnificationXref12197
left: SmallMolecule398
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule875

isocitrate <=> citrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1116
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.3
xref: UnificationXref12198
xref: UnificationXref12199
left: SmallMolecule875
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule398

PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1111
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.2
xref: UnificationXref12166
xref: UnificationXref12165
participant stoichiometry: Stoichiometry1298
participant stoichiometry: Stoichiometry1306
left: Complex554
left: Adenosine 5'-triphosphate
display name: Inactivation of PDC by phosphorylation of PDC E1 alpha component
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: Complex559

Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1114
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.3.1
xref: UnificationXref12190
xref: UnificationXref12191
left: SmallMolecule551
left: SmallMolecule395
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule398
right: SmallMolecule433

UnificationXref10861
type: UnificationXref
id: 6275873
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275873

UnificationXref10862
type: UnificationXref
id: 6275875
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275875

UniProt:A2ZU70
type: ProteinReference
xref: UnificationXref21189
organism: http://identifiers.org/taxonomy/4530

UnificationXref10860
type: UnificationXref
id: 6275870
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275870

UnificationXref10865
type: UnificationXref
id: 6275883
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275883

UnificationXref10866
type: UnificationXref
id: 6275885
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275885

UnificationXref3090
type: UnificationXref
id: 29428
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29428

UnificationXref10863
type: UnificationXref
id: 6275878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275878

UnificationXref3091
type: UnificationXref
id: REACT_3913
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3913.3

UnificationXref10864
type: UnificationXref
id: 6275880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275880

UnificationXref3092
type: UnificationXref
id: D2K3B6
db: UniProt

UnificationXref10869
type: UnificationXref
id: 6275891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275891

UnificationXref3093
type: UnificationXref
id: 6272415
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272415

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

UnificationXref3094
type: UnificationXref
id: Q2QM00
db: UniProt

UnificationXref10867
type: UnificationXref
id: 6275887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275887

UnificationXref3095
type: UnificationXref
id: 6272417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272417

UnificationXref10868
type: UnificationXref
id: 6275889
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275889

UnificationXref3096
type: UnificationXref
id: 6272418
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272418

UnificationXref3097
type: UnificationXref
id: 6272419
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272419

UnificationXref3098
type: UnificationXref
id: 75165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75165

UnificationXref3099
type: UnificationXref
id: REACT_5340
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5340.1

(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1108
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.27
xref: UnificationXref12067
xref: UnificationXref12068
left: SmallMolecule247
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule332

Cytosolic PYR is transported to the mitochondrial matrix by MPC1:MPC2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1109
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12084
xref: UnificationXref12085
left: proton
left: SmallMolecule332
display name: PYR + H+ (cytosol) => PYR + H+ (mitochondrial matrix)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule873

Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1110
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12141
xref: UnificationXref12140
left: SmallMolecule873
left: DPN
left: SmallMolecule433
display name: pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule551
right: NADH
right: SmallMolecule666

Activation of PP2A by Xylulose-5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1093
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11995
xref: UnificationXref11994
left: Complex319
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex319

AMP binds to gamma subunit of AMP kinase heterotrimer
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1094
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12014
xref: UnificationXref12015
left: Complex543
left: SmallMolecule870
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex544

GCH1 reduces GTP to dihydroneopterin triphosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1103
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.16
xref: UnificationXref12043
xref: UnificationXref12042
left: SmallMolecule1
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule460
right: SmallMolecule871

Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1107
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.27
xref: UnificationXref12065
xref: UnificationXref12066
left: NADH
left: proton
left: SmallMolecule332
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule247
right: DPN

Gq alpha activates Phospholipase C beta
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1085
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11965
xref: UnificationXref11966
left: PhysicalEntity147
left: Complex537
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex538

Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1086
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11970
xref: UnificationXref11971
left: Water
left: SmallMolecule314
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule315
right: SmallMolecule869

ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1090
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11989
xref: UnificationXref11988
left: SmallMolecule6
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule5

UnificationXref10870
type: UnificationXref
id: 6275893
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275893

UnificationXref10871
type: UnificationXref
id: 6275896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275896

UnificationXref10872
type: UnificationXref
id: 6275897
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275897

UnificationXref10873
type: UnificationXref
id: 6275900
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275900

UnificationXref10874
type: UnificationXref
id: 6275828
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275828

UnificationXref10875
type: UnificationXref
id: 6275831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275831

UnificationXref10876
type: UnificationXref
id: 6275834
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275834

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

UnificationXref10877
type: UnificationXref
id: 6275836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275836

UnificationXref10878
type: UnificationXref
id: 6275838
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275838

UnificationXref10879
type: UnificationXref
id: 6275840
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275840

UnificationXref3068
type: UnificationXref
id: 6262905
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262905

UnificationXref3067
type: UnificationXref
id: 6262904
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262904

UniProt:Q6K3Z3
type: ProteinReference
xref: UnificationXref8991
organism: http://identifiers.org/taxonomy/4530

UnificationXref3069
type: UnificationXref
id: REACT_223331
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223331.2

UnificationXref10880
type: UnificationXref
id: 6275842
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275842

5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1146
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.5.3
xref: UnificationXref12442
xref: UnificationXref12441
left: L-Glutamine
left: Water
left: SmallMolecule5
left: SmallMolecule895
display name: FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule896

5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1147
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.3.1
xref: UnificationXref12447
xref: UnificationXref12446
left: SmallMolecule5
left: SmallMolecule896
display name: FGAM + ATP => AIR + ADP + Pi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule897

5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1144
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.13
xref: UnificationXref12422
xref: UnificationXref12421
left: SmallMolecule5
left: SmallMolecule892
left: SmallMolecule123
display name: 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule893

5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1145
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.2.2
xref: UnificationXref12429
xref: UnificationXref12430
left: SmallMolecule893
left: SmallMolecule894
display name: GAR + 10-Formyl-THF => FGAR + THF
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule454
right: SmallMolecule895

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1150
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.10
xref: UnificationXref12478
xref: UnificationXref12479
left: SmallMolecule901
display name: FAICAR => IMP + H2O
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule891

inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1151
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.205
xref: UnificationXref12494
xref: UnificationXref12493
left: Water
left: SmallMolecule891
left: DPN
display name: IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule902

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1148
conversion direction: LEFT_TO_RIGHT
EC number: 4.3.2.2
xref: UnificationXref12465
xref: UnificationXref12466
left: SmallMolecule898
display name: SAICAR => AICAR + Fumarate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule900
right: SmallMolecule899

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1149
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.2.3
xref: UnificationXref12476
xref: UnificationXref12477
left: SmallMolecule899
left: SmallMolecule894
display name: AICAR + 10-Formyl-THF => FAICAR + THF
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule901
right: SmallMolecule454

UnificationXref10887
type: UnificationXref
id: 6275983
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275983

UnificationXref10888
type: UnificationXref
id: REACT_203693
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203693.2

UnificationXref10885
type: UnificationXref
id: 6275915
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275915

UnificationXref10886
type: UnificationXref
id: REACT_210482
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210482.2

UnificationXref10883
type: UnificationXref
id: 6275848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275848

5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1143
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.14
xref: UnificationXref12409
xref: UnificationXref12410
left: SmallMolecule414
left: L-Glutamine
left: Water
display name: PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule340
right: SmallMolecule892

UnificationXref10884
type: UnificationXref
id: 6275901
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275901

Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1142
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12404
xref: UnificationXref12403
participant stoichiometry: Stoichiometry1345
left: Complex577
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex576

UnificationXref10881
type: UnificationXref
id: 6275844
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275844

UnificationXref10882
type: UnificationXref
id: 6275847
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275847

UnificationXref3074
type: UnificationXref
id: 6262910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262910

UnificationXref3075
type: UnificationXref
id: 6262911
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262911

UnificationXref3076
type: UnificationXref
id: REACT_219512
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219512.2

UnificationXref3077
type: UnificationXref
id: 6279735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279735

UnificationXref3070
type: UnificationXref
id: 6279737
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279737

UnificationXref3071
type: UnificationXref
id: REACT_258739
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258739.1

UnificationXref3072
type: UnificationXref
id: 176395
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176395

UnificationXref10889
type: UnificationXref
id: 1806212
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806212

UnificationXref3073
type: UnificationXref
id: REACT_8082
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8082.1

Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1141
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12396
xref: UnificationXref12395
participant stoichiometry: Stoichiometry1343
left: Complex576
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex577

UnificationXref3079
type: UnificationXref
id: 6263084
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263084

UnificationXref3078
type: UnificationXref
id: REACT_263296
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263296.1

(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1124
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.37
xref: UnificationXref12300
xref: UnificationXref12299
left: SmallMolecule146
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule395
right: NADH

(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1126
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.99.2
xref: UnificationXref12308
xref: UnificationXref12309
left: SmallMolecule554
left: SmallMolecule882
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxoglutaric acid
right: SmallMolecule556

UnificationXref10891
type: UnificationXref
id: 6275798
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275798

Reducing equivalents from beta-oxidation of fatty acids transfer to ETF
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1129
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12323
xref: UnificationXref12322
left: SmallMolecule556
left: Complex571
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule554
right: Complex572

UnificationXref10890
type: UnificationXref
id: REACT_125583
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125583.1

Transfer of electrons from ETF to ubiquinone by ETF-QO
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1130
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.5.1
xref: UnificationXref12332
xref: UnificationXref12333
left: SmallMolecule884
left: Complex572
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule885
right: Complex571

FA anion diffuses laterally to UCP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1132
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12358
xref: UnificationXref12357
left: SmallMolecule886
left: Complex573
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex574

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

FA anion flip-flops to the opposite surface
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1133
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12363
xref: UnificationXref12362
left: Complex574
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex575

The FA anion diffuses away laterally from UCP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1134
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12365
xref: UnificationXref12364
left: Complex575
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule887
right: Complex573

Protons are translocated from the intermembrane space to the matrix
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1136
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12370
xref: UnificationXref12371
left: SmallMolecule888
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+

UnificationXref10896
type: UnificationXref
id: REACT_239895
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239895.1

UnificationXref3080
type: UnificationXref
id: 6263085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263085

UnificationXref10897
type: UnificationXref
id: 1806195
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806195

UnificationXref10898
type: UnificationXref
id: REACT_125114
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125114.1

UnificationXref10899
type: UnificationXref
id: 6275903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275903

UnificationXref10892
type: UnificationXref
id: 6275799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275799

UnificationXref10893
type: UnificationXref
id: 6275800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275800

UnificationXref10894
type: UnificationXref
id: 6275801
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275801

(S)-Malate <=> Fumarate + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1123
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.2
xref: UnificationXref12297
xref: UnificationXref12298
left: SmallMolecule146
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule881

UnificationXref10895
type: UnificationXref
id: 6275986
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275986

UnificationXref3087
type: UnificationXref
id: REACT_239611
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239611.1

UnificationXref3088
type: UnificationXref
id: 6279734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279734

UnificationXref3085
type: UnificationXref
id: REACT_256941
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256941.1

UnificationXref3086
type: UnificationXref
id: 6279733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279733

UnificationXref3083
type: UnificationXref
id: REACT_230373
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230373.1

UnificationXref3084
type: UnificationXref
id: 6279732
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279732

UnificationXref3081
type: UnificationXref
id: REACT_214900
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_214900.2

UnificationXref3082
type: UnificationXref
id: 6279731
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279731

hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1175
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.1.23
xref: UnificationXref12773
xref: UnificationXref12772
left: Water
left: SmallMolecule942
display name: dUTP + H2O => dUMP + pyrophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule449
right: SmallMolecule943

deamination of dCMP to form dUMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1174
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.12
xref: UnificationXref12763
xref: UnificationXref12762
left: Water
left: SmallMolecule940
display name: dCMP + H2O => dUMP + NH4+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule941
right: SmallMolecule933

http://identifiers.org/pubmed/12700044
type: PublicationXref
id: 12700044
author: Maness, PF
author: Thelen, K
author: Panicker, AK
author: Buhusi, M
db: Pubmed
title: Cellular signalling mechanisms of neural cell adhesion molecules
source: Front Biosci 8:d900-11
year: 2003

decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1173
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.23
xref: UnificationXref12751
xref: UnificationXref12752
left: SmallMolecule939
display name: orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule258

orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1172
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.10
xref: UnificationXref12750
xref: UnificationXref12749
left: SmallMolecule414
left: SmallMolecule937
display name: phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule939
right: SmallMolecule340

(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1171
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.5.2
EC number: 1.3.99.11
xref: UnificationXref12738
xref: UnificationXref12739
left: SmallMolecule884
left: SmallMolecule936
display name: oxidation of (S)-Dihydroorotate to form Orotate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule885
right: SmallMolecule937

2 H2O2 => O2 + 2 H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1168
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.6
xref: UnificationXref12721
xref: UnificationXref12722
participant stoichiometry: Stoichiometry1376
participant stoichiometry: Stoichiometry1377
left: SmallMolecule568
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule566
right: SmallMolecule570

UnificationXref3045
type: UnificationXref
id: 6262906
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262906

UnificationXref3046
type: UnificationXref
id: REACT_226441
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226441.2

UnificationXref3047
type: UnificationXref
id: 6262902
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262902

UnificationXref3048
type: UnificationXref
id: 6262907
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262907

UnificationXref3049
type: UnificationXref
id: REACT_217629
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_217629.2

UnificationXref3051
type: UnificationXref
id: REACT_237316
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237316.1

UnificationXref3050
type: UnificationXref
id: 6279736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279736

UnificationXref3053
type: UnificationXref
id: REACT_8833
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8833.1

UnificationXref3052
type: UnificationXref
id: 176398
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176398

UnificationXref3055
type: UnificationXref
id: 6262903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262903

UnificationXref3054
type: UnificationXref
id: 6262892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262892

Hypoxanthine + H2O + O2 => Xanthine + H2O2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1166
conversion direction: LEFT_TO_RIGHT
EC number: 1.17.3.2
xref: UnificationXref12705
xref: UnificationXref12704
left: Water
left: SmallMolecule293
left: SmallMolecule925
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule440
right: SmallMolecule934

Xanthine + H2O + O2 => Urate + H2O2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1167
conversion direction: LEFT_TO_RIGHT
EC number: 1.17.3.2
xref: UnificationXref12707
xref: UnificationXref12706
left: Water
left: SmallMolecule293
left: SmallMolecule934
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule249
right: SmallMolecule440

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1164
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.5
xref: UnificationXref12687
xref: UnificationXref12688
left: Water
left: SmallMolecule927
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule929

Guanine + H2O => Xanthine + NH3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1165
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.3
xref: UnificationXref12698
xref: UnificationXref12699
left: Water
left: SmallMolecule924
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule934
right: SmallMolecule933

Adenine + PRPP => AMP + PPi
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1161
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.7
xref: UnificationXref12649
xref: UnificationXref12648
left: SmallMolecule414
left: SmallMolecule922
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule7

Deamination of N6-methyl-AMP to form IMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1160
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.4
xref: UnificationXref12623
xref: UnificationXref12624
left: Water
left: SmallMolecule920
display name: N6-methyl-AMP + H2O => IMP + methylamine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule891
right: SmallMolecule921

guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1162
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.8
xref: UnificationXref12661
xref: UnificationXref12662
left: SmallMolecule414
left: SmallMolecule923
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule926

deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1157
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12571
xref: UnificationXref12570
left: SmallMolecule5
left: SmallMolecule908
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule910

(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1156
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.20
xref: UnificationXref12549
xref: UnificationXref12548
left: SmallMolecule904
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule907

AMP + H2O => IMP + NH3 [AMPD]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1159
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.6
xref: UnificationXref12612
xref: UnificationXref12613
left: Water
left: SmallMolecule7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NH4+
right: SmallMolecule891

dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1158
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12596
xref: UnificationXref12595
left: SmallMolecule912
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule916

UnificationXref3058
type: UnificationXref
id: 6262894
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262894

UnificationXref3059
type: UnificationXref
id: REACT_207179
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207179.2

UnificationXref3056
type: UnificationXref
id: REACT_221202
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221202.2

UnificationXref3057
type: UnificationXref
id: 6262893
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262893

UnificationXref3062
type: UnificationXref
id: 6262908
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262908

UnificationXref3061
type: UnificationXref
id: 6262899
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262899

UnificationXref3060
type: UnificationXref
id: 6262898
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262898

UnificationXref3066
type: UnificationXref
id: REACT_8740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8740.1

UnificationXref3065
type: UnificationXref
id: 176397
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176397

UnificationXref3064
type: UnificationXref
id: 6262900
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262900

UnificationXref3063
type: UnificationXref
id: REACT_207223
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207223.2

http://identifiers.org/pubmed/15538381
type: PublicationXref
id: 15538381
author: Lu, M
author: Gherzi, R
author: Leuenberger, SA
author: Hemmings, BA
author: Stoecklin, G
author: Hess, D
author: Mallaun, M
author: Schmidlin, M
author: Moroni, C
author: Gross, B
db: Pubmed
title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
source: EMBO J 23:4760-9
year: 2004

xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1152
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.1
xref: UnificationXref12499
xref: UnificationXref12498
left: L-Glutamine
left: Water
left: SmallMolecule902
left: SmallMolecule5
display name: XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule275

inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1153
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.4
xref: UnificationXref12516
xref: UnificationXref12517
left: SmallMolecule1
left: SmallMolecule891
left: SmallMolecule170
display name: IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule2
right: SmallMolecule3
right: SmallMolecule903

adenylosuccinate => adenosine 5'-monophosphate + fumarate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1154
conversion direction: LEFT_TO_RIGHT
EC number: 4.3.2.2
xref: UnificationXref12523
xref: UnificationXref12522
left: SmallMolecule903
display name: Adenylosuccinate => AMP + Fumarate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule900
right: SmallMolecule7

(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1199
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12976
xref: UnificationXref12975
left: SmallMolecule6
left: SmallMolecule973
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule5
right: SmallMolecule972

DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry310
component stoichiometry: Stoichiometry313
component stoichiometry: Stoichiometry312
component stoichiometry: Stoichiometry311
component: Protein907
component: PhysicalEntity16
component: Protein902
component: Protein901
xref: UnificationXref1751
cellular location: GO_0005654
comment: Reactome DB_ID: 6254583

(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1198
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12974
xref: UnificationXref12973
left: SmallMolecule5
left: SmallMolecule972
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule973

ADP + ADP <=> AMP + ATP [AK2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1197
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.3
xref: UnificationXref12957
xref: UnificationXref12958
participant stoichiometry: Stoichiometry1404
left: SmallMolecule6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule5
right: SmallMolecule7

AMP + ATP <=> ADP + ADP [AK2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1196
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.3
xref: UnificationXref12955
xref: UnificationXref12956
participant stoichiometry: Stoichiometry1403
left: SmallMolecule5
left: SmallMolecule7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6

UnificationXref3027
type: UnificationXref
id: CHEBI:15986
db: ChEBI

UnificationXref3028
type: UnificationXref
id: 163085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=163085

UnificationXref3029
type: UnificationXref
id: REACT_8670
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8670.2

UnificationXref3023
type: UnificationXref
id: 6279339
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279339

UnificationXref3024
type: UnificationXref
id: REACT_234092
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234092.1

UnificationXref3025
type: UnificationXref
id: 6262886
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262886

UnificationXref3026
type: UnificationXref
id: 6262887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262887

UnificationXref3031
type: UnificationXref
id: 6262889
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262889

UnificationXref3030
type: UnificationXref
id: 6262888
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262888

UnificationXref3033
type: UnificationXref
id: 6262890
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262890

http://identifiers.org/pubmed/7635144
type: PublicationXref
id: 7635144
author: Squire, JA
author: Reck, F
author: Bendiak, B
author: Leong, P
author: Tan, J
author: D'Agostaro, AF
author: Schachter, H
author: Sarkar, M
db: Pubmed
title: The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein
source: Eur J Biochem 231:317-28
year: 1995

UnificationXref3032
type: UnificationXref
id: REACT_204821
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204821.2

thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1188
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.2
xref: UnificationXref12916
xref: UnificationXref12917
left: proton
left: SmallMolecule964
left: NADPH
display name: reduction of thymine to form 5,6-Dihydrothymine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule965

conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1189
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.2.2
xref: UnificationXref12921
xref: UnificationXref12922
left: Water
left: SmallMolecule965
display name: 5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule966

(d)AMP + ATP <=> (d)ADP + ADP [AK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1194
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.3
xref: UnificationXref12946
xref: UnificationXref12947
left: SmallMolecule5
left: SmallMolecule907
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule970

(d)ADP + ADP <=> (d)AMP + ATP [AK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1195
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.3
xref: UnificationXref12948
xref: UnificationXref12949
left: SmallMolecule6
left: SmallMolecule970
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule5
right: SmallMolecule907

beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1190
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1.6
xref: UnificationXref12926
xref: UnificationXref12927
left: Water
left: SmallMolecule966
display name: conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: NH4+
right: SmallMolecule967

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1191
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.40
xref: UnificationXref12933
xref: UnificationXref12934
left: SmallMolecule968
left: SmallMolecule873
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule969
right: SmallMolecule963

uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1184
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.2
xref: UnificationXref12869
xref: UnificationXref12868
left: proton
left: SmallMolecule957
left: NADPH
display name: reduction of uracil to form dihydrouracil
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule958
right: NADP+

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1183
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.5
xref: UnificationXref12858
xref: UnificationXref12857
left: Water
left: SmallMolecule954
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule955
right: SmallMolecule3

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1186
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1.6
xref: UnificationXref12887
xref: UnificationXref12888
left: SmallMolecule959
left: Water
display name: conversion of 3-ureidopropionate to beta-alanine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: NH4+
right: SmallMolecule960

conversion of 5,6-dihydrouracil to 3-ureidopropionate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1185
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.2.2
xref: UnificationXref12880
xref: UnificationXref12879
left: SmallMolecule958
left: Water
display name: 5,6-dihydrouracil + H2O => beta-ureidopropionate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule959

beta-alanine + pyruvate => 3-oxopropanoate + alanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1187
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.18
xref: UnificationXref12909
xref: UnificationXref12908
left: SmallMolecule961
left: SmallMolecule873
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule962
right: SmallMolecule963

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

UnificationXref3038
type: UnificationXref
id: 6262895
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262895

UnificationXref3039
type: UnificationXref
id: 6262909
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262909

UnificationXref3036
type: UnificationXref
id: 6279730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279730

UnificationXref3037
type: UnificationXref
id: REACT_252772
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252772.1

UnificationXref3034
type: UnificationXref
id: 6262891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262891

UnificationXref3035
type: UnificationXref
id: REACT_213409
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213409.2

UnificationXref3044
type: UnificationXref
id: 6262901
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262901

UnificationXref3043
type: UnificationXref
id: REACT_212400
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212400.2

UnificationXref3042
type: UnificationXref
id: 6262897
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262897

UnificationXref3041
type: UnificationXref
id: 6262896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6262896

UnificationXref3040
type: UnificationXref
id: REACT_213528
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213528.2

dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1176
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.1.45
xref: UnificationXref12787
xref: UnificationXref12786
left: SmallMolecule941
left: SmallMolecule454
display name: conversion of dUMP to dTMP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule945
right: SmallMolecule944

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1178
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12815
xref: UnificationXref12814
left: SmallMolecule5
left: SmallMolecule946
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule949

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1179
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12826
xref: UnificationXref12825
left: SmallMolecule5
left: SmallMolecule946
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule949

thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1180
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12833
xref: UnificationXref12834
left: SmallMolecule5
left: SmallMolecule950
display name: phosphorylation of 2'-Deoxythymidine to dTMP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule944

phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1181
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref12841
xref: UnificationXref12840
left: SmallMolecule5
left: SmallMolecule951
display name: (2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule953
right: SmallMolecule6

UniProt:Q6K4V9
type: ProteinReference
xref: UnificationXref9781
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/9712840
type: PublicationXref
id: 9712840
author: Kikuchi, Y
author: Mizutani, M
author: Katada, T
author: Imai, M
author: Hoshino, S
author: Hanaoka, F
author: Ui, M
db: Pubmed
title: Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.
source: J Biol Chem 273:22254-9
year: 1998

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1238
pathway component: BiochemicalReaction1239
pathway component: BiochemicalReaction1241
pathway component: BiochemicalReaction1240
evidence: Evidence1939
xref: UnificationXref20762
xref: UnificationXref20763
xref: RelationshipXref1604
pathway order: PathwayStep1915
pathway order: PathwayStep1916
pathway order: PathwayStep1913
pathway order: PathwayStep1914
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4T7
type: ProteinReference
xref: UnificationXref13750
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4T1
type: ProteinReference
xref: UnificationXref18270
organism: http://identifiers.org/taxonomy/4530

E2F mediated regulation of DNA replication
type: Pathway
data source: Provenance1
pathway component: TemplateReaction2
pathway component: REACT 249177.1
pathway component: REACT 239807.1
evidence: Evidence178
xref: UnificationXref2535
xref: UnificationXref2536
pathway order: PathwayStep171
pathway order: PathwayStep173
pathway order: PathwayStep166
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/12445824
type: PublicationXref
id: 12445824
author: Ganapathy, V
author: Inoue, K
author: Zhuang, L
db: Pubmed
title: Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function
source: Biochem Biophys Res Commun 299:465-71
year: 2002

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

herbimycin
type: SmallMoleculeReference
name: herbimycin [ChEBI:5674]
xref: UnificationXref6067

Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1210
conversion direction: LEFT_TO_RIGHT
EC number: 1.17.4.1
xref: UnificationXref13163
xref: UnificationXref13164
left: SmallMolecule988
left: Protein4977
display name: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule992
right: Protein4984
right: Water

http://identifiers.org/pubmed/7317031
type: PublicationXref
id: 7317031
author: Orford, C R
author: Scott, J E
db: Pubmed
title: Dermatan sulphate-rich proteoglycan associates with rat tail-tendon collagen at the d band in the gap region
source: Biochem. J. 197:213-6
year: 1981

glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1212
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.1.7
xref: UnificationXref13171
xref: UnificationXref13170
participant stoichiometry: Stoichiometry1419
left: proton
left: NADPH
left: SmallMolecule424
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule422

glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1211
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13165
xref: UnificationXref13166
left: Protein4955
left: SmallMolecule422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein4954
right: SmallMolecule424

thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1214
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.1.9
xref: UnificationXref13175
xref: UnificationXref13176
left: proton
left: Protein4970
left: NADPH
display name: regeneration of active (reduced) Thioredoxin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein4963
right: NADP+

thioredoxin, oxidized (nucleus) <=> thioredoxin, oxidized (cytosol)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1213
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13173
xref: UnificationXref13172
left: Protein4984
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein4970

(d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1216
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.6
xref: UnificationXref13196
xref: UnificationXref13195
left: SmallMolecule5
left: SmallMolecule998
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule999

thioredoxin, reduced (cytosol) <=> thioredoxin, reduced (nucleus)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1215
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13178
xref: UnificationXref13177
left: Protein4963
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein4977

(d)NDP + ATP <=> (d)NTP + ADP [NME4]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1218
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.6
xref: UnificationXref13232
xref: UnificationXref13231
left: SmallMolecule1004
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule1012

(d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1217
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.6
xref: UnificationXref13198
xref: UnificationXref13197
left: SmallMolecule6
left: SmallMolecule999
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule5
right: SmallMolecule998

(d)NTP + ADP <=> (d)NDP + ATP [NME4]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1219
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.4.6
xref: UnificationXref13234
xref: UnificationXref13233
left: Adenosine 5'-diphosphate
left: SmallMolecule1012
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1004
right: Adenosine 5'-triphosphate

alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1228
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.2
xref: UnificationXref13271
xref: UnificationXref13272
left: Oxoglutaric acid
left: SmallMolecule963
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule873
right: L-Glutaminic acid

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1227
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.2
xref: UnificationXref13268
xref: UnificationXref13267
left: L-Glutaminic acid
left: SmallMolecule332
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule235
right: SmallMolecule113

alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1226
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.2
xref: UnificationXref13266
xref: UnificationXref13265
left: SmallMolecule235
left: SmallMolecule113
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule332

ITPA hydrolyses XTP to XMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1223
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13255
xref: UnificationXref13256
left: Water
left: SmallMolecule1021
display name: XTP + H2O => XMP + PPi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule902
right: SmallMolecule340

Disease
type: Pathway
data source: Provenance1
pathway component: REACT 216765.2
pathway component: REACT 177537.3
pathway component: REACT 212772.2
pathway component: REACT 216580.2
pathway component: REACT 175840.3
pathway component: REACT 210191.2
pathway component: REACT 215045.2
pathway component: REACT 177423.3
pathway component: REACT 237956.1
pathway component: Signaling by FGFR in disease
pathway component: REACT 177549.3
pathway component: REACT 255493.1
evidence: Evidence700
xref: UnificationXref8122
xref: UnificationXref8123
pathway order: PathwayStep416
pathway order: PathwayStep528
pathway order: PathwayStep527
pathway order: PathwayStep512
pathway order: PathwayStep606
pathway order: PathwayStep468
pathway order: PathwayStep683
pathway order: PathwayStep530
pathway order: PathwayStep450
pathway order: PathwayStep448
pathway order: PathwayStep472
pathway order: PathwayStep688
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

ITPA hydrolyses dITP to dIMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1222
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13249
xref: UnificationXref13250
left: Water
left: SmallMolecule1020
display name: dITP + H2O => dIMP + PPi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule928
right: SmallMolecule340

ITPA hydrolyses ITP to IMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1221
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13244
xref: UnificationXref13243
left: SmallMolecule1019
left: Water
display name: ITP + H2O => IMP + PPi
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule891

ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1232
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.13
xref: UnificationXref13288
xref: UnificationXref13289
left: Oxoglutaric acid
left: SmallMolecule1022
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule1023

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1231
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.1
xref: UnificationXref13277
xref: UnificationXref13278
left: Oxoglutaric acid
left: SmallMolecule396
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule395
right: L-Glutaminic acid

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1230
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.1
xref: UnificationXref13275
xref: UnificationXref13276
left: L-Glutaminic acid
left: SmallMolecule329
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule235
right: SmallMolecule170

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1229
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.2
xref: UnificationXref13273
xref: UnificationXref13274
left: SmallMolecule873
left: L-Glutaminic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxoglutaric acid
right: SmallMolecule963

UniProt:Q6K4W2
type: ProteinReference
xref: UnificationXref16139
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/18555778
type: PublicationXref
id: 18555778
author: Aarden, Lucien A
author: Mooi, Wolter J
author: Vredeveld, Liesbeth C W
author: Michaloglou, Chrysiis
author: Peeper, Daniel S
author: Douma, Sirith
author: Desmet, Christophe J
author: Kuilman, Thomas
author: van Doorn, Remco
db: Pubmed
title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
source: Cell 133:1019-31
year: 2008

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1237
conversion direction: LEFT_TO_RIGHT
EC number: 1.4.1.3
xref: UnificationXref13345
xref: UnificationXref13344
left: H+
left: Oxoglutaric acid
left: SmallMolecule1026
left: SmallMolecule1027
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1028
right: Water
right: L-Glutaminic acid

http://identifiers.org/pubmed/18555777
type: PublicationXref
id: 18555777
author: Augert, Arnaud
author: Popov, Nikolay
author: Takatsu, Yoshihiro
author: Gil, Jesús
author: Acosta, Juan C
author: Banito, Ana
author: Da Costa, Marco
author: Melamed, Jonathan
author: Guijarro, Maria V
author: Raguz, Selina
author: Fumagalli, Marzia
author: Brown, Celia
author: O'Loghlen, Ana
author: Hernando, Eva
author: d'Adda di Fagagna, Fabrizio
author: Bernard, David
db: Pubmed
title: Chemokine signaling via the CXCR2 receptor reinforces senescence
source: Cell 133:1006-18
year: 2008

aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1236
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.5.4
xref: UnificationXref13326
xref: UnificationXref13327
left: L-Glutamine
left: Water
left: SmallMolecule5
left: SmallMolecule170
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule114

glutamine + pyruvate => 2-oxoglutaramate + alanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1239
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.15
xref: UnificationXref13356
xref: UnificationXref13355
left: L-Glutamine
left: SmallMolecule332
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1029
right: SmallMolecule113

glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1238
conversion direction: LEFT_TO_RIGHT
EC number: 1.4.1.3
xref: UnificationXref13349
xref: UnificationXref13348
left: SmallMolecule1028
left: Water
left: L-Glutaminic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: Oxoglutaric acid
right: SmallMolecule1026
right: SmallMolecule1027

glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1233
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.13
xref: UnificationXref13291
xref: UnificationXref13290
left: L-Glutaminic acid
left: SmallMolecule1023
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxoglutaric acid
right: SmallMolecule1022

L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1235
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.1.2
xref: UnificationXref13318
xref: UnificationXref13319
left: H+
left: SmallMolecule1024
left: SmallMolecule857
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1025
right: SmallMolecule859

glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1234
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13303
xref: UnificationXref13304
left: H+
left: SmallMolecule857
left: L-Glutaminic acid
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Adenosine 5'-diphosphate
right: SmallMolecule1023
right: SmallMolecule859

3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1241
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.52
xref: UnificationXref13391
xref: UnificationXref13390
left: L-Glutaminic acid
left: SmallMolecule1030
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule235
right: SmallMolecule1031

3-phosphoglycerate is dehydrogenated
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1240
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.95
xref: UnificationXref13382
xref: UnificationXref13383
left: SmallMolecule391
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule1030

phosphoserine is dephosphorylated
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1242
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.3
xref: UnificationXref13401
xref: UnificationXref13400
left: Water
left: SmallMolecule1031
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule116

SequenceSite16008
type: SequenceSite
position status: EQUAL
sequence position: 725

SequenceSite16007
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16009
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16004
type: SequenceSite
position status: EQUAL
sequence position: 725

SequenceSite16003
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16006
type: SequenceSite
position status: EQUAL
sequence position: 725

SequenceSite16005
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

SequenceSite16000
type: SequenceSite
position status: EQUAL
sequence position: 706

SequenceSite16002
type: SequenceSite
position status: EQUAL
sequence position: 706

SequenceSite16001
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q6K4N6
type: ProteinReference
xref: UnificationXref3183
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4N7
type: ProteinReference
xref: UnificationXref3189
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4N0
type: ProteinReference
xref: UnificationXref21217
organism: http://identifiers.org/taxonomy/4530

SequenceSite16014
type: SequenceSite
position status: EQUAL
sequence position: 673

SequenceSite16013
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16012
type: SequenceSite
position status: EQUAL
sequence position: 673

SequenceSite16011
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16010
type: SequenceSite
position status: EQUAL
sequence position: 673

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

UniProt:Q6K4K9
type: ProteinReference
xref: UnificationXref2298
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/11851405
type: PublicationXref
id: 11851405
author: Lin, Zheng
author: Liu, Alice Y-C
author: Manalo, Dominador J
db: Pubmed
title: Redox-dependent regulation of the conformation and function of human heat shock factor 1
source: Biochemistry 41:2580-8
year: 2002

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

UniProt:Q6K4Q0
type: ProteinReference
xref: UnificationXref17591
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4P2
type: ProteinReference
xref: UnificationXref18369
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K4P1
type: ProteinReference
xref: UnificationXref18371
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/18367646
type: PublicationXref
id: 18367646
author: Ji, JY
author: Herr, A
author: Longworth, Michelle
author: Dyson, NJ
db: Pubmed
title: RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
source: Genes Dev 22:1011-24
year: 2008

UniProt:Q6K4P5
type: ProteinReference
xref: UnificationXref17016
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/3931076
type: PublicationXref
id: 3931076
author: Wogan, G N
author: Zhu, J Q
author: Chen, J S
author: Groopman, J D
author: Donahue, P R
db: Pubmed
title: Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography
source: Proc. Natl. Acad. Sci. U.S.A. 82:6492-6
year: 1985

UnificationXref3110
type: UnificationXref
id: 6263106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263106

UniProt:Q2QM98
type: ProteinReference
xref: UnificationXref18641
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QM93
type: ProteinReference
xref: UnificationXref9117
organism: http://identifiers.org/taxonomy/4530

UniProt:A2ZV22
type: ProteinReference
xref: UnificationXref3169
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QM94
type: ProteinReference
xref: UnificationXref9125
organism: http://identifiers.org/taxonomy/4530

UnificationXref3109
type: UnificationXref
id: 6263105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263105

UnificationXref3108
type: UnificationXref
id: REACT_176563
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176563.3

UnificationXref3107
type: UnificationXref
id: 6279340
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279340

UniProt:Q6K3A5
type: ProteinReference
xref: UnificationXref18831
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/21356517
type: PublicationXref
id: 21356517
author: Roach, PJ
author: Glushka, John
author: Contreras, Christopher J
author: Ishihara, Mayumi
author: Heiss, Christian
author: Tagliabracci, Vincent S
author: Hurley, TD
author: Karthik, Chandra
author: Azadi, Parastoo
author: DePaoli-Roach, Anna A
db: Pubmed
title: Phosphate incorporation during glycogen synthesis and Lafora disease
source: Cell Metab. 13:274-82
year: 2011

UnificationXref3106
type: UnificationXref
id: REACT_220972
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220972.2

UnificationXref3105
type: UnificationXref
id: 6279964
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279964

UnificationXref3104
type: UnificationXref
id: REACT_226604
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226604.2

CDK-mediated phosphorylation and removal of Cdc6
type: Pathway
data source: Provenance1
pathway component: Phosphorylated Cdc6 is exported from the nucleus
pathway component: Cdc6 protein is phosphorylated by CDK
pathway component: Ubiquitinated Cdc6 is degraded by the proteasome
evidence: Evidence96
xref: UnificationXref1816
xref: UnificationXref1815
pathway order: PathwayStep90
pathway order: PathwayStep91
pathway order: PathwayStep92
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3103
type: UnificationXref
id: 6279963
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279963

UnificationXref3102
type: UnificationXref
id: REACT_206946
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206946.2

UnificationXref3101
type: UnificationXref
id: 6272422
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272422

UnificationXref3100
type: UnificationXref
id: 6272420
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272420

UnificationXref3120
type: UnificationXref
id: REACT_4155
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4155.2

UnificationXref3121
type: UnificationXref
id: CHEBI:18050
db: ChEBI

http://identifiers.org/pubmed/1939222
type: PublicationXref
id: 1939222
author: Cox, TM
author: Gardner, LC
author: Smith, SJ
db: Pubmed
title: Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
source: J Biol Chem 266:22010-8
year: 1991

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

UnificationXref3119
type: UnificationXref
id: 74113
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113

UniProt:Q2QLW3
type: ProteinReference
xref: UnificationXref19194
organism: http://identifiers.org/taxonomy/4530

UnificationXref3116
type: UnificationXref
id: REACT_221363
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221363.2

UnificationXref3115
type: UnificationXref
id: 6279738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279738

UnificationXref3118
type: UnificationXref
id: CHEBI:29101
db: ChEBI

UnificationXref3117
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

UnificationXref3112
type: UnificationXref
id: REACT_212994
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212994.2

UnificationXref3111
type: UnificationXref
id: 6263108
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263108

UnificationXref3114
type: UnificationXref
id: REACT_208079
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_208079.2

UnificationXref3113
type: UnificationXref
id: 6263109
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263109

UnificationXref3131
type: UnificationXref
id: A3BAM6
db: UniProt

UnificationXref3132
type: UnificationXref
id: 6266829
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266829

UnificationXref3130
type: UnificationXref
id: 6266828
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266828

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

UnificationXref3125
type: UnificationXref
id: REACT_2473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2473.2

UnificationXref3124
type: UnificationXref
id: 29472
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29472

UnificationXref3123
type: UnificationXref
id: REACT_14409
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14409.2

UnificationXref3122
type: UnificationXref
id: 212615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212615

UnificationXref3129
type: UnificationXref
id: A3AAY8
db: UniProt

UnificationXref3128
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref3127
type: UnificationXref
id: REACT_3923
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3923.2

UnificationXref3126
type: UnificationXref
id: 83910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

UnificationXref3140
type: UnificationXref
id: 6266833
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266833

UnificationXref3141
type: UnificationXref
id: Q9FNZ8
db: UniProt

UnificationXref3142
type: UnificationXref
id: 6266834
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266834

UnificationXref3143
type: UnificationXref
id: Q67VL0
db: UniProt

UniProt:Q2QM60
type: ProteinReference
xref: UnificationXref18310
organism: http://identifiers.org/taxonomy/4530

UnificationXref3134
type: UnificationXref
id: 6266830
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266830

UnificationXref3133
type: UnificationXref
id: B9EU85
db: UniProt

UnificationXref3136
type: UnificationXref
id: 6266831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266831

UnificationXref3135
type: UnificationXref
id: Q5QMB0
db: UniProt

Degradation of the extracellular matrix
type: Pathway
data source: Provenance1
pathway component: REACT 212480.2
evidence: Evidence1445
xref: RelationshipXref1370
xref: UnificationXref15770
xref: UnificationXref15771
pathway order: PathwayStep1429
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3138
type: UnificationXref
id: 6266832
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266832

UnificationXref3137
type: UnificationXref
id: Q67WP1
db: UniProt

UnificationXref3139
type: UnificationXref
id: Q5QMA9
db: UniProt

UnificationXref10721
type: UnificationXref
id: 6275764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275764

UnificationXref10720
type: UnificationXref
id: Q6KA01
db: UniProt

UnificationXref10723
type: UnificationXref
id: 6275767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275767

UniProt:Q2QM52
type: ProteinReference
xref: UnificationXref18514
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/9792106
type: PublicationXref
id: 9792106
author: Hazlett, TL
author: Sanchez, SA
author: Jameson, DM
author: Brunet, JE
db: Pubmed
title: Aggregation states of mitochondrial malate dehydrogenase
source: Protein Sci 7:2184-2189
year: 1998

UnificationXref10722
type: UnificationXref
id: Q10L79
db: UniProt

UniProt:Q2QM55
type: ProteinReference
xref: UnificationXref12111
organism: http://identifiers.org/taxonomy/4530

UnificationXref10729
type: UnificationXref
id: REACT_215070
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215070.2

UnificationXref10728
type: UnificationXref
id: 6275988
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275988

UnificationXref10725
type: UnificationXref
id: 6275769
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275769

UnificationXref10724
type: UnificationXref
id: Q84PC0
db: UniProt

UnificationXref10727
type: UnificationXref
id: 6275771
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275771

UnificationXref10726
type: UnificationXref
id: 6275770
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275770

UnificationXref10734
type: UnificationXref
id: REACT_260968
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260968.1

UnificationXref10733
type: UnificationXref
id: 6276064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276064

UnificationXref10732
type: UnificationXref
id: 6276062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276062

UnificationXref10731
type: UnificationXref
id: 6275957
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275957

UnificationXref10730
type: UnificationXref
id: Q84Q50
db: UniProt

UnificationXref10739
type: UnificationXref
id: 6275964
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275964

UnificationXref10738
type: UnificationXref
id: REACT_225323
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_225323.2

UnificationXref10737
type: UnificationXref
id: 6275773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275773

UnificationXref10736
type: UnificationXref
id: REACT_12881
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12881.1

UnificationXref10735
type: UnificationXref
id: 202247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=202247

UniProt:Q6K3F7
type: ProteinReference
xref: UnificationXref18526
organism: http://identifiers.org/taxonomy/4530

UnificationXref10701
type: UnificationXref
id: REACT_122466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122466.1

UnificationXref10700
type: UnificationXref
id: 392417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392417

UnificationXref10703
type: UnificationXref
id: 6275742
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275742

UnificationXref10702
type: UnificationXref
id: B9F755
db: UniProt

UnificationXref10705
type: UnificationXref
id: 6275744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275744

UnificationXref10704
type: UnificationXref
id: Q10NR3
db: UniProt

UnificationXref10707
type: UnificationXref
id: 6275746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275746

UnificationXref10706
type: UnificationXref
id: Q84QA3
db: UniProt

UnificationXref10709
type: UnificationXref
id: 6275748
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275748

UniProt:Q2QM38
type: ProteinReference
xref: UnificationXref9103
organism: http://identifiers.org/taxonomy/4530

UnificationXref10708
type: UnificationXref
id: Q0DTA0
db: UniProt

UnificationXref10712
type: UnificationXref
id: 6275752
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275752

UnificationXref10711
type: UnificationXref
id: B9GBU3
db: UniProt

UnificationXref10710
type: UnificationXref
id: 6275749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275749

Beta oxidation of octanoyl-CoA to hexanoyl-CoA
type: Pathway
data source: Provenance1
pathway component: (S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H
evidence: Evidence777
xref: UnificationXref8948
xref: RelationshipXref616
xref: UnificationXref8949
pathway order: PathwayStep764
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10716
type: UnificationXref
id: Q7XAM7
db: UniProt

UnificationXref10715
type: UnificationXref
id: 6275755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275755

UnificationXref10714
type: UnificationXref
id: 6275754
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275754

UnificationXref10713
type: UnificationXref
id: Q2QXW3
db: UniProt

UnificationXref10719
type: UnificationXref
id: 6275761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275761

UnificationXref10718
type: UnificationXref
id: OS11T0145000-01
db: Ensembl

UnificationXref10717
type: UnificationXref
id: 6275758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275758

carbamoyl phosphate + ornithine => citrulline + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1286
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.3.3
xref: UnificationXref13868
xref: UnificationXref13869
left: SmallMolecule1076
left: SmallMolecule1022
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: SmallMolecule1078

ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1287
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.5
xref: UnificationXref13878
xref: UnificationXref13879
left: SmallMolecule5
left: SmallMolecule1079
left: SmallMolecule170
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1080
right: SmallMolecule340
right: SmallMolecule7

kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1283
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.7
xref: UnificationXref13847
xref: UnificationXref13846
left: SmallMolecule333
left: SmallMolecule332
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule334
right: SmallMolecule113

2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1285
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.16
xref: UnificationXref13860
xref: UnificationXref13859
participant stoichiometry: Stoichiometry1471
participant stoichiometry: Stoichiometry1472
left: SmallMolecule1027
left: SmallMolecule1050
left: Adenosine 5'-triphosphate
display name: 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Adenosine 5'-diphosphate
right: SmallMolecule1076

beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1291
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.2.1
xref: UnificationXref13903
xref: UnificationXref13902
left: SmallMolecule1082
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule123
right: SmallMolecule1083

argininosuccinate <=> fumarate + arginine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1288
conversion direction: LEFT_TO_RIGHT
EC number: 4.3.2.1
xref: UnificationXref13883
xref: UnificationXref13884
left: SmallMolecule1080
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule900
right: SmallMolecule131

ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1289
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13892
xref: UnificationXref13893
left: SmallMolecule1081
left: SmallMolecule1078
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1079
right: SmallMolecule1022

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

UnificationXref3189
type: UnificationXref
id: Q6K4N7
db: UniProt

UnificationXref3188
type: UnificationXref
id: 6272334
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272334

UnificationXref3195
type: UnificationXref
id: 6272338
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272338

UnificationXref3196
type: UnificationXref
id: 6272340
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272340

UnificationXref3197
type: UnificationXref
id: REACT_234192
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234192.1

UnificationXref3198
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

UnificationXref3191
type: UnificationXref
id: OS05T0364700-00
db: Ensembl

UnificationXref3192
type: UnificationXref
id: 6272336
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272336

UnificationXref3193
type: UnificationXref
id: Q67WJ7
db: UniProt

UnificationXref10768
type: UnificationXref
id: 6275975
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275975

UnificationXref3194
type: UnificationXref
id: 6272337
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272337

UnificationXref10769
type: UnificationXref
id: 6275976
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275976

UnificationXref10766
type: UnificationXref
id: 6275973
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275973

UnificationXref10767
type: UnificationXref
id: 6275974
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275974

UnificationXref10764
type: UnificationXref
id: 6275971
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275971

UnificationXref3190
type: UnificationXref
id: 6272335
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272335

UnificationXref10765
type: UnificationXref
id: 6275972
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275972

L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1281
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.1.12
xref: UnificationXref13838
xref: UnificationXref13837
left: DPN
left: Water
left: SmallMolecule1023
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: NADH
right: L-Glutaminic acid

UnificationXref10762
type: UnificationXref
id: 6275969
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275969

proline => L-1-pyrroline-5-carboxylate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1280
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.99.8
xref: UnificationXref13829
xref: UnificationXref13830
left: SmallMolecule1025
left: SmallMolecule860
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1024
right: SmallMolecule1075

UnificationXref10763
type: UnificationXref
id: 6275970
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275970

fumarylacetoacetate => fumarate + acetoacetate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1278
conversion direction: LEFT_TO_RIGHT
EC number: 3.7.1.2
xref: UnificationXref13817
xref: UnificationXref13816
left: SmallMolecule1073
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule900
right: SmallMolecule1074

UnificationXref10760
type: UnificationXref
id: 6275791
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275791

UnificationXref10761
type: UnificationXref
id: 6275968
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275968

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1269
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.52
xref: UnificationXref13698
xref: UnificationXref13697
left: SmallMolecule1065
left: DPN
left: SmallMolecule433
display name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: SmallMolecule1066
right: SmallMolecule666

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1270
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.99.7
xref: UnificationXref13714
xref: UnificationXref13715
left: SmallMolecule554
left: SmallMolecule1066
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1067
right: SmallMolecule556
right: SmallMolecule666

http://identifiers.org/pubmed/17785525
type: PublicationXref
id: 17785525
author: Boyault, Cyril
author: Garrido, Carmen
author: Gilquin, Benoit
author: Kwon, So Hee
author: Caron, Cécile
author: Fritah, Sabrina
author: Khochbin, Saadi
author: Vourc'h, Claire
author: Yao, Tso-Pang
author: Matthias, Patrick
author: Zhang, Yu
db: Pubmed
title: HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
source: Genes Dev. 21:2172-81
year: 2007

phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1272
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.58
xref: UnificationXref13721
xref: UnificationXref13722
left: SmallMolecule332
left: SmallMolecule172
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1068
right: SmallMolecule113

UnificationXref10770
type: UnificationXref
id: 6275977
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275977

tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1273
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.5
xref: UnificationXref13756
xref: UnificationXref13757
left: SmallMolecule235
left: SmallMolecule174
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule1069

p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1274
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.5
xref: UnificationXref13758
xref: UnificationXref13759
left: L-Glutaminic acid
left: SmallMolecule1069
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule235
right: SmallMolecule174

p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1275
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.27
xref: UnificationXref13773
xref: UnificationXref13774
left: SmallMolecule293
left: SmallMolecule1069
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1070

homogentisate + O2 => maleylacetoacetate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1276
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.5
xref: UnificationXref13781
xref: UnificationXref13782
left: SmallMolecule293
left: SmallMolecule1070
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1072

maleylacetoacetate => fumarylacetoacetate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1277
conversion direction: LEFT_TO_RIGHT
EC number: 5.2.1.2
xref: UnificationXref13808
xref: UnificationXref13809
left: SmallMolecule1072
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1073

UnificationXref3199
type: UnificationXref
id: 916850
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=916850

UnificationXref10779
type: UnificationXref
id: 1806224
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806224

UnificationXref10775
type: UnificationXref
id: REACT_123499
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123499.1

UnificationXref10776
type: UnificationXref
id: 6275804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275804

UnificationXref10777
type: UnificationXref
id: 6275806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275806

UnificationXref10778
type: UnificationXref
id: REACT_201974
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201974.2

UnificationXref10771
type: UnificationXref
id: 6275979
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275979

UnificationXref10772
type: UnificationXref
id: REACT_253422
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253422.1

alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1268
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.31
xref: UnificationXref13689
xref: UnificationXref13690
left: SmallMolecule1063
left: DPN
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule1064
right: NADH

UnificationXref10773
type: UnificationXref
id: CHEBI:16500
db: ChEBI

UniProt:Q2QM00
type: ProteinReference
xref: UnificationXref3094
organism: http://identifiers.org/taxonomy/4530

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1267
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.1.9
xref: UnificationXref13676
xref: UnificationXref13677
left: SmallMolecule1062
left: DPN
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule1063
right: NADH
right: L-Glutaminic acid

UnificationXref10774
type: UnificationXref
id: 1806240
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240

histidine => urocanate + NH4+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1263
conversion direction: LEFT_TO_RIGHT
EC number: 4.3.1.3
xref: UnificationXref13624
xref: UnificationXref13623
left: SmallMolecule136
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NH4+
right: SmallMolecule1059

Histidine is decarboxylated to histamine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1264
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.22
xref: RelationshipXref1162
xref: UnificationXref13650
xref: UnificationXref13651
left: SmallMolecule136
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1060

methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1260
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.31
xref: UnificationXref13589
xref: UnificationXref13590
left: H+
left: SmallMolecule969
left: NADH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: DPN
right: SmallMolecule1058

methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1261
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.27
xref: UnificationXref13593
xref: UnificationXref13594
left: SmallMolecule969
left: DPN
left: SmallMolecule433
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule1056
right: NADH
right: SmallMolecule666

beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1258
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.2.4
xref: UnificationXref13583
xref: UnificationXref13582
left: Water
left: SmallMolecule1057
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule433
right: SmallMolecule1058

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1259
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.31
xref: UnificationXref13588
xref: UnificationXref13587
left: DPN
left: SmallMolecule1058
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule969
right: NADH

alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1256
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref13549
xref: UnificationXref13548
left: H+
left: SmallMolecule1055
left: NADH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1054
right: DPN

alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1257
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.9
xref: UnificationXref13553
xref: UnificationXref13554
left: SmallMolecule1055
left: SmallMolecule433
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1056
right: SmallMolecule551

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1266
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.1.8
xref: UnificationXref13672
xref: UnificationXref13671
left: H+
left: Oxoglutaric acid
left: SmallMolecule1061
left: SmallMolecule857
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1062
right: Water
right: SmallMolecule859

UnificationXref10748
type: UnificationXref
id: 6275780
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275780

UnificationXref10749
type: UnificationXref
id: 6275781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275781

UnificationXref10746
type: UnificationXref
id: 6275777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275777

UnificationXref10747
type: UnificationXref
id: Q6EX42
db: UniProt

UniProt:Q6K2Y8
type: ProteinReference
xref: UnificationXref13748
organism: http://identifiers.org/taxonomy/4530

alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1255
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref13547
xref: UnificationXref13546
left: SmallMolecule1054
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule1055
right: NADH

UnificationXref10740
type: UnificationXref
id: 6275966
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275966

UnificationXref10741
type: UnificationXref
id: REACT_261850
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261850.1

UniProt:Q2QLN2
type: ProteinReference
xref: UnificationXref8721
organism: http://identifiers.org/taxonomy/4530

UnificationXref10744
type: UnificationXref
id: Q8LN60
db: UniProt

UnificationXref10745
type: UnificationXref
id: 6275776
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275776

UnificationXref10742
type: UnificationXref
id: 1806276
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806276

UnificationXref10743
type: UnificationXref
id: REACT_121667
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121667.1

a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1249
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13493
xref: UnificationXref13492
left: SmallMolecule1041
left: DPN
left: SmallMolecule433
display name: Oxidative decarboxylation of branched-chain alpha-keto acids
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1045
right: NADH
right: SmallMolecule666

isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1250
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.99.10
xref: UnificationXref13501
xref: UnificationXref13500
left: SmallMolecule554
left: SmallMolecule1046
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule556
right: SmallMolecule1049

beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1251
conversion direction: LEFT_TO_RIGHT
EC number: 6.4.1.4
xref: UnificationXref13508
xref: UnificationXref13507
left: SmallMolecule1050
left: SmallMolecule1049
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Adenosine 5'-diphosphate
right: SmallMolecule1051

beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1252
conversion direction: LEFT_TO_RIGHT
EC number: 6.4.1.4
xref: UnificationXref13510
xref: UnificationXref13509
left: Phosphate
left: Adenosine 5'-diphosphate
left: SmallMolecule1051
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1050
right: SmallMolecule1049
right: Adenosine 5'-triphosphate

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1245
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.42
xref: UnificationXref13435
xref: UnificationXref13436
left: SmallMolecule235
left: SmallMolecule1032
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule1033

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1246
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.42
xref: UnificationXref13437
xref: UnificationXref13438
left: L-Glutaminic acid
left: SmallMolecule1033
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule235
right: SmallMolecule1032

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1247
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.42
xref: UnificationXref13465
xref: UnificationXref13466
left: SmallMolecule1037
left: Oxoglutaric acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1041
right: L-Glutaminic acid

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1248
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.42
xref: UnificationXref13467
xref: UnificationXref13468
left: SmallMolecule1041
left: L-Glutaminic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1037
right: Oxoglutaric acid

beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1253
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.18
xref: UnificationXref13522
xref: UnificationXref13521
left: SmallMolecule1051
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1052

alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1254
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.99.3
xref: UnificationXref13532
xref: UnificationXref13533
left: SmallMolecule554
left: SmallMolecule1047
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1053
right: SmallMolecule556

UnificationXref10757
type: UnificationXref
id: 6275788
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275788

UnificationXref10758
type: UnificationXref
id: B9FYI3
db: UniProt

UnificationXref10759
type: UnificationXref
id: 6275790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275790

UniProt:Q2QLM4
type: ProteinReference
xref: UnificationXref11623
organism: http://identifiers.org/taxonomy/4530

UnificationXref10750
type: UnificationXref
id: 6275782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275782

UnificationXref10751
type: UnificationXref
id: 6276019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276019

UnificationXref10752
type: UnificationXref
id: 6276021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276021

UnificationXref10753
type: UnificationXref
id: REACT_221535
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221535.2

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

UnificationXref10754
type: UnificationXref
id: 426658
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426658

UnificationXref10755
type: UnificationXref
id: REACT_125178
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125178.1

UnificationXref10756
type: UnificationXref
id: Q0J3S3
db: UniProt

UnificationXref3148
type: UnificationXref
id: 6266837
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266837

UnificationXref3149
type: UnificationXref
id: 6266838
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266838

UnificationXref3144
type: UnificationXref
id: 6266835
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266835

UnificationXref3145
type: UnificationXref
id: Q6Z336
db: UniProt

UnificationXref3146
type: UnificationXref
id: 6266836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266836

UnificationXref3147
type: UnificationXref
id: Q6YUT5
db: UniProt

4 aminobutyrate aminotransferase homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry651
component: Protein1580
xref: UnificationXref3220
cellular location: GO_0005759
comment: Reactome DB_ID: 6272533

aldehyde dehydrogenase, mitochondrial, tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry652
component: Protein1588
xref: UnificationXref3257
cellular location: GO_0005759
comment: Reactome DB_ID: 6256860

Nek2A:MCC:APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry647
component stoichiometry: Stoichiometry646
component: PhysicalEntity11
component: MCC:APC/C complex (name copied from entity in Homo sapiens)
xref: UnificationXref3109
cellular location: GO_0005829
comment: Reactome DB_ID: 6263105

SPO11:double stand break (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry644
component stoichiometry: Stoichiometry643
component: SPO11 Dimer (name copied from entity in Homo sapiens)
component: PhysicalEntity63
xref: UnificationXref3100
cellular location: GO_0005654
comment: Reactome DB_ID: 6272420

SPO11 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry642
component: Protein1548
xref: UnificationXref3097
cellular location: GO_0005654
comment: Reactome DB_ID: 6272419

Extended And Processed Telomere End (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry641
component stoichiometry: Stoichiometry640
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: PhysicalEntity61
xref: UnificationXref3079
cellular location: GO_0005654
comment: Reactome DB_ID: 6263084

Processive complex loaded on telomere:ligated C-strand Okazaki fragments (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry639
component stoichiometry: Stoichiometry638
component stoichiometry: Stoichiometry637
component stoichiometry: Stoichiometry636
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: PhysicalEntity61
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref3074
cellular location: GO_0005654
comment: Reactome DB_ID: 6262910

Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry633
component stoichiometry: Stoichiometry632
component stoichiometry: Stoichiometry635
component stoichiometry: Stoichiometry634
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: PhysicalEntity60
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref3067
cellular location: GO_0005654
comment: Reactome DB_ID: 6262904

Processive complex loaded on telomere:Okazaki fragments:Remaining Flap (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry631
component stoichiometry: Stoichiometry630
component stoichiometry: Stoichiometry627
component stoichiometry: Stoichiometry628
component stoichiometry: Stoichiometry629
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: PhysicalEntity36
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
component: PhysicalEntity59
xref: UnificationXref3064
cellular location: GO_0005654
comment: Reactome DB_ID: 6262900

Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:dna2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry625
component stoichiometry: Stoichiometry626
component: Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer (name copied from entity in Homo sapiens)
component: Protein937
xref: UnificationXref3061
cellular location: GO_0005654
comment: Reactome DB_ID: 6262899

UnificationXref3152
type: UnificationXref
id: 6279824
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279824

UnificationXref3151
type: UnificationXref
id: REACT_202453
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202453.2

UnificationXref3154
type: UnificationXref
id: CHEBI:16865
db: ChEBI

UnificationXref3153
type: UnificationXref
id: REACT_226844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226844.2

UnificationXref3150
type: UnificationXref
id: 6266840
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266840

Multiubiquitinated Nek2A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry649
component stoichiometry: Stoichiometry648
component: Nek2A:MCC:APC/C complex (name copied from entity in Homo sapiens)
component: PhysicalEntity24
xref: UnificationXref3110
cellular location: GO_0005829
comment: Reactome DB_ID: 6263106

UnificationXref3159
type: UnificationXref
id: REACT_20338
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20338.2

UnificationXref3157
type: UnificationXref
id: GO:0061201
db: GENE ONTOLOGY

UnificationXref3158
type: UnificationXref
id: 428571
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428571

UnificationXref3155
type: UnificationXref
id: 352011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352011

UnificationXref3156
type: UnificationXref
id: REACT_14047
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14047.1

Cysteine is degraded to serine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1329
conversion direction: LEFT_TO_RIGHT
EC number: 4.4.1.1
xref: UnificationXref14356
xref: UnificationXref14357
left: Water
left: SmallMolecule176
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1122
right: SmallMolecule116

Homocysteine is degraded to oxobutanoate and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1328
conversion direction: LEFT_TO_RIGHT
EC number: 4.4.1.2
xref: UnificationXref14355
xref: UnificationXref14354
left: Water
left: SmallMolecule1119
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1121
right: SmallMolecule1122
right: SmallMolecule933

Excess cysteine yields lanthionine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1331
conversion direction: LEFT_TO_RIGHT
EC number: 4.4.1.1
xref: UnificationXref14367
xref: UnificationXref14368
participant stoichiometry: Stoichiometry1506
left: SmallMolecule176
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1122
right: SmallMolecule1124

Excess homocysteine yields homolanthionine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1330
conversion direction: LEFT_TO_RIGHT
EC number: 4.4
xref: UnificationXref14361
xref: UnificationXref14362
participant stoichiometry: Stoichiometry1505
left: SmallMolecule1119
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1122
right: SmallMolecule1123

Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry623
component stoichiometry: Stoichiometry624
component: RPA heterotrimer (name copied from entity in Homo sapiens)
component: Processive complex loaded on telomere:Okazaki fragment:Flap (name copied from entity in Homo sapiens)
xref: UnificationXref3060
cellular location: GO_0005654
comment: Reactome DB_ID: 6262898

RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry605
component stoichiometry: Stoichiometry606
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end (name copied from entity in Homo sapiens)
xref: UnificationXref3041
cellular location: GO_0005654
comment: Reactome DB_ID: 6262896

RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry601
component stoichiometry: Stoichiometry602
component stoichiometry: Stoichiometry603
component stoichiometry: Stoichiometry604
component: PhysicalEntity31
component: PhysicalEntity30
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: RFC Heteropentamer (name copied from entity in Homo sapiens)
xref: UnificationXref3038
cellular location: GO_0005654
comment: Reactome DB_ID: 6262895

glycolate + O2 => glyoxylate + H2O2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1320
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14273
xref: UnificationXref14274
left: SmallMolecule566
left: SmallMolecule1116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1111
right: SmallMolecule568

Processive complex loaded on telomere (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry611
component stoichiometry: Stoichiometry612
component: RNA primer-DNA primer:G-strand extended telomere:PCNA (name copied from entity in Homo sapiens)
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref3047
cellular location: GO_0005654
comment: Reactome DB_ID: 6262902

Conversion of glyoxylate to oxalate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1321
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.3.5
xref: UnificationXref14279
xref: UnificationXref14278
left: SmallMolecule1111
left: SmallMolecule566
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule568
right: SmallMolecule1118

RNA primer-DNA primer:G-strand extended telomere:PCNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry610
component stoichiometry: Stoichiometry609
component stoichiometry: Stoichiometry607
component stoichiometry: Stoichiometry608
component: PhysicalEntity31
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: PhysicalEntity30
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
xref: UnificationXref3044
cellular location: GO_0005654
comment: Reactome DB_ID: 6262901

SAM is sythesized from methionine's reaction with ATP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1323
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.6
xref: UnificationXref14306
xref: UnificationXref14305
left: Water
left: SmallMolecule5
left: SmallMolecule115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule340
right: SmallMolecule464

DNA polymerase epsilon:G-strand extended telomere end (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry594
component: Complex99
xref: UnificationXref3025
cellular location: GO_0005654
comment: Reactome DB_ID: 6262886

S-adenoylhomocysteine is hydrolyzed
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1324
conversion direction: LEFT_TO_RIGHT
EC number: 3.3.1.1
xref: UnificationXref14321
xref: UnificationXref14322
left: Water
left: SmallMolecule1109
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule905
right: SmallMolecule1119

DNA polymerase alpha:primase:DNA polymerase alpha:G-strand extended telomere end (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry595
component stoichiometry: Stoichiometry593
component: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
component: DNA polymerase epsilon:G-strand extended telomere end (name copied from entity in Homo sapiens)
xref: UnificationXref3026
cellular location: GO_0005654
comment: Reactome DB_ID: 6262887

Tryptophan catabolism
type: Pathway
data source: Provenance1
pathway component: kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
pathway component: BiochemicalReaction289
evidence: Evidence1284
xref: UnificationXref13849
xref: RelationshipXref1192
xref: UnificationXref13848
pathway order: PathwayStep1269
pathway order: PathwayStep471
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Cystathionine is formed from homocysteine and serine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1325
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.22
xref: UnificationXref14333
xref: UnificationXref14332
left: SmallMolecule1119
left: SmallMolecule116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1120
right: Water

RNA primer-DNA primer:G-strand extended telomere (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry600
component stoichiometry: Stoichiometry599
component: PhysicalEntity31
component: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)
xref: UnificationXref3033
cellular location: GO_0005654
comment: Reactome DB_ID: 6262890

Cleavage of cystathionine into cysteine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1326
conversion direction: LEFT_TO_RIGHT
EC number: 4.4.1.1
xref: UnificationXref14347
xref: UnificationXref14348
left: SmallMolecule1120
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1121
right: SmallMolecule176
right: SmallMolecule933

RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry598
component stoichiometry: Stoichiometry597
component stoichiometry: Stoichiometry596
component: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
component: PhysicalEntity30
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
xref: UnificationXref3030
cellular location: GO_0005654
comment: Reactome DB_ID: 6262888

UnificationXref3165
type: UnificationXref
id: B9FFJ2
db: UniProt

UnificationXref3164
type: UnificationXref
id: 6272322
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272322

UnificationXref3163
type: UnificationXref
id: Q6YU97
db: UniProt

UnificationXref3162
type: UnificationXref
id: 6272321
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272321

UnificationXref3161
type: UnificationXref
id: Q7XUV8
db: UniProt

Processive complex loaded on telomere:Okazaki fragment:Flap (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry620
component stoichiometry: Stoichiometry621
component stoichiometry: Stoichiometry622
component stoichiometry: Stoichiometry618
component stoichiometry: Stoichiometry619
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: PhysicalEntity35
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
component: PhysicalEntity59
xref: UnificationXref3057
cellular location: GO_0005654
comment: Reactome DB_ID: 6262893

UnificationXref3160
type: UnificationXref
id: GO:0061202
db: GENE ONTOLOGY

Processive complex loaded on telomere:Okazaki fragment complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry616
component stoichiometry: Stoichiometry617
component stoichiometry: Stoichiometry614
component stoichiometry: Stoichiometry615
component stoichiometry: Stoichiometry613
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: PhysicalEntity30
component: G-strand Chromosome end with two additional single strand repeats - Telomeric
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
component: PhysicalEntity59
xref: UnificationXref3054
cellular location: GO_0005654
comment: Reactome DB_ID: 6262892

UnificationXref3166
type: UnificationXref
id: 6272323
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272323

UnificationXref3167
type: UnificationXref
id: Q8LQU5
db: UniProt

UnificationXref3168
type: UnificationXref
id: 6272324
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272324

UnificationXref3169
type: UnificationXref
id: A2ZV22
db: UniProt

glyoxylate + NADPH + H+ => glycolate + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1319
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.79
xref: UnificationXref14259
xref: UnificationXref14258
left: SmallMolecule575
left: SmallMolecule586
left: SmallMolecule1111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule587
right: SmallMolecule1116

glyoxylate + alanine => glycine + pyruvate [mitochondrial matrix]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1318
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.44
xref: UnificationXref14252
xref: UnificationXref14251
left: SmallMolecule963
left: SmallMolecule1114
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule873
right: SmallMolecule1115

UnificationXref10780
type: UnificationXref
id: REACT_122144
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122144.1

glyoxylate + alanine => glycine + pyruvate [peroxisome]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1317
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.44
xref: UnificationXref14245
xref: UnificationXref14246
left: SmallMolecule1110
left: SmallMolecule1111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1113
right: SmallMolecule1112

UnificationXref10781
type: UnificationXref
id: 6276016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276016

Methylation of N-acetyl-5-HT to form melatonin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1314
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14228
xref: UnificationXref14227
left: SmallMolecule1107
left: SmallMolecule464
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule1109
right: SmallMolecule1108

Decarboxylation of 5-hydroxytryptophan forms serotonin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1313
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.28
xref: UnificationXref14128
xref: UnificationXref14129
left: SmallMolecule1105
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1106

Transamination of MOB to methionine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1308
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1
xref: RelationshipXref1231
xref: UnificationXref14095
xref: UnificationXref14094
left: PhysicalEntity152
left: SmallMolecule1102
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity153
right: SmallMolecule115

UnificationXref10785
type: UnificationXref
id: 6275783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275783

Dopa is decarboxylated to dopamine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1311
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.28
xref: UnificationXref14119
xref: UnificationXref14118
left: SmallMolecule1103
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1104

UnificationXref10784
type: UnificationXref
id: REACT_233818
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233818.1

Acireductone is created
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1306
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.77
xref: UnificationXref14073
xref: UnificationXref14074
participant stoichiometry: Stoichiometry1479
left: SmallMolecule1100
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule3
right: SmallMolecule1101

UnificationXref10783
type: UnificationXref
id: 6276067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276067

Acireductone is oxidized to MOB
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1307
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.54
xref: UnificationXref14089
xref: UnificationXref14088
left: SmallMolecule293
left: SmallMolecule1101
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule460
right: SmallMolecule1102

UnificationXref10782
type: UnificationXref
id: REACT_224429
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224429.2

UnificationXref10789
type: UnificationXref
id: REACT_215617
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215617.2

Methylthio-ribulose-P = Methylthio-ribose-P
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1305
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.23
xref: UnificationXref14057
xref: UnificationXref14058
left: SmallMolecule1099
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1098

UnificationXref10788
type: UnificationXref
id: 6280035
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280035

UnificationXref10787
type: UnificationXref
id: REACT_251625
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251625.1

UnificationXref10786
type: UnificationXref
id: 6275785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275785

UnificationXref3170
type: UnificationXref
id: 6272325
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272325

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

UnificationXref3172
type: UnificationXref
id: 6272326
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272326

UnificationXref3171
type: UnificationXref
id: Q6YU96
db: UniProt

UnificationXref3174
type: UnificationXref
id: 6272327
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272327

UnificationXref3173
type: UnificationXref
id: Q5ZAF5
db: UniProt

UnificationXref3176
type: UnificationXref
id: 6272328
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272328

UnificationXref3175
type: UnificationXref
id: Q53MQ4
db: UniProt

UnificationXref3179
type: UnificationXref
id: A3AC49
db: UniProt

UnificationXref3177
type: UnificationXref
id: A3AUI4
db: UniProt

UnificationXref3178
type: UnificationXref
id: 6272329
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272329

http://identifiers.org/pubmed/9461497
type: PublicationXref
id: 9461497
author: Zhang, H
author: Tai, HH
author: Ensor, CM
db: Pubmed
title: Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
source: Biochem J 330:103-8
year: 1998

Methylthio-ribose-P = Methylthio-ribulose-P
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1304
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.23
xref: UnificationXref14056
xref: UnificationXref14055
left: SmallMolecule1098
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1099

Spermine is oxidized to spermidine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1302
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14043
xref: UnificationXref14044
left: SmallMolecule566
left: SmallMolecule570
left: SmallMolecule1096
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1097
right: SmallMolecule568
right: SmallMolecule1095

Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1299
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.16
xref: UnificationXref14000
xref: UnificationXref14001
left: SmallMolecule1088
left: SmallMolecule1087
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1090
right: SmallMolecule1089

S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1298
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.50
xref: UnificationXref13985
xref: UnificationXref13986
left: SmallMolecule464
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1088

UnificationXref10790
type: UnificationXref
id: 1806200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806200

N-acetylspermine is oxidised to spermidine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1301
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14021
xref: UnificationXref14020
left: SmallMolecule566
left: SmallMolecule570
left: SmallMolecule1094
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule568
right: SmallMolecule1093
right: SmallMolecule1095

UnificationXref10791
type: UnificationXref
id: REACT_124533
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124533.1

N-acetylspermidine is oxidized to putrescine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1300
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14014
xref: UnificationXref14013
left: SmallMolecule1091
left: SmallMolecule566
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1092
right: SmallMolecule568
right: SmallMolecule1093

UnificationXref10792
type: UnificationXref
id: 1806205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806205

gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1292
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref13929
xref: UnificationXref13930
left: Water
left: SmallMolecule1083
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule1084

UnificationXref10794
type: UnificationXref
id: 6276036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276036

Arginine<=>Agmatine+CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1294
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.19
xref: UnificationXref13946
xref: UnificationXref13945
left: SmallMolecule131
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1085

UnificationXref10793
type: UnificationXref
id: REACT_124477
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124477.1

Agmatine + H2O <=> putrescine + urea
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1295
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.3.11
xref: UnificationXref13957
xref: UnificationXref13956
left: Water
left: SmallMolecule1085
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1087
right: SmallMolecule1086

UnificationXref10796
type: UnificationXref
id: 6276038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276038

ornithine => putrescine + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1297
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.17
xref: UnificationXref13968
xref: UnificationXref13967
left: SmallMolecule1081
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1087

UnificationXref10795
type: UnificationXref
id: 6276037
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276037

UnificationXref10798
type: UnificationXref
id: 6276040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276040

UnificationXref10797
type: UnificationXref
id: 6276039
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276039

UnificationXref10799
type: UnificationXref
id: 6276041
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276041

UnificationXref3183
type: UnificationXref
id: Q6K4N6
db: UniProt

UnificationXref3182
type: UnificationXref
id: 6272331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272331

UnificationXref3181
type: UnificationXref
id: Q2QN95
db: UniProt

UnificationXref3180
type: UnificationXref
id: 6272330
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272330

UniProt:Q2QLI0
type: ProteinReference
xref: UnificationXref839
organism: http://identifiers.org/taxonomy/4530

UnificationXref3187
type: UnificationXref
id: OS04T0201800-00
db: Ensembl

UnificationXref3186
type: UnificationXref
id: 6272333
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272333

UnificationXref3185
type: UnificationXref
id: Q7XUV9
db: UniProt

UnificationXref3184
type: UnificationXref
id: 6272332
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272332

Mad1:kinetochore complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry377
component stoichiometry: Stoichiometry376
component: PhysicalEntity11
component: Protein966
xref: UnificationXref2015
cellular location: GO_0005829
comment: Reactome DB_ID: 6261243

Kinetochore:Mad1:MAD2 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry378
component stoichiometry: Stoichiometry379
component: Mad1:kinetochore complex (name copied from entity in Homo sapiens)
component: Protein962
xref: UnificationXref2016
cellular location: GO_0005829
comment: Reactome DB_ID: 6261252

CCNB:CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry373
component stoichiometry: Stoichiometry372
component: Protein958
component: Protein959
xref: UnificationXref1992
cellular location: GO_0005829
comment: Reactome DB_ID: 6262321

CCNB:p-T14-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry374
component stoichiometry: Stoichiometry375
component: Protein960
component: Protein958
xref: UnificationXref1994
cellular location: GO_0005829
comment: Reactome DB_ID: 6262322

UniProt:Q6K3R8
type: ProteinReference
xref: UnificationXref18983
organism: http://identifiers.org/taxonomy/4530

MCC:APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry386
component stoichiometry: Stoichiometry387
component: Complex68
component: hBUBR1:hBUB3:MAD2*:CDC20 complex (name copied from entity in Homo sapiens)
xref: UnificationXref2053
cellular location: GO_0005829
comment: Reactome DB_ID: 6261379

MAD2*CDC20 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry381
component stoichiometry: Stoichiometry380
component: Protein589
component: Protein962
xref: UnificationXref2027
cellular location: GO_0005829
comment: Reactome DB_ID: 6261381

hBUBR1:hBUB3:MAD2*:CDC20 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry384
component stoichiometry: Stoichiometry385
component stoichiometry: Stoichiometry383
component stoichiometry: Stoichiometry382
component: Protein589
component: Protein969
component: Protein976
component: Protein962
xref: UnificationXref2050
cellular location: GO_0005829
comment: Reactome DB_ID: 6261282

HDAC1:RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry396
component stoichiometry: Stoichiometry397
component: Protein980
component: RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
xref: UnificationXref2143
cellular location: GO_0005654
comment: Reactome DB_ID: 6273945

RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry393
component stoichiometry: Stoichiometry394
component stoichiometry: Stoichiometry395
component: PhysicalEntity40
component: Protein1020
component: PhysicalEntity39
xref: UnificationXref2142
cellular location: GO_0005654
comment: Reactome DB_ID: 6273918

HDAC1:RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry391
component stoichiometry: Stoichiometry392
component: Protein980
component: RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
xref: UnificationXref2123
cellular location: GO_0005654
comment: Reactome DB_ID: 6273947

RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry388
component stoichiometry: Stoichiometry390
component stoichiometry: Stoichiometry389
component: Protein993
component: Protein1008
component: PhysicalEntity39
xref: UnificationXref2122
cellular location: GO_0005654
comment: Reactome DB_ID: 6273932

UniProt:Q6K424
type: ProteinReference
xref: UnificationXref15266
organism: http://identifiers.org/taxonomy/4530

Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry398
component stoichiometry: Stoichiometry399
component: PhysicalEntity42
component: Protein885
xref: UnificationXref2263
cellular location: GO_0005654
comment: Reactome DB_ID: 6274572

RBL1:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry401
component stoichiometry: Stoichiometry400
component: Protein993
component: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
xref: UnificationXref2264
cellular location: GO_0005654
comment: Reactome DB_ID: 6274579

RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry402
component stoichiometry: Stoichiometry403
component: RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
component: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
xref: UnificationXref2267
cellular location: GO_0005654
comment: Reactome DB_ID: 6274577

RBL2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry405
component stoichiometry: Stoichiometry404
component: Protein1020
component: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
xref: UnificationXref2270
cellular location: GO_0005654
comment: Reactome DB_ID: 6274575

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry407
component stoichiometry: Stoichiometry406
component: RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
component: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
xref: UnificationXref2273
cellular location: GO_0005654
comment: Reactome DB_ID: 6274573

PP2A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry411
component stoichiometry: Stoichiometry410
component stoichiometry: Stoichiometry412
component: PhysicalEntity44
component: PhysicalEntity45
component: Protein1119
xref: UnificationXref2308
cellular location: GO_0005654
comment: Reactome DB_ID: 6274567

Sulfite is oxidized to sulfate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1332
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.3.1
xref: UnificationXref14384
xref: UnificationXref14383
left: SmallMolecule360
left: Water
left: SmallMolecule1125
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1126
right: SmallMolecule143

Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1337
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.37
xref: UnificationXref14404
xref: UnificationXref14405
left: SmallMolecule877
left: SmallMolecule1115
display name: ALAS condenses SUCC-CoA and Gly to form dALA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1128
right: SmallMolecule433
right: SmallMolecule666

ALAD octamer associates with Pb++, forming a catalytically inactive complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1338
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14415
xref: UnificationXref14414
participant stoichiometry: Stoichiometry1513
participant stoichiometry: Stoichiometry1512
left: Complex683
left: SmallMolecule1129
display name: ALAD binds to Pb2+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule213
right: Complex684

SCF(Skp2):Cks1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry415
component stoichiometry: Stoichiometry419
component: SCF(Skp2) complex (name copied from entity in Homo sapiens)
component: Protein1128
xref: UnificationXref2381
cellular location: GO_0005654
comment: Reactome DB_ID: 6274617

Two molecules of ALA condense to form porphobilinogen (PBG)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1339
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.24
xref: UnificationXref14422
xref: UnificationXref14421
participant stoichiometry: Stoichiometry1517
participant stoichiometry: Stoichiometry1518
left: SmallMolecule1130
display name: ALAD condenses 2 dALAs to form PBG
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1131
right: Water

p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry420
component stoichiometry: Stoichiometry421
component: SCF(Skp2):Cks1 complex (name copied from entity in Homo sapiens)
component: Protein1125
xref: UnificationXref2382
cellular location: GO_0005654
comment: Reactome DB_ID: 6274618

SCF(Skp2) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry417
component stoichiometry: Stoichiometry416
component stoichiometry: Stoichiometry418
component: PhysicalEntity16
component: Protein1156
component: Protein1129
xref: UnificationXref2380
cellular location: GO_0005654
comment: Reactome DB_ID: 6274616

Cyclin E:Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry424
component stoichiometry: Stoichiometry425
component: Protein1197
component: PhysicalEntity47
xref: UnificationXref2459
cellular location: GO_0005829
comment: Reactome DB_ID: 6255163

Ub-p-T401,S672,1035-RBL2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry423
component stoichiometry: Stoichiometry422
component: Protein1125
component: PhysicalEntity46
xref: UnificationXref2422
cellular location: GO_0005654
comment: Reactome DB_ID: 6274620

Oxidation of protoporphyrinogen IX to protoporphyrin IX
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1344
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.4
xref: UnificationXref14483
xref: UnificationXref14484
participant stoichiometry: Stoichiometry1530
participant stoichiometry: Stoichiometry1531
left: SmallMolecule1140
left: SmallMolecule1139
display name: PPO oxidises PPGEN9 to PRIN9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1141
right: SmallMolecule1143

Ferrous iron is inserted into protoporphyrin IX to form heme
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1345
conversion direction: LEFT_TO_RIGHT
EC number: 4.99.1.1
xref: UnificationXref14495
xref: UnificationXref14496
participant stoichiometry: Stoichiometry1534
left: SmallMolecule1145
left: SmallMolecule363
display name: FECH binds Fe2+ to PRIN9 to form heme
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: protoheme

Four PBGs combine through deamination to form hydroxymethylbilane (HMB)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1340
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.61
xref: UnificationXref14433
xref: UnificationXref14432
participant stoichiometry: Stoichiometry1519
participant stoichiometry: Stoichiometry1520
left: SmallMolecule1131
left: Water
display name: 4 PBGs bind to form HMB
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1132
right: SmallMolecule933

Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1341
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.37
xref: UnificationXref14446
xref: UnificationXref14447
participant stoichiometry: Stoichiometry1523
left: SmallMolecule1134
display name: UROD decarboxylates URO3 to COPRO3
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1135

Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1342
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.37
xref: UnificationXref14455
xref: UnificationXref14454
participant stoichiometry: Stoichiometry1525
left: SmallMolecule1136
display name: UROD decarboxylates URO1 to COPRO1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule1137

Conversion of coproporphyrinogen III to protoporphyrinogen IX
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1343
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.3
xref: UnificationXref14470
xref: UnificationXref14471
participant stoichiometry: Stoichiometry1527
participant stoichiometry: Stoichiometry1528
participant stoichiometry: Stoichiometry1526
left: SmallMolecule1139
left: SmallMolecule1138
display name: CPO transforms COPRO3 to PPGEN9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1140
right: SmallMolecule1141
right: SmallMolecule1142

UniProt:Q6K3T2
type: ProteinReference
xref: UnificationXref3358
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QMG2
type: ProteinReference
xref: UnificationXref7750
organism: http://identifiers.org/taxonomy/4530

RFC Heteropentamer:RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry339
component stoichiometry: Stoichiometry340
component: RFC Heteropentamer (name copied from entity in Homo sapiens)
component: RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
xref: UnificationXref1863
cellular location: GO_0005654
comment: Reactome DB_ID: 6255054

Unwinding complex at replication fork (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry333
component stoichiometry: Stoichiometry332
component stoichiometry: Stoichiometry331
component stoichiometry: Stoichiometry330
component: PhysicalEntity32
component: Protein878
component: GINS complex (name copied from entity in Homo sapiens)
component: Complex87
xref: UnificationXref1842
cellular location: GO_0005654
comment: Reactome DB_ID: 6263101

RFC Heteropentamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry338
component stoichiometry: Stoichiometry337
component stoichiometry: Stoichiometry336
component stoichiometry: Stoichiometry335
component stoichiometry: Stoichiometry334
component: Protein924
component: Protein922
component: Protein923
component: Protein928
component: Protein929
xref: UnificationXref1862
cellular location: GO_0005654
comment: Reactome DB_ID: 6255053

Mcm4,6,7 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry323
component stoichiometry: Stoichiometry325
component stoichiometry: Stoichiometry324
component: Protein867
component: Protein873
component: Protein870
xref: UnificationXref1817
cellular location: GO_0005654
comment: Reactome DB_ID: 6255029

http://identifiers.org/pubmed/11447121
type: PublicationXref
id: 11447121
author: Morimoto, R I
author: Eriksson, J E
author: MacKintosh, C
author: Mikhailov, A
author: Hietakangas, V
author: Kallio, M
author: Sistonen, L
author: Morrice, N
author: Rantanen, J O
author: Hellman, J
author: Meinander, A
author: Holmberg, C I
db: Pubmed
title: Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
source: EMBO J. 20:3800-10
year: 2001

GINS complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry327
component stoichiometry: Stoichiometry326
component stoichiometry: Stoichiometry329
component stoichiometry: Stoichiometry328
component: Protein916
component: Protein917
component: Protein921
component: PhysicalEntity16
xref: UnificationXref1841
cellular location: GO_0005654
comment: Reactome DB_ID: 6263100

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry319
component stoichiometry: Stoichiometry320
component: PhysicalEntity31
component: RNA primer:origin duplex:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)
xref: UnificationXref1795
cellular location: GO_0005654
comment: Reactome DB_ID: 6254656

ubiquitinated Cdc6 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry321
component stoichiometry: Stoichiometry322
component: Protein912
component: PhysicalEntity24
xref: UnificationXref1812
cellular location: GO_0005829
comment: Reactome DB_ID: 6254727

DNA polymerase alpha:primase:DNA polymerase alpha:origin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry315
component stoichiometry: Stoichiometry314
component: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
component: Complex98
xref: UnificationXref1752
cellular location: GO_0005654
comment: Reactome DB_ID: 6254603

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

RNA primer:origin duplex:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry318
component stoichiometry: Stoichiometry317
component stoichiometry: Stoichiometry316
component: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
component: PhysicalEntity30
component: PhysicalEntity28
xref: UnificationXref1778
cellular location: GO_0005654
comment: Reactome DB_ID: 6254605

RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry343
component stoichiometry: Stoichiometry342
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: RFC Heteropentamer:RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
xref: UnificationXref1869
cellular location: GO_0005654
comment: Reactome DB_ID: 6255060

PCNA homotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry341
component: Protein930
xref: UnificationXref1868
cellular location: GO_0005654
comment: Reactome DB_ID: 6255059

http://identifiers.org/pubmed/9199292
type: PublicationXref
id: 9199292
author: Dynlacht, BD
author: Sánchez, I
author: Woo, MS
db: Pubmed
title: p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
source: Mol Cell Biol 17:3566-79
year: 1997

Processive complex:Okazaki fragment:Flap (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry354
component stoichiometry: Stoichiometry355
component: PhysicalEntity35
component: Processive complex:Okazaki fragment complex (name copied from entity in Homo sapiens)
xref: UnificationXref1903
cellular location: GO_0005654
comment: Reactome DB_ID: 6255087

Processive complex:Okazaki fragment:Flap:RPA heterotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry356
component stoichiometry: Stoichiometry360
component: Processive complex:Okazaki fragment:Flap (name copied from entity in Homo sapiens)
component: RPA heterotrimer (name copied from entity in Homo sapiens)
xref: UnificationXref1907
cellular location: GO_0005654
comment: Reactome DB_ID: 6255090

RPA heterotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry357
component stoichiometry: Stoichiometry358
component stoichiometry: Stoichiometry359
component: PhysicalEntity16
component: Protein886
component: Protein887
xref: UnificationXref1906
cellular location: GO_0005654
comment: Reactome DB_ID: 6255089

Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry362
component stoichiometry: Stoichiometry361
component: Processive complex:Okazaki fragment:Flap:RPA heterotrimer (name copied from entity in Homo sapiens)
component: Protein937
xref: UnificationXref1910
cellular location: GO_0005654
comment: Reactome DB_ID: 6255094

RNA primer-DNA primer:origin duplex:PCNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry345
component stoichiometry: Stoichiometry344
component: PCNA homotrimer (name copied from entity in Homo sapiens)
component: RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
xref: UnificationXref1872
cellular location: GO_0005654
comment: Reactome DB_ID: 6255062

DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry349
component stoichiometry: Stoichiometry348
component stoichiometry: Stoichiometry347
component stoichiometry: Stoichiometry346
component: Protein933
component: Protein934
component: Protein931
component: Protein932
xref: UnificationXref1886
cellular location: GO_0005654
comment: Reactome DB_ID: 6255080

Processive complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry351
component stoichiometry: Stoichiometry350
component: RNA primer-DNA primer:origin duplex:PCNA (name copied from entity in Homo sapiens)
component: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref1887
cellular location: GO_0005654
comment: Reactome DB_ID: 6255081

Processive complex:Okazaki fragment complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry352
component stoichiometry: Stoichiometry353
component: Processive complex (name copied from entity in Homo sapiens)
component: PhysicalEntity34
xref: UnificationXref1898
cellular location: GO_0005654
comment: Reactome DB_ID: 6255084

Processive complex:Okazaki fragments:Remaining Flap (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry364
component stoichiometry: Stoichiometry365
component stoichiometry: Stoichiometry363
component: PhysicalEntity36
component: Processive complex (name copied from entity in Homo sapiens)
component: PhysicalEntity34
xref: UnificationXref1915
cellular location: GO_0005654
comment: Reactome DB_ID: 6255096

ubiquitinated phospho-COP1(ser-387) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry369
component stoichiometry: Stoichiometry370
component: Protein953
component: PhysicalEntity24
xref: UnificationXref1975
cellular location: GO_0005829
comment: Reactome DB_ID: 6266876

Processive complex:nicked DNA from adjacent Okazaki fragments (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry366
component stoichiometry: Stoichiometry367
component: PhysicalEntity37
component: Processive complex (name copied from entity in Homo sapiens)
xref: UnificationXref1918
cellular location: GO_0005654
comment: Reactome DB_ID: 6255097

Ac-Cohesin Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry479
component stoichiometry: Stoichiometry478
component stoichiometry: Stoichiometry477
component stoichiometry: Stoichiometry476
component stoichiometry: Stoichiometry480
component: Protein817
component: Protein1317
component: Protein813
component: Protein804
component: Protein796
xref: UnificationXref2653
cellular location: GO_0005654
comment: Reactome DB_ID: 6277832

Ac-Cohesin:PDS5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry475
component stoichiometry: Stoichiometry474
component stoichiometry: Stoichiometry481
component: Ac-Cohesin Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity16
component: PhysicalEntity25
xref: UnificationXref2654
cellular location: GO_0005654
comment: Reactome DB_ID: 6277833

Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry483
component stoichiometry: Stoichiometry482
component: Ac-Cohesin:PDS5:WAPAL (name copied from entity in Homo sapiens)
component: PhysicalEntity21
xref: UnificationXref2655
cellular location: GO_0005654
comment: Reactome DB_ID: 6277834

Cleavage of 5-oxoproline to form glutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1393
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.2.9
xref: UnificationXref15328
xref: UnificationXref15327
participant stoichiometry: Stoichiometry1561
left: Water
left: SmallMolecule5
left: SmallMolecule1192
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule3
right: SmallMolecule6

taurolithocholate + PAPS => taurolithocholate sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1390
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2
xref: UnificationXref15310
xref: UnificationXref15311
left: SmallMolecule1191
left: SmallMolecule264
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule188

lithocholate + PAPS => lithocholate sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1389
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2
xref: UnificationXref15305
xref: UnificationXref15306
left: SmallMolecule1189
left: SmallMolecule264
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1190
right: SmallMolecule1179

dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1388
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.15
xref: UnificationXref15297
xref: UnificationXref15298
left: dehydroepiandrosterone
left: SmallMolecule264
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule1188

CCNA:p-T160-CDK2:E2F1/E2F3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry490
component stoichiometry: Stoichiometry491
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
component: PhysicalEntity29
xref: UnificationXref2684
cellular location: GO_0005654
comment: Reactome DB_ID: 6263146

estrone + PAPS => estrone 3-sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1387
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.4
xref: UnificationXref15292
xref: UnificationXref15293
left: SmallMolecule264
left: SmallMolecule1187
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule245
right: SmallMolecule1179

CCNA:p-T160-CDK2:p-E2F1/p-E2F3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry492
component stoichiometry: Stoichiometry493
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
component: PhysicalEntity55
xref: UnificationXref2712
cellular location: GO_0005654
comment: Reactome DB_ID: 6263195

pregnenolone + PAPS => pregnenolone sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1386
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.15
xref: UnificationXref15287
xref: UnificationXref15288
left: SmallMolecule264
left: Pregnenolone
display name: SULTs transfer (SO4)2- group to PREG
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule1186

Cohesin:PDS5:WAPAL:Centromere (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry484
component stoichiometry: Stoichiometry485
component: Complex71
component: PhysicalEntity27
xref: UnificationXref2676
cellular location: GO_0005654
comment: Reactome DB_ID: 6277875

27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1385
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.2
xref: UnificationXref15282
xref: UnificationXref15283
left: SmallMolecule264
left: SmallMolecule1184
display name: SULTs transfer (SO4)2- group to 27HCHOL
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule1185

Ac-Cohesin:PDS5:WAPAL:Centromere (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry488
component stoichiometry: Stoichiometry487
component: Ac-Cohesin:PDS5:WAPAL (name copied from entity in Homo sapiens)
component: PhysicalEntity27
xref: UnificationXref2677
cellular location: GO_0005654
comment: Reactome DB_ID: 6277876

http://identifiers.org/pubmed/9469823
type: PublicationXref
id: 9469823
author: Watanabe, H
author: Gu, L
author: Hong, Y
author: Li, G M
author: McCulloch, S
db: Pubmed
title: ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
source: Nucleic Acids Res. 26:1173-8
year: 1998

cholesterol + PAPS => cholesterol sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1384
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.2
xref: UnificationXref15274
xref: UnificationXref15275
left: cholesterol
left: SmallMolecule264
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule1183

CCNA:p-T14-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry499
component stoichiometry: Stoichiometry498
component: PhysicalEntity41
component: Protein1357
xref: UnificationXref2724
cellular location: GO_0005654
comment: Reactome DB_ID: 6262443

3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1383
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.1
xref: UnificationXref15190
xref: UnificationXref15189
left: SmallMolecule264
left: SmallMolecule1181
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1179
right: SmallMolecule1182

cytoplasmic Cyclin B1:Cdc2 complexes
type: Complex
data source: Provenance1
member physical entity: Cyclin B1:phospho-Cdc2(Thr 161, Thr 14, Tyr 15) (name copied from entity in Homo sapiens)
member physical entity: Cyclin B1:phospho-Cdc2 ( Thr 14) (name copied from entity in Homo sapiens)
member physical entity: phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) (name copied from entity in Homo sapiens)
xref: UnificationXref2735
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6262308

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1382
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.2.1
xref: UnificationXref15181
xref: UnificationXref15182
left: SmallMolecule1178
left: SmallMolecule264
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1180
right: SmallMolecule1179

CCNA:CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry495
component stoichiometry: Stoichiometry494
component: PhysicalEntity51
component: Protein959
xref: UnificationXref2717
cellular location: GO_0005829
comment: Reactome DB_ID: 6262404

CCNA:p-T14-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry497
component stoichiometry: Stoichiometry496
component: Protein960
component: PhysicalEntity51
xref: UnificationXref2720
cellular location: GO_0005829
comment: Reactome DB_ID: 6262445

Cyclin B1:phospho-Cdc2(Thr 161, Thr 14, Tyr 15) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry502
component stoichiometry: Stoichiometry503
component: Protein427
component: Protein1358
xref: UnificationXref2732
cellular location: GO_0005829
comment: Reactome DB_ID: 6262301

Cyclin B1:phospho-Cdc2 ( Thr 14) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry500
component stoichiometry: Stoichiometry501
component: Protein960
component: Protein427
xref: UnificationXref2729
cellular location: GO_0005829
comment: Reactome DB_ID: 6262298

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

8-oxoguanine [ChEBI:29116]
type: SmallMoleculeReference
name: 8-oxoguanine
xref: UnificationXref15825

UniProt:Q2QME5
type: ProteinReference
xref: UnificationXref18429
organism: http://identifiers.org/taxonomy/4530

ACY:Zn2+ dimers hydrolyse mercapturic acids
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1406
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1.14
xref: UnificationXref15500
xref: UnificationXref15501
left: Water
left: SmallMolecule1235
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1238
right: SmallMolecule1241

GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1405
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.2.2
xref: UnificationXref15472
xref: UnificationXref15473
left: SmallMolecule1229
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule793
right: SmallMolecule1232

phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry504
component stoichiometry: Stoichiometry505
component: Protein428
component: Protein1359
xref: UnificationXref2734
cellular location: GO_0005829
comment: Reactome DB_ID: 6262307

Aflatoxin B1 oxidized to Aflatoxin-8,9-oxide
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1402
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15443
xref: UnificationXref15444
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule1221
display name: CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule1223

nuclear Cyclin B1:Cdc2 complexes
type: Complex
data source: Provenance1
member physical entity: CCNB1:p-T14-CDK1 (name copied from entity in Homo sapiens)
member physical entity: CCNB1:p-T14,Y15,T161-CDK1 (name copied from entity in Homo sapiens)
member physical entity: p-4S-CCNB1:p-T161-CDK1 (name copied from entity in Homo sapiens)
xref: UnificationXref2741
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6262316

CYP3A4,5 hydroxylates AFB1 to AFQ1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1401
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15439
xref: UnificationXref15440
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule1221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule1222

CCNB1:p-T14-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry506
component stoichiometry: Stoichiometry507
component: Protein371
component: Protein1357
xref: UnificationXref2736
cellular location: GO_0005654
comment: Reactome DB_ID: 6262310

MGST trimers transfer GS from GSH to AFXBO and AFNBO
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1404
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.18
xref: UnificationXref15459
xref: UnificationXref15458
left: SmallMolecule1225
left: SmallMolecule422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1226

CCNB1:p-T14,Y15,T161-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry508
component stoichiometry: Stoichiometry509
component: Protein1360
component: Protein371
xref: UnificationXref2738
cellular location: GO_0005654
comment: Reactome DB_ID: 6262312

CYP1A2, 3A4 oxidise AFB1 to AFNBO
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1403
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15449
xref: UnificationXref15448
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule1221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1224
right: Water
right: NADP+

p-4S-CCNB1:p-T161-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry510
component stoichiometry: Stoichiometry511
component: Protein1361
component: Protein372
xref: UnificationXref2740
cellular location: GO_0005654
comment: Reactome DB_ID: 6262315

Glutathione is hydrolyzed
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1395
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.2.2
xref: UnificationXref15369
xref: UnificationXref15368
left: SmallMolecule1202
left: SmallMolecule1194
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1204
right: Complex706

active nuclear Cyclin B1:Cdc2 complexes
type: Complex
data source: Provenance1
member physical entity: Complex44
member physical entity: p-4S-CCNB1:p-T161-CDK1 (name copied from entity in Homo sapiens)
xref: UnificationXref2755
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6262452

gamma-glutamylcysteine combines with glycine to form glutathione
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1394
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.3
xref: UnificationXref15340
xref: UnificationXref15341
left: SmallMolecule5
left: SmallMolecule123
left: SmallMolecule1193
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule422

Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry525
component stoichiometry: Stoichiometry524
component: Protein1279
component: phosphorylated anaphase promoting complex (APC/C) (name copied from entity in Homo sapiens)
xref: UnificationXref2808
cellular location: GO_0005654
comment: Reactome DB_ID: 6262742

GST dimers conjugate GSH with cytosolic substrates
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1398
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.18
xref: UnificationXref15427
xref: UnificationXref15428
left: SmallMolecule1213
left: SmallMolecule422
display name: Glutathione conjugation of cytosolic substrates
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1217

phosphorylated anaphase promoting complex (APC/C) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry518
component stoichiometry: Stoichiometry517
component stoichiometry: Stoichiometry519
component stoichiometry: Stoichiometry514
component stoichiometry: Stoichiometry513
component stoichiometry: Stoichiometry516
component stoichiometry: Stoichiometry515
component stoichiometry: Stoichiometry523
component stoichiometry: Stoichiometry522
component stoichiometry: Stoichiometry521
component stoichiometry: Stoichiometry512
component stoichiometry: Stoichiometry520
component: Protein1402
component: PhysicalEntity16
component: Protein1363
component: Protein1377
component: Protein1367
component: Protein1394
component: Protein1376
component: Protein1397
component: Protein1399
component: Protein1382
component: Protein1398
component: Protein1372
xref: UnificationXref2807
cellular location: GO_0005654
comment: Reactome DB_ID: 6262553

GST trimers transfer GS from GSH to luminal substrates
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1397
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.18
xref: UnificationXref15394
xref: UnificationXref15395
left: SmallMolecule1205
left: SmallMolecule1208
display name: MGST trimers conjugate GSH with luminal substrates
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1209

Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry527
component stoichiometry: Stoichiometry526
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
component: Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
xref: UnificationXref2809
cellular location: GO_0005654
comment: Reactome DB_ID: 6262743

Cyclin E2:phospho-Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry434
component stoichiometry: Stoichiometry435
component: Protein1080
component: Protein1226
xref: UnificationXref2472
cellular location: GO_0005654
comment: Reactome DB_ID: 6255235

Cyclin E2:Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry432
component stoichiometry: Stoichiometry433
component: Protein1080
component: Protein885
xref: UnificationXref2471
cellular location: GO_0005654
comment: Reactome DB_ID: 6255234

Cyclin E1:phospho-Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry430
component stoichiometry: Stoichiometry431
component: Protein1094
component: Protein1226
xref: UnificationXref2467
cellular location: GO_0005654
comment: Reactome DB_ID: 6255228

Cyclin E1:Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry428
component stoichiometry: Stoichiometry429
component: Protein1094
component: Protein885
xref: UnificationXref2465
cellular location: GO_0005654
comment: Reactome DB_ID: 6255227

Cyclin E:Cdk2 complexes (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry427
component stoichiometry: Stoichiometry426
component: PhysicalEntity43
component: Protein885
xref: UnificationXref2462
cellular location: GO_0005654
comment: Reactome DB_ID: 6255194

CYP26A1,B1 4-hydroxylate atRA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1360
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14896
xref: UnificationXref14897
left: SmallMolecule739
left: SmallMolecule1160
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule492
right: SmallMolecule1161

CYP4F12 hydroxylates arachidonic acid
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1357
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14723
xref: UnificationXref14722
left: SmallMolecule812
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1159
right: SmallMolecule492

CYP4B1 can 12-hydroxylate arachidonic acid
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1356
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14714
xref: UnificationXref14713
left: SmallMolecule812
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1158
right: SmallMolecule492

dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1355
conversion direction: LEFT_TO_RIGHT
xref: RelationshipXref1297
xref: UnificationXref14699
xref: UnificationXref14698
left: SmallMolecule739
left: SmallMolecule1156
left: SmallMolecule299
left: SmallMolecule743
display name: CYP4A11 omega-hydroxylates laurate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1157
right: SmallMolecule492

UniProt:A2ZVF1
type: ProteinReference
xref: UnificationXref13044
organism: http://identifiers.org/taxonomy/4530

CYP26C1 4-hydroxylates 9cRA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1361
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14958
xref: UnificationXref14959
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule1162
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule1163

COX10 transforms heme to heme O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1346
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14508
xref: UnificationXref14507
left: protoheme
left: SmallMolecule1147
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1148
right: SmallMolecule693

RNA primer-DNA primer:origin duplex with DNA damage (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry445
component stoichiometry: Stoichiometry444
component: PhysicalEntity31
component: PhysicalEntity50
xref: UnificationXref2514
cellular location: GO_0005654
comment: Reactome DB_ID: 6261029

Rb1:RNA primer-DNA primer:origin duplex with DNA damage (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry447
component stoichiometry: Stoichiometry446
component: Protein363
component: RNA primer-DNA primer:origin duplex with DNA damage (name copied from entity in Homo sapiens)
xref: UnificationXref2520
cellular location: GO_0005654
comment: Reactome DB_ID: 6261030

Cyclin E:phospho-Cdk2 (Thr 160):phospho-Rb (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry441
component stoichiometry: Stoichiometry440
component: Protein1229
component: Cyclin E:Phosho-Cdk2 (Thr 160) (name copied from entity in Homo sapiens)
xref: UnificationXref2484
cellular location: GO_0005654
comment: Reactome DB_ID: 6263222

E2F1:TFDP1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry443
component stoichiometry: Stoichiometry442
component: Protein843
component: Protein996
xref: UnificationXref2509
cellular location: GO_0005654
comment: Reactome DB_ID: 6261064

CYP3A7 can 6beta-hydroxylate testosterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1353
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14688
xref: UnificationXref14687
left: SmallMolecule739
left: SmallMolecule1154
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1155
right: SmallMolecule492

Cyclin E:Phosho-Cdk2 (Thr 160) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry436
component stoichiometry: Stoichiometry437
component: Protein1228
component: PhysicalEntity48
xref: UnificationXref2477
cellular location: GO_0005654
comment: Reactome DB_ID: 6263218

CYP3A4,5 oxidise AFB1 to AFXBO
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1352
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14634
xref: UnificationXref14633
left: SmallMolecule739
left: SmallMolecule1152
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1153
right: SmallMolecule492

Cyclin E:Phospho-Cdk2(Thr160):Rb complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry438
component stoichiometry: Stoichiometry439
component: Protein363
component: Cyclin E:Phosho-Cdk2 (Thr 160) (name copied from entity in Homo sapiens)
xref: UnificationXref2478
cellular location: GO_0005654
comment: Reactome DB_ID: 6263220

CYP3A4 can N-demethylate loperamide
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1351
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14579
xref: UnificationXref14578
left: SmallMolecule1150
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1151
right: SmallMolecule746
right: SmallMolecule492

COX15 transforms heme O to heme A
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1347
conversion direction: LEFT_TO_RIGHT
EC number: 1.3
xref: UnificationXref14518
xref: UnificationXref14517
left: SmallMolecule1148
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1149

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, Jung-Ja P
author: Wang, M
author: Paschke, R
author: Fu, Zhuji
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

Aborted replication complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry451
component stoichiometry: Stoichiometry452
component: Rb1:RNA primer-DNA primer:origin duplex with DNA damage (name copied from entity in Homo sapiens)
component: E2F1:TFDP1 (name copied from entity in Homo sapiens)
xref: UnificationXref2524
cellular location: GO_0005654
comment: Reactome DB_ID: 6261065

PP2A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry449
component stoichiometry: Stoichiometry448
component stoichiometry: Stoichiometry450
component: Protein1111
component: PhysicalEntity45
component: Protein1119
xref: UnificationXref2521
cellular location: GO_0005654
comment: Reactome DB_ID: 6261053

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref18702

ORC:origin:cyclin B:cdk1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry455
component stoichiometry: Stoichiometry456
component: Complex83
component: Cyclin B:Cdk1 complex (name copied from entity in Homo sapiens)
xref: UnificationXref2530
cellular location: GO_0005654
comment: Reactome DB_ID: 6261062

Cyclin B:Cdk1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry453
component stoichiometry: Stoichiometry454
component: Protein1043
component: Protein371
xref: UnificationXref2529
cellular location: GO_0005654
comment: Reactome DB_ID: 6261061

Activation of gene expression by SREBF (SREBP)
type: Pathway
data source: Provenance1
pathway component: Expression of Lathosterol Oxidase (SC5D, SC5DL)
pathway component: Expression of Squalene Monooxygenase (SQLE)
pathway component: Expression of TM7SF2
pathway component: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
pathway component: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
pathway component: Expression of Farnesyl Diphosphate Synthase (FDPS)
evidence: Evidence859
xref: UnificationXref9810
xref: UnificationXref9809
pathway order: PathwayStep844
pathway order: PathwayStep845
pathway order: PathwayStep789
pathway order: PathwayStep843
pathway order: PathwayStep842
pathway order: PathwayStep782
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1375
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.3
xref: UnificationXref15138
xref: UnificationXref15139
left: Water
left: SmallMolecule1174
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule1177

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1374
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.3
xref: UnificationXref15125
xref: UnificationXref15124
left: SmallMolecule1175
left: DPN
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: NADH
right: SmallMolecule1176

UDP-glucose is oxidised to UDP-glucuronate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1379
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.22
xref: UnificationXref15165
xref: UnificationXref15166
participant stoichiometry: Stoichiometry1555
participant stoichiometry: Stoichiometry1556
participant stoichiometry: Stoichiometry1557
left: Water
left: SmallMolecule270
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule266

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1376
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.1
xref: UnificationXref15148
xref: UnificationXref15147
left: SmallMolecule5
left: SmallMolecule1177
left: coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule7
right: Acetyl coenzyme A

Cytosolic sulfonation of small molecules
type: Pathway
data source: Provenance1
pathway component: REACT 263537.1
pathway component: taurolithocholate + PAPS => taurolithocholate sulfate + PAP
pathway component: lithocholate + PAPS => lithocholate sulfate + PAP
pathway component: dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
pathway component: estrone + PAPS => estrone 3-sulfate + PAP
pathway component: pregnenolone + PAPS => pregnenolone sulfate + PAP
pathway component: 27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
pathway component: cholesterol + PAPS => cholesterol sulfate + PAP
pathway component: 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
pathway component: 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
evidence: Evidence1391
xref: UnificationXref15312
xref: UnificationXref15313
xref: RelationshipXref1331
pathway order: PathwayStep1370
pathway order: PathwayStep482
pathway order: PathwayStep1374
pathway order: PathwayStep1373
pathway order: PathwayStep1368
pathway order: PathwayStep1372
pathway order: PathwayStep1369
pathway order: PathwayStep1371
pathway order: PathwayStep1376
pathway order: PathwayStep1375
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry461
component stoichiometry: Stoichiometry462
component: Protein1228
component: PhysicalEntity41
xref: UnificationXref2584
cellular location: GO_0005654
comment: Reactome DB_ID: 6262736

Cyclin A:Cdk2:phosphorylated substrate complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry465
component stoichiometry: Stoichiometry466
component: PhysicalEntity53
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
xref: UnificationXref2602
cellular location: GO_0005654
comment: Reactome DB_ID: 6263156

CYP4F11 omega-hydroxylates 3-hydroxypalmitate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1364
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14971
xref: UnificationXref14970
left: SmallMolecule739
left: SmallMolecule1164
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1165
right: SmallMolecule492

multi-ubiquitinated phospho-(T286) Cyclin D1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry467
component stoichiometry: Stoichiometry468
component: Protein1303
component: PhysicalEntity24
xref: UnificationXref2637
cellular location: GO_0005829
comment: Reactome DB_ID: 6259749

CYP3A43 catalyzes the 6beta-hydroxylation of testosterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1363
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14963
xref: UnificationXref14962
left: SmallMolecule739
left: SmallMolecule1154
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1155
right: SmallMolecule492

Cohesin:PDS5:WAPAL:Chromosomal Arm (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry470
component stoichiometry: Stoichiometry471
component: Complex71
component: PhysicalEntity21
xref: UnificationXref2644
cellular location: GO_0005654
comment: Reactome DB_ID: 6277827

FMO2 S-oxidizes the antithyroid drug methimazole
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1368
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref14999
xref: UnificationXref14998
left: SmallMolecule739
left: SmallMolecule1169
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule492
right: SmallMolecule1170

FMO1 N-oxidizes the anti-cancer drug tamoxifen
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1367
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.8
xref: UnificationXref14988
xref: UnificationXref14987
left: SmallMolecule739
left: SmallMolecule1166
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1167
right: SmallMolecule492

Cyclin A:Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry458
component stoichiometry: Stoichiometry457
component: Protein1197
component: PhysicalEntity51
xref: UnificationXref2578
cellular location: GO_0005829
comment: Reactome DB_ID: 6262493

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1373
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15118
xref: UnificationXref15119
left: SmallMolecule1173
left: DPN
display name: ethanol + NAD+ => acetaldehyde + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule1174

Cyclin A:Cdk2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry459
component stoichiometry: Stoichiometry460
component: PhysicalEntity41
component: Protein885
xref: UnificationXref2581
cellular location: GO_0005654
comment: Reactome DB_ID: 6262773

Trimethylamine N-oxidised to Trimethylamine-N-oxide
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1369
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.8
xref: UnificationXref15012
xref: UnificationXref15013
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule1171
left: SmallMolecule743
display name: FMO3 N-oxidizes the tertiary amine trimethylamine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule1172
right: SmallMolecule492

Cyclin A:Cdk2:substrate complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry463
component stoichiometry: Stoichiometry464
component: PhysicalEntity52
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
xref: UnificationXref2595
cellular location: GO_0005654
comment: Reactome DB_ID: 6263149

http://identifiers.org/pubmed/20541618
type: PublicationXref
id: 20541618
author: Gilmour, KM
db: Pubmed
title: Perspectives on carbonic anhydrase
source: Comp Biochem Physiol A Mol Integr Physiol 157:193-7
year: 2010

UniProt:Q2QMA5
type: ProteinReference
xref: UnificationXref19832
organism: http://identifiers.org/taxonomy/4530

multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry549
component stoichiometry: Stoichiometry550
component stoichiometry: Stoichiometry551
component: PhysicalEntity11
component: phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity24
xref: UnificationXref2877
cellular location: GO_0005829
comment: Reactome DB_ID: 6263216

multiubiquitinated cell cycle protein:APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry547
component stoichiometry: Stoichiometry546
component: cell cycle proteins:phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity24
xref: UnificationXref2872
cellular location: GO_0005829
comment: Reactome DB_ID: 6262768

26S proteasome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry570
component stoichiometry: Stoichiometry591
component stoichiometry: Stoichiometry571
component stoichiometry: Stoichiometry592
component stoichiometry: Stoichiometry572
component stoichiometry: Stoichiometry573
component stoichiometry: Stoichiometry590
component stoichiometry: Stoichiometry574
component stoichiometry: Stoichiometry575
component stoichiometry: Stoichiometry576
component stoichiometry: Stoichiometry577
component stoichiometry: Stoichiometry578
component stoichiometry: Stoichiometry579
component stoichiometry: Stoichiometry557
component stoichiometry: Stoichiometry558
component stoichiometry: Stoichiometry559
component stoichiometry: Stoichiometry581
component stoichiometry: Stoichiometry580
component stoichiometry: Stoichiometry584
component stoichiometry: Stoichiometry566
component stoichiometry: Stoichiometry585
component stoichiometry: Stoichiometry567
component stoichiometry: Stoichiometry582
component stoichiometry: Stoichiometry564
component stoichiometry: Stoichiometry583
component stoichiometry: Stoichiometry565
component stoichiometry: Stoichiometry588
component stoichiometry: Stoichiometry562
component stoichiometry: Stoichiometry589
component stoichiometry: Stoichiometry563
component stoichiometry: Stoichiometry586
component stoichiometry: Stoichiometry560
component stoichiometry: Stoichiometry587
component stoichiometry: Stoichiometry561
component stoichiometry: Stoichiometry568
component stoichiometry: Stoichiometry569
component: Protein1489
component: Protein1469
component: PhysicalEntity16
component: Protein1540
component: Protein1464
component: Protein1483
component: Protein1504
component: Protein1523
component: Protein1486
component: Protein1461
component: Protein1527
component: Protein1440
component: Protein1443
component: Protein1509
component: Protein1427
component: Protein1447
component: Protein1448
component: Protein1422
component: Protein1539
component: Protein1479
component: Protein1498
component: Protein1536
component: Protein1456
component: Protein1419
component: Protein1494
component: Protein1512
component: Protein1451
component: Protein1513
component: Protein1452
component: Protein1474
component: Protein1514
component: Protein1515
component: Protein1519
component: Protein1432
component: Protein1436
component: Protein1435
xref: UnificationXref3014
cellular location: GO_0005654
comment: Reactome DB_ID: 6262724

multiubiquitinated Cdh1 associated with APC/C (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry554
component stoichiometry: Stoichiometry555
component: PhysicalEntity46
component: phospho-Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
xref: UnificationXref2882
cellular location: GO_0005654
comment: Reactome DB_ID: 6262592

multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry538
component stoichiometry: Stoichiometry539
component: Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity24
xref: UnificationXref2832
cellular location: GO_0005829
comment: Reactome DB_ID: 6262788

Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry536
component stoichiometry: Stoichiometry535
component: Complex67
component: Complex52
xref: UnificationXref2829
cellular location: GO_0005829
comment: Reactome DB_ID: 6262775

cell cycle proteins:phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry544
component stoichiometry: Stoichiometry543
component: phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity58
xref: UnificationXref2869
cellular location: GO_0005829
comment: Reactome DB_ID: 6262761

phospho-APC/C:Cdh1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry541
component stoichiometry: Stoichiometry542
component: Complex68
component: Protein1406
xref: UnificationXref2852
cellular location: GO_0005829
comment: Reactome DB_ID: 6262732

hBUBR1:hBUB3:MAD2* complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry532
component stoichiometry: Stoichiometry534
component stoichiometry: Stoichiometry533
component: Protein969
component: Protein976
component: Protein962
xref: UnificationXref2826
cellular location: GO_0005829
comment: Reactome DB_ID: 6262797

phospho-Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry529
component stoichiometry: Stoichiometry530
component: Protein1284
component: phosphorylated anaphase promoting complex (APC/C) (name copied from entity in Homo sapiens)
xref: UnificationXref2812
cellular location: GO_0005654
comment: Reactome DB_ID: 6262554

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry528
component stoichiometry: Stoichiometry531
component: CCNA:p-T160-CDK2 (name copied from entity in Homo sapiens)
component: phospho-Cdh1:phospho-APC/C complex (name copied from entity in Homo sapiens)
xref: UnificationXref2813
cellular location: GO_0005654
comment: Reactome DB_ID: 6262744

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

UniProt:A2ZVN0
type: ProteinReference
xref: UnificationXref11267
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QLY2
type: ProteinReference
xref: UnificationXref3887
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QLY9
type: ProteinReference
xref: UnificationXref4122
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QLY6
type: ProteinReference
xref: UnificationXref7866
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QLZ0
type: ProteinReference
xref: UnificationXref4120
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QLZ1
type: ProteinReference
xref: UnificationXref4130
organism: http://identifiers.org/taxonomy/4530

Inactivation of APC/C via direct inhibition of the APC/C complex
type: Pathway
data source: Provenance1
pathway component: Binding of the MCC complex to the APC/C complex
pathway component: Formation of the MCC complex
evidence: Evidence144
xref: UnificationXref2057
xref: UnificationXref2056
pathway order: PathwayStep139
pathway order: PathwayStep138
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3209
type: UnificationXref
id: REACT_24442
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24442.2

UnificationXref3207
type: UnificationXref
id: CHEBI:16265
db: ChEBI

UniProt:Q6K2E9
type: ProteinReference
xref: UnificationXref22144
organism: http://identifiers.org/taxonomy/4530

UnificationXref3208
type: UnificationXref
id: 880046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880046

UnificationXref3201
type: UnificationXref
id: CHEBI:30915
db: ChEBI

UnificationXref3202
type: UnificationXref
id: 113594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113594

UnificationXref3200
type: UnificationXref
id: REACT_24360
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24360.1

UnificationXref3205
type: UnificationXref
id: 29390
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29390

UnificationXref3206
type: UnificationXref
id: REACT_3649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3649.2

UnificationXref3203
type: UnificationXref
id: REACT_3871
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3871.2

UnificationXref3204
type: UnificationXref
id: CHEBI:18405
db: ChEBI

UniProt:Q6K2E1
type: ProteinReference
xref: UnificationXref7313
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QMT1
type: ProteinReference
xref: UnificationXref12638
organism: http://identifiers.org/taxonomy/4530

UnificationXref3218
type: UnificationXref
id: 6272531
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272531

UnificationXref3219
type: UnificationXref
id: 6272532
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272532

UnificationXref3210
type: UnificationXref
id: CHEBI:16015
db: ChEBI

UnificationXref3211
type: UnificationXref
id: 113552
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113552

UnificationXref3212
type: UnificationXref
id: REACT_4423
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4423.2

UnificationXref3213
type: UnificationXref
id: Q0D6N1
db: UniProt

UnificationXref3214
type: UnificationXref
id: 6272526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272526

UnificationXref3215
type: UnificationXref
id: OS05T0129100-00
db: Ensembl

UnificationXref3216
type: UnificationXref
id: 6272529
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272529

UnificationXref3217
type: UnificationXref
id: Q6Z3A4
db: UniProt

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

UnificationXref3220
type: UnificationXref
id: 6272533
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272533

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, Pietro
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

UniProt:Q2QMS5
type: ProteinReference
xref: UnificationXref11945
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QN71
type: ProteinReference
xref: UnificationXref16993
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QN70
type: ProteinReference
xref: UnificationXref16999
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QMV8
type: ProteinReference
xref: UnificationXref12634
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

UniProt:Q2QN68
type: ProteinReference
xref: UnificationXref21055
organism: http://identifiers.org/taxonomy/4530

UnificationXref3246
type: UnificationXref
id: REACT_206445
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206445.2

UnificationXref3245
type: UnificationXref
id: 6279825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279825

UnificationXref3244
type: UnificationXref
id: REACT_211253
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211253.2

UnificationXref3243
type: UnificationXref
id: 6279960
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279960

UnificationXref3249
type: UnificationXref
id: REACT_17970
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17970.2

UnificationXref3248
type: UnificationXref
id: 380598
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=380598

UnificationXref3247
type: UnificationXref
id: CHEBI:50157
db: ChEBI

Processive synthesis on the C-strand of the telomere
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction147
pathway component: REACT 258739.1
pathway component: BiochemicalReaction151
pathway component: BiochemicalReaction148
evidence: Evidence252
xref: UnificationXref3078
xref: RelationshipXref104
xref: UnificationXref3077
pathway order: PathwayStep241
pathway order: PathwayStep240
pathway order: PathwayStep245
pathway order: PathwayStep244
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence164
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2470
xref: UnificationXref2469
left: Cyclin E1:Cdk2 complex (name copied from entity in Homo sapiens)
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Cyclin E1:phospho-Cdk2 complex (name copied from entity in Homo sapiens)
right: Adenosine 5'-diphosphate

Translocation of Cyclin E:Cdk2 complex to the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence163
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2463
xref: UnificationXref2464
left: Cyclin E:Cdk2 complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Cyclin E:Cdk2 complexes (name copied from entity in Homo sapiens)

UniProt:Q2QMX9
type: ProteinReference
xref: UnificationXref5505
organism: http://identifiers.org/taxonomy/4530

Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence158
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2383
xref: UnificationXref2384
left: SCF(Skp2):Cks1 complex (name copied from entity in Homo sapiens)
left: Protein1125
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 (name copied from entity in Homo sapiens)

Dephosphorylation of p130 (RBL2) by PP2A
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence157
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.16
xref: UnificationXref2315
xref: UnificationXref2314
participant stoichiometry: Stoichiometry413
participant stoichiometry: Stoichiometry414
left: Water
left: Protein1125
display name: Dephosphorylation of p107 by PP2A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein1020
right: Phosphate

UniProt:Q2QN95
type: ProteinReference
xref: UnificationXref3181
organism: http://identifiers.org/taxonomy/4530

Formation of Cyclin E:Cdk2 complexes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence162
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2461
xref: UnificationXref2460
left: Protein1197
left: PhysicalEntity47
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Cyclin E:Cdk2 complex (name copied from entity in Homo sapiens)

Ubiquitination of p130 (RBL2) by SCF (Skp2)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence159
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: UnificationXref2424
xref: UnificationXref2423
left: p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 (name copied from entity in Homo sapiens)
left: PhysicalEntity46
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SCF(Skp2):Cks1 complex (name copied from entity in Homo sapiens)
right: Ub-p-T401,S672,1035-RBL2 (name copied from entity in Homo sapiens)

UnificationXref3252
type: UnificationXref
id: CHEBI:27823
db: ChEBI

UnificationXref3253
type: UnificationXref
id: 380593
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=380593

UnificationXref3250
type: UnificationXref
id: 113529
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529

UnificationXref3251
type: UnificationXref
id: REACT_5847
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5847.1

UnificationXref3255
type: UnificationXref
id: O24174
db: UniProt

UnificationXref3254
type: UnificationXref
id: REACT_17511
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17511.2

UnificationXref3257
type: UnificationXref
id: 6256860
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6256860

UnificationXref3256
type: UnificationXref
id: 6256859
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6256859

UnificationXref3259
type: UnificationXref
id: REACT_246852
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246852.1

UnificationXref3258
type: UnificationXref
id: 6267868
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267868

UnificationXref3260
type: UnificationXref
id: 6279848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279848

UnificationXref3261
type: UnificationXref
id: REACT_249089
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249089.1

UnificationXref3262
type: UnificationXref
id: 6279849
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279849

UnificationXref3263
type: UnificationXref
id: REACT_245906
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245906.1

UnificationXref3264
type: UnificationXref
id: 6279850
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279850

UnificationXref3228
type: UnificationXref
id: REACT_2390
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2390.1

http://identifiers.org/pubmed/11278283
type: PublicationXref
id: 11278283
author: Tsubuki, S
author: Lee, KK
author: Yajima, N
author: Ohyama, T
author: Yonehara, S
db: Pubmed
title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
source: J Biol Chem 276:19276-85
year: 2001

UnificationXref3227
type: UnificationXref
id: 29362
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29362

UnificationXref3226
type: UnificationXref
id: REACT_4970
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4970.1

UnificationXref3225
type: UnificationXref
id: 113526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113526

UnificationXref3224
type: UnificationXref
id: REACT_3290
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3290.1

UnificationXref3223
type: UnificationXref
id: 113521
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521

UnificationXref3222
type: UnificationXref
id: REACT_224915
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224915.2

UnificationXref3221
type: UnificationXref
id: 6272535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272535

MAD2 associates with the Mad1 kinetochore complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence136
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2017
xref: UnificationXref2018
left: Mad1:kinetochore complex (name copied from entity in Homo sapiens)
left: Protein962
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Kinetochore:Mad1:MAD2 Complex (name copied from entity in Homo sapiens)

MAD2 converted to an inhibitory state via interaction with Mad1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence137
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2020
xref: UnificationXref2019
left: Kinetochore:Mad1:MAD2 Complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Kinetochore:Mad1:MAD2 Complex (name copied from entity in Homo sapiens)

UnificationXref3229
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Release of activated MAD2 from kinetochores
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence138
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2022
xref: UnificationXref2021
left: Kinetochore:Mad1:MAD2 Complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Mad1:kinetochore complex (name copied from entity in Homo sapiens)
right: Protein962

Removal of remaining Flap
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence113
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1924
xref: UnificationXref1925
left: Processive complex:Okazaki fragments:Remaining Flap (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex:nicked DNA from adjacent Okazaki fragments (name copied from entity in Homo sapiens)

Recruitment of Dna2 endonuclease
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence112
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1912
xref: UnificationXref1911
left: Processive complex:Okazaki fragment:Flap:RPA heterotrimer (name copied from entity in Homo sapiens)
left: Protein937
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 (name copied from entity in Homo sapiens)

Phosphorylation of COP1 at Ser-387 by ATM
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence124
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1967
xref: UnificationXref1966
left: Protein942
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein947
right: Adenosine 5'-diphosphate

Joining of adjacent Okazaki fragments
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence115
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1933
xref: UnificationXref1932
left: PhysicalEntity34
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity38

Autoubiquitination of phospho-COP1(Ser-387 )
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence126
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: UnificationXref1977
xref: UnificationXref1976
participant stoichiometry: Stoichiometry368
left: Protein953
left: PhysicalEntity24
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: ubiquitinated phospho-COP1(ser-387) (name copied from entity in Homo sapiens)

Translocation of COP1 from the nucleus to the cytoplasm
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence125
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1974
xref: UnificationXref1973
left: Protein947
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein953

Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence133
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1998
xref: UnificationXref1997
left: SmallMolecule5
left: CCNB:CDK1 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: CCNB:p-T14-CDK1 (name copied from entity in Homo sapiens)

Proteasome mediated degradation of COP1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence127
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1979
xref: UnificationXref1978
participant stoichiometry: Stoichiometry371
left: ubiquitinated phospho-COP1(ser-387) (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity24

UnificationXref3230
type: UnificationXref
id: 113536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113536

UnificationXref3231
type: UnificationXref
id: REACT_2775
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2775.2

UnificationXref3237
type: UnificationXref
id: 6272317
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272317

UnificationXref3236
type: UnificationXref
id: Q6Z9G0
db: UniProt

UnificationXref3239
type: UnificationXref
id: 6272320
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272320

UnificationXref3238
type: UnificationXref
id: 6272318
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272318

UnificationXref3233
type: UnificationXref
id: 6272313
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272313

UnificationXref3232
type: UnificationXref
id: Q84PC4
db: UniProt

UnificationXref3235
type: UnificationXref
id: 6272315
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272315

UnificationXref3234
type: UnificationXref
id: B9G153
db: UniProt

p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence154
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2275
xref: UnificationXref2274
left: RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
left: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)

Dephosphorylation of p107 (RBL1) by PP2A
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence156
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.16
xref: UnificationXref2310
xref: UnificationXref2309
participant stoichiometry: Stoichiometry409
participant stoichiometry: Stoichiometry408
left: Protein1108
left: Water
display name: Dephosphorylation of p107 by PP2A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein993
right: Phosphate

p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence152
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2269
xref: UnificationXref2268
left: RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
left: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)

p130 (RBL2) binds Cyclin E/A:CDK2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence153
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2271
xref: UnificationXref2272
left: Protein1020
left: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RBL2:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)

HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence148
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2125
xref: UnificationXref2124
left: Protein980
left: RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)
display name: Recruitment of HDAC1 by p107 (RBL1)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: HDAC1:RBL1:E2F4:TFDP1,TFDP2 (name copied from entity in Homo sapiens)

Binding of the MCC complex to the APC/C complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence143
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2054
xref: UnificationXref2055
left: Complex68
left: hBUBR1:hBUB3:MAD2*:CDC20 complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: MCC:APC/C complex (name copied from entity in Homo sapiens)

Formation of the MCC complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence142
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2052
xref: UnificationXref2051
left: Protein589
left: Protein969
left: Protein976
left: Protein962
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hBUBR1:hBUB3:MAD2*:CDC20 complex (name copied from entity in Homo sapiens)

Inactivation of APC/C via CDC20 sequestration
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence141
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2028
xref: UnificationXref2029
left: Protein589
left: Protein962
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: MAD2*CDC20 complex (name copied from entity in Homo sapiens)

p107 (RBL1) binds CyclinE/A:CDK2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence151
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2265
xref: UnificationXref2266
left: Protein993
left: Cyclin E/A:Cdk2 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RBL1:Cyclin E/A:CDK2 (name copied from entity in Homo sapiens)

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence150
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2217
xref: UnificationXref2216
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein1043
right: Protein1035
right: PhysicalEntity41
right: Protein843

HDAC1 + p130(RBL2):E2F4/5:DP1 => HDAC1-p130(RBL2):E2F4/5:DP1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence149
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref2144
xref: UnificationXref2145
left: Protein980
left: RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)
display name: Recruitment of HDAC1 by p130 (RBL2)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: HDAC1:RBL2:E2F4/5:DP1/2 (name copied from entity in Homo sapiens)

UnificationXref3240
type: UnificationXref
id: REACT_226460
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226460.2

UnificationXref3241
type: UnificationXref
id: 6279959
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279959

UnificationXref3242
type: UnificationXref
id: REACT_222250
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222250.2

Visual phototransduction
type: Pathway
data source: Provenance1
pathway component: REACT 212063.2
pathway component: REACT 215639.2
pathway component: REACT 255794.1
evidence: Evidence537
xref: UnificationXref6565
xref: UnificationXref6564
xref: RelationshipXref345
pathway order: PathwayStep517
pathway order: PathwayStep525
pathway order: PathwayStep515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3291
type: UnificationXref
id: 6266821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266821

UnificationXref3290
type: UnificationXref
id: 6266819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266819

UnificationXref3293
type: UnificationXref
id: 6266825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266825

UnificationXref3292
type: UnificationXref
id: 6266824
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266824

UnificationXref3295
type: UnificationXref
id: REACT_212922
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212922.2

UnificationXref3294
type: UnificationXref
id: 6266827
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266827

UnificationXref3297
type: UnificationXref
id: REACT_243724
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243724.1

UnificationXref3296
type: UnificationXref
id: 6279389
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279389

UnificationXref3287
type: UnificationXref
id: 6266812
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266812

UnificationXref3288
type: UnificationXref
id: 6266814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266814

http://identifiers.org/pubmed/15611369
type: PublicationXref
id: 15611369
author: O'Donnell, CJ
author: Grant, SW
author: Cupples, LA
author: Waterman, MR
author: Brown, NJ
author: Demissie, S
author: Wang, Y
author: Womble, KE
author: Capdevila, JH
author: Gainer, JV
author: Bellamine, A
author: Dawson, EP
author: Guo, CY
db: Pubmed
title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension
source: Circulation 111:63-9
year: 2005

UnificationXref3289
type: UnificationXref
id: 6266816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266816

UniProt:Q2QMK8
type: ProteinReference
xref: UnificationXref7687
organism: http://identifiers.org/taxonomy/4530

Cleavage of 5-hydroxyluracil by UNG2 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1468
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15910
xref: UnificationXref15909
left: Complex753
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1269
right: Complex757

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

Cleavage of uracil by MBD4 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1469
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15912
xref: UnificationXref15913
left: Complex756
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1268
right: Complex758

Cleavage of thymine by MBD4 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1470
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15916
xref: UnificationXref15917
left: Complex755
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex758
right: SmallMolecule1270

Displacement of UNG2 glycosylase by APE1 at the AP site
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1474
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15934
xref: UnificationXref15935
left: Complex757
left: Protein5890
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein5873
right: Complex759

Cleavage of uracil by UNG2 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1467
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15904
xref: UnificationXref15905
left: Complex754
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1268
right: Complex757

APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1480
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15950
xref: UnificationXref15949
left: Complex759
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex760

Displacement of hOGG1 glycosylase by APE1 at the AP site
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1476
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15938
xref: UnificationXref15939
left: Protein5890
left: Complex752
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex759
right: Protein5869

Displacement of MBD4 glycosylase by APE1 at the AP site
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1475
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15936
xref: UnificationXref15937
left: Complex758
left: Protein5890
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein5887
right: Complex759

Displacement of MPG glycosylase by APE1 at the AP site
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1478
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15942
xref: UnificationXref15943
left: Protein5890
left: Complex751
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein5862
right: Complex759

Displacement of MYH glycosylase by APE1 at the AP site
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1477
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15941
xref: UnificationXref15940
left: Complex750
left: Protein5890
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein5865
right: Complex759

UnificationXref3298
type: UnificationXref
id: 6279390
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279390

UnificationXref3299
type: UnificationXref
id: REACT_233057
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233057.1

UnificationXref3273
type: UnificationXref
id: Q4W8D0
db: UniProt

UnificationXref3272
type: UnificationXref
id: 6255695
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255695

UniProt:Q6K1Y8
type: ProteinReference
xref: UnificationXref11082
organism: http://identifiers.org/taxonomy/4530

UnificationXref3275
type: UnificationXref
id: P14655
db: UniProt

UnificationXref3274
type: UnificationXref
id: 6255698
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255698

UnificationXref3271
type: UnificationXref
id: P14654
db: UniProt

UnificationXref3270
type: UnificationXref
id: REACT_4309
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4309.3

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

UnificationXref3269
type: UnificationXref
id: 29404
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29404

UniProt:Q6K1Z1
type: ProteinReference
xref: UnificationXref2180
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K1Z6
type: ProteinReference
xref: UnificationXref2194
organism: http://identifiers.org/taxonomy/4530

UnificationXref3265
type: UnificationXref
id: REACT_263295
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263295.1

UnificationXref3266
type: UnificationXref
id: CHEBI:28938
db: ChEBI

UnificationXref3267
type: UnificationXref
id: 31633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31633

UnificationXref3268
type: UnificationXref
id: REACT_2447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2447.1

UnificationXref3286
type: UnificationXref
id: 6266809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266809

UnificationXref3285
type: UnificationXref
id: 6266807
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266807

UnificationXref3284
type: UnificationXref
id: 6266804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266804

UnificationXref3283
type: UnificationXref
id: 6266801
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266801

UnificationXref3282
type: UnificationXref
id: REACT_210404
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210404.2

UnificationXref3281
type: UnificationXref
id: 6255708
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255708

UnificationXref3280
type: UnificationXref
id: 6255706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255706

Toll Like Receptor 2 (TLR2) Cascade
type: Pathway
data source: Provenance1
pathway component: REACT 206979.2
pathway component: REACT 204137.2
evidence: Evidence2137
xref: UnificationXref23097
xref: UnificationXref23096
xref: RelationshipXref1745
pathway order: PathwayStep2110
pathway order: PathwayStep2111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3278
type: UnificationXref
id: 6255704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255704

UnificationXref3279
type: UnificationXref
id: 6255705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255705

UnificationXref3276
type: UnificationXref
id: 6255701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6255701

UnificationXref3277
type: UnificationXref
id: P14656
db: UniProt

AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1423
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15642
xref: UnificationXref15643
left: SmallMolecule407
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1250

Carbonic anhydrase I/II dehydrates bicarbonate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1422
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15640
xref: UnificationXref15641
left: hydrogencarbonate
left: proton
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: Water

UniProt:Q2QN13
type: ProteinReference
xref: UnificationXref19531
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K1W6
type: ProteinReference
xref: UnificationXref18273
organism: http://identifiers.org/taxonomy/4530

UniProt:E2DXN3
type: ProteinReference
xref: UnificationXref3369
organism: http://identifiers.org/taxonomy/4530

Carbonic anhydrase hydrates carbon dioxide (cytosol)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1435
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15700
xref: UnificationXref15699
left: SmallMolecule407
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hydrogencarbonate
right: proton

Carbonic anhydrase dehydrates bicarbonate (cytosol)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1436
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15702
xref: UnificationXref15701
left: hydrogencarbonate
left: proton
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: Water

carbovir + IMP => carbovir monophosphate + inosine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1431
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.77
xref: UnificationXref15679
xref: UnificationXref15678
left: SmallMolecule1257
left: SmallMolecule891
display name: Conversion of carbovir to carbovir monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1256
right: SmallMolecule931

carbovir monophosphate + ATP => carbovir diphosphate + ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1432
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15684
xref: UnificationXref15683
left: SmallMolecule1256
left: SmallMolecule5
display name: Phosphorylation of carbovir monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1258
right: SmallMolecule6

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1429
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.1
xref: UnificationXref15662
xref: UnificationXref15663
participant stoichiometry: Stoichiometry1617
participant stoichiometry: Stoichiometry1615
participant stoichiometry: Stoichiometry1616
left: SmallMolecule1251
left: DPN
display name: Oxidation of abacavir to abacavir 5'-carboxylate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule1253

abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1430
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.4
xref: UnificationXref15674
xref: UnificationXref15673
left: Water
left: SmallMolecule1254
display name: Deamination of abacavir monophosphate to form carbovir monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1256
right: SmallMolecule1255

UniProt:A2ZVY5
type: ProteinReference
xref: UnificationXref22506
organism: http://identifiers.org/taxonomy/4530

abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1426
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.3.44
xref: UnificationXref15653
xref: UnificationXref15654
left: Water
left: SmallMolecule5
left: SmallMolecule1251
display name: ABCG2-mediated abacavir efflux
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule1252

abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1427
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.3.44
xref: UnificationXref15656
xref: UnificationXref15655
left: Water
left: SmallMolecule5
left: SmallMolecule1251
display name: ABCB1-mediated abacavir efflux
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule1252

AKR dimers reduce AFBDHO to AFBDOH
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1407
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15537
xref: UnificationXref15536
left: proton
left: NADPH
left: SmallMolecule1242
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule1243

http://identifiers.org/pubmed/8330735
type: PublicationXref
id: 8330735
author: Hernandez, N
db: Pubmed
title: TBP, a universal eukaryotic transcription factor?
source: Genes Dev 7:1291-308
year: 1993

UniProt:Q2QN04
type: ProteinReference
xref: UnificationXref7482
organism: http://identifiers.org/taxonomy/4530

Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1421
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15639
xref: UnificationXref15638
left: hydrogencarbonate
left: Chloride
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hydrogencarbonate
right: Chloride

FXN:NFS1:ISD11:ISCU assembles iron-sulfur cluster
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1415
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.1.7
xref: UnificationXref15613
xref: UnificationXref15614
participant stoichiometry: Stoichiometry1608
participant stoichiometry: Stoichiometry1609
participant stoichiometry: Stoichiometry1601
participant stoichiometry: Stoichiometry1602
left: SmallMolecule1248
left: Complex721
left: Complex726
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex725
right: SmallMolecule963
right: Complex727

AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1417
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15619
xref: UnificationXref15620
left: SmallMolecule1250
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407

Carbonic anhydrase I/II hydrates carbon dioxide
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1418
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15631
xref: UnificationXref15632
left: SmallMolecule407
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hydrogencarbonate
right: proton

Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic bicarbonate for extracellular chloride
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1419
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15635
xref: UnificationXref15634
left: hydrogencarbonate
left: Chloride
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hydrogencarbonate
right: Chloride

Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1410
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15556
xref: UnificationXref15557
left: SmallMolecule1244
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule363

Frataxin binds iron
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1411
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15582
xref: UnificationXref15581
participant stoichiometry: Stoichiometry1577
left: Complex719
left: SmallMolecule363
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex721

NADPH transfers electrons to FDXR
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1412
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15588
xref: UnificationXref15587
left: H+
left: Complex723
left: SmallMolecule857
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex724
right: SmallMolecule859

FDXR transfers electrons to FDX1/1L
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1413
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15604
xref: UnificationXref15605
participant stoichiometry: Stoichiometry1599
participant stoichiometry: Stoichiometry1596
participant stoichiometry: Stoichiometry1600
left: Complex724
left: Complex725
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: Complex723
right: Complex726

UniProt:Q2QN30
type: ProteinReference
xref: UnificationXref4787
organism: http://identifiers.org/taxonomy/4530

Cleavage of hypoxanthine by MPG glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1457
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15846
xref: UnificationXref15847
left: Complex746
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1266
right: Complex751

Cleavage of ethenoadenine by MPG glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1456
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15842
xref: UnificationXref15843
left: Complex745
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex751
right: SmallMolecule1265

Cleavage of 3-methyladenine by MPG glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1455
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15837
xref: UnificationXref15838
left: Complex744
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex751
right: SmallMolecule1264

Cleavage 8-oxo guanine by MYH glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1454
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15831
xref: UnificationXref15832
left: Complex747
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex750
right: SmallMolecule1263

UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1462
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15878
xref: UnificationXref15877
left: Protein5873
left: PhysicalEntity173
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex753

UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1463
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15882
xref: UnificationXref15883
left: Protein5873
left: PhysicalEntity174
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex754

Cleavage of 8-oxo guanine by hOGG1 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1458
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.2.23
xref: UnificationXref15849
xref: UnificationXref15850
left: Complex748
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1263
right: Complex752

Cleavage of formamidopyrimidine by hOGG1 glycosylase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1459
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.2.23
xref: UnificationXref15854
xref: UnificationXref15855
left: Complex749
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1267
right: Complex752

MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1464
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15892
xref: UnificationXref15893
left: Protein5887
left: PhysicalEntity175
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex755

MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1465
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15898
xref: UnificationXref15897
left: Protein5887
left: PhysicalEntity176
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex756

Carbonic anhydrase hydrates carbon dioxide (mitochondria)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1437
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15718
xref: UnificationXref15717
left: Water
left: SmallMolecule666
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule1050

NADPH reduces NDOR1:CIAPIN1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1440
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15742
xref: UnificationXref15743
left: NADPH
left: Complex739
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: NADP+
right: Complex742

Carbonic anhydrase dehydrates bicarbonate (mitochondria)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1438
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.1
xref: UnificationXref15720
xref: UnificationXref15719
left: H+
left: SmallMolecule1050
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule666

UniProt:Q2QN26
type: ProteinReference
xref: UnificationXref2166
organism: http://identifiers.org/taxonomy/4530

Signaling by FGFR in disease
type: Pathway
data source: Provenance1
pathway component: REACT 210396.2
pathway component: REACT 261734.1
evidence: Evidence479
xref: UnificationXref6191
xref: UnificationXref6190
pathway order: PathwayStep458
pathway order: PathwayStep467
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

MT-MMPs are sorted to the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1443
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15766
xref: UnificationXref15767
left: PhysicalEntity164
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity165

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

MPG glycosylase mediated recognition and binding of 3-methyladenine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1447
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15782
xref: UnificationXref15783
left: Protein5862
left: PhysicalEntity166
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex744

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

MPG glycosylase mediated recognition and binding of ethenoadenine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1448
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15788
xref: UnificationXref15787
left: Protein5862
left: PhysicalEntity167
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex745

MPG glycosylase mediated recognition and binding of hypoxanthine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1449
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15793
xref: UnificationXref15792
left: Protein5862
left: PhysicalEntity168
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex746

MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1450
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15805
xref: UnificationXref15804
left: PhysicalEntity169
left: Protein5865
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex747

hOGG1 glycosylase mediated recognition and binding of an 8-oxo guanine opposite to a cytosine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1451
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15817
xref: UnificationXref15816
left: Protein5869
left: PhysicalEntity170
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex748

hOGG1 glycosylase mediated recognition and binding of a formamidopyrimidine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1452
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref15822
xref: UnificationXref15821
left: Protein5869
left: PhysicalEntity171
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex749

UniProt:Q6K376
type: ProteinReference
xref: UnificationXref3510
organism: http://identifiers.org/taxonomy/4530

di-mu-sulfido-diiron(2+) [ChEBI:33737]
type: SmallMoleculeReference
name: [Fe2S2](2+)
name: [2Fe-2S](2+)
name: di-mu-sulfido-diiron(2+)
name: [Fe2(mu-S)2](2+)
xref: UnificationXref15589

http://identifiers.org/pubmed/9949182
type: PublicationXref
id: 9949182
author: Pébusque, MJ
author: Grégoire, MJ
author: Zhang, B
author: Jonveaux, P
author: Popovici, C
author: Lafage-Pochitaloff, M
author: Birnbaum, D
db: Pubmed
title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
source: Blood 93:1381-9
year: 1999

[Fe2S2](+)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(1+)
name: [2Fe-2S](1+)
name: di-mu-sulfido-diiron(1+) [ChEBI:33738]
name: [Fe2(mu-S)2](+)
xref: UnificationXref15600

[Fe2(mu-S)2](0)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(0) [ChEBI:33739]
name: di-mu-sulfido-diiron(0)
name: 2Fe-2S cluster
name: [Fe2S2](0)
xref: UnificationXref15609

http://identifiers.org/pubmed/8250832
type: PublicationXref
id: 8250832
author: Serhan, CN
author: Takahashi, Y
author: Chen, XS
author: Yamamoto, S
author: Romano, M
author: Funk, CD
db: Pubmed
title: Lipoxin synthase activity of human platelet 12-lipoxygenase
source: Biochem J 296:127-33
year: 1993

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

http://identifiers.org/pubmed/7925341
type: PublicationXref
id: 7925341
author: Bandoh, S
author: Takeda, O
author: Takahashi, E
author: Tanabe, T
author: Ihara, H
author: Miyata, A
author: Yokoyama, C
db: Pubmed
title: Characterization of the human gene (TBXAS1) encoding thromboxane synthase
source: Eur J Biochem 224:273-9
year: 1994

UniProt:Q2QNF3
type: ProteinReference
xref: UnificationXref17981
organism: http://identifiers.org/taxonomy/4530

Acyl chain remodelling of PS
type: Pathway
data source: Provenance1
pathway component: 1-acyl LPS is acylated to PS by LPSAT
pathway component: 2-acyl LPS is acylated to PS by LPSAT
evidence: Evidence925
xref: UnificationXref10378
xref: UnificationXref10379
xref: RelationshipXref765
pathway order: PathwayStep911
pathway order: PathwayStep910
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

The NLRP3 inflammasome
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1357
pathway component: BiochemicalReaction1358
evidence: Evidence2141
xref: UnificationXref23111
xref: UnificationXref23110
pathway order: PathwayStep2114
pathway order: PathwayStep2115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNG7
type: ProteinReference
xref: UnificationXref8649
organism: http://identifiers.org/taxonomy/4530

UniProt:A2ZWI8
type: ProteinReference
xref: UnificationXref2096
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNH0
type: ProteinReference
xref: UnificationXref3819
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

http://identifiers.org/pubmed/8131753
type: PublicationXref
id: 8131753
author: Lieber, MR
author: Harrington, JJ
db: Pubmed
title: The characterization of a mammalian DNA structure-specific endonuclease.
source: EMBO J 13:1235-46
year: 1994

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

UniProt:Q6K2Q1
type: ProteinReference
xref: UnificationXref1228
organism: http://identifiers.org/taxonomy/4530

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref7717

http://identifiers.org/pubmed/11294880
type: PublicationXref
id: 11294880
author: Lytton, J
author: Li, XF
author: Quednau, BD
author: Yang, R
author: Cai, X
author: Kraev, A
author: Leach, S
author: Perizzolo, M
author: Winkfein, R
author: Dong, H
author: Philipson, KD
db: Pubmed
title: Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3
source: J Biol Chem 276:23161-72
year: 2001

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

UniProt:Q2QNJ8
type: ProteinReference
xref: UnificationXref18945
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K2P9
type: ProteinReference
xref: UnificationXref18482
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K2P8
type: ProteinReference
xref: UnificationXref18484
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNK2
type: ProteinReference
xref: UnificationXref5872
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNK1
type: ProteinReference
xref: UnificationXref5878
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

UniProt:A2ZWP5
type: ProteinReference
xref: UnificationXref8616
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

UniProt:Q6K2K4
type: ProteinReference
xref: UnificationXref22170
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K2K1
type: ProteinReference
xref: UnificationXref13940
organism: http://identifiers.org/taxonomy/4530

chromosome, centromeric region
type: CellularLocationVocabulary
xref: UnificationXref1538

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

N-glycan antennae elongation in the medial/trans-Golgi
type: Pathway
data source: Provenance1
pathway component: REACT 238490.1
pathway component: REACT 221989.2
evidence: Evidence1850
xref: UnificationXref19878
xref: UnificationXref19879
pathway order: PathwayStep1825
pathway order: PathwayStep1828
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

L-arginine removal
type: SequenceModificationVocabulary
xref: UnificationXref6574

UniProt:Q2QNB5
type: ProteinReference
xref: UnificationXref21430
organism: http://identifiers.org/taxonomy/4530

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref8006

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

UnificationXref3304
type: UnificationXref
id: 6270247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270247

UnificationXref3305
type: UnificationXref
id: 6270249
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270249

UnificationXref3302
type: UnificationXref
id: Q9AUR9
db: UniProt

UnificationXref3303
type: UnificationXref
id: 6270246
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270246

Steroid hormones
type: Pathway
data source: Provenance1
pathway component: REACT 262465.1
pathway component: REACT 245235.1
pathway component: REACT 255646.1
evidence: Evidence42
xref: UnificationXref736
xref: UnificationXref735
pathway order: PathwayStep33
pathway order: PathwayStep36
pathway order: PathwayStep40
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3300
type: UnificationXref
id: Q10E16
db: UniProt

UnificationXref3301
type: UnificationXref
id: 6270244
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270244

UnificationXref3308
type: UnificationXref
id: 6270254
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270254

UnificationXref3309
type: UnificationXref
id: REACT_174590
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_174590.3

UnificationXref3306
type: UnificationXref
id: 6270251
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270251

UnificationXref3307
type: UnificationXref
id: 6270252
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6270252

UnificationXref10963
type: UnificationXref
id: REACT_243525
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243525.1

UnificationXref10962
type: UnificationXref
id: 6277023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277023

UnificationXref10965
type: UnificationXref
id: 2046065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046065

UnificationXref10964
type: UnificationXref
id: CHEBI:63543
db: ChEBI

UnificationXref10961
type: UnificationXref
id: 6277000
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277000

UnificationXref10960
type: UnificationXref
id: REACT_124032
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124032.1

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

UnificationXref10967
type: UnificationXref
id: 6277014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277014

UnificationXref10966
type: UnificationXref
id: REACT_124787
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124787.1

UnificationXref10969
type: UnificationXref
id: CHEBI:63540
db: ChEBI

UnificationXref10968
type: UnificationXref
id: REACT_247035
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247035.1

UnificationXref3313
type: UnificationXref
id: REACT_212470
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212470.2

UnificationXref3314
type: UnificationXref
id: 6279920
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279920

UnificationXref3315
type: UnificationXref
id: REACT_203056
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203056.2

UnificationXref3316
type: UnificationXref
id: 6279921
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279921

UnificationXref3310
type: UnificationXref
id: 6279918
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279918

UnificationXref3311
type: UnificationXref
id: REACT_205169
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205169.2

UnificationXref3312
type: UnificationXref
id: 6279919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279919

UniProt:A2ZWZ6
type: ProteinReference
xref: UnificationXref9549
organism: http://identifiers.org/taxonomy/4530

UnificationXref3317
type: UnificationXref
id: REACT_219817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219817.2

UnificationXref3318
type: UnificationXref
id: 6279391
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279391

UnificationXref3319
type: UnificationXref
id: REACT_214616
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_214616.2

UnificationXref10976
type: UnificationXref
id: 211606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211606

UnificationXref10975
type: UnificationXref
id: REACT_124358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124358.1

UnificationXref10974
type: UnificationXref
id: 2046047
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046047

UnificationXref10973
type: UnificationXref
id: REACT_260868
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260868.1

UnificationXref10972
type: UnificationXref
id: 6277022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277022

UnificationXref10971
type: UnificationXref
id: REACT_123619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123619.1

UnificationXref10970
type: UnificationXref
id: 2046054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046054

UnificationXref10979
type: UnificationXref
id: REACT_217203
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_217203.2

UnificationXref10978
type: UnificationXref
id: 6277010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277010

UnificationXref10977
type: UnificationXref
id: REACT_23217
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23217.1

UnificationXref3322
type: UnificationXref
id: 6274052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274052

UnificationXref3323
type: UnificationXref
id: Q0DNE3
db: UniProt

UnificationXref3320
type: UnificationXref
id: Q5ZAU3
db: UniProt

UnificationXref3321
type: UnificationXref
id: 6274051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274051

UnificationXref3326
type: UnificationXref
id: 6274057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274057

UnificationXref3327
type: UnificationXref
id: 6274058
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274058

STING mediated induction of host immune responses
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1360
evidence: Evidence2147
xref: RelationshipXref1747
xref: UnificationXref23152
xref: UnificationXref23153
pathway order: PathwayStep2121
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3324
type: UnificationXref
id: 6274055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274055

UnificationXref3325
type: UnificationXref
id: B9F5T0
db: UniProt

UniProt:Q2QNV0
type: ProteinReference
xref: UnificationXref4727
organism: http://identifiers.org/taxonomy/4530

UnificationXref3328
type: UnificationXref
id: 6274059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274059

UnificationXref3329
type: UnificationXref
id: B9F3N3
db: UniProt

UnificationXref10941
type: UnificationXref
id: REACT_124715
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124715.1

UnificationXref10940
type: UnificationXref
id: 2046066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046066

UnificationXref10943
type: UnificationXref
id: REACT_2882
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2882.1

UnificationXref10942
type: UnificationXref
id: 113601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113601

UnificationXref10945
type: UnificationXref
id: REACT_3979
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3979.1

UnificationXref10944
type: UnificationXref
id: 159751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159751

UnificationXref10947
type: UnificationXref
id: 2046051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046051

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

UnificationXref10946
type: UnificationXref
id: CHEBI:63542
db: ChEBI

UnificationXref3330
type: UnificationXref
id: 6274062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274062

UnificationXref10949
type: UnificationXref
id: 113564
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113564

UnificationXref10948
type: UnificationXref
id: REACT_124125
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124125.1

UnificationXref3331
type: UnificationXref
id: 6274063
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274063

UnificationXref3332
type: UnificationXref
id: Q75HP9
db: UniProt

UnificationXref3333
type: UnificationXref
id: 6274066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274066

UnificationXref3334
type: UnificationXref
id: 6274067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274067

UnificationXref3335
type: UnificationXref
id: 6274068
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274068

UnificationXref3336
type: UnificationXref
id: CHEBI:17489
db: ChEBI

http://identifiers.org/pubmed/7890667
type: PublicationXref
id: 7890667
author: Liu, SM
author: Cheng, HF
author: Wong, LP
author: King, K
author: Jiang, MJ
author: Chen, CL
author: Lomasney, JW
db: Pubmed
title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
source: J Biol Chem 270:5495-505
year: 1995

UnificationXref3337
type: UnificationXref
id: 30389
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30389

UnificationXref3338
type: UnificationXref
id: REACT_3751
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3751.2

UnificationXref3339
type: UnificationXref
id: 6274069
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274069

UnificationXref10950
type: UnificationXref
id: REACT_2334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2334.1

UniProt:Q2R065
type: ProteinReference
xref: UnificationXref20913
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2R066
type: ProteinReference
xref: UnificationXref20917
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/19073728
type: PublicationXref
id: 19073728
author: Lenschow, DJ
author: Virgin, HW
author: Giannakopoulos, NV
author: Lai, C
author: Haas, AL
author: Arutyunova, E
db: Pubmed
title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
source: J Virol 83:1602-10
year: 2009

UnificationXref10954
type: UnificationXref
id: 2046059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046059

UnificationXref10953
type: UnificationXref
id: CHEBI:63539
db: ChEBI

UnificationXref10952
type: UnificationXref
id: REACT_232116
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232116.1

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref10951
type: UnificationXref
id: 6277011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277011

UnificationXref10958
type: UnificationXref
id: CHEBI:63541
db: ChEBI

UnificationXref10957
type: UnificationXref
id: REACT_241334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241334.1

UnificationXref10956
type: UnificationXref
id: 6277013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277013

UnificationXref10955
type: UnificationXref
id: REACT_123220
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123220.1

UnificationXref3341
type: UnificationXref
id: REACT_235007
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235007.1

UnificationXref3340
type: UnificationXref
id: 6274116
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274116

UnificationXref10959
type: UnificationXref
id: 2046057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046057

Neurotransmitter Clearance In The Synaptic Cleft
type: Pathway
data source: Provenance1
pathway component: REACT 245906.1
evidence: Evidence276
xref: RelationshipXref121
xref: UnificationXref3265
xref: UnificationXref3264
pathway order: PathwayStep267
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3349
type: UnificationXref
id: 6279995
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279995

UnificationXref3348
type: UnificationXref
id: REACT_254273
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254273.1

UnificationXref3347
type: UnificationXref
id: 6274071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274071

UnificationXref3346
type: UnificationXref
id: REACT_20379
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20379.2

UnificationXref3345
type: UnificationXref
id: 74126
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74126

UnificationXref3344
type: UnificationXref
id: REACT_2842
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2842.2

UnificationXref10919
type: UnificationXref
id: REACT_122294
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122294.1

UnificationXref3343
type: UnificationXref
id: 29804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29804

UnificationXref3342
type: UnificationXref
id: CHEBI:29103
db: ChEBI

UnificationXref3351
type: UnificationXref
id: Q652U9
db: UniProt

UnificationXref10926
type: UnificationXref
id: 6277008
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277008

UnificationXref3352
type: UnificationXref
id: 6274074
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274074

UnificationXref10927
type: UnificationXref
id: REACT_236693
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_236693.1

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

UnificationXref10928
type: UnificationXref
id: 194697
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194697

UnificationXref3350
type: UnificationXref
id: REACT_259338
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259338.1

UnificationXref10929
type: UnificationXref
id: REACT_121652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121652.1

UnificationXref10922
type: UnificationXref
id: REACT_121476
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121476.1

UnificationXref10923
type: UnificationXref
id: 2046049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046049

UnificationXref10924
type: UnificationXref
id: REACT_122430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122430.1

UnificationXref10925
type: UnificationXref
id: 6277006
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277006

UnificationXref10920
type: UnificationXref
id: CHEBI:51985
db: ChEBI

UnificationXref10921
type: UnificationXref
id: 2046062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046062

UnificationXref3358
type: UnificationXref
id: Q6K3T2
db: UniProt

UnificationXref3357
type: UnificationXref
id: 6274081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274081

UnificationXref3359
type: UnificationXref
id: 6274084
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274084

UnificationXref3354
type: UnificationXref
id: 6274077
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274077

Keratan sulfate/keratin metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 224443.2
pathway component: REACT 213002.2
evidence: Evidence498
xref: RelationshipXref323
xref: UnificationXref6349
xref: UnificationXref6348
pathway order: PathwayStep483
pathway order: PathwayStep486
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref3353
type: UnificationXref
id: Q7XUW4
db: UniProt

UnificationXref3356
type: UnificationXref
id: Q653P0
db: UniProt

UnificationXref3355
type: UnificationXref
id: 6274078
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274078

UnificationXref3360
type: UnificationXref
id: OS01T0718700-00
db: Ensembl

UnificationXref10939
type: UnificationXref
id: REACT_232727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232727.1

UnificationXref3361
type: UnificationXref
id: 6274087
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274087

UnificationXref3362
type: UnificationXref
id: 6274088
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274088

UnificationXref10937
type: UnificationXref
id: 6277003
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277003

UnificationXref3363
type: UnificationXref
id: OS04T0117500-00
db: Ensembl

UnificationXref10938
type: UnificationXref
id: 6277005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277005

UnificationXref10935
type: UnificationXref
id: 194653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194653

UnificationXref10936
type: UnificationXref
id: REACT_122696
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122696.1

UnificationXref10933
type: UnificationXref
id: 2046052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046052

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

UnificationXref10934
type: UnificationXref
id: REACT_125598
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125598.1

UnificationXref10931
type: UnificationXref
id: REACT_4717
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4717.2

UnificationXref10932
type: UnificationXref
id: CHEBI:63545
db: ChEBI

UnificationXref10930
type: UnificationXref
id: 113534
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113534

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

UnificationXref3367
type: UnificationXref
id: Q0JKV1
db: UniProt

UnificationXref3366
type: UnificationXref
id: 6274094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274094

UnificationXref3365
type: UnificationXref
id: Q5JM04
db: UniProt

UnificationXref3364
type: UnificationXref
id: 6274091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274091

UnificationXref3369
type: UnificationXref
id: E2DXN3
db: UniProt

UnificationXref3368
type: UnificationXref
id: 6274097
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274097

UnificationXref10900
type: UnificationXref
id: REACT_219433
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219433.2

UnificationXref3370
type: UnificationXref
id: 6274100
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274100

UnificationXref10901
type: UnificationXref
id: 6275984
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275984

UnificationXref10902
type: UnificationXref
id: REACT_212285
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212285.2

UnificationXref10903
type: UnificationXref
id: 6275803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275803

UnificationXref3373
type: UnificationXref
id: 6274104
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274104

UnificationXref10904
type: UnificationXref
id: REACT_255704
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_255704.1

UnificationXref3374
type: UnificationXref
id: 6274105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274105

UnificationXref10905
type: UnificationXref
id: 6280036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280036

UnificationXref3371
type: UnificationXref
id: OS01T0210700-01
db: Ensembl

UnificationXref10906
type: UnificationXref
id: REACT_215648
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215648.2

UnificationXref3372
type: UnificationXref
id: 6274103
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274103

UnificationXref10907
type: UnificationXref
id: 6280018
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280018

UnificationXref3376
type: UnificationXref
id: Q40648
db: UniProt

UnificationXref3375
type: UnificationXref
id: 6274106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274106

UnificationXref3378
type: UnificationXref
id: 6274110
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274110

UnificationXref10909
type: UnificationXref
id: 6279511
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279511

UnificationXref3377
type: UnificationXref
id: 6274109
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274109

UnificationXref10908
type: UnificationXref
id: REACT_227184
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227184.2

UnificationXref3379
type: UnificationXref
id: 6274111
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274111

UnificationXref10913
type: UnificationXref
id: REACT_121509
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121509.1

UnificationXref10914
type: UnificationXref
id: 162743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162743

UnificationXref3380
type: UnificationXref
id: 6274112
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274112

UnificationXref10911
type: UnificationXref
id: CHEBI:27432
db: ChEBI

UnificationXref3381
type: UnificationXref
id: 6274113
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274113

UnificationXref10912
type: UnificationXref
id: 2046056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046056

UnificationXref3382
type: UnificationXref
id: 6274115
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274115

UnificationXref10917
type: UnificationXref
id: REACT_119727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119727.1

UnificationXref3383
type: UnificationXref
id: REACT_243572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243572.1

UnificationXref10918
type: UnificationXref
id: 2046064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046064

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

UnificationXref3384
type: UnificationXref
id: 6279997
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279997

UnificationXref10915
type: UnificationXref
id: REACT_2982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2982.1

UnificationXref3385
type: UnificationXref
id: REACT_231270
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231270.1

UnificationXref10916
type: UnificationXref
id: 211579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211579

UnificationXref10910
type: UnificationXref
id: REACT_175943
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175943.3

UniProt:Q0GKV1
type: ProteinReference
xref: UnificationXref13788
organism: http://identifiers.org/taxonomy/4530

UnificationXref3394
type: UnificationXref
id: 6267938
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267938

UnificationXref3393
type: UnificationXref
id: B7EK64
db: UniProt

UnificationXref3396
type: UnificationXref
id: Q0DLD4
db: UniProt

UnificationXref3395
type: UnificationXref
id: 6267939
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267939

UnificationXref3390
type: UnificationXref
id: GO:0005778
db: GENE ONTOLOGY

UnificationXref3392
type: UnificationXref
id: 6267936
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267936

UnificationXref3391
type: UnificationXref
id: Q69M23
db: UniProt

UnificationXref3386
type: UnificationXref
id: 6279996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279996

UnificationXref3387
type: UnificationXref
id: REACT_233226
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233226.1

UnificationXref3388
type: UnificationXref
id: 6279392
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279392

UnificationXref3389
type: UnificationXref
id: REACT_204605
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204605.2

UniProt:A2ZXD6
type: ProteinReference
xref: UnificationXref18772
organism: http://identifiers.org/taxonomy/4530

UniProt:A2ZXD8
type: ProteinReference
xref: UnificationXref17743
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/8104944
type: PublicationXref
id: 8104944
author: Brown, WC
author: Campbell, JL
db: Pubmed
title: Interaction of proliferating cell nuclear antigen with yeast DNA polymerase delta.
source: J Biol Chem 268:21706-10
year: 1993

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref3399
type: UnificationXref
id: 6267941
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267941

UnificationXref3397
type: UnificationXref
id: 6267940
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267940

UnificationXref3398
type: UnificationXref
id: Q65X28
db: UniProt

UniProt:Q2QNN5
type: ProteinReference
xref: UnificationXref11501
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/16271386
type: PublicationXref
id: 16271386
author: Tomari, Y
author: Bartel, DP
author: Zamore, Phillip D
author: Shin, C
author: Matranga, C
db: Pubmed
title: Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
source: Cell 123:607-20
year: 2005

Mismatch Repair
type: Pathway
data source: Provenance1
pathway component: REACT 239557.1
pathway component: REACT 244706.1
evidence: Evidence1568
xref: UnificationXref16479
xref: UnificationXref16480
xref: RelationshipXref1411
pathway order: PathwayStep1551
pathway order: PathwayStep1545
display name: MMR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNM6
type: ProteinReference
xref: UnificationXref11499
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNM4
type: ProteinReference
xref: UnificationXref16274
organism: http://identifiers.org/taxonomy/4530

UniProt:A2ZXB3
type: ProteinReference
xref: UnificationXref10143
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNM1
type: ProteinReference
xref: UnificationXref1662
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

UniProt:Q2QNT8
type: ProteinReference
xref: UnificationXref16923
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNT9
type: ProteinReference
xref: UnificationXref16929
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/19603532
type: PublicationXref
id: 19603532
author: Dubourg, Christèle
author: Solomon, Benjamin D
author: Pineda-Alvarez, Daniel E
author: Bendavid, Claude
author: Zhou, Nan
author: Muenke, Maximilian
author: Ouspenskaia, Maia
author: Hehr, Ute
author: Lacbawan, Felicitas
author: El-Jaick, Kenia B
author: Smeets, Hubert J
author: David, Véronique
author: Bale, Sherri
author: Vélez, Jorge I
author: Odent, Sylvie
author: Roessler, Erich
author: Paulussen, Aimée
db: Pubmed
title: The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
source: Hum. Mutat. 30:E921-35
year: 2009

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

UniProt:Q2QNR9
type: ProteinReference
xref: UnificationXref13042
organism: http://identifiers.org/taxonomy/4530

UnificationXref10988
type: UnificationXref
id: 6277024
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277024

UnificationXref10989
type: UnificationXref
id: REACT_195746
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_195746.3

UniProt:Q2QNR8
type: ProteinReference
xref: UnificationXref13034
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2QNR7
type: ProteinReference
xref: UnificationXref13036
organism: http://identifiers.org/taxonomy/4530

UnificationXref10982
type: UnificationXref
id: REACT_123653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123653.1

UnificationXref10983
type: UnificationXref
id: 6277027
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277027

UnificationXref10980
type: UnificationXref
id: CHEBI:65139
db: ChEBI

UnificationXref10981
type: UnificationXref
id: 2066767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066767

UnificationXref10986
type: UnificationXref
id: 2066766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066766

UnificationXref10987
type: UnificationXref
id: REACT_121859
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121859.1

UniProt:Q2R030
type: ProteinReference
xref: UnificationXref11978
organism: http://identifiers.org/taxonomy/4530

UnificationXref10984
type: UnificationXref
id: REACT_195733
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_195733.3

UnificationXref10985
type: UnificationXref
id: CHEBI:65130
db: ChEBI

UnificationXref10999
type: UnificationXref
id: REACT_195731
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_195731.3

http://identifiers.org/pubmed/21413788
type: PublicationXref
id: 21413788
author: Dunaway-Mariano, Debra
author: Wu, Rui
author: Garland, Megan
author: Allen, Karen N
db: Pubmed
title: Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1
source: Biochemistry 50:3045-7
year: 2011

UnificationXref10991
type: UnificationXref
id: 2066762
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066762

UnificationXref10992
type: UnificationXref
id: REACT_124098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124098.1

UnificationXref10993
type: UnificationXref
id: 6277026
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277026

UnificationXref10994
type: UnificationXref
id: REACT_195748
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_195748.3

UnificationXref10995
type: UnificationXref
id: CHEBI:65132
db: ChEBI

UnificationXref10996
type: UnificationXref
id: 2066765
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066765

UnificationXref10997
type: UnificationXref
id: REACT_124023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124023.1

UnificationXref10998
type: UnificationXref
id: 6277029
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6277029

UnificationXref10990
type: UnificationXref
id: CHEBI:65131
db: ChEBI

UniProt:Q2R0H5
type: ProteinReference
xref: UnificationXref15508
organism: http://identifiers.org/taxonomy/4530

UniProt:Q2R0H4
type: ProteinReference
xref: UnificationXref15512
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K1R5
type: ProteinReference
xref: UnificationXref12540
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

UniProt:Q6K1Q6
type: ProteinReference
xref: UnificationXref18280
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

UniProt:Q6K1S5
type: ProteinReference
xref: UnificationXref7204
organism: http://identifiers.org/taxonomy/4530

UniProt:Q6K248
type: ProteinReference
xref: UnificationXref7964
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/10681536
type: PublicationXref
id: 10681536
author: Gaither, LA
author: Eide, DJ
db: Pubmed
title: Functional expression of the human hZIP2 zinc transporter
source: J Biol Chem 275:5560-4
year: 2000

http://identifiers.org/pubmed/18367721
type: PublicationXref
id: 18367721
author: Skinner, SJ
author: Deleault, KM
author: Whitfield, ML
author: Brooks, SA
author: Gross, RH
author: Townley-Tilson, WH
author: Emmons, J
db: Pubmed
title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
source: RNA 14:888-902
year: 2008

Stoichiometry8
type: Stoichiometry
physical entity: PhysicalEntity2
stoichiometric coefficient: 1.0

Stoichiometry7
type: Stoichiometry
physical entity: Complex2
stoichiometric coefficient: 1.0

Stoichiometry9
type: Stoichiometry
physical entity: Protein48
stoichiometric coefficient: 1.0

Stoichiometry2
type: Stoichiometry
physical entity: Protein1
stoichiometric coefficient: 1.0

Stoichiometry1
type: Stoichiometry
physical entity: SmallMolecule2
stoichiometric coefficient: 1.0

Stoichiometry4
type: Stoichiometry
physical entity: Protein2
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: SmallMolecule1
stoichiometric coefficient: 1.0

Stoichiometry6
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: Protein10
stoichiometric coefficient: 1.0

UniProt:Q6K215
type: ProteinReference
xref: UnificationXref5202
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

The citric acid (TCA) cycle and respiratory electron transport
type: Pathway
data source: Provenance1
pathway component: REACT 232410.1
pathway component: REACT 252601.1
evidence: Evidence1140
xref: RelationshipXref993
xref: UnificationXref12382
xref: UnificationXref12381
pathway order: PathwayStep1114
pathway order: PathwayStep1125
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UniProt:Q5JQW8
type: ProteinReference
xref: UnificationXref4969
organism: http://identifiers.org/taxonomy/4530

UniProt:A2ZXQ2
type: ProteinReference
xref: UnificationXref9244
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/6022858
type: PublicationXref
id: 6022858
author: Younathan, ES
author: Pynes, GD
db: Pubmed
title: Purification and some properties of inorganic pyrophosphatase from human erythrocytes
source: J Biol Chem 242:2119-23
year: 1967

http://identifiers.org/pubmed/2770297
type: PublicationXref
id: 2770297
author: Thomas, JL
author: Myers, RP
author: Strickler, RC
db: Pubmed
title: Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
source: J Steroid Biochem 33:209-17
year: 1989

UniProt:Q2R0E9
type: ProteinReference
xref: UnificationXref3911
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

UnificationXref3419
type: UnificationXref
id: 6267959
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267959

UnificationXref3418
type: UnificationXref
id: 6267958
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267958

UnificationXref3417
type: UnificationXref
id: 6267957
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267957

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

UnificationXref3416
type: UnificationXref
id: 6267956
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267956

UnificationXref3415
type: UnificationXref
id: 6267955
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267955

UnificationXref3414
type: UnificationXref
id: 6267954
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267954

UnificationXref3413
type: UnificationXref
id: 6267953
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267953

UnificationXref3412
type: UnificationXref
id: 6267952
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267952

UnificationXref3411
type: UnificationXref
id: 6267951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267951

UnificationXref3410
type: UnificationXref
id: 6267950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267950

UnificationXref3409
type: UnificationXref
id: 6267949
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267949

UnificationXref3406
type: UnificationXref
id: 6267946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267946

UnificationXref3405
type: UnificationXref
id: 6267945
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267945

UnificationXref3408
type: UnificationXref
id: 6267948
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267948

UnificationXref3407
type: UnificationXref
id: 6267947
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267947

UnificationXref3402
type: UnificationXref
id: B9FM21
db: UniProt

UnificationXref3401
type: UnificationXref
id: 6267942
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267942

UnificationXref3404
type: UnificationXref
id: 6267944
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267944

UnificationXref3403
type: UnificationXref
id: 6267943
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267943

UnificationXref3400
type: UnificationXref
id: Q0JFR5
db: UniProt

http://identifiers.org/pubmed/20042001
type: PublicationXref
id: 20042001
author: Wolf, George
db: Pubmed
title: Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance
source: Nutr. Rev. 68:67-70
year: 2010

UniProt:Q94LR9
type: ProteinReference
xref: UnificationXref9401
organism: http://identifiers.org/taxonomy/4530

UnificationXref10413
type: UnificationXref
id: REACT_250918
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250918.1

UnificationXref10412
type: UnificationXref
id: 6280010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280010

UnificationXref10415
type: UnificationXref
id: 1483256
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1483256

UnificationXref10414
type: UnificationXref
id: CHEBI:17517
db: ChEBI

UnificationXref10411
type: UnificationXref
id: REACT_235160
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235160.1

UnificationXref10410
type: UnificationXref
id: 6275048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275048

UnificationXref10417
type: UnificationXref
id: 6275327
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275327

UnificationXref10416
type: UnificationXref
id: REACT_124009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124009.1

UnificationXref10419
type: UnificationXref
id: 6275329
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275329

UnificationXref10418
type: UnificationXref
id: 6275328
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275328

UniProt:Q94LQ1
type: ProteinReference
xref: UnificationXref15750
organism: http://identifiers.org/taxonomy/4530

UnificationXref10404
type: UnificationXref
id: 6275044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275044

UnificationXref10403
type: UnificationXref
id: REACT_122617
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122617.1

UnificationXref10402
type: UnificationXref
id: 1498733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498733

UnificationXref10401
type: UnificationXref
id: CHEBI:28914
db: ChEBI

UnificationXref10400
type: UnificationXref
id: REACT_223915
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223915.2

UnificationXref10409
type: UnificationXref
id: REACT_123040
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123040.1

UnificationXref10408
type: UnificationXref
id: 1498737
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498737

UnificationXref10407
type: UnificationXref
id: CHEBI:62746
db: ChEBI

UnificationXref10406
type: UnificationXref
id: REACT_262159
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_262159.1

UnificationXref10405
type: UnificationXref
id: 6275046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275046

http://identifiers.org/pubmed/12949583
type: PublicationXref
id: 12949583
author: van den Bosch, M
author: Lowndes, NF
author: Bree, RT
db: Pubmed
title: The MRN complex: coordinating and mediating the response to broken chromosomes.
source: EMBO Rep 4:844-9
year: 2003

UniProt:P51823
type: ProteinReference
xref: UnificationXref182
organism: http://identifiers.org/taxonomy/4530

UnificationXref10438
type: UnificationXref
id: 1524042
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524042

UnificationXref10439
type: UnificationXref
id: REACT_121634
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121634.1

UnificationXref10430
type: UnificationXref
id: 6275334
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275334

UnificationXref10431
type: UnificationXref
id: 6275335
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275335

UnificationXref10432
type: UnificationXref
id: 6275336
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275336

UnificationXref10433
type: UnificationXref
id: 6275338
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275338

UnificationXref10434
type: UnificationXref
id: REACT_208515
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_208515.2

UnificationXref10435
type: UnificationXref
id: CHEBI:37393
db: ChEBI

UnificationXref10436
type: UnificationXref
id: 1524059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524059

UnificationXref10437
type: UnificationXref
id: REACT_121430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121430.1

http://identifiers.org/pubmed/12692040
type: PublicationXref
id: 12692040
author: Hirschhorn, JN
author: Chitkara, DK
author: Montgomery, RK
author: Grand, RJ
db: Pubmed
title: Changing genes; losing lactase
source: Gut 52:617-9
year: 2003

UnificationXref10429
type: UnificationXref
id: REACT_7747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7747.2

UnificationXref10427
type: UnificationXref
id: REACT_124717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124717.1

UnificationXref10428
type: UnificationXref
id: 159450
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159450

UnificationXref10421
type: UnificationXref
id: REACT_175207
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175207.3

UnificationXref10422
type: UnificationXref
id: 1524101
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524101

UnificationXref10420
type: UnificationXref
id: 6275331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275331

UnificationXref10425
type: UnificationXref
id: REACT_4926
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4926.1

UnificationXref10426
type: UnificationXref
id: 1524064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524064

UnificationXref10423
type: UnificationXref
id: REACT_124007
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124007.1

UnificationXref10424
type: UnificationXref
id: 110577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110577

UnificationXref10451
type: UnificationXref
id: 6275384
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275384

UnificationXref10450
type: UnificationXref
id: Q0DGM1
db: UniProt

UnificationXref10456
type: UnificationXref
id: REACT_224714
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224714.2

UnificationXref10457
type: UnificationXref
id: CHEBI:62747
db: ChEBI

UnificationXref10458
type: UnificationXref
id: 1498740
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498740

UnificationXref10459
type: UnificationXref
id: REACT_123762
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123762.1

UnificationXref10452
type: UnificationXref
id: 6275385
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275385

UnificationXref10453
type: UnificationXref
id: 6275387
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275387

UnificationXref10454
type: UnificationXref
id: REACT_205113
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205113.2

UnificationXref10455
type: UnificationXref
id: 6280022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280022

HEXA,B cleaves the terminal GalNAc from DS
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence508
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.52
xref: UnificationXref6406
xref: UnificationXref6405
left: SmallMolecule335
left: SmallMolecule355
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule345
right: SmallMolecule356

UnificationXref10440
type: UnificationXref
id: Q7XC53
db: UniProt

Oxidative cleavage of beta-carotene to all-trans-retinal
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence524
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.99.36
xref: UnificationXref6447
xref: UnificationXref6446
participant stoichiometry: Stoichiometry817
left: SmallMolecule293
left: SmallMolecule357
display name: BCMO1:Fe2+ cleaves betaC to atRAL
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule358

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence504
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.31
xref: UnificationXref6387
xref: UnificationXref6388
left: SmallMolecule335
left: SmallMolecule352
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule336
right: SmallMolecule353

Beta-galactosidase (GLB1) can cleave galactose from the linker chain
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence505
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.23
xref: UnificationXref6394
xref: UnificationXref6393
participant stoichiometry: Stoichiometry816
participant stoichiometry: Stoichiometry815
left: SmallMolecule335
left: SmallMolecule353
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule342
right: SmallMolecule354

cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence529
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6545
xref: UnificationXref6546
left: Sodium
left: Calcium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Sodium
right: Calcium

NCKX1 removes Ca2+ from the rod outer segment
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence530
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6547
xref: UnificationXref6548
participant stoichiometry: Stoichiometry826
participant stoichiometry: Stoichiometry827
left: Sodium
left: Calcium
left: Potassium
display name: NCKX1 exchanges Na+ for Ca2+/K+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Sodium
right: Calcium
right: Potassium

http://identifiers.org/pubmed/3130248
type: PublicationXref
id: 3130248
author: Shanina, NA
author: Gelfand, VI
author: Chernyak, VY
author: Vaisberg, EA
author: Kuznetsov, SA
author: Magretova, NN
db: Pubmed
title: The quaternary structure of bovine brain kinesin
source: EMBO J 7:353-6
year: 1988

BCO2:Fe2+ cleaves betaC to APO10al and bION
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence525
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11
xref: UnificationXref6464
xref: UnificationXref6463
left: SmallMolecule359
left: SmallMolecule360
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule361
right: SmallMolecule362

Retinoid isomerohydrolase isomero-hydrolyses retinyl esters to 11-cis-retinol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence527
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6499
xref: UnificationXref6500
left: Water
left: SmallMolecule364
display name: RPE65 isomero-hydrolyses atREs to 11cROL
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule374
right: SmallMolecule369

PPi
type: SmallMoleculeReference
name: PPi [ChEBI:29888]
xref: UnificationXref6298

UnificationXref10449
type: UnificationXref
id: 6275382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275382

UnificationXref10447
type: UnificationXref
id: 6275379
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275379

UnificationXref10448
type: UnificationXref
id: Q5JNL3
db: UniProt

UnificationXref10445
type: UnificationXref
id: 6275376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275376

UnificationXref10446
type: UnificationXref
id: Q0DEH7
db: UniProt

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence503
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.50
xref: UnificationXref6382
xref: UnificationXref6383
left: SmallMolecule335
left: SmallMolecule351
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule352
right: SmallMolecule338

UnificationXref10443
type: UnificationXref
id: 6275373
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275373

HGSNAT acetylates another terminal N-glucosamine in heparan
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence502
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.78
xref: UnificationXref6378
xref: UnificationXref6377
left: SmallMolecule350
left: Acetyl coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule351
right: coenzyme A

UnificationXref10444
type: UnificationXref
id: Q5W666
db: UniProt

UnificationXref10441
type: UnificationXref
id: 6275371
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275371

UnificationXref10442
type: UnificationXref
id: Q108Y1
db: UniProt

cGMP binds CNG channel to form cGMP:CNG channel
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence533
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6554
xref: UnificationXref6553
left: SmallMolecule375
left: Complex307
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex306

Calmodulin:Ca2+ lowers CNG channel sensitivity to cGMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence534
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6557
xref: UnificationXref6558
left: Complex307
left: Complex308
display name: CALM1:Ca2+ binds CNG channel
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex309

Decreased cGMP closes cation channels
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence531
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6549
xref: UnificationXref6550
left: Complex306
display name: cGMP dissociates from CNG channels
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule375
right: Complex307

http://identifiers.org/pubmed/15585754
type: PublicationXref
id: 15585754
author: Hicklin, DJ
author: Ellis, LM
db: Pubmed
title: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
source: J Clin Oncol 23:1011-27
year: 2005

UnificationXref14950
type: UnificationXref
id: 6266528
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266528

UnificationXref14958
type: UnificationXref
id: 6266546
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266546

UnificationXref14957
type: UnificationXref
id: 6266544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266544

UnificationXref14956
type: UnificationXref
id: 6266543
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266543

UnificationXref14955
type: UnificationXref
id: 6266541
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266541

UnificationXref14954
type: UnificationXref
id: 6266538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266538

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

UnificationXref14953
type: UnificationXref
id: 6266536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266536

UnificationXref14952
type: UnificationXref
id: 6266533
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266533

UnificationXref14951
type: UnificationXref
id: 6266531
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266531

Digestion of lactose to yield glucose and galactose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence547
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.108
xref: UnificationXref6681
xref: UnificationXref6682
left: SmallMolecule380
left: SmallMolecule277
display name: lactose + H2O => D-glucose + D-galactose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule381
right: SmallMolecule184

Digestion of maltose by sucrase-isomaltase to yield glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence546
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.20
xref: UnificationXref6624
xref: UnificationXref6623
participant stoichiometry: Stoichiometry839
left: SmallMolecule277
left: SmallMolecule378
display name: maltose + H2O => 2 D-glucose (sucrase-isomaltase)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184

Digestion of maltose by maltase-glucoamylase to yield glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence545
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.20
xref: UnificationXref6621
xref: UnificationXref6622
participant stoichiometry: Stoichiometry838
left: SmallMolecule277
left: SmallMolecule378
display name: maltose + H2O => 2 D-glucose (maltase-glucoamylase)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184

Digestion of maltotriose by sucrase-isomaltase to yield maltose and glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence544
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.20
xref: UnificationXref6620
xref: UnificationXref6619
left: SmallMolecule277
left: SmallMolecule379
display name: maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184
right: SmallMolecule378

Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence543
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.20
xref: UnificationXref6618
xref: UnificationXref6617
left: SmallMolecule277
left: SmallMolecule379
display name: maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184
right: SmallMolecule378

Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence542
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.20
xref: UnificationXref6613
xref: UnificationXref6612
left: SmallMolecule377
left: SmallMolecule277
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184
right: SmallMolecule378
right: SmallMolecule379

UnificationXref14959
type: UnificationXref
id: REACT_263008
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263008.1

2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence540
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref6590
xref: UnificationXref6589
left: proton
left: SmallMolecule235
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule376

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

Digestion of sucrose to yield glucose and fructose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence548
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.26
EC number: 3.2.1.48
xref: UnificationXref6690
xref: UnificationXref6689
left: SmallMolecule382
left: SmallMolecule277
display name: sucrose + H2O => glucose + fructose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule383
right: SmallMolecule184

http://identifiers.org/pubmed/18772128
type: PublicationXref
id: 18772128
author: Riekhof, WR
author: Voelker, DR
author: Gijon, MA
author: Zarini, S
author: Murphy, RC
db: Pubmed
title: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
source: J Biol Chem 283:30235-45
year: 2008

Digestion of trehalose to yield glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence549
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.28
xref: UnificationXref6698
xref: UnificationXref6697
participant stoichiometry: Stoichiometry841
left: SmallMolecule277
left: SmallMolecule384
display name: trehalose + H2O => 2 D-glucose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule184

Glucose 6-phosphate is isomerized to form fructose-6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence551
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.9
xref: UnificationXref6718
xref: UnificationXref6719
left: SmallMolecule183
display name: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule385

Dephosphorylation of phosphoPFKFB1 by PP2A complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence552
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.4
xref: UnificationXref6770
xref: UnificationXref6771
participant stoichiometry: Stoichiometry844
participant stoichiometry: Stoichiometry845
left: Complex317
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: Complex318

http://identifiers.org/pubmed/10393322
type: PublicationXref
id: 10393322
author: Yoshioka, S
author: Ishida, N
author: Takeuchi, M
author: Chiba, Y
author: Kawakita, M
db: Pubmed
title: Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter
source: J Biochem 126:68-77
year: 1999

UnificationXref14945
type: UnificationXref
id: 6266516
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266516

UnificationXref14944
type: UnificationXref
id: 6266513
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266513

UnificationXref14947
type: UnificationXref
id: 6266521
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266521

UnificationXref14946
type: UnificationXref
id: 6266518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266518

UnificationXref14941
type: UnificationXref
id: 6266505
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266505

UnificationXref14940
type: UnificationXref
id: 6266503
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266503

UnificationXref14943
type: UnificationXref
id: 6266511
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266511

UnificationXref14942
type: UnificationXref
id: 6266508
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266508

1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence558
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.2.3
xref: UnificationXref6943
xref: UnificationXref6942
left: SmallMolecule390
left: SmallMolecule6
display name: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule391
right: SmallMolecule5

Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence557
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.12
xref: UnificationXref6924
xref: UnificationXref6923
left: SmallMolecule3
left: SmallMolecule389
left: DPN
display name: D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule390

UnificationXref14949
type: UnificationXref
id: 6266526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266526

D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence554
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.11
xref: UnificationXref6839
xref: UnificationXref6838
left: SmallMolecule5
left: SmallMolecule385
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule387

UnificationXref14948
type: UnificationXref
id: 6266523
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266523

Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence553
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.105
xref: UnificationXref6793
xref: UnificationXref6792
left: SmallMolecule5
left: SmallMolecule385
display name: D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule386

dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence556
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.1
xref: UnificationXref6887
xref: UnificationXref6888
left: SmallMolecule388
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule389

D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence555
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.2.13
xref: UnificationXref6878
xref: UnificationXref6877
left: SmallMolecule387
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule388
right: SmallMolecule389

3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence559
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.2.1
xref: UnificationXref6953
xref: UnificationXref6954
left: SmallMolecule391
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule393

Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence563
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.37
xref: UnificationXref7034
xref: UnificationXref7033
left: H+
left: SmallMolecule395
left: NADH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule146
right: DPN

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence564
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.37
xref: UnificationXref7042
xref: UnificationXref7041
left: SmallMolecule144
left: DPN
display name: malate + NAD+ <=> oxaloacetate + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule329

2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence560
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.11
xref: UnificationXref6964
xref: UnificationXref6965
left: SmallMolecule393
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule394
right: Water

phosphoenolpyruvate + ADP => pyruvate + ATP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence561
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.40
xref: UnificationXref7006
xref: UnificationXref7005
left: SmallMolecule394
left: SmallMolecule6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule332
right: SmallMolecule5

UnificationXref14971
type: UnificationXref
id: REACT_230150
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230150.1

UnificationXref14972
type: UnificationXref
id: 6279821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279821

UnificationXref14970
type: UnificationXref
id: 6266566
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266566

UnificationXref14976
type: UnificationXref
id: CHEBI:41774
db: ChEBI

UnificationXref14975
type: UnificationXref
id: REACT_252234
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252234.1

UnificationXref14974
type: UnificationXref
id: 6279518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279518

UnificationXref14973
type: UnificationXref
id: REACT_229524
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229524.1

UnificationXref14979
type: UnificationXref
id: CHEBI:63825
db: ChEBI

UnificationXref14978
type: UnificationXref
id: REACT_7485
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7485.2

UnificationXref14977
type: UnificationXref
id: 159154
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159154

phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence568
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7083
xref: UnificationXref7084
left: SmallMolecule397
left: SmallMolecule194
display name: Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule394
right: SmallMolecule398

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence567
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.1
xref: UnificationXref7070
xref: UnificationXref7071
left: SmallMolecule235
left: SmallMolecule170
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule329

UniProt:A2ZXX3
type: ProteinReference
xref: UnificationXref14164
organism: http://identifiers.org/taxonomy/4530

malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence566
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7063
xref: UnificationXref7062
left: SmallMolecule235
left: SmallMolecule146
display name: Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxoglutaric acid
right: SmallMolecule144

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence565
conversion direction: LEFT_TO_RIGHT
EC number: 2.6.1.1
xref: UnificationXref7057
xref: UnificationXref7058
left: SmallMolecule395
left: L-Glutaminic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxoglutaric acid
right: SmallMolecule396

Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence569
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.11
xref: UnificationXref7085
xref: UnificationXref7086
left: SmallMolecule394
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule393

2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence570
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.2.1
xref: UnificationXref7087
xref: UnificationXref7088
left: SmallMolecule393
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule391

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence571
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.2.3
xref: UnificationXref7090
xref: UnificationXref7089
left: SmallMolecule391
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule390
right: SmallMolecule6

1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence572
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.12
xref: UnificationXref7091
xref: UnificationXref7092
left: NADH
left: proton
left: SmallMolecule390
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule389
right: DPN

D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence573
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.1
xref: UnificationXref7094
xref: UnificationXref7093
left: SmallMolecule389
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule388

dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence574
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.2.13
xref: UnificationXref7095
xref: UnificationXref7096
left: SmallMolecule388
left: SmallMolecule389
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule387

D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence575
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.11
xref: UnificationXref7116
xref: UnificationXref7115
left: Water
left: SmallMolecule387
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule385

http://identifiers.org/pubmed/23604073
type: PublicationXref
id: 23604073
author: Ablasser, A
author: Hopfner, KP
author: Deimling, Tobias
author: Hornung, V
author: Cavlar, Taner
db: Pubmed
title: Species-specific detection of the antiviral small-molecule compound CMA by STING
source: EMBO J. 32:1440-50
year: 2013

UnificationXref14960
type: UnificationXref
id: 6279820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279820

UnificationXref14961
type: UnificationXref
id: REACT_238087
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238087.1

UnificationXref14963
type: UnificationXref
id: REACT_232092
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232092.1

UnificationXref14962
type: UnificationXref
id: 6266564
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266564

UnificationXref14965
type: UnificationXref
id: 216621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216621

UnificationXref14964
type: UnificationXref
id: CHEBI:37248
db: ChEBI

UnificationXref14967
type: UnificationXref
id: CHEBI:63904
db: ChEBI

UnificationXref14966
type: UnificationXref
id: REACT_13856
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13856.2

UnificationXref14969
type: UnificationXref
id: REACT_14525
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14525.1

UnificationXref14968
type: UnificationXref
id: 216612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216612

UniProt:A2ZXW2
type: ProteinReference
xref: UnificationXref13563
organism: http://identifiers.org/taxonomy/4530

D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence577
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.9
xref: UnificationXref7120
xref: UnificationXref7121
left: SmallMolecule385
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule183

UniProt:P49030
type: ProteinReference
xref: UnificationXref21529
organism: http://identifiers.org/taxonomy/4530

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence576
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.46
xref: UnificationXref7119
xref: UnificationXref7118
left: Water
left: SmallMolecule386
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule385

UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence580
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.9
xref: UnificationXref7150
xref: UnificationXref7149
left: SmallMolecule399
left: SmallMolecule400
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule270

alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence579
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.2.2
xref: UnificationXref7138
xref: UnificationXref7137
left: SmallMolecule183
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule399

UnificationXref14994
type: UnificationXref
id: REACT_13855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13855.2

UnificationXref14993
type: UnificationXref
id: 217320
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217320

UnificationXref14992
type: UnificationXref
id: CHEBI:63828
db: ChEBI

UnificationXref14991
type: UnificationXref
id: REACT_14663
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14663.2

UnificationXref14990
type: UnificationXref
id: 217315
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217315

poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence588
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7273
xref: UnificationXref7272
left: SmallMolecule3
left: Complex373
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule399
right: Complex374

glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence587
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7243
xref: UnificationXref7242
left: SmallMolecule3
left: Complex370
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule399
right: Complex371

glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence586
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7229
xref: UnificationXref7230
left: SmallMolecule3
left: Complex366
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule399
right: Complex367

PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence585
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7180
xref: UnificationXref7179
participant stoichiometry: Stoichiometry910
left: Complex365
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7
right: Complex364

PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence584
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7176
xref: UnificationXref7175
participant stoichiometry: Stoichiometry907
left: SmallMolecule7
left: Complex364
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex365

PGYB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence583
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7167
xref: UnificationXref7166
participant stoichiometry: Stoichiometry905
left: Complex363
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7
right: Complex362

PGYB dimer, b form + 2 AMP <=> PGYB b dimer:AMP complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence582
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7165
xref: UnificationXref7164
participant stoichiometry: Stoichiometry902
left: SmallMolecule7
left: Complex362
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex363

D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence593
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.2.13
xref: UnificationXref7293
xref: UnificationXref7292
left: SmallMolecule401
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule388
right: SmallMolecule402

poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence589
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7279
xref: UnificationXref7278
left: SmallMolecule3
left: Complex375
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex376
right: SmallMolecule399

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence590
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.2.2
xref: UnificationXref7281
xref: UnificationXref7280
left: SmallMolecule399
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule183

UnificationXref14999
type: UnificationXref
id: REACT_224475
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224475.2

UnificationXref14997
type: UnificationXref
id: 6266853
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266853

UnificationXref14998
type: UnificationXref
id: 6266855
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266855

UnificationXref14995
type: UnificationXref
id: Q7XWZ4
db: UniProt

UnificationXref14996
type: UnificationXref
id: 6266852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266852

UnificationXref14981
type: UnificationXref
id: REACT_14315
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14315.2

UnificationXref14980
type: UnificationXref
id: 217269
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217269

UnificationXref14983
type: UnificationXref
id: REACT_13844
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13844.1

UnificationXref14982
type: UnificationXref
id: 217259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217259

D-ribulose 5-phosphate <=> xylulose 5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence601
conversion direction: LEFT_TO_RIGHT
EC number: 5.1.3.1
xref: UnificationXref7376
xref: UnificationXref7377
left: SmallMolecule406
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule408

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence600
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.44
xref: UnificationXref7369
xref: UnificationXref7368
left: NADP+
left: SmallMolecule405
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: proton
right: NADPH
right: SmallMolecule406

ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence603
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.1
xref: UnificationXref7392
xref: UnificationXref7393
left: SmallMolecule408
left: SmallMolecule409
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule389
right: SmallMolecule410

xylulose 5-phosphate <=> D-ribulose 5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence602
conversion direction: LEFT_TO_RIGHT
EC number: 5.1.3.1
xref: UnificationXref7378
xref: UnificationXref7379
left: SmallMolecule408
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule406

UDP-galactose <=> UDP-glucose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence596
conversion direction: LEFT_TO_RIGHT
EC number: 5.1.3.2
xref: UnificationXref7317
xref: UnificationXref7318
left: SmallMolecule255
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule270

http://identifiers.org/pubmed/8386433
type: PublicationXref
id: 8386433
author: Horrobin, DF
db: Pubmed
title: Fatty acid metabolism in health and disease: the role of delta-6-desaturase
source: Am J Clin Nutr 57:732S-736S; discussion 736S-737S
year: 1993

D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence595
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.12
xref: UnificationXref7302
xref: UnificationXref7301
left: SmallMolecule403
left: SmallMolecule270
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule399
right: SmallMolecule255

D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence599
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.31
xref: UnificationXref7354
xref: UnificationXref7355
left: Water
left: SmallMolecule404
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule405

alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence598
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.49
xref: UnificationXref7341
xref: UnificationXref7340
left: NADP+
left: SmallMolecule183
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule404
right: NADPH

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence604
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.1
xref: UnificationXref7394
xref: UnificationXref7395
left: SmallMolecule389
left: SmallMolecule410
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule408
right: SmallMolecule409

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence605
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.2
xref: UnificationXref7405
xref: UnificationXref7404
left: SmallMolecule389
left: SmallMolecule410
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule412
right: SmallMolecule385

UnificationXref14988
type: UnificationXref
id: REACT_210902
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210902.2

UnificationXref14989
type: UnificationXref
id: CHEBI:50673
db: ChEBI

UnificationXref14984
type: UnificationXref
id: Q69NI6
db: UniProt

UnificationXref14985
type: UnificationXref
id: 6266846
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266846

UnificationXref14986
type: UnificationXref
id: 6266847
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266847

UnificationXref14987
type: UnificationXref
id: 6266849
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266849

D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence606
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.2
xref: UnificationXref7407
xref: UnificationXref7406
left: SmallMolecule412
left: SmallMolecule385
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule389
right: SmallMolecule410

ribose 5-phosphate <=> D-ribulose 5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence610
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.6
xref: UnificationXref7422
xref: UnificationXref7421
left: SmallMolecule409
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule406

D-ribulose 5-phosphate <=> ribose 5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence609
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.1.6
xref: UnificationXref7419
xref: UnificationXref7420
left: SmallMolecule406
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule409

D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence608
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.1
xref: UnificationXref7411
xref: UnificationXref7410
left: SmallMolecule389
left: SmallMolecule385
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule408
right: SmallMolecule412

xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence607
conversion direction: LEFT_TO_RIGHT
EC number: 2.2.1.1
xref: UnificationXref7408
xref: UnificationXref7409
left: SmallMolecule408
left: SmallMolecule412
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule389
right: SmallMolecule385

Reduction of semidehydroascorbate to ascorbate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence619
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7543
xref: UnificationXref7544
left: SmallMolecule419
left: Complex386
display name: CYB5A:heme reduces SDA to VitC
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule417
right: Complex387

ascorbate [extracellular] + 2 Na+ [extracellular] => ascorbate [cytosol] + 2 Na+ [cytosol]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence618
conversion direction: LEFT_TO_RIGHT
name: SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol
xref: UnificationXref7516
xref: UnificationXref7517
participant stoichiometry: Stoichiometry941
participant stoichiometry: Stoichiometry942
left: SmallMolecule416
left: Sodium
display name: Ascorbate transport across the plasma membrane
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule417
right: Sodium

addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence613
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.6.1
xref: UnificationXref7441
xref: UnificationXref7442
left: SmallMolecule409
left: SmallMolecule5
display name: D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule414
right: SmallMolecule7

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence612
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.6.1
xref: UnificationXref7439
xref: UnificationXref7438
left: SmallMolecule409
left: SmallMolecule413
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule414
right: SmallMolecule415

ferric CYB5A + NADH + H+ => ferrous CYPB5A + NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence620
conversion direction: LEFT_TO_RIGHT
EC number: 1.6.2.2
xref: UnificationXref7558
xref: UnificationXref7557
left: NADH
left: proton
left: Complex387
display name: CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex386
right: DPN

UniProt:Q94LV4
type: ProteinReference
xref: UnificationXref13419
organism: http://identifiers.org/taxonomy/4530

2xTPK1:Mg2+ phosphorylates THMN
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence623
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.6.2
xref: UnificationXref7598
xref: UnificationXref7599
left: SmallMolecule425
left: SmallMolecule5
display name: Thiamin is pyrophosphorylated
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7
right: SmallMolecule411

dehydroascorbate (DHA) + 2 glutathione (GSH) => ascorbate + oxidized glutathione (GSSG)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence621
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.5.1
xref: UnificationXref7579
xref: UnificationXref7580
participant stoichiometry: Stoichiometry949
left: SmallMolecule422
left: SmallMolecule423
display name: 2xGSTOs reduce DHvitC to VitC
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule417
right: SmallMolecule424

FMN can be hydrolyzed back to riboflavin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence626
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.2
xref: UnificationXref7625
xref: UnificationXref7626
left: SmallMolecule427
left: Water
display name: 2xTRAP hydrolyzes FMN to RIB
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule428
right: SmallMolecule3

FAD can be hydrolyzed back to FMN
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence625
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.1.9
xref: UnificationXref7611
xref: UnificationXref7610
left: SmallMolecule426
left: Water
display name: 2xENPP1 hydrolyzes FAD to FMN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule427
right: SmallMolecule7

Phosphopantothenoylcysteine is decarboxylated
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence629
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.36
xref: UnificationXref7652
xref: UnificationXref7651
left: SmallMolecule430
display name: 3xPPCDC:3FMN decarboxylates PPC
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule431

Condensation of phosphopantothenate with cysteine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence628
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.5
xref: UnificationXref7643
xref: UnificationXref7644
left: SmallMolecule429
left: SmallMolecule176
left: SmallMolecule5
display name: 2xPPCS ligates PPanK with Cys
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule430

Phosphorylation of dephospho-CoA to produce CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence631
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.24
xref: UnificationXref7666
xref: UnificationXref7665
left: SmallMolecule5
left: SmallMolecule432
display name: COASY phosphorylates DP-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: coenzyme A

COASY transfers an adenylyl group from ATP to PPANT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence630
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.3
xref: UnificationXref7664
xref: UnificationXref7663
left: SmallMolecule5
left: SmallMolecule431
display name: Adenylation of phosphopantetheine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule432

PLP results from phosphorylation of pyridoxal
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence635
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.35
xref: UnificationXref7694
xref: UnificationXref7693
left: SmallMolecule5
left: SmallMolecule434
display name: 2xPDXK:2xZn2+ phosphorylates PXL
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Pyridoxal 5'-phosphate
right: SmallMolecule6

http://identifiers.org/pubmed/22118461
type: PublicationXref
id: 22118461
author: Desai, Arshad
author: Hombauer, Hans
author: Smith, Catherine E
author: Campbell, Christopher S
author: Kolodner, Richard D
db: Pubmed
title: Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
source: Cell 147:1040-53
year: 2011

SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence632
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7679
xref: UnificationXref7678
left: coenzyme A
display name: CoA transport across the inner mitochondrial membrane
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule433

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

UniProt:A2ZZ12
type: ProteinReference
xref: UnificationXref1104
organism: http://identifiers.org/taxonomy/4530

Conversion of palmitic acid to very long chain fatty acyl-CoAs
type: Pathway
data source: Provenance1
pathway component: lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4]
pathway component: palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2]
pathway component: arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
pathway component: trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
pathway component: 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
pathway component: arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
pathway component: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1]
pathway component: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3]
pathway component: arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
pathway component: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5]
pathway component: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6]
pathway component: palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1]
evidence: Evidence760
xref: RelationshipXref597
xref: UnificationXref8783
xref: UnificationXref8784
pathway order: PathwayStep744
pathway order: PathwayStep743
pathway order: PathwayStep742
pathway order: PathwayStep741
pathway order: PathwayStep740
pathway order: PathwayStep738
pathway order: PathwayStep739
pathway order: PathwayStep745
pathway order: PathwayStep736
pathway order: PathwayStep737
pathway order: PathwayStep746
pathway order: PathwayStep747
display name: Synthesis of very long-chain fatty acyl-CoAs
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

O2/CO2 exchange in erythrocytes
type: Pathway
data source: Provenance1
pathway component: REACT 211190.2
pathway component: REACT 222442.2
evidence: Evidence1425
xref: RelationshipXref154
xref: UnificationXref15647
xref: UnificationXref15646
pathway order: PathwayStep1410
pathway order: PathwayStep1406
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

http://identifiers.org/pubmed/11130078
type: PublicationXref
id: 11130078
author: Sato, S
author: Takeda, K
author: Wagner, H
author: Sanjo, H
author: Takeuchi, O
author: Hoshino, K
author: Matsumoto, M
author: Kaisho, T
author: Kawai, T
author: Hemmi, H
author: Akira, S
db: Pubmed
title: A Toll-like receptor recognizes bacterial DNA
source: Nature 408:740-5
year: 2000

ABCC1 transports cytosolic Cbl to extracellular region
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence640
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.3.33
xref: UnificationXref7737
xref: UnificationXref7736
left: Water
left: SmallMolecule5
left: SmallMolecule443
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule444

HLCS biotinylates MCCC1:MCCC2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence642
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7758
xref: UnificationXref7759
participant stoichiometry: Stoichiometry965
participant stoichiometry: Stoichiometry966
participant stoichiometry: Stoichiometry972
participant stoichiometry: Stoichiometry971
left: SmallMolecule5
left: Complex399
left: SmallMolecule445
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex400
right: SmallMolecule340
right: SmallMolecule7

Cytoslic carboxylases translocate to mitochondrial matrix
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence643
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7766
xref: UnificationXref7767
left: Complex400
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex401

A phospho-ribosyl group is added to quinolinate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence645
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.19
xref: UnificationXref7779
xref: UnificationXref7778
left: proton
left: SmallMolecule414
left: SmallMolecule446
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule447
right: SmallMolecule340

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence646
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.1
xref: UnificationXref7798
xref: UnificationXref7797
left: SmallMolecule448
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule449
right: SmallMolecule450

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence647
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.1
xref: UnificationXref7807
xref: UnificationXref7806
left: SmallMolecule447
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule452

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence648
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.1
xref: UnificationXref7813
xref: UnificationXref7814
left: SmallMolecule447
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule452

2xPDXK:2xZn2+ phosphorylates PXA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence636
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.35
xref: UnificationXref7701
xref: UnificationXref7702
left: SmallMolecule5
left: SmallMolecule435
display name: Pyridoxamine is phosphorylated
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule436
right: SmallMolecule6

2xPDKX:2xZn2+ phosphorylates PDX
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence637
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.35
xref: UnificationXref7710
xref: UnificationXref7709
left: SmallMolecule437
left: SmallMolecule5
display name: Pyridoxine is phosphorylated
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule438
right: SmallMolecule6

AOX1 oxidises PXL to PDXate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence638
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.3.1
xref: UnificationXref7727
xref: UnificationXref7728
left: Water
left: SmallMolecule293
left: SmallMolecule434
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule439
right: SmallMolecule440

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

UniProt:Q6EX42
type: ProteinReference
xref: UnificationXref10747
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1972
type: Stoichiometry
physical entity: SmallMolecule554
stoichiometric coefficient: 1.0

Stoichiometry1973
type: Stoichiometry
physical entity: Protein6423
stoichiometric coefficient: 1.0

Stoichiometry1970
type: Stoichiometry
physical entity: Protein6421
stoichiometric coefficient: 2.0

Stoichiometry1971
type: Stoichiometry
physical entity: Complex864
stoichiometric coefficient: 6.0

Stoichiometry1976
type: Stoichiometry
physical entity: Protein6424
stoichiometric coefficient: 1.0

Stoichiometry1977
type: Stoichiometry
physical entity: Protein6424
stoichiometric coefficient: 1.0

Stoichiometry1974
type: Stoichiometry
physical entity: Complex866
stoichiometric coefficient: 1.0

Stoichiometry1975
type: Stoichiometry
physical entity: SmallMolecule1287
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

Stoichiometry1978
type: Stoichiometry
physical entity: SmallMolecule1288
stoichiometric coefficient: 1.0

carboxylic acid [ChEBI:33575]
type: SmallMoleculeReference
name: acidos carboxilicos
name: acide carboxylique
name: acido carboxilico
name: Carbonsaeure
name: RC(=O)OH
name: acides carboxyliques
name: Carbonsaeuren
name: carboxylic acid
name: Karbonsaeure
xref: UnificationXref11835

Stoichiometry1979
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry1980
type: Stoichiometry
physical entity: Protein6428
stoichiometric coefficient: 2.0

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction709
pathway component: Gq alpha activates Phospholipase C beta
pathway component: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
evidence: Evidence1088
xref: UnificationXref11974
xref: UnificationXref11975
pathway order: PathwayStep1071
pathway order: PathwayStep1073
pathway order: PathwayStep1072
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1960
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 2.0

Stoichiometry1961
type: Stoichiometry
physical entity: Protein6392
stoichiometric coefficient: 1.0

Stoichiometry1962
type: Stoichiometry
physical entity: SmallMolecule876
stoichiometric coefficient: 1.0

Stoichiometry1963
type: Stoichiometry
physical entity: Complex859
stoichiometric coefficient: 4.0

Stoichiometry1964
type: Stoichiometry
physical entity: Protein6393
stoichiometric coefficient: 4.0

Stoichiometry1965
type: Stoichiometry
physical entity: SmallMolecule1286
stoichiometric coefficient: 2.0

Stoichiometry1966
type: Stoichiometry
physical entity: SmallMolecule554
stoichiometric coefficient: 1.0

Stoichiometry1967
type: Stoichiometry
physical entity: Protein6414
stoichiometric coefficient: 1.0

Stoichiometry1968
type: Stoichiometry
physical entity: Complex862
stoichiometric coefficient: 2.0

Stoichiometry1969
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/9305837
type: PublicationXref
id: 9305837
author: Mäder, A W
author: Luger, K
author: Richmond, R K
author: Sargent, D F
author: Richmond, T J
db: Pubmed
title: Crystal structure of the nucleosome core particle at 2.8 A resolution
source: Nature 389:251-60
year: 1997

Stoichiometry1998
type: Stoichiometry
physical entity: Protein4380
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/8399223
type: PublicationXref
id: 8399223
author: Tanhauser, SM
author: Chen, X
author: Silverman, DN
author: Laipis, PJ
author: Kresge, AJ
author: Tu, C
db: Pubmed
title: Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III
source: Biochemistry 32:10757-62
year: 1993

Stoichiometry1999
type: Stoichiometry
physical entity: Protein6449
stoichiometric coefficient: 3.0

Stoichiometry1996
type: Stoichiometry
physical entity: PhysicalEntity218
stoichiometric coefficient: 1.0

Stoichiometry1997
type: Stoichiometry
physical entity: Protein3419
stoichiometric coefficient: 1.0

Stoichiometry1994
type: Stoichiometry
physical entity: Protein3419
stoichiometric coefficient: 1.0

Stoichiometry1995
type: Stoichiometry
physical entity: Protein6450
stoichiometric coefficient: 1.0

Stoichiometry1992
type: Stoichiometry
physical entity: Protein6450
stoichiometric coefficient: 1.0

Stoichiometry1993
type: Stoichiometry
physical entity: Protein6449
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

Stoichiometry1985
type: Stoichiometry
physical entity: Protein4380
stoichiometric coefficient: 2.0

Stoichiometry1986
type: Stoichiometry
physical entity: Protein6446
stoichiometric coefficient: 2.0

Stoichiometry1987
type: Stoichiometry
physical entity: Complex873
stoichiometric coefficient: 1.0

Stoichiometry1988
type: Stoichiometry
physical entity: Protein6449
stoichiometric coefficient: 1.0

Stoichiometry1981
type: Stoichiometry
physical entity: Protein6429
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/19767751
type: PublicationXref
id: 19767751
author: Kosako, H
author: Hattori, S
author: Taniguchi, H
author: Kose, S
author: Ushiyama, M
author: Nishida, E
author: Imamoto, N
author: Aranami, C
author: Yamaguchi, N
db: Pubmed
title: Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
source: Nat Struct Mol Biol 16:1026-35
year: 2009

Stoichiometry1982
type: Stoichiometry
physical entity: SmallMolecule492
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

Stoichiometry1983
type: Stoichiometry
physical entity: Protein6437
stoichiometric coefficient: 1.0

Stoichiometry1984
type: Stoichiometry
physical entity: Protein6440
stoichiometric coefficient: 1.0

Stoichiometry1989
type: Stoichiometry
physical entity: Protein4380
stoichiometric coefficient: 2.0

Stoichiometry1991
type: Stoichiometry
physical entity: Complex873
stoichiometric coefficient: 1.0

Stoichiometry1990
type: Stoichiometry
physical entity: Protein4380
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

UnificationXref10347
type: UnificationXref
id: 6280021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280021

UnificationXref10346
type: UnificationXref
id: REACT_197975
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197975.3

UnificationXref10349
type: UnificationXref
id: 1500646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500646

UnificationXref10348
type: UnificationXref
id: REACT_208756
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_208756.2

UnificationXref10343
type: UnificationXref
id: 1498750
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498750

UnificationXref10342
type: UnificationXref
id: CHEBI:16870
db: ChEBI

UnificationXref10345
type: UnificationXref
id: 6275251
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275251

UnificationXref10344
type: UnificationXref
id: REACT_123948
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123948.1

UniProt:Q6UB39
type: ProteinReference
xref: UnificationXref853
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/15838516
type: PublicationXref
id: 15838516
author: Cobrinik, D
db: Pubmed
title: Pocket proteins and cell cycle control
source: Oncogene 24:2796-809
year: 2005

UniProt:Q94LF4
type: ProteinReference
xref: UnificationXref10641
organism: http://identifiers.org/taxonomy/4530

UnificationXref10340
type: UnificationXref
id: 6280007
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280007

UnificationXref10341
type: UnificationXref
id: REACT_215645
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215645.2

UnificationXref10359
type: UnificationXref
id: 6275212
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275212

UnificationXref10358
type: UnificationXref
id: Q6I628
db: UniProt

UnificationXref10357
type: UnificationXref
id: REACT_238537
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238537.1

UnificationXref10356
type: UnificationXref
id: 6275350
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275350

UnificationXref10355
type: UnificationXref
id: 6275348
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275348

UnificationXref10354
type: UnificationXref
id: 6275347
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275347

UnificationXref10353
type: UnificationXref
id: OS01T0118300-01
db: Ensembl

http://identifiers.org/pubmed/9153396
type: PublicationXref
id: 9153396
author: Vousden, KH
author: Kubbutat, MH
author: Jones, SN
db: Pubmed
title: Regulation of p53 stability by Mdm2.
source: Nature 387:299-303
year: 1997

http://identifiers.org/pubmed/9153395
type: PublicationXref
id: 9153395
author: Haupt, Y
author: Maya, R
author: Oren, M
author: Kazaz, A
db: Pubmed
title: Mdm2 promotes the rapid degradation of p53.
source: Nature 387:296-9
year: 1997

UnificationXref10351
type: UnificationXref
id: OS01T0683550-00
db: Ensembl

UnificationXref10352
type: UnificationXref
id: 6275344
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275344

UnificationXref10350
type: UnificationXref
id: REACT_125107
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125107.1

UnificationXref10365
type: UnificationXref
id: 6280019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280019

UnificationXref10364
type: UnificationXref
id: REACT_259810
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259810.1

UnificationXref10367
type: UnificationXref
id: CHEBI:52603
db: ChEBI

UnificationXref10366
type: UnificationXref
id: REACT_235112
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235112.1

UnificationXref10369
type: UnificationXref
id: REACT_121815
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121815.1

UnificationXref10368
type: UnificationXref
id: 1498724
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498724

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

UnificationXref10360
type: UnificationXref
id: H9BZX3
db: UniProt

UnificationXref10361
type: UnificationXref
id: 6275214
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275214

UnificationXref10362
type: UnificationXref
id: 6275215
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275215

UnificationXref10363
type: UnificationXref
id: 6275217
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275217

UnificationXref10378
type: UnificationXref
id: 6280011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280011

UnificationXref10377
type: UnificationXref
id: REACT_186235
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186235.3

UnificationXref10376
type: UnificationXref
id: 6275079
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275079

UnificationXref10375
type: UnificationXref
id: REACT_125069
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125069.1

UnificationXref10379
type: UnificationXref
id: REACT_212135
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212135.2

UniProt:Q94LI7
type: ProteinReference
xref: UnificationXref4306
organism: http://identifiers.org/taxonomy/4530

UnificationXref10370
type: UnificationXref
id: 6275052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275052

UnificationXref10373
type: UnificationXref
id: CHEBI:37646
db: ChEBI

Ensembl:OS12T0263000-01
type: ProteinReference
xref: UnificationXref15336
organism: http://identifiers.org/taxonomy/4530

UnificationXref10374
type: UnificationXref
id: 1498722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498722

UnificationXref10371
type: UnificationXref
id: 6275054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275054

UnificationXref10372
type: UnificationXref
id: REACT_186214
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186214.3

UniProt:A2ZYK7
type: ProteinReference
xref: UnificationXref10472
organism: http://identifiers.org/taxonomy/4530

UnificationXref10386
type: UnificationXref
id: 6275257
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275257

UnificationXref10387
type: UnificationXref
id: 6275258
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275258

UnificationXref10388
type: UnificationXref
id: 6275259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275259

UnificationXref10389
type: UnificationXref
id: 6275261
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275261

UnificationXref10383
type: UnificationXref
id: Q8S601
db: UniProt

UnificationXref10382
type: UnificationXref
id: REACT_123470
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123470.1

UnificationXref10385
type: UnificationXref
id: Q5JLS4
db: UniProt

UnificationXref10384
type: UnificationXref
id: 6275254
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275254

UnificationXref10381
type: UnificationXref
id: 426955
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426955

UnificationXref10380
type: UnificationXref
id: CHEBI:17962
db: ChEBI

UnificationXref10399
type: UnificationXref
id: 6280015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280015

UnificationXref10397
type: UnificationXref
id: 6275144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275144

UnificationXref10398
type: UnificationXref
id: REACT_197881
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197881.3

UnificationXref10396
type: UnificationXref
id: 6275142
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275142

UnificationXref10395
type: UnificationXref
id: 6275141
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275141

UnificationXref10394
type: UnificationXref
id: 6275140
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275140

UnificationXref10393
type: UnificationXref
id: Q0DC31
db: UniProt

UnificationXref10392
type: UnificationXref
id: 6275138
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275138

UnificationXref10391
type: UnificationXref
id: Q6Z717
db: UniProt

UnificationXref10390
type: UnificationXref
id: REACT_215711
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215711.2

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
type: Pathway
data source: Provenance1
pathway component: REACT 234867.1
pathway component: BiochemicalReaction1005
evidence: Evidence1490
xref: UnificationXref15988
xref: UnificationXref15989
pathway order: PathwayStep1472
pathway order: PathwayStep1473
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/59727
type: PublicationXref
id: 59727
author: Nachman, RL
author: Harpel, PC
db: Pubmed
title: Platelet alpha2-macroglobulin and alpha1-antitrypsin
source: J Biol Chem 251:4512-21
year: 1976

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

Ensembl:OS06T0610100-00
type: ProteinReference
xref: UnificationXref15712
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

Synthesis of UDP-N-acetyl-glucosamine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1171
pathway component: BiochemicalReaction1174
pathway component: BiochemicalReaction1172
pathway component: BiochemicalReaction1173
evidence: Evidence1802
xref: RelationshipXref1533
xref: UnificationXref19407
xref: UnificationXref19406
pathway order: PathwayStep1780
pathway order: PathwayStep1779
pathway order: PathwayStep1777
pathway order: PathwayStep1778
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Ensembl:OS12T0212100-00
type: ProteinReference
xref: UnificationXref15796
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/16616430
type: PublicationXref
id: 16616430
author: Conti, F
author: Varoqui, H
author: Melone, M
author: Erickson, JD
db: Pubmed
title: Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex
source: Neuroscience 140:281-92
year: 2006

UniProt:A2ZZB2
type: ProteinReference
xref: UnificationXref17841
organism: http://identifiers.org/taxonomy/4530

Ensembl:OS08T0177600-00
type: ProteinReference
xref: UnificationXref16065
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/15526160
type: PublicationXref
id: 15526160
author: Rönnstrand, L
db: Pubmed
title: Signal transduction via the stem cell factor receptor/c-Kit
source: Cell Mol Life Sci 61:2535-48
year: 2004

uridine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_15713
data source: Provenance1
name: Uridine triphosphate
xref: UnificationXref1773
xref: UnificationXref1774
cellular location: GO_0005654
comment: Reactome DB_ID: 113562
display name: UTP

Deoxythymidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_18077
data source: Provenance1
name: dTTP
name: Deoxythymidine triphosphate
xref: UnificationXref1782
xref: UnificationXref1783
cellular location: GO_0005654
comment: Reactome DB_ID: 30187
display name: TTP

Water
type: SmallMolecule
entity reference: CHEBI_15377
data source: Provenance1
xref: UnificationXref1079
xref: UnificationXref1078
cellular location: GO_0005829
comment: Reactome DB_ID: 29356
display name: H2O

NTP
type: SmallMolecule
data source: Provenance1
member physical entity: uridine 5'-triphosphate
member physical entity: cytidine 5'-triphosphate
member physical entity: Adenosine 5'-triphosphate
member physical entity: Guanosine 5'-triphosphate
xref: UnificationXref1775
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6254604

cytidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_17677
data source: Provenance1
name: Cytidine triphosphate
xref: UnificationXref1768
xref: UnificationXref1769
cellular location: GO_0005654
comment: Reactome DB_ID: 29470
display name: CTP

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_15996
data source: Provenance1
xref: UnificationXref1770
xref: UnificationXref1771
cellular location: GO_0005654
comment: Reactome DB_ID: 113571
display name: GTP

5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence663
conversion direction: LEFT_TO_RIGHT
EC number: 1.5.1.20
xref: UnificationXref7943
xref: UnificationXref7944
left: proton
left: NADPH
left: SmallMolecule463
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule457

5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence664
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.2.1
xref: UnificationXref7946
xref: UnificationXref7945
left: SmallMolecule123
left: SmallMolecule463
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule455
right: SmallMolecule116

5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence665
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7947
xref: UnificationXref7948
left: NADP+
left: SmallMolecule463
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: NADPH
right: SmallMolecule462

UnificationXref10330
type: UnificationXref
id: 6274995
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274995

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence666
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.9
xref: UnificationXref7949
xref: UnificationXref7950
left: Water
left: SmallMolecule462
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule461

Cyclisation of GTP to precursor Z
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence668
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7987
xref: UnificationXref7986
left: SmallMolecule1
left: Water
left: SmallMolecule464
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule466
right: SmallMolecule465
right: SmallMolecule115

NFS1 transfers sulfur from cysteine onto MOCS3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence669
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.1.7
xref: UnificationXref8002
xref: UnificationXref8003
left: Complex412
left: SmallMolecule176
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex413
right: SmallMolecule113

Transfer of sulfur from MOCS3-S-S onto MOCS2A
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence670
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.1
xref: UnificationXref8009
xref: UnificationXref8010
left: Protein3409
left: Complex413
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: Complex415
right: SmallMolecule7
right: Protein3410

Sulfhydrylation and ring cleavage of precursor Z
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence671
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8018
xref: UnificationXref8017
left: Water
left: Complex416
left: SmallMolecule465
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule467
right: Complex417

UnificationXref10335
type: UnificationXref
id: CHEBI:16728
db: ChEBI

UnificationXref10336
type: UnificationXref
id: 975614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=975614

UnificationXref10337
type: UnificationXref
id: REACT_26354
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26354.2

UnificationXref10338
type: UnificationXref
id: 6275003
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275003

UnificationXref10331
type: UnificationXref
id: 6274996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274996

UnificationXref10332
type: UnificationXref
id: 6275001
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275001

(Indol-3-yl)pyruvate
type: SmallMoleculeReference
name: ChEBI:29750 3-(indol-3-yl)pyruvic acid
name: Indolepyruvic acid
name: 3-(Indol-3-yl)pyruvate
name: Indole-3-pyruvate
name: Indolepyruvate
name: 3-(indol-3-yl)pyruvic acid
xref: UnificationXref13718

Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence662
conversion direction: LEFT_TO_RIGHT
EC number: 2.1.2.1
xref: UnificationXref7938
xref: UnificationXref7939
left: SmallMolecule455
left: SmallMolecule116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule123
right: SmallMolecule463

UnificationXref10333
type: UnificationXref
id: 6275043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275043

5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence661
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7927
xref: UnificationXref7926
left: proton
left: NADPH
left: SmallMolecule462
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule463

UnificationXref10334
type: UnificationXref
id: REACT_186154
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186154.3

1,2-diacyl-sn-glycerol
type: SmallMolecule
entity reference: CHEBI_17815
data source: Provenance1
name: 1,2-diacylglycerol
xref: UnificationXref829
xref: UnificationXref828
cellular location: GO_0005635
comment: Reactome DB_ID: 5221124
display name: DAG

Water
type: SmallMolecule
entity reference: CHEBI_15377
data source: Provenance1
xref: UnificationXref826
xref: UnificationXref825
cellular location: GO_0005654
comment: Reactome DB_ID: 113518
display name: H2O

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI_15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref973
xref: UnificationXref972
cellular location: GO_0005829
comment: Reactome DB_ID: 76183
display name: Ac-CoA

coenzyme A
type: SmallMolecule
entity reference: CHEBI_15346
data source: Provenance1
xref: UnificationXref920
xref: UnificationXref919
cellular location: GO_0005829
comment: Reactome DB_ID: 76194
display name: CoA-SH

UnificationXref10339
type: UnificationXref
id: REACT_186522
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186522.3

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref3125
xref: UnificationXref3124
cellular location: GO_0005829
comment: Reactome DB_ID: 29472
display name: L-Gln

Sodium
type: SmallMolecule
entity reference: CHEBI_29101
data source: Provenance1
name: sodium ion
xref: UnificationXref3120
xref: UnificationXref3119
cellular location: GO_0005576
comment: Reactome DB_ID: 74113
display name: Na+

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref3123
xref: UnificationXref3122
cellular location: GO_0005576
comment: Reactome DB_ID: 212615
display name: L-Gln

Coenzyme A
type: SmallMolecule
entity reference: CHEBI_15346
data source: Provenance1
name: CoA-SH
xref: UnificationXref2648
xref: UnificationXref2647
cellular location: GO_0005654
comment: Reactome DB_ID: 2485002
display name: CoA

G-strand Chromosome end with two additional single strand repeats - Telomeric
type: SmallMolecule
entity reference: CHEBI_15986
data source: Provenance1
xref: UnificationXref3028
xref: UnificationXref3029
cellular location: GO_0005654
comment: Reactome DB_ID: 163085
display name: NNNNNNNNNNNTTAGGGTTATTAGGGTTATTAGGGTTA - 3' (in human)

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence701
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.11
xref: UnificationXref8182
xref: UnificationXref8183
left: Water
left: SmallMolecule314
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule471
right: SmallMolecule315

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence702
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.11
xref: UnificationXref8254
xref: UnificationXref8255
left: Water
left: SmallMolecule314
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule471
right: SmallMolecule315

Hh processing variants are ubiquitinated
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence695
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: UnificationXref8112
xref: UnificationXref8111
left: PhysicalEntity24
left: Complex421
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex421

SYVN1 ubiquitinates Hh C-terminal fragments
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence697
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: UnificationXref8117
xref: UnificationXref8116
left: PhysicalEntity24
left: Complex421
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex426

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence705
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.56
xref: UnificationXref8356
xref: UnificationXref8355
left: Water
left: SmallMolecule476
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule477

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by PLCD4 at the ER membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence703
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.11
xref: UnificationXref8266
xref: UnificationXref8265
left: SmallMolecule473
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule474
right: SmallMolecule315

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence704
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.56
xref: UnificationXref8320
xref: UnificationXref8319
left: Water
left: SmallMolecule476
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule477

UnificationXref10326
type: UnificationXref
id: 6275102
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275102

UnificationXref10327
type: UnificationXref
id: REACT_186264
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186264.3

UnificationXref10324
type: UnificationXref
id: 1524028
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524028

UnificationXref10325
type: UnificationXref
id: REACT_122985
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122985.1

Defective HLCS does not biotinylate apo-CBXs
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence690
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8077
xref: UnificationXref8076
left: SmallMolecule5
left: Complex399
left: SmallMolecule445
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

UnificationXref10322
type: UnificationXref
id: 6280017
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280017

Exchange of oxygen with sulfur in MoCo
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence673
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8043
xref: UnificationXref8042
left: SmallMolecule176
left: SmallMolecule469
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule470
right: SmallMolecule113

UnificationXref10323
type: UnificationXref
id: REACT_219341
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219341.2

Molybdenum ion transfer onto molybdopterin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence672
conversion direction: LEFT_TO_RIGHT
EC number: 2
xref: UnificationXref8035
xref: UnificationXref8034
left: Water
left: SmallMolecule5
left: SmallMolecule468
left: SmallMolecule467
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule469
right: SmallMolecule7

UnificationXref10320
type: UnificationXref
id: 6275408
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275408

http://identifiers.org/pubmed/17035228
type: PublicationXref
id: 17035228
author: Ron, D
author: Zilpa, T
author: Shabtay, A
author: Dym, N
author: Preger, E
author: Ziv, I
author: Harduf, H
author: Fuchs, Y
db: Pubmed
title: The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate
source: J Biol Chem 281:39225-35
year: 2006

UnificationXref10321
type: UnificationXref
id: REACT_175235
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175235.3

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI_15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref2645
xref: UnificationXref2646
cellular location: GO_0005654
comment: Reactome DB_ID: 113560
display name: Ac-CoA

Phosphate
type: SmallMolecule
entity reference: CHEBI_18367
data source: Provenance1
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref2282
xref: UnificationXref2281
cellular location: GO_0005654
comment: Reactome DB_ID: 113550
display name: Pi

deoxycytidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_16311
data source: Provenance1
name: Deoxycytidine triphosphate
name: 2'-Deoxycytidine 5'-triphosphate
xref: UnificationXref1791
xref: UnificationXref1792
cellular location: GO_0005654
comment: Reactome DB_ID: 30185
display name: dCTP

2'-deoxyadenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_16284
data source: Provenance1
name: Deoxyadenosine 5'-triphosphate
name: Deoxyadenosine triphosphate
xref: UnificationXref1788
xref: UnificationXref1789
cellular location: GO_0005654
comment: Reactome DB_ID: 29604
display name: dATP

2'-deoxyguanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_16497
data source: Provenance1
name: Deoxyguanosine 5'-triphosphate
name: Deoxyguanosine triphosphate
xref: UnificationXref1786
xref: UnificationXref1785
cellular location: GO_0005654
comment: Reactome DB_ID: 29892
display name: dGTP

UnificationXref10328
type: UnificationXref
id: 6274993
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274993

UnificationXref10329
type: UnificationXref
id: 6274994
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274994

NADH
type: SmallMolecule
entity reference: CHEBI_16908
data source: Provenance1
xref: UnificationXref594
xref: UnificationXref595
cellular location: GO_0005829
comment: Reactome DB_ID: 73473

pregn-5-ene-3,20-dione-17-ol
type: SmallMolecule
entity reference: CHEBI_63843
data source: Provenance1
xref: UnificationXref597
xref: UnificationXref598
cellular location: GO_0005829
comment: Reactome DB_ID: 196366

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

proton
type: SmallMolecule
entity reference: CHEBI_15378
data source: Provenance1
xref: UnificationXref600
xref: UnificationXref601
cellular location: GO_0005829
comment: Reactome DB_ID: 70106
display name: H+

UniProt:Q6PL11
type: ProteinReference
xref: UnificationXref2348
organism: http://identifiers.org/taxonomy/4530

17alpha-hydroxyprogesterone
type: SmallMolecule
entity reference: CHEBI_17252
data source: Provenance1
xref: UnificationXref613
xref: UnificationXref614
cellular location: GO_0005829
comment: Reactome DB_ID: 193092

Cortisol
type: SmallMolecule
entity reference: CHEBI_17650
data source: Provenance1
xref: UnificationXref618
xref: UnificationXref619
cellular location: GO_0005829
comment: Reactome DB_ID: 193977
display name: CORT

NADP+
type: SmallMolecule
entity reference: CHEBI_18009
data source: Provenance1
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref622
xref: UnificationXref621
cellular location: GO_0005829
comment: Reactome DB_ID: 29366
display name: TPN

Cortisone
type: SmallMolecule
entity reference: CHEBI_16962
data source: Provenance1
xref: UnificationXref625
xref: UnificationXref624
cellular location: GO_0005829
comment: Reactome DB_ID: 194035
display name: COR

NADPH
type: SmallMolecule
entity reference: CHEBI_16474
data source: Provenance1
xref: UnificationXref627
xref: UnificationXref628
cellular location: GO_0005829
comment: Reactome DB_ID: 29364
display name: TPNH

UnificationXref10310
type: UnificationXref
id: 6275206
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275206

UnificationXref10311
type: UnificationXref
id: 6275207
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275207

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

UnificationXref10312
type: UnificationXref
id: 6275416
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275416

UnificationXref10313
type: UnificationXref
id: REACT_175233
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175233.3

UnificationXref10314
type: UnificationXref
id: 6275208
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275208

UnificationXref10315
type: UnificationXref
id: 6275209
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275209

UnificationXref10316
type: UnificationXref
id: REACT_197945
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197945.3

UnificationXref10317
type: UnificationXref
id: 6275398
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275398

http://identifiers.org/pubmed/9741684
type: PublicationXref
id: 9741684
author: Edwards, PA
author: Shell, BK
author: Greene, JM
author: Ericsson, J
author: Carter, KC
author: Florence, C
author: Duan, DR
db: Pubmed
title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
source: J Lipid Res 39:1731-9
year: 1998

UnificationXref10318
type: UnificationXref
id: 6275399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275399

UnificationXref10319
type: UnificationXref
id: REACT_175145
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175145.3

17alpha-hydroxypregnenolone
type: SmallMolecule
entity reference: CHEBI_28750
data source: Provenance1
xref: UnificationXref591
xref: UnificationXref592
cellular location: GO_0005829
comment: Reactome DB_ID: 193124

DPN
type: SmallMolecule
entity reference: CHEBI_15846
data source: Provenance1
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref588
xref: UnificationXref589
cellular location: GO_0005829
comment: Reactome DB_ID: 29360
display name: NAD

Testosterone
type: SmallMolecule
entity reference: CHEBI_17347
data source: Provenance1
xref: UnificationXref684
xref: UnificationXref683
cellular location: GO_0005829
comment: Reactome DB_ID: 193057
display name: TES

5-alpha-dihydrotestosterone
type: SmallMolecule
entity reference: CHEBI_16330
data source: Provenance1
xref: UnificationXref715
xref: UnificationXref714
cellular location: GO_0005829
comment: Reactome DB_ID: 469662
display name: DHTEST

dehydroepiandrosterone
type: SmallMolecule
entity reference: CHEBI_28689
data source: Provenance1
xref: UnificationXref675
xref: UnificationXref676
cellular location: GO_0005829
comment: Reactome DB_ID: 176626
display name: DHEA

Ensembl:OS08T0426000-00
type: ProteinReference
xref: UnificationXref16242
organism: http://identifiers.org/taxonomy/4530

4-Androstene-3, 17-dione
type: SmallMolecule
entity reference: CHEBI_16422
data source: Provenance1
xref: UnificationXref679
xref: UnificationXref678
cellular location: GO_0005829
comment: Reactome DB_ID: 193079

1,2-diacyl-glycerol 3-phosphate
type: SmallMolecule
entity reference: CHEBI_29089
data source: Provenance1
xref: UnificationXref823
xref: UnificationXref822
cellular location: GO_0005635
comment: Reactome DB_ID: 5221122
display name: Phosphatidic acid

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_15422
data source: Provenance1
xref: UnificationXref768
xref: UnificationXref769
cellular location: GO_0005654
comment: Reactome DB_ID: 29358
display name: ATP

10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence660
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.4.9
xref: UnificationXref7922
xref: UnificationXref7921
left: SmallMolecule461
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule462

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI_16761
data source: Provenance1
xref: UnificationXref784
xref: UnificationXref785
cellular location: GO_0005654
comment: Reactome DB_ID: 113582
display name: ADP

Conversion of mitochondrial THF to THF-polyglutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence658
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.17
xref: UnificationXref7903
xref: UnificationXref7902
participant stoichiometry: Stoichiometry993
participant stoichiometry: Stoichiometry994
participant stoichiometry: Stoichiometry995
participant stoichiometry: Stoichiometry996
left: SmallMolecule458
left: L-Glutaminic acid
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Adenosine 5'-diphosphate
right: SmallMolecule459

THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence659
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.4.3
xref: UnificationXref7916
xref: UnificationXref7917
left: SmallMolecule460
left: SmallMolecule5
left: SmallMolecule455
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule461

Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence656
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7889
xref: UnificationXref7888
left: SmallMolecule454
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule458

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence657
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref7890
xref: UnificationXref7891
left: SmallMolecule458
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule454

Conversion of cytosolic THF to THF-polyglutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence654
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.17
xref: UnificationXref7871
xref: UnificationXref7872
participant stoichiometry: Stoichiometry987
participant stoichiometry: Stoichiometry986
participant stoichiometry: Stoichiometry988
participant stoichiometry: Stoichiometry985
left: L-Glutaminic acid
left: SmallMolecule5
left: SmallMolecule454
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule455

Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence655
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.17
xref: UnificationXref7879
xref: UnificationXref7880
participant stoichiometry: Stoichiometry989
participant stoichiometry: Stoichiometry990
participant stoichiometry: Stoichiometry991
participant stoichiometry: Stoichiometry992
left: L-Glutaminic acid
left: SmallMolecule5
left: SmallMolecule456
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule457

NAD+ is phosphorylated to NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence650
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.23
xref: UnificationXref7827
xref: UnificationXref7826
left: SmallMolecule5
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule6

A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence651
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.2.11
xref: UnificationXref7843
xref: UnificationXref7844
left: proton
left: SmallMolecule414
left: SmallMolecule453
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule447
right: SmallMolecule340

Amidation of deamino-NAD+ to NAD+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence649
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.5.1
xref: UnificationXref7819
xref: UnificationXref7818
left: L-Glutamine
left: Water
left: SmallMolecule5
left: SmallMolecule452
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: SmallMolecule340
right: SmallMolecule7
right: DPN

UnificationXref10300
type: UnificationXref
id: 6279923
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279923

UnificationXref10301
type: UnificationXref
id: REACT_204970
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204970.2

UnificationXref10304
type: UnificationXref
id: REACT_123561
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123561.1

UnificationXref10305
type: UnificationXref
id: Q10N10
db: UniProt

UnificationXref10302
type: UnificationXref
id: CHEBI:16749
db: ChEBI

UnificationXref10303
type: UnificationXref
id: 426639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426639

UnificationXref10308
type: UnificationXref
id: 1524146
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524146

UnificationXref10309
type: UnificationXref
id: REACT_122034
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122034.1

UnificationXref10306
type: UnificationXref
id: 6275397
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275397

UnificationXref10307
type: UnificationXref
id: 6275407
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275407

Progesterone
type: SmallMolecule
entity reference: CHEBI_17026
data source: Provenance1
xref: UnificationXref668
xref: UnificationXref669
cellular location: GO_0005829
comment: Reactome DB_ID: 193055
display name: P4

pregn-5-ene-3,20-dione
type: SmallMolecule
entity reference: CHEBI_63837
data source: Provenance1
xref: UnificationXref663
xref: UnificationXref664
cellular location: GO_0005829
comment: Reactome DB_ID: 196344

Pregnenolone
type: SmallMolecule
entity reference: CHEBI_16581
data source: Provenance1
xref: UnificationXref661
xref: UnificationXref660
cellular location: GO_0005829
comment: Reactome DB_ID: 193103
display name: PREG

UnificationXref14850
type: UnificationXref
id: 6266631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266631

http://identifiers.org/pubmed/10101268
type: PublicationXref
id: 10101268
author: Heilmeyer LM, Jr
author: Gehrmann, T
author: Balla, A
author: Herberg, FW
author: Mayr, Georg W
author: Suer, S
author: Gülkan, H
author: Vereb, G
db: Pubmed
title: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230
source: Biochim Biophys Acta 1437:341-56
year: 1999

UnificationXref14851
type: UnificationXref
id: 6266632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266632

I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence730
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8502
xref: UnificationXref8501
left: Water
left: SmallMolecule501
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule186

I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence731
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.25
xref: UnificationXref8506
xref: UnificationXref8507
left: SmallMolecule502
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule186

NPC1L1-mediated cholesterol uptake
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence736
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8531
xref: UnificationXref8530
left: cholesterol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: cholesterol

NPC1L1-mediated phytosterol uptake
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence737
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8533
xref: UnificationXref8532
left: phytosterols
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: phytosterols

Glc6P is isomerised to I3P by ISYNA1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence732
conversion direction: LEFT_TO_RIGHT
EC number: 5.5.1.4
xref: UnificationXref8521
xref: UnificationXref8520
left: SmallMolecule503
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule504

I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence733
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8523
xref: UnificationXref8522
left: SmallMolecule504
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule186

Stoichiometry1940
type: Stoichiometry
physical entity: SmallMolecule1280
stoichiometric coefficient: 2.0

Transport of Citrate from Mitochondrial Matrix to cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence746
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8645
xref: UnificationXref8646
left: SmallMolecule398
left: SmallMolecule144
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule194
right: SmallMolecule146

2-acylglycerol + H2O -> glycerol + fatty acid
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence743
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.23
xref: UnificationXref8640
xref: UnificationXref8639
left: SmallMolecule510
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule511
right: SmallMolecule512

cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence740
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.43
xref: UnificationXref8579
xref: UnificationXref8578
left: cholesterol
left: SmallMolecule507
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule509
right: SmallMolecule508

NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence738
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8541
xref: UnificationXref8540
left: SmallMolecule505
left: Protein3602
display name: NPC1L1 inactivation by ezetimibe
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex449

Stoichiometry1944
type: Stoichiometry
physical entity: Complex852
stoichiometric coefficient: 1.0

Stoichiometry1943
type: Stoichiometry
physical entity: Complex850
stoichiometric coefficient: 1.0

Stoichiometry1942
type: Stoichiometry
physical entity: Complex852
stoichiometric coefficient: 2.0

Stoichiometry1941
type: Stoichiometry
physical entity: SmallMolecule1279
stoichiometric coefficient: 1.0

Stoichiometry1948
type: Stoichiometry
physical entity: SmallMolecule1281
stoichiometric coefficient: 1.0

UnificationXref14855
type: UnificationXref
id: 6266636
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266636

Purine catabolism
type: Pathway
data source: Provenance1
pathway component: 2 H2O2 => O2 + 2 H2O
pathway component: Hypoxanthine + H2O + O2 => Xanthine + H2O2
pathway component: Xanthine + H2O + O2 => Urate + H2O2
pathway component: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
pathway component: Guanine + H2O => Xanthine + NH3
evidence: Evidence1169
xref: UnificationXref12724
xref: RelationshipXref1048
xref: UnificationXref12723
pathway order: PathwayStep1150
pathway order: PathwayStep1151
pathway order: PathwayStep1152
pathway order: PathwayStep1153
pathway order: PathwayStep1154
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1947
type: Stoichiometry
physical entity: Protein6385
stoichiometric coefficient: 1.0

UnificationXref14854
type: UnificationXref
id: 6266635
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266635

Stoichiometry1946
type: Stoichiometry
physical entity: Complex853
stoichiometric coefficient: 2.0

UnificationXref14853
type: UnificationXref
id: 6266634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266634

http://identifiers.org/pubmed/10615129
type: PublicationXref
id: 10615129
author: Mauro, T
author: Ikeda, S
author: Bonifas, JM
author: Beech, J
author: Bench, G
author: Ogawa, H
author: Hu, Z
author: Shigihara, T
author: Epstein EH, Jr
db: Pubmed
title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
source: Nat Genet 24:61-5
year: 2000

Stoichiometry1945
type: Stoichiometry
physical entity: Complex853
stoichiometric coefficient: 2.0

UnificationXref14852
type: UnificationXref
id: 6266633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266633

UnificationXref14859
type: UnificationXref
id: 6266640
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266640

UnificationXref14858
type: UnificationXref
id: 6266639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266639

UnificationXref14857
type: UnificationXref
id: 6266638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266638

Stoichiometry1949
type: Stoichiometry
physical entity: SmallMolecule1279
stoichiometric coefficient: 1.0

UnificationXref14856
type: UnificationXref
id: 6266637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266637

UnificationXref14840
type: UnificationXref
id: 6266621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266621

Generation of Cytoplasmic Acetyl CoA from Citrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence747
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.3.8
xref: UnificationXref8657
xref: UnificationXref8658
left: SmallMolecule5
left: SmallMolecule194
left: coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule329
right: Acetyl coenzyme A

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence748
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref8674
xref: UnificationXref8673
left: SmallMolecule5
left: coenzyme A
left: SmallMolecule513
display name: Conversion of palmitic acid to palmitoyl-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule514

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence749
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref8690
xref: UnificationXref8689
left: SmallMolecule5
left: coenzyme A
left: SmallMolecule513
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule514

arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence750
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref8697
xref: UnificationXref8698
left: SmallMolecule5
left: coenzyme A
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule516

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence751
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref8706
xref: UnificationXref8707
left: SmallMolecule5
left: coenzyme A
left: SmallMolecule513
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule514

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence752
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref8713
xref: UnificationXref8714
left: SmallMolecule5
left: coenzyme A
left: SmallMolecule513
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule340
right: SmallMolecule7
right: SmallMolecule514

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence753
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8723
xref: UnificationXref8724
left: SmallMolecule517
left: SmallMolecule514
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: coenzyme A
right: SmallMolecule518

lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence755
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8736
xref: UnificationXref8735
left: SmallMolecule519
left: SmallMolecule517
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule520
right: coenzyme A

UnificationXref14849
type: UnificationXref
id: 6266630
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266630

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence754
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8726
xref: UnificationXref8727
left: SmallMolecule517
left: SmallMolecule514
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: coenzyme A
right: SmallMolecule518

Stoichiometry1951
type: Stoichiometry
physical entity: Protein6384
stoichiometric coefficient: 1.0

Stoichiometry1950
type: Stoichiometry
physical entity: Complex855
stoichiometric coefficient: 2.0

arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence756
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8742
xref: UnificationXref8743
left: SmallMolecule517
left: SmallMolecule516
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule521
right: coenzyme A

Stoichiometry1953
type: Stoichiometry
physical entity: SmallMolecule1279
stoichiometric coefficient: 1.0

Stoichiometry1952
type: Stoichiometry
physical entity: SmallMolecule1280
stoichiometric coefficient: 1.0

Stoichiometry1955
type: Stoichiometry
physical entity: SmallMolecule1282
stoichiometric coefficient: 2.0

Stoichiometry1954
type: Stoichiometry
physical entity: Complex857
stoichiometric coefficient: 2.0

Stoichiometry1957
type: Stoichiometry
physical entity: SmallMolecule1283
stoichiometric coefficient: 2.0

UnificationXref14842
type: UnificationXref
id: 6266623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266623

Stoichiometry1956
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

UnificationXref14841
type: UnificationXref
id: 6266622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266622

Stoichiometry1959
type: Stoichiometry
physical entity: SmallMolecule1284
stoichiometric coefficient: 2.0

UnificationXref14844
type: UnificationXref
id: 6266625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266625

Stoichiometry1958
type: Stoichiometry
physical entity: SmallMolecule888
stoichiometric coefficient: 2.0

UnificationXref14843
type: UnificationXref
id: 6266624
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266624

UnificationXref14846
type: UnificationXref
id: 6266627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266627

UnificationXref14845
type: UnificationXref
id: 6266626
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266626

UnificationXref14848
type: UnificationXref
id: 6266629
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266629

UnificationXref14847
type: UnificationXref
id: 6266628
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266628

I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence708
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8365
xref: UnificationXref8364
left: Water
left: SmallMolecule478
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule477

I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence709
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8370
xref: UnificationXref8369
left: Water
left: SmallMolecule478
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule479

I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence706
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8358
xref: UnificationXref8357
left: SmallMolecule477
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule476
right: SmallMolecule6

http://identifiers.org/pubmed/15175005
type: PublicationXref
id: 15175005
author: Stewart, AJ
author: Sadler, PJ
author: Roberts, SJ
author: Farquharson, C
db: Pubmed
title: Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities
source: Biochem J 382:59-65
year: 2004

I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence707
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8362
xref: UnificationXref8363
left: SmallMolecule477
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule478
right: SmallMolecule6

Stoichiometry1922
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Stoichiometry1921
type: Stoichiometry
physical entity: Protein6363
stoichiometric coefficient: 2.0

Stoichiometry1920
type: Stoichiometry
physical entity: Complex843
stoichiometric coefficient: 2.0

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence716
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.158
xref: UnificationXref8402
xref: UnificationXref8403
left: Adenosine 5'-triphosphate
left: SmallMolecule482
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule485
right: Adenosine 5'-diphosphate

I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence715
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8396
xref: UnificationXref8395
left: SmallMolecule484
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule482

I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence714
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.140
xref: UnificationXref8391
xref: UnificationXref8390
left: SmallMolecule483
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule482

I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence713
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8386
xref: UnificationXref8387
left: Adenosine 5'-triphosphate
left: SmallMolecule481
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule482

UnificationXref14839
type: UnificationXref
id: 6266620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266620

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence712
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.127
xref: UnificationXref8382
xref: UnificationXref8381
left: Adenosine 5'-triphosphate
left: SmallMolecule480
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: SmallMolecule481

UnificationXref14838
type: UnificationXref
id: Q9FW33
db: UniProt

I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence710
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8371
xref: UnificationXref8372
left: SmallMolecule5
left: SmallMolecule479
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule478
right: SmallMolecule6

UnificationXref14837
type: UnificationXref
id: 6266619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266619

http://identifiers.org/pubmed/11322953
type: PublicationXref
id: 11322953
author: Ishida, N
author: Kawakita, M
author: Muraoka, M
db: Pubmed
title: Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
source: FEBS Lett 495:87-93
year: 2001

Stoichiometry1929
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

UnificationXref14836
type: UnificationXref
id: Q7EZ53
db: UniProt

Stoichiometry1928
type: Stoichiometry
physical entity: Protein6370
stoichiometric coefficient: 1.0

UnificationXref14835
type: UnificationXref
id: 6266618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266618

Stoichiometry1927
type: Stoichiometry
physical entity: Complex844
stoichiometric coefficient: 2.0

UnificationXref14834
type: UnificationXref
id: D0PQ37
db: UniProt

Stoichiometry1926
type: Stoichiometry
physical entity: Complex844
stoichiometric coefficient: 2.0

UnificationXref14833
type: UnificationXref
id: 6266617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266617

Stoichiometry1925
type: Stoichiometry
physical entity: Complex843
stoichiometric coefficient: 1.0

UnificationXref14832
type: UnificationXref
id: Q6ZDE3
db: UniProt

Stoichiometry1924
type: Stoichiometry
physical entity: Complex845
stoichiometric coefficient: 1.0

UnificationXref14831
type: UnificationXref
id: 6266616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266616

Stoichiometry1923
type: Stoichiometry
physical entity: Protein6363
stoichiometric coefficient: 1.0

UnificationXref14830
type: UnificationXref
id: Q0D610
db: UniProt

I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence719
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.134
xref: UnificationXref8413
xref: UnificationXref8414
left: SmallMolecule487
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule486
right: SmallMolecule6

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence720
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.158
xref: UnificationXref8419
xref: UnificationXref8418
left: SmallMolecule486
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule488
right: SmallMolecule6

IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence721
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8439
xref: UnificationXref8438
left: SmallMolecule5
left: SmallMolecule488
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule489
right: SmallMolecule6

5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence722
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8447
xref: UnificationXref8446
left: SmallMolecule5
left: SmallMolecule490
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule491

I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence718
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8412
xref: UnificationXref8411
left: SmallMolecule486
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule487

Stoichiometry1931
type: Stoichiometry
physical entity: Complex847
stoichiometric coefficient: 2.0

Stoichiometry1930
type: Stoichiometry
physical entity: SmallMolecule295
stoichiometric coefficient: 1.0

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence729
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.56
xref: UnificationXref8483
xref: UnificationXref8484
left: Water
left: SmallMolecule315
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule500

Stoichiometry1933
type: Stoichiometry
physical entity: Protein6362
stoichiometric coefficient: 1.0

Stoichiometry1932
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

UnificationXref14828
type: UnificationXref
id: Q6F4F5
db: UniProt

I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence725
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8466
xref: UnificationXref8467
left: SmallMolecule496
left: SmallMolecule492
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule495
right: SmallMolecule497

UnificationXref14827
type: UnificationXref
id: 6266614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266614

I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence724
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8460
xref: UnificationXref8461
left: SmallMolecule493
left: SmallMolecule492
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule494
right: SmallMolecule495

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence728
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.56
xref: UnificationXref8482
xref: UnificationXref8481
left: Water
left: SmallMolecule315
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule500

UnificationXref14829
type: UnificationXref
id: 6266615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266615

IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence726
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8473
xref: UnificationXref8474
left: SmallMolecule498
left: SmallMolecule492
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule499
right: SmallMolecule495

Stoichiometry1939
type: Stoichiometry
physical entity: Protein6384
stoichiometric coefficient: 1.0

UnificationXref14824
type: UnificationXref
id: C7J2P9
db: UniProt

Stoichiometry1938
type: Stoichiometry
physical entity: Complex850
stoichiometric coefficient: 2.0

UnificationXref14823
type: UnificationXref
id: 6266612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266612

UnificationXref14826
type: UnificationXref
id: Q850S5
db: UniProt

UnificationXref14825
type: UnificationXref
id: 6266613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266613

Stoichiometry1935
type: Stoichiometry
physical entity: Complex849
stoichiometric coefficient: 2.0

UnificationXref14820
type: UnificationXref
id: Q8H522
db: UniProt

Stoichiometry1934
type: Stoichiometry
physical entity: SmallMolecule1278
stoichiometric coefficient: 1.0

Stoichiometry1937
type: Stoichiometry
physical entity: SmallMolecule1279
stoichiometric coefficient: 1.0

UnificationXref14822
type: UnificationXref
id: Q5CCK1
db: UniProt

Stoichiometry1936
type: Stoichiometry
physical entity: Protein6377
stoichiometric coefficient: 1.0

UnificationXref14821
type: UnificationXref
id: 6266611
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266611

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence810
conversion direction: LEFT_TO_RIGHT
EC number: 4.1
xref: UnificationXref9304
xref: UnificationXref9305
left: SmallMolecule560
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule562
right: SmallMolecule561

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence809
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9282
xref: UnificationXref9281
left: SmallMolecule5
left: SmallMolecule558
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7
right: SmallMolecule559

Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence801
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9239
xref: UnificationXref9238
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein3853

Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence794
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9168
xref: UnificationXref9167
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein3804

3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence815
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref9355
xref: UnificationXref9356
left: SmallMolecule571
left: SmallMolecule572
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule575
right: SmallMolecule573
right: SmallMolecule574

trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence814
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.74
xref: UnificationXref9344
xref: UnificationXref9345
left: SmallMolecule567
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule571

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence813
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9335
xref: UnificationXref9334
left: SmallMolecule566
left: SmallMolecule565
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule567
right: SmallMolecule568

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence812
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9325
xref: UnificationXref9324
left: SmallMolecule566
left: SmallMolecule565
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule567
right: SmallMolecule568

UnificationXref14891
type: UnificationXref
id: 6266672
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266672

UnificationXref14890
type: UnificationXref
id: 6266671
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266671

Stoichiometry1909
type: Stoichiometry
physical entity: Protein6326
stoichiometric coefficient: 1.0

UnificationXref14895
type: UnificationXref
id: 6266676
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266676

Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence793
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.5.3
EC number: 1.1.99.5
xref: UnificationXref9055
xref: UnificationXref9054
left: SmallMolecule554
left: SmallMolecule555
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule556
right: SmallMolecule557

UnificationXref14894
type: UnificationXref
id: 6266675
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266675

acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence790
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.9
xref: UnificationXref9032
xref: UnificationXref9033
participant stoichiometry: Stoichiometry1080
left: SmallMolecule548
left: SmallMolecule433
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule551

UnificationXref14893
type: UnificationXref
id: 6266674
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266674

UnificationXref14892
type: UnificationXref
id: 6266673
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266673

phagocytic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref5771

Stoichiometry1903
type: Stoichiometry
physical entity: Protein6323
stoichiometric coefficient: 1.0

UnificationXref14898
type: UnificationXref
id: CHEBI:50648
db: ChEBI

Stoichiometry1904
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

UnificationXref14899
type: UnificationXref
id: 5362520
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5362520

Stoichiometry1901
type: Stoichiometry
physical entity: Protein6319
stoichiometric coefficient: 1.0

UnificationXref14896
type: UnificationXref
id: 6266678
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266678

Stoichiometry1902
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

UnificationXref14897
type: UnificationXref
id: REACT_226327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226327.2

Stoichiometry1907
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Stoichiometry1908
type: Stoichiometry
physical entity: SmallMolecule294
stoichiometric coefficient: 1.0

synaptic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref4411

Stoichiometry1905
type: Stoichiometry
physical entity: SmallMolecule294
stoichiometric coefficient: 1.0

Stoichiometry1906
type: Stoichiometry
physical entity: Protein6326
stoichiometric coefficient: 1.0

Stoichiometry1900
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

UnificationXref14880
type: UnificationXref
id: 6266661
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266661

secretory granule membrane
type: CellularLocationVocabulary
xref: UnificationXref4848

UnificationXref14882
type: UnificationXref
id: 6266663
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266663

UnificationXref14881
type: UnificationXref
id: 6266662
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266662

UnificationXref14884
type: UnificationXref
id: 6266665
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266665

UnificationXref14883
type: UnificationXref
id: 6266664
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266664

Stoichiometry1912
type: Stoichiometry
physical entity: PhysicalEntity215
stoichiometric coefficient: 1.0

UnificationXref14885
type: UnificationXref
id: 6266666
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266666

Stoichiometry1913
type: Stoichiometry
physical entity: SmallMolecule3
stoichiometric coefficient: 2.0

UnificationXref14886
type: UnificationXref
id: 6266667
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266667

Stoichiometry1914
type: Stoichiometry
physical entity: Protein6354
stoichiometric coefficient: 2.0

UnificationXref14887
type: UnificationXref
id: 6266668
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266668

Stoichiometry1915
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 2.0

UnificationXref14888
type: UnificationXref
id: 6266669
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266669

Stoichiometry1916
type: Stoichiometry
physical entity: Protein6358
stoichiometric coefficient: 2.0

UnificationXref14889
type: UnificationXref
id: 6266670
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266670

Golgi-associated vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref289

Stoichiometry1917
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Stoichiometry1918
type: Stoichiometry
physical entity: Protein6362
stoichiometric coefficient: 1.0

Stoichiometry1919
type: Stoichiometry
physical entity: SmallMolecule1278
stoichiometric coefficient: 2.0

Stoichiometry1910
type: Stoichiometry
physical entity: Complex272
stoichiometric coefficient: 1.0

Stoichiometry1911
type: Stoichiometry
physical entity: Protein6330
stoichiometric coefficient: 1.0

1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence766
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.4
xref: UnificationXref8871
xref: UnificationXref8870
left: Water
left: SmallMolecule531
display name: Conversion of Phosphatidic Acid to Diacylglycerol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule532

lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence765
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
name: 1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
xref: UnificationXref8857
xref: UnificationXref8858
left: SmallMolecule528
left: SmallMolecule529
display name: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule530
right: coenzyme A

Conversion of glycerol-3-phosphate to lysophosphatidic acid
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence764
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.15
name: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]
xref: UnificationXref8814
xref: UnificationXref8815
left: SmallMolecule528
left: SmallMolecule527
display name: G3P is acylated to 1-acyl LPA by AGPAT6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule529
right: coenzyme A

Conversion of Glycerol to Glycerol-3-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence763
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.30
xref: UnificationXref8805
xref: UnificationXref8804
left: SmallMolecule511
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule527

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence762
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.8
xref: UnificationXref8796
xref: UnificationXref8797
left: NADH
left: proton
left: SmallMolecule388
display name: DHAP is converted to G3P by GPD1/GPD1L
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: DPN
right: SmallMolecule527

trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence759
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8781
xref: UnificationXref8782
left: proton
left: NADPH
left: SmallMolecule525
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule526

3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence758
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.211
xref: UnificationXref8770
xref: UnificationXref8771
left: proton
left: NADPH
left: SmallMolecule518
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule524

http://identifiers.org/pubmed/11459976
type: PublicationXref
id: 11459976
author: Bell, SP
author: Klemm, RD
db: Pubmed
title: ATP bound to the origin recognition complex is important for preRC formation.
source: Proc Natl Acad Sci U S A 98:8361-7
year: 2001

arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence757
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8751
xref: UnificationXref8752
left: SmallMolecule522
left: SmallMolecule517
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule523
right: coenzyme A

UnificationXref14873
type: UnificationXref
id: 6266654
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266654

UnificationXref14872
type: UnificationXref
id: 6266653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266653

UnificationXref14871
type: UnificationXref
id: 6266652
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266652

UnificationXref14870
type: UnificationXref
id: 6266651
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266651

UnificationXref14878
type: UnificationXref
id: 6266659
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266659

UnificationXref14879
type: UnificationXref
id: 6266660
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266660

UnificationXref14876
type: UnificationXref
id: 6266657
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266657

UnificationXref14877
type: UnificationXref
id: 6266658
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266658

UnificationXref14874
type: UnificationXref
id: 6266655
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266655

UnificationXref14875
type: UnificationXref
id: 6266656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266656

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence767
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.20
xref: UnificationXref8887
xref: UnificationXref8886
left: SmallMolecule533
left: SmallMolecule532
display name: Conversion of Diacylglycerol to Triacylglycerol [DGAT1]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule534
right: coenzyme A

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence768
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.20
xref: UnificationXref8890
xref: UnificationXref8891
left: SmallMolecule533
left: SmallMolecule532
display name: Conversion of Diacylglycerol to Triacylglycerol [DGAT2]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule534
right: coenzyme A

Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence783
conversion direction: LEFT_TO_RIGHT
EC number: 1.6
xref: UnificationXref8982
xref: UnificationXref8981
xref: RelationshipXref616
left: H+
left: NADH
left: SmallMolecule549
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule550
right: DPN

(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence780
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref8966
xref: UnificationXref8967
left: SmallMolecule547
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: NADH
right: SmallMolecule548

acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence787
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.3.10
xref: UnificationXref9010
xref: UnificationXref9009
left: SmallMolecule551
left: SmallMolecule548
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule552
right: SmallMolecule433

2 acetyl-CoA <=> acetoacetyl-CoA + CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence786
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.9
xref: UnificationXref8995
xref: UnificationXref8996
participant stoichiometry: Stoichiometry1077
left: SmallMolecule551
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule548
right: SmallMolecule433

(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence774
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref8937
xref: UnificationXref8936
left: SmallMolecule541
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule542
right: NADH

(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence772
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref8926
xref: UnificationXref8927
left: DPN
left: SmallMolecule539
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: SmallMolecule540
right: NADH

(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence778
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref8956
xref: UnificationXref8957
left: SmallMolecule545
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: NADH
right: SmallMolecule546

(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence776
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref8947
xref: UnificationXref8946
left: SmallMolecule543
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H+
right: NADH
right: SmallMolecule544

UnificationXref14860
type: UnificationXref
id: 6266641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266641

UnificationXref14862
type: UnificationXref
id: 6266643
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266643

Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence770
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref8913
xref: UnificationXref8914
left: SmallMolecule535
left: SmallMolecule536
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule537
right: SmallMolecule538

UnificationXref14861
type: UnificationXref
id: 6266642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266642

UnificationXref14867
type: UnificationXref
id: 6266648
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266648

UnificationXref14868
type: UnificationXref
id: 6266649
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266649

UnificationXref14869
type: UnificationXref
id: 6266650
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266650

UnificationXref14863
type: UnificationXref
id: 6266644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266644

UnificationXref14864
type: UnificationXref
id: 6266645
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266645

UnificationXref14865
type: UnificationXref
id: 6266646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266646

UnificationXref14866
type: UnificationXref
id: 6266647
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266647

HMG CoA => acetoacetic acid + acetyl CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence788
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.3.4
xref: UnificationXref9028
xref: UnificationXref9029
left: SmallMolecule552
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule551
right: SmallMolecule553

Processing and activation of SUMO
type: Pathway
data source: Provenance1
pathway component: REACT 204485.2
pathway component: REACT 224715.2
pathway component: REACT 207517.2
evidence: Evidence1865
xref: RelationshipXref1588
xref: UnificationXref20001
xref: UnificationXref20000
pathway order: PathwayStep1843
pathway order: PathwayStep1835
pathway order: PathwayStep1839
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/22178396
type: PublicationXref
id: 22178396
author: Anderton, Emma
author: Shinkai, Y
author: Kuninaka, Shinji
author: Saya, H
author: Imai, Yoshinori
author: Peters, Gordon
author: Hara, Eiji
author: Yamakoshi, Kimi
author: Yoshimoto, Shin
author: Takeuchi, Takashi
author: Ohtani, Naoko
author: Takahashi, Akiko
author: Hori, Satoshi
author: Tachibana, M
db: Pubmed
title: DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
source: Mol. Cell 45:123-31
year: 2012

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

http://identifiers.org/pubmed/11459989
type: PublicationXref
id: 11459989
author: Paulusma, C
author: Wyman, C
author: Kanaar, R
author: Ristic, D
db: Pubmed
title: The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.
source: Proc Natl Acad Sci U S A 98:8454-60
year: 2001

(1R-cis)-2-amino-1,9-dihydro-9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one
type: SmallMoleculeReference
name: (-)-carbovir
name: carbovir
name: CBV
name: 2-amino-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-9H-purin-6-ol
name: (-)-carbovir [ChEBI:421843]
xref: UnificationXref15675

http://identifiers.org/pubmed/9856482
type: PublicationXref
id: 9856482
author: Schnetkamp, PP
author: Tucker, JE
author: Walter, MA
author: Friedman, JS
author: Winkfein, RJ
author: Murthy, SK
author: Demetrick, DJ
db: Pubmed
title: Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger
source: Hum Genet 103:411-4
year: 1998

http://identifiers.org/pubmed/7506871
type: PublicationXref
id: 7506871
author: Hübner, S
author: Appelhans, H
author: Wagner, S
author: Drenckhahn, D
author: Kollert-Jöns, A
db: Pubmed
title: Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
source: Am J Physiol 265:F813-21
year: 1993

Stoichiometry1896
type: Stoichiometry
physical entity: Protein6319
stoichiometric coefficient: 1.0

Stoichiometry1895
type: Stoichiometry
physical entity: PhysicalEntity211
stoichiometric coefficient: 1.0

Stoichiometry1894
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

Stoichiometry1893
type: Stoichiometry
physical entity: PhysicalEntity212
stoichiometric coefficient: 1.0

Stoichiometry1899
type: Stoichiometry
physical entity: SmallMolecule868
stoichiometric coefficient: 1.0

Stoichiometry1898
type: Stoichiometry
physical entity: Protein6323
stoichiometric coefficient: 1.0

Stoichiometry1897
type: Stoichiometry
physical entity: SmallMolecule868
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/19373259
type: PublicationXref
id: 19373259
author: Pauli, Silke
author: Koch, HG
author: Linnebank, Michael
author: Häberle, Johannes
author: Berning, Christoph
db: Pubmed
title: TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations
source: J. Hum. Genet. 54:331-4
year: 2009

MVB Vesicle Formation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence22
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref438
xref: UnificationXref439
left: Complex17
left: Complex20
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex19
right: Complex21

14-3-3 binds p-5S,T642-AS160 (TBC1D4)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence24
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref490
xref: UnificationXref491
left: Complex22
left: Complex25
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex26

Golgi vesicle lattice disassociation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence16
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref312
xref: UnificationXref311
left: PhysicalEntity6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein156
right: Complex13

trans-Golgi Network Coat Activation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence19
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref318
xref: UnificationXref317
left: SmallMolecule1
left: Complex16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule2
right: Complex12

AMPK-alpha2 phosphorylates TBC1D1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence25
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11
xref: UnificationXref542
xref: UnificationXref543
left: Protein269
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: Protein272

14-3-3 Binds p-S237-TBC1D1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence26
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref545
xref: UnificationXref546
left: Complex22
left: Protein272
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex33

http://identifiers.org/pubmed/20198122
type: PublicationXref
id: 20198122
author: La Cava, Antonio
author: Matarese, Giuseppe
author: Lam, Queenie Lai Kwan
author: Lu, Liwei
author: Iikuni, Noriko
db: Pubmed
title: Leptin and Inflammation
source: Curr Immunol Rev 4:70-79
year: 2008

Hydrolysis of Arf1-GTP to Arf1-GDP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence14
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref294
xref: UnificationXref295
left: Complex15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: PhysicalEntity7

Diffusion of inactive Arf1-GDP from membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence15
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref309
xref: UnificationXref310
left: PhysicalEntity7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity5
right: Complex16

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence12
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref287
xref: UnificationXref286
left: Complex15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity4

Sculpting and pinching-off of Golgi vessicle
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence13
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref292
xref: UnificationXref291
left: PhysicalEntity5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity6

Stoichiometry1883
type: Stoichiometry
physical entity: SmallMolecule868
stoichiometric coefficient: 1.0

Stoichiometry1882
type: Stoichiometry
physical entity: Protein6256
stoichiometric coefficient: 1.0

Stoichiometry1885
type: Stoichiometry
physical entity: Protein6256
stoichiometric coefficient: 1.0

Stoichiometry1884
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

Stoichiometry1887
type: Stoichiometry
physical entity: SmallMolecule868
stoichiometric coefficient: 1.0

Stoichiometry1886
type: Stoichiometry
physical entity: PhysicalEntity211
stoichiometric coefficient: 1.0

Stoichiometry1889
type: Stoichiometry
physical entity: Complex826
stoichiometric coefficient: 1.0

Stoichiometry1888
type: Stoichiometry
physical entity: Protein2761
stoichiometric coefficient: 1.0

Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence35
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.145
xref: UnificationXref666
xref: UnificationXref665
left: Pregnenolone
left: DPN
display name: Pregnenolone + NAD+ => pregn-5-ene-3,20-dione + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: pregn-5-ene-3,20-dione

Pregn-5-ene-3,20-dione isomerizes to progesterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence36
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.3.1
xref: UnificationXref671
xref: UnificationXref670
left: pregn-5-ene-3,20-dione
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Progesterone

DHA isomerizes to 4-Androstene3,17-dione
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence38
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.3.1
xref: UnificationXref681
xref: UnificationXref680
left: dehydroepiandrosterone
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: 4-Androstene-3, 17-dione

Reduction of androstenedione to testosterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence39
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.239
xref: UnificationXref711
xref: UnificationXref712
left: proton
left: 4-Androstene-3, 17-dione
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Testosterone
right: NADP+

transport vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref3556

Testosterone is converted to 5-alpha-dihydroxytestosterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence40
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.99.5
xref: UnificationXref731
xref: UnificationXref732
left: Testosterone
left: proton
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 5-alpha-dihydrotestosterone
right: NADP+

cytoplasmic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref462

RAB8A,10,13,14 exchange GDP for GTP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence27
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref574
xref: UnificationXref575
left: Complex34
left: SmallMolecule9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex35
right: SmallMolecule8

RAB8A,10,13,14 hydrolyze GTP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence28
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.5.1
EC number: 3.6.5.3
EC number: 3.6.5.2
EC number: 3.6.5.4
xref: UnificationXref576
xref: UnificationXref577
left: Complex35
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex34

Stoichiometry1890
type: Stoichiometry
physical entity: Protein6257
stoichiometric coefficient: 1.0

17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence31
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.145
xref: UnificationXref610
xref: UnificationXref611
left: 17alpha-hydroxypregnenolone
left: DPN
display name: 17-hydroxypregnenolone + NAD+ => pregn-5-ene-3,20-dione-17-ol + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: pregn-5-ene-3,20-dione-17-ol
right: proton

Stoichiometry1891
type: Stoichiometry
physical entity: Complex826
stoichiometric coefficient: 1.0

Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence32
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.3.1
xref: UnificationXref615
xref: UnificationXref616
left: pregn-5-ene-3,20-dione-17-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 17alpha-hydroxyprogesterone

Stoichiometry1892
type: Stoichiometry
physical entity: Complex826
stoichiometric coefficient: 1.0

cortisol + NADP+ => cortisone + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence33
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref656
xref: UnificationXref655
left: Cortisol
left: NADP+
display name: Oxidation of cortisol to yield cortisone
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: Cortisone
right: NADPH

UnificationXref14924
type: UnificationXref
id: 6266465
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266465

UnificationXref14925
type: UnificationXref
id: 6266467
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266467

UnificationXref14922
type: UnificationXref
id: 6266459
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266459

UnificationXref14923
type: UnificationXref
id: 6266462
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266462

UnificationXref14920
type: UnificationXref
id: 6266454
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266454

UnificationXref14921
type: UnificationXref
id: 6266456
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266456

Stoichiometry1879
type: Stoichiometry
physical entity: SmallMolecule2
stoichiometric coefficient: 1.0

Stoichiometry1877
type: Stoichiometry
physical entity: PhysicalEntity207
stoichiometric coefficient: 1.0

Stoichiometry1878
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry1875
type: Stoichiometry
physical entity: SmallMolecule868
stoichiometric coefficient: 1.0

Stoichiometry1876
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

Stoichiometry1873
type: Stoichiometry
physical entity: SmallMolecule1
stoichiometric coefficient: 1.0

UnificationXref14928
type: UnificationXref
id: 6266473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266473

Stoichiometry1874
type: Stoichiometry
physical entity: PhysicalEntity207
stoichiometric coefficient: 1.0

UnificationXref14929
type: UnificationXref
id: 6266476
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266476

Stoichiometry1871
type: Stoichiometry
physical entity: Protein6110
stoichiometric coefficient: 1.0

UnificationXref14926
type: UnificationXref
id: 6266469
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266469

Stoichiometry1872
type: Stoichiometry
physical entity: Protein6110
stoichiometric coefficient: 1.0

UnificationXref14927
type: UnificationXref
id: 6266471
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266471

Stoichiometry1881
type: Stoichiometry
physical entity: PhysicalEntity209
stoichiometric coefficient: 1.0

CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence52
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.22
xref: UnificationXref916
xref: UnificationXref917
participant stoichiometry: Stoichiometry108
participant stoichiometry: Stoichiometry119
left: Complex48
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex48
right: SmallMolecule6

Stoichiometry1880
type: Stoichiometry
physical entity: Complex823
stoichiometric coefficient: 1.0

1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence48
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.4
xref: UnificationXref831
xref: UnificationXref830
left: 1,2-diacyl-glycerol 3-phosphate
left: Water
display name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 1,2-diacyl-sn-glycerol

CDK1 phosphorylates LPIN
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence47
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.22
xref: UnificationXref820
xref: UnificationXref819
left: PhysicalEntity17
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity18
right: Adenosine 5'-diphosphate

PLK1 hyperphosphorylates Condensin II complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence45
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref804
xref: UnificationXref805
left: Complex45
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex46
right: Adenosine 5'-diphosphate

CDK1 phosphorylates condensin II subunit NCAPD3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence44
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.22
xref: UnificationXref792
xref: UnificationXref791
left: Adenosine 5'-triphosphate
left: Complex40
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex42
right: Adenosine 5'-diphosphate

RB1 binds condensin II
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence43
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref766
xref: UnificationXref767
left: Complex38
left: Protein363
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex39

CDK1 phosphorylates condensin I
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence57
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.11.22
xref: UnificationXref1095
xref: UnificationXref1094
participant stoichiometry: Stoichiometry162
participant stoichiometry: Stoichiometry163
left: Complex58
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex65
right: SmallMolecule6

Dephosphorylation of CK2-modified condensin I
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence56
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.16
xref: UnificationXref1083
xref: UnificationXref1082
participant stoichiometry: Stoichiometry160
participant stoichiometry: Stoichiometry161
left: Water
left: Complex59
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: Complex58

CK2 phosphorylates condensin I subunits
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence55
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1077
xref: UnificationXref1076
participant stoichiometry: Stoichiometry148
participant stoichiometry: Stoichiometry142
left: Complex58
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex59
right: SmallMolecule6

Deacetylation of cohesin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence53
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref978
xref: UnificationXref977
participant stoichiometry: Stoichiometry124
participant stoichiometry: Stoichiometry141
left: Complex54
left: coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex56
right: Acetyl coenzyme A

UnificationXref14933
type: UnificationXref
id: 6266485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266485

UnificationXref14934
type: UnificationXref
id: 6266488
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266488

UnificationXref14935
type: UnificationXref
id: 6266490
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266490

UnificationXref14936
type: UnificationXref
id: 6266492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266492

Stoichiometry1868
type: Stoichiometry
physical entity: Protein1119
stoichiometric coefficient: 1.0

Stoichiometry1869
type: Stoichiometry
physical entity: PhysicalEntity45
stoichiometric coefficient: 1.0

UnificationXref14930
type: UnificationXref
id: 6266478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266478

UnificationXref14931
type: UnificationXref
id: 6266480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266480

UnificationXref14932
type: UnificationXref
id: 6266483
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266483

Stoichiometry1864
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 2.0

Stoichiometry1865
type: Stoichiometry
physical entity: Protein2815
stoichiometric coefficient: 1.0

Stoichiometry1866
type: Stoichiometry
physical entity: SmallMolecule1272
stoichiometric coefficient: 1.0

Stoichiometry1867
type: Stoichiometry
physical entity: Protein6094
stoichiometric coefficient: 1.0

Stoichiometry1860
type: Stoichiometry
physical entity: Protein275
stoichiometric coefficient: 1.0

UnificationXref14937
type: UnificationXref
id: 6266494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266494

Stoichiometry1861
type: Stoichiometry
physical entity: Complex813
stoichiometric coefficient: 1.0

UnificationXref14938
type: UnificationXref
id: 6266497
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266497

Stoichiometry1862
type: Stoichiometry
physical entity: SmallMolecule7
stoichiometric coefficient: 1.0

UnificationXref14939
type: UnificationXref
id: 6266500
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266500

Stoichiometry1863
type: Stoichiometry
physical entity: SmallMolecule5
stoichiometric coefficient: 2.0

Orc3 associates with Orc2 constitutively bound at origins of replication
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence70
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1570
xref: UnificationXref1569
left: Protein822
left: Complex77
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex78

Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence66
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1546
xref: UnificationXref1545
participant stoichiometry: Stoichiometry240
participant stoichiometry: Stoichiometry237
left: Complex71
left: Complex73
left: PhysicalEntity26
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex74

Stoichiometry1870
type: Stoichiometry
physical entity: SmallMolecule1273
stoichiometric coefficient: 1.0

Orc4 associates with Orc5:Orc3:Orc2:origin complexes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence72
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1586
xref: UnificationXref1587
left: Complex79
left: Protein834
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex80

Orc5 associates with Orc3:Orc2:origin complexes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence71
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1582
xref: UnificationXref1581
left: Protein829
left: Complex78
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex79

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence60
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: RelationshipXref50
xref: UnificationXref1220
xref: UnificationXref1221
participant stoichiometry: Stoichiometry185
left: Complex66
left: PhysicalEntity24
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex66

Autocleavage of ESPL1 (Separase)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence62
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1480
xref: UnificationXref1479
left: Protein766
display name: Autocleavage of Separin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex70

Degradation of multiubiquitinated Securin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence61
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1462
xref: UnificationXref1463
participant stoichiometry: Stoichiometry186
left: Complex66
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex67
right: PhysicalEntity24

Association of MCM8 with ORC:origin complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence75
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1603
xref: UnificationXref1604
left: Complex82
left: Protein836
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex83

Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence73
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1593
xref: UnificationXref1592
left: Complex81
left: Protein835
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex82

CDC6 association with ORC:origin complexes mediated by MCM8
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence77
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1653
xref: UnificationXref1652
left: Protein839
left: Complex83
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex85

Stoichiometry1859
type: Stoichiometry
physical entity: PhysicalEntity12
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

Stoichiometry1857
type: Stoichiometry
physical entity: Protein275
stoichiometric coefficient: 1.0

Stoichiometry1858
type: Stoichiometry
physical entity: PhysicalEntity204
stoichiometric coefficient: 1.0

UnificationXref14902
type: UnificationXref
id: 5362524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5362524

UnificationXref14903
type: UnificationXref
id: REACT_229200
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229200.1

UnificationXref14900
type: UnificationXref
id: REACT_228543
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228543.1

UnificationXref14901
type: UnificationXref
id: CHEBI:63802
db: ChEBI

Stoichiometry1851
type: Stoichiometry
physical entity: SmallMolecule5
stoichiometric coefficient: 5.0

UnificationXref14906
type: UnificationXref
id: 6266415
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266415

Stoichiometry1852
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 5.0

UnificationXref14907
type: UnificationXref
id: 6266418
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266418

UnificationXref14904
type: UnificationXref
id: 6266409
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266409

Stoichiometry1850
type: Stoichiometry
physical entity: Protein6048
stoichiometric coefficient: 1.0

UnificationXref14905
type: UnificationXref
id: 6266412
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266412

Stoichiometry1855
type: Stoichiometry
physical entity: PhysicalEntity203
stoichiometric coefficient: 1.0

Stoichiometry1856
type: Stoichiometry
physical entity: PhysicalEntity12
stoichiometric coefficient: 1.0

Ubiquitinated Cdc6 is degraded by the proteasome
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence95
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1814
xref: UnificationXref1813
left: ubiquitinated Cdc6 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity24

Stoichiometry1853
type: Stoichiometry
physical entity: SmallMolecule5
stoichiometric coefficient: 3.0

UnificationXref14908
type: UnificationXref
id: 6266421
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266421

Stoichiometry1854
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 3.0

UnificationXref14909
type: UnificationXref
id: 6266424
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266424

DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence83
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1721
xref: UnificationXref1720
left: Complex96
left: Complex95
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex97

Cdc45 associates with the pre-replicative complex at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence82
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1706
xref: UnificationXref1707
left: Complex90
left: Protein878
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex95

Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence81
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1685
xref: UnificationXref1684
left: Protein877
left: Complex88
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex89

Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence79
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1677
xref: UnificationXref1678
left: Complex86
left: Complex87
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex88

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence91
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.7
xref: UnificationXref1796
xref: UnificationXref1797
left: Deoxythymidine 5'-triphosphate
left: deoxycytidine 5'-triphosphate
left: 2'-deoxyadenosine 5'-triphosphate
left: 2'-deoxyguanosine 5'-triphosphate
left: RNA primer:origin duplex:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence90
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.6
xref: UnificationXref1779
xref: UnificationXref1780
left: NTP
left: DNA polymerase alpha:primase:DNA polymerase alpha:origin complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex99
right: RNA primer:origin duplex:DNA polymerase alpha:primase complex (name copied from entity in Homo sapiens)

DNA polymerase epsilon binds at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence85
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1757
xref: UnificationXref1756
left: PhysicalEntity28
left: Complex99
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex98

DNA polymerase alpha:primase binds at the origin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence84
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1754
xref: UnificationXref1753
left: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
left: Complex98
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: DNA polymerase alpha:primase:DNA polymerase alpha:origin complex (name copied from entity in Homo sapiens)

Phosphorylated Cdc6 is exported from the nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence94
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1807
xref: UnificationXref1806
left: Protein839
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein908

Cdc6 protein is phosphorylated by CDK
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence93
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1800
xref: UnificationXref1801
left: Protein839
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein839
right: Adenosine 5'-diphosphate

UniProt:A2ZZV6
type: ProteinReference
xref: UnificationXref20513
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1846
type: Stoichiometry
physical entity: PhysicalEntity11
stoichiometric coefficient: 1.0

Stoichiometry1847
type: Stoichiometry
physical entity: Complex812
stoichiometric coefficient: 1.0

Stoichiometry1848
type: Stoichiometry
physical entity: Protein6043
stoichiometric coefficient: 1.0

Stoichiometry1849
type: Stoichiometry
physical entity: Protein6047
stoichiometric coefficient: 1.0

UnificationXref14910
type: UnificationXref
id: 6266426
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266426

UnificationXref14911
type: UnificationXref
id: 6266429
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266429

UnificationXref14912
type: UnificationXref
id: 6266432
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266432

UnificationXref14913
type: UnificationXref
id: 6266435
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266435

UnificationXref14914
type: UnificationXref
id: 6266438
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266438

UnificationXref14915
type: UnificationXref
id: 6266441
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266441

UnificationXref14916
type: UnificationXref
id: 6266443
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266443

Stoichiometry1840
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

UnificationXref14917
type: UnificationXref
id: 6266445
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266445

Stoichiometry1841
type: Stoichiometry
physical entity: Complex807
stoichiometric coefficient: 1.0

UnificationXref14918
type: UnificationXref
id: 6266448
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266448

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

Stoichiometry1842
type: Stoichiometry
physical entity: PhysicalEntity202
stoichiometric coefficient: 1.0

UnificationXref14919
type: UnificationXref
id: 6266451
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266451

Stoichiometry1843
type: Stoichiometry
physical entity: SmallMolecule5
stoichiometric coefficient: 2.0

Stoichiometry1844
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 2.0

Formation of Okazaki fragments
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence110
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.7
xref: UnificationXref1900
xref: UnificationXref1899
left: Processive complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex:Okazaki fragment complex (name copied from entity in Homo sapiens)

Stoichiometry1845
type: Stoichiometry
physical entity: SmallMolecule1
stoichiometric coefficient: 1.0

Formation of the Flap Intermediate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence111
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1905
xref: UnificationXref1904
left: Processive complex:Okazaki fragment complex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex:Okazaki fragment:Flap (name copied from entity in Homo sapiens)

MCM2-7 mediated fork unwinding
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence99
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1826
xref: UnificationXref1827
left: PhysicalEntity32
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity33

Mcm4,6,7 trimer forms and associates with the replication fork
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence97
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1819
xref: UnificationXref1818
left: Complex87
display name: Rearrangement and mobilization of Mcm2-7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein876
right: Protein874
right: Protein875
right: Mcm4,6,7 complex (name copied from entity in Homo sapiens)

Multiple proteins are localized at replication fork
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence101
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1844
xref: UnificationXref1843
left: PhysicalEntity32
left: Protein878
left: GINS complex (name copied from entity in Homo sapiens)
left: Complex87
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Unwinding complex at replication fork (name copied from entity in Homo sapiens)

MCM8 mediated fork unwinding
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence100
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1829
xref: UnificationXref1828
left: PhysicalEntity32
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity33

Loading of PCNA - Sliding Clamp Formation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence104
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1871
xref: UnificationXref1870
left: PCNA homotrimer (name copied from entity in Homo sapiens)
left: RFC Heteropentamer:RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer (name copied from entity in Homo sapiens)
right: Adenosine 5'-diphosphate

RFC binding displaces Pol Alpha
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence103
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1865
xref: UnificationXref1864
left: RFC Heteropentamer (name copied from entity in Homo sapiens)
left: RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RFC Heteropentamer:RNA primer-DNA primer:origin duplex (name copied from entity in Homo sapiens)

Formation of Processive Complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence106
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1889
xref: UnificationXref1888
left: RNA primer-DNA primer:origin duplex:PCNA (name copied from entity in Homo sapiens)
left: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex (name copied from entity in Homo sapiens)

RFC dissociates after sliding clamp formation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence105
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1874
xref: UnificationXref1873
left: RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: RFC Heteropentamer (name copied from entity in Homo sapiens)
right: RNA primer-DNA primer:origin duplex:PCNA (name copied from entity in Homo sapiens)

Processive synthesis on the leading strand
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence108
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref1892
xref: UnificationXref1893
left: RNA primer-DNA primer:origin duplex:PCNA (name copied from entity in Homo sapiens)
left: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Processive complex (name copied from entity in Homo sapiens)

protoheme
type: SmallMolecule
entity reference: CHEBI_17627
data source: Provenance1
xref: UnificationXref3577
xref: UnificationXref3576
cellular location: GO_0005759
comment: Reactome DB_ID: 189444
display name: heme

Phosphate
type: SmallMolecule
entity reference: CHEBI_18367
data source: Provenance1
name: Orthophosphate
xref: UnificationXref3579
xref: UnificationXref3578
cellular location: GO_0005759
comment: Reactome DB_ID: 113548
display name: Pi

heme (ferrous)
type: SmallMolecule
entity reference: CHEBI_17627
data source: Provenance1
xref: UnificationXref3580
xref: UnificationXref3581
cellular location: GO_0005829
comment: Reactome DB_ID: 71185
display name: heme

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI_16761
data source: Provenance1
xref: UnificationXref3582
xref: UnificationXref3583
cellular location: GO_0005759
comment: Reactome DB_ID: 113581
display name: ADP

porphyrin
type: SmallMolecule
entity reference: CHEBI 8337
data source: Provenance1
xref: UnificationXref3592
xref: UnificationXref3593
cellular location: GO_0005829
comment: Reactome DB_ID: 1369066

porphyrin
type: SmallMolecule
entity reference: CHEBI 8337
data source: Provenance1
xref: UnificationXref3594
xref: UnificationXref3595
cellular location: GO_0005759
comment: Reactome DB_ID: 1369027

organic anion
type: SmallMolecule
entity reference: CHEBI_25696
data source: Provenance1
xref: UnificationXref3606
xref: UnificationXref3605
cellular location: GO_0005829
comment: Reactome DB_ID: 1454930

organic anion
type: SmallMolecule
entity reference: CHEBI_25696
data source: Provenance1
xref: UnificationXref3608
xref: UnificationXref3607
cellular location: GO_0005576
comment: Reactome DB_ID: 1454919

UnificationXref10244
type: UnificationXref
id: 6275244
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275244

UnificationXref10243
type: UnificationXref
id: B9F080
db: UniProt

UnificationXref10246
type: UnificationXref
id: 6275247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275247

http://identifiers.org/pubmed/23599745
type: PublicationXref
id: 23599745
author: Hamid, Abdu Selim
author: Tesfamariam, Isaias Goitom
author: Zhang, Zhen Gui
author: Zhang, Yucheng
db: Pubmed
title: Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention
source: Oncol Lett 5:1087-1092
year: 2013

UnificationXref10245
type: UnificationXref
id: OS04T0394100-00
db: Ensembl

UnificationXref10248
type: UnificationXref
id: 6275250
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275250

UnificationXref10247
type: UnificationXref
id: 6275248
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275248

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI_15422
data source: Provenance1
xref: UnificationXref3574
xref: UnificationXref3573
cellular location: GO_0005759
comment: Reactome DB_ID: 113593
display name: ATP

UnificationXref10249
type: UnificationXref
id: REACT_197954
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197954.3

Recycling of bile acids and salts
type: Pathway
data source: Provenance1
pathway component: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
evidence: Evidence878
xref: RelationshipXref710
xref: UnificationXref9973
xref: UnificationXref9974
pathway order: PathwayStep856
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10240
type: UnificationXref
id: 6275239
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275239

UnificationXref10241
type: UnificationXref
id: OS08T0535700-00
db: Ensembl

UnificationXref10242
type: UnificationXref
id: 6275242
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275242

phys-ent-participant2619
type: SmallMolecule
entity reference: CHEBI_35703
data source: Provenance1
xref: UnificationXref3707
xref: UnificationXref3706
cellular location: GO_0005829
comment: Reactome DB_ID: 1131652
display name: a xenobiotic

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

cholesterol and phytosterols
type: SmallMolecule
data source: Provenance1
member physical entity: cholesterol
member physical entity: phytosterols
xref: UnificationXref3462
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6266962
display name: sterols

cholesterol
type: SmallMolecule
entity reference: CHEBI_16113
data source: Provenance1
xref: UnificationXref3458
xref: UnificationXref3457
cellular location: GO_0005829
comment: Reactome DB_ID: 176478
display name: CHOL

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI_15904
data source: Provenance1
xref: UnificationXref3450
xref: UnificationXref3449
cellular location: GO_0005829
comment: Reactome DB_ID: 382577
display name: LCFA

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI_15904
data source: Provenance1
xref: UnificationXref3453
xref: UnificationXref3452
cellular location: GO_0005782
comment: Reactome DB_ID: 382571
display name: LFCA

cholesterol
type: SmallMolecule
entity reference: CHEBI_16113
data source: Provenance1
xref: UnificationXref3463
xref: UnificationXref3464
cellular location: GO_0005576
comment: Reactome DB_ID: 171149
display name: CHOL

phytosterols
type: SmallMolecule
entity reference: CHEBI_26125
data source: Provenance1
xref: UnificationXref3465
xref: UnificationXref3466
cellular location: GO_0005576
comment: Reactome DB_ID: 265546

phytosterols
type: SmallMolecule
entity reference: CHEBI_26125
data source: Provenance1
xref: UnificationXref3461
xref: UnificationXref3460
cellular location: GO_0005829
comment: Reactome DB_ID: 265525

cholesterol and phytosterols
type: SmallMolecule
data source: Provenance1
member physical entity: cholesterol
member physical entity: phytosterols
xref: UnificationXref3467
cellular location: GO_0005576
comment: Reactome DB_ID: 6266963
comment: Converted from EntitySet in Reactome
display name: sterols

UnificationXref10257
type: UnificationXref
id: REACT_238077
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238077.1

UnificationXref10256
type: UnificationXref
id: 6275176
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275176

UnificationXref10255
type: UnificationXref
id: 6275174
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275174

UnificationXref10254
type: UnificationXref
id: REACT_123890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123890.1

UnificationXref10259
type: UnificationXref
id: REACT_175205
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175205.3

UnificationXref10258
type: UnificationXref
id: 6275333
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275333

UnificationXref10252
type: UnificationXref
id: CHEBI:36700
db: ChEBI

UnificationXref10253
type: UnificationXref
id: 1524071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524071

UnificationXref10250
type: UnificationXref
id: 6280020
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280020

UnificationXref10251
type: UnificationXref
id: REACT_216085
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_216085.2

cholesterol
type: SmallMolecule
entity reference: CHEBI_16113
data source: Provenance1
xref: UnificationXref3559
xref: UnificationXref3560
cellular location: GO_0005886
comment: Reactome DB_ID: 171095

cholesterol
type: SmallMolecule
entity reference: CHEBI_16113
data source: Provenance1
xref: UnificationXref3558
xref: UnificationXref3557
cellular location: transport vesicle membrane
comment: Reactome DB_ID: 216762

http://identifiers.org/pubmed/7596435
type: PublicationXref
id: 7596435
author: Rossant, J
author: Shalaby, F
author: Gertsenstein, M
author: Schuh, A C
author: Yamaguchi, T P
author: Breitman, M L
author: Wu, X F
db: Pubmed
title: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
source: Nature 376:62-6
year: 1995

H+
type: SmallMolecule
entity reference: CHEBI_15378
data source: Provenance1
xref: UnificationXref3250
xref: UnificationXref3251
cellular location: GO_0005759
comment: Reactome DB_ID: 113529

5-Hydroxyindole acetic acid
type: SmallMolecule
entity reference: CHEBI_27823
data source: Provenance1
xref: UnificationXref3254
xref: UnificationXref3253
cellular location: GO_0005759
comment: Reactome DB_ID: 380593
display name: HIAA

NH4+
type: SmallMolecule
entity reference: CHEBI_28938
data source: Provenance1
xref: UnificationXref3267
xref: UnificationXref3268
cellular location: GO_0005829
comment: Reactome DB_ID: 31633

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref3270
xref: UnificationXref3269
cellular location: GO_0005829
comment: Reactome DB_ID: 29404
display name: L-Glu

NADH
type: SmallMolecule
entity reference: CHEBI_16908
data source: Provenance1
xref: UnificationXref3228
xref: UnificationXref3227
cellular location: GO_0005759
comment: Reactome DB_ID: 29362

UnificationXref10229
type: UnificationXref
id: REACT_122811
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122811.1

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI_15741
data source: Provenance1
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref3230
xref: UnificationXref3231
cellular location: GO_0005759
comment: Reactome DB_ID: 113536
display name: SUCCA

5-hydroxyindole acetaldehyde
type: SmallMolecule
entity reference: CHEBI_50157
data source: Provenance1
xref: UnificationXref3249
xref: UnificationXref3248
cellular location: GO_0005759
comment: Reactome DB_ID: 380598
display name: HIALD

UnificationXref10226
type: UnificationXref
id: REACT_186232
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186232.3

UnificationXref10225
type: UnificationXref
id: 6275075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275075

UnificationXref10228
type: UnificationXref
id: 1498729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498729

UnificationXref10227
type: UnificationXref
id: CHEBI:28936
db: ChEBI

UnificationXref10222
type: UnificationXref
id: 6275000
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275000

UnificationXref10221
type: UnificationXref
id: 6275051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275051

UnificationXref10224
type: UnificationXref
id: 6275055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275055

UnificationXref10223
type: UnificationXref
id: 6274999
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6274999

UnificationXref10220
type: UnificationXref
id: Q6EP89
db: UniProt

http://identifiers.org/pubmed/12438414
type: PublicationXref
id: 12438414
author: Michael, WM
author: Van Hatten, RA
author: Holway, AH
author: Tutter, AV
author: Khederian, AM
author: Walter, JC
db: Pubmed
title: The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.
source: J Cell Biol 159:541-7
year: 2002

Potassium
type: SmallMolecule
entity reference: CHEBI_29103
data source: Provenance1
xref: UnificationXref3344
xref: UnificationXref3343
cellular location: GO_0005829
comment: Reactome DB_ID: 29804
display name: K+

Cyclic AMP
type: SmallMolecule
entity reference: CHEBI_17489
data source: Provenance1
name: Cyclic adenylic acid
name: Adenosine 3',5'-phosphate
name: 3',5'-Cyclic AMP
xref: UnificationXref3337
xref: UnificationXref3338
cellular location: GO_0005829
comment: Reactome DB_ID: 30389
display name: cAMP

Potassium
type: SmallMolecule
entity reference: CHEBI_29103
data source: Provenance1
xref: UnificationXref3346
xref: UnificationXref3345
cellular location: GO_0005576
comment: Reactome DB_ID: 74126
display name: K+

Oxoglutaric acid
type: SmallMolecule
entity reference: CHEBI_30915
data source: Provenance1
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref3202
xref: UnificationXref3203
cellular location: GO_0005759
comment: Reactome DB_ID: 113594
display name: 2OG

Pyridoxal 5'-phosphate
type: SmallMolecule
entity reference: CHEBI_18405
data source: Provenance1
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
xref: UnificationXref3205
xref: UnificationXref3206
cellular location: GO_0005829
comment: Reactome DB_ID: 29390
display name: PXLP

gamma-aminobutyrate
type: SmallMolecule
entity reference: CHEBI_16865
data source: Provenance1
xref: UnificationXref3159
xref: UnificationXref3158
cellular location: GO_0061201
comment: Reactome DB_ID: 428571
display name: GABA

UniProt:A2ZZJ3
type: ProteinReference
xref: UnificationXref20689
organism: http://identifiers.org/taxonomy/4530

GABA
type: SmallMolecule
entity reference: CHEBI_16865
data source: Provenance1
xref: UnificationXref3200
xref: UnificationXref3199
cellular location: GO_0005759
comment: Reactome DB_ID: 916850

http://identifiers.org/pubmed/9251237
type: PublicationXref
id: 9251237
author: Gallagher, JT
author: Stringer, SE
db: Pubmed
title: Heparan sulphate
source: Int J Biochem Cell Biol 29:709-14
year: 1997

Sodium
type: SmallMolecule
entity reference: CHEBI_29101
data source: Provenance1
name: sodium ion
xref: UnificationXref3127
xref: UnificationXref3126
cellular location: GO_0005829
comment: Reactome DB_ID: 83910
display name: Na+

gamma-aminobutyrate
type: SmallMolecule
entity reference: CHEBI_16865
data source: Provenance1
xref: UnificationXref3155
xref: UnificationXref3156
cellular location: GO_0005829
comment: Reactome DB_ID: 352011
display name: GABA

UnificationXref10239
type: UnificationXref
id: Q6K9E0
db: UniProt

UnificationXref10238
type: UnificationXref
id: 6275237
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275237

UnificationXref10237
type: UnificationXref
id: Q2V8D7
db: UniProt

UnificationXref10236
type: UnificationXref
id: REACT_124601
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124601.1

UnificationXref10235
type: UnificationXref
id: 1524023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524023

UnificationXref10234
type: UnificationXref
id: CHEBI:16929
db: ChEBI

UnificationXref10233
type: UnificationXref
id: REACT_222658
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222658.2

UnificationXref10232
type: UnificationXref
id: 6280012
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280012

Arachidonic acid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 246211.1
pathway component: REACT 256153.1
pathway component: REACT 245113.1
pathway component: REACT 261475.1
pathway component: REACT 254799.1
pathway component: REACT 245795.1
pathway component: REACT 232659.1
pathway component: REACT 217794.2
pathway component: REACT 220543.2
evidence: Evidence1053
xref: RelationshipXref905
xref: UnificationXref11652
xref: UnificationXref11651
pathway order: PathwayStep1034
pathway order: PathwayStep1018
pathway order: PathwayStep1037
pathway order: PathwayStep1028
pathway order: PathwayStep1039
pathway order: PathwayStep1022
pathway order: PathwayStep1020
pathway order: PathwayStep1009
pathway order: PathwayStep1032
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10230
type: UnificationXref
id: 6275057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275057

UnificationXref10231
type: UnificationXref
id: REACT_186216
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186216.3

DPN
type: SmallMolecule
entity reference: CHEBI_15846
data source: Provenance1
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref3226
xref: UnificationXref3225
cellular location: GO_0005759
comment: Reactome DB_ID: 113526
display name: NAD

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

Water
type: SmallMolecule
entity reference: CHEBI_15377
data source: Provenance1
xref: UnificationXref3224
xref: UnificationXref3223
cellular location: GO_0005759
comment: Reactome DB_ID: 113521
display name: H2O

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glu
name: L-Glutamate
xref: UnificationXref3211
xref: UnificationXref3212
cellular location: GO_0005759
comment: Reactome DB_ID: 113552
display name: Glu

succinate semialdehyde
type: SmallMolecule
entity reference: CHEBI_16265
data source: Provenance1
xref: UnificationXref3209
xref: UnificationXref3208
cellular location: GO_0005759
comment: Reactome DB_ID: 880046
display name: SUCCSA

UnificationXref10287
type: UnificationXref
id: 1524057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524057

UnificationXref10288
type: UnificationXref
id: REACT_122825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122825.1

UnificationXref10289
type: UnificationXref
id: 429785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429785

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

http://identifiers.org/pubmed/9593755
type: PublicationXref
id: 9593755
author: Garber, Ellen A
author: Miatkowski, Konrad
author: Wang, Elizabeth A
author: Baker, Darren P
author: Bixler, Sarah A
author: Rayhorn, Paul
author: Williams, Kevin P
author: Ambrose, Christine M
author: Pepinsky, R Blake
author: Zeng, Chenhui
author: Wen, Dingyi
author: Taylor, Frederick R
author: Galdes, Alphonse
db: Pubmed
title: Identification of a palmitic acid-modified form of human Sonic hedgehog
source: J. Biol. Chem. 273:14037-45
year: 1998

UnificationXref10280
type: UnificationXref
id: 6275199
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275199

UnificationXref10282
type: UnificationXref
id: 6275201
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275201

UnificationXref10281
type: UnificationXref
id: 6275200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275200

UnificationXref10284
type: UnificationXref
id: REACT_197899
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197899.3

UnificationXref10283
type: UnificationXref
id: 6275203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275203

UnificationXref10286
type: UnificationXref
id: REACT_241221
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241221.1

UnificationXref10285
type: UnificationXref
id: 6275121
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275121

UnificationXref10298
type: UnificationXref
id: 6275135
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275135

UnificationXref10299
type: UnificationXref
id: REACT_234685
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234685.1

UnificationXref10293
type: UnificationXref
id: 6275132
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275132

UnificationXref10292
type: UnificationXref
id: REACT_121845
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121845.1

UnificationXref10291
type: UnificationXref
id: 1524074
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524074

UnificationXref10290
type: UnificationXref
id: REACT_20218
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20218.2

UnificationXref10297
type: UnificationXref
id: 6275133
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275133

UnificationXref10296
type: UnificationXref
id: 6275131
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275131

UnificationXref10295
type: UnificationXref
id: 6275130
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275130

UnificationXref10294
type: UnificationXref
id: 6275129
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275129

UnificationXref10269
type: UnificationXref
id: Q7EYE4
db: UniProt

UnificationXref10265
type: UnificationXref
id: B9F3B3
db: UniProt

UnificationXref10266
type: UnificationXref
id: 6275184
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275184

UnificationXref10267
type: UnificationXref
id: Q6H513
db: UniProt

UnificationXref10268
type: UnificationXref
id: 6275186
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275186

UniProt:E2DWX6
type: ProteinReference
xref: UnificationXref18260
organism: http://identifiers.org/taxonomy/4530

UnificationXref10262
type: UnificationXref
id: REACT_122526
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122526.1

UnificationXref10261
type: UnificationXref
id: 1524060
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524060

UnificationXref10264
type: UnificationXref
id: 6275181
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275181

UnificationXref10263
type: UnificationXref
id: Q9XFE5
db: UniProt

UnificationXref10260
type: UnificationXref
id: CHEBI:16436
db: ChEBI

hydrogencarbonate
type: SmallMolecule
entity reference: CHEBI_17544
data source: Provenance1
name: acid carbonate
name: bicarbonate
xref: UnificationXref3808
xref: UnificationXref3809
cellular location: GO_0005829
comment: Reactome DB_ID: 111627
display name: HCO3-

a xenobiotic
type: SmallMolecule
entity reference: CHEBI_35703
data source: Provenance1
xref: UnificationXref3709
xref: UnificationXref3708
cellular location: GO_0005576
comment: Reactome DB_ID: 1467459

UnificationXref10278
type: UnificationXref
id: 6275197
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275197

UnificationXref10279
type: UnificationXref
id: 6275198
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275198

UnificationXref10276
type: UnificationXref
id: 6275195
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275195

UnificationXref10277
type: UnificationXref
id: 6275196
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275196

Lithium ion
type: SmallMolecule
entity reference: CHEBI_49713
data source: Provenance1
xref: UnificationXref3896
xref: UnificationXref3897
cellular location: GO_0005829
comment: Reactome DB_ID: 425810
display name: Li+

Lithium ion
type: SmallMolecule
entity reference: CHEBI_49713
data source: Provenance1
xref: UnificationXref3894
xref: UnificationXref3895
cellular location: GO_0005576
comment: Reactome DB_ID: 425815
display name: Li+

Calcium
type: SmallMolecule
entity reference: CHEBI_29108
data source: Provenance1
xref: UnificationXref3872
xref: UnificationXref3873
cellular location: GO_0005576
comment: Reactome DB_ID: 74112
display name: Ca2+

Calcium
type: SmallMolecule
entity reference: CHEBI_29108
data source: Provenance1
xref: UnificationXref3870
xref: UnificationXref3871
cellular location: GO_0005829
comment: Reactome DB_ID: 74016
display name: Ca2+

H+
type: SmallMolecule
entity reference: CHEBI_15378
data source: Provenance1
xref: UnificationXref3853
xref: UnificationXref3852
cellular location: GO_0005576
comment: Reactome DB_ID: 351626

hydrogencarbonate
type: SmallMolecule
entity reference: CHEBI_17544
data source: Provenance1
name: acid carbonate
name: bicarbonate
xref: UnificationXref3815
xref: UnificationXref3816
cellular location: GO_0005576
comment: Reactome DB_ID: 425425
display name: HCO3-

Chloride
type: SmallMolecule
entity reference: CHEBI_17996
data source: Provenance1
xref: UnificationXref3814
xref: UnificationXref3813
cellular location: GO_0005829
comment: Reactome DB_ID: 352022
display name: Cl-

Chloride
type: SmallMolecule
entity reference: CHEBI_17996
data source: Provenance1
xref: UnificationXref3812
xref: UnificationXref3811
cellular location: GO_0005576
comment: Reactome DB_ID: 188972
display name: Cl-

UnificationXref10275
type: UnificationXref
id: 6275194
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275194

UnificationXref10274
type: UnificationXref
id: 6275193
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275193

UnificationXref10273
type: UnificationXref
id: 6275192
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275192

UnificationXref10272
type: UnificationXref
id: 6275191
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275191

UnificationXref10271
type: UnificationXref
id: B9FZ72
db: UniProt

UnificationXref10270
type: UnificationXref
id: 6275189
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275189

UnificationXref10672
type: UnificationXref
id: 6275925
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275925

UnificationXref10673
type: UnificationXref
id: Q10PS3
db: UniProt

Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence832
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.3.10
xref: UnificationXref9499
xref: UnificationXref9498
left: Water
left: SmallMolecule594
left: Acetyl coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: coenzyme A
right: SmallMolecule595

UnificationXref10674
type: UnificationXref
id: 6275926
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275926

UnificationXref10675
type: UnificationXref
id: 6275947
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275947

http://identifiers.org/pubmed/12807873
type: PublicationXref
id: 12807873
author: Kömüves, LG
author: Ng, CK
author: Topper, JN
author: Wasserman, SM
author: Yang, RB
author: Gerritsen, ME
db: Pubmed
title: A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling
source: J Biol Chem 278:33232-8
year: 2003

UnificationXref22046
type: UnificationXref
id: REACT_15653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15653.1

UnificationXref10676
type: UnificationXref
id: 6275949
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275949

UnificationXref22047
type: UnificationXref
id: 379709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379709

UnificationXref10677
type: UnificationXref
id: REACT_223641
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223641.2

UnificationXref22048
type: UnificationXref
id: 379759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379759

UnificationXref10678
type: UnificationXref
id: 6275981
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275981

UnificationXref22049
type: UnificationXref
id: REACT_15822
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15822.1

UnificationXref10679
type: UnificationXref
id: REACT_219647
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219647.2

UnificationXref22043
type: UnificationXref
id: 6267745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267745

Addition of isopentenyl pyrophosphate to DMAPP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence837
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.1
xref: UnificationXref9565
xref: UnificationXref9564
left: SmallMolecule600
left: SmallMolecule599
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule601

UnificationXref22042
type: UnificationXref
id: 6267743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267743

Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence838
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.10
xref: UnificationXref9569
xref: UnificationXref9570
left: SmallMolecule601
left: SmallMolecule599
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule602

UnificationXref22045
type: UnificationXref
id: 379774
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379774

Two FPP molecules dimerize to form presqualene diphosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence839
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.21
xref: UnificationXref9582
xref: UnificationXref9583
participant stoichiometry: Stoichiometry1116
left: SmallMolecule602
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule603

UnificationXref22044
type: UnificationXref
id: REACT_188083
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_188083.3

Reduction of presqualene diphosphate to form squalene
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence840
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.21
xref: UnificationXref9587
xref: UnificationXref9588
left: proton
left: NADPH
left: SmallMolecule603
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule340
right: SmallMolecule604

Reduction of HMG-CoA produces mevalonate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence833
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.34
xref: UnificationXref9505
xref: UnificationXref9504
participant stoichiometry: Stoichiometry1105
participant stoichiometry: Stoichiometry1106
participant stoichiometry: Stoichiometry1107
left: proton
left: NADPH
left: SmallMolecule595
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule596
right: coenzyme A

Ensembl:OS11T0658900-01
type: ProteinReference
xref: UnificationXref16944
organism: http://identifiers.org/taxonomy/4530

Mevalonate is phosphorylated to mevalonate-5-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence834
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.36
xref: UnificationXref9518
xref: UnificationXref9517
left: SmallMolecule5
left: SmallMolecule596
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule597

UnificationXref22041
type: UnificationXref
id: 6267742
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267742

Mevalonate-5-pyrophosphate is decarboxylated
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence835
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.33
xref: UnificationXref9532
xref: UnificationXref9531
left: SmallMolecule5
left: SmallMolecule598
display name: MVD decarboxylates MVA5PP to IPPP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule599

UnificationXref10671
type: UnificationXref
id: 6275924
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275924

UnificationXref22040
type: UnificationXref
id: 6267741
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267741

Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence836
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.3.2
xref: UnificationXref9543
xref: UnificationXref9542
left: SmallMolecule599
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule600

UnificationXref10670
type: UnificationXref
id: Q69YB0
db: UniProt

Squalene is oxidized to its epoxide
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence841
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.99.7
xref: UnificationXref9610
xref: UnificationXref9611
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule604
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule605

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

UnificationXref10669
type: UnificationXref
id: 6275923
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275923

lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence843
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.70
xref: UnificationXref9696
xref: UnificationXref9697
participant stoichiometry: Stoichiometry1124
participant stoichiometry: Stoichiometry1122
participant stoichiometry: Stoichiometry1123
participant stoichiometry: Stoichiometry1121
participant stoichiometry: Stoichiometry1125
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule606
display name: Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule460
right: Water
right: NADP+
right: SmallMolecule607

UnificationXref10663
type: UnificationXref
id: 6275920
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275920

Squalene 2,3-epoxide cyclizes, forming lanosterol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence842
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.99.7
xref: UnificationXref9658
xref: UnificationXref9659
left: SmallMolecule605
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule606

UnificationXref10664
type: UnificationXref
id: Q6ZC71
db: UniProt

UnificationXref10661
type: UnificationXref
id: 6275919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275919

UnificationXref10662
type: UnificationXref
id: Q10QV1
db: UniProt

UnificationXref22059
type: UnificationXref
id: 379710
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379710

UnificationXref10667
type: UnificationXref
id: 6275922
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275922

UnificationXref10668
type: UnificationXref
id: Q10QV0
db: UniProt

UnificationXref22057
type: UnificationXref
id: 379756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379756

UnificationXref10665
type: UnificationXref
id: 6275921
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275921

UnificationXref22058
type: UnificationXref
id: REACT_18191
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18191.1

UnificationXref10666
type: UnificationXref
id: Q6ZC72
db: UniProt

UnificationXref22056
type: UnificationXref
id: REACT_239143
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239143.1

Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence850
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.3.1
xref: UnificationXref9767
xref: UnificationXref9768
left: SmallMolecule619
display name: Zymosterol => cholesta-7,24-dien-3beta-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule620

UnificationXref22055
type: UnificationXref
id: 6267766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267766

cholesta-7,24-dien-3beta-ol + NADPH + H+ + O2 => cholesta-5,7,24-trien-3beta-ol + NADP+ + 2 H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence851
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9774
xref: UnificationXref9775
participant stoichiometry: Stoichiometry1136
left: proton
left: SmallMolecule620
left: SmallMolecule293
left: NADPH
display name: Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule621

UnificationXref22054
type: UnificationXref
id: 6267764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267764

4-methylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence848
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.72
xref: UnificationXref9753
xref: UnificationXref9752
participant stoichiometry: Stoichiometry1131
participant stoichiometry: Stoichiometry1132
participant stoichiometry: Stoichiometry1133
participant stoichiometry: Stoichiometry1135
participant stoichiometry: Stoichiometry1134
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule616
display name: 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule617

UnificationXref22053
type: UnificationXref
id: 6267763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267763

4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence849
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9758
xref: UnificationXref9757
left: DPN
left: SmallMolecule617
display name: 4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => cholesta-8(9),24-dien-3-one (zymosterone) + CO2 + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: NADH
right: proton
right: SmallMolecule618

UnificationXref22052
type: UnificationXref
id: Q5JKV1
db: UniProt

4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence846
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.72
xref: UnificationXref9733
xref: UnificationXref9732
participant stoichiometry: Stoichiometry1130
participant stoichiometry: Stoichiometry1128
participant stoichiometry: Stoichiometry1127
participant stoichiometry: Stoichiometry1129
participant stoichiometry: Stoichiometry1126
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule607
display name: 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule614

UnificationXref10660
type: UnificationXref
id: Q94HE9
db: UniProt

http://identifiers.org/pubmed/22090471
type: PublicationXref
id: 22090471
author: Jan, Lily Y
author: Huang, Fen
author: Wong, Xiuming
db: Pubmed
title: International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels
source: Pharmacol. Rev. 64:1-15
year: 2012

UnificationXref22051
type: UnificationXref
id: 6267761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267761

4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence847
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9745
xref: UnificationXref9744
left: SmallMolecule614
left: DPN
display name: 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => 4-methylcholesta-8(9),24-dien-3-one + CO2 + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: NADH
right: proton
right: SmallMolecule615

UnificationXref22050
type: UnificationXref
id: Q5JKV2
db: UniProt

4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [LBR]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence844
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.70
xref: UnificationXref9715
xref: UnificationXref9714
left: SmallMolecule610
left: SmallMolecule609
left: SmallMolecule608
display name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule611
right: SmallMolecule612

4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [TM7SF2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence845
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.70
xref: UnificationXref9721
xref: UnificationXref9720
left: proton
left: NADPH
left: SmallMolecule607
display name: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule613

UniProt:B7FAL5
type: ProteinReference
xref: UnificationXref21516
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/18481987
type: PublicationXref
id: 18481987
author: Sandler, H
author: Stoecklin, G
db: Pubmed
title: Control of mRNA decay by phosphorylation of tristetraprolin
source: Biochem Soc Trans 36:491-6
year: 2008

UniProt:B7FAL9
type: ProteinReference
xref: UnificationXref18677
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

UnificationXref22068
type: UnificationXref
id: 379735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379735

UnificationXref10698
type: UnificationXref
id: 6280038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280038

UnificationXref22069
type: UnificationXref
id: REACT_15875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15875.1

UnificationXref10699
type: UnificationXref
id: REACT_211107
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211107.2

cholesta-5,7,24-trien-3beta-ol + NADPH + H+ => desmosterol + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence852
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.21
xref: UnificationXref9785
xref: UnificationXref9784
left: proton
left: SmallMolecule621
left: NADPH
display name: Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule622

UnificationXref10694
type: UnificationXref
id: 6275822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275822

http://identifiers.org/pubmed/12807890
type: PublicationXref
id: 12807890
author: Walker, JE
author: Dionisi-Vici, C
author: Dolce, V
author: Palmieri, F
author: Fiermonte, G
author: David, L
author: Santorelli, FM
db: Pubmed
title: The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
source: J Biol Chem 278:32778-83
year: 2003

UnificationXref10695
type: UnificationXref
id: 6275823
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275823

Expression of Farnesyl Diphosphate Synthase (FDPS)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence855
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9798
xref: UnificationXref9797
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein3931

UnificationXref10696
type: UnificationXref
id: 6275825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275825

desmosterol + NADPH + H+ => cholesterol + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence853
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.1.72
xref: UnificationXref9794
xref: UnificationXref9793
left: proton
left: NADPH
left: SmallMolecule622
display name: Reduction of desmosterol to cholesterol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule623

UnificationXref10697
type: UnificationXref
id: REACT_224825
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224825.2

UnificationXref22061
type: UnificationXref
id: 379755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379755

Expression of Lathosterol Oxidase (SC5D, SC5DL)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence856
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9801
xref: UnificationXref9800
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein4004

UnificationXref10691
type: UnificationXref
id: 6275819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275819

UnificationXref22060
type: UnificationXref
id: REACT_15744
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15744.2

Expression of Squalene Monooxygenase (SQLE)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence857
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9803
xref: UnificationXref9804
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein3943

UnificationXref10690
type: UnificationXref
id: Q5KQN2
db: UniProt

UnificationXref22063
type: UnificationXref
id: Q943W5
db: UniProt

Expression of TM7SF2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence858
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9806
xref: UnificationXref9807
left: Complex459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein3994

UnificationXref10693
type: UnificationXref
id: 6275821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275821

UnificationXref22062
type: UnificationXref
id: REACT_15651
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15651.1

7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence861
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.145
xref: UnificationXref9821
xref: UnificationXref9822
left: SmallMolecule624
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule625

UnificationXref10692
type: UnificationXref
id: Q75LV1
db: UniProt

UnificationXref22065
type: UnificationXref
id: 6267705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267705

25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence862
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.6
xref: UnificationXref9830
xref: UnificationXref9829
left: SmallMolecule566
left: SmallMolecule626
display name: 25(S) THCA-CoA + O2 => THCA-CoA + H2O2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule568
right: SmallMolecule627

UnificationXref22064
type: UnificationXref
id: 6267704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267704

25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence863
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.6
xref: UnificationXref9837
xref: UnificationXref9838
left: SmallMolecule566
left: SmallMolecule628
display name: 25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule568
right: SmallMolecule629

UnificationXref22067
type: UnificationXref
id: REACT_259183
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259183.1

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence864
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.107
xref: UnificationXref9842
xref: UnificationXref9843
left: SmallMolecule570
left: SmallMolecule627
display name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule630

UnificationXref22066
type: UnificationXref
id: 6267707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267707

UniProt:Q94JJ0
type: ProteinReference
xref: UnificationXref6855
organism: http://identifiers.org/taxonomy/4530

Folding of actin by CCT/TriC
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1146
evidence: Evidence1763
xref: UnificationXref19038
xref: UnificationXref19037
xref: RelationshipXref1495
pathway order: PathwayStep1741
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref10689
type: UnificationXref
id: REACT_123549
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123549.1

UnificationXref22079
type: UnificationXref
id: 6279847
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279847

UnificationXref10687
type: UnificationXref
id: REACT_252743
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252743.1

UnificationXref10688
type: UnificationXref
id: 1806165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806165

Hydrolysis of choloyl-CoA to cholate and CoASH
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence868
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9866
xref: UnificationXref9865
left: SmallMolecule634
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule578
right: SmallMolecule635

UnificationXref10685
type: UnificationXref
id: 6276071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276071

(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence867
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref9857
xref: UnificationXref9858
left: SmallMolecule572
left: SmallMolecule631
display name: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule575
right: SmallMolecule574
right: SmallMolecule633

UnificationXref10686
type: UnificationXref
id: 6276073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276073

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence866
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref9852
xref: UnificationXref9853
left: SmallMolecule572
left: SmallMolecule630
display name: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule575
right: SmallMolecule574
right: SmallMolecule632

UnificationXref10683
type: UnificationXref
id: Q2QT46
db: UniProt

25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence865
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.107
xref: UnificationXref9848
xref: UnificationXref9847
left: SmallMolecule570
left: SmallMolecule629
display name: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule631

UnificationXref10684
type: UnificationXref
id: 6276070
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276070

UnificationXref22074
type: UnificationXref
id: Q7G2B1
db: UniProt

Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence872
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.145
xref: UnificationXref9941
xref: UnificationXref9942
left: SmallMolecule647
left: DPN
display name: Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule648

UnificationXref10682
type: UnificationXref
id: REACT_124713
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124713.1

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

UnificationXref22073
type: UnificationXref
id: 6267722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267722

Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence874
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.145
xref: UnificationXref9952
xref: UnificationXref9951
left: SmallMolecule649
left: DPN
display name: Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule650

UnificationXref10681
type: UnificationXref
id: 1806230
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806230

UnificationXref22072
type: UnificationXref
id: B9G6I9
db: UniProt

Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence869
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9922
xref: UnificationXref9921
left: Water
left: SmallMolecule636
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule6
right: SmallMolecule641

UnificationXref10680
type: UnificationXref
id: CHEBI:16152
db: ChEBI

UnificationXref22071
type: UnificationXref
id: REACT_15572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15572.1

cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence871
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.98
xref: UnificationXref9933
xref: UnificationXref9934
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule623
display name: Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule646
right: Water
right: NADP+

UnificationXref22078
type: UnificationXref
id: REACT_188117
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_188117.3

UnificationXref22077
type: UnificationXref
id: 6267727
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267727

UnificationXref22076
type: UnificationXref
id: 6267725
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267725

Cholesterol is hydroxylated to 25-hydroxycholesterol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence876
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref9969
xref: UnificationXref9970
left: cholesterol
left: proton
left: SmallMolecule293
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule651

UnificationXref22075
type: UnificationXref
id: 6267724
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267724

PC is hydrolyzed to PA and choline by PLD1/2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence881
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.4
xref: UnificationXref10031
xref: UnificationXref10032
left: Water
left: SmallMolecule652
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule530
right: SmallMolecule229

UnificationXref22070
type: UnificationXref
id: 379782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379782

UnificationXref10631
type: UnificationXref
id: A3BTC2
db: UniProt

UnificationXref10630
type: UnificationXref
id: 6275934
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275934

UnificationXref10633
type: UnificationXref
id: Q84MW6
db: UniProt

UnificationXref10632
type: UnificationXref
id: 6275935
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275935

UnificationXref10635
type: UnificationXref
id: Q0J5A9
db: UniProt

UnificationXref10634
type: UnificationXref
id: 6275936
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275936

UnificationXref14793
type: UnificationXref
id: 6266597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266597

UnificationXref10637
type: UnificationXref
id: Q8H3L8
db: UniProt

UnificationXref14794
type: UnificationXref
id: OS09T0380300-01
db: Ensembl

UnificationXref10636
type: UnificationXref
id: 6275937
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275937

UnificationXref14795
type: UnificationXref
id: 6266598
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266598

UnificationXref10639
type: UnificationXref
id: Q6ZJN4
db: UniProt

UnificationXref14796
type: UnificationXref
id: B9FR53
db: UniProt

UnificationXref10638
type: UnificationXref
id: 6275938
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275938

UnificationXref14790
type: UnificationXref
id: B9FXJ4
db: UniProt

UnificationXref14791
type: UnificationXref
id: 6266596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266596

UnificationXref14792
type: UnificationXref
id: B7EZM0
db: UniProt

UnificationXref22080
type: UnificationXref
id: REACT_227647
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227647.2

UnificationXref22081
type: UnificationXref
id: 6279409
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279409

UnificationXref14798
type: UnificationXref
id: Q8H848
db: UniProt

UnificationXref14797
type: UnificationXref
id: 6266599
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266599

UnificationXref14799
type: UnificationXref
id: 6266600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266600

UnificationXref22086
type: UnificationXref
id: REACT_20913
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20913.1

UnificationXref22087
type: UnificationXref
id: Q5JLX2
db: UniProt

http://identifiers.org/pubmed/9799232
type: PublicationXref
id: 9799232
author: Wagner, H
author: Mischak, H
author: Sparwasser, T
author: Lipford, GB
author: Schmid, R
author: Heeg, K
author: Miethke, T
author: Hacker, H
author: Liptay, S
db: Pubmed
title: CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
source: EMBO J 17:6230-40
year: 1998

UnificationXref22088
type: UnificationXref
id: 6269690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269690

UnificationXref22089
type: UnificationXref
id: Q0JKN6
db: UniProt

UnificationXref22082
type: UnificationXref
id: REACT_201930
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201930.2

http://identifiers.org/pubmed/9799231
type: PublicationXref
id: 9799231
author: Guillemot, JC
author: Chavrier, P
author: Montcourrier, P
author: Massol, P
db: Pubmed
title: Fc receptor-mediated phagocytosis requires CDC42 and Rac1
source: EMBO J 17:6219-29
year: 1998

UnificationXref22083
type: UnificationXref
id: 429974
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429974

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

UnificationXref22084
type: UnificationXref
id: REACT_20743
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20743.1

UnificationXref22085
type: UnificationXref
id: 429926
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429926

UnificationXref10620
type: UnificationXref
id: 6275929
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275929

UnificationXref10624
type: UnificationXref
id: 6275931
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275931

UnificationXref10623
type: UnificationXref
id: A3BTP9
db: UniProt

UnificationXref10622
type: UnificationXref
id: 6275930
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275930

UnificationXref10621
type: UnificationXref
id: Q2QVA9
db: UniProt

UnificationXref14784
type: UnificationXref
id: A3AWB6
db: UniProt

UnificationXref10628
type: UnificationXref
id: 6275933
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275933

UnificationXref14785
type: UnificationXref
id: 6266593
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266593

UnificationXref10627
type: UnificationXref
id: B9FSL8
db: UniProt

UnificationXref14782
type: UnificationXref
id: Q2RAP4
db: UniProt

UnificationXref10626
type: UnificationXref
id: 6275932
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275932

UnificationXref14783
type: UnificationXref
id: 6266592
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266592

UnificationXref10625
type: UnificationXref
id: B9F8W5
db: UniProt

UnificationXref14780
type: UnificationXref
id: Q7XNH3
db: UniProt

UnificationXref14781
type: UnificationXref
id: 6266591
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266591

UnificationXref10629
type: UnificationXref
id: Q6ZLF2
db: UniProt

UnificationXref22091
type: UnificationXref
id: 6269694
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269694

UnificationXref22092
type: UnificationXref
id: Q0DWG8
db: UniProt

UnificationXref22090
type: UnificationXref
id: 6269693
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269693

UnificationXref14789
type: UnificationXref
id: 6266595
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266595

UnificationXref14788
type: UnificationXref
id: A3C477
db: UniProt

UnificationXref14787
type: UnificationXref
id: 6266594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266594

UnificationXref14786
type: UnificationXref
id: Q8RU58
db: UniProt

UnificationXref22099
type: UnificationXref
id: Q7XUA1
db: UniProt

UnificationXref22097
type: UnificationXref
id: B9ET84
db: UniProt

UnificationXref22098
type: UnificationXref
id: 6269697
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269697

UnificationXref22095
type: UnificationXref
id: 6269705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269705

UnificationXref22096
type: UnificationXref
id: 6269706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269706

UnificationXref22093
type: UnificationXref
id: 6269703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269703

UnificationXref22094
type: UnificationXref
id: Q6K6B9
db: UniProt

Ensembl:OS01T0540300-00
type: ProteinReference
xref: UnificationXref16719
organism: http://identifiers.org/taxonomy/4530

UnificationXref10655
type: UnificationXref
id: 6275916
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275916

UnificationXref10654
type: UnificationXref
id: B9FYP8
db: UniProt

UnificationXref10657
type: UnificationXref
id: 6275917
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275917

UnificationXref10656
type: UnificationXref
id: A3AET8
db: UniProt

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

UnificationXref10651
type: UnificationXref
id: OS09T0278300-00
db: Ensembl

UnificationXref10650
type: UnificationXref
id: 6275944
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275944

UnificationXref10653
type: UnificationXref
id: 6275946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275946

UnificationXref10652
type: UnificationXref
id: 6275945
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275945

UnificationXref10659
type: UnificationXref
id: 6275918
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275918

UnificationXref10658
type: UnificationXref
id: OS06T0355150-00
db: Ensembl

http://identifiers.org/pubmed/12032886
type: PublicationXref
id: 12032886
author: Zhou, B
author: Wang, K
author: Gitschier, J
author: Zemansky, J
author: Kuo, YM
db: Pubmed
title: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
source: Am J Hum Genet 71:66-73
year: 2002

Ensembl:OS03T0341200-00
type: ProteinReference
xref: UnificationXref16391
organism: http://identifiers.org/taxonomy/4530

UnificationXref10646
type: UnificationXref
id: 6275942
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275942

UnificationXref10645
type: UnificationXref
id: Q652R9
db: UniProt

UnificationXref10644
type: UnificationXref
id: 6275941
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275941

UnificationXref10643
type: UnificationXref
id: Q69MW6
db: UniProt

UnificationXref10642
type: UnificationXref
id: 6275940
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275940

UnificationXref10641
type: UnificationXref
id: Q94LF4
db: UniProt

UnificationXref10640
type: UnificationXref
id: 6275939
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275939

UnificationXref10649
type: UnificationXref
id: Q0J8R0
db: UniProt

UnificationXref10648
type: UnificationXref
id: 6275943
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275943

UnificationXref10647
type: UnificationXref
id: B9G3H3
db: UniProt

malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence830
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.9
xref: RelationshipXref660
xref: UnificationXref9491
xref: UnificationXref9490
left: SmallMolecule593
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule576
right: SmallMolecule591

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence828
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.42
xref: UnificationXref9480
xref: UnificationXref9479
left: NADP+
left: SmallMolecule592
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: proton
right: SmallMolecule235
right: NADPH

trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence820
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.74
xref: UnificationXref9391
xref: UnificationXref9390
left: SmallMolecule581
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule582

hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence819
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.6
xref: UnificationXref9386
xref: UnificationXref9385
left: SmallMolecule566
left: SmallMolecule580
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule568
right: SmallMolecule581

Peroxisomal uptake of very long-chain fatty acyl CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence818
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.3.47
xref: UnificationXref9378
xref: UnificationXref9379
left: SmallMolecule579
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule580

acetyl-CoA + H2O => acetate + CoASH
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence816
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.2.1
xref: UnificationXref9369
xref: UnificationXref9370
left: SmallMolecule576
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule577
right: SmallMolecule578

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence827
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.42
xref: UnificationXref9467
xref: UnificationXref9468
left: SmallMolecule589
left: SmallMolecule587
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule575
right: SmallMolecule586
right: SmallMolecule591
right: SmallMolecule590

palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence824
evidence: Evidence825
conversion direction: LEFT_TO_RIGHT
EC number: 1
xref: UnificationXref9449
xref: UnificationXref9448
participant stoichiometry: Stoichiometry1101
participant stoichiometry: Stoichiometry1102
participant stoichiometry: Stoichiometry1100
left: SmallMolecule575
left: SmallMolecule586
left: SmallMolecule585
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule588
right: SmallMolecule578
right: SmallMolecule587

Ensembl:OS11T0109933-01
type: ProteinReference
xref: UnificationXref16499
organism: http://identifiers.org/taxonomy/4530

3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence822
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.16
xref: UnificationXref9405
xref: UnificationXref9404
left: SmallMolecule578
left: SmallMolecule583
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule576
right: SmallMolecule584

3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence821
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.35
xref: UnificationXref9396
xref: UnificationXref9395
left: SmallMolecule572
left: SmallMolecule582
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule575
right: SmallMolecule583
right: SmallMolecule574

UniProt:B7FAE9
type: ProteinReference
xref: UnificationXref11459
organism: http://identifiers.org/taxonomy/4530

CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence947
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10519
xref: UnificationXref10520
left: SmallMolecule702
left: SmallMolecule707
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule667
right: SmallMolecule703

UnificationXref14759
type: UnificationXref
id: 6266580
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266580

UnificationXref14757
type: UnificationXref
id: 6266579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266579

UnificationXref14758
type: UnificationXref
id: Q7EZ52
db: UniProt

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

UnificationXref14755
type: UnificationXref
id: 6266578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266578

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

UnificationXref14756
type: UnificationXref
id: B7EAV7
db: UniProt

UnificationXref14753
type: UnificationXref
id: 6266577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266577

UnificationXref14754
type: UnificationXref
id: Q5VRM7
db: UniProt

UnificationXref14752
type: UnificationXref
id: A3BKD8
db: UniProt

1-acyl LPG is acylated to PG by LPGAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence936
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10461
xref: UnificationXref10462
left: SmallMolecule696
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule689
right: coenzyme A

UnificationXref14751
type: UnificationXref
id: 6266576
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266576

UnificationXref14750
type: UnificationXref
id: Q5CCK2
db: UniProt

MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence946
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10518
xref: UnificationXref10517
left: SmallMolecule667
left: SmallMolecule703
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule702
right: SmallMolecule707

CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence945
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.23
xref: UnificationXref10514
xref: UnificationXref10513
left: SmallMolecule702
left: SmallMolecule706
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule703
right: SmallMolecule705

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence944
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10512
xref: UnificationXref10511
left: SmallMolecule703
left: SmallMolecule705
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule702
right: SmallMolecule706

CL is hydrolyzed to MLCL by PLA2G6 (IM)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence943
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.4
xref: UnificationXref10501
xref: UnificationXref10500
left: SmallMolecule702
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule703
right: SmallMolecule704

PG and CDP-DAG are converted to CL by CRLS1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence941
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10490
xref: UnificationXref10491
left: SmallMolecule692
left: SmallMolecule695
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule702
right: SmallMolecule701

2-acyl LPG is acylated to PG by CRLS1 (IM)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence939
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10481
xref: UnificationXref10482
left: SmallMolecule698
left: SmallMolecule700
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule433
right: SmallMolecule695

http://identifiers.org/pubmed/16682955
type: PublicationXref
id: 16682955
author: Hays, S
author: Westbrook, L
author: Qu, Z
author: Kern, FG
author: Thottassery, JV
author: Rentz, SS
author: Manuvakhova, M
db: Pubmed
title: Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
source: Oncogene 25:6003-14
year: 2006

1-acyl LPG is acylated to PG by CRLS1 (IM)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence938
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10478
xref: UnificationXref10477
left: SmallMolecule698
left: SmallMolecule699
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule433
right: SmallMolecule695

2-acyl LPG is acylated to PG by LPGAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence937
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10467
xref: UnificationXref10466
left: SmallMolecule528
left: SmallMolecule697
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule689
right: coenzyme A

UnificationXref14746
type: UnificationXref
id: Q0IY22
db: UniProt

UnificationXref14747
type: UnificationXref
id: 6266574
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266574

UnificationXref14748
type: UnificationXref
id: Q5CCK3
db: UniProt

UnificationXref14749
type: UnificationXref
id: 6266575
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266575

UnificationXref14742
type: UnificationXref
id: Q7XIL3
db: UniProt

UnificationXref14743
type: UnificationXref
id: 6266572
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266572

UnificationXref14744
type: UnificationXref
id: Q0JAX2
db: UniProt

UnificationXref14745
type: UnificationXref
id: 6266573
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266573

UnificationXref14741
type: UnificationXref
id: 6266571
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266571

UniProt:P49216
type: ProteinReference
xref: UnificationXref17939
organism: http://identifiers.org/taxonomy/4530

UnificationXref14740
type: UnificationXref
id: Q338Z0
db: UniProt

UniProt:P49210
type: ProteinReference
xref: UnificationXref18130
organism: http://identifiers.org/taxonomy/4530

UnificationXref14777
type: UnificationXref
id: 6266589
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266589

UnificationXref14778
type: UnificationXref
id: C7J4Y5
db: UniProt

UniProt:B7FAC2
type: ProteinReference
xref: UnificationXref21525
organism: http://identifiers.org/taxonomy/4530

UnificationXref14775
type: UnificationXref
id: 6266588
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266588

UnificationXref14776
type: UnificationXref
id: Q0JAX3
db: UniProt

UnificationXref14779
type: UnificationXref
id: 6266590
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266590

UnificationXref14770
type: UnificationXref
id: Q7XU38
db: UniProt

UnificationXref10618
type: UnificationXref
id: 6275928
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275928

UnificationXref10619
type: UnificationXref
id: Q7XKA1
db: UniProt

UnificationXref14774
type: UnificationXref
id: B9FK04
db: UniProt

UnificationXref10616
type: UnificationXref
id: 6275927
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275927

UnificationXref14773
type: UnificationXref
id: 6266587
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266587

UnificationXref10617
type: UnificationXref
id: Q0J5A8
db: UniProt

UnificationXref14772
type: UnificationXref
id: C7J7B8
db: UniProt

UnificationXref10614
type: UnificationXref
id: REACT_125341
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125341.1

UnificationXref14771
type: UnificationXref
id: 6266586
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266586

UnificationXref10615
type: UnificationXref
id: Q0J1X6
db: UniProt

UnificationXref10612
type: UnificationXref
id: CHEBI:16851
db: ChEBI

UnificationXref10613
type: UnificationXref
id: 1806290
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806290

UnificationXref10610
type: UnificationXref
id: 6276005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276005

UnificationXref10611
type: UnificationXref
id: REACT_202594
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202594.2

http://identifiers.org/pubmed/11427893
type: PublicationXref
id: 11427893
author: Ramaswamy, S
author: Eklund, H
author: Eriksson, S
author: Piskur, J
author: Munch-Petersen, B
author: Johansson, K
author: Knecht, W
author: Ljungcrantz, C
db: Pubmed
title: Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
source: Nat Struct Biol 8:616-620
year: 2001

UnificationXref14764
type: UnificationXref
id: Q7XU41
db: UniProt

UnificationXref14765
type: UnificationXref
id: 6266583
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266583

UnificationXref14766
type: UnificationXref
id: B9G4T8
db: UniProt

UnificationXref14767
type: UnificationXref
id: 6266584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266584

UnificationXref14768
type: UnificationXref
id: Q109R7
db: UniProt

UnificationXref14769
type: UnificationXref
id: 6266585
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266585

UnificationXref10607
type: UnificationXref
id: 6275952
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275952

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

UnificationXref10608
type: UnificationXref
id: 6275967
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275967

UnificationXref10609
type: UnificationXref
id: REACT_220858
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220858.2

ubiquitinylated lysine
type: SequenceModificationVocabulary
xref: UnificationXref22488

UnificationXref14761
type: UnificationXref
id: 6266581
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266581

UnificationXref10603
type: UnificationXref
id: B9F414
db: UniProt

UnificationXref14760
type: UnificationXref
id: Q84LG7
db: UniProt

UnificationXref10604
type: UnificationXref
id: 6263213
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263213

UnificationXref14763
type: UnificationXref
id: 6266582
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266582

UnificationXref10605
type: UnificationXref
id: 6263214
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263214

UnificationXref14762
type: UnificationXref
id: Q05JG2
db: UniProt

UnificationXref10606
type: UnificationXref
id: 6275951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275951

UnificationXref10600
type: UnificationXref
id: 6263209
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263209

UnificationXref10601
type: UnificationXref
id: Q6KAK1
db: UniProt

http://identifiers.org/pubmed/15591024
type: PublicationXref
id: 15591024
author: Takano, K
author: Yoshida, M
author: Asai, M
author: Oiso, Y
author: Itoi, K
author: Yamamori, E
author: Iwasaki, Y
db: Pubmed
title: Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
source: J Mol Endocrinol 33:639-49
year: 2004

UnificationXref10602
type: UnificationXref
id: 6263211
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263211

http://identifiers.org/pubmed/8163536
type: PublicationXref
id: 8163536
author: Sidorenko, SP
author: Chandran, KA
author: Clark, EA
author: Disteche, CM
author: Edelhoff, S
author: Law, CL
author: Weiss, A
author: Chan, AC
author: Draves, KE
db: Pubmed
title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex
source: J Biol Chem 269:12310-9
year: 1994

Stoichiometry1809
type: Stoichiometry
physical entity: PhysicalEntity199
stoichiometric coefficient: 1.0

UnificationXref14716
type: UnificationXref
id: 352318
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352318

Stoichiometry1808
type: Stoichiometry
physical entity: Complex799
stoichiometric coefficient: 1.0

UnificationXref14715
type: UnificationXref
id: CHEBI:63590
db: ChEBI

Stoichiometry1807
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

UnificationXref14714
type: UnificationXref
id: REACT_249131
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249131.1

Stoichiometry1806
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref14713
type: UnificationXref
id: 6266559
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266559

Stoichiometry1805
type: Stoichiometry
physical entity: PhysicalEntity198
stoichiometric coefficient: 1.0

UnificationXref14712
type: UnificationXref
id: 6266557
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266557

Stoichiometry1804
type: Stoichiometry
physical entity: Protein6029
stoichiometric coefficient: 1.0

UnificationXref14711
type: UnificationXref
id: 6266556
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266556

Stoichiometry1803
type: Stoichiometry
physical entity: Protein6028
stoichiometric coefficient: 1.0

UnificationXref14710
type: UnificationXref
id: 6266555
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266555

Stoichiometry1802
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 2.0

Cellular responses to stress
type: Pathway
data source: Provenance1
pathway component: REACT 175687.3
pathway component: REACT 223094.2
pathway component: REACT 227997.2
evidence: Evidence1710
xref: UnificationXref17708
xref: UnificationXref17707
xref: RelationshipXref1468
pathway order: PathwayStep1689
pathway order: PathwayStep1662
pathway order: PathwayStep1680
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref22000
type: UnificationXref
id: 6267687
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267687

Stoichiometry1801
type: Stoichiometry
physical entity: Complex799
stoichiometric coefficient: 1.0

UnificationXref22001
type: UnificationXref
id: Q10Q53
db: UniProt

Stoichiometry1800
type: Stoichiometry
physical entity: Protein6027
stoichiometric coefficient: 1.0

PA is dephosphorylated to DAG by LPIN
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence893
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.4
xref: UnificationXref10178
xref: UnificationXref10177
left: SmallMolecule530
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule474
right: SmallMolecule3

PETA and CTP are condensed to CDP-ETA by PCY2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence892
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.14
xref: UnificationXref10167
xref: UnificationXref10166
left: SmallMolecule659
left: SmallMolecule658
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule660

UnificationXref14719
type: UnificationXref
id: 6266402
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266402

PETA is dephosphorylated to ETA by PHOSPHO1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence891
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10147
xref: UnificationXref10148
left: SmallMolecule658
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule657
right: SmallMolecule3

UnificationXref14718
type: UnificationXref
id: 6266401
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266401

ETA is phosphorylated to PETA by CHK/ETNK
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence890
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.82
xref: UnificationXref10133
xref: UnificationXref10134
left: SmallMolecule657
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule658
right: SmallMolecule6

UnificationXref14717
type: UnificationXref
id: REACT_14303
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14303.1

2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence888
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.23
xref: UnificationXref10094
xref: UnificationXref10093
left: Water
left: SmallMolecule655
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule511
right: SmallMolecule656

UnificationXref22009
type: UnificationXref
id: 379789
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379789

2-MAG is transacylated to DAG by PNPLA2/3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence886
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10062
xref: UnificationXref10061
participant stoichiometry: Stoichiometry1139
left: SmallMolecule655
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule511
right: SmallMolecule474

http://identifiers.org/pubmed/15270074
type: PublicationXref
id: 15270074
author: Kingston, Robert E
author: Chen, Will C
author: Trinklein, Nathan D
author: Myers, Richard M
db: Pubmed
title: Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
source: Cell Stress Chaperones 9:21-8
year: 2004

UnificationXref22008
type: UnificationXref
id: REACT_17466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17466.1

2-MAG and DAG are transacylated to TAG by PNPLA2/3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence887
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10064
xref: UnificationXref10063
left: SmallMolecule474
left: SmallMolecule655
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule511
right: SmallMolecule653

http://identifiers.org/pubmed/11735028
type: PublicationXref
id: 11735028
author: Minoshima, S
author: Hiratsuka, M
author: Inui, K
author: Kure, S
author: Narisawa, K
author: Yang, X
author: Aoki, Y
author: Ohki, M
author: Kudoh, J
author: Shintani, A
author: Christensen, E
author: Kubota, M
author: Li, X
author: Taheri, S
author: Suzuki, Y
author: Kawasaki, K
author: Sakamoto, O
author: Shimizu, N
author: Asakawa, S
author: Shibuya, K
author: Ohira, M
author: Matsubara, Y
db: Pubmed
title: Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiency
source: Hum. Genet. 109:526-34
year: 2001

UnificationXref22007
type: UnificationXref
id: 379760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379760

DAG is acylated to TAG by DGAT1/2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence884
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.20
xref: UnificationXref10056
xref: UnificationXref10055
left: SmallMolecule474
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: coenzyme A
right: SmallMolecule653

UnificationXref22006
type: UnificationXref
id: 379701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379701

DAG is hydrolyzed to 2-MAG by PNPLA2/3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence885
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.34
xref: UnificationXref10060
xref: UnificationXref10059
left: SmallMolecule474
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule655
right: SmallMolecule654

UnificationXref22005
type: UnificationXref
id: REACT_188045
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_188045.3

UnificationXref22004
type: UnificationXref
id: 6267692
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267692

TAG is hydrolyzed to DAG by PNPLA2/3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence883
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.3
xref: UnificationXref10052
xref: UnificationXref10053
left: Water
left: SmallMolecule653
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule474
right: SmallMolecule654

UnificationXref22003
type: UnificationXref
id: 6267690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267690

UnificationXref22002
type: UnificationXref
id: 6267689
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267689

Stoichiometry1818
type: Stoichiometry
physical entity: Protein6031
stoichiometric coefficient: 1.0

UnificationXref14703
type: UnificationXref
id: A3A3M4
db: UniProt

Stoichiometry1817
type: Stoichiometry
physical entity: Complex799
stoichiometric coefficient: 1.0

UnificationXref14702
type: UnificationXref
id: REACT_14354
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14354.2

UnificationXref14705
type: UnificationXref
id: Q6H516
db: UniProt

Stoichiometry1819
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 2.0

UnificationXref14704
type: UnificationXref
id: 6266549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266549

Stoichiometry1814
type: Stoichiometry
physical entity: Protein6030
stoichiometric coefficient: 1.0

Stoichiometry1813
type: Stoichiometry
physical entity: PhysicalEntity199
stoichiometric coefficient: 1.0

Stoichiometry1816
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

UnificationXref14701
type: UnificationXref
id: 215075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=215075

Stoichiometry1815
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref14700
type: UnificationXref
id: CHEBI:19138
db: ChEBI

Stoichiometry1810
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref22010
type: UnificationXref
id: REACT_16119
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16119.1

UnificationXref22011
type: UnificationXref
id: Q0IMX0
db: UniProt

Stoichiometry1812
type: Stoichiometry
physical entity: Complex799
stoichiometric coefficient: 1.0

UnificationXref22012
type: UnificationXref
id: 6267748
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267748

Stoichiometry1811
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

Vitamins B6 activation to pyridoxal phosphate
type: Pathway
data source: Provenance1
pathway component: 2xPDXK:2xZn2+ phosphorylates PXA
pathway component: 2xPDKX:2xZn2+ phosphorylates PDX
pathway component: PLP results from phosphorylation of pyridoxal
pathway component: AOX1 oxidises PXL to PDXate
evidence: Evidence639
xref: RelationshipXref467
xref: UnificationXref7730
xref: UnificationXref7729
pathway order: PathwayStep624
pathway order: PathwayStep625
pathway order: PathwayStep626
pathway order: PathwayStep627
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref14707
type: UnificationXref
id: Q0E3I8
db: UniProt

PCho is dephosphorylated to Cho by PHOSPHO1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence904
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10259
xref: UnificationXref10258
left: Water
left: SmallMolecule672
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule229

UnificationXref14706
type: UnificationXref
id: 6266551
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266551

Cho is phosphorylated to PCho by CHK dimer
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence903
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.32
xref: UnificationXref10257
xref: UnificationXref10256
left: SmallMolecule229
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule672

UnificationXref14709
type: UnificationXref
id: B7ECI4
db: UniProt

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence906
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.8.2
xref: UnificationXref10286
xref: UnificationXref10285
left: SmallMolecule474
left: SmallMolecule673
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule253
right: SmallMolecule652

UnificationXref14708
type: UnificationXref
id: 6266553
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266553

PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence905
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.15
xref: UnificationXref10284
xref: UnificationXref10283
left: SmallMolecule659
left: SmallMolecule672
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule673

UnificationXref22018
type: UnificationXref
id: 379732
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379732

PE is hydrolyzed to 1-acyl LPE by PLA2[2]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence897
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.4
xref: UnificationXref10219
xref: UnificationXref10218
left: Water
left: SmallMolecule662
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule669
right: SmallMolecule654

UnificationXref22017
type: UnificationXref
id: REACT_188093
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_188093.3

1-acyl LPE is acylated to PE by LPEAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence898
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10226
xref: UnificationXref10225
left: SmallMolecule669
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule662
right: coenzyme A

2-acyl LPE is acylated to PE by LPEAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence899
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10230
xref: UnificationXref10231
left: SmallMolecule670
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule662
right: coenzyme A

UnificationXref22019
type: UnificationXref
id: REACT_15595
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15595.2

GPETA is hydrolyzed to ETA and G3P by GPCPD1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence901
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.46
xref: UnificationXref10248
xref: UnificationXref10249
left: Water
left: SmallMolecule671
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule657
right: SmallMolecule527

UnificationXref22014
type: UnificationXref
id: 6267750
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267750

UnificationXref22013
type: UnificationXref
id: Q2QPD4
db: UniProt

UnificationXref22016
type: UnificationXref
id: 6267753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267753

CDP-ETA and DAG are converted to PE by CEPT1/EPT1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence894
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.8.1
xref: UnificationXref10194
xref: UnificationXref10195
left: SmallMolecule474
left: SmallMolecule660
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule253
right: SmallMolecule662

UnificationXref22015
type: UnificationXref
id: 6267751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267751

PS is decarboxylated to PE by PISD
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence895
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.1.65
xref: UnificationXref10209
xref: UnificationXref10210
left: SmallMolecule665
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule667
right: SmallMolecule666

Stoichiometry1827
type: Stoichiometry
physical entity: Protein6031
stoichiometric coefficient: 1.0

UnificationXref14734
type: UnificationXref
id: B9GBT8
db: UniProt

Stoichiometry1826
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 2.0

UnificationXref14733
type: UnificationXref
id: REACT_14163
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14163.2

Stoichiometry1825
type: Stoichiometry
physical entity: PhysicalEntity201
stoichiometric coefficient: 1.0

UnificationXref14732
type: UnificationXref
id: 215584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=215584

Stoichiometry1824
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 2.0

UnificationXref14731
type: UnificationXref
id: CHEBI:63795
db: ChEBI

UnificationXref14738
type: UnificationXref
id: Q8H519
db: UniProt

UnificationXref14737
type: UnificationXref
id: 6266569
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266569

Stoichiometry1829
type: Stoichiometry
physical entity: Complex807
stoichiometric coefficient: 1.0

UnificationXref14736
type: UnificationXref
id: Q8H515
db: UniProt

Stoichiometry1828
type: Stoichiometry
physical entity: Protein6027
stoichiometric coefficient: 1.0

UnificationXref14735
type: UnificationXref
id: 6266568
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266568

PC is converted to PS by PTDSS1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence920
conversion direction: LEFT_TO_RIGHT
EC number: 2
xref: UnificationXref10357
xref: UnificationXref10356
left: SmallMolecule116
left: SmallMolecule652
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule229
right: SmallMolecule683

GPCho is hydrolyzed to Cho and G3P by GPCPD1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence918
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.46
xref: UnificationXref10346
xref: UnificationXref10345
left: Water
left: SmallMolecule682
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule229
right: SmallMolecule527

UnificationXref14739
type: UnificationXref
id: 6266570
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266570

2-acyl LPC is acylated to PC by LPCAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence916
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10338
xref: UnificationXref10339
left: SmallMolecule528
left: SmallMolecule681
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: coenzyme A
right: SmallMolecule652

Synthesis of CL
type: Pathway
data source: Provenance1
pathway component: PG and CDP-DAG are converted to CL by CRLS1
evidence: Evidence942
xref: RelationshipXref786
xref: UnificationXref10492
xref: UnificationXref10493
pathway order: PathwayStep928
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref22022
type: UnificationXref
id: 379777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379777

Stoichiometry1823
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 2.0

UnificationXref22023
type: UnificationXref
id: REACT_15932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15932.1

Stoichiometry1822
type: Stoichiometry
physical entity: Complex804
stoichiometric coefficient: 1.0

UnificationXref22020
type: UnificationXref
id: 379761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379761

Stoichiometry1821
type: Stoichiometry
physical entity: PhysicalEntity201
stoichiometric coefficient: 1.0

UnificationXref22021
type: UnificationXref
id: REACT_15998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15998.1

Stoichiometry1820
type: Stoichiometry
physical entity: Protein6027
stoichiometric coefficient: 1.0

UnificationXref22027
type: UnificationXref
id: 6267802
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267802

PI:PITPNB is transported from the ER membrane to the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence909
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10312
xref: UnificationXref10313
left: Complex499
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex500

UnificationXref22026
type: UnificationXref
id: B9G0A4
db: UniProt

PI is exchanged with PC by PITPNB
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence910
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10315
xref: UnificationXref10316
left: Complex500
left: SmallMolecule675
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule679
right: Complex501

UnificationXref22025
type: UnificationXref
id: 6267800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267800

UnificationXref22024
type: UnificationXref
id: Q2R1C1
db: UniProt

CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence907
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.8.2
xref: UnificationXref10298
xref: UnificationXref10299
left: SmallMolecule673
left: SmallMolecule674
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule253
right: SmallMolecule675

PC is hydrolyzed to 1-acyl LPC by PLA2[5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence914
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.1.4
xref: UnificationXref10326
xref: UnificationXref10327
left: Water
left: SmallMolecule652
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule680
right: SmallMolecule654

1-acyl LPC is acylated to PC by LPCAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence915
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10333
xref: UnificationXref10334
left: SmallMolecule680
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: coenzyme A
right: SmallMolecule652

UnificationXref22029
type: UnificationXref
id: 6267804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267804

PC:PITPNB is transported from the Golgi membrane to the ER membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence911
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10318
xref: UnificationXref10319
left: Complex501
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex502

UnificationXref22028
type: UnificationXref
id: Q2R1C2
db: UniProt

PC is exchanged with PI by PITPNB
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence912
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10320
xref: UnificationXref10321
left: SmallMolecule678
left: Complex502
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex499
right: SmallMolecule652

UnificationXref14730
type: UnificationXref
id: REACT_14009
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14009.2

Stoichiometry1836
type: Stoichiometry
physical entity: Complex807
stoichiometric coefficient: 1.0

UnificationXref14721
type: UnificationXref
id: 6266404
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266404

Stoichiometry1835
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

UnificationXref14720
type: UnificationXref
id: 6266403
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266403

Stoichiometry1838
type: Stoichiometry
physical entity: Protein6030
stoichiometric coefficient: 1.0

UnificationXref14723
type: UnificationXref
id: REACT_234619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234619.1

Stoichiometry1837
type: Stoichiometry
physical entity: PhysicalEntity202
stoichiometric coefficient: 1.0

UnificationXref14722
type: UnificationXref
id: 6266406
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266406

UnificationXref14725
type: UnificationXref
id: REACT_261959
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261959.1

Stoichiometry1839
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref14724
type: UnificationXref
id: 6279517
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279517

UnificationXref14727
type: UnificationXref
id: REACT_256527
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256527.1

UnificationXref14726
type: UnificationXref
id: 6279519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279519

UnificationXref14729
type: UnificationXref
id: 215573
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=215573

PTPMT1 dephosphorylates PGP to PG
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence934
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.27
xref: UnificationXref10453
xref: UnificationXref10454
left: Water
left: SmallMolecule694
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: SmallMolecule695

UnificationXref14728
type: UnificationXref
id: CHEBI:15367
db: ChEBI

PA is converted to CDP-DAG by CDS2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence933
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.41
xref: UnificationXref10433
xref: UnificationXref10434
left: SmallMolecule691
left: SmallMolecule690
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule692
right: SmallMolecule693

Stoichiometry1830
type: Stoichiometry
physical entity: PhysicalEntity201
stoichiometric coefficient: 1.0

UnificationXref22030
type: UnificationXref
id: 6267805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267805

UnificationXref22031
type: UnificationXref
id: 6267806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267806

Stoichiometry1832
type: Stoichiometry
physical entity: PCNA homotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

UnificationXref22032
type: UnificationXref
id: 6267808
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6267808

Stoichiometry1831
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref22033
type: UnificationXref
id: REACT_246649
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246649.1

Stoichiometry1834
type: Stoichiometry
physical entity: Complex800
stoichiometric coefficient: 1.0

UnificationXref22034
type: UnificationXref
id: 379706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379706

Stoichiometry1833
type: Stoichiometry
physical entity: Complex807
stoichiometric coefficient: 1.0

UnificationXref22036
type: UnificationXref
id: 379791
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379791

PE is converted to PS by PTDSS2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence921
conversion direction: LEFT_TO_RIGHT
EC number: 2
xref: UnificationXref10364
xref: UnificationXref10363
left: SmallMolecule662
left: SmallMolecule116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule657
right: SmallMolecule683

UnificationXref22035
type: UnificationXref
id: REACT_15829
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15829.2

1-acyl LPS is acylated to PS by LPSAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence923
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10371
xref: UnificationXref10372
left: SmallMolecule528
left: SmallMolecule684
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule683
right: coenzyme A

UnificationXref22038
type: UnificationXref
id: 379779
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379779

2-acyl LPS is acylated to PS by LPSAT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence924
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10377
xref: UnificationXref10376
left: SmallMolecule528
left: SmallMolecule685
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule683
right: coenzyme A

UnificationXref22037
type: UnificationXref
id: REACT_15748
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15748.1

PA is converted to CDP-DAG by CDS1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence926
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.41
xref: UnificationXref10390
xref: UnificationXref10389
left: SmallMolecule659
left: SmallMolecule530
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule340
right: SmallMolecule686

CDP-DAG is converted to PI by CDIPT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence927
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.8.11
xref: UnificationXref10397
xref: UnificationXref10398
left: SmallMolecule186
left: SmallMolecule686
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule678
right: SmallMolecule253

UnificationXref22039
type: UnificationXref
id: REACT_17148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17148.1

1-acyl LPI is acylated to PI by MBOAT7
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence929
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.51
xref: UnificationXref10406
xref: UnificationXref10405
left: SmallMolecule528
left: SmallMolecule687
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule678
right: coenzyme A

2-acyl LPI is acylated to PI by MBOAT7
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence930
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.52
xref: UnificationXref10411
xref: UnificationXref10410
left: SmallMolecule528
left: SmallMolecule688
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule678
right: coenzyme A

PC is transphosphatidylated to PG by PLD1-4/6
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence932
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.4.4
xref: UnificationXref10421
xref: UnificationXref10420
left: SmallMolecule511
left: SmallMolecule652
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule689
right: SmallMolecule229

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DQC3
data source: Provenance1
name: PAI-1
name: Q0DQC3
name: SERPINE1
name: Plasminogen activator inhibitor-1 precursor
name: Endothelial plasminogen activator inhibitor
xref: UnificationXref23610
feature: FragmentFeature7594
cellular location: GO_0031093
comment: Reactome DB_ID: 6271664
display name: PAI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9F9P1
data source: Provenance1
name: PAI-1
name: SERPINE1
name: Plasminogen activator inhibitor-1 precursor
name: B9F9P1
name: Endothelial plasminogen activator inhibitor
xref: UnificationXref23611
feature: FragmentFeature7595
cellular location: GO_0031093
comment: Reactome DB_ID: 6271666
display name: PAI

phospho-p-PLCG2
type: Protein
entity reference: Q10MY6
data source: Provenance1
xref: UnificationXref23603
feature: FragmentFeature7593
feature: ModificationFeature725
cellular location: GO_0005886
comment: Reactome DB_ID: 6261197

Homologues of SERPINE1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23612
cellular location: GO_0031093
comment: Reactome DB_ID: 6271667
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53Q32
data source: Provenance1
name: SERPINA1
name: Alpha-1-antitrypsin
xref: UnificationXref23614
feature: FragmentFeature7596
cellular location: GO_0031093
comment: Reactome DB_ID: 6271670
display name: Q53Q32

Stoichiometry1730
type: Stoichiometry
physical entity: Protein5940
stoichiometric coefficient: 1.0

Stoichiometry1731
type: Stoichiometry
physical entity: Complex783
stoichiometric coefficient: 1.0

Stoichiometry1734
type: Stoichiometry
physical entity: Protein5945
stoichiometric coefficient: 1.0

Stoichiometry1735
type: Stoichiometry
physical entity: Protein5946
stoichiometric coefficient: 1.0

Stoichiometry1732
type: Stoichiometry
physical entity: Protein5943
stoichiometric coefficient: 1.0

Stoichiometry1733
type: Stoichiometry
physical entity: Protein5944
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53MD3
data source: Provenance1
name: SERPINF2
name: Alpha-2-antiplasmin
xref: UnificationXref23618
feature: FragmentFeature7598
cellular location: GO_0031093
comment: Reactome DB_ID: 6271674
display name: Q53MD3

Stoichiometry1738
type: Stoichiometry
physical entity: Protein5952
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/17555535
type: PublicationXref
id: 17555535
author: Sherwood, MW
author: Burgoyne, RD
author: Dolman, NJ
author: Haynes, LP
db: Pubmed
title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta
source: Traffic 8:1080-92
year: 2007

Plasma protease C1 inhibitor precursor
type: Protein
entity reference: Q7XMK1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: C1 Inh
name: Q7XMK1
name: SERPING1
xref: UnificationXref23616
feature: FragmentFeature7597
cellular location: GO_0031093
comment: Reactome DB_ID: 6271673
display name: C1Inh

Stoichiometry1739
type: Stoichiometry
physical entity: Protein5932
stoichiometric coefficient: 1.0

Stoichiometry1736
type: Stoichiometry
physical entity: Protein5949
stoichiometric coefficient: 1.0

Stoichiometry1737
type: Stoichiometry
physical entity: Complex782
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q94JJ0
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q94JJ0
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23621
feature: FragmentFeature7601
cellular location: GO_0031093
comment: Reactome DB_ID: 6271677
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q40677
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
name: Q40677
xref: UnificationXref23620
feature: FragmentFeature7600
cellular location: GO_0031093
comment: Reactome DB_ID: 6271676
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5N726
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q5N726
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23619
feature: FragmentFeature7599
cellular location: GO_0031093
comment: Reactome DB_ID: 6271675
display name: ALDOA

Homologues of ALDOA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23626
cellular location: GO_0031093
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271682

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6YPF1
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q6YPF1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23622
feature: FragmentFeature7602
cellular location: GO_0031093
comment: Reactome DB_ID: 6271678
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference1260
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
name: OS12T0169600-01
xref: UnificationXref23623
feature: FragmentFeature7603
cellular location: GO_0031093
comment: Reactome DB_ID: 6271679
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P17784
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: P17784
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23624
feature: FragmentFeature7604
cellular location: GO_0031093
comment: Reactome DB_ID: 6271680
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5N725
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q5N725
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23625
feature: FragmentFeature7605
cellular location: GO_0031093
comment: Reactome DB_ID: 6271681
display name: ALDOA

Neurotransmitter Release Cycle
type: Pathway
data source: Provenance1
pathway component: REACT 211253.2
pathway component: REACT 226844.2
evidence: Evidence272
xref: UnificationXref3246
xref: UnificationXref3245
xref: RelationshipXref118
pathway order: PathwayStep263
pathway order: PathwayStep258
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UniProt:Q69J27
type: ProteinReference
xref: UnificationXref19329
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1720
type: Stoichiometry
physical entity: Complex779
stoichiometric coefficient: 1.0

Stoichiometry1721
type: Stoichiometry
physical entity: PhysicalEntity181
stoichiometric coefficient: 1.0

Stoichiometry1722
type: Stoichiometry
physical entity: Protein5932
stoichiometric coefficient: 1.0

Stoichiometry1723
type: Stoichiometry
physical entity: Complex780
stoichiometric coefficient: 1.0

Stoichiometry1724
type: Stoichiometry
physical entity: PhysicalEntity16
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53Q32
data source: Provenance1
name: SERPINA1
name: Alpha-1-antitrypsin
xref: UnificationXref23628
feature: FragmentFeature7606
cellular location: GO_0005576
comment: Reactome DB_ID: 6271687
display name: Q53Q32

Stoichiometry1725
type: Stoichiometry
physical entity: Protein5935
stoichiometric coefficient: 1.0

Stoichiometry1726
type: Stoichiometry
physical entity: RPA heterotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

Homologues of ALDOA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23637
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271695

Stoichiometry1727
type: Stoichiometry
physical entity: Protein5938
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53MD3
data source: Provenance1
name: SERPINF2
name: Alpha-2-antiplasmin
xref: UnificationXref23629
feature: FragmentFeature7607
cellular location: GO_0005576
comment: Reactome DB_ID: 6261671
display name: Q53MD3

Stoichiometry1728
type: Stoichiometry
physical entity: Protein5939
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q40677
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
name: Q40677
xref: UnificationXref23631
feature: FragmentFeature7609
cellular location: GO_0005576
comment: Reactome DB_ID: 6271689
display name: ALDOA

Stoichiometry1729
type: Stoichiometry
physical entity: PhysicalEntity16
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5N726
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q5N726
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23630
feature: FragmentFeature7608
cellular location: GO_0005576
comment: Reactome DB_ID: 6271688
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6YPF1
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q6YPF1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23633
feature: FragmentFeature7611
cellular location: GO_0005576
comment: Reactome DB_ID: 6271691
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q94JJ0
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q94JJ0
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23632
feature: FragmentFeature7610
cellular location: GO_0005576
comment: Reactome DB_ID: 6271690
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5N725
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q5N725
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23636
feature: FragmentFeature7614
cellular location: GO_0005576
comment: Reactome DB_ID: 6271694
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference1260
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
name: OS12T0169600-01
xref: UnificationXref23634
feature: FragmentFeature7612
cellular location: GO_0005576
comment: Reactome DB_ID: 6271692
display name: ALDOA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P17784
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: P17784
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref23635
feature: FragmentFeature7613
cellular location: GO_0005576
comment: Reactome DB_ID: 6271693
display name: ALDOA

Stoichiometry1760
type: Stoichiometry
physical entity: Protein5960
stoichiometric coefficient: 1.0

UniProt:B7FA99
type: ProteinReference
xref: UnificationXref13740
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1756
type: Stoichiometry
physical entity: Complex785
stoichiometric coefficient: 1.0

Stoichiometry1757
type: Stoichiometry
physical entity: RPA heterotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

Stoichiometry1754
type: Stoichiometry
physical entity: Protein5935
stoichiometric coefficient: 1.0

UnificationXref14809
type: UnificationXref
id: 6266605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266605

Stoichiometry1755
type: Stoichiometry
physical entity: PhysicalEntity189
stoichiometric coefficient: 1.0

Stoichiometry1752
type: Stoichiometry
physical entity: PhysicalEntity16
stoichiometric coefficient: 1.0

UnificationXref14807
type: UnificationXref
id: 6266604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266604

Stoichiometry1753
type: Stoichiometry
physical entity: Complex779
stoichiometric coefficient: 1.0

UnificationXref14808
type: UnificationXref
id: B9FXJ6
db: UniProt

UniProt:Q94IW5
type: ProteinReference
xref: UnificationXref14802
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1750
type: Stoichiometry
physical entity: Complex785
stoichiometric coefficient: 1.0

UnificationXref14805
type: UnificationXref
id: 6266603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266603

Stoichiometry1751
type: Stoichiometry
physical entity: Protein5932
stoichiometric coefficient: 1.0

UnificationXref14806
type: UnificationXref
id: Q8GSQ1
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0IUU4
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: Q0IUU4
xref: UnificationXref23649
feature: FragmentFeature7621
cellular location: GO_0005576
comment: Reactome DB_ID: 6271736
display name: CALM1

UnificationXref14803
type: UnificationXref
id: 6266602
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266602

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0IQB6
data source: Provenance1
name: Q0IQB6
name: CALM_HUMAN
name: Calmodulin
xref: UnificationXref23648
feature: FragmentFeature7620
cellular location: GO_0005576
comment: Reactome DB_ID: 6271735
display name: CALM1

UnificationXref14804
type: UnificationXref
id: Q2R6X3
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6F332
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: Q6F332
xref: UnificationXref23647
feature: FragmentFeature7619
cellular location: GO_0005576
comment: Reactome DB_ID: 6271734
display name: CALM1

UnificationXref14801
type: UnificationXref
id: 6266601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266601

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0JNS6
data source: Provenance1
name: Q0JNS6
name: CALM_HUMAN
name: Calmodulin
xref: UnificationXref23646
feature: FragmentFeature7618
cellular location: GO_0005576
comment: Reactome DB_ID: 6271733
display name: CALM1

UnificationXref14802
type: UnificationXref
id: Q94IW5
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0JNL7
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: Q0JNL7
xref: UnificationXref23645
feature: FragmentFeature7617
cellular location: GO_0005576
comment: Reactome DB_ID: 6271732
display name: CALM1

Homologues of CALM1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23651
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271738

UnificationXref14800
type: UnificationXref
id: B9FC23
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9AWU6
data source: Provenance1
name: WD repeat-containing protein 1
name: WDR1_HUMAN
name: Q9AWU6
xref: UnificationXref23643
feature: FragmentFeature7616
cellular location: GO_0005829
comment: Reactome DB_ID: 6271713
display name: WDR1

Stoichiometry1758
type: Stoichiometry
physical entity: Complex782
stoichiometric coefficient: 1.0

Glucuronidation
type: Pathway
data source: Provenance1
pathway component: REACT 262748.1
evidence: Evidence1381
xref: UnificationXref15169
xref: RelationshipXref1319
xref: UnificationXref15170
pathway order: PathwayStep1366
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7XMK1
data source: Provenance1
name: plasma protease C1 inhibitor
name: Q7XMK1
name: SERPING1
xref: UnificationXref23638
feature: FragmentFeature7615
cellular location: GO_0005576
comment: Reactome DB_ID: 6271696
display name: C1Inh

Stoichiometry1759
type: Stoichiometry
physical entity: Protein5952
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q948R0
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: Q948R0
xref: UnificationXref23650
feature: FragmentFeature7622
cellular location: GO_0005576
comment: Reactome DB_ID: 6271737
display name: CALM1

UniProt:Q6EUS4
type: ProteinReference
xref: UnificationXref17557
organism: http://identifiers.org/taxonomy/4530

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9AWU6
data source: Provenance1
name: WD repeat-containing protein 1
name: WDR1_HUMAN
name: Q9AWU6
xref: UnificationXref23652
feature: FragmentFeature7623
cellular location: GO_0005576
comment: Reactome DB_ID: 6271739
display name: WDR1

UniProt:Q6EUS6
type: ProteinReference
xref: UnificationXref7049
organism: http://identifiers.org/taxonomy/4530

UniProt:Q94J90
type: ProteinReference
xref: UnificationXref12873
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1743
type: Stoichiometry
physical entity: Protein5935
stoichiometric coefficient: 1.0

Stoichiometry1744
type: Stoichiometry
physical entity: RPA heterotrimer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

Homologues of SOD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23659
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271746

Stoichiometry1745
type: Stoichiometry
physical entity: Complex782
stoichiometric coefficient: 1.0

Stoichiometry1746
type: Stoichiometry
physical entity: Protein5952
stoichiometric coefficient: 1.0

UnificationXref14816
type: UnificationXref
id: Q10FR4
db: UniProt

Stoichiometry1740
type: Stoichiometry
physical entity: PhysicalEntity188
stoichiometric coefficient: 1.0

UnificationXref14817
type: UnificationXref
id: 6266609
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266609

Stoichiometry1741
type: Stoichiometry
physical entity: PhysicalEntity16
stoichiometric coefficient: 1.0

UnificationXref14818
type: UnificationXref
id: Q7EZ51
db: UniProt

Stoichiometry1742
type: Stoichiometry
physical entity: Complex779
stoichiometric coefficient: 1.0

UnificationXref14819
type: UnificationXref
id: 6266610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266610

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28757
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: P28757
xref: UnificationXref23658
feature: FragmentFeature7629
cellular location: GO_0005576
comment: Reactome DB_ID: 6271745
display name: SOD1

UnificationXref14812
type: UnificationXref
id: B9G7R9
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10PW4
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: Q10PW4
xref: UnificationXref23657
feature: FragmentFeature7628
cellular location: GO_0005576
comment: Reactome DB_ID: 6271744
display name: SOD1

UnificationXref14813
type: UnificationXref
id: 6266607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266607

Q10DR8
type: Protein
entity reference: Q10DR8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23664
feature: FragmentFeature7630
cellular location: GO_0005829
comment: Reactome DB_ID: 6271751
display name: CAP1

UnificationXref14814
type: UnificationXref
id: Q7XIL5
db: UniProt

Homologues of CAP1
type: Protein
data source: Provenance1
member physical entity: Q53K24
member physical entity: Q10DR8
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23669
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271756

UnificationXref14815
type: UnificationXref
id: 6266608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266608

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DTX5
data source: Provenance1
name: Q0DTX5
name: Superoxide dismutase (Cu-Zn)
xref: UnificationXref23654
feature: FragmentFeature7625
cellular location: GO_0005576
comment: Reactome DB_ID: 6271741
display name: SOD1

Stoichiometry1747
type: Stoichiometry
physical entity: Protein5955
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DRV6
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: Q0DRV6
xref: UnificationXref23653
feature: FragmentFeature7624
cellular location: GO_0005576
comment: Reactome DB_ID: 6271740
display name: SOD1

Stoichiometry1748
type: Stoichiometry
physical entity: Protein5959
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10PW3
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: Q10PW3
xref: UnificationXref23656
feature: FragmentFeature7627
cellular location: GO_0005576
comment: Reactome DB_ID: 6271743
display name: SOD1

Stoichiometry1749
type: Stoichiometry
physical entity: Complex784
stoichiometric coefficient: 1.0

UnificationXref14810
type: UnificationXref
id: Q0J185
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P93407
data source: Provenance1
name: P93407
name: Superoxide dismutase (Cu-Zn)
xref: UnificationXref23655
feature: FragmentFeature7626
cellular location: GO_0005576
comment: Reactome DB_ID: 6271742
display name: SOD1

UnificationXref14811
type: UnificationXref
id: 6266606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266606

Stoichiometry1781
type: Stoichiometry
physical entity: Complex788
stoichiometric coefficient: 1.0

UniProt:Q69IL0
type: ProteinReference
xref: UnificationXref604
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1782
type: Stoichiometry
physical entity: PhysicalEntity197
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/1703535
type: PublicationXref
id: 1703535
author: Purdue, PE
author: Danpure, CJ
author: Takada, Y
db: Pubmed
title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
source: J Cell Biol 111:2341-51
year: 1990

Stoichiometry1780
type: Stoichiometry
physical entity: Complex782
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/11863375
type: PublicationXref
id: 11863375
author: Yang, RZ
author: Shuldiner, AR
author: Gong, DW
author: Blaileanu, G
author: Hansen, BC
db: Pubmed
title: cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
source: Genomics 79:445-50
year: 2002

UniProt:Q6EUP4
type: ProteinReference
xref: UnificationXref447
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1775
type: Stoichiometry
physical entity: Protein6010
stoichiometric coefficient: 1.0

Stoichiometry1774
type: Stoichiometry
physical entity: Protein6004
stoichiometric coefficient: 1.0

Stoichiometry1773
type: Stoichiometry
physical entity: PhysicalEntity193
stoichiometric coefficient: 1.0

Stoichiometry1772
type: Stoichiometry
physical entity: Complex788
stoichiometric coefficient: 1.0

Stoichiometry1779
type: Stoichiometry
physical entity: Protein6017
stoichiometric coefficient: 1.0

Stoichiometry1778
type: Stoichiometry
physical entity: Protein6014
stoichiometric coefficient: 1.0

Stoichiometry1777
type: Stoichiometry
physical entity: Complex785
stoichiometric coefficient: 1.0

Stoichiometry1776
type: Stoichiometry
physical entity: Protein5935
stoichiometric coefficient: 1.0

UniProt:Q94IZ2
type: ProteinReference
xref: UnificationXref17537
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1770
type: Stoichiometry
physical entity: Protein6002
stoichiometric coefficient: 1.0

Stoichiometry1771
type: Stoichiometry
physical entity: Protein6003
stoichiometric coefficient: 1.0

UniProt:Q6EUQ1
type: ProteinReference
xref: UnificationXref22971
organism: http://identifiers.org/taxonomy/4530

abacavir [ChEBI:421707]
type: SmallMoleculeReference
name: abacavir
name: {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
xref: UnificationXref15648

UniProt:Q6EUQ9
type: ProteinReference
xref: UnificationXref5808
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1769
type: Stoichiometry
physical entity: Protein5999
stoichiometric coefficient: 1.0

UniProt:Q6EUQ7
type: ProteinReference
xref: UnificationXref18219
organism: http://identifiers.org/taxonomy/4530

Stoichiometry1762
type: Stoichiometry
physical entity: Protein5975
stoichiometric coefficient: 1.0

Stoichiometry1761
type: Stoichiometry
physical entity: Protein5965
stoichiometric coefficient: 1.0

Stoichiometry1764
type: Stoichiometry
physical entity: Protein5983
stoichiometric coefficient: 1.0

Stoichiometry1763
type: Stoichiometry
physical entity: Protein5976
stoichiometric coefficient: 1.0

Stoichiometry1766
type: Stoichiometry
physical entity: Protein5991
stoichiometric coefficient: 1.0

Stoichiometry1765
type: Stoichiometry
physical entity: Protein5987
stoichiometric coefficient: 1.0

Stoichiometry1768
type: Stoichiometry
physical entity: Protein5996
stoichiometric coefficient: 1.0

Stoichiometry1767
type: Stoichiometry
physical entity: Protein5995
stoichiometric coefficient: 1.0

UniProt:Q6EUN0
type: ProteinReference
xref: UnificationXref11729
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/11435118
type: PublicationXref
id: 11435118
author: Timm, DE
author: Harris, RA
author: Dorocke, JA
author: Baker, LJ
db: Pubmed
title: The crystal structure of yeast thiamin pyrophosphokinase
source: Structure 9:539-46
year: 2001

Homologues of STK24(1-313)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23582
cellular location: GO_0005654
comment: Reactome DB_ID: 6267241
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7EZ29
data source: Provenance1
name: MST3 fragment (1-313)
name: STK24(1-313)
xref: UnificationXref23579
feature: FragmentFeature7582
cellular location: GO_0005654
comment: Reactome DB_ID: 6267238
display name: Q7EZ29

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7EZ28
data source: Provenance1
name: MST3 fragment (1-313)
name: STK24(1-313)
xref: UnificationXref23575
feature: FragmentFeature7580
cellular location: GO_0005829
comment: Reactome DB_ID: 6267231
display name: Q7EZ28

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FXF1
data source: Provenance1
name: MST3 fragment (1-313)
name: STK24(1-313)
xref: UnificationXref23577
feature: FragmentFeature7581
cellular location: GO_0005829
comment: Reactome DB_ID: 6267232
display name: B9FXF1

Stoichiometry1799
type: Stoichiometry
physical entity: Protein6026
stoichiometric coefficient: 1.0

Stoichiometry1798
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 2.0

Stoichiometry1797
type: Stoichiometry
physical entity: PhysicalEntity198
stoichiometric coefficient: 1.0

Stoichiometry1796
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 2.0

Stoichiometry1795
type: Stoichiometry
physical entity: Complex796
stoichiometric coefficient: 1.0

Stoichiometry1794
type: Stoichiometry
physical entity: PhysicalEntity198
stoichiometric coefficient: 1.0

Stoichiometry1790
type: Stoichiometry
physical entity: PhysicalEntity181
stoichiometric coefficient: 1.0

Stoichiometry1791
type: Stoichiometry
physical entity: Protein6026
stoichiometric coefficient: 1.0

Stoichiometry1792
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 2.0

Stoichiometry1793
type: Stoichiometry
physical entity: Protein6027
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/10783391
type: PublicationXref
id: 10783391
author: Gabel, CA
author: Schulte, GK
author: Hoth, LR
author: Chelvanayagam, G
author: Chrunyk, BA
author: Geoghegan, KF
author: Coggan, M
author: Easteal, S
author: Kamath, AV
author: Board, PG
author: Jermiin, LS
author: Pandit, J
author: Rosner, MH
author: Perregaux, DE
author: Danley, DE
author: Griffor, MC
db: Pubmed
title: Identification, characterization, and crystal structure of the Omega class glutathione transferases
source: J Biol Chem 275:24798-806
year: 2000

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

phospho-p-PLCG2
type: Protein
entity reference: Q6Z3Y9
data source: Provenance1
xref: UnificationXref23597
feature: ModificationFeature719
feature: FragmentFeature7587
cellular location: GO_0005886
comment: Reactome DB_ID: 6261185

phospho-p-PLCG2
type: Protein
entity reference: B9F7R4
data source: Provenance1
xref: UnificationXref23596
feature: ModificationFeature718
feature: FragmentFeature7586
cellular location: GO_0005886
comment: Reactome DB_ID: 6261183

Post-Elongation Processing of Intronless pre-mRNA
type: Pathway
data source: Provenance1
pathway component: REACT 249058.1
evidence: Evidence2079
xref: UnificationXref22611
xref: UnificationXref22610
pathway order: PathwayStep1971
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FXF1
data source: Provenance1
name: MST3 fragment (1-313)
name: STK24(1-313)
xref: UnificationXref23581
feature: FragmentFeature7584
cellular location: GO_0005654
comment: Reactome DB_ID: 6267240
display name: B9FXF1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7EZ28
data source: Provenance1
name: MST3 fragment (1-313)
name: STK24(1-313)
xref: UnificationXref23580
feature: FragmentFeature7583
cellular location: GO_0005654
comment: Reactome DB_ID: 6267239
display name: Q7EZ28

phospho-p-PLCG2
type: Protein
entity reference: UniProt:Q2QNK2
data source: Provenance1
xref: UnificationXref23595
feature: ModificationFeature717
feature: FragmentFeature7585
cellular location: GO_0005886
comment: Reactome DB_ID: 6261181

Homologues of p-PLCG2
type: Protein
data source: Provenance1
member physical entity: phospho-p-PLCG2
xref: UnificationXref23604
cellular location: GO_0005886
comment: Reactome DB_ID: 6261198
comment: Converted from EntitySet in Reactome

phospho-p-PLCG2
type: Protein
entity reference: Q75IL8
data source: Provenance1
xref: UnificationXref23599
feature: ModificationFeature721
feature: FragmentFeature7589
cellular location: GO_0005886
comment: Reactome DB_ID: 6261189

phospho-p-PLCG2
type: Protein
entity reference: Q0IML8
data source: Provenance1
xref: UnificationXref23600
feature: FragmentFeature7590
feature: ModificationFeature722
cellular location: GO_0005886
comment: Reactome DB_ID: 6261191

phospho-p-PLCG2
type: Protein
entity reference: Q0DST2
data source: Provenance1
xref: UnificationXref23601
feature: FragmentFeature7591
feature: ModificationFeature723
cellular location: GO_0005886
comment: Reactome DB_ID: 6261193

phospho-p-PLCG2
type: Protein
entity reference: Q10MY5
data source: Provenance1
xref: UnificationXref23602
feature: FragmentFeature7592
feature: ModificationFeature724
cellular location: GO_0005886
comment: Reactome DB_ID: 6261195

phospho-p-PLCG2
type: Protein
entity reference: UniProt:Q2QNK1
data source: Provenance1
xref: UnificationXref23598
feature: ModificationFeature720
feature: FragmentFeature7588
cellular location: GO_0005886
comment: Reactome DB_ID: 6261187

Stoichiometry1788
type: Stoichiometry
physical entity: Complex793
stoichiometric coefficient: 1.0

Stoichiometry1787
type: Stoichiometry
physical entity: Protein6023
stoichiometric coefficient: 1.0

Stoichiometry1789
type: Stoichiometry
physical entity: Complex794
stoichiometric coefficient: 1.0

Stoichiometry1784
type: Stoichiometry
physical entity: PhysicalEntity46
stoichiometric coefficient: 1.0

Stoichiometry1783
type: Stoichiometry
physical entity: Complex788
stoichiometric coefficient: 1.0

Stoichiometry1786
type: Stoichiometry
physical entity: PhysicalEntity46
stoichiometric coefficient: 1.0

Stoichiometry1785
type: Stoichiometry
physical entity: Protein6022
stoichiometric coefficient: 1.0

UniProt:Q69J93
type: ProteinReference
xref: UnificationXref13368
organism: http://identifiers.org/taxonomy/4530

Cohesin Loading onto Chromatin
type: Pathway
data source: Provenance1
pathway component: Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
evidence: Evidence67
xref: UnificationXref1547
xref: UnificationXref1548
pathway order: PathwayStep64
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

UniProt:Q69IY8
type: ProteinReference
xref: UnificationXref21178
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

http://identifiers.org/pubmed/1968462
type: PublicationXref
id: 1968462
author: Edwards, PA
author: Kutsunai, SY
author: Wilkin, DJ
db: Pubmed
title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester
source: J Biol Chem 265:4607-14
year: 1990

3-Ureidoisobutyrate
type: SmallMoleculeReference
name: 3-ureidoisobutyric acid
name: ChEBI:1670 3-ureidoisobutyric acid
xref: UnificationXref12918

UniProt:Q94JA2
type: ProteinReference
xref: UnificationXref7015
organism: http://identifiers.org/taxonomy/4530

Homologues of CAP1
type: Protein
data source: Provenance1
member physical entity: Q10DR8
member physical entity: Q53K24
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23676
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6271764

Q10DR8
type: Protein
entity reference: Q10DR8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23673
feature: FragmentFeature7634
cellular location: GO_0005576
comment: Reactome DB_ID: 6271761
display name: CAP1

Q53K24
type: Protein
entity reference: Q53K24
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23674
feature: FragmentFeature7635
cellular location: GO_0005576
comment: Reactome DB_ID: 6271762
display name: CAP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DP12
data source: Provenance1
name: Q0DP12
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23675
feature: FragmentFeature7636
cellular location: GO_0005576
comment: Reactome DB_ID: 6271763
display name: CAP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84TB3
data source: Provenance1
name: COF1_HUMAN
name: Cofilin-1
name: Q84TB3
xref: UnificationXref23677
feature: FragmentFeature7637
cellular location: GO_0005576
comment: Reactome DB_ID: 6271765
display name: CFL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q651B0
data source: Provenance1
name: Q651B0
name: Cyp A protein
xref: UnificationXref23678
feature: FragmentFeature7638
cellular location: GO_0005576
comment: Reactome DB_ID: 6271766
display name: PPIA

Homologues of HSPA5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q6L590
xref: UnificationXref23691
cellular location: GO_0005576
comment: Reactome DB_ID: 6267224
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FIX9
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: B9FIX9
xref: UnificationXref23682
feature: FragmentFeature7639
cellular location: GO_0005576
comment: Reactome DB_ID: 6267215
display name: HSPA5

UnificationXref10580
type: UnificationXref
id: REACT_245502
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245502.1

UnificationXref10581
type: UnificationXref
id: 6275994
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275994

UnificationXref10582
type: UnificationXref
id: 6275996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275996

UnificationXref10583
type: UnificationXref
id: 6275999
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DP12
data source: Provenance1
name: Q0DP12
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23668
feature: FragmentFeature7632
cellular location: GO_0005829
comment: Reactome DB_ID: 6271755
display name: CAP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q651B0
data source: Provenance1
name: CypA protein
name: Q651B0
xref: UnificationXref23671
feature: FragmentFeature7633
cellular location: GO_0005829
comment: Reactome DB_ID: 6271759
display name: PPIA

UnificationXref10589
type: UnificationXref
id: 1806159
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806159

UnificationXref10588
type: UnificationXref
id: CHEBI:17283
db: ChEBI

UnificationXref10585
type: UnificationXref
id: 6276003
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276003

UnificationXref10584
type: UnificationXref
id: 6276002
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276002

UnificationXref10587
type: UnificationXref
id: REACT_211095
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211095.2

UnificationXref10586
type: UnificationXref
id: 6276014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276014

Q53K24
type: Protein
entity reference: Q53K24
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylyl cyclase-associated protein 1
xref: UnificationXref23666
feature: FragmentFeature7631
cellular location: GO_0005829
comment: Reactome DB_ID: 6271753
display name: CAP1

http://identifiers.org/pubmed/10092647
type: PublicationXref
id: 10092647
author: Wang, X
author: Nowatzke, W
author: Ramanadham, S
author: Ma, Z
author: Turk, J
db: Pubmed
title: Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1
source: J Biol Chem 274:9607-16
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference3777
data source: Provenance1
name: OS01T0517900-00
name: 78 kDa glucose-regulated protein
xref: UnificationXref23688
feature: FragmentFeature7645
cellular location: GO_0005576
comment: Reactome DB_ID: 6267221
display name: HSPA5

http://identifiers.org/pubmed/17170135
type: PublicationXref
id: 17170135
author: Li, JL
author: Gimeno, RE
author: Li, D
author: Tobin, JF
author: Cao, J
db: Pubmed
title: Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
source: Proc Natl Acad Sci U S A 103:19695-700
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53RJ5
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: Q53RJ5
xref: UnificationXref23689
feature: FragmentFeature7646
cellular location: GO_0005576
comment: Reactome DB_ID: 6267222
display name: HSPA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6Z058
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: Q6Z058
xref: UnificationXref23686
feature: FragmentFeature7643
cellular location: GO_0005576
comment: Reactome DB_ID: 6267219
display name: HSPA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FP77
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: B9FP77
xref: UnificationXref23687
feature: FragmentFeature7644
cellular location: GO_0005576
comment: Reactome DB_ID: 6267220
display name: HSPA5

Homologues of RAD51C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23706
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273465

Q6L590
type: Protein
entity reference: Q6L590
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 78 kDa glucose-regulated protein
xref: UnificationXref23690
feature: FragmentFeature7647
cellular location: GO_0005576
comment: Reactome DB_ID: 6267223
display name: HSPA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q60F40
data source: Provenance1
name: RAD51L1
name: RA51B_HUMAN
name: DNA repair protein RAD51 homolog 2
name: Q60F40
xref: UnificationXref23701
feature: FragmentFeature7648
cellular location: GO_0005654
comment: Reactome DB_ID: 6273459
display name: RAD51B

UnificationXref10593
type: UnificationXref
id: Q5KQK1
db: UniProt

UnificationXref10594
type: UnificationXref
id: 6263203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263203

UnificationXref10591
type: UnificationXref
id: Q6UUD9
db: UniProt

UnificationXref10592
type: UnificationXref
id: 6263200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263200

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6Z7B0
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: Q6Z7B0
xref: UnificationXref23684
feature: FragmentFeature7641
cellular location: GO_0005576
comment: Reactome DB_ID: 6267217
display name: HSPA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q75HQ0
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: Q75HQ0
xref: UnificationXref23685
feature: FragmentFeature7642
cellular location: GO_0005576
comment: Reactome DB_ID: 6267218
display name: HSPA5

UnificationXref10590
type: UnificationXref
id: REACT_121538
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121538.1

UniProt:Q69IU4
type: ProteinReference
xref: UnificationXref8302
organism: http://identifiers.org/taxonomy/4530

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FB52
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: B9FB52
xref: UnificationXref23683
feature: FragmentFeature7640
cellular location: GO_0005576
comment: Reactome DB_ID: 6267216
display name: HSPA5

UnificationXref10599
type: UnificationXref
id: Q0DWT3
db: UniProt

UnificationXref10598
type: UnificationXref
id: 6275950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275950

UnificationXref10597
type: UnificationXref
id: 6263206
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263206

UnificationXref10596
type: UnificationXref
id: 6263205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6263205

http://identifiers.org/pubmed/10371034
type: PublicationXref
id: 10371034
author: Rüegsegger, U
author: Wahle, E
db: Pubmed
title: 3'-End processing of pre-mRNA in eukaryotes.
source: FEMS Microbiol Rev 23:277-95
year: 1999

UnificationXref10595
type: UnificationXref
id: Q6UU97
db: UniProt

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2RAD9
data source: Provenance1
name: Histone H3.3 with dimethylated lysine9 (H3K9)
name: Me2K-10-H3F3A
xref: UnificationXref23734
feature: ModificationFeature727
feature: FragmentFeature7655
cellular location: GO_0005654
comment: Reactome DB_ID: 6268954
display name: Q2RAD9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference3107
data source: Provenance1
name: Histone H3.3 with dimethylated lysine9 (H3K9)
name: OS04T0450800-01
xref: UnificationXref23735
feature: FragmentFeature7656
feature: ModificationFeature728
cellular location: GO_0005654
comment: Reactome DB_ID: 6268956
display name: Me2K-10-H3F3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8H358
data source: Provenance1
name: F-actin-capping protein subunit alpha-1
name: Q8H358
name: CAZA1_HUMAN
xref: UnificationXref23725
feature: FragmentFeature7652
cellular location: GO_0005829
comment: Reactome DB_ID: 6272274
display name: CAPZA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q75M66
data source: Provenance1
name: Q75M66
name: CAPZB_HUMAN
name: F-actin-capping protein subunit beta
xref: UnificationXref23728
feature: FragmentFeature7653
cellular location: GO_0005829
comment: Reactome DB_ID: 6272278
display name: CAPZB

Homologues of Me2K-10-H3F3A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23736
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6268957

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference3105
data source: Provenance1
name: Histone H3.3 with dimethylated lysine9 (H3K9)
name: OS04T0450800-02
xref: UnificationXref23733
feature: ModificationFeature726
feature: FragmentFeature7654
cellular location: GO_0005654
comment: Reactome DB_ID: 6268952
display name: Me2K-10-H3F3A

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9EXP4
data source: Provenance1
name: DNA repair protein RAD51 homolog 3
name: (R51H3) (RAD51-like protein 2)
name: B9EXP4
xref: UnificationXref23703
feature: FragmentFeature7649
cellular location: GO_0005654
comment: Reactome DB_ID: 6273462
display name: RAD51C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9AWX8
data source: Provenance1
name: Q9AWX8
name: DNA repair protein RAD51 homolog 3
name: (R51H3) (RAD51-like protein 2)
xref: UnificationXref23705
feature: FragmentFeature7650
cellular location: GO_0005654
comment: Reactome DB_ID: 6273464
display name: RAD51C

Homologues of CAPZA1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23726
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6272275

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0D701
data source: Provenance1
name: F-actin-capping protein subunit alpha-1
name: Q0D701
name: CAZA1_HUMAN
xref: UnificationXref23723
feature: FragmentFeature7651
cellular location: GO_0005829
comment: Reactome DB_ID: 6272273
display name: CAPZA1

http://identifiers.org/pubmed/21540551
type: PublicationXref
id: 21540551
author: Matejas, V
author: Kispert, A
author: Casarin, A
author: Faul, C
author: Pertegato, V
author: Akman, S
author: Kusakabe, T
author: Wang, S
author: Santos-Ocaña, C
author: Krick, S
author: Doimo, M
author: Hildebrandt, F
author: Chernin, G
author: Vega-Warner, V
author: McLaughlin, HM
author: Nürnberg, G
author: Navas, P
author: Chaki, M
author: Schoeb, DS
author: Becker, C
author: Saisawat, P
author: Heeringa, SF
author: Varpizen, S
author: Prokisch, H
author: Wiggins, RC
author: Nürnberg, P
author: Beissert, A
author: Zhou, W
author: Bakkaloglu, A
author: Ji, Z
author: Xie, LX
author: Hinkes, B
author: Bakkaloglu, SA
author: Salviati, L
author: Reiser, J
author: Vlangos, CN
author: Mir, S
author: Airik, R
author: Topaloglu, R
author: Sloan, AJ
author: Rötig, A
author: Trevisson, E
author: Gbadegesin, R
author: Raphael, Y
author: Zenker, M
author: Clarke, CF
author: Ozaltin, F
author: Soliman, NA
author: Müller, D
author: Berdeli, A
author: Ashraf, S
author: Killen, PD
author: Mundel, P
author: Hurd, TW
author: Giorgi, G
author: Ovunc, B
db: Pubmed
title: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
source: J Clin Invest 121:2013-24
year: 2011

JHD2C_HUMAN
type: Protein
entity reference: ProteinReference4508
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: OS02T0109400-00
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
xref: UnificationXref23752
feature: FragmentFeature7664
cellular location: GO_0005654
comment: Reactome DB_ID: 6273648
display name: JMJD1C

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

JHD2C_HUMAN
type: Protein
entity reference: Q10LJ3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
name: Q10LJ3
xref: UnificationXref23748
feature: FragmentFeature7662
cellular location: GO_0005654
comment: Reactome DB_ID: 6273643
display name: JMJD1C

JHD2C_HUMAN
type: Protein
entity reference: Q6K7N9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q6K7N9
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
xref: UnificationXref23750
feature: FragmentFeature7663
cellular location: GO_0005654
comment: Reactome DB_ID: 6273645
display name: JMJD1C

JHD2C_HUMAN
type: Protein
entity reference: B9F4N3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: B9F4N3
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
xref: UnificationXref23744
feature: FragmentFeature7660
cellular location: GO_0005654
comment: Reactome DB_ID: 6273637
display name: JMJD1C

JHD2C_HUMAN
type: Protein
entity reference: Q0DR01
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
name: Q0DR01
xref: UnificationXref23746
feature: FragmentFeature7661
cellular location: GO_0005654
comment: Reactome DB_ID: 6273640
display name: JMJD1C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference3107
data source: Provenance1
name: Histone H3.3 with methylated lysine9 (H3K9)
name: OS04T0450800-01
xref: UnificationXref23739
feature: FragmentFeature7659
feature: ModificationFeature731
cellular location: GO_0005654
comment: Reactome DB_ID: 6273631
display name: MeK-H3F3A

UniProt:Q69J40
type: ProteinReference
xref: UnificationXref9154
organism: http://identifiers.org/taxonomy/4530

Homologues of JMJD1C
type: Protein
data source: Provenance1
member physical entity: JHD2C_HUMAN
xref: UnificationXref23761
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273659

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference3105
data source: Provenance1
name: Histone H3.3 with methylated lysine9 (H3K9)
name: OS04T0450800-02
xref: UnificationXref23737
feature: FragmentFeature7657
feature: ModificationFeature729
cellular location: GO_0005654
comment: Reactome DB_ID: 6273627
display name: MeK-H3F3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2RAD9
data source: Provenance1
name: Histone H3.3 with methylated lysine9 (H3K9)
name: MeK-H3F3A
xref: UnificationXref23738
feature: FragmentFeature7658
feature: ModificationFeature730
cellular location: GO_0005654
comment: Reactome DB_ID: 6273629
display name: Q2RAD9

Homologues of MeK-H3F3A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23740
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273632

http://identifiers.org/pubmed/3391615
type: PublicationXref
id: 3391615
author: Robertson, D A
author: Baker, E G
author: Morris, C P
author: Hopwood, J J
author: Callen, D F
db: Pubmed
title: Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
source: Hum. Genet. 79:175-8
year: 1988

UnificationXref22189
type: UnificationXref
id: Q10I26
db: UniProt

UnificationXref10577
type: UnificationXref
id: 6276025
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276025

UnificationXref10578
type: UnificationXref
id: REACT_258550
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258550.1

UnificationXref10579
type: UnificationXref
id: 6275913
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275913

UnificationXref10573
type: UnificationXref
id: 6275906
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275906

Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1009
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11027
xref: UnificationXref11028
participant stoichiometry: Stoichiometry1223
participant stoichiometry: Stoichiometry1222
participant stoichiometry: Stoichiometry1224
left: SmallMolecule739
left: SmallMolecule761
left: SmallMolecule738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule762
right: SmallMolecule741
right: SmallMolecule492

UnificationXref10574
type: UnificationXref
id: 6275908
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275908

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1008
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11024
xref: UnificationXref11023
participant stoichiometry: Stoichiometry1220
participant stoichiometry: Stoichiometry1221
left: SmallMolecule760
left: SmallMolecule742
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule744
right: SmallMolecule746
right: SmallMolecule733
right: SmallMolecule761
right: SmallMolecule492

UnificationXref10575
type: UnificationXref
id: 6275909
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275909

Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1011
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11037
xref: UnificationXref11038
participant stoichiometry: Stoichiometry1226
left: SmallMolecule763
left: SmallMolecule742
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule744
right: SmallMolecule733
right: SmallMolecule764
right: SmallMolecule492

UnificationXref10576
type: UnificationXref
id: 6275911
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275911

arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1010
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11033
xref: UnificationXref11032
participant stoichiometry: Stoichiometry1225
left: SmallMolecule762
left: SmallMolecule742
left: SmallMolecule743
display name: Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule763
right: SmallMolecule744
right: SmallMolecule733
right: SmallMolecule492

Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
type: Pathway
data source: Provenance1
pathway component: REACT 235314.1
evidence: Evidence681
xref: UnificationXref8059
xref: UnificationXref8058
pathway order: PathwayStep664
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref22180
type: UnificationXref
id: 6269642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269642

UnificationXref22182
type: UnificationXref
id: REACT_240282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240282.1

UnificationXref10570
type: UnificationXref
id: B9G9Y3
db: UniProt

Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1012
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.19.3
xref: UnificationXref11043
xref: UnificationXref11042
participant stoichiometry: Stoichiometry1227
participant stoichiometry: Stoichiometry1229
participant stoichiometry: Stoichiometry1228
left: SmallMolecule764
left: SmallMolecule739
left: SmallMolecule738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule765
right: SmallMolecule741
right: SmallMolecule492

UnificationXref22181
type: UnificationXref
id: 6269644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269644

Translocation of tetracosapentaenoyl-CoA to peroxisomes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1013
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11048
xref: UnificationXref11049
left: SmallMolecule765
left: SmallMolecule734
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule752
right: SmallMolecule767
right: SmallMolecule766

UnificationXref22184
type: UnificationXref
id: REACT_210067
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210067.2

UnificationXref10572
type: UnificationXref
id: 6276024
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276024

Prostaglandin E synthase isomerizes PGH2 to PGE2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1016
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.99.3
xref: UnificationXref11071
xref: UnificationXref11072
left: SmallMolecule768
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule769

UnificationXref22183
type: UnificationXref
id: 6279899
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279899

UnificationXref10571
type: UnificationXref
id: 6276023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276023

PGE2 is converted to PGF2a by CBR1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1017
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.189
xref: UnificationXref11116
xref: UnificationXref11115
left: proton
left: NADPH
left: SmallMolecule769
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule770
right: NADP+

UnificationXref22186
type: UnificationXref
id: REACT_207547
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207547.2

PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1018
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.141
xref: UnificationXref11206
xref: UnificationXref11205
left: SmallMolecule771
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule773

UnificationXref22185
type: UnificationXref
id: 6279900
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279900

15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1019
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11243
xref: UnificationXref11242
left: proton
left: NADPH
left: SmallMolecule777
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule778

UnificationXref22188
type: UnificationXref
id: 6272760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272760

UnificationXref22187
type: UnificationXref
id: Q5VNM3
db: UniProt

UnificationXref10568
type: UnificationXref
id: Q2R903
db: UniProt

Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1020
conversion direction: LEFT_TO_RIGHT
EC number: 5.3.99.5
xref: UnificationXref11341
xref: UnificationXref11340
left: SmallMolecule781
display name: PGH2 is isomerised to TXA2 by TBXAS1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule782

UnificationXref10569
type: UnificationXref
id: 6276022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276022

UnificationXref10566
type: UnificationXref
id: REACT_123497
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123497.1

UnificationXref10567
type: UnificationXref
id: 6275910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275910

UnificationXref10564
type: UnificationXref
id: REACT_219706
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219706.2

CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1025
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.13.30
xref: UnificationXref11375
xref: UnificationXref11376
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule786
display name: LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule788

UnificationXref10565
type: UnificationXref
id: 1806221
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806221

LTB4 is oxidised to 12-oxoLTB4 by PTGR1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1024
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11367
xref: UnificationXref11366
left: NADP+
left: SmallMolecule786
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: SmallMolecule787
right: NADPH

UnificationXref10562
type: UnificationXref
id: REACT_122405
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122405.1

LTA4 is hydolysed to LTB4 by LTA4H
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1023
conversion direction: LEFT_TO_RIGHT
EC number: 3.3.2.6
xref: UnificationXref11362
xref: UnificationXref11361
left: SmallMolecule785
left: Water
display name: LTA4 is hydrolyzed to LTB4
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule786

UnificationXref10563
type: UnificationXref
id: 6276065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276065

PGH2 is degraded to 12S-HHT and MDA by TBXAS1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1021
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11349
xref: UnificationXref11348
left: SmallMolecule781
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule783
right: SmallMolecule784

UnificationXref22191
type: UnificationXref
id: 6272764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272764

UnificationXref22190
type: UnificationXref
id: 6272763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6272763

UnificationXref22195
type: UnificationXref
id: 6259659
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259659

UnificationXref10561
type: UnificationXref
id: 1806217
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806217

LTC4 is exported from the cytosol by ABCC1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1028
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11392
xref: UnificationXref11393
left: SmallMolecule791
display name: ABCC1 mediates LTC4 export from the cell
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule792

UnificationXref22194
type: UnificationXref
id: 6259658
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259658

UnificationXref10560
type: UnificationXref
id: REACT_217563
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_217563.2

Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1029
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.2.2
xref: UnificationXref11426
xref: UnificationXref11427
left: SmallMolecule792
display name: LTC4 is converted to LTD4 by GGT1/5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule793
right: SmallMolecule794

UnificationXref22193
type: UnificationXref
id: 6259657
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259657

20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1026
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11381
xref: UnificationXref11380
participant stoichiometry: Stoichiometry1233
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule788
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule789

UnificationXref22192
type: UnificationXref
id: 6259656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259656

20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1027
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11386
xref: UnificationXref11385
left: proton
left: SmallMolecule293
left: NADPH
left: SmallMolecule789
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: NADP+
right: SmallMolecule790

UnificationXref22199
type: UnificationXref
id: 6259654
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259654

UnificationXref22198
type: UnificationXref
id: 6259653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259653

UnificationXref22197
type: UnificationXref
id: 6259652
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259652

LTA4 is converted to EXA4 by ALOX15
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1030
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11438
xref: UnificationXref11437
left: SmallMolecule785
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule795

UnificationXref22196
type: UnificationXref
id: 6259651
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259651

UnificationXref10551
type: UnificationXref
id: 6276007
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276007

UnificationXref10552
type: UnificationXref
id: Q69SU0
db: UniProt

UnificationXref10553
type: UnificationXref
id: 6276008
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276008

PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence985
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10896
xref: UnificationXref10895
left: SmallMolecule729
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule730

UnificationXref10554
type: UnificationXref
id: Q0IT47
db: UniProt

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence984
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10887
xref: UnificationXref10888
left: SmallMolecule729
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule728
right: SmallMolecule3

UnificationXref22167
type: UnificationXref
id: 429875
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429875

UnificationXref10555
type: UnificationXref
id: 6276009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276009

UnificationXref22168
type: UnificationXref
id: REACT_20726
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20726.1

UnificationXref10556
type: UnificationXref
id: 6276010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276010

UnificationXref22169
type: UnificationXref
id: 6269628
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269628

UnificationXref10557
type: UnificationXref
id: 6276012
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276012

UnificationXref10558
type: UnificationXref
id: REACT_226724
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226724.2

UnificationXref10559
type: UnificationXref
id: 6280037
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280037

UnificationXref22164
type: UnificationXref
id: 6269645
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269645

Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence993
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.19.3
xref: UnificationXref10939
xref: UnificationXref10938
participant stoichiometry: Stoichiometry1204
participant stoichiometry: Stoichiometry1203
participant stoichiometry: Stoichiometry1202
left: SmallMolecule736
left: SmallMolecule739
left: SmallMolecule738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule740
right: SmallMolecule741
right: SmallMolecule492

UnificationXref22163
type: UnificationXref
id: 6269627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269627

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence994
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10952
xref: UnificationXref10951
participant stoichiometry: Stoichiometry1205
participant stoichiometry: Stoichiometry1206
left: SmallMolecule740
left: SmallMolecule742
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule744
right: SmallMolecule745
right: SmallMolecule746
right: SmallMolecule733
right: SmallMolecule492

UnificationXref22166
type: UnificationXref
id: REACT_208358
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_208358.2

Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence995
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10957
xref: UnificationXref10956
participant stoichiometry: Stoichiometry1209
participant stoichiometry: Stoichiometry1208
participant stoichiometry: Stoichiometry1207
left: SmallMolecule745
left: SmallMolecule739
left: SmallMolecule738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule747
right: SmallMolecule741
right: SmallMolecule492

UnificationXref22165
type: UnificationXref
id: 6269646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269646

Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence996
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10963
xref: UnificationXref10962
participant stoichiometry: Stoichiometry1210
participant stoichiometry: Stoichiometry1211
left: SmallMolecule747
left: SmallMolecule742
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule744
right: SmallMolecule746
right: SmallMolecule733
right: SmallMolecule748
right: SmallMolecule492

UnificationXref22160
type: UnificationXref
id: Q0JCW8
db: UniProt

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence986
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10900
xref: UnificationXref10899
left: SmallMolecule5
left: SmallMolecule731
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule730

PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence987
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.137
xref: UnificationXref10901
xref: UnificationXref10902
left: SmallMolecule5
left: SmallMolecule731
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule728
right: SmallMolecule6

UnificationXref22162
type: UnificationXref
id: 6269602
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269602

UnificationXref10550
type: UnificationXref
id: B9F7S0
db: UniProt

PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence988
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.64
xref: UnificationXref10903
xref: UnificationXref10904
left: SmallMolecule728
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule731

UnificationXref22161
type: UnificationXref
id: 6269601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269601

Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence992
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref10926
xref: UnificationXref10927
left: SmallMolecule733
left: SmallMolecule734
left: SmallMolecule732
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule735
right: SmallMolecule736
right: SmallMolecule737

UnificationXref10542
type: UnificationXref
id: 6275811
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275811

Translocation of tetracosahexaenoyl-CoA to peroxisomes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence999
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10979
xref: UnificationXref10978
left: SmallMolecule734
left: SmallMolecule750
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule678
right: SmallMolecule752
right: SmallMolecule751

UnificationXref10543
type: UnificationXref
id: Q53RI7
db: UniProt

Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence998
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.19.3
xref: UnificationXref10973
xref: UnificationXref10972
participant stoichiometry: Stoichiometry1216
participant stoichiometry: Stoichiometry1215
participant stoichiometry: Stoichiometry1214
left: SmallMolecule739
left: SmallMolecule749
left: SmallMolecule738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule750
right: SmallMolecule741
right: SmallMolecule492

UnificationXref10540
type: UnificationXref
id: 6275809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275809

Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence997
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10967
xref: UnificationXref10968
participant stoichiometry: Stoichiometry1213
participant stoichiometry: Stoichiometry1212
left: SmallMolecule748
left: SmallMolecule742
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule744
right: SmallMolecule746
right: SmallMolecule733
right: SmallMolecule749
right: SmallMolecule492

UnificationXref10541
type: UnificationXref
id: Q10E17
db: UniProt

UnificationXref10546
type: UnificationXref
id: 6275816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275816

UnificationXref10547
type: UnificationXref
id: REACT_223844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223844.2

UnificationXref22178
type: UnificationXref
id: B9F009
db: UniProt

UnificationXref10544
type: UnificationXref
id: 6275813
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275813

UnificationXref22179
type: UnificationXref
id: 6269641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269641

UnificationXref10545
type: UnificationXref
id: 6275814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275814

UnificationXref10548
type: UnificationXref
id: Q0DSS8
db: UniProt

UnificationXref10549
type: UnificationXref
id: 6276006
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6276006

UnificationXref22177
type: UnificationXref
id: 6269639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269639

Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1007
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.19.3
xref: UnificationXref11018
xref: UnificationXref11019
participant stoichiometry: Stoichiometry1219
participant stoichiometry: Stoichiometry1218
participant stoichiometry: Stoichiometry1217
left: SmallMolecule739
left: SmallMolecule738
left: SmallMolecule759
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule760
right: SmallMolecule741
right: SmallMolecule492

Iron uptake and transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction212
pathway component: BiochemicalReaction246
pathway component: BiochemicalReaction245
pathway component: BiochemicalReaction244
evidence: Evidence408
xref: UnificationXref5461
xref: UnificationXref5460
xref: RelationshipXref258
pathway order: PathwayStep397
pathway order: PathwayStep349
pathway order: PathwayStep396
pathway order: PathwayStep395
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

UnificationXref22176
type: UnificationXref
id: Q5N739
db: UniProt

UnificationXref22175
type: UnificationXref
id: 6269637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269637

Conversion of DHA-CoA to docosahexaenoic acid (DHA)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1004
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.2.1
xref: UnificationXref11004
xref: UnificationXref11003
left: SmallMolecule570
left: SmallMolecule756
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule578
right: SmallMolecule757

UnificationXref22174
type: UnificationXref
id: Q8RV84
db: UniProt

Activation of linoleic acid to linoleoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1006
conversion direction: LEFT_TO_RIGHT
EC number: 6.2.1.3
xref: UnificationXref11014
xref: UnificationXref11013
left: SmallMolecule733
left: SmallMolecule734
left: SmallMolecule758
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule735
right: SmallMolecule737
right: SmallMolecule759

UnificationXref22173
type: UnificationXref
id: 6269634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269634

Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1002
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.74
xref: UnificationXref10993
xref: UnificationXref10994
left: SmallMolecule754
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule755

UnificationXref22172
type: UnificationXref
id: Q0D7K3
db: UniProt

Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1003
conversion direction: LEFT_TO_RIGHT
EC number: 2.8.3.8
xref: UnificationXref10999
xref: UnificationXref10998
left: SmallMolecule578
left: SmallMolecule755
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule576
right: SmallMolecule756

UnificationXref22171
type: UnificationXref
id: 6269631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269631

Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1000
conversion direction: LEFT_TO_RIGHT
EC number: 1.3.3.6
xref: UnificationXref10983
xref: UnificationXref10984
left: SmallMolecule751
left: SmallMolecule566
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule753
right: SmallMolecule568

UnificationXref22170
type: UnificationXref
id: Q6K2K4
db: UniProt

Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1001
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.74
xref: UnificationXref10988
xref: UnificationXref10989
left: SmallMolecule753
left: SmallMolecule570
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule754

UnificationXref14690
type: UnificationXref
id: REACT_238857
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238857.1

UnificationXref14691
type: UnificationXref
id: CHEBI:30805
db: ChEBI

UnificationXref14692
type: UnificationXref
id: 33549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=33549

UnificationXref14693
type: UnificationXref
id: REACT_5268
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5268.2

UnificationXref14694
type: UnificationXref
id: CHEBI:39567
db: ChEBI

UnificationXref10538
type: UnificationXref
id: REACT_123454
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123454.1

UnificationXref14695
type: UnificationXref
id: 42373
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=42373

UnificationXref10537
type: UnificationXref
id: 1806234
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806234

UnificationXref14696
type: UnificationXref
id: REACT_4949
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4949.1

UnificationXref14697
type: UnificationXref
id: 6259941
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259941

UnificationXref10539
type: UnificationXref
id: B9FB57
db: UniProt

UnificationXref10534
type: UnificationXref
id: 6279510
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279510

UnificationXref10533
type: UnificationXref
id: REACT_227259
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227259.2

UnificationXref10536
type: UnificationXref
id: CHEBI:17526
db: ChEBI

UnificationXref10535
type: UnificationXref
id: REACT_175946
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_175946.3

UnificationXref10530
type: UnificationXref
id: 6275105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275105

UnificationXref10532
type: UnificationXref
id: 6280013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6280013

UnificationXref10531
type: UnificationXref
id: REACT_186262
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186262.3

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence962
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10678
xref: UnificationXref10679
left: SmallMolecule715
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule714

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence961
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.150
xref: UnificationXref10676
xref: UnificationXref10677
left: SmallMolecule714
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule715
right: SmallMolecule6

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence964
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.36
xref: UnificationXref10696
xref: UnificationXref10697
left: SmallMolecule717
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule712

PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence963
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10687
xref: UnificationXref10686
left: SmallMolecule716
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule712

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence967
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.36
xref: UnificationXref10734
xref: UnificationXref10733
left: Water
left: SmallMolecule314
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule718
right: SmallMolecule3

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence966
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.68
xref: UnificationXref10729
xref: UnificationXref10728
left: SmallMolecule718
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule314
right: SmallMolecule6

PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence969
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10740
xref: UnificationXref10741
left: Water
left: SmallMolecule317
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule719

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence968
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10738
xref: UnificationXref10737
left: SmallMolecule5
left: SmallMolecule719
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule317

UnificationXref14699
type: UnificationXref
id: REACT_238261
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238261.1

PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence971
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.64
xref: UnificationXref10771
xref: UnificationXref10772
left: Water
left: SmallMolecule720
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule721

UnificationXref14698
type: UnificationXref
id: 6259943
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6259943

PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence970
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10752
xref: UnificationXref10753
left: SmallMolecule5
left: SmallMolecule720
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule719

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

UnificationXref14681
type: UnificationXref
id: 6266393
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266393

UnificationXref14682
type: UnificationXref
id: 6266394
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266394

UnificationXref14680
type: UnificationXref
id: 6266392
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266392

UnificationXref14685
type: UnificationXref
id: 6266397
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266397

UnificationXref10529
type: UnificationXref
id: REACT_124886
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124886.1

UnificationXref14686
type: UnificationXref
id: 6266398
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266398

UnificationXref10528
type: UnificationXref
id: 1524080
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524080

UnificationXref14683
type: UnificationXref
id: 6266395
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266395

UnificationXref10527
type: UnificationXref
id: CHEBI:60431
db: ChEBI

UnificationXref14684
type: UnificationXref
id: 6266396
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266396

UnificationXref10526
type: UnificationXref
id: REACT_186263
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186263.3

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

UnificationXref10525
type: UnificationXref
id: 6275104
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275104

UnificationXref10524
type: UnificationXref
id: REACT_124296
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124296.1

UnificationXref10523
type: UnificationXref
id: 1524081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524081

UnificationXref10522
type: UnificationXref
id: REACT_125093
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125093.1

http://identifiers.org/pubmed/7913309
type: PublicationXref
id: 7913309
author: Rokosz, LL
author: Cueto, MA
author: Butkiewicz, EA
author: Hermes, JD
author: Boulton, DA
author: Sanyal, G
author: Lachance, PA
db: Pubmed
title: Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
source: Arch Biochem Biophys 312:1-13
year: 1994

UnificationXref10521
type: UnificationXref
id: 1524069
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524069

UnificationXref10520
type: UnificationXref
id: REACT_186270
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186270.3

PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence972
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10777
xref: UnificationXref10778
left: SmallMolecule5
left: SmallMolecule721
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule722
right: SmallMolecule6

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence977
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.150
xref: UnificationXref10826
xref: UnificationXref10827
left: SmallMolecule724
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule725
right: SmallMolecule6

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence975
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.149
xref: UnificationXref10787
xref: UnificationXref10786
left: SmallMolecule722
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule314
right: SmallMolecule6

PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence974
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10784
xref: UnificationXref10783
left: Water
left: SmallMolecule723
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule722

PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence973
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.150
xref: UnificationXref10782
xref: UnificationXref10781
left: SmallMolecule5
left: SmallMolecule720
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule723
right: SmallMolecule6

PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence981
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.64
xref: UnificationXref10846
xref: UnificationXref10845
left: Water
left: SmallMolecule724
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule727
right: SmallMolecule3

PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence980
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.137
xref: UnificationXref10844
xref: UnificationXref10843
left: SmallMolecule727
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule724
right: SmallMolecule6

PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence979
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10839
xref: UnificationXref10840
left: Water
left: SmallMolecule725
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule726
right: SmallMolecule3

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence978
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10828
xref: UnificationXref10829
left: Water
left: SmallMolecule725
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule724

http://identifiers.org/pubmed/8033208
type: PublicationXref
id: 8033208
author: Shirodkar, S
author: Kaelin WG, Jr
author: Livingston, DM
author: Ewen, ME
author: Krek, W
author: Arany, Z
db: Pubmed
title: Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
source: Cell 78:161-72
year: 1994

UnificationXref14689
type: UnificationXref
id: 6279819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279819

UnificationXref14688
type: UnificationXref
id: REACT_256955
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256955.1

UnificationXref14687
type: UnificationXref
id: 6266400
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266400

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence983
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.150
xref: UnificationXref10885
xref: UnificationXref10886
left: SmallMolecule728
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule729
right: SmallMolecule6

UnificationXref14672
type: UnificationXref
id: 6266384
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266384

UnificationXref10516
type: UnificationXref
id: REACT_125543
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125543.1

UnificationXref14673
type: UnificationXref
id: 6266385
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266385

UnificationXref10515
type: UnificationXref
id: 1524089
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524089

UnificationXref14674
type: UnificationXref
id: 6266386
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266386

UnificationXref10518
type: UnificationXref
id: REACT_186251
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186251.3

UnificationXref14675
type: UnificationXref
id: 6266387
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266387

UnificationXref10517
type: UnificationXref
id: 6275099
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275099

UniProt:B7FA07
type: ProteinReference
xref: UnificationXref6958
organism: http://identifiers.org/taxonomy/4530

UnificationXref10519
type: UnificationXref
id: 6275111
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275111

UnificationXref14670
type: UnificationXref
id: 6266382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266382

UnificationXref14671
type: UnificationXref
id: 6266383
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266383

UnificationXref10510
type: UnificationXref
id: 6275092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275092

UnificationXref10512
type: UnificationXref
id: REACT_186250
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186250.3

UnificationXref10511
type: UnificationXref
id: 6275094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275094

UnificationXref10514
type: UnificationXref
id: REACT_186255
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186255.3

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

UnificationXref10513
type: UnificationXref
id: 6275096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275096

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

UnificationXref14677
type: UnificationXref
id: 6266389
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266389

UnificationXref14676
type: UnificationXref
id: 6266388
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266388

UnificationXref14679
type: UnificationXref
id: 6266391
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266391

UnificationXref14678
type: UnificationXref
id: 6266390
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266390

UnificationXref14663
type: UnificationXref
id: 6266375
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266375

UnificationXref10507
type: UnificationXref
id: 6275089
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275089

UnificationXref14664
type: UnificationXref
id: 6266376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266376

UnificationXref10506
type: UnificationXref
id: Q7XPI9
db: UniProt

UnificationXref14661
type: UnificationXref
id: 6266373
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266373

UnificationXref10505
type: UnificationXref
id: REACT_123292
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123292.1

UnificationXref14662
type: UnificationXref
id: 6266374
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266374

UnificationXref10504
type: UnificationXref
id: 1524079
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524079

UnificationXref14660
type: UnificationXref
id: 6266372
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266372

UnificationXref10509
type: UnificationXref
id: 6275091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275091

UnificationXref10508
type: UnificationXref
id: Q0J990
db: UniProt

http://identifiers.org/pubmed/9852097
type: PublicationXref
id: 9852097
author: Kerr, TA
author: Russell, DW
author: Li, WP
author: Sakai, J
author: Lund, EG
db: Pubmed
title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
source: J Biol Chem 273:34316-27
year: 1998

UnificationXref10503
type: UnificationXref
id: REACT_123796
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123796.1

UnificationXref10502
type: UnificationXref
id: 1524075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524075

UnificationXref10501
type: UnificationXref
id: REACT_186240
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_186240.3

UnificationXref10500
type: UnificationXref
id: 6275086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6275086

PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence957
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.67
xref: UnificationXref10579
xref: UnificationXref10580
left: SmallMolecule679
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule712
right: SmallMolecule6

PI4KB binds to ARF1/3:GTP at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence956
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10577
xref: UnificationXref10578
left: Complex505
left: Protein4221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex506

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence955
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.67
xref: UnificationXref10564
xref: UnificationXref10563
left: SmallMolecule679
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule712
right: SmallMolecule6

PI4P is dephosphorylated to PI by SACM1L at the ER membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence953
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10557
xref: UnificationXref10558
left: Water
left: SmallMolecule711
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule678
right: SmallMolecule3

http://identifiers.org/pubmed/12176987
type: PublicationXref
id: 12176987
author: Tanabe, K
author: Tanaka, AR
author: Ueda, K
author: Morita, M
author: Kurisu, M
author: Matsuo, M
author: Kasiwayama, Y
author: Kioka, N
author: Imanaka, T
author: Amachi, T
db: Pubmed
title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
source: J Biol Chem 277:40142-7
year: 2002

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence952
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.67
xref: UnificationXref10546
xref: UnificationXref10547
left: SmallMolecule678
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule711
right: SmallMolecule6

DLCL is acylated to MLCL by LCLAT1 (ER)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence949
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10530
xref: UnificationXref10531
left: SmallMolecule528
left: SmallMolecule710
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule708
right: coenzyme A

MLCL is acylated to CL by LCLAT1 (ER)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence948
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10526
xref: UnificationXref10525
left: SmallMolecule708
left: SmallMolecule528
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule709
right: coenzyme A

UnificationXref14669
type: UnificationXref
id: 6266381
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266381

UnificationXref14668
type: UnificationXref
id: 6266380
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266380

UnificationXref14667
type: UnificationXref
id: 6266379
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266379

PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence960
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.64
xref: UnificationXref10610
xref: UnificationXref10611
left: Water
left: SmallMolecule714
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule679
right: SmallMolecule3

UnificationXref14666
type: UnificationXref
id: 6266378
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266378

PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence959
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.137
xref: UnificationXref10608
xref: UnificationXref10609
left: SmallMolecule679
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule714
right: SmallMolecule6

UnificationXref14665
type: UnificationXref
id: 6266377
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266377

PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence958
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref10587
xref: UnificationXref10586
left: SmallMolecule712
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule679
right: SmallMolecule3

UnificationXref14656
type: UnificationXref
id: 6266368
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266368

UnificationXref14657
type: UnificationXref
id: 6266369
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266369

UnificationXref14654
type: UnificationXref
id: 6266366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266366

UnificationXref14655
type: UnificationXref
id: 6266367
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266367

UnificationXref14658
type: UnificationXref
id: 6266370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266370

UnificationXref14659
type: UnificationXref
id: 6266371
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266371

UnificationXref22100
type: UnificationXref
id: 6269699
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269699

http://identifiers.org/pubmed/7816143
type: PublicationXref
id: 7816143
author: Glover, JN
author: Harrison, SC
db: Pubmed
title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
source: Nature 373:257-61
year: 1995

UnificationXref22103
type: UnificationXref
id: 6269672
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269672

UnificationXref22104
type: UnificationXref
id: B9G2C8
db: UniProt

UnificationXref22101
type: UnificationXref
id: 6269700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269700

UnificationXref22102
type: UnificationXref
id: Q84T68
db: UniProt

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

UnificationXref22107
type: UnificationXref
id: 6269662
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269662

UnificationXref22108
type: UnificationXref
id: Q53M91
db: UniProt

UnificationXref22105
type: UnificationXref
id: 6269656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269656

UnificationXref22106
type: UnificationXref
id: Q0IT44
db: UniProt

UnificationXref22109
type: UnificationXref
id: 6269664
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269664

UnificationXref14653
type: UnificationXref
id: 6266365
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266365

UnificationXref14652
type: UnificationXref
id: 6266364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266364

UnificationXref14651
type: UnificationXref
id: 6266363
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266363

UnificationXref14650
type: UnificationXref
id: 6266362
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266362

UnificationXref14643
type: UnificationXref
id: 6266355
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266355

UnificationXref14644
type: UnificationXref
id: 6266356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266356

UnificationXref14645
type: UnificationXref
id: 6266357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266357

UnificationXref14646
type: UnificationXref
id: 6266358
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266358

UnificationXref14647
type: UnificationXref
id: 6266359
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266359

UnificationXref14648
type: UnificationXref
id: 6266360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266360

UnificationXref14649
type: UnificationXref
id: 6266361
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266361

UnificationXref22111
type: UnificationXref
id: 6269666
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269666

UnificationXref22110
type: UnificationXref
id: Q53M89
db: UniProt

UnificationXref22112
type: UnificationXref
id: B7ELW5
db: UniProt

UnificationXref22113
type: UnificationXref
id: 6269668
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269668

UnificationXref22114
type: UnificationXref
id: 6269669
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269669

UnificationXref22115
type: UnificationXref
id: Q2QT85
db: UniProt

UnificationXref22116
type: UnificationXref
id: 6269659
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269659

UnificationXref22117
type: UnificationXref
id: Q69UI6
db: UniProt

UnificationXref22118
type: UnificationXref
id: 6269649
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269649

http://identifiers.org/pubmed/20154325
type: PublicationXref
id: 20154325
author: Beese, Lorena S
author: Tsai, Miaw-Sheue
author: Genschel, Jochen
author: Modrich, Paul
author: Iyer, Ravi R
author: Pluciennik, Anna
db: Pubmed
title: MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta
source: J. Biol. Chem. 285:11730-9
year: 2010

UnificationXref22119
type: UnificationXref
id: Q75LC8
db: UniProt

UnificationXref14640
type: UnificationXref
id: 6266352
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266352

UnificationXref14642
type: UnificationXref
id: 6266354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266354

UnificationXref14641
type: UnificationXref
id: 6266353
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266353

UnificationXref14638
type: UnificationXref
id: 213144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213144

UnificationXref14639
type: UnificationXref
id: REACT_14369
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14369.2

http://identifiers.org/pubmed/12176931
type: PublicationXref
id: 12176931
author: Lamond, AI
author: Ryder, U
author: Rappsilber, J
author: Mann, M
db: Pubmed
title: Large-scale proteomic analysis of the human spliceosome.
source: Genome Res 12:1231-45
year: 2002

UnificationXref14636
type: UnificationXref
id: REACT_4713
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4713.3

UnificationXref14637
type: UnificationXref
id: CHEBI:34477
db: ChEBI

UnificationXref14634
type: UnificationXref
id: REACT_263420
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263420.1

UnificationXref14635
type: UnificationXref
id: 30321
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30321

UnificationXref14632
type: UnificationXref
id: 6266841
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266841

UnificationXref14633
type: UnificationXref
id: 6266843
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6266843

UniProt:P49100
type: ProteinReference
xref: UnificationXref7522
organism: http://identifiers.org/taxonomy/4530

UnificationXref14631
type: UnificationXref
id: 6261512
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261512

UnificationXref14630
type: UnificationXref
id: 6261511
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261511

UnificationXref14625
type: UnificationXref
id: 6261506
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261506

UnificationXref14626
type: UnificationXref
id: 6261507
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261507

UnificationXref14627
type: UnificationXref
id: 6261508
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261508

UnificationXref14628
type: UnificationXref
id: 6261509
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261509

UnificationXref14621
type: UnificationXref
id: 6261502
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261502

UnificationXref14622
type: UnificationXref
id: 6261503
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261503

UnificationXref14623
type: UnificationXref
id: 6261504
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261504

UnificationXref14624
type: UnificationXref
id: 6261505
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261505

http://identifiers.org/pubmed/11274057
type: PublicationXref
id: 11274057
author: Jiricny, J
author: Kleczkowska, H E
author: Lettieri, T
author: Marra, G
db: Pubmed
title: hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
source: Genes Dev. 15:724-36
year: 2001

UnificationXref14629
type: UnificationXref
id: 6261510
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261510

http://identifiers.org/pubmed/12496762
type: PublicationXref
id: 12496762
author: Yamaguchi, Yu
author: Nguyen, Louis N
author: Murai, Keith K
author: Pasquale, Elena B
author: Irie, Fumitoshi
db: Pubmed
title: Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
source: Nat. Neurosci. 6:153-60
year: 2003

UnificationXref14620
type: UnificationXref
id: 6261501
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261501

http://identifiers.org/pubmed/12807903
type: PublicationXref
id: 12807903
author: Nagai, M
author: Sudol, M
author: Navin, NE
author: Komuro, A
db: Pubmed
title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
source: J Biol Chem 278:33334-41
year: 2003

UnificationXref22140
type: UnificationXref
id: Q9LGE6
db: UniProt

UnificationXref14619
type: UnificationXref
id: 6261500
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261500

Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1070
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.22
xref: UnificationXref11799
xref: UnificationXref11800
left: SmallMolecule335
left: SmallMolecule846
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule342
right: SmallMolecule843

UnificationXref14618
type: UnificationXref
id: 6261499
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261499

Both hexosaminidase A and B can cleave GalNAc from globoside
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1069
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.52
xref: UnificationXref11794
xref: UnificationXref11795
left: SmallMolecule335
left: SmallMolecule845
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule345
right: SmallMolecule846

UnificationXref22143
type: UnificationXref
id: 6269614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269614

Stoichiometry1702
type: Stoichiometry
physical entity: Protein5896
stoichiometric coefficient: 1.0

UnificationXref22144
type: UnificationXref
id: Q6K2E9
db: UniProt

Stoichiometry1701
type: Stoichiometry
physical entity: PhysicalEntity184
stoichiometric coefficient: 1.0

UnificationXref22141
type: UnificationXref
id: 6269608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269608

Stoichiometry1700
type: Stoichiometry
physical entity: Protein5896
stoichiometric coefficient: 1.0

UnificationXref22142
type: UnificationXref
id: Q0JDN9
db: UniProt

Stoichiometry1706
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 2.0

UnificationXref14613
type: UnificationXref
id: 6261494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261494

Stoichiometry1705
type: Stoichiometry
physical entity: Protein952
stoichiometric coefficient: 2.0

UnificationXref14612
type: UnificationXref
id: 6261493
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261493

Stoichiometry1704
type: Stoichiometry
physical entity: Protein5900
stoichiometric coefficient: 2.0

UnificationXref14611
type: UnificationXref
id: 6261492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261492

Stoichiometry1703
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 2.0

UnificationXref14610
type: UnificationXref
id: 6261491
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261491

UnificationXref14617
type: UnificationXref
id: 6261498
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261498

Stoichiometry1709
type: Stoichiometry
physical entity: Protein5910
stoichiometric coefficient: 1.0

UnificationXref14616
type: UnificationXref
id: 6261497
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261497

Stoichiometry1708
type: Stoichiometry
physical entity: Protein5907
stoichiometric coefficient: 1.0

UnificationXref14615
type: UnificationXref
id: 6261496
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261496

Stoichiometry1707
type: Stoichiometry
physical entity: Protein952
stoichiometric coefficient: 2.0

UnificationXref14614
type: UnificationXref
id: 6261495
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261495

UnificationXref22148
type: UnificationXref
id: 6269620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269620

sphinganine 1-phosphate => phosphoethanolamine + hexadecanal
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1062
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.2.27
xref: UnificationXref11751
xref: UnificationXref11752
left: SmallMolecule834
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule658
right: SmallMolecule836

UnificationXref22147
type: UnificationXref
id: 6269619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269619

sphingosine +ATP => sphingosine 1-phosphate + ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1063
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11760
xref: UnificationXref11759
left: SmallMolecule5
left: SmallMolecule837
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule838

UnificationXref22146
type: UnificationXref
id: Q0E0Z4
db: UniProt

sphinganine + stearyl-CoA => dihydroceramide + CoASH
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1060
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.24
xref: UnificationXref11736
xref: UnificationXref11737
left: SmallMolecule826
left: SmallMolecule526
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule828
right: coenzyme A

UnificationXref22145
type: UnificationXref
id: 6269617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269617

sphinganine 1-phosphate + H2O => sphinganine + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1061
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11745
xref: UnificationXref11744
left: Water
left: SmallMolecule834
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule835

Beta-galactosidase hydrolyses GM1 to GM2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1067
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.23
xref: UnificationXref11779
xref: UnificationXref11778
left: SmallMolecule841
left: SmallMolecule335
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule842
right: SmallMolecule342

Beta-galactosidase can also hydrolyse globosides to form cerebrosides
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1068
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.23
xref: UnificationXref11786
xref: UnificationXref11787
left: SmallMolecule335
left: SmallMolecule843
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule342
right: SmallMolecule844

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1064
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11764
xref: UnificationXref11763
left: Water
left: SmallMolecule838
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3
right: SmallMolecule839

UnificationXref22149
type: UnificationXref
id: Q60E54
db: UniProt

sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1065
conversion direction: LEFT_TO_RIGHT
EC number: 4.1.2.27
xref: UnificationXref11768
xref: UnificationXref11769
left: SmallMolecule838
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule840
right: SmallMolecule658

UnificationXref14608
type: UnificationXref
id: 6261489
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261489

UnificationXref14607
type: UnificationXref
id: 6261488
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261488

UnificationXref22150
type: UnificationXref
id: 6269611
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269611

UnificationXref22151
type: UnificationXref
id: 6269621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269621

UnificationXref14609
type: UnificationXref
id: 6261490
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261490

UnificationXref22152
type: UnificationXref
id: 6269622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269622

Stoichiometry1711
type: Stoichiometry
physical entity: Protein5917
stoichiometric coefficient: 1.0

UnificationXref22153
type: UnificationXref
id: 6269623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269623

Stoichiometry1710
type: Stoichiometry
physical entity: Protein5914
stoichiometric coefficient: 1.0

UnificationXref22154
type: UnificationXref
id: Q5N9F1
db: UniProt

Stoichiometry1713
type: Stoichiometry
physical entity: Protein5917
stoichiometric coefficient: 1.0

UnificationXref22155
type: UnificationXref
id: 6269605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269605

Stoichiometry1712
type: Stoichiometry
physical entity: PhysicalEntity185
stoichiometric coefficient: 1.0

Stoichiometry1715
type: Stoichiometry
physical entity: Protein5922
stoichiometric coefficient: 1.0

UnificationXref14600
type: UnificationXref
id: 6261481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261481

Stoichiometry1714
type: Stoichiometry
physical entity: Protein5921
stoichiometric coefficient: 1.0

Stoichiometry1717
type: Stoichiometry
physical entity: PhysicalEntity63
stoichiometric coefficient: 1.0

UnificationXref14602
type: UnificationXref
id: 6261483
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261483

Stoichiometry1716
type: Stoichiometry
physical entity: Complex777
stoichiometric coefficient: 1.0

UnificationXref14601
type: UnificationXref
id: 6261482
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261482

Stoichiometry1719
type: Stoichiometry
physical entity: Protein5931
stoichiometric coefficient: 1.0

UnificationXref14604
type: UnificationXref
id: 6261485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261485

Stoichiometry1718
type: Stoichiometry
physical entity: Protein5923
stoichiometric coefficient: 1.0

UnificationXref14603
type: UnificationXref
id: 6261484
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261484

UnificationXref14606
type: UnificationXref
id: 6261487
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261487

UnificationXref14605
type: UnificationXref
id: 6261486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6261486

UnificationXref22157
type: UnificationXref
id: 6269626
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269626

UnificationXref22156
type: UnificationXref
id: Q6ZBS1
db: UniProt

UnificationXref22159
type: UnificationXref
id: 6269599
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269599

UnificationXref22158
type: UnificationXref
id: Q7XUX0
db: UniProt

UnificationXref22121
type: UnificationXref
id: 6269653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269653

UnificationXref22122
type: UnificationXref
id: Q69T30
db: UniProt

Molybdopterin
type: SmallMoleculeReference
name: Molybdopterin [ChEBI:6969]
xref: UnificationXref7722

UnificationXref22120
type: UnificationXref
id: 6269652
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269652

15k-LXA4 is reduced to dhk-LXA4 by PTGR1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1044
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11559
xref: UnificationXref11560
left: proton
left: NADPH
left: SmallMolecule807
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule808

Sphingolipid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 220105.2
pathway component: REACT 225825.2
evidence: Evidence1076
xref: RelationshipXref940
xref: UnificationXref11860
xref: UnificationXref11859
pathway order: PathwayStep1053
pathway order: PathwayStep1062
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

LXA4 is oxidised to 15k-LXA4 by HPGD
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1043
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.141
xref: UnificationXref11554
xref: UnificationXref11555
left: SmallMolecule805
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: proton
right: SmallMolecule807

LTA4 is converted to LXA4/B4 by ALOX12
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1042
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11
xref: UnificationXref11549
xref: UnificationXref11550
left: SmallMolecule785
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule804

Arachidonic acid is converted to 12-oxoETE by ALOX12
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1040
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.31
xref: UnificationXref11538
xref: UnificationXref11539
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule803

Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1038
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.31
xref: UnificationXref11528
xref: UnificationXref11529
left: SmallMolecule293
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule801

Golgi membrane
type: CellularLocationVocabulary
xref: UnificationXref179

UnificationXref22129
type: UnificationXref
id: 6269682
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269682

12S-HpETE is reduced to 12S-HETE by GPX1/2/4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1039
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.9
xref: UnificationXref11534
xref: UnificationXref11533
participant stoichiometry: Stoichiometry1248
left: SmallMolecule801
left: SmallMolecule422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule802
right: SmallMolecule424

UnificationXref22128
type: UnificationXref
id: Q9SNK4
db: UniProt

Arachidonic acid is oxidised to 12R-HpETE by ALOX12B
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1036
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.31
xref: UnificationXref11511
xref: UnificationXref11512
left: SmallMolecule293
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule799

UnificationXref22127
type: UnificationXref
id: 6269679
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269679

12R-HpETE is reduced to 12R-HETE by GPX1/2/4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1037
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.9
xref: UnificationXref11516
xref: UnificationXref11517
participant stoichiometry: Stoichiometry1245
left: SmallMolecule799
left: SmallMolecule422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule800
right: SmallMolecule424

UnificationXref22126
type: UnificationXref
id: 6269678
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269678

5S-HpETE is reduced to 5S-HETE by GPX1/2/4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1032
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.9
xref: UnificationXref11466
xref: UnificationXref11465
participant stoichiometry: Stoichiometry1240
left: SmallMolecule796
left: SmallMolecule422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: SmallMolecule797
right: SmallMolecule424

UnificationXref22125
type: UnificationXref
id: 6269677
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269677

Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1034
conversion direction: LEFT_TO_RIGHT
EC number: 1.13.11.33
xref: UnificationXref11476
xref: UnificationXref11477
left: SmallMolecule293
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule798

UnificationXref22124
type: UnificationXref
id: B9F0H5
db: UniProt

UnificationXref22123
type: UnificationXref
id: 6269675
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269675

UnificationXref22130
type: UnificationXref
id: B9FAW7
db: UniProt

UnificationXref22131
type: UnificationXref
id: 6269684
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269684

UnificationXref22132
type: UnificationXref
id: Q8H885
db: UniProt

UnificationXref22133
type: UnificationXref
id: 6269686
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269686

phytoceramide + H2O => stearate + phytosphingosine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1058
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11714
xref: UnificationXref11713
left: SmallMolecule831
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule832
right: SmallMolecule833

palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1057
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.50
xref: UnificationXref11704
xref: UnificationXref11705
left: SmallMolecule116
left: SmallMolecule514
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule407
right: SmallMolecule825
right: coenzyme A

sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1059
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.91
xref: UnificationXref11727
xref: UnificationXref11728
left: SmallMolecule826
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule6
right: SmallMolecule834

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

UnificationXref22139
type: UnificationXref
id: REACT_213439
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213439.2

EET(1) is hydrolysed to DHET(1) by EPHX2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1051
conversion direction: LEFT_TO_RIGHT
EC number: 3.3.2.10
xref: UnificationXref11648
xref: UnificationXref11647
left: SmallMolecule815
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule820

UnificationXref22138
type: UnificationXref
id: 6279903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6279903

3-ketosphinganine + NADPH + H+ => sphinganine + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1054
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.102
xref: UnificationXref11661
xref: UnificationXref11662
left: proton
left: NADPH
left: SmallMolecule825
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule826

dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1055
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11673
xref: UnificationXref11674
left: proton
left: SmallMolecule828
left: SmallMolecule293
left: SmallMolecule827
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule830
right: Water
right: SmallMolecule829

dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1056
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11679
xref: UnificationXref11678
left: proton
left: SmallMolecule828
left: SmallMolecule293
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule831
right: Water
right: NADP+

UnificationXref22135
type: UnificationXref
id: 6269707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269707

UnificationXref22134
type: UnificationXref
id: 6269687
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269687

Arachidonic acid is converted to HXA3/B3 by ALOX12
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1046
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11571
xref: UnificationXref11570
left: SmallMolecule293
left: SmallMolecule515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule809

UnificationXref22137
type: UnificationXref
id: REACT_207034
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207034.2

Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1048
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11579
xref: UnificationXref11580
left: SmallMolecule812
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule813
right: SmallMolecule746
right: SmallMolecule492

UnificationXref22136
type: UnificationXref
id: 6269709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6269709

Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence1049
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref11585
xref: UnificationXref11586
left: SmallMolecule812
left: SmallMolecule739
left: SmallMolecule299
left: SmallMolecule743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule746
right: SmallMolecule814
right: SmallMolecule492

UniProt:P49199
type: ProteinReference
xref: UnificationXref17966
organism: http://identifiers.org/taxonomy/4530

RNA Polymerase III Transcription
type: Pathway
data source: Provenance1
pathway component: REACT 205222.2
pathway component: REACT 83735.4
pathway component: REACT 33298.5
pathway component: REACT 97380.4
evidence: Evidence1927
xref: RelationshipXref1601
xref: UnificationXref20541
xref: UnificationXref20542
pathway order: PathwayStep1904
pathway order: PathwayStep1897
pathway order: PathwayStep1900
pathway order: PathwayStep1903
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6K990
data source: Provenance1
name: Q6K990
name: Kif2B
xref: UnificationXref23877
feature: FragmentFeature7713
cellular location: GO_0005829
comment: Reactome DB_ID: 6273540
display name: KIF2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3ACI9
data source: Provenance1
name: A3ACI9
name: Kif2B
xref: UnificationXref23879
feature: FragmentFeature7714
cellular location: GO_0005829
comment: Reactome DB_ID: 6273541
display name: KIF2B

Q0DWK6
type: Protein
entity reference: Q0DWK6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIF2C
xref: UnificationXref23889
feature: FragmentFeature7721
cellular location: GO_0005829
comment: Reactome DB_ID: 6273547
display name: MCAK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3ACI9
data source: Provenance1
name: KIF2C
name: A3ACI9
xref: UnificationXref23888
feature: FragmentFeature7720
cellular location: GO_0005829
comment: Reactome DB_ID: 6273546
display name: MCAK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6K990
data source: Provenance1
name: KIF2C
name: Q6K990
xref: UnificationXref23887
feature: FragmentFeature7719
cellular location: GO_0005829
comment: Reactome DB_ID: 6273545
display name: MCAK

Homologues of KIF2C
type: Protein
data source: Provenance1
member physical entity: Q0DWK6
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23890
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273548

Q0DWK6
type: Protein
entity reference: Q0DWK6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Kif2a
xref: UnificationXref23885
feature: FragmentFeature7718
cellular location: GO_0005829
comment: Reactome DB_ID: 6273537
display name: KIF2A

Stoichiometry1639
type: Stoichiometry
physical entity: Complex743
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3ACI9
data source: Provenance1
name: A3ACI9
name: Kif2a
xref: UnificationXref23884
feature: FragmentFeature7717
cellular location: GO_0005829
comment: Reactome DB_ID: 6273535
display name: KIF2A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6K990
data source: Provenance1
name: Q6K990
name: Kif2a
xref: UnificationXref23883
feature: FragmentFeature7716
cellular location: GO_0005829
comment: Reactome DB_ID: 6273533
display name: KIF2A

Stoichiometry1637
type: Stoichiometry
physical entity: SmallMolecule1261
stoichiometric coefficient: 1.0

Homologues of KIF2A
type: Protein
data source: Provenance1
member physical entity: Q0DWK6
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23886
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273538

Stoichiometry1638
type: Stoichiometry
physical entity: SmallMolecule1262
stoichiometric coefficient: 1.0

Q0DWK6
type: Protein
entity reference: Q0DWK6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Kif2B
xref: UnificationXref23881
feature: FragmentFeature7715
cellular location: GO_0005829
comment: Reactome DB_ID: 6273542
display name: KIF2B

Stoichiometry1635
type: Stoichiometry
physical entity: Complex741
stoichiometric coefficient: 1.0

Stoichiometry1636
type: Stoichiometry
physical entity: Protein5846
stoichiometric coefficient: 1.0

Stoichiometry1633
type: Stoichiometry
physical entity: Protein5849
stoichiometric coefficient: 1.0

Stoichiometry1634
type: Stoichiometry
physical entity: SmallMolecule427
stoichiometric coefficient: 1.0

Stoichiometry1631
type: Stoichiometry
physical entity: Complex740
stoichiometric coefficient: 1.0

Stoichiometry1632
type: Stoichiometry
physical entity: SmallMolecule426
stoichiometric coefficient: 1.0

Stoichiometry1630
type: Stoichiometry
physical entity: SmallMolecule1261
stoichiometric coefficient: 1.0

Homologues of KIFC1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23904
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273577

Stoichiometry1626
type: Stoichiometry
physical entity: SmallMolecule1259
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7XN65
data source: Provenance1
name: KIFC1
name: KIFC1_HUMAN
name: Kinesin-like protein KIFC1
name: Q7XN65
xref: UnificationXref23903
feature: FragmentFeature7724
cellular location: GO_0005829
comment: Reactome DB_ID: 6273576
display name: HSET

Stoichiometry1627
type: Stoichiometry
physical entity: Protein5842
stoichiometric coefficient: 1.0

Stoichiometry1628
type: Stoichiometry
physical entity: SmallMolecule1260
stoichiometric coefficient: 1.0

Stoichiometry1629
type: Stoichiometry
physical entity: Protein5846
stoichiometric coefficient: 1.0

Stoichiometry1622
type: Stoichiometry
physical entity: Protein5840
stoichiometric coefficient: 1.0

Stoichiometry1623
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0J9V3
data source: Provenance1
name: KIFC1
name: KIFC1_HUMAN
name: Q0J9V3
name: Kinesin-like protein KIFC1
xref: UnificationXref23901
feature: FragmentFeature7723
cellular location: GO_0005829
comment: Reactome DB_ID: 6273574
display name: HSET

Stoichiometry1624
type: Stoichiometry
physical entity: SmallMolecule1259
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7XAL1
data source: Provenance1
name: KIFC1
name: Q7XAL1
name: KIFC1_HUMAN
name: Kinesin-like protein KIFC1
xref: UnificationXref23899
feature: FragmentFeature7722
cellular location: GO_0005829
comment: Reactome DB_ID: 6273571
display name: HSET

Stoichiometry1625
type: Stoichiometry
physical entity: Protein5841
stoichiometric coefficient: 1.0

Stoichiometry1620
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Stoichiometry1621
type: Stoichiometry
physical entity: Protein5839
stoichiometric coefficient: 1.0

Homologues of CENPE
type: Protein
data source: Provenance1
member physical entity: Q7XCW8
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q0DZ59
member physical entity: OS06T0206700-01
xref: UnificationXref23854
cellular location: GO_0005829
comment: Reactome DB_ID: 6273525
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q651Z7
data source: Provenance1
name: Q651Z7
name: CENP-E
xref: UnificationXref23829
feature: FragmentFeature7696
cellular location: GO_0005829
comment: Reactome DB_ID: 6273496
display name: CENPE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9FES1
data source: Provenance1
name: KIF22
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
name: B9FES1
xref: UnificationXref23818
feature: FragmentFeature7694
cellular location: GO_0005829
comment: Reactome DB_ID: 6273483
display name: KID

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5W7C6
data source: Provenance1
name: KIF11_HUMAN
name: KIF11
name: Kinesin-5
name: Q5W7C6
name: Kinesin-like protein KIF11
xref: UnificationXref23824
feature: FragmentFeature7695
cellular location: GO_0005829
comment: Reactome DB_ID: 6273488
display name: EG5

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6H647
data source: Provenance1
name: Q6H647
name: CENP-E
xref: UnificationXref23835
feature: FragmentFeature7699
cellular location: GO_0005829
comment: Reactome DB_ID: 6273504
display name: CENPE

Stoichiometry1617
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7X7H4
data source: Provenance1
name: Q7X7H4
name: CENP-E
xref: UnificationXref23833
feature: FragmentFeature7698
cellular location: GO_0005829
comment: Reactome DB_ID: 6273502
display name: CENPE

Stoichiometry1618
type: Stoichiometry
physical entity: Protein5838
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9AWM8
data source: Provenance1
name: Q9AWM8
name: CENP-E
xref: UnificationXref23831
feature: FragmentFeature7697
cellular location: GO_0005829
comment: Reactome DB_ID: 6273499
display name: CENPE

Stoichiometry1615
type: Stoichiometry
physical entity: DPN
stoichiometric coefficient: 2.0

Stoichiometry1616
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FW70
data source: Provenance1
name: Q9FW70
name: CENP-E
xref: UnificationXref23843
feature: FragmentFeature7703
cellular location: GO_0005829
comment: Reactome DB_ID: 6273514
display name: CENPE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9G4P1
data source: Provenance1
name: B9G4P1
name: CENP-E
xref: UnificationXref23841
feature: FragmentFeature7702
cellular location: GO_0005829
comment: Reactome DB_ID: 6273511
display name: CENPE

OS06T0206700-01
type: Protein
entity reference: ProteinReference4532
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CENP-E
xref: UnificationXref23839
feature: FragmentFeature7701
cellular location: GO_0005829
comment: Reactome DB_ID: 6273509
display name: CENPE

Stoichiometry1619
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7FB17
data source: Provenance1
name: Q7FB17
name: CENP-E
xref: UnificationXref23837
feature: FragmentFeature7700
cellular location: GO_0005829
comment: Reactome DB_ID: 6273506
display name: CENPE

Stoichiometry1610
type: Stoichiometry
physical entity: Protein5834
stoichiometric coefficient: 1.0

Stoichiometry1613
type: Stoichiometry
physical entity: Protein5837
stoichiometric coefficient: 1.0

Stoichiometry1614
type: Stoichiometry
physical entity: Protein1844
stoichiometric coefficient: 2.0

Stoichiometry1611
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Stoichiometry1612
type: Stoichiometry
physical entity: SmallMolecule213
stoichiometric coefficient: 1.0

Nonhomologous End-joining (NHEJ)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1019
evidence: Evidence1523
xref: UnificationXref16126
xref: UnificationXref16125
xref: RelationshipXref1394
pathway order: PathwayStep1506
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

http://identifiers.org/pubmed/12851482
type: PublicationXref
id: 12851482
author: Poon, RY
author: Woo, RA
db: Pubmed
title: Cyclin-dependent kinases and S phase control in mammalian cells
source: Cell Cycle 2:316-24
year: 2003

Q7XCW8
type: Protein
entity reference: Q7XCW8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CENP-E
xref: UnificationXref23845
feature: FragmentFeature7704
cellular location: GO_0005829
comment: Reactome DB_ID: 6273516
display name: CENPE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3C6F4
data source: Provenance1
name: A3C6F4
name: CENP-E
xref: UnificationXref23847
feature: FragmentFeature7705
cellular location: GO_0005829
comment: Reactome DB_ID: 6273518
display name: CENPE

Q0DZ59
type: Protein
entity reference: Q0DZ59
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CENP-E
xref: UnificationXref23849
feature: FragmentFeature7706
cellular location: GO_0005829
comment: Reactome DB_ID: 6273519
display name: CENPE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6YZ52
data source: Provenance1
name: Q6YZ52
name: CENP-E
xref: UnificationXref23853
feature: FragmentFeature7708
cellular location: GO_0005829
comment: Reactome DB_ID: 6273524
display name: CENPE

Stoichiometry1604
type: Stoichiometry
physical entity: Protein5820
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B7EZT1
data source: Provenance1
name: B7EZT1
name: CENP-E
xref: UnificationXref23851
feature: FragmentFeature7707
cellular location: GO_0005829
comment: Reactome DB_ID: 6273521
display name: CENPE

Stoichiometry1605
type: Stoichiometry
physical entity: Protein5825
stoichiometric coefficient: 2.0

Homologues of KIF9
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: B9FS74
xref: UnificationXref23867
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273565

Stoichiometry1606
type: Stoichiometry
physical entity: Protein5826
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0JLE4
data source: Provenance1
name: Q0JLE4
xref: UnificationXref23859
feature: FragmentFeature7709
cellular location: GO_0005829
comment: Reactome DB_ID: 6273492
display name: KIF18A

Stoichiometry1607
type: Stoichiometry
physical entity: SmallMolecule1249
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q69TG2
data source: Provenance1
name: KIF9_HUMAN
name: Q69TG2
name: Kinesin-like protein KIF9
xref: UnificationXref23866
feature: FragmentFeature7711
cellular location: GO_0005829
comment: Reactome DB_ID: 6273564
display name: KIF9

Stoichiometry1608
type: Stoichiometry
physical entity: Complex725
stoichiometric coefficient: 4.0

B9FS74
type: Protein
entity reference: B9FS74
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIF9_HUMAN
name: Kinesin-like protein KIF9
xref: UnificationXref23864
feature: FragmentFeature7710
cellular location: GO_0005829
comment: Reactome DB_ID: 6273562
display name: KIF9

Stoichiometry1609
type: Stoichiometry
physical entity: SmallMolecule963
stoichiometric coefficient: 4.0

Homologues of KIF2B
type: Protein
data source: Provenance1
member physical entity: Q0DWK6
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23882
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273543

B9GE13
type: Protein
entity reference: B9GE13
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIF15_HUMAN
name: Kinesin-like protein KIF15
xref: UnificationXref23872
feature: FragmentFeature7712
cellular location: GO_0005829
comment: Reactome DB_ID: 6273529
display name: KIF15

Stoichiometry1600
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 2.0

Stoichiometry1601
type: Stoichiometry
physical entity: Complex726
stoichiometric coefficient: 4.0

Stoichiometry1602
type: Stoichiometry
physical entity: SmallMolecule1248
stoichiometric coefficient: 4.0

Stoichiometry1603
type: Stoichiometry
physical entity: Complex720
stoichiometric coefficient: 2.0

Dedicator of cytokinesis protein 8
type: Protein
entity reference: Q10M07
data source: Provenance1
name: Q10M07
name: Note: the coordinates are copied over from Homo sapiens.
name: DOCK8_HUMAN
xref: UnificationXref23786
feature: FragmentFeature7681
cellular location: GO_0005829
comment: Reactome DB_ID: 6273704
display name: DOCK8

Dedicator of cytokinesis protein 8
type: Protein
entity reference: Q8H7M0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8H7M0
name: DOCK8_HUMAN
xref: UnificationXref23785
feature: FragmentFeature7680
cellular location: GO_0005829
comment: Reactome DB_ID: 6273703
display name: DOCK8

Dedicator of cytokinesis protein 8
type: Protein
entity reference: Q0DS76
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DOCK8_HUMAN
name: Q0DS76
xref: UnificationXref23784
feature: FragmentFeature7679
cellular location: GO_0005829
comment: Reactome DB_ID: 6273702
display name: DOCK8

B9F8Y9
type: Protein
entity reference: B9F8Y9
data source: Provenance1
name: Dedicator of cytokinesis protein 8
name: Note: the coordinates are copied over from Homo sapiens.
name: DOCK8_HUMAN
xref: UnificationXref23783
feature: FragmentFeature7678
cellular location: GO_0005829
comment: Reactome DB_ID: 6273701
display name: DOCK8

Homologues of DOCK8
type: Protein
data source: Provenance1
member physical entity: Dedicator of cytokinesis protein 8
member physical entity: B9F8Y9
xref: UnificationXref23787
cellular location: GO_0005829
comment: Reactome DB_ID: 6273705
comment: Converted from EntitySet in Reactome

Q10M07
type: Protein
entity reference: Q10M07
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dedicator of cytokinesis protein 11
name: DOC11_HUMAN
xref: UnificationXref23781
feature: FragmentFeature7677
cellular location: GO_0005829
comment: Reactome DB_ID: 6273699
display name: DOCK11

Stoichiometry1682
type: Stoichiometry
physical entity: Protein941
stoichiometric coefficient: 1.0

Stoichiometry1683
type: Stoichiometry
physical entity: Protein938
stoichiometric coefficient: 1.0

Stoichiometry1680
type: Stoichiometry
physical entity: PhysicalEntity35
stoichiometric coefficient: 1.0

Stoichiometry1681
type: Stoichiometry
physical entity: Protein5890
stoichiometric coefficient: 1.0

Stoichiometry1679
type: Stoichiometry
physical entity: PhysicalEntity179
stoichiometric coefficient: 1.0

Stoichiometry1678
type: Stoichiometry
physical entity: Complex761
stoichiometric coefficient: 1.0

Stoichiometry1677
type: Stoichiometry
physical entity: Complex760
stoichiometric coefficient: 1.0

Stoichiometry1676
type: Stoichiometry
physical entity: PhysicalEntity178
stoichiometric coefficient: 1.0

Stoichiometry1675
type: Stoichiometry
physical entity: DNA Polymerase delta tetramer (name copied from entity in Homo sapiens)
stoichiometric coefficient: 1.0

Stoichiometry1674
type: Stoichiometry
physical entity: PhysicalEntity177
stoichiometric coefficient: 1.0

Stoichiometry1673
type: Stoichiometry
physical entity: Protein5890
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8H7M0
data source: Provenance1
name: Dedicator of cytokinesis protein 6
name: Q8H7M0
name: DOCK6_HUMAN
xref: UnificationXref23790
feature: FragmentFeature7684
cellular location: GO_0005829
comment: Reactome DB_ID: 6273708
display name: DOCK6

Q10M07
type: Protein
entity reference: Q10M07
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dedicator of cytokinesis protein 6
name: DOCK6_HUMAN
xref: UnificationXref23791
feature: FragmentFeature7685
cellular location: GO_0005829
comment: Reactome DB_ID: 6273709
display name: DOCK6

B9F8Y9
type: Protein
entity reference: B9F8Y9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dedicator of cytokinesis protein 6
name: DOCK6_HUMAN
xref: UnificationXref23788
feature: FragmentFeature7682
cellular location: GO_0005829
comment: Reactome DB_ID: 6273706
display name: DOCK6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DS76
data source: Provenance1
name: Dedicator of cytokinesis protein 6
name: Q0DS76
name: DOCK6_HUMAN
xref: UnificationXref23789
feature: FragmentFeature7683
cellular location: GO_0005829
comment: Reactome DB_ID: 6273707
display name: DOCK6

http://identifiers.org/pubmed/9153422
type: PublicationXref
id: 9153422
author: Batelier, G
author: Soulié, S
author: Melki, R
author: Williams RC, Jr
db: Pubmed
title: Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
source: Biochemistry 36:5817-26
year: 1997

Homologues of DOCK6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q10M07
member physical entity: B9F8Y9
xref: UnificationXref23792
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273710

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C7J143
data source: Provenance1
name: C7J143
name: Kinesin light chain 2
name: KLC2_HUMAN
xref: UnificationXref23802
feature: FragmentFeature7688
cellular location: GO_0005829
comment: Reactome DB_ID: 6273449
display name: KLC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F9W301
data source: Provenance1
name: Kinesin heavy chain isoform 5A
name: Neuronal kinesin heavy chain
name: F9W301
name: KIF5A_HUMAN
xref: UnificationXref23798
feature: FragmentFeature7686
cellular location: GO_0005829
comment: Reactome DB_ID: 6273453
display name: KIF5A

Kinesin-1 heavy chain
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref23799
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273454

Kinesin light chain 1
type: Protein
entity reference: C7J143
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: C7J143
name: KLC1_HUMAN
xref: UnificationXref23801
feature: FragmentFeature7687
cellular location: GO_0005829
comment: Reactome DB_ID: 6273448
display name: KLC1

Kinesin-1 light chains
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Kinesin light chain 1
xref: UnificationXref23803
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273450

Stoichiometry1670
type: Stoichiometry
physical entity: Protein5887
stoichiometric coefficient: 1.0

Stoichiometry1671
type: Stoichiometry
physical entity: Protein5890
stoichiometric coefficient: 1.0

Stoichiometry1672
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1667
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1666
type: Stoichiometry
physical entity: PhysicalEntity176
stoichiometric coefficient: 1.0

Stoichiometry1669
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1668
type: Stoichiometry
physical entity: Protein5873
stoichiometric coefficient: 1.0

Stoichiometry1663
type: Stoichiometry
physical entity: Protein5887
stoichiometric coefficient: 1.0

Stoichiometry1662
type: Stoichiometry
physical entity: Protein5873
stoichiometric coefficient: 1.0

Stoichiometry1665
type: Stoichiometry
physical entity: Protein5887
stoichiometric coefficient: 1.0

Stoichiometry1664
type: Stoichiometry
physical entity: PhysicalEntity175
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6L512
data source: Provenance1
name: KIF22
name: KIF22_HUMAN
name: Q6L512
name: Kinesin-like protein KIF22
xref: UnificationXref23810
feature: FragmentFeature7690
cellular location: GO_0005829
comment: Reactome DB_ID: 6273474
display name: KID

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C7IYS1
data source: Provenance1
name: KIF22
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
name: C7IYS1
xref: UnificationXref23812
feature: FragmentFeature7691
cellular location: GO_0005829
comment: Reactome DB_ID: 6273477
display name: KID

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B9F023
data source: Provenance1
name: KIF22
name: B9F023
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
xref: UnificationXref23814
feature: FragmentFeature7692
cellular location: GO_0005829
comment: Reactome DB_ID: 6273479
display name: KID

Q6K765
type: Protein
entity reference: Q6K765
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIF22
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
xref: UnificationXref23816
feature: FragmentFeature7693
cellular location: GO_0005829
comment: Reactome DB_ID: 6273481
display name: KID

Homologues of KIF22
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q6K765
xref: UnificationXref23819
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273484

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7XMJ2
data source: Provenance1
name: KIF22
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
name: Q7XMJ2
xref: UnificationXref23808
feature: FragmentFeature7689
cellular location: GO_0005829
comment: Reactome DB_ID: 6273471
display name: KID

Stoichiometry1660
type: Stoichiometry
physical entity: PhysicalEntity173
stoichiometric coefficient: 1.0

Stoichiometry1661
type: Stoichiometry
physical entity: PhysicalEntity174
stoichiometric coefficient: 1.0

Stoichiometry1654
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1653
type: Stoichiometry
physical entity: Protein5865
stoichiometric coefficient: 1.0

Stoichiometry1652
type: Stoichiometry
physical entity: Protein5869
stoichiometric coefficient: 1.0

Stoichiometry1651
type: Stoichiometry
physical entity: PhysicalEntity171
stoichiometric coefficient: 1.0

Stoichiometry1658
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1657
type: Stoichiometry
physical entity: Protein5869
stoichiometric coefficient: 1.0

Stoichiometry1656
type: Stoichiometry
physical entity: PhysicalEntity172
stoichiometric coefficient: 1.0

Stoichiometry1655
type: Stoichiometry
physical entity: Protein5862
stoichiometric coefficient: 1.0

Stoichiometry1659
type: Stoichiometry
physical entity: Protein5873
stoichiometric coefficient: 1.0

JHD2C_HUMAN
type: Protein
entity reference: B9G3E2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
name: B9G3E2
xref: UnificationXref23756
feature: FragmentFeature7666
cellular location: GO_0005654
comment: Reactome DB_ID: 6273653
display name: JMJD1C

JHD2C_HUMAN
type: Protein
entity reference: ProteinReference4511
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: OS02T0109501-00
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
xref: UnificationXref23758
feature: FragmentFeature7667
cellular location: GO_0005654
comment: Reactome DB_ID: 6273656
display name: JMJD1C

JHD2C_HUMAN
type: Protein
entity reference: Q6K7P0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q6K7P0
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
xref: UnificationXref23754
feature: FragmentFeature7665
cellular location: GO_0005654
comment: Reactome DB_ID: 6273650
display name: JMJD1C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference4513
data source: Provenance1
name: GTP:AMP phosphotransferase, mitochondrial
name: Adenylate kinase 3
name: OS04T0671100-01
name: KAD3_HUMAN
xref: UnificationXref23765
feature: FragmentFeature7669
cellular location: GO_0005759
comment: Reactome DB_ID: 6273664
display name: AK3

JHD2C_HUMAN
type: Protein
entity reference: Q6H405
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Probable JmjC domain-containing histone demethylation protein 2C
name: Jumonji domain-containing protein 1C
name: Q6H405
xref: UnificationXref23760
feature: FragmentFeature7668
cellular location: GO_0005654
comment: Reactome DB_ID: 6273658
display name: JMJD1C

B9F8Y9
type: Protein
entity reference: B9F8Y9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dedicator of cytokinesis protein 9
name: DOCK9_HUMAN
xref: UnificationXref23770
feature: FragmentFeature7670
cellular location: GO_0005829
comment: Reactome DB_ID: 6273688
display name: DOCK9

Agmatine biosynthesis
type: Pathway
data source: Provenance1
pathway component: Arginine<=>Agmatine+CO2
pathway component: Agmatine + H2O <=> putrescine + urea
evidence: Evidence1296
xref: RelationshipXref1211
xref: UnificationXref13959
xref: UnificationXref13958
pathway order: PathwayStep1280
pathway order: PathwayStep1281
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/4530

Homologues of DOCK9
type: Protein
data source: Provenance1
member physical entity: B9F8Y9
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q10M07
xref: UnificationXref23777
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6273695

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8H7M0
data source: Provenance1
name: Dedicator of cytokinesis protein 9
name: DOCK9_HUMAN
name: Q8H7M0
xref: UnificationXref23774
feature: FragmentFeature7672
cellular location: GO_0005829
comment: Reactome DB_ID: 6273692
display name: DOCK9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0DS76
data source: Provenance1
name: Dedicator of cytokinesis protein 9
name: DOCK9_HUMAN
name: Q0DS76
xref: UnificationXref23772
feature: FragmentFeature7671
cellular location: GO_0005829
comment: Reactome DB_ID: 6273690
display name: DOCK9

Q10M07
type: Protein
entity reference: Q10M07
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dedicator of cytokinesis protein 9
name: DOCK9_HUMAN
xref: UnificationXref23776
feature: FragmentFeature7673
cellular location: GO_0005829
comment: Reactome DB_ID: 6273694
display name: DOCK9

Stoichiometry1650
type: Stoichiometry
physical entity: Protein5869
stoichiometric coefficient: 1.0

Stoichiometry1641
type: Stoichiometry
physical entity: Protein5862
stoichiometric coefficient: 1.0