ANPEP hydrolyzes Angiotensin III to Angiotensin IV
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref67
xref: http://identifiers.org/pubmed/1978675
xref: UnificationXref68
left: ANG2-8
comment: ANPEP from rabbit renal membranes hydrolyzes angiotensin III to yield angiotensin IV.
comment: Authored: May, B, 2011-11-29
comment: Edited: May, B, 2011-11-29
comment: Reviewed: Joseph, J, 2012-08-06
right: Angiotensin-(3-8)

Prostaglandin F2a
type: SmallMoleculeReference
name: Prostaglandin F2alpha
name: Enzaprost
name: Prostin F 2 alpha
name: Prostaglandin F2
name: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
name: PGF2a
name: Prostarmon F
name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-,(5Z,9a,11a,13E,15S)-
name: Prostaglandin F2alpha [ChEBI:8516]
name: U 14583
name: 9a,11a-PGF2
name: Dinoprost
name: Protamodin
name: 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-
name: Panacelan
name: Cyclosin
name: (+)-Prostaglandin F2a
name: Enzaprost F
name: 7-[3, 5-dihydroxy-2-(3-hydroxy-1-octenyl) cyclopentyl]-5-heptenoic acid
name: Amoglandin
xref: UnificationXref138

UnificationXref180
type: UnificationXref
id: 421933
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421933

Association of Pak2 with Cdc42-GTP
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/10075701
xref: UnificationXref76
xref: http://identifiers.org/pubmed/16204230
xref: UnificationXref77
left: partially auto-phosphorylated PAK-2 (inactive)
left: CDC42-GTP
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Traugh, JA, Jung, JH, 2008-02-06 09:37:35
comment: Inactive PAK-2 is partially autophosphorylated at 5 serine sites in the regulatory domain (Gatti et al. 1999). PAK-2 associates with Cdc42(GTP) by binding to the p21 binding domain (PBD) of PAK-2 (Jung and Traugh, 2005).
comment: Reviewed: Jakobi, R, 2008-02-25 02:02:42
right: Inactive Pak2:Cdc42-GTP complex

Stoichiometry18
type: Stoichiometry
physical entity: G alpha (s):GTP
stoichiometric coefficient: 1.0

UnificationXref181
type: UnificationXref
id: REACT_24600
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24600.1

Cleavage of PAK-2 at 212
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.4.22
xref: UnificationXref40
xref: UnificationXref41
xref: http://identifiers.org/pubmed/9786869
xref: http://identifiers.org/pubmed/12853446
left: partially auto-phosphorylated PAK-2 (inactive)
comment: Edited: Matthews, L, 2008-06-02 08:04:50
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: p21-activated protein kinase (PAK-2), also known as gamma-PAK, is cleaved by caspase-3 during apoptosis and plays a role in regulating cell death. Cleavage produces two peptides; 1-212 containing most of the regulatory domain and 213-524 containing 34 amino acids of the regulatory domain as well as the catalytic domain (Walter et al., 1998). Proteolytic cleavage of PAK by caspase-3 creates the constitutively active PAK-2p34 fragment (Jakobi et al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.
right: Auto-phosphorylated PAK-2 (p27 regulatory fragment)
right: PAK-2p34

Prostaglandin E2 [ChEBI:8512]
type: SmallMoleculeReference
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
name: Prostaglandin E2
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
xref: UnificationXref135

Stoichiometry19
type: Stoichiometry
physical entity: Heterotrimeric G-protein Gs (active)
stoichiometric coefficient: 1.0

UnificationXref182
type: UnificationXref
id: 421937
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421937

Digestion of trehalose to yield glucose
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.28
xref: UnificationXref58
xref: UnificationXref57
xref: http://identifiers.org/pubmed/1697585
xref: http://identifiers.org/pubmed/9427547
xref: http://identifiers.org/pubmed/6466686
participant stoichiometry: Stoichiometry7
left: alpha,alpha-trehalose
left: water
display name: trehalose + H2O => 2 D-glucose
comment: Reviewed: Nichols, BL, 2007-01-15 21:51:24
comment: Authored: D'Eustachio, P, 2006-11-03 14:36:07
comment: Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and the protein product of the clone has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.
right: alpha-D-glucose

reEF1A complexes with GTP
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref12
xref: UnificationXref13
left: reEF1A
left: Guanosine 5'-triphosphate
comment: At the beginning of this reaction, 1 molecule of 'GTP', and 1 molecule of 'reEF1A' are present. At the end of this reaction, 1 molecule of 'reEF1A:GTP' is present. This reaction is mediated by the 'guanyl nucleotide binding activity' of 'reEF1A'.
right: reEF1A:GTP

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/10075701
xref: UnificationXref26
xref: UnificationXref27
xref: http://identifiers.org/pubmed/16204230
participant stoichiometry: Stoichiometry4
participant stoichiometry: Stoichiometry3
left: PAK-2
left: Adenosine 5'-triphosphate
comment: Edited: Matthews, L, 2008-05-28 22:54:51
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-08 00:29:01
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: Inactive PAK-2 can be partially autophosphorylated in the regulatory region without being activated (Gatti et al. 1999).
right: partially auto-phosphorylated PAK-2 (inactive)
right: Adenosine 5'-diphosphate

UnificationXref187
type: UnificationXref
id: REACT_24463
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24463.1

Stoichiometry12
type: Stoichiometry
physical entity: G1TBB5_RABIT
stoichiometric coefficient: 2.0

UnificationXref188
type: UnificationXref
id: 421958
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421958

Stoichiometry13
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein subunit gamma-2
stoichiometric coefficient: 1.0

UnificationXref189
type: UnificationXref
id: REACT_24455
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24455.1

Stoichiometry10
type: Stoichiometry
physical entity: partially auto-phosphorylated PAK-2 (inactive)
stoichiometric coefficient: 1.0

Stoichiometry11
type: Stoichiometry
physical entity: CDC42-GTP
stoichiometric coefficient: 1.0

Stoichiometry16
type: Stoichiometry
physical entity: G(s) alpha subunit
stoichiometric coefficient: 1.0

UnificationXref183
type: UnificationXref
id: REACT_24740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24740.1

(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate [ChEBI:249]
type: SmallMoleculeReference
name: (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
xref: UnificationXref149

Stoichiometry17
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

UnificationXref184
type: UnificationXref
id: 113572
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113572

UnificationXref185
type: UnificationXref
id: REACT_3646
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3646.1

Stoichiometry14
type: Stoichiometry
physical entity: G-protein beta subunit
stoichiometric coefficient: 1.0

(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
type: SmallMoleculeReference
name: Prostaglandin D2
name: (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate [ChEBI:246]
xref: UnificationXref132

UnificationXref186
type: UnificationXref
id: 421955
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421955

Stoichiometry15
type: Stoichiometry
physical entity: G-protein beta:gamma complex
stoichiometric coefficient: 1.0

G-protein beta subunit
type: Protein
data source: Reactome
member physical entity: GBB5_RABIT
xref: UnificationXref172
xref: UnificationXref173
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 421945

Stoichiometry4
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 5.0

G1TBB5_RABIT
type: Protein
entity reference: UniProt:G1TBB5
data source: Reactome
xref: UnificationXref161
xref: UnificationXref162
cellular location: cytosol
comment: Reactome DB_ID: 2142728
display name: HPGD

Stoichiometry3
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 5.0

Stoichiometry2
type: Stoichiometry
physical entity: reEF1A
stoichiometric coefficient: 1.0

K48polyUb-phospho-PAK-2p34(Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref124
xref: UnificationXref123
feature: ModificationFeature7
feature: ModificationFeature8
feature: FragmentFeature26
cellular location: cytosol
comment: Reactome DB_ID: 3095872

Stoichiometry1
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

ubiquitin (UBC 9)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref118
xref: UnificationXref119
feature: FragmentFeature25
cellular location: cytosol
comment: Reactome DB_ID: 939165
display name: UBC(609-684)

Stoichiometry20
type: Stoichiometry
physical entity: ADRB2_MOUSE
stoichiometric coefficient: 1.0

Stoichiometry8
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

Stoichiometry7
type: Stoichiometry
physical entity: alpha-D-glucose
stoichiometric coefficient: 2.0

Stoichiometry6
type: Stoichiometry
physical entity: Caspase-3 (small subunit)
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: Caspase-3 (large subunit)
stoichiometric coefficient: 1.0

GPX1_RABIT
type: Protein
entity reference: UniProt:P11909 GPX1
data source: Reactome
xref: UnificationXref307
xref: UnificationXref308
feature: FragmentFeature29
cellular location: cytosol
comment: Reactome DB_ID: 2142684
display name: GPX1

ADRB2_MOUSE
type: Protein
entity reference: UniProt:P18762 Adrb2
data source: Reactome
name: Beta-2 adrenergic receptor
xref: UnificationXref192
xref: UnificationXref193
feature: FragmentFeature28
cellular location: plasma membrane
comment: Reactome DB_ID: 421951
display name: Adrb2

Stoichiometry9
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

G(s) alpha 2
type: Protein
entity reference: guanine nucleotide-binding protein Gs alpha2
data source: Reactome
xref: UnificationXref180
xref: UnificationXref181
cellular location: plasma membrane
comment: Reactome DB_ID: 421933

Q6X973_RABIT
type: Protein
entity reference: Q6X973_RABIT
data source: Reactome
xref: UnificationXref177
xref: UnificationXref178
cellular location: plasma membrane
comment: Reactome DB_ID: 421934
display name: G(s) alpha 1

PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.141
xref: UnificationXref165
xref: UnificationXref166
xref: http://identifiers.org/pubmed/3954355
left: DPN
left: PGD2/E2/F2a
comment: Authored: Williams, MG, 2012-02-24
comment: Edited: Williams, MG, 2012-02-24
comment: Reviewed: Rush, MG, 2012-11-10
comment: In rabbits, 15-hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Bergholte & Okita 1986).
right: 15k-PGD2/E2/F2a
right: NADH
right: proton

G(s) alpha subunit
type: Protein
data source: Reactome
member physical entity: G(s) alpha 2
member physical entity: Q6X973_RABIT
xref: UnificationXref182
xref: UnificationXref183
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 421937

Ubiquitination of PAK-2p34
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.2.19
xref: http://identifiers.org/pubmed/19754430
xref: UnificationXref127
xref: UnificationXref128
xref: http://identifiers.org/pubmed/12853446
left: phospho-PAK-2p34(Thr 402)
left: ubiquitin
comment: PAK-2p34 is ubiquitinated prior to degradation (Jakobi et al., 2003). Here, ubiquitination of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm. Evidence for this reaction comes from experiments using both human and rabbit proteins. The polyubiquitin synthesized in the reaction is inferred to contain lysine-48 (K48) linkages because the modified protein is targeted to the proteasome (Komander 2009).
comment: Edited: Matthews, L, 2008-05-23 07:17:49
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
right: K48polyUb-phospho-PAK-2p34(Thr 402)

GBB5_RABIT
type: Protein
entity reference: GNB5
data source: Reactome
name: Guanine nucleotide-binding protein subunit beta-5
xref: UnificationXref170
xref: UnificationXref171
feature: FragmentFeature27
cellular location: plasma membrane
comment: Reactome DB_ID: 421942
display name: GNB5

Proteolytic PAK-2p34 fragment translocates to the nucleus
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref85
xref: UnificationXref84
xref: http://identifiers.org/pubmed/12853446
left: phospho-PAK-2p34 (Thr 402)
comment: Edited: Matthews, L, 2008-06-03 00:23:29
comment: The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
right: phospho-PAK-2p34 (Thr 402)

Stoichiometry29
type: Stoichiometry
physical entity: reEF1A
stoichiometric coefficient: 1.0

UnificationXref192
type: UnificationXref
id: 421951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421951

UnificationXref193
type: UnificationXref
id: REACT_24288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24288.1

UnificationXref190
type: UnificationXref
id: 10090
db: NCBI Taxonomy

UnificationXref191
type: UnificationXref
id: P18762
db: UniProt

Stoichiometry21
type: Stoichiometry
physical entity: Isoprotenerol
stoichiometric coefficient: 1.0

Stoichiometry22
type: Stoichiometry
physical entity: Aminoacyl-tRNA
stoichiometric coefficient: 1.0

Stoichiometry23
type: Stoichiometry
physical entity: reEF1A:GTP
stoichiometric coefficient: 1.0

UnificationXref198
type: UnificationXref
id: REACT_24441
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24441.1

Stoichiometry24
type: Stoichiometry
physical entity: reEF1A:GTP:Aminoacyl-tRNA complex
stoichiometric coefficient: 1.0

UnificationXref199
type: UnificationXref
id: 421961
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421961

Stoichiometry25
type: Stoichiometry
physical entity: messenger RNA
stoichiometric coefficient: 1.0

UnificationXref196
type: UnificationXref
id: REACT_24559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24559.2

Stoichiometry26
type: Stoichiometry
physical entity: 80S ribosome
stoichiometric coefficient: 1.0

UnificationXref197
type: UnificationXref
id: 421959
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421959

Guanosine 5'-diphosphate
type: SmallMoleculeReference
name: GDP
name: Guanosine diphosphate
name: GDP [ChEBI:17552]
xref: UnificationXref278

Stoichiometry27
type: Stoichiometry
physical entity: fMet-tRNA
stoichiometric coefficient: 1.0

UnificationXref194
type: UnificationXref
id: CHEBI:4495
db: ChEBI

Stoichiometry28
type: Stoichiometry
physical entity: 80S:Met-tRNAi:mRNA
stoichiometric coefficient: 1.0

UnificationXref195
type: UnificationXref
id: 421954
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421954

ubiquitin (UBB 2)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
xref: UnificationXref97
xref: UnificationXref98
feature: FragmentFeature15
cellular location: cytosol
comment: Reactome DB_ID: 939213
display name: UBB(77-152)

UBC(1-76)
type: Protein
entity reference: UBC
data source: Reactome
name: ubiquitin (UBC 1)
xref: UnificationXref102
xref: UnificationXref103
feature: FragmentFeature17
cellular location: cytosol
comment: Reactome DB_ID: 939188
display name: UBC

ubiquitin (UBB 3)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
xref: UnificationXref99
xref: UnificationXref100
feature: FragmentFeature16
cellular location: cytosol
comment: Reactome DB_ID: 939230
display name: UBB(153-228)

Stoichiometry31
type: Stoichiometry
physical entity: 80S:Met-tRNAi:mRNA
stoichiometric coefficient: 1.0

Stoichiometry30
type: Stoichiometry
physical entity: Guanosine 5'-diphosphate
stoichiometric coefficient: 1.0

ubiquitin (UBC 7)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref114
xref: UnificationXref115
feature: FragmentFeature23
cellular location: cytosol
comment: Reactome DB_ID: 939184
display name: UBC(457-532)

ubiquitin (UBC 6)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref113
xref: UnificationXref112
feature: FragmentFeature22
cellular location: cytosol
comment: Reactome DB_ID: 939191
display name: UBC(381-456)

http://identifiers.org/pubmed/10549853
type: PublicationXref
id: 10549853
author: Kunimoto, M
author: Imai, H
author: Arai, M
author: Chiba, N
author: Nakagawa, Y
author: Oshima, G
author: Narashima, K
db: Pubmed
title: Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages
source: Biol Pharm Bull 22:1047-51
year: 1999

ubiquitin (UBC 8)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref116
xref: UnificationXref117
feature: FragmentFeature24
cellular location: cytosol
comment: Reactome DB_ID: 939239
display name: UBC(533-608)

ubiquitin (UBC 3)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref106
xref: UnificationXref107
feature: FragmentFeature19
cellular location: cytosol
comment: Reactome DB_ID: 939258
display name: UBC(153-228)

ubiquitin (UBC 2)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref105
xref: UnificationXref104
feature: FragmentFeature18
cellular location: cytosol
comment: Reactome DB_ID: 939164
display name: UBC(77-152)

ubiquitin (UBC 5)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref111
xref: UnificationXref110
feature: FragmentFeature21
cellular location: cytosol
comment: Reactome DB_ID: 939232
display name: UBC(305-380)

ubiquitin (UBC 4)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref109
xref: UnificationXref108
feature: FragmentFeature20
cellular location: cytosol
comment: Reactome DB_ID: 939192
display name: UBC(229-304)

AMPN_RABIT
type: Protein
entity reference: ANPEP
data source: Reactome
xref: UnificationXref66
xref: UnificationXref65
feature: FragmentFeature10
cellular location: plasma membrane
comment: Reactome DB_ID: 2022347
display name: ANPEP

Angiotensin-(3-8)
type: Protein
entity reference: SERPINA8
data source: Reactome
name: ANGT_HUMAN
name: ANG3-8
name: Angiotensin IV
name: AGT(36-41)
xref: UnificationXref63
xref: UnificationXref62
feature: FragmentFeature9
cellular location: extracellular region
comment: Reactome DB_ID: 2022355
display name: AGT

phospho-PAK-2p34(Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref87
xref: UnificationXref86
feature: ModificationFeature7
feature: FragmentFeature11
cellular location: cytosol
comment: Reactome DB_ID: 211641

phospho-PAK-2p34 (Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref82
xref: UnificationXref83
feature: ModificationFeature7
cellular location: nucleoplasm
comment: Reactome DB_ID: 266149

phospho-PAK-2p34 (Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref80
xref: UnificationXref79
feature: ModificationFeature7
cellular location: cytosol
comment: Reactome DB_ID: 266144

Cdc42
type: Protein
entity reference: UniProt:Q5U814 Small GTP binding protein CDC42
data source: Reactome
xref: UnificationXref70
xref: UnificationXref71
cellular location: cytosol
comment: Reactome DB_ID: 213296

UBB(1-76)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
name: ubiquitin (UBB 1)
xref: UnificationXref95
xref: UnificationXref96
feature: FragmentFeature14
cellular location: cytosol
comment: Reactome DB_ID: 939214
display name: UBB

UBA52(1-76)
type: Protein
entity reference: UniProt:P62987 UBA52
data source: Reactome
name: ubiquitin (UBA52)
xref: UnificationXref92
xref: UnificationXref93
feature: FragmentFeature13
cellular location: cytosol
comment: Reactome DB_ID: 939203
display name: UBA52

RPS27A(1-76)
type: Protein
entity reference: UBA80
data source: Reactome
name: ubiquitin (RPS27A)
xref: UnificationXref90
xref: UnificationXref89
feature: FragmentFeature12
cellular location: cytosol
comment: Reactome DB_ID: 939205
display name: RPS27A

ubiquitin
type: Protein
data source: Reactome
member physical entity: ubiquitin (UBB 2)
member physical entity: UBC(1-76)
member physical entity: ubiquitin (UBC 9)
member physical entity: ubiquitin (UBB 3)
member physical entity: ubiquitin (UBC 7)
member physical entity: ubiquitin (UBC 6)
member physical entity: ubiquitin (UBC 8)
member physical entity: UBB(1-76)
member physical entity: ubiquitin (UBC 3)
member physical entity: UBA52(1-76)
member physical entity: ubiquitin (UBC 2)
member physical entity: RPS27A(1-76)
member physical entity: ubiquitin (UBC 5)
member physical entity: ubiquitin (UBC 4)
xref: UnificationXref121
xref: UnificationXref120
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 113595
display name: Ub

UnificationXref5
type: UnificationXref
id: 9986
db: NCBI Taxonomy

UnificationXref4
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref7
type: UnificationXref
id: 159543
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159543

Ghr internalization
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/17488973
xref: UnificationXref322
xref: UnificationXref321
left: Growth hormone receptor
comment: Reviewed: Herington, AC, 2011-06-13
comment: Cell surface levels of GHR are the primary determinant of GH responsiveness. This is modulated partly by endocytosis and lysosomal degradation. This downregulation is strongly inhibited by the association of JAK2 with the receptor, and by GH if JAK2 is prevented from signaling, but markedly enhanced by GH if JAK2 is kinase active. GH down-regulation also requires GHR tyrosine phosphorylation (Deng et al. 2007) and is believed to be mediated by GHR ubiquitination and proteasomal degradation.
comment: Reviewed: Waters, MJ, 2011-06-23
comment: Authored: Jupe, S, 2010-10-14
comment: Edited: Jupe, S, 2011-06-10

UnificationXref6
type: UnificationXref
id: P68105
db: UniProt

reEF1A:GTP:Aminoacyl-tRNA ternary complex formation
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref314
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref313
left: Aminoacyl-tRNA
left: reEF1A:GTP
comment: At the beginning of this reaction, 1 molecule of 'Aminoacyl-tRNA', and 1 molecule of 'reEF1A:GTP' are present. At the end of this reaction, 1 molecule of 'reEF1A:GTP:Aminoacyl-tRNA complex' is present.
right: reEF1A:GTP:Aminoacyl-tRNA complex

UnificationXref9
type: UnificationXref
id: 159530
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159530

5-HETE
type: SmallMoleculeReference
name: 5-Hydroxyeicosatetraenoate
name: 5-Hydroxyeicosatetraenoate [ChEBI:2068]
xref: UnificationXref301

5S-HpETE is reduced to 5S-HETE by GPX1
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.9
xref: UnificationXref312
xref: http://identifiers.org/pubmed/10549853
xref: UnificationXref311
participant stoichiometry: Stoichiometry33
left: (S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
left: gamma-L-Glutamyl-L-cysteinyl-glycine
comment: Authored: Williams, MG, 2012-02-24
comment: Edited: Williams, MG, 2012-02-24
comment: Reviewed: Rush, MG, 2012-11-10
comment: The cytosol of rabbit lung alveolar macrophages contains a high amount of glutathione peroxidase 1 (GPX1), which reduces 5-hydroperoxyeicosatetraenoic acid (5-HPETE) to 5-hydroxyeicosatetraenoic acid (5-HETE) in the presence of glutathione (GSH) (Chiba et al. 1999). Current literature suggests that 5-HETE itself does not appear to play a significant role in biological signalling. However, it can be further oxidised by a 5-hydroxy-eicosatetraenoic acid dehydrogenase (5-HEDH) to form the bioactive 5-oxo-eicosatetraenoic acid (5-oxoETE) aka 5-KETE.
right: glutathione disulfide
right: Water
right: 5S-HETE

UnificationXref8
type: UnificationXref
id: REACT_4440
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4440.1

Aminoacyl-tRNA binds to the ribosome at the A-site
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref290
xref: UnificationXref291
left: reEF1A:GTP:Aminoacyl-tRNA complex
left: 80S:Met-tRNAi:mRNA
comment: At the beginning of this reaction, 1 molecule of '80S:Met-tRNAi:mRNA', and 1 molecule of 'reEF1A:GTP:Aminoacyl-tRNA complex' are present. At the end of this reaction, 1 molecule of '80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP' is present.
right: 80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP

http://identifiers.org/pubmed/10075701
type: PublicationXref
id: 10075701
author: Traugh, JA
author: Huang, Z
author: Tuazon, PT
author: Gatti, A
db: Pubmed
title: Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
source: J Biol Chem 274:8022-8
year: 1999

Hydrolysis of reEF1A:GTP
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.5.1
EC number: 3.6.5.3
EC number: 3.6.5.2
EC number: 3.6.5.4
xref: UnificationXref289
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref288
left: 80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP
comment: At the beginning of this reaction, 1 molecule of '80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP' is present. At the end of this reaction, 1 molecule of 'reEF1A:GDP', 1 molecule of '80S:Met-tRNAi:mRNA:aa-tRNA', and 1 molecule of 'Orthophosphate' are present. This reaction is mediated by the 'GTPase activity' of '80S ribosome'.
right: reEF1A:GDP
right: 80S:Met-tRNAi:mRNA:aa-tRNA
right: Phosphate

Autophosphorylation of PAK-2p34
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref201
xref: UnificationXref202
xref: http://identifiers.org/pubmed/9786869
left: PAK-2p34
left: Adenosine 5'-triphosphate
comment: Edited: Matthews, L, 2008-05-23 07:02:49
comment: Edited: Matthews, L, 2008-02-06 20:56:00
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: Activation of PAK-2p34 coincides with autophosphorylation of Thr 402 in the the catalytic domain (Walter et al., 1998).
right: phospho-PAK-2p34(Thr 402)
right: Adenosine 5'-diphosphate

Dissociation of beta-2 adrenergic receptor:Gs complex
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref200
xref: http://identifiers.org/pubmed/8736705
xref: http://identifiers.org/pubmed/3141418
xref: UnificationXref199
left: Isoprotenerol:beta-2 adrenergic receptor:G-protein G(s) (active)
comment: Reviewed: Kunapuli, SP, 2010-06-07
comment: Edited: Jupe, S, 2010-06-07
comment: The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
comment: Authored: Jupe, S, 2009-05-22 08:30:21
right: G alpha (s):GTP
right: G-protein beta:gamma complex
right: ADRB2_MOUSE
right: Isoprotenerol

Mus musculus
type: BioSource
xref: UnificationXref190

Same Catalyst Activity
type: RelationshipTypeVocabulary

alpha,alpha-Trehalose
type: SmallMoleculeReference
name: alpha,alpha-Trehalose [ChEBI:10202]
name: Trehalose
name: alpha,alpha'-Trehalose
xref: UnificationXref46

UnificationXref1
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref2
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref3
type: UnificationXref
id: 29438
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 212

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 1

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref23

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 555

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 277

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 176

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 175

TREA
type: ProteinReference
name: UniProt:P19813 TREH
name: TREH
xref: UnificationXref53
comment: FUNCTION Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.CATALYTIC ACTIVITY Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.SUBUNIT Homodimer; disulfide-linked.TISSUE SPECIFICITY Small intestine, kidney, and lesser in liver.SIMILARITY Belongs to the glycosyl hydrolase 37 family.
organism: Oryctolagus cuniculus

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 41

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:P18762 Adrb2
type: ProteinReference
name: Adrb2r
name: Adrb2
xref: UnificationXref191
comment: FUNCTION Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.PTM Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
organism: Mus musculus

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 41

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 555

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 402

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 966

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 213

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

Guanosine 5'-triphosphate
type: SmallMoleculeReference
name: GTP
name: GTP [ChEBI:15996]
xref: UnificationXref2

Prostaglandin D2
type: SmallMolecule
entity reference: (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
data source: Reactome
xref: UnificationXref133
xref: UnificationXref134
cellular location: cytosol
comment: Reactome DB_ID: 879629
display name: PGD2

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref131
xref: UnificationXref130
cellular location: cytosol
comment: Reactome DB_ID: 29360
display name: NAD

PGD2/E2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: Prostaglandin E2
member physical entity: Prostaglandin F2alpha
member physical entity: Prostaglandin D2
xref: UnificationXref141
xref: UnificationXref142
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161661

alpha,alpha-trehalose
type: SmallMolecule
entity reference: alpha,alpha-Trehalose
data source: Reactome
xref: UnificationXref47
xref: UnificationXref48
cellular location: extracellular region
comment: Reactome DB_ID: 189078

alpha-D-glucose
type: SmallMolecule
entity reference: alpha-D-Glucose [ChEBI:17925]
data source: Reactome
xref: UnificationXref50
xref: UnificationXref51
cellular location: extracellular region
comment: Reactome DB_ID: 70115
display name: Glc

alpha-D-Glucose [ChEBI:17925]
type: SmallMoleculeReference
name: alpha-D-Glucose
xref: UnificationXref49

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref24
xref: UnificationXref25
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref44
xref: UnificationXref45
cellular location: extracellular region
comment: Reactome DB_ID: 109276
display name: H2O

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: Guanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref4
xref: UnificationXref3
cellular location: cytosol
comment: Reactome DB_ID: 29438
display name: GTP

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref15
xref: UnificationXref16
cellular location: cytosol
comment: Reactome DB_ID: 113592
display name: ATP

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 77

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 228

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 152

ChEBI:29152 Cys-tRNA(Cys)
type: SmallMoleculeReference
name: Cys-tRNA(Cys)
xref: UnificationXref215

UniProt:G1TBB5
type: ProteinReference
name: HPGD
xref: UnificationXref160
comment: SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
organism: Oryctolagus cuniculus

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 152

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 77

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 228

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 304

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 229

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 380

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 305

http://identifiers.org/pubmed/8736705
type: PublicationXref
id: 8736705
author: Basi, NS
author: Okuya, S
author: Rebois, RV
db: Pubmed
title: GTP binding to Gs does not promote subunit dissociation
source: Cell Signal 8:209-15
year: 1996

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref285

Arg-tRNA(Arg)
type: SmallMoleculeReference
name: ChEBI:18366 Arg-tRNA(Arg)
xref: UnificationXref206

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite61
type: SequenceSite
position status: EQUAL
sequence position: 353

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref50
type: UnificationXref
id: 70115
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70115

Ubiquitin ligase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref125
xref: UnificationXref126
cellular location: cytosol
comment: Reactome DB_ID: 69593

Val-tRNA(Val)
type: SmallMoleculeReference
name: ChEBI:29164 Val-tRNA(Val)
xref: UnificationXref260

fMet-tRNA
type: PhysicalEntity
data source: Reactome
name: methionyl initiator tRNA
name: Met-tRNAf
xref: UnificationXref272
xref: UnificationXref273
cellular location: cytosol
display name: Met-tRNAi
comment: Reactome DB_ID: 72393

Gln-tRNA(Gln) [ChEBI:29166]
type: SmallMoleculeReference
name: Gln-tRNA(Gln)
xref: UnificationXref218

80S ribosome
type: PhysicalEntity
data source: Reactome
xref: UnificationXref271
xref: UnificationXref270
cellular location: cytosol
comment: Reactome DB_ID: 159892

Guanine nucleotide-binding protein subunit gamma-2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref167
xref: UnificationXref168
cellular location: plasma membrane
comment: Reactome DB_ID: 421948

UnificationXref46
type: UnificationXref
id: CHEBI:16551
db: ChEBI

UnificationXref47
type: UnificationXref
id: 189078
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189078

UnificationXref44
type: UnificationXref
id: 109276
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276

Glutathione disulfide
type: SmallMoleculeReference
name: Oxidized glutathione [ChEBI:17858]
name: GSSG
name: Oxidized glutathione
xref: UnificationXref298

UnificationXref45
type: UnificationXref
id: REACT_3225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3225.1

UnificationXref42
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 524

UnificationXref43
type: UnificationXref
id: CHEBI:15377
db: ChEBI

UnificationXref40
type: UnificationXref
id: 211643
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211643

UnificationXref41
type: UnificationXref
id: REACT_13466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13466.1

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 608

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 609

ChEBI:16624 Leu-tRNA(Leu)
type: SmallMoleculeReference
name: Leu-tRNA(Leu)
xref: UnificationXref233

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 684

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 456

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 457

UnificationXref48
type: UnificationXref
id: REACT_9619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9619.1

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 532

UniProt:Q5U814 Small GTP binding protein CDC42
type: ProteinReference
name: Q5U814_RABIT
name: Small GTP binding protein CDC42
xref: UnificationXref69
comment: SIMILARITY Belongs to the small GTPase superfamily. Rho family.
organism: Oryctolagus cuniculus

UnificationXref49
type: UnificationXref
id: CHEBI:17925
db: ChEBI

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 533

ChEBI:29159 Trp-tRNA(Trp)
type: SmallMoleculeReference
name: Trp-tRNA(Trp)
xref: UnificationXref254

Glu-tRNA(Glu)
type: SmallMoleculeReference
name: Glu-tRNA(Glu) [ChEBI:29157]
xref: UnificationXref221

ChEBI:29158 Asp-tRNA(Asp)
type: SmallMoleculeReference
name: Asp-tRNA(Asp)
xref: UnificationXref212

His-tRNA(His)
type: SmallMoleculeReference
name: ChEBI:29155 His-tRNA(His)
xref: UnificationXref227

Gly-tRNA(Gly) [ChEBI:29156]
type: SmallMoleculeReference
name: Gly-tRNA(Gly)
xref: UnificationXref224

ChEBI:29153 Phe-tRNA(Phe)
type: SmallMoleculeReference
name: Phe-tRNA(Phe)
xref: UnificationXref242

Pro-tRNA(Pro)
type: SmallMoleculeReference
name: ChEBI:29154 Pro-tRNA(Pro)
xref: UnificationXref245

Thr-tRNA(Thr)
type: SmallMoleculeReference
name: ChEBI:29163 Thr-tRNA(Thr)
xref: UnificationXref251

UnificationXref33
type: UnificationXref
id: P42574
db: UniProt

Ser-tRNA(Ser)
type: SmallMoleculeReference
name: ChEBI:29162 Ser-tRNA(Ser)
xref: UnificationXref248

UnificationXref34
type: UnificationXref
id: 141644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141644

Tyr-tRNA(Tyr)
type: SmallMoleculeReference
name: ChEBI:29161 Tyr-tRNA(Tyr)
xref: UnificationXref257

UnificationXref35
type: UnificationXref
id: REACT_4142
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4142.2

Ile-tRNA(Ile)
type: SmallMoleculeReference
name: ChEBI:29160 Ile-tRNA(Ile)
xref: UnificationXref230

UnificationXref36
type: UnificationXref
id: 141646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141646

SERPINA8
type: ProteinReference
name: AGT
name: UniProt:P01019 AGT
xref: UnificationXref59
comment: TISSUE SPECIFICITY Expressed by the liver and secreted in plasma.PTM Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.PTM The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.SIMILARITY Belongs to the serpin family.CAUTION It is uncertain whether Met-1 or Met-10 is the initiator.
organism: Homo sapiens

UnificationXref30
type: UnificationXref
id: 213022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213022

UnificationXref31
type: UnificationXref
id: REACT_14198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14198.1

UnificationXref32
type: UnificationXref
id: 9606
db: NCBI Taxonomy

Met-tRNA(Met) [ChEBI:16635]
type: SmallMoleculeReference
name: Met-tRNA(Met)
xref: UnificationXref239

SequenceSite68
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite69
type: SequenceSite
position status: EQUAL
sequence position: 638

SequenceSite66
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite67
type: SequenceSite
position status: EQUAL
sequence position: 638

SequenceSite64
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref37
type: UnificationXref
id: REACT_3557
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3557.2

SequenceSite65
type: SequenceSite
position status: EQUAL
sequence position: 200

UnificationXref38
type: UnificationXref
id: 141647
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141647

SequenceSite62
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref39
type: UnificationXref
id: REACT_2467
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2467.2

SequenceSite63
type: SequenceSite
position status: EQUAL
sequence position: 418

UniProt:P19941 GHR
type: ProteinReference
name: GHR
xref: UnificationXref316
comment: FUNCTION The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DOMAIN The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).DOMAIN The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.PTM The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17.PTM On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.SIMILARITY Belongs to the type I cytokine receptor family. Type 1 subfamily.SIMILARITY Contains 1 fibronectin type-III domain.
organism: Oryctolagus cuniculus

UnificationXref20
type: UnificationXref
id: MOD:00046
db: MOD

UnificationXref21
type: UnificationXref
id: 213304
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213304

UnificationXref24
type: UnificationXref
id: 29370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref25
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref22
type: UnificationXref
id: REACT_14673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14673.1

UnificationXref23
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref28
type: UnificationXref
id: 211637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211637

UnificationXref29
type: UnificationXref
id: REACT_14043
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14043.1

UnificationXref26
type: UnificationXref
id: 213297
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213297

UnificationXref27
type: UnificationXref
id: REACT_13581
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13581.1

ChEBI:17732 Ala-tRNA(Ala)
type: SmallMoleculeReference
name: Ala-tRNA(Ala)
xref: UnificationXref203

UnificationXref10
type: UnificationXref
id: REACT_4917
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4917.1

ubiquitinylated lysine
type: SequenceModificationVocabulary
xref: UnificationXref122

UnificationXref11
type: UnificationXref
id: MI:0355
db: MI

UnificationXref12
type: UnificationXref
id: 159534
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159534

UnificationXref13
type: UnificationXref
id: REACT_145
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145.3

UnificationXref14
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref15
type: UnificationXref
id: 113592
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref16
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref17
type: UnificationXref
id: Q29502
db: UniProt

UnificationXref18
type: UnificationXref
id: 211648
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211648

UnificationXref19
type: UnificationXref
id: REACT_14146
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14146.1

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref81

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref143

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref52

ANG2-8
type: Protein
entity reference: SERPINA8
data source: Reactome
name: AGT(35-41)
name: ANGT_HUMAN
name: Angiotensin-(2-8)
name: Angiotensin III
xref: UnificationXref60
xref: UnificationXref61
feature: FragmentFeature8
cellular location: extracellular region
comment: Reactome DB_ID: 2022354
display name: AGT

Caspase-3 (small subunit)
type: Protein
entity reference: CASP3
data source: Reactome
xref: UnificationXref36
xref: UnificationXref37
feature: FragmentFeature6
cellular location: cytosol
comment: Reactome DB_ID: 141646
display name: CASP3(176-277)

trehalase
type: Protein
entity reference: TREA
data source: Reactome
xref: UnificationXref56
xref: UnificationXref55
feature: FragmentFeature7
feature: ModificationFeature6
cellular location: plasma membrane
comment: Reactome DB_ID: 189113

Caspase-3 (large subunit)
type: Protein
entity reference: CASP3
data source: Reactome
name: CASP3(29-175)
xref: UnificationXref34
xref: UnificationXref35
feature: FragmentFeature5
cellular location: cytosol
comment: Reactome DB_ID: 141644
display name: CASP3

Auto-phosphorylated PAK-2 (p27 regulatory fragment)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref30
xref: UnificationXref31
feature: FragmentFeature4
feature: ModificationFeature2
feature: ModificationFeature3
feature: ModificationFeature4
feature: ModificationFeature5
feature: ModificationFeature1
cellular location: cytosol
comment: Reactome DB_ID: 213022

PAK-2p34
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref28
xref: UnificationXref29
feature: FragmentFeature3
cellular location: cytosol
comment: Reactome DB_ID: 211637

partially auto-phosphorylated PAK-2 (inactive)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref21
xref: UnificationXref22
feature: FragmentFeature2
feature: ModificationFeature2
feature: ModificationFeature3
feature: ModificationFeature4
feature: ModificationFeature5
feature: ModificationFeature1
cellular location: cytosol
comment: Reactome DB_ID: 213304

PAK-2
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref18
xref: UnificationXref19
feature: FragmentFeature1
cellular location: cytosol
comment: Reactome DB_ID: 211648

reEF1A
type: Protein
entity reference: EEF1A1
data source: Reactome
xref: UnificationXref7
xref: UnificationXref8
cellular location: cytosol
comment: Reactome DB_ID: 159543

http://identifiers.org/pubmed/1978675
type: PublicationXref
id: 1978675
author: Benter, IF
author: Dick, L
author: Wilk, S
author: Ward, PE
db: Pubmed
title: Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M
source: Biochem Pharmacol 40:1725-32
year: 1990

EEF1A1
type: ProteinReference
name: EEF1A
name: EF1A
name: UniProt:P68105 EEF1A1
xref: UnificationXref6
comment: TISSUE SPECIFICITY Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.SIMILARITY Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
organism: Oryctolagus cuniculus

UniProt:P11909 GPX1
type: ProteinReference
name: GPX1
xref: UnificationXref306
comment: FUNCTION Protects the hemoglobin in erythrocytes from oxidative breakdown.CATALYTIC ACTIVITY 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.SIMILARITY Belongs to the glutathione peroxidase family.
organism: Oryctolagus cuniculus

http://identifiers.org/pubmed/17488973
type: PublicationXref
id: 17488973
author: Yang, N
author: Wang, X
author: He, K
author: Jiang, J
author: Frank, SJ
author: Thangavel, C
author: Deng, L
author: Fuchs, SY
db: Pubmed
title: Determinants of growth hormone receptor down-regulation
source: Mol Endocrinol 21:1537-51
year: 2007

http://identifiers.org/pubmed/6568109
type: PublicationXref
id: 6568109
author: Carvalho, JF
author: Carvalho, MD
author: Merrick, WC
db: Pubmed
title: Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes
source: Arch Biochem Biophys 234:603-11
year: 1984

Stoichiometry33
type: Stoichiometry
physical entity: gamma-L-Glutamyl-L-cysteinyl-glycine
stoichiometric coefficient: 2.0

Stoichiometry32
type: Stoichiometry
physical entity: Aminoacyl-tRNA
stoichiometric coefficient: 1.0

UniProt:P62987 UBA52
type: ProteinReference
name: UBCEP2
name: UBA52
xref: UnificationXref91
comment: MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the ribosomal protein L40e family.SIMILARITY Contains 1 ubiquitin-like domain.
organism: Homo sapiens

Stoichiometry34
type: Stoichiometry
physical entity: GPX1_RABIT
stoichiometric coefficient: 4.0

5-HPETE
type: SmallMoleculeReference
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate [ChEBI:2061]
name: (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
xref: UnificationXref295

15-Keto-PGF2a
type: SmallMoleculeReference
name: 15-Keto-prostaglandin F2alpha
name: 15-Keto-prostaglandin F2alpha [ChEBI:760]
name: 15-Keto-prostaglandin F2a
name: 15-Keto-PGF2alpha
xref: UnificationXref155

GNB5
type: ProteinReference
name: UniProt:Q6PNB6 GNB5
xref: UnificationXref169
comment: FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SIMILARITY Belongs to the WD repeat G protein beta family.SIMILARITY Contains 7 WD repeats.
organism: Oryctolagus cuniculus

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref129

UBA80
type: ProteinReference
name: UniProt:P62979 RPS27A
name: RPS27A
name: UBCEP1
xref: UnificationXref88
comment: MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the ribosomal protein S27Ae family.SIMILARITY Contains 1 ubiquitin-like domain.
organism: Homo sapiens

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
type: SmallMoleculeReference
name: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate [ChEBI:247]
xref: UnificationXref152

UnificationXref160
type: UnificationXref
id: G1TBB5
db: UniProt

UnificationXref167
type: UnificationXref
id: 421948
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421948

UnificationXref168
type: UnificationXref
id: REACT_24592
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24592.1

UnificationXref165
type: UnificationXref
id: 2161568
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161568

UnificationXref166
type: UnificationXref
id: REACT_150263
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150263.1

UnificationXref163
type: UnificationXref
id: 2142782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142782

UnificationXref164
type: UnificationXref
id: REACT_152255
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152255.1

UnificationXref161
type: UnificationXref
id: 2142728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142728

UnificationXref162
type: UnificationXref
id: REACT_152148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152148.1

UnificationXref169
type: UnificationXref
id: Q6PNB6
db: UniProt

CASP3
type: ProteinReference
name: CPP32
name: UniProt:P42574 CASP3
xref: UnificationXref33
comment: CATALYTIC ACTIVITY Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.ENZYME REGULATION Inhibited by isatin sulfonamides.TISSUE SPECIFICITY Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.PTM Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.PTM S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.SIMILARITY Belongs to the peptidase C14A family.
organism: Homo sapiens

UnificationXref170
type: UnificationXref
id: 421942
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421942

UnificationXref171
type: UnificationXref
id: REACT_24447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24447.1

UnificationXref176
type: UnificationXref
id: Q6X973
db: UniProt

UnificationXref177
type: UnificationXref
id: 421934
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421934

UnificationXref178
type: UnificationXref
id: REACT_24345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24345.1

UnificationXref179
type: UnificationXref
id: 2003375B
db: PRF

UnificationXref172
type: UnificationXref
id: 421945
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421945

UnificationXref173
type: UnificationXref
id: REACT_24483
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24483.1

UnificationXref174
type: UnificationXref
id: 421950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421950

UnificationXref175
type: UnificationXref
id: REACT_24420
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24420.1

RelationshipXref9
type: RelationshipXref
id: GO:0008237
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref8
type: RelationshipXref
id: 189088
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189088

UnificationXref99
type: UnificationXref
id: 939230
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939230

RelationshipXref7
type: RelationshipXref
id: GO:0004555
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref97
type: UnificationXref
id: 939213
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939213

UnificationXref98
type: UnificationXref
id: REACT_24504
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24504.2

UnificationXref95
type: UnificationXref
id: 939214
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939214

UnificationXref96
type: UnificationXref
id: REACT_24747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24747.2

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref14

UnificationXref141
type: UnificationXref
id: 2161661
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161661

RelationshipXref2
type: RelationshipXref
id: 159586
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159586

UnificationXref142
type: UnificationXref
id: REACT_150622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150622.1

RelationshipXref1
type: RelationshipXref
id: GO:0019001
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref140
type: UnificationXref
id: REACT_24606
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24606.2

UnificationXref145
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

RelationshipXref6
type: RelationshipXref
id: 114327
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114327

UnificationXref146
type: UnificationXref
id: CHEBI:15378
db: ChEBI

RelationshipXref5
type: RelationshipXref
id: GO:0004197
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref143
type: UnificationXref
id: CHEBI:16908
db: ChEBI

RelationshipXref4
type: RelationshipXref
id: 213300
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213300

UnificationXref144
type: UnificationXref
id: 73473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

RelationshipXref3
type: RelationshipXref
id: GO:0016301
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref149
type: UnificationXref
id: CHEBI:15557
db: ChEBI

UnificationXref148
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

UnificationXref147
type: UnificationXref
id: 70106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref315

Reactome
type: Provenance
comment: http://www.reactome.org

RelationshipXref19
type: RelationshipXref
id: 2161894
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161894

UnificationXref150
type: UnificationXref
id: 2142752
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142752

RelationshipXref18
type: RelationshipXref
id: GO:0004602
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref151
type: UnificationXref
id: REACT_151260
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151260.1

RelationshipXref17
type: RelationshipXref
id: 159886
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159886

UnificationXref152
type: UnificationXref
id: CHEBI:15547
db: ChEBI

RelationshipXref16
type: RelationshipXref
id: GO:0003924
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref153
type: UnificationXref
id: 2142721
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142721

RelationshipXref15
type: RelationshipXref
id: 211759
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211759

UnificationXref154
type: UnificationXref
id: REACT_151184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151184.1

Q6X973_RABIT
type: ProteinReference
name: Guanine nucleotide-binding protein Gs alpha1
name: UniProt:Q6X973 Guanine nucleotide-binding protein Gs alpha1
xref: UnificationXref176
comment: <submittedName> <fullName>Guanine nucleotide-binding protein Gs alpha1</fullName> </submittedName>
organism: Oryctolagus cuniculus

RelationshipXref14
type: RelationshipXref
id: 2161572
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161572

UnificationXref155
type: UnificationXref
id: CHEBI:28442
db: ChEBI

RelationshipXref13
type: RelationshipXref
id: GO:0016404
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref156
type: UnificationXref
id: 2142799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142799

UnificationXref157
type: UnificationXref
id: REACT_152334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152334.1

RelationshipXref12
type: RelationshipXref
id: 69594
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69594

UnificationXref159
type: UnificationXref
id: REACT_151444
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151444.1

RelationshipXref10
type: RelationshipXref
id: 2022392
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022392

UnificationXref158
type: UnificationXref
id: 2161597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161597

RelationshipXref11
type: RelationshipXref
id: GO:0004842
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref124
type: UnificationXref
id: REACT_161061
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161061.1

UnificationXref123
type: UnificationXref
id: 3095872
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3095872

UnificationXref122
type: UnificationXref
id: MOD:01148
db: MOD

UnificationXref121
type: UnificationXref
id: REACT_3316
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3316.3

UnificationXref120
type: UnificationXref
id: 113595
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113595

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMoleculeReference
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
name: GSH
name: Glutathione [ChEBI:16856]
xref: UnificationXref292

UnificationXref76
type: UnificationXref
id: 213303
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213303

UnificationXref75
type: UnificationXref
id: REACT_13912
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13912.1

UnificationXref74
type: UnificationXref
id: 213298
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213298

UnificationXref73
type: UnificationXref
id: REACT_14677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14677.1

UnificationXref79
type: UnificationXref
id: 266144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266144

ChEBI:16047 Lys-tRNA(Lys)
type: SmallMoleculeReference
name: Lys-tRNA(Lys)
xref: UnificationXref236

UnificationXref78
type: UnificationXref
id: MOD:00047
db: MOD

UnificationXref77
type: UnificationXref
id: REACT_13445
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13445.1

guanine nucleotide-binding protein Gs alpha2
type: ProteinReference
name: PRF:2003375B guanine nucleotide-binding protein Gs alpha2
xref: UnificationXref179
organism: Oryctolagus cuniculus

UnificationXref82
type: UnificationXref
id: 266149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266149

UnificationXref83
type: UnificationXref
id: REACT_14500
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14500.1

UnificationXref80
type: UnificationXref
id: REACT_14232
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14232.1

UnificationXref81
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref129
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref127
type: UnificationXref
id: 212920
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212920

UnificationXref128
type: UnificationXref
id: REACT_13487
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13487.2

UnificationXref125
type: UnificationXref
id: 69593
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69593

UnificationXref126
type: UnificationXref
id: REACT_4282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4282.1

UnificationXref133
type: UnificationXref
id: 879629
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879629

UnificationXref132
type: UnificationXref
id: CHEBI:15555
db: ChEBI

UnificationXref135
type: UnificationXref
id: CHEBI:15551
db: ChEBI

UnificationXref134
type: UnificationXref
id: REACT_24396
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24396.2

UnificationXref131
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

UnificationXref130
type: UnificationXref
id: 29360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

UnificationXref320
type: UnificationXref
id: REACT_111364
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111364.1

UnificationXref85
type: UnificationXref
id: REACT_13654
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13654.1

http://identifiers.org/pubmed/3141418
type: PublicationXref
id: 3141418
author: RansnÃ¤s, LA
author: Insel, PA
db: Pubmed
title: Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes
source: J Biol Chem 263:17239-42
year: 1988

UnificationXref84
type: UnificationXref
id: 266151
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266151

UnificationXref322
type: UnificationXref
id: REACT_111154
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111154.1

UnificationXref87
type: UnificationXref
id: REACT_14018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14018.1

UnificationXref321
type: UnificationXref
id: 1169264
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169264

UnificationXref86
type: UnificationXref
id: 211641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211641

UnificationXref89
type: UnificationXref
id: 939205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939205

UnificationXref88
type: UnificationXref
id: P62979
db: UniProt

UnificationXref90
type: UnificationXref
id: REACT_24666
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24666.2

UnificationXref91
type: UnificationXref
id: P62987
db: UniProt

ANPEP
type: ProteinReference
name: UniProt:P15541 ANPEP
xref: UnificationXref64
comment: CATALYTIC ACTIVITY Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.SIMILARITY Belongs to the peptidase M1 family.
organism: Oryctolagus cuniculus

UnificationXref92
type: UnificationXref
id: 939203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939203

UnificationXref93
type: UnificationXref
id: REACT_24649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24649.2

UnificationXref94
type: UnificationXref
id: P0CG47
db: UniProt

UnificationXref136
type: UnificationXref
id: 265287
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287

UnificationXref137
type: UnificationXref
id: REACT_15804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15804.2

UnificationXref138
type: UnificationXref
id: CHEBI:15553
db: ChEBI

UnificationXref139
type: UnificationXref
id: 879535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535

UnificationXref212
type: UnificationXref
id: CHEBI:29158
db: ChEBI

UnificationXref211
type: UnificationXref
id: REACT_15840
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15840.1

UnificationXref210
type: UnificationXref
id: 379728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379728

UnificationXref102
type: UnificationXref
id: 939188
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939188

UnificationXref101
type: UnificationXref
id: P0CG48
db: UniProt

messenger RNA [ChEBI:33699]
type: SmallMoleculeReference
name: messenger RNA
name: template RNA
name: mRNA
xref: UnificationXref267

UnificationXref100
type: UnificationXref
id: REACT_24537
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24537.2

UnificationXref59
type: UnificationXref
id: P01019
db: UniProt

UnificationXref58
type: UnificationXref
id: REACT_9495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9495.2

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref42

UnificationXref57
type: UnificationXref
id: 189019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189019

UnificationXref56
type: UnificationXref
id: REACT_9589
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9589.1

UnificationXref55
type: UnificationXref
id: 189113
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189113

UnificationXref311
type: UnificationXref
id: 2161896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161896

UnificationXref54
type: UnificationXref
id: MOD:00171
db: MOD

UnificationXref310
type: UnificationXref
id: REACT_151975
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151975.1

UnificationXref53
type: UnificationXref
id: P19813
db: UniProt

UnificationXref52
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref51
type: UnificationXref
id: REACT_4078
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4078.3

UnificationXref314
type: UnificationXref
id: REACT_755
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_755.3

UnificationXref60
type: UnificationXref
id: 2022354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022354

UnificationXref315
type: UnificationXref
id: GO:0031904
db: GENE ONTOLOGY

UnificationXref61
type: UnificationXref
id: REACT_148101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148101.2

UnificationXref312
type: UnificationXref
id: REACT_150379
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150379.1

UnificationXref313
type: UnificationXref
id: 159540
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159540

UnificationXref318
type: UnificationXref
id: REACT_111331
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111331.1

UnificationXref319
type: UnificationXref
id: 1169260
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169260

UnificationXref316
type: UnificationXref
id: P19941
db: UniProt

UnificationXref317
type: UnificationXref
id: 1169266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169266

UnificationXref219
type: UnificationXref
id: 379772
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379772

UnificationXref105
type: UnificationXref
id: REACT_24312
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24312.2

UnificationXref106
type: UnificationXref
id: 939258
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939258

UnificationXref217
type: UnificationXref
id: REACT_15780
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15780.1

UnificationXref103
type: UnificationXref
id: REACT_24844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24844.2

UnificationXref218
type: UnificationXref
id: CHEBI:29166
db: ChEBI

UnificationXref104
type: UnificationXref
id: 939164
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939164

http://identifiers.org/pubmed/12853446
type: PublicationXref
id: 12853446
author: McCarthy, CC
author: Stringer, DK
author: Koeppel, MA
author: Jakobi, R
db: Pubmed
title: Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
source: J Biol Chem 278:38675-85
year: 2003

http://identifiers.org/pubmed/19754430
type: PublicationXref
id: 19754430
author: Komander, David
db: Pubmed
title: The emerging complexity of protein ubiquitination
source: Biochem. Soc. Trans. 37:937-53
year: 2009

UnificationXref215
type: UnificationXref
id: CHEBI:29152
db: ChEBI

UnificationXref109
type: UnificationXref
id: REACT_24880
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24880.2

UnificationXref216
type: UnificationXref
id: 379719
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379719

UnificationXref213
type: UnificationXref
id: 379707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379707

UnificationXref107
type: UnificationXref
id: REACT_24765
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24765.2

UnificationXref214
type: UnificationXref
id: REACT_15677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15677.1

UnificationXref108
type: UnificationXref
id: 939192
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939192

UnificationXref201
type: UnificationXref
id: 211638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211638

UnificationXref200
type: UnificationXref
id: REACT_24008
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24008.2

UnificationXref111
type: UnificationXref
id: REACT_24675
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24675.2

UnificationXref110
type: UnificationXref
id: 939232
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939232

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref209

UnificationXref113
type: UnificationXref
id: REACT_24153
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24153.2

UnificationXref112
type: UnificationXref
id: 939191
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939191

UnificationXref67
type: UnificationXref
id: 2022369
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022369

UnificationXref66
type: UnificationXref
id: REACT_148322
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148322.1

UnificationXref69
type: UnificationXref
id: Q5U814
db: UniProt

UnificationXref68
type: UnificationXref
id: REACT_147750
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147750.3

UnificationXref63
type: UnificationXref
id: REACT_148235
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148235.2

UnificationXref62
type: UnificationXref
id: 2022355
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022355

UnificationXref300
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref65
type: UnificationXref
id: 2022347
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022347

UnificationXref64
type: UnificationXref
id: P15541
db: UniProt

UnificationXref301
type: UnificationXref
id: CHEBI:28209
db: ChEBI

UnificationXref302
type: UnificationXref
id: 2142733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142733

UnificationXref70
type: UnificationXref
id: 213296
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213296

UnificationXref303
type: UnificationXref
id: REACT_151106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151106.1

UnificationXref71
type: UnificationXref
id: REACT_14320
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14320.1

UnificationXref304
type: UnificationXref
id: 29356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

UnificationXref72
type: UnificationXref
id: 213299
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213299

UnificationXref305
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

UnificationXref306
type: UnificationXref
id: P11909
db: UniProt

UnificationXref307
type: UnificationXref
id: 2142684
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142684

UnificationXref308
type: UnificationXref
id: REACT_151039
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151039.1

UnificationXref309
type: UnificationXref
id: 2142680
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142680

UnificationXref206
type: UnificationXref
id: CHEBI:18366
db: ChEBI

UnificationXref114
type: UnificationXref
id: 939184
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939184

UnificationXref207
type: UnificationXref
id: 379720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379720

UnificationXref115
type: UnificationXref
id: REACT_24496
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24496.2

UnificationXref208
type: UnificationXref
id: REACT_15727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15727.1

UnificationXref116
type: UnificationXref
id: 939239
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939239

UnificationXref209
type: UnificationXref
id: CHEBI:29265
db: ChEBI

UnificationXref117
type: UnificationXref
id: REACT_24411
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24411.2

UnificationXref202
type: UnificationXref
id: REACT_13817
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13817.1

UnificationXref118
type: UnificationXref
id: 939165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939165

UnificationXref203
type: UnificationXref
id: CHEBI:17732
db: ChEBI

UnificationXref119
type: UnificationXref
id: REACT_24885
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24885.2

UnificationXref204
type: UnificationXref
id: 379700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379700

UnificationXref205
type: UnificationXref
id: REACT_17687
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17687.1

UnificationXref236
type: UnificationXref
id: CHEBI:16047
db: ChEBI

UnificationXref235
type: UnificationXref
id: REACT_17915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17915.1

UnificationXref238
type: UnificationXref
id: REACT_15620
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15620.1

UnificationXref237
type: UnificationXref
id: 379736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379736

UnificationXref239
type: UnificationXref
id: CHEBI:16635
db: ChEBI

glutathione disulfide
type: SmallMolecule
entity reference: Glutathione disulfide
data source: Reactome
name: oxidized glutathione
xref: UnificationXref299
xref: UnificationXref300
cellular location: cytosol
comment: Reactome DB_ID: 111745
display name: GSSG

(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
type: SmallMolecule
entity reference: 5-HPETE
data source: Reactome
xref: UnificationXref297
xref: UnificationXref296
cellular location: cytosol
comment: Reactome DB_ID: 266010
display name: 5S-HpETE

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMolecule
entity reference: gamma-L-Glutamyl-L-cysteinyl-glycine
data source: Reactome
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
xref: UnificationXref294
xref: UnificationXref293
cellular location: cytosol
comment: Reactome DB_ID: 29450
display name: GSH

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref287
xref: UnificationXref286
cellular location: cytosol
comment: Reactome DB_ID: 29372
display name: Pi

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref304
xref: UnificationXref305
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

5S-HETE
type: SmallMolecule
entity reference: 5-HETE
data source: Reactome
xref: UnificationXref302
xref: UnificationXref303
cellular location: cytosol
comment: Reactome DB_ID: 2142733

messenger RNA
type: SmallMolecule
entity reference: messenger RNA [ChEBI:33699]
data source: Reactome
xref: UnificationXref268
xref: UnificationXref269
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 162612
display name: mRNA

Oryctolagus cuniculus
type: BioSource
xref: UnificationXref5

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: Guanosine 5'-diphosphate
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref279
xref: UnificationXref280
cellular location: cytosol
comment: Reactome DB_ID: 29420
display name: GDP

Val-tRNA(Val)
type: SmallMolecule
entity reference: Val-tRNA(Val)
data source: Reactome
xref: UnificationXref262
xref: UnificationXref261
cellular location: cytosol
comment: Reactome DB_ID: 379790

UnificationXref230
type: UnificationXref
id: CHEBI:29160
db: ChEBI

UnificationXref231
type: UnificationXref
id: 379787
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379787

UnificationXref232
type: UnificationXref
id: REACT_17273
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17273.1

UnificationXref233
type: UnificationXref
id: CHEBI:16624
db: ChEBI

UnificationXref234
type: UnificationXref
id: 379757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379757

UnificationXref227
type: UnificationXref
id: CHEBI:29155
db: ChEBI

UnificationXref226
type: UnificationXref
id: REACT_18164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18164.1

UnificationXref225
type: UnificationXref
id: 379784
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379784

UnificationXref224
type: UnificationXref
id: CHEBI:29156
db: ChEBI

http://identifiers.org/pubmed/6466686
type: PublicationXref
id: 6466686
author: Galand, G
db: Pubmed
title: Purification and characterization of kidney and intestinal brush-border membrane trehalases from the rabbit
source: Biochim Biophys Acta 789:10-9
year: 1984

UnificationXref229
type: UnificationXref
id: REACT_17784
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17784.1

UnificationXref228
type: UnificationXref
id: 379786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379786

Met-tRNA(Met)
type: SmallMolecule
entity reference: Met-tRNA(Met) [ChEBI:16635]
data source: Reactome
xref: UnificationXref240
xref: UnificationXref241
cellular location: cytosol
comment: Reactome DB_ID: 379794

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: ChEBI:16047 Lys-tRNA(Lys)
data source: Reactome
xref: UnificationXref238
xref: UnificationXref237
cellular location: cytosol
comment: Reactome DB_ID: 379736

UBC
type: ProteinReference
name: UniProt:P0CG48 UBC
xref: UnificationXref101
comment: MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.SIMILARITY Contains 9 ubiquitin-like domains.
organism: Homo sapiens

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: Pro-tRNA(Pro)
data source: Reactome
xref: UnificationXref247
xref: UnificationXref246
cellular location: cytosol
comment: Reactome DB_ID: 379746

UniProt:P0CG47 UBB
type: ProteinReference
name: UBB
xref: UnificationXref94
comment: MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GT dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in Alzheimer disease and other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant cannot be used for polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and ubiquitinated UBB(+1) is refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1) C-terminus can be cleaved by UCHL3 (PubMed:21762696).MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY Belongs to the ubiquitin family.SIMILARITY Contains 3 ubiquitin-like domains.
organism: Homo sapiens

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: ChEBI:29153 Phe-tRNA(Phe)
data source: Reactome
xref: UnificationXref244
xref: UnificationXref243
cellular location: cytosol
comment: Reactome DB_ID: 379792

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: Thr-tRNA(Thr)
data source: Reactome
xref: UnificationXref253
xref: UnificationXref252
cellular location: cytosol
comment: Reactome DB_ID: 379783

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: Ser-tRNA(Ser)
data source: Reactome
xref: UnificationXref249
xref: UnificationXref250
cellular location: cytosol
comment: Reactome DB_ID: 379738

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: Tyr-tRNA(Tyr)
data source: Reactome
xref: UnificationXref258
xref: UnificationXref259
cellular location: cytosol
comment: Reactome DB_ID: 379785

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: ChEBI:29159 Trp-tRNA(Trp)
data source: Reactome
xref: UnificationXref255
xref: UnificationXref256
cellular location: cytosol
comment: Reactome DB_ID: 379765

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref146

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: Ile-tRNA(Ile)
data source: Reactome
xref: UnificationXref231
xref: UnificationXref232
cellular location: cytosol
comment: Reactome DB_ID: 379787

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: ChEBI:16624 Leu-tRNA(Leu)
data source: Reactome
xref: UnificationXref235
xref: UnificationXref234
cellular location: cytosol
comment: Reactome DB_ID: 379757

UnificationXref222
type: UnificationXref
id: 379751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379751

active caspase-3
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry6
component stoichiometry: Stoichiometry5
component: Caspase-3 (large subunit)
component: Caspase-3 (small subunit)
xref: UnificationXref38
xref: UnificationXref39
cellular location: cytosol
comment: Reactome DB_ID: 141647

UnificationXref223
type: UnificationXref
id: REACT_16052
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16052.1

CDC42-GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry8
component stoichiometry: Stoichiometry9
component: Cdc42
component: Guanosine 5'-triphosphate
xref: UnificationXref72
xref: UnificationXref73
cellular location: cytosol
comment: Reactome DB_ID: 213299

UnificationXref220
type: UnificationXref
id: REACT_15566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15566.1

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref43

UnificationXref221
type: UnificationXref
id: CHEBI:29157
db: ChEBI

reEF1A:GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component stoichiometry: Stoichiometry1
component: reEF1A
component: Guanosine 5'-triphosphate
xref: UnificationXref10
xref: UnificationXref9
cellular location: cytosol
comment: Reactome DB_ID: 159530

G alpha (s):GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry16
component stoichiometry: Stoichiometry17
component: Guanosine 5'-triphosphate
component: G(s) alpha subunit
xref: UnificationXref187
xref: UnificationXref186
cellular location: plasma membrane
comment: Reactome DB_ID: 421955

G-protein beta:gamma complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry13
component stoichiometry: Stoichiometry14
component: G-protein beta subunit
component: Guanine nucleotide-binding protein subunit gamma-2
xref: UnificationXref174
xref: UnificationXref175
cellular location: plasma membrane
comment: Reactome DB_ID: 421950

http://identifiers.org/pubmed/9786869
type: PublicationXref
id: 9786869
author: Traugh, JA
author: Huang, Z
author: Walter, BN
author: Tuazon, PT
author: Litwack, G
author: Alnemri, ES
author: Jakobi, R
db: Pubmed
title: Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
source: J Biol Chem 273:28733-9
year: 1998

UnificationXref258
type: UnificationXref
id: 379785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379785

HPGD dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry12
component: G1TBB5_RABIT
xref: UnificationXref163
xref: UnificationXref164
cellular location: cytosol
comment: Reactome DB_ID: 2142782

UnificationXref257
type: UnificationXref
id: CHEBI:29161
db: ChEBI

Inactive Pak2:Cdc42-GTP complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry10
component stoichiometry: Stoichiometry11
component: partially auto-phosphorylated PAK-2 (inactive)
component: CDC42-GTP
xref: UnificationXref75
xref: UnificationXref74
cellular location: cytosol
comment: Reactome DB_ID: 213298

Heterotrimeric G-protein Gs (active)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry18
component stoichiometry: Stoichiometry15
component: G alpha (s):GTP
component: G-protein beta:gamma complex
xref: UnificationXref188
xref: UnificationXref189
cellular location: plasma membrane
comment: Reactome DB_ID: 421958

UnificationXref259
type: UnificationXref
id: REACT_18116
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18116.1

Isoprotenerol:beta-2 adrenergic receptor:G-protein G(s) (active)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry19
component stoichiometry: Stoichiometry20
component stoichiometry: Stoichiometry21
component: Heterotrimeric G-protein Gs (active)
component: ADRB2_MOUSE
component: Isoprotenerol
xref: UnificationXref198
xref: UnificationXref197
cellular location: plasma membrane
comment: Reactome DB_ID: 421959

UnificationXref253
type: UnificationXref
id: REACT_17415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17415.1

UnificationXref254
type: UnificationXref
id: CHEBI:29159
db: ChEBI

UnificationXref255
type: UnificationXref
id: 379765
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379765

UnificationXref256
type: UnificationXref
id: REACT_17447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17447.1

UnificationXref250
type: UnificationXref
id: REACT_17419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17419.1

UnificationXref251
type: UnificationXref
id: CHEBI:29163
db: ChEBI

UnificationXref252
type: UnificationXref
id: 379783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379783

http://identifiers.org/pubmed/1697585
type: PublicationXref
id: 1697585
author: Wacker, H
author: Galand, G
author: Mantei, N
author: Ruf, J
author: von Kieckebusch, A
author: James, P
author: Maffia, M
author: Seiler, P
author: Semenza, G
db: Pubmed
title: Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.
source: J Biol Chem 265:15034-9
year: 1990

UnificationXref249
type: UnificationXref
id: 379738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379738

UnificationXref248
type: UnificationXref
id: CHEBI:29162
db: ChEBI

UnificationXref247
type: UnificationXref
id: REACT_17288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17288.1

UnificationXref246
type: UnificationXref
id: 379746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379746

http://identifiers.org/pubmed/9427547
type: PublicationXref
id: 9427547
author: Taketani, S
author: Tokunaga, R
author: Kino, M
author: Kobayashi, Y
author: Ishihara, R
author: Sasai-Takedatsu, M
db: Pubmed
title: Molecular cloning, sequencing and expression of cDNA encoding human trehalase
source: Gene 202:69-74
year: 1997

UnificationXref244
type: UnificationXref
id: REACT_15573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15573.1

UnificationXref245
type: UnificationXref
id: CHEBI:29154
db: ChEBI

N-seryl-glycosylphosphatidylinositolethanolamine
type: SequenceModificationVocabulary
xref: UnificationXref54

UnificationXref242
type: UnificationXref
id: CHEBI:29153
db: ChEBI

UnificationXref243
type: UnificationXref
id: 379792
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379792

UnificationXref240
type: UnificationXref
id: 379794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379794

UnificationXref241
type: UnificationXref
id: REACT_18004
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18004.1

PAK2
type: ProteinReference
name: UniProt:Q29502 PAK2
xref: UnificationXref17
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.SIMILARITY Contains 1 CRIB domain.SIMILARITY Contains 1 protein kinase domain.
organism: Oryctolagus cuniculus

UnificationXref279
type: UnificationXref
id: 29420
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

Catalysis10
type: Catalysis
data source: Reactome
controlled: 5S-HpETE is reduced to 5S-HETE by GPX1
control type: ACTIVATION
xref: RelationshipXref19
xref: RelationshipXref18
controller: glutathione peroxidase tetramer

UnificationXref272
type: UnificationXref
id: 72393
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72393

UnificationXref271
type: UnificationXref
id: REACT_4521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4521.1

UnificationXref274
type: UnificationXref
id: 159893
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159893

UnificationXref273
type: UnificationXref
id: REACT_4829
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4829.1

UnificationXref276
type: UnificationXref
id: 159883
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159883

UnificationXref275
type: UnificationXref
id: REACT_2946
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2946.1

UnificationXref278
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref277
type: UnificationXref
id: REACT_5056
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5056.1

UnificationXref270
type: UnificationXref
id: 159892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159892

Catalysis6
type: Catalysis
data source: Reactome
controlled: Ubiquitination of PAK-2p34
control type: ACTIVATION
xref: RelationshipXref11
xref: RelationshipXref12
controller: Ubiquitin ligase

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref11

Catalysis5
type: Catalysis
data source: Reactome
controlled: ANPEP hydrolyzes Angiotensin III to Angiotensin IV
control type: ACTIVATION
xref: RelationshipXref10
xref: RelationshipXref9
controller: AMPN_RABIT

Catalysis8
type: Catalysis
data source: Reactome
controlled: Autophosphorylation of PAK-2p34
control type: ACTIVATION
xref: RelationshipXref15
xref: RelationshipXref3
controller: PAK-2p34

Catalysis7
type: Catalysis
data source: Reactome
controlled: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
control type: ACTIVATION
xref: RelationshipXref14
xref: RelationshipXref13
controller: HPGD dimer

Catalysis2
type: Catalysis
data source: Reactome
controlled: Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: PAK-2

Catalysis1
type: Catalysis
data source: Reactome
controlled: reEF1A complexes with GTP
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: reEF1A

Catalysis4
type: Catalysis
data source: Reactome
controlled: Digestion of trehalose to yield glucose
control type: ACTIVATION
xref: RelationshipXref8
xref: RelationshipXref7
controller: trehalase

Catalysis3
type: Catalysis
data source: Reactome
controlled: Cleavage of PAK-2 at 212
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref5
controller: active caspase-3

UnificationXref268
type: UnificationXref
id: 162612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162612

UnificationXref269
type: UnificationXref
id: REACT_3563
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3563.1

UnificationXref263
type: UnificationXref
id: 37001
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=37001

Homo sapiens
type: BioSource
xref: UnificationXref32

UnificationXref262
type: UnificationXref
id: REACT_15717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15717.1

UnificationXref261
type: UnificationXref
id: 379790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379790

UnificationXref260
type: UnificationXref
id: CHEBI:29164
db: ChEBI

UnificationXref267
type: UnificationXref
id: CHEBI:33699
db: ChEBI

UnificationXref266
type: UnificationXref
id: REACT_4375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4375.1

ISUPREL (TN)
type: SmallMoleculeReference
name: Isoproterenol
name: Isoproterenol [ChEBI:6046]
xref: UnificationXref194

UnificationXref265
type: UnificationXref
id: 159538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159538

UnificationXref264
type: UnificationXref
id: REACT_4792
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4792.1

O-phospho-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref20

O-phospho-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref78

Catalysis9
type: Catalysis
data source: Reactome
controlled: Hydrolysis of reEF1A:GTP
control type: ACTIVATION
xref: RelationshipXref17
xref: RelationshipXref16
controller: 80S ribosome

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: Glu-tRNA(Glu)
data source: Reactome
xref: UnificationXref222
xref: UnificationXref223
cellular location: cytosol
comment: Reactome DB_ID: 379751

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 20

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: Gly-tRNA(Gly) [ChEBI:29156]
data source: Reactome
xref: UnificationXref226
xref: UnificationXref225
cellular location: cytosol
comment: Reactome DB_ID: 379784

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 55

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: ChEBI:29152 Cys-tRNA(Cys)
data source: Reactome
xref: UnificationXref217
xref: UnificationXref216
cellular location: cytosol
comment: Reactome DB_ID: 379719

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 192

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: Gln-tRNA(Gln) [ChEBI:29166]
data source: Reactome
xref: UnificationXref219
xref: UnificationXref220
cellular location: cytosol
comment: Reactome DB_ID: 379772

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 197

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: ChEBI:29265 Asn-tRNA(Asn)
data source: Reactome
xref: UnificationXref211
xref: UnificationXref210
cellular location: cytosol
comment: Reactome DB_ID: 379728

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 1

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: ChEBI:29158 Asp-tRNA(Asp)
data source: Reactome
xref: UnificationXref213
xref: UnificationXref214
cellular location: cytosol
comment: Reactome DB_ID: 379707

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 524

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: ChEBI:17732 Ala-tRNA(Ala)
data source: Reactome
xref: UnificationXref204
xref: UnificationXref205
cellular location: cytosol
comment: Reactome DB_ID: 379700

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: Arg-tRNA(Arg)
data source: Reactome
xref: UnificationXref207
xref: UnificationXref208
cellular location: cytosol
comment: Reactome DB_ID: 379720

Growth hormone receptor
type: Protein
entity reference: UniProt:P19941 GHR
data source: Reactome
xref: UnificationXref319
xref: UnificationXref320
feature: FragmentFeature31
cellular location: plasma membrane
comment: Reactome DB_ID: 1169260
display name: GHR

Growth hormone receptor
type: Protein
entity reference: UniProt:P19941 GHR
data source: Reactome
xref: UnificationXref318
xref: UnificationXref317
feature: FragmentFeature30
cellular location: endosome lumen
comment: Reactome DB_ID: 1169266
display name: GHR

His-tRNA(His)
type: SmallMolecule
entity reference: His-tRNA(His)
data source: Reactome
xref: UnificationXref229
xref: UnificationXref228
cellular location: cytosol
comment: Reactome DB_ID: 379786

UnificationXref298
type: UnificationXref
id: CHEBI:17858
db: ChEBI

UnificationXref297
type: UnificationXref
id: REACT_15596
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15596.2

http://identifiers.org/pubmed/16204230
type: PublicationXref
id: 16204230
author: Traugh, JA
author: Jung, JH
db: Pubmed
title: Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
source: J Biol Chem 280:40025-31
year: 2005

UnificationXref299
type: UnificationXref
id: 111745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref294
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

UnificationXref293
type: UnificationXref
id: 29450
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

UnificationXref296
type: UnificationXref
id: 266010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010

UnificationXref295
type: UnificationXref
id: CHEBI:15632
db: ChEBI

UnificationXref290
type: UnificationXref
id: 159620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159620

Aminoacyl-tRNA
type: SmallMolecule
data source: Reactome
member physical entity: Glu-tRNA(Glu)
member physical entity: Gly-tRNA(Gly)
member physical entity: Cys-tRNA(Cys)
member physical entity: Gln-tRNA(Gln)
member physical entity: Asn-tRNA(Asn)
member physical entity: Asp-tRNA(Asp)
member physical entity: Ala-tRNA(Ala)
member physical entity: Arg-tRNA(Arg)
member physical entity: Met-tRNA(Met)
member physical entity: Lys-tRNA(Lys)
member physical entity: Pro-tRNA(Pro)
member physical entity: Phe-tRNA(Phe)
member physical entity: Thr-tRNA(Thr)
member physical entity: Ser-tRNA(Ser)
member physical entity: Tyr-tRNA(Tyr)
member physical entity: His-tRNA(His)
member physical entity: Trp-tRNA(Trp)
member physical entity: Ile-tRNA(Ile)
member physical entity: Val-tRNA(Val)
member physical entity: Leu-tRNA(Leu)
xref: UnificationXref263
xref: UnificationXref264
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 37001

UnificationXref292
type: UnificationXref
id: CHEBI:16856
db: ChEBI

UnificationXref291
type: UnificationXref
id: REACT_1353
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1353.3

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 524

15k-PGD2/E2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: 15k-PGD2
member physical entity: 15k-PGE2
member physical entity: 15k-PGF2a
xref: UnificationXref159
xref: UnificationXref158
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161597

15k-PGD2
type: SmallMolecule
entity reference: (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate [ChEBI:249]
data source: Reactome
xref: UnificationXref150
xref: UnificationXref151
cellular location: cytosol
comment: Reactome DB_ID: 2142752

15k-PGE2
type: SmallMolecule
entity reference: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
data source: Reactome
xref: UnificationXref153
xref: UnificationXref154
cellular location: cytosol
comment: Reactome DB_ID: 2142721

80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry28
component: reEF1A:GTP:Aminoacyl-tRNA complex
component: 80S:Met-tRNAi:mRNA
xref: UnificationXref276
xref: UnificationXref277
cellular location: cytosol
comment: Reactome DB_ID: 159883

15k-PGF2a
type: SmallMolecule
entity reference: 15-Keto-PGF2a
data source: Reactome
xref: UnificationXref156
xref: UnificationXref157
cellular location: cytosol
comment: Reactome DB_ID: 2142799

reEF1A:GTP:Aminoacyl-tRNA complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry23
component: Aminoacyl-tRNA
component: reEF1A:GTP
xref: UnificationXref266
xref: UnificationXref265
cellular location: cytosol
comment: Reactome DB_ID: 159538

Prostaglandin E2
type: SmallMolecule
entity reference: Prostaglandin E2 [ChEBI:8512]
data source: Reactome
xref: UnificationXref136
xref: UnificationXref137
cellular location: cytosol
comment: Reactome DB_ID: 265287
display name: PGE2

80S:Met-tRNAi:mRNA
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry25
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry27
component: messenger RNA
component: fMet-tRNA
component: 80S ribosome
xref: UnificationXref274
xref: UnificationXref275
cellular location: cytosol
comment: Reactome DB_ID: 159893

Prostaglandin F2alpha
type: SmallMolecule
entity reference: Prostaglandin F2a
data source: Reactome
xref: UnificationXref140
xref: UnificationXref139
cellular location: cytosol
comment: Reactome DB_ID: 879535
display name: PGF2a

reEF1A:GDP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry29
component stoichiometry: Stoichiometry30
component: Guanosine 5'-diphosphate
component: reEF1A
xref: UnificationXref282
xref: UnificationXref281
cellular location: cytosol
comment: Reactome DB_ID: 159625

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref145
xref: UnificationXref144
cellular location: cytosol
comment: Reactome DB_ID: 73473

80S:Met-tRNAi:mRNA:aa-tRNA
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry32
component stoichiometry: Stoichiometry31
component: 80S:Met-tRNAi:mRNA
component: Aminoacyl-tRNA
xref: UnificationXref284
xref: UnificationXref283
cellular location: cytosol
comment: Reactome DB_ID: 159890

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref148
xref: UnificationXref147
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

glutathione peroxidase tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry34
component: GPX1_RABIT
xref: UnificationXref309
xref: UnificationXref310
cellular location: cytosol
display name: GPX1 tetramer
comment: Reactome DB_ID: 2142680

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: Guanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref184
xref: UnificationXref185
cellular location: plasma membrane
comment: Reactome DB_ID: 113572
display name: GTP

Isoprotenerol
type: SmallMolecule
entity reference: ISUPREL (TN)
data source: Reactome
xref: UnificationXref196
xref: UnificationXref195
cellular location: extracellular region
comment: Reactome DB_ID: 421954
display name: ISPOL

UnificationXref289
type: UnificationXref
id: REACT_712
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_712.3

UnificationXref288
type: UnificationXref
id: 159603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159603

UnificationXref287
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

UnificationXref286
type: UnificationXref
id: 29372
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

UnificationXref285
type: UnificationXref
id: CHEBI:18367
db: ChEBI

UnificationXref284
type: UnificationXref
id: REACT_5893
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5893.1

UnificationXref283
type: UnificationXref
id: 159890
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159890

UnificationXref282
type: UnificationXref
id: REACT_3552
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3552.1

UnificationXref281
type: UnificationXref
id: 159625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159625

UnificationXref280
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1