UnificationXref656
type: UnificationXref
id: CHEBI:15857
db: ChEBI

UnificationXref657
type: UnificationXref
id: 1222422
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222422

UnificationXref654
type: UnificationXref
id: 2103117
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2103117

UnificationXref655
type: UnificationXref
id: REACT_122542
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122542.1

UnificationXref658
type: UnificationXref
id: REACT_124129
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124129.1

UnificationXref659
type: UnificationXref
id: CHEBI:61088
db: ChEBI

UnificationXref652
type: UnificationXref
id: 2103119
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2103119

UnificationXref653
type: UnificationXref
id: REACT_122468
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122468.1

UnificationXref650
type: UnificationXref
id: GO:0042597
db: GENE ONTOLOGY

UnificationXref651
type: UnificationXref
id: CHEBI:50091
db: ChEBI

UnificationXref216
type: UnificationXref
id: REACT_27236
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27236.1

UnificationXref217
type: UnificationXref
id: CHEBI:15444
db: ChEBI

UnificationXref214
type: UnificationXref
id: REACT_27346
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27346.1

UnificationXref215
type: UnificationXref
id: 868709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868709

UnificationXref218
type: UnificationXref
id: 868686
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868686

UnificationXref219
type: UnificationXref
id: REACT_27389
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27389.1

UnificationXref212
type: UnificationXref
id: P9WQ19
db: UniProt

UnificationXref213
type: UnificationXref
id: 868682
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868682

http://identifiers.org/pubmed/11959913
type: PublicationXref
id: 11959913
author: Richard, C
author: Wittenberg, B
author: Labarre, M
author: Wittenberg, J
author: Ouellet, Y
author: Ouellet, H
author: Guertin, M
db: Pubmed
title: Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide
source: Proc Natl Acad Sci U S A 99:5902-7
year: 2002

UnificationXref210
type: UnificationXref
id: 868706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868706

UnificationXref211
type: UnificationXref
id: REACT_27645
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27645.2

UnificationXref665
type: UnificationXref
id: 1222712
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222712

UnificationXref666
type: UnificationXref
id: REACT_120883
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120883.3

UnificationXref667
type: UnificationXref
id: 1222538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222538

UnificationXref668
type: UnificationXref
id: REACT_120983
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120983.3

UnificationXref669
type: UnificationXref
id: P9WGE7
db: UniProt

UnificationXref660
type: UnificationXref
id: 1222680
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222680

UnificationXref661
type: UnificationXref
id: REACT_124699
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124699.1

UnificationXref662
type: UnificationXref
id: P71828
db: UniProt

UnificationXref663
type: UnificationXref
id: 1222419
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222419

UnificationXref664
type: UnificationXref
id: REACT_124045
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124045.1

UnificationXref225
type: UnificationXref
id: 868658
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868658

UnificationXref226
type: UnificationXref
id: REACT_27294
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27294.1

UnificationXref227
type: UnificationXref
id: 868632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868632

UnificationXref228
type: UnificationXref
id: REACT_27344
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27344.1

UnificationXref229
type: UnificationXref
id: P9WQ23
db: UniProt

UnificationXref220
type: UnificationXref
id: 868613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868613

UnificationXref221
type: UnificationXref
id: REACT_27718
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27718.1

UnificationXref222
type: UnificationXref
id: P9WQ21
db: UniProt

UnificationXref223
type: UnificationXref
id: 868619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868619

UnificationXref224
type: UnificationXref
id: REACT_27706
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27706.1

http://identifiers.org/pubmed/16452418
type: PublicationXref
id: 16452418
author: Venketaraman, V
author: Connell, ND
author: Talaue, MT
author: Dayaram, YK
db: Pubmed
title: Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione
source: J Bacteriol 188:1364-72
year: 2006

UnificationXref638
type: UnificationXref
id: 2201256
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2201256

UnificationXref639
type: UnificationXref
id: REACT_124321
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124321.1

UnificationXref636
type: UnificationXref
id: 1641509
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1641509

UnificationXref637
type: UnificationXref
id: REACT_121596
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121596.1

UnificationXref634
type: UnificationXref
id: 1222488
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222488

UnificationXref635
type: UnificationXref
id: REACT_124763
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124763.1

UnificationXref632
type: UnificationXref
id: 1222583
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222583

UnificationXref633
type: UnificationXref
id: REACT_121395
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121395.3

UnificationXref630
type: UnificationXref
id: 1222312
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222312

UnificationXref631
type: UnificationXref
id: REACT_124796
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124796.1

http://identifiers.org/pubmed/14871480
type: PublicationXref
id: 14871480
author: Menge, U
author: Budde, H
author: Radi, R
author: Singh, M
author: Jaeger, T
author: Flohé, L
author: Trujillo, M
db: Pubmed
title: Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis
source: Arch Biochem Biophys 423:182-91
year: 2004

UnificationXref647
type: UnificationXref
id: REACT_122534
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122534.1

UnificationXref648
type: UnificationXref
id: 1222363
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222363

UnificationXref649
type: UnificationXref
id: REACT_121257
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121257.3

UnificationXref643
type: UnificationXref
id: P71971
db: UniProt

UnificationXref644
type: UnificationXref
id: 1222694
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222694

UnificationXref645
type: UnificationXref
id: REACT_125686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125686.1

UnificationXref646
type: UnificationXref
id: 1243099
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1243099

UnificationXref640
type: UnificationXref
id: P9WJM5
db: UniProt

UnificationXref641
type: UnificationXref
id: 1222319
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222319

UnificationXref642
type: UnificationXref
id: REACT_122838
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122838.1

http://identifiers.org/pubmed/17970225
type: PublicationXref
id: 17970225
author: Muse WB, 3rd
author: Carroll, KS
author: Bhave, DP
db: Pubmed
title: Drug targets in mycobacterial sulfur metabolism
source: Infect Disord Drug Targets 7:140-58
year: 2007

UnificationXref207
type: UnificationXref
id: 868608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868608

UnificationXref208
type: UnificationXref
id: REACT_27176
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27176.1

UnificationXref209
type: UnificationXref
id: CHEBI:17306
db: ChEBI

UnificationXref203
type: UnificationXref
id: 29926
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926

UnificationXref204
type: UnificationXref
id: REACT_2525
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2525.2

UnificationXref205
type: UnificationXref
id: 868623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868623

UnificationXref206
type: UnificationXref
id: REACT_27577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27577.1

UnificationXref200
type: UnificationXref
id: 868661
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868661

UnificationXref201
type: UnificationXref
id: REACT_27947
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27947.1

UnificationXref202
type: UnificationXref
id: CHEBI:18420
db: ChEBI

Rv2552c
type: ProteinReference
name: aroE
name: MT2629
name: UniProt:P95001
xref: UnificationXref477
organism: Mycobacterium tuberculosis

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref250

UnificationXref613
type: UnificationXref
id: REACT_125669
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125669.1

UnificationXref612
type: UnificationXref
id: 1500809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500809

Mycothiol [ChEBI:7040]
type: SmallMoleculeReference
name: Mycothiol
xref: UnificationXref80

cfp10A
type: ProteinReference
name: Rv1335
name: UniProt:P9WP33 cysO
name: MTCY130.20
name: cysO
xref: UnificationXref377
comment: FUNCTION: In its thiocarboxylated form (CysO-COSH), is the sulfur donor in the CysM-dependent cysteine biosynthetic pathway. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref611
type: UnificationXref
id: REACT_122177
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122177.1

UnificationXref610
type: UnificationXref
id: 1500820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500820

UnificationXref617
type: UnificationXref
id: 1222392
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222392

UnificationXref260
type: UnificationXref
id: REACT_27593
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27593.1

UnificationXref616
type: UnificationXref
id: P9WG35
db: UniProt

UnificationXref615
type: UnificationXref
id: REACT_120759
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120759.3

UnificationXref614
type: UnificationXref
id: 1500804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500804

UnificationXref253
type: UnificationXref
id: 174375
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174375

UnificationXref252
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref251
type: UnificationXref
id: 29370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref618
type: UnificationXref
id: REACT_123685
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123685.1

UnificationXref619
type: UnificationXref
id: 1222496
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222496

UnificationXref250
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref257
type: UnificationXref
id: REACT_27721
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27721.1

UnificationXref256
type: UnificationXref
id: 936681
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936681

UnificationXref255
type: UnificationXref
id: P71746
db: UniProt

UnificationXref254
type: UnificationXref
id: REACT_7206
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7206.3

UnificationXref259
type: UnificationXref
id: 936743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936743

UnificationXref258
type: UnificationXref
id: P71745
db: UniProt

UnificationXref620
type: UnificationXref
id: REACT_124852
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124852.1

UnificationXref622
type: UnificationXref
id: REACT_123816
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123816.1

UnificationXref621
type: UnificationXref
id: 1222584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222584

UnificationXref624
type: UnificationXref
id: REACT_121400
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121400.3

UnificationXref623
type: UnificationXref
id: 1222755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222755

UnificationXref626
type: UnificationXref
id: 1222631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222631

UnificationXref625
type: UnificationXref
id: CHEBI:59637
db: ChEBI

UnificationXref628
type: UnificationXref
id: 1222594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222594

UnificationXref270
type: UnificationXref
id: REACT_7820
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7820.2

UnificationXref627
type: UnificationXref
id: REACT_123324
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123324.1

UnificationXref271
type: UnificationXref
id: P9WIK1
db: UniProt

UnificationXref629
type: UnificationXref
id: REACT_121129
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121129.3

UnificationXref262
type: UnificationXref
id: 936656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936656

UnificationXref261
type: UnificationXref
id: P9WQM1
db: UniProt

UnificationXref264
type: UnificationXref
id: 936707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936707

UnificationXref263
type: UnificationXref
id: REACT_27540
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27540.1

UnificationXref266
type: UnificationXref
id: 936631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936631

UnificationXref265
type: UnificationXref
id: REACT_27722
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27722.1

http://identifiers.org/pubmed/22101841
type: PublicationXref
id: 22101841
author: Puri, RV
author: Tyagi, AK
author: Khera, A
author: Reddy, PV
db: Pubmed
title: Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection
source: J Bacteriol 194:567-75
year: 2012

Guanosine 5'-triphosphate
type: SmallMoleculeReference
name: GTP
name: GTP [ChEBI:15996]
xref: UnificationXref281

UnificationXref268
type: UnificationXref
id: CHEBI:17709
db: ChEBI

UnificationXref267
type: UnificationXref
id: REACT_27230
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27230.1

UnificationXref269
type: UnificationXref
id: 174370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174370

Rv1336
type: ProteinReference
name: MTCY130.21
name: UniProt:P9WP53 cysM
name: cysM
xref: UnificationXref394
comment: FUNCTION: Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis.
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/18454554
type: PublicationXref
id: 18454554
author: Bertozzi, CR
author: Iavarone, AT
author: Hatzios, SK
db: Pubmed
title: Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase
source: Biochemistry 47:5823-31
year: 2008

carboxymycobactin (loaded)
type: SmallMoleculeReference
name: carboxymycobactin (loaded) [ChEBI:47333]
xref: UnificationXref822

cysK
type: ProteinReference
name: cysK1
name: MTCY98.03
name: Rv2334
name: UniProt:P9WP55 cysK1
xref: UnificationXref361
comment: FUNCTION: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide.
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/16104727
type: PublicationXref
id: 16104727
author: Zhai, H
author: Baumgart, S
author: McLafferty, FW
author: Burns, KE
author: Dorrestein, PC
author: Begley, TP
db: Pubmed
title: Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis
source: J Am Chem Soc 127:11602-3
year: 2005

UnificationXref235
type: UnificationXref
id: REACT_27232
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27232.1

UnificationXref234
type: UnificationXref
id: 868688
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868688

UnificationXref233
type: UnificationXref
id: REACT_27171
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27171.1

UnificationXref232
type: UnificationXref
id: 868657
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868657

UnificationXref231
type: UnificationXref
id: REACT_27714
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27714.1

UnificationXref230
type: UnificationXref
id: 868672
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868672

UnificationXref239
type: UnificationXref
id: REACT_19653
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19653.2

UnificationXref238
type: UnificationXref
id: 427648
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=427648

UnificationXref237
type: UnificationXref
id: CHEBI:16189
db: ChEBI

UnificationXref236
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

http://identifiers.org/pubmed/18799456
type: PublicationXref
id: 18799456
author: Singh, M
author: Oehlmann, W
author: Schnell, R
author: Agren, D
author: Schneider, G
db: Pubmed
title: Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria
source: J Biol Chem 283:31567-74
year: 2008

UnificationXref604
type: UnificationXref
id: REACT_120880
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120880.3

UnificationXref603
type: UnificationXref
id: 1222431
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222431

UnificationXref606
type: UnificationXref
id: 1500786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500786

UnificationXref605
type: UnificationXref
id: P9WIE3
db: UniProt

UnificationXref600
type: UnificationXref
id: REACT_124743
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124743.1

UnificationXref602
type: UnificationXref
id: REACT_122224
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122224.1

UnificationXref601
type: UnificationXref
id: 1222632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222632

UnificationXref244
type: UnificationXref
id: 936734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936734

Acetylbenzene
type: SmallMoleculeReference
name: Phenyl methyl ketone
name: Acetophenone [ChEBI:2403]
name: Methyl phenyl ketone
name: Acetophenone
name: 1-Phenylethanone
xref: UnificationXref105

UnificationXref243
type: UnificationXref
id: REACT_27536
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27536.1

UnificationXref246
type: UnificationXref
id: 936589
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936589

UnificationXref245
type: UnificationXref
id: REACT_27338
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27338.2

UnificationXref240
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref607
type: UnificationXref
id: REACT_123056
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123056.1

UnificationXref608
type: UnificationXref
id: 1500773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500773

PPi
type: SmallMoleculeReference
name: PPi [ChEBI:29888]
xref: UnificationXref61

UnificationXref242
type: UnificationXref
id: 936726
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936726

UnificationXref609
type: UnificationXref
id: REACT_123888
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123888.1

UnificationXref241
type: UnificationXref
id: P71744
db: UniProt

UnificationXref248
type: UnificationXref
id: 936667
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936667

UnificationXref247
type: UnificationXref
id: REACT_27833
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27833.1

UnificationXref249
type: UnificationXref
id: REACT_27286
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27286.1

Formic acid
type: SmallMoleculeReference
name: Formate
name: Formate [ChEBI:30751]
name: Methanoic acid
xref: UnificationXref155

UnificationXref294
type: UnificationXref
id: REACT_27377
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27377.1

UnificationXref295
type: UnificationXref
id: 936671
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936671

UnificationXref296
type: UnificationXref
id: REACT_27382
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27382.2

UnificationXref297
type: UnificationXref
id: 936691
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936691

UnificationXref298
type: UnificationXref
id: REACT_27541
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27541.1

UnificationXref299
type: UnificationXref
id: 936659
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936659

http://identifiers.org/pubmed/10448034
type: PublicationXref
id: 10448034
author: Bachhawat, N
author: Mande, SC
db: Pubmed
title: Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme
source: J Mol Biol 291:531-6
year: 1999

http://identifiers.org/pubmed/1904126
type: PublicationXref
id: 1904126
author: Young, D
author: Zhang, Y
author: Garbe, T
author: Lathigra, R
author: Catty, D
db: Pubmed
title: Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosis
source: Mol Microbiol 5:381-91
year: 1991

Carbonate(2-)
type: SmallMoleculeReference
name: ChEBI:41609 Carbonate(2-)
xref: UnificationXref811

secE
type: ProteinReference
name: MTCY20H10.19
name: Rv0638
name: UniProt:P9WGN7 secE
xref: UnificationXref686
comment: FUNCTION: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Sulfite [ChEBI:9344]
type: SmallMoleculeReference
name: Sulfite
xref: UnificationXref309

UniProt:P9WGN9 secF
type: ProteinReference
name: secF
name: MTCY227.15
name: Rv2586c
xref: UnificationXref689
comment: FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity).
organism: Mycobacterium tuberculosis H37Rv

MTV041.06
type: ProteinReference
name: Rv0732
name: secY
name: UniProt:P9WGN3 secY
xref: UnificationXref680
comment: FUNCTION: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity).
organism: Mycobacterium tuberculosis H37Rv

secG
type: ProteinReference
name: MTCY493.14c
name: Rv1440
name: UniProt:P9WGN5 secG
xref: UnificationXref683
comment: FUNCTION: Involved in protein export. Participates in an early event of protein translocation (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Mec-Zn++
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry49
component stoichiometry: Stoichiometry50
component: Zn(II)
component: Mec+
xref: UnificationXref407
xref: UnificationXref406
cellular location: cytosol
comment: Reactome DB_ID: 936637

AroG-Mn++
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry55
component stoichiometry: Stoichiometry54
component: AroG
component: Mn(III)
xref: UnificationXref449
xref: UnificationXref450
cellular location: cytosol
comment: Reactome DB_ID: 964931

AroG-Mn++ pentamer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry56
component: AroG-Mn++
xref: UnificationXref451
xref: UnificationXref452
cellular location: cytosol
comment: Reactome DB_ID: 964878

MetB holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry52
component stoichiometry: Stoichiometry51
component: Pyridoxal 5'-phosphate
component: MetB
xref: UnificationXref425
xref: UnificationXref424
cellular location: cytosol
comment: Reactome DB_ID: 937237

MetB dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry53
component: MetB holoenzyme
xref: UnificationXref427
xref: UnificationXref426
cellular location: cytosol
comment: Reactome DB_ID: 937193

UnificationXref276
type: UnificationXref
id: REACT_27409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27409.1

UnificationXref277
type: UnificationXref
id: 936606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936606

UnificationXref278
type: UnificationXref
id: REACT_27343
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27343.1

UnificationXref279
type: UnificationXref
id: 936729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936729

UnificationXref272
type: UnificationXref
id: 936698
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936698

UnificationXref273
type: UnificationXref
id: REACT_27787
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27787.1

UnificationXref274
type: UnificationXref
id: P9WNM5
db: UniProt

UnificationXref275
type: UnificationXref
id: 936597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936597

UnificationXref280
type: UnificationXref
id: REACT_27213
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27213.1

UnificationXref282
type: UnificationXref
id: 29438
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

UnificationXref281
type: UnificationXref
id: CHEBI:15996
db: ChEBI

CysK1 dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry43
component stoichiometry: Stoichiometry42
component: Pyridoxal 5'-phosphate
component: CysK1
xref: UnificationXref365
xref: UnificationXref364
cellular location: cytosol
comment: Reactome DB_ID: 936755

CysK2 holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry45
component stoichiometry: Stoichiometry44
component: Pyridoxal 5'-phosphate
component: CysK2
xref: UnificationXref372
xref: UnificationXref371
cellular location: cytosol
comment: Reactome DB_ID: 936725

Ferrodoxin (oxidized)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry36
component stoichiometry: Stoichiometry35
component stoichiometry: Stoichiometry34
component: Fdx
component: (4Fe-4S)(1+)
component: (4Fe-4S)(2+)
xref: UnificationXref335
xref: UnificationXref336
cellular location: cytosol
display name: Fdx(ox.)
comment: Reactome DB_ID: 937267

Sir holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry41
component stoichiometry: Stoichiometry40
component stoichiometry: Stoichiometry39
component: Iron Sulphur Cluster
component: Sir
component: siroheme
xref: UnificationXref343
xref: UnificationXref344
cellular location: cytosol
comment: Reactome DB_ID: 936607

CysM dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry48
component: CysM holoenzyme
xref: UnificationXref399
xref: UnificationXref400
cellular location: cytosol
comment: Reactome DB_ID: 936569

CysM holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry47
component stoichiometry: Stoichiometry46
component: Pyridoxal 5'-phosphate
component: CysM
xref: UnificationXref397
xref: UnificationXref398
cellular location: cytosol
comment: Reactome DB_ID: 936676

cupric ion
type: SmallMoleculeReference
name: Cu(II)
name: copper(2+) [ChEBI:29036]
name: copper(2+)
name: COPPER (II) ION
name: copper(II) cation
name: copper, ion (Cu2+)
name: Cu2+
name: Cu(2+)
xref: UnificationXref709

Fe(3+)
type: SmallMoleculeReference
name: ferric iron
name: Fe(III)
name: Fe3+
name: iron(3+)
name: FE (III) ION
name: Ferric ion
name: iron, ion (Fe(3+))
name: iron(3+) [ChEBI:29034]
xref: UnificationXref552

CysQ-Mg++
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry25
component: CysQ
component: Mg++
xref: UnificationXref295
xref: UnificationXref296
cellular location: plasma membrane
comment: Reactome DB_ID: 936671

CysQ dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry26
component: CysQ-Mg++
xref: UnificationXref297
xref: UnificationXref298
cellular location: plasma membrane
comment: Reactome DB_ID: 936691

Ferrodoxin (reduced)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry31
component stoichiometry: Stoichiometry30
component: Fdx
component: (4Fe-4S)(1+)
xref: UnificationXref328
xref: UnificationXref327
cellular location: cytosol
display name: Fdx(red.)
comment: Reactome DB_ID: 937263

CysH holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry29
component stoichiometry: Stoichiometry28
component: Iron Sulphur Cluster
component: CysH
xref: UnificationXref317
xref: UnificationXref318
cellular location: cytosol
comment: Reactome DB_ID: 936704

UnificationXref289
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1

UnificationXref287
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref288
type: UnificationXref
id: 29420
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

UnificationXref285
type: UnificationXref
id: 158471
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158471

UnificationXref286
type: UnificationXref
id: REACT_7132
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7132.1

UnificationXref283
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref284
type: UnificationXref
id: CHEBI:17980
db: ChEBI

Nitrate
type: SmallMoleculeReference
name: Nitric acid
name: Nitrate [ChEBI:7580]
xref: UnificationXref591

UnificationXref293
type: UnificationXref
id: 936577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936577

UnificationXref292
type: UnificationXref
id: P9WKJ1
db: UniProt

UnificationXref291
type: UnificationXref
id: REACT_27248
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27248.1

UnificationXref290
type: UnificationXref
id: 936583
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936583

UniProt:P9WGP5 secA1
type: ProteinReference
name: MTCY20B11.15c
name: secA1
name: Rv3240c
xref: UnificationXref692
comment: FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of precursor proteins, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).
organism: Mycobacterium tuberculosis H37Rv

secD
type: ProteinReference
name: MTCY227.14
name: UniProt:P9WGP1 secD
name: Rv2587c
xref: UnificationXref677
comment: FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity).
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/10658666
type: PublicationXref
id: 10658666
author: Brown, IN
author: De Smet, KA
author: Weston, A
author: Robertson, BD
author: Young, DB
db: Pubmed
title: Three pathways for trehalose biosynthesis in mycobacteria
source: Microbiology 146:199-208
year: 2000

MTCY1A11.22c
type: ProteinReference
name: Rv1821
name: secA2
name: UniProt:P9WGP3 secA2
xref: UnificationXref674
comment: FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Lactoferrin (loaded)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry117
component stoichiometry: Stoichiometry116
component stoichiometry: Stoichiometry118
component: Lactoferrin
component: iron (ferric)
component: Carbonate (2-)
xref: UnificationXref821
xref: UnificationXref820
cellular location: extracellular region
comment: Reactome DB_ID: 1470056

IrtAB:Rv2895c
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry122
component stoichiometry: Stoichiometry124
component stoichiometry: Stoichiometry123
component: IrtA
component: IrtB
component: Rv2895c
xref: UnificationXref844
xref: UnificationXref843
cellular location: plasma membrane
comment: Reactome DB_ID: 1222486

Lpd dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry113
component stoichiometry: Stoichiometry112
component: Lpd
component: Flavin adenine dinucleotide
xref: UnificationXref762
xref: UnificationXref763
cellular location: cytosol
comment: Reactome DB_ID: 1222635

TrxB dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry115
component stoichiometry: Stoichiometry114
component: TrxB
component: Flavin adenine dinucleotide
xref: UnificationXref771
xref: UnificationXref772
cellular location: cytosol
comment: Reactome DB_ID: 1222425

KatG dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry110
component stoichiometry: Stoichiometry109
component: KatG
component: heme (ferrous)
xref: UnificationXref725
xref: UnificationXref724
cellular location: cytosol
comment: Reactome DB_ID: 1222385

AhpD trimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry111
component: AhpD
xref: UnificationXref745
xref: UnificationXref746
cellular location: cytosol
comment: Reactome DB_ID: 1222514

SodC dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry105
component stoichiometry: Stoichiometry104
component: Copper
component: SodC
xref: UnificationXref716
xref: UnificationXref715
cellular location: plasma membrane
comment: Reactome DB_ID: 1222313

SodB tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry100
component stoichiometry: Stoichiometry101
component: Fe(III)
component: SodB
xref: UnificationXref706
xref: UnificationXref705
cellular location: cytosol
comment: Reactome DB_ID: 1222672

ChEBI:59629 N-ethylsuccinimide-mycothiol conjugate
type: SmallMoleculeReference
name: N-ethylsuccinimide-mycothiol conjugate
xref: UnificationXref113

Sec complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry91
component stoichiometry: Stoichiometry92
component stoichiometry: Stoichiometry95
component stoichiometry: Stoichiometry96
component stoichiometry: Stoichiometry93
component stoichiometry: Stoichiometry94
component stoichiometry: Stoichiometry97
component: SecD
component: SecY
component: SecG
component: SecE
component: SecF
component: SecA1
component: SecA2
xref: UnificationXref695
xref: UnificationXref696
cellular location: plasma membrane
comment: Reactome DB_ID: 1222323

Tpx dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry88
component: Tpx
xref: UnificationXref622
xref: UnificationXref621
cellular location: cytosol
comment: Reactome DB_ID: 1222584

AhpE dimer (ox.)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry82
component: AhpE (ox.)
xref: UnificationXref613
xref: UnificationXref612
cellular location: cytosol
comment: Reactome DB_ID: 1500809

GlbN:Heme dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry71
component stoichiometry: Stoichiometry70
component: heme (ferrous)
component: GlbN
xref: UnificationXref582
xref: UnificationXref581
cellular location: cytosol
comment: Reactome DB_ID: 1222294

GlbN:Ferriheme dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry73
component stoichiometry: Stoichiometry74
component: ferriheme
component: GlbN
xref: UnificationXref590
xref: UnificationXref589
cellular location: cytosol
comment: Reactome DB_ID: 1222369

AhpC hexamer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry80
component: AhpC
xref: UnificationXref602
xref: UnificationXref601
cellular location: cytosol
comment: Reactome DB_ID: 1222632

AhpE dimer (red.)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry81
component: AhpE
xref: UnificationXref608
xref: UnificationXref609
cellular location: cytosol
comment: Reactome DB_ID: 1500773

BfrA dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry64
component stoichiometry: Stoichiometry63
component: BfrA
component: heme
xref: UnificationXref546
xref: UnificationXref545
cellular location: plasma membrane
comment: Reactome DB_ID: 1222438

BfrA complex (iron-loaded)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry67
component stoichiometry: Stoichiometry68
component: iron (ferric)
component: BfrA dimer
xref: UnificationXref556
xref: UnificationXref555
cellular location: plasma membrane
comment: Reactome DB_ID: 1222727

BfrA complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry65
component: BfrA dimer
xref: UnificationXref548
xref: UnificationXref547
cellular location: plasma membrane
comment: Reactome DB_ID: 1222409

AroE dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry58
component: AroE
xref: UnificationXref481
xref: UnificationXref480
cellular location: cytosol
comment: Reactome DB_ID: 964862

AroQ dodecamer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry57
component: AroQ
xref: UnificationXref471
xref: UnificationXref470
cellular location: cytosol
comment: Reactome DB_ID: 964852

AroC-FMN
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry61
component stoichiometry: Stoichiometry62
component: AroC
component: Riboflavin-5-phosphate
xref: UnificationXref512
xref: UnificationXref511
cellular location: cytosol
comment: Reactome DB_ID: 964894

AroK holoenzyme
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry59
component stoichiometry: Stoichiometry60
component: AroK
component: Mg++
xref: UnificationXref490
xref: UnificationXref491
cellular location: cytosol
comment: Reactome DB_ID: 964917

Stickstoffdioxid
type: SmallMoleculeReference
name: nitryl
name: NO2(.)
name: NO2
name: (NO2)(.)
name: [NO2]
name: ONO(.)
name: nitrogen dioxide [ChEBI:33101]
name: nitrogen dioxide
xref: UnificationXref562

Shikimate 3-phosphate
type: SmallMoleculeReference
name: Shikimate 3-phosphate [ChEBI:9134]
name: Shikimate 5-phosphate
xref: UnificationXref484

Peptide-Methionine (S)-Sulfoxide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref528
xref: UnificationXref527
cellular location: cytosol
comment: Reactome DB_ID: 1222452

Peptide-Methionine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref523
xref: UnificationXref522
cellular location: cytosol
comment: Reactome DB_ID: 1222500

Iron Sulphur Cluster
type: PhysicalEntity
data source: Reactome
xref: UnificationXref312
xref: UnificationXref313
cellular location: cytosol
display name: Iron Sulfur Cluster
comment: Reactome DB_ID: 70986

http://identifiers.org/pubmed/15378046
type: PublicationXref
id: 15378046
author: Fang, FC
db: Pubmed
title: Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
source: Nat Rev Microbiol 2:820-32
year: 2004

glucanotrehalose
type: PhysicalEntity
data source: Reactome
xref: UnificationXref220
xref: UnificationXref221
cellular location: cytosol
comment: Reactome DB_ID: 868613

Lipid-OOH
type: PhysicalEntity
data source: Reactome
xref: UnificationXref731
xref: UnificationXref730
cellular location: cytosol
comment: Reactome DB_ID: 1222300

Mycothiol biosynthesis
type: Pathway
data source: Reactome
pathway component: glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol
pathway component: desacetylmycothiol is acetylated to mycothiol using acetyl-CoA
pathway component: acetylglucosamine-inositol is deacetylated by Mca
pathway component: glucose-6-phosphate is converted to inositol-1-phosphate
pathway component: acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate
pathway component: acetylglucosamine-inositol-phosphate is dephosphorylated
xref: UnificationXref99
xref: UnificationXref98
xref: http://identifiers.org/pubmed/16940050
xref: http://identifiers.org/pubmed/14594852
xref: RelationshipXref13
pathway order: PathwayStep5
pathway order: PathwayStep6
pathway order: PathwayStep3
pathway order: PathwayStep4
pathway order: PathwayStep2
pathway order: PathwayStep1
comment: Biosynthesis of mycothiol starts from glucose-6-phosphate and proceeds directly to myo-inositol-1-phosphate, contrary to phosphatidylinositol synthesis. One of the following steps, the removal of the phosphate group, is catalyzed by a still unknown phosphatase. The pathway is essential in M. tuberculosis (Newton et al, 2006; Sareen et al., 2003)
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

Unsaturated lipid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref728
xref: UnificationXref729
cellular location: cytosol
comment: Reactome DB_ID: 1222455

Amino Acid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref654
xref: UnificationXref655
cellular location: periplasmic space
comment: Reactome DB_ID: 2103117

Peptide-Methionine (R)-Sulfoxide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref636
xref: UnificationXref637
cellular location: cytosol
comment: Reactome DB_ID: 1641509

Peptide methionine sulfoxide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref638
xref: UnificationXref639
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2201256
member physical entity: Peptide-Methionine (S)-Sulfoxide
member physical entity: Peptide-Methionine (R)-Sulfoxide

http://identifiers.org/pubmed/15155722
type: PublicationXref
id: 15155722
author: Spagnolo, L
author: D'Orazio, M
author: Törö, I
author: Rotilio, G
author: Pedersen, JZ
author: Carugo, O
author: O'Neill, P
author: Djinovic-Carugo, K
author: Battistoni, A
db: Pubmed
title: Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site
source: J Biol Chem 279:33447-55
year: 2004

Nitrite [ChEBI:7585]
type: SmallMoleculeReference
name: Nitrite
xref: UnificationXref524

http://identifiers.org/pubmed/11483005
type: PublicationXref
id: 11483005
author: Pinto, CA
author: Basso, LA
author: Santos, DS
author: Oliveira, JS
db: Pubmed
title: Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis
source: Protein Expr Purif 22:430-5
year: 2001

BfrB dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry142
component: BfrB
xref: UnificationXref862
xref: UnificationXref863
cellular location: cytosol
comment: Reactome DB_ID: 1562623

BfrA dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry135
component stoichiometry: Stoichiometry136
component: heme (ferrous)
component: BfrA
xref: UnificationXref854
xref: UnificationXref853
cellular location: cytosol
comment: Reactome DB_ID: 1562633

BfrA complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry137
component: BfrA dimer
xref: UnificationXref855
xref: UnificationXref856
cellular location: cytosol
comment: Reactome DB_ID: 1562615

BfrB complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry143
component: BfrB dimer
xref: UnificationXref864
xref: UnificationXref865
cellular location: cytosol
comment: Reactome DB_ID: 1562601

http://identifiers.org/pubmed/14556638
type: PublicationXref
id: 14556638
author: Steffek, M
author: Av-Gay, Y
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase
source: Biochemistry 42:12067-76
year: 2003

UniProt:P9WHH3 mtr
type: ProteinReference
name: gorA
name: mtr
name: Rv2855
xref: UnificationXref176
comment: FUNCTION: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol.
organism: Mycobacterium tuberculosis H37Rv

ChEBI:44348 N-ethylsuccinimide
type: SmallMoleculeReference
name: N-ethylsuccinimide
xref: UnificationXref108

Rv3913
type: ProteinReference
name: UniProt:P9WHH1 trxB
name: MTV028.04
name: trxB2
name: trxB
xref: UnificationXref768
comment: CATALYTIC ACTIVITY: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/14763976
type: PublicationXref
id: 14763976
author: Russell, DG
author: Smith, DA
author: McAlister, MS
author: Kendall, SL
author: Bancroft, GJ
author: Daffe, M
author: Norman, RA
author: Dinadayala, P
author: Rison, SC
author: Stoker, NG
author: Murray-Rust, J
author: McDonald, NQ
author: Movahedzadeh, F
author: Av-Gay, Y
db: Pubmed
title: The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence
source: Mol Microbiol 51:1003-14
year: 2004

MTV038.06
type: ProteinReference
name: lpdC
name: Rv0462
name: UniProt:P9WHH9 lpdC
name: lpd
xref: UnificationXref759
comment: FUNCTION: Lipoamide dehydrogenase is an essential component of the alpha-ketoacid dehydrogenase complexes, namely the pyruvate dehydrogenase (PDH) complex, the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, and likely also the 2-oxoglutarate dehydrogenase (ODH) complex. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Is also able to catalyze the transhydrogenation of NADH and thio-NAD(+) in the absence of D,L-lipoamide, and the NADH-dependent reduction of quinones in vitro.
organism: Mycobacterium tuberculosis H37Rv

ChEBI:59637 S-Nitrosomycothiol
type: SmallMoleculeReference
name: S-Nitrosomycothiol
xref: UnificationXref625

Stoichiometry1
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

ChEBI:59632 (2R)-2-acetamido-3-phenacylsulfanylpropanoic acid
type: SmallMoleculeReference
name: (2R)-2-acetamido-3-phenacylsulfanylpropanoic acid
xref: UnificationXref123

ChEBI:59634 3-(1-ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanoic acid
type: SmallMoleculeReference
name: 3-(1-ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanoic acid
xref: UnificationXref126

Stoichiometry5
type: Stoichiometry
physical entity: Mca
stoichiometric coefficient: 1.0

Stoichiometry4
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: MshC
stoichiometric coefficient: 1.0

acetophenone-mycothiol conjugate
type: SmallMoleculeReference
name: ChEBI:59630 acetophenone-mycothiol conjugate
xref: UnificationXref116

Stoichiometry2
type: Stoichiometry
physical entity: Ino1
stoichiometric coefficient: 1.0

Stoichiometry9
type: Stoichiometry
physical entity: mycothiol
stoichiometric coefficient: 2.0

Stoichiometry8
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

Stoichiometry7
type: Stoichiometry
physical entity: MscR
stoichiometric coefficient: 1.0

Stoichiometry6
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/15721768
type: PublicationXref
id: 15721768
author: Rizzi, C
author: de Souza, BM
author: Gallas, M
author: Basso, LA
author: Weber, PG
author: Frazzon, J
author: Santos, DS
author: Mendes, MA
author: da Fonseca, IO
author: Ely, F
author: Palma, MS
author: Oliveira, JS
db: Pubmed
title: DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme
source: Protein Expr Purif 40:23-30
year: 2005

H2O2
type: SmallMoleculeReference
name: Hydrogen peroxide
name: H2O2 [ChEBI:16240]
xref: UnificationXref702

http://identifiers.org/pubmed/21270886
type: PublicationXref
id: 21270886
author: Andries, K
author: Guillemont, J
author: Koul, A
author: Lounis, N
author: Arnoult, E
db: Pubmed
title: The challenge of new drug discovery for tuberculosis
source: Nature 469:483-90
year: 2011

http://identifiers.org/pubmed/16298142
type: PublicationXref
id: 16298142
author: Magalhães, ML
author: Basso, LA
author: Santos, DS
author: Mendes, MA
author: Fonseca, IO
author: Palma, MS
author: Silva, RG
author: Oliveira, JS
db: Pubmed
title: Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization
source: Protein Expr Purif 46:429-37
year: 2006

Rv0773c
type: ProteinReference
name: UniProt:P71828
name: ggt-1
name: MT0797
name: ggtA
xref: UnificationXref662
organism: Mycobacterium tuberculosis

UDP-N-acetyl-D-glucosamine
type: SmallMoleculeReference
name: UDP-N-acetyl-D-glucosamine [ChEBI:16264]
xref: UnificationXref20

http://identifiers.org/pubmed/8695634
type: PublicationXref
id: 8695634
author: Harrison, PM
author: Arosio, P
db: Pubmed
title: The ferritins: molecular properties, iron storage function and cellular regulation
source: Biochim Biophys Acta 1275:161-203
year: 1996

Chorismate [ChEBI:3677]
type: SmallMoleculeReference
name: Chorismic acid
name: Chorismate
xref: UnificationXref502

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref306

Mycobacterium tuberculosis H37Rv
type: BioSource
xref: UnificationXref11

http://identifiers.org/pubmed/16436075
type: PublicationXref
id: 16436075
author: Yamazaki, M
author: Wada, M
author: Nakamori, S
author: Awano, N
author: Takagi, H
author: Haitani, Y
db: Pubmed
title: Functional analysis of L-serine O-acetyltransferase from Corynebacterium glutamicum
source: FEMS Microbiol Lett 255:156-63
year: 2006

http://identifiers.org/pubmed/11799204
type: PublicationXref
id: 11799204
author: Lima, CD
author: Tempst, P
author: Bryk, R
author: Erdjument-Bromage, H
author: Nathan, C
db: Pubmed
title: Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein
source: Science 295:1073-7
year: 2002

plastid stroma
type: CellularLocationVocabulary
xref: UnificationXref455

UnificationXref599
type: UnificationXref
id: 1222326
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222326

UnificationXref591
type: UnificationXref
id: CHEBI:48107
db: ChEBI

UnificationXref592
type: UnificationXref
id: 432031
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=432031

UnificationXref593
type: UnificationXref
id: REACT_24630
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24630.3

UnificationXref594
type: UnificationXref
id: 1222723
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222723

UnificationXref595
type: UnificationXref
id: REACT_121052
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121052.3

UnificationXref596
type: UnificationXref
id: P9WQB7
db: UniProt

UnificationXref597
type: UnificationXref
id: 1222710
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222710

UnificationXref598
type: UnificationXref
id: REACT_123259
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123259.1

UnificationXref301
type: UnificationXref
id: 936635
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936635

UnificationXref300
type: UnificationXref
id: REACT_27229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27229.1

UnificationXref309
type: UnificationXref
id: CHEBI:48854
db: ChEBI

UnificationXref308
type: UnificationXref
id: REACT_122036
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122036.1

UnificationXref590
type: UnificationXref
id: REACT_125635
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125635.1

UnificationXref307
type: UnificationXref
id: 1222293
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222293

UnificationXref306
type: UnificationXref
id: MOD:00798
db: MOD

UnificationXref305
type: UnificationXref
id: REACT_27438
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27438.1

UnificationXref304
type: UnificationXref
id: 936674
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936674

UnificationXref303
type: UnificationXref
id: P9WG67
db: UniProt

UnificationXref302
type: UnificationXref
id: REACT_27155
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27155.1

UnificationXref587
type: UnificationXref
id: 917795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=917795

UnificationXref586
type: UnificationXref
id: CHEBI:36144
db: ChEBI

UnificationXref585
type: UnificationXref
id: REACT_123799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123799.1

UnificationXref584
type: UnificationXref
id: 1222525
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222525

http://identifiers.org/pubmed/19737009
type: PublicationXref
id: 19737009
author: Monteiro, G
author: Manta, B
author: Alvarez, B
author: Radi, R
author: Netto, LE
author: Botti, H
author: Hugo, M
author: Trujillo, M
author: Turell, L
db: Pubmed
title: Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
source: Biochemistry 48:9416-26
year: 2009

UnificationXref583
type: UnificationXref
id: CHEBI:29120
db: ChEBI

UnificationXref582
type: UnificationXref
id: REACT_124216
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124216.1

UnificationXref581
type: UnificationXref
id: 1222294
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222294

UnificationXref580
type: UnificationXref
id: REACT_2784
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2784.3

UnificationXref589
type: UnificationXref
id: 1222369
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222369

UnificationXref588
type: UnificationXref
id: REACT_25787
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25787.2

trx-2
type: ProteinReference
name: Rv1471
name: UniProt:Q7D8E1
name: trxB1
name: MT1517
xref: UnificationXref775
organism: Mycobacterium tuberculosis

ChEBI:15138 sulfide
type: SmallMoleculeReference
name: sulfide
xref: UnificationXref329

http://identifiers.org/pubmed/17638697
type: PublicationXref
id: 17638697
author: Av-Gay, Y
author: Johnson, T
author: Miller, CC
author: Rawat, M
db: Pubmed
title: Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol
source: Antimicrob Agents Chemother 51:3364-6
year: 2007

http://identifiers.org/pubmed/17644602
type: PublicationXref
id: 17644602
author: Hsu, T
author: Jacobs WR, Jr
author: Leyh, TS
author: Harrison, JS
author: Pinto, R
db: Pubmed
title: Sulfite reduction in mycobacteria
source: J Bacteriol 189:6714-22
year: 2007

UnificationXref574
type: UnificationXref
id: 29368
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368

UnificationXref573
type: UnificationXref
id: CHEBI:15379
db: ChEBI

UnificationXref576
type: UnificationXref
id: P9WN25
db: UniProt

UnificationXref575
type: UnificationXref
id: REACT_5251
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5251.2

UnificationXref570
type: UnificationXref
id: REACT_13183
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13183.2

UnificationXref572
type: UnificationXref
id: REACT_120941
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120941.3

UnificationXref571
type: UnificationXref
id: 1500761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500761

UnificationXref578
type: UnificationXref
id: REACT_123727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123727.1

UnificationXref577
type: UnificationXref
id: 1222724
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222724

UnificationXref579
type: UnificationXref
id: 71185
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185

UnificationXref561
type: UnificationXref
id: REACT_121595
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121595.1

UnificationXref560
type: UnificationXref
id: 1500819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500819

UnificationXref565
type: UnificationXref
id: CHEBI:1130536
db: ChEBI

UnificationXref564
type: UnificationXref
id: REACT_123216
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123216.1

UnificationXref563
type: UnificationXref
id: 1500793
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500793

UnificationXref562
type: UnificationXref
id: CHEBI:33101
db: ChEBI

UnificationXref569
type: UnificationXref
id: 202124
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=202124

UnificationXref568
type: UnificationXref
id: CHEBI:16480
db: ChEBI

UnificationXref567
type: UnificationXref
id: REACT_123236
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123236.1

UnificationXref566
type: UnificationXref
id: 1130536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1130536

S-Nitrosoglutathione
type: SmallMoleculeReference
name: ChEBI:50091 S-Nitrosoglutathione
xref: UnificationXref651

UnificationXref550
type: UnificationXref
id: 71067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71067

UnificationXref552
type: UnificationXref
id: CHEBI:29034
db: ChEBI

UnificationXref551
type: UnificationXref
id: REACT_3428
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3428.2

UnificationXref554
type: UnificationXref
id: REACT_201018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201018.1

UnificationXref553
type: UnificationXref
id: 1222433
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222433

UnificationXref556
type: UnificationXref
id: REACT_201404
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201404.1

UnificationXref555
type: UnificationXref
id: 1222727
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222727

UnificationXref558
type: UnificationXref
id: REACT_200747
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_200747.1

UnificationXref557
type: UnificationXref
id: 1222605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222605

UnificationXref559
type: UnificationXref
id: CHEBI:1500819
db: ChEBI

http://identifiers.org/pubmed/19040639
type: PublicationXref
id: 19040639
author: St John, G
author: de Carvalho, LP
author: Gold, B
author: Jacobs WR, Jr
author: Jiang, X
author: Wellner, D
author: Lee, WL
author: Brot, N
author: Darby, C
author: Nathan, C
db: Pubmed
title: Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite
source: Mol Microbiol 71:583-93
year: 2009

http://identifiers.org/pubmed/18842002
type: PublicationXref
id: 18842002
author: Jurgenson, CT
author: O'Leary, SE
author: Ealick, SE
author: Begley, TP
db: Pubmed
title: O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis
source: Biochemistry 47:11606-15
year: 2008

UnificationXref751
type: UnificationXref
id: REACT_121598
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121598.1

Stoichiometry18
type: Stoichiometry
physical entity: CysW
stoichiometric coefficient: 1.0

UnificationXref752
type: UnificationXref
id: 1222687
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222687

Stoichiometry17
type: Stoichiometry
physical entity: SubI
stoichiometric coefficient: 1.0

UnificationXref750
type: UnificationXref
id: 1222478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222478

Stoichiometry19
type: Stoichiometry
physical entity: CysT
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/17804665
type: PublicationXref
id: 17804665
author: Miethke, M
author: Marahiel, MA
db: Pubmed
title: Siderophore-based iron acquisition and pathogen control
source: Microbiol Mol Biol Rev 71:413-51
year: 2007

UnificationXref759
type: UnificationXref
id: P9WHH9
db: UniProt

UnificationXref757
type: UnificationXref
id: 29386
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

UnificationXref758
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

UnificationXref755
type: UnificationXref
id: REACT_121040
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121040.3

UnificationXref756
type: UnificationXref
id: CHEBI:16238
db: ChEBI

UnificationXref753
type: UnificationXref
id: REACT_122603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122603.1

UnificationXref754
type: UnificationXref
id: 1222690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222690

Stoichiometry10
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry11
type: Stoichiometry
physical entity: electron
stoichiometric coefficient: 2.0

Stoichiometry12
type: Stoichiometry
physical entity: mycothiol
stoichiometric coefficient: 2.0

Stoichiometry13
type: Stoichiometry
physical entity: OtsA
stoichiometric coefficient: 4.0

Stoichiometry14
type: Stoichiometry
physical entity: OtsB
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/16884737
type: PublicationXref
id: 16884737
author: Terwilliger, TC
author: Park, MS
author: Holton, JM
author: Pédelacq, JD
author: Kim, SI
author: Hung, LW
author: Rho, BS
author: Vigil, D
db: Pubmed
title: Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis
source: J Mol Biol 361:850-63
year: 2006

Stoichiometry15
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry16
type: Stoichiometry
physical entity: sulfate
stoichiometric coefficient: 1.0

UnificationXref760
type: UnificationXref
id: 1222708
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222708

UnificationXref761
type: UnificationXref
id: REACT_124212
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124212.1

UnificationXref762
type: UnificationXref
id: 1222635
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222635

Stoichiometry29
type: Stoichiometry
physical entity: CysH
stoichiometric coefficient: 1.0

UnificationXref763
type: UnificationXref
id: REACT_123663
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123663.1

Stoichiometry28
type: Stoichiometry
physical entity: Iron Sulphur Cluster
stoichiometric coefficient: 1.0

iron (ferrous)
type: SmallMoleculeReference
name: iron (ferrous) [ChEBI:18248]
name: Fe2+
name: Fe(II)
name: Fe++
xref: UnificationXref549

UnificationXref768
type: UnificationXref
id: P9WHH1
db: UniProt

UnificationXref769
type: UnificationXref
id: 1222537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222537

UnificationXref764
type: UnificationXref
id: 1222412
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222412

UnificationXref765
type: UnificationXref
id: REACT_120779
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120779.3

UnificationXref766
type: UnificationXref
id: 1222417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222417

UnificationXref767
type: UnificationXref
id: REACT_120911
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120911.3

ferriheme
type: SmallMoleculeReference
name: ferriheme b
name: ChEBI:36144 ferriheme
xref: UnificationXref586

Stoichiometry22
type: Stoichiometry
physical entity: CysNC
stoichiometric coefficient: 1.0

Stoichiometry23
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry20
type: Stoichiometry
physical entity: CysA
stoichiometric coefficient: 2.0

Stoichiometry21
type: Stoichiometry
physical entity: CysD
stoichiometric coefficient: 1.0

Stoichiometry26
type: Stoichiometry
physical entity: CysQ-Mg++
stoichiometric coefficient: 2.0

Stoichiometry27
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry24
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry25
type: Stoichiometry
physical entity: CysQ
stoichiometric coefficient: 1.0

UnificationXref770
type: UnificationXref
id: REACT_124318
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124318.1

UnificationXref773
type: UnificationXref
id: 1222485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222485

UnificationXref774
type: UnificationXref
id: REACT_121244
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121244.3

UnificationXref771
type: UnificationXref
id: 1222425
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222425

UnificationXref772
type: UnificationXref
id: REACT_124367
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124367.1

UnificationXref777
type: UnificationXref
id: REACT_125396
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125396.1

UnificationXref778
type: UnificationXref
id: 1243096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1243096

UnificationXref775
type: UnificationXref
id: Q7D8E1
db: UniProt

UnificationXref776
type: UnificationXref
id: 1222614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222614

UnificationXref779
type: UnificationXref
id: REACT_121610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121610.1

http://identifiers.org/pubmed/15703182
type: PublicationXref
id: 15703182
author: Mischenko, VV
author: McAlister, MS
author: Harris, R
author: Driscoll, PC
author: Murphy, HN
author: Robertson, BD
author: Stewart, GR
author: Young, DB
author: Apt, AS
db: Pubmed
title: The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis
source: J Biol Chem 280:14524-9
year: 2005

Zinc [ChEBI:29105]
type: SmallMoleculeReference
name: Zinc
name: Zn2+
name: Zn(II)
xref: UnificationXref8

UnificationXref780
type: UnificationXref
id: 1222479
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222479

UnificationXref781
type: UnificationXref
id: REACT_123798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123798.1

UnificationXref782
type: UnificationXref
id: 1243098
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1243098

UnificationXref783
type: UnificationXref
id: REACT_124277
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124277.1

UnificationXref784
type: UnificationXref
id: 1222644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222644

UnificationXref785
type: UnificationXref
id: REACT_121268
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121268.3

UnificationXref786
type: UnificationXref
id: CHEBI:16938
db: ChEBI

UnificationXref787
type: UnificationXref
id: 31467
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31467

GIG12
type: ProteinReference
name: UniProt:P02788 LTF
name: LTF
name: LF
xref: UnificationXref815
comment: CATALYTIC ACTIVITY Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.PTM Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.POLYMORPHISM The sequence shown corresponds to the reference genome sequence and is likely to represent the minor allele, whereas most publications refer to the longer sequence containing variant Arg-22 ins. Insertion of the additional arginine in variant Arg-22 ins creates an N-terminal basic cluster of four arginines, all of which appear to be important for the full functionality of the protein, including bactericidal and antifungal activities as well as binding to glycosaminoglycans, pspA, LPS, lysozyme and DNA.SIMILARITY Belongs to the transferrin family.SIMILARITY Contains 2 transferrin-like domains.
organism: Homo sapiens

UnificationXref788
type: UnificationXref
id: REACT_4982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4982.1

UnificationXref789
type: UnificationXref
id: P9WNE1
db: UniProt

UniProt:P9WNM5 cysNC
type: ProteinReference
name: Rv1286
name: cysN
name: MTCY373.05
name: cysNC
xref: UnificationXref274
comment: FUNCTION: ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity (By similarity).
organism: Mycobacterium tuberculosis H37Rv

UnificationXref100
type: UnificationXref
id: MI:0359
db: MI

UnificationXref101
type: UnificationXref
id: 879281
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879281

UnificationXref102
type: UnificationXref
id: REACT_27249
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27249.1

UnificationXref103
type: UnificationXref
id: 879325
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879325

UnificationXref104
type: UnificationXref
id: REACT_27144
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27144.1

UnificationXref105
type: UnificationXref
id: CHEBI:27632
db: ChEBI

UnificationXref106
type: UnificationXref
id: 879294
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879294

UnificationXref107
type: UnificationXref
id: REACT_27752
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27752.2

UnificationXref108
type: UnificationXref
id: CHEBI:44348
db: ChEBI

UnificationXref109
type: UnificationXref
id: 879288
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879288

UnificationXref716
type: UnificationXref
id: REACT_122453
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122453.1

UnificationXref715
type: UnificationXref
id: 1222313
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222313

UnificationXref714
type: UnificationXref
id: REACT_125478
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125478.1

UnificationXref713
type: UnificationXref
id: 1222633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222633

UnificationXref712
type: UnificationXref
id: P9WGE9
db: UniProt

UnificationXref711
type: UnificationXref
id: REACT_20939
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20939.2

UnificationXref710
type: UnificationXref
id: 209799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209799

UnificationXref119
type: UnificationXref
id: 879246
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879246

UnificationXref118
type: UnificationXref
id: REACT_27525
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27525.2

UnificationXref117
type: UnificationXref
id: 879244
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879244

UnificationXref116
type: UnificationXref
id: CHEBI:59630
db: ChEBI

oxidonitrogen(1+)
type: SmallMoleculeReference
name: nitrosonium
name: ChEBI:29120 oxidonitrogen(1+)
xref: UnificationXref583

UnificationXref115
type: UnificationXref
id: REACT_27604
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27604.1

UnificationXref114
type: UnificationXref
id: 879283
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879283

UnificationXref113
type: UnificationXref
id: CHEBI:59629
db: ChEBI

UnificationXref112
type: UnificationXref
id: REACT_27656
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27656.1

UnificationXref111
type: UnificationXref
id: 879233
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879233

UnificationXref719
type: UnificationXref
id: 1222346
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222346

UnificationXref110
type: UnificationXref
id: REACT_27385
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27385.2

UnificationXref717
type: UnificationXref
id: 1222469
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222469

UnificationXref718
type: UnificationXref
id: REACT_121151
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121151.3

UnificationXref725
type: UnificationXref
id: REACT_123044
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123044.1

UnificationXref724
type: UnificationXref
id: 1222385
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222385

UnificationXref727
type: UnificationXref
id: REACT_121262
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121262.3

UnificationXref726
type: UnificationXref
id: 1222704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222704

UnificationXref721
type: UnificationXref
id: P9WIE5
db: UniProt

UnificationXref720
type: UnificationXref
id: REACT_121090
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121090.3

UnificationXref723
type: UnificationXref
id: REACT_121480
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121480.1

UnificationXref722
type: UnificationXref
id: 1222678
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222678

S-(glycyl)-L-cysteine (Gly)
type: SequenceModificationVocabulary
xref: UnificationXref391

UnificationXref127
type: UnificationXref
id: 879279
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879279

UnificationXref126
type: UnificationXref
id: CHEBI:59634
db: ChEBI

UnificationXref129
type: UnificationXref
id: 879237
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879237

UnificationXref128
type: UnificationXref
id: REACT_27332
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27332.1

UnificationXref123
type: UnificationXref
id: CHEBI:59632
db: ChEBI

UnificationXref122
type: UnificationXref
id: REACT_27143
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27143.1

UnificationXref125
type: UnificationXref
id: REACT_27320
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27320.2

UnificationXref124
type: UnificationXref
id: 879267
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879267

UnificationXref728
type: UnificationXref
id: 1222455
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222455

UnificationXref729
type: UnificationXref
id: REACT_123804
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123804.1

UnificationXref121
type: UnificationXref
id: 879273
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879273

UnificationXref120
type: UnificationXref
id: REACT_27473
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27473.1

UnificationXref734
type: UnificationXref
id: 1222348
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222348

UnificationXref733
type: UnificationXref
id: REACT_121370
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121370.3

UnificationXref732
type: UnificationXref
id: 1222341
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222341

UnificationXref731
type: UnificationXref
id: REACT_125320
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125320.1

UnificationXref738
type: UnificationXref
id: 1222387
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222387

UnificationXref737
type: UnificationXref
id: REACT_121359
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121359.3

5-enolpyruvyl shikimate-3-phosphate
type: SmallMoleculeReference
name: ChEBI:57701 5-enolpyruvyl shikimate-3-phosphate
xref: UnificationXref494

UnificationXref736
type: UnificationXref
id: 1222526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222526

UnificationXref735
type: UnificationXref
id: REACT_124444
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124444.1

UnificationXref730
type: UnificationXref
id: 1222300
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222300

UnificationXref139
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref138
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

UnificationXref137
type: UnificationXref
id: 29360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

http://identifiers.org/pubmed/20494107
type: PublicationXref
id: 20494107
author: Schnell, R
author: Schneider, G
db: Pubmed
title: Structural enzymology of sulphur metabolism in Mycobacterium tuberculosis
source: Biochem Biophys Res Commun 396:33-8
year: 2010

Maltose [ChEBI:6668]
type: SmallMoleculeReference
name: Malt sugar
name: 1-alpha-D-Glucopyranosyl-4-alpha-D-glucopyranose
name: Maltose
xref: UnificationXref209

UnificationXref132
type: UnificationXref
id: REACT_27304
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27304.1

UnificationXref131
type: UnificationXref
id: 879311
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879311

UnificationXref739
type: UnificationXref
id: REACT_121009
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121009.3

UnificationXref130
type: UnificationXref
id: REACT_27450
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27450.1

UnificationXref136
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref135
type: UnificationXref
id: REACT_27709
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27709.2

http://identifiers.org/pubmed/12072441
type: PublicationXref
id: 12072441
author: Senaratne, RH
author: Bertozzi, CR
author: Mougous, JD
author: Williams, SJ
author: Riley, LW
db: Pubmed
title: 5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria
source: J Biol Chem 277:32606-15
year: 2002

UnificationXref134
type: UnificationXref
id: 879250
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879250

Sulfate assimilation
type: Pathway
data source: Reactome
pathway component: APS is phosphorylated to PAPS
pathway component: PAPS is dephosphorylated to APS
pathway component: sulfate is activated to APS
pathway component: sulfate uptake in the cytosol
pathway component: sulfate binds to SubI outside the membrane
xref: UnificationXref301
xref: http://identifiers.org/pubmed/17970225
xref: RelationshipXref41
xref: UnificationXref302
pathway order: PathwayStep28
pathway order: PathwayStep27
pathway order: PathwayStep26
pathway order: PathwayStep25
pathway order: PathwayStep24
comment: Authored: Stephan, R, 2010-06-17
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Uptake of sulfur in Mycobacterium tuberculosis happens exclusively through sulfate assimiliation, an abundant molecule in the bacterium's environment. All enzymes participating in this process are non-redundant ie they are essential enzymes. Sulfate is first taken up via an ABC transporter and appended to AMP giving APS and PAPS, which can be considered the activated forms of sulfate and are used in cysteine and sulfolipid biosynthesis (Bhave et al, 2007).
organism: Mycobacterium tuberculosis

UnificationXref133
type: UnificationXref
id: CHEBI:16842
db: ChEBI

UnificationXref743
type: UnificationXref
id: 1222360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222360

UnificationXref742
type: UnificationXref
id: REACT_123534
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123534.1

UnificationXref745
type: UnificationXref
id: 1222514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222514

UnificationXref744
type: UnificationXref
id: REACT_123010
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123010.1

UnificationXref747
type: UnificationXref
id: 1222655
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222655

UnificationXref746
type: UnificationXref
id: REACT_122585
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122585.1

UnificationXref749
type: UnificationXref
id: P9WIS7
db: UniProt

UnificationXref748
type: UnificationXref
id: REACT_121243
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121243.3

UnificationXref150
type: UnificationXref
id: REACT_27801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27801.1

UnificationXref741
type: UnificationXref
id: 1222304
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222304

UnificationXref740
type: UnificationXref
id: P9WQB5
db: UniProt

UnificationXref149
type: UnificationXref
id: 879330
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879330

UnificationXref148
type: UnificationXref
id: O53533
db: UniProt

UnificationXref141
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref140
type: UnificationXref
id: 73473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref143
type: UnificationXref
id: 879271
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879271

UnificationXref142
type: UnificationXref
id: CHEBI:15735
db: ChEBI

APS
type: SmallMoleculeReference
name: Adenosine 5'-phosphosulfate
name: Adenylylsulfate
name: Adenylylsulfate [ChEBI:17709]
xref: UnificationXref268

cell wall
type: CellularLocationVocabulary
xref: UnificationXref806

UnificationXref145
type: UnificationXref
id: CHEBI:15378
db: ChEBI

UnificationXref144
type: UnificationXref
id: REACT_27628
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27628.2

UnificationXref147
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

UnificationXref146
type: UnificationXref
id: 70106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

Stoichiometry91
type: Stoichiometry
physical entity: SecA2
stoichiometric coefficient: 1.0

UnificationXref155
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Stoichiometry92
type: Stoichiometry
physical entity: SecD
stoichiometric coefficient: 1.0

UnificationXref156
type: UnificationXref
id: 29460
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29460

UnificationXref157
type: UnificationXref
id: REACT_4966
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4966.2

Stoichiometry90
type: Stoichiometry
physical entity: DPN
stoichiometric coefficient: 2.0

UnificationXref158
type: UnificationXref
id: 879293
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879293

Stoichiometry95
type: Stoichiometry
physical entity: SecE
stoichiometric coefficient: 4.0

UnificationXref151
type: UnificationXref
id: 1222283
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222283

Stoichiometry96
type: Stoichiometry
physical entity: SecF
stoichiometric coefficient: 1.0

UnificationXref152
type: UnificationXref
id: REACT_27528
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27528.2

Stoichiometry93
type: Stoichiometry
physical entity: SecY
stoichiometric coefficient: 4.0

UnificationXref153
type: UnificationXref
id: 879245
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879245

Stoichiometry94
type: Stoichiometry
physical entity: SecG
stoichiometric coefficient: 4.0

UnificationXref154
type: UnificationXref
id: REACT_27190
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27190.1

MTCY130.19
type: ProteinReference
name: Rv1334
name: mec
name: UniProt:P9WHS1 mec
name: mec+
xref: UnificationXref403
comment: FUNCTION: Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO.
organism: Mycobacterium tuberculosis H37Rv

Stoichiometry99
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

FAD [ChEBI:16238]
type: SmallMoleculeReference
name: FAD
name: Flavin adenine dinucleotide
xref: UnificationXref756

Stoichiometry97
type: Stoichiometry
physical entity: SecA1
stoichiometric coefficient: 2.0

Stoichiometry98
type: Stoichiometry
physical entity: SO2.-
stoichiometric coefficient: 2.0

UnificationXref159
type: UnificationXref
id: REACT_27193
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27193.1

Catalysis1
type: Catalysis
data source: Reactome
controlled: glucose-6-phosphate is converted to inositol-1-phosphate
control type: ACTIVATION
xref: RelationshipXref1
xref: RelationshipXref2
controller: Ino1-Zn2+

UnificationXref161
type: UnificationXref
id: REACT_27281
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27281.1

Cystathionine
type: SmallMoleculeReference
name: Cystathionine [ChEBI:4048]
xref: UnificationXref412

UnificationXref160
type: UnificationXref
id: 879235
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879235

UnificationXref168
type: UnificationXref
id: 879266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879266

Mycothiol catabolism
type: Pathway
data source: Reactome
pathway component: mycothiol is cleaved to acetylcysteine and glucosaminylinositol
xref: UnificationXref103
xref: UnificationXref104
xref: http://identifiers.org/pubmed/17286835
xref: http://identifiers.org/pubmed/18772286
xref: RelationshipXref16
pathway order: PathwayStep8
comment: Edited: Jassal, B, 2011-02-16
comment: Mycothiol and its adducts that result from detoxification can be readily cleaved into smaller molecules. The mycothiol pool therefore serves as storage for unstable cysteine and sugars. (Rawat and Av-Gay, 2007; Newton et al, 2008)
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-12
organism: Mycobacterium tuberculosis

UnificationXref169
type: UnificationXref
id: REACT_27231
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27231.1

UnificationXref166
type: UnificationXref
id: 879326
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879326

UnificationXref167
type: UnificationXref
id: REACT_27785
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27785.2

UnificationXref164
type: UnificationXref
id: REACT_27791
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27791.2

UnificationXref165
type: UnificationXref
id: CHEBI:10545
db: ChEBI

UnificationXref162
type: UnificationXref
id: CHEBI:16086
db: ChEBI

UnificationXref163
type: UnificationXref
id: 879252
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879252

Catalysis8
type: Catalysis
data source: Reactome
controlled: mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins
control type: ACTIVATION
xref: RelationshipXref15
xref: RelationshipXref14
controller: Mca-Zn++

Catalysis9
type: Catalysis
data source: Reactome
controlled: mycothiol binds formaldehyde and is dehydrogenated
control type: ACTIVATION
xref: RelationshipXref18
xref: RelationshipXref17
controller: MscR:Zn2+

Catalysis6
type: Catalysis
data source: Reactome
controlled: acetylglucosamine-inositol is deacetylated by Mca
control type: ACTIVATION
xref: RelationshipXref12
xref: RelationshipXref11
controller: Mca-Zn++

Catalysis7
type: Catalysis
data source: Reactome
controlled: mycothiol is cleaved to acetylcysteine and glucosaminylinositol
control type: ACTIVATION
xref: RelationshipXref15
xref: RelationshipXref14
controller: Mca-Zn++

Catalysis4
type: Catalysis
data source: Reactome
controlled: glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol
control type: ACTIVATION
xref: RelationshipXref8
xref: RelationshipXref7
controller: MshC-Zn2+

Catalysis5
type: Catalysis
data source: Reactome
controlled: desacetylmycothiol is acetylated to mycothiol using acetyl-CoA
control type: ACTIVATION
xref: RelationshipXref10
xref: RelationshipXref9
controller: MshD

Catalysis2
type: Catalysis
data source: Reactome
controlled: acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: MshA

Catalysis3
type: Catalysis
data source: Reactome
controlled: acetylglucosamine-inositol-phosphate is dephosphorylated
control type: ACTIVATION
xref: RelationshipXref5
xref: RelationshipXref6
controller: ImpC

L-Serine
type: SmallMoleculeReference
name: L-Serine [ChEBI:17115]
xref: UnificationXref347

3-Dehydroshikimate
type: SmallMoleculeReference
name: ChEBI:16630 3-Dehydroshikimate
xref: UnificationXref464

UnificationXref172
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

UnificationXref171
type: UnificationXref
id: 29364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

UnificationXref170
type: UnificationXref
id: CHEBI:16474
db: ChEBI

UnificationXref173
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Stoichiometry73
type: Stoichiometry
physical entity: GlbN
stoichiometric coefficient: 2.0

UnificationXref174
type: UnificationXref
id: 29366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

Stoichiometry74
type: Stoichiometry
physical entity: ferriheme
stoichiometric coefficient: 2.0

UnificationXref175
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

Stoichiometry71
type: Stoichiometry
physical entity: heme (ferrous)
stoichiometric coefficient: 2.0

Carboxymycobactin:Fe3+
type: SmallMolecule
entity reference: carboxymycobactin (loaded)
data source: Reactome
xref: UnificationXref823
xref: UnificationXref824
cellular location: extracellular region
comment: Reactome DB_ID: 1222630

UnificationXref176
type: UnificationXref
id: P9WHH3
db: UniProt

Stoichiometry72
type: Stoichiometry
physical entity: NO+
stoichiometric coefficient: 2.0

UnificationXref177
type: UnificationXref
id: 879285
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879285

UnificationXref178
type: UnificationXref
id: REACT_27374
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27374.1

Stoichiometry70
type: Stoichiometry
physical entity: GlbN
stoichiometric coefficient: 2.0

UnificationXref179
type: UnificationXref
id: 879322
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879322

http://identifiers.org/pubmed/9395452
type: PublicationXref
id: 9395452
author: Cass, AE
author: Brown, KA
author: Nagy, JM
db: Pubmed
title: Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis
source: J Biol Chem 272:31265-71
year: 1997

Stoichiometry79
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry77
type: Stoichiometry
physical entity: Nitrite
stoichiometric coefficient: 2.0

Stoichiometry78
type: Stoichiometry
physical entity: AhpC(ox.)
stoichiometric coefficient: 2.0

Stoichiometry75
type: Stoichiometry
physical entity: Peroxynitrite
stoichiometric coefficient: 2.0

Stoichiometry76
type: Stoichiometry
physical entity: AhpC
stoichiometric coefficient: 2.0

Mycobactin:Fe3+
type: SmallMolecule
entity reference: ChEBI:61174 Mycobactin T:iron
data source: Reactome
xref: UnificationXref829
xref: UnificationXref828
cellular location: cell wall
comment: Reactome DB_ID: 1222539

Mycobactin:Fe3+
type: SmallMolecule
entity reference: ChEBI:61174 Mycobactin T:iron
data source: Reactome
xref: UnificationXref833
xref: UnificationXref832
cellular location: cytosol
comment: Reactome DB_ID: 1222331

iron (ferric)
type: SmallMolecule
entity reference: Fe(3+)
data source: Reactome
xref: UnificationXref849
xref: UnificationXref850
cellular location: cytosol
comment: Reactome DB_ID: 111736
display name: Fe3+

UnificationXref181
type: UnificationXref
id: 870331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870331

UnificationXref180
type: UnificationXref
id: REACT_27243
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27243.1

UnificationXref183
type: UnificationXref
id: CHEBI:18066
db: ChEBI

UnificationXref182
type: UnificationXref
id: REACT_27191
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27191.1

UnificationXref709
type: UnificationXref
id: CHEBI:29036
db: ChEBI

UnificationXref186
type: UnificationXref
id: CHEBI:18283
db: ChEBI

Stoichiometry82
type: Stoichiometry
physical entity: AhpE (ox.)
stoichiometric coefficient: 2.0

UnificationXref708
type: UnificationXref
id: REACT_120864
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120864.3

UnificationXref187
type: UnificationXref
id: 868701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868701

Stoichiometry83
type: Stoichiometry
physical entity: Peroxynitrite
stoichiometric coefficient: 2.0

UnificationXref707
type: UnificationXref
id: 1222462
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222462

UnificationXref184
type: UnificationXref
id: 29410
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29410

Stoichiometry84
type: Stoichiometry
physical entity: Tpx
stoichiometric coefficient: 2.0

UnificationXref706
type: UnificationXref
id: REACT_125005
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125005.1

UnificationXref185
type: UnificationXref
id: REACT_3006
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3006.3

Stoichiometry85
type: Stoichiometry
physical entity: Nitrite
stoichiometric coefficient: 2.0

UnificationXref188
type: UnificationXref
id: REACT_27652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27652.1

Stoichiometry80
type: Stoichiometry
physical entity: AhpC
stoichiometric coefficient: 6.0

UnificationXref189
type: UnificationXref
id: P9WN11
db: UniProt

Stoichiometry81
type: Stoichiometry
physical entity: AhpE
stoichiometric coefficient: 2.0

Cysteine synthesis from O-phosphoserine
type: Pathway
data source: Reactome
pathway component: sulfur transfer to carrier protein
pathway component: OPS is added to the carrier sulfide
pathway component: cleavage of L-cysteine from carrier protein
xref: http://identifiers.org/pubmed/18799456
xref: RelationshipXref51
xref: UnificationXref411
xref: UnificationXref410
pathway order: PathwayStep36
pathway order: PathwayStep37
pathway order: PathwayStep38
comment: In stress situations, Mycobacteria express enzymes for a second pathway that enables cysteine synthesis from serine pathway products, here from phosphoserine. The details of the sulfur donor are not established (Agren et al, 2008).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-08-10
organism: Mycobacterium tuberculosis

http://identifiers.org/pubmed/11171096
type: PublicationXref
id: 11171096
author: Chauhan, R
author: Mande, SC
db: Pubmed
title: Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity
source: Biochem J 354:209-15
year: 2001

Stoichiometry86
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry87
type: Stoichiometry
physical entity: Tpx(ox.)
stoichiometric coefficient: 2.0

Stoichiometry88
type: Stoichiometry
physical entity: Tpx
stoichiometric coefficient: 2.0

Stoichiometry89
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 2.0

UnificationXref700
type: UnificationXref
id: 1222424
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222424

UnificationXref190
type: UnificationXref
id: 868641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868641

UnificationXref701
type: UnificationXref
id: REACT_111446
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111446.2

UnificationXref704
type: UnificationXref
id: REACT_3714
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3714.1

UnificationXref194
type: UnificationXref
id: 868622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868622

UnificationXref705
type: UnificationXref
id: 1222672
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222672

UnificationXref193
type: UnificationXref
id: REACT_27413
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27413.1

UnificationXref702
type: UnificationXref
id: CHEBI:16240
db: ChEBI

UnificationXref192
type: UnificationXref
id: 868690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868690

UnificationXref703
type: UnificationXref
id: 29408
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29408

UnificationXref191
type: UnificationXref
id: REACT_27686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27686.1

Stoichiometry56
type: Stoichiometry
physical entity: AroG-Mn++
stoichiometric coefficient: 5.0

Stoichiometry55
type: Stoichiometry
physical entity: AroG
stoichiometric coefficient: 1.0

Stoichiometry54
type: Stoichiometry
physical entity: Mn(III)
stoichiometric coefficient: 1.0

Stoichiometry53
type: Stoichiometry
physical entity: MetB holoenzyme
stoichiometric coefficient: 2.0

Stoichiometry59
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry58
type: Stoichiometry
physical entity: AroE
stoichiometric coefficient: 2.0

Stoichiometry57
type: Stoichiometry
physical entity: AroQ
stoichiometric coefficient: 12.0

UnificationXref199
type: UnificationXref
id: P9WFZ5
db: UniProt

UnificationXref196
type: UnificationXref
id: CHEBI:16551
db: ChEBI

Stoichiometry52
type: Stoichiometry
physical entity: MetB
stoichiometric coefficient: 1.0

UnificationXref195
type: UnificationXref
id: REACT_27138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27138.1

Stoichiometry51
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

UnificationXref198
type: UnificationXref
id: REACT_27821
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27821.1

Stoichiometry50
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

UnificationXref197
type: UnificationXref
id: 868614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868614

1D-myo-Inositol 1-monophosphate
type: SmallMoleculeReference
name: Inositol 1-phosphate
name: D-myo-Inositol 1-phosphate
name: L-myo-Inositol 1-phosphate
name: 1D-myo-Inositol 1-phosphate
name: 1L-myo-Inositol 1-phosphate [ChEBI:818]
name: 1L-myo-Inositol 1-phosphate
name: myo-Inositol 1-phosphate
xref: UnificationXref5

http://identifiers.org/pubmed/15886207
type: PublicationXref
id: 15886207
author: Saint-Joanis, B
author: Shepard, W
author: Alzari, PM
author: Guimarães, BG
author: Souchon, H
author: Cole, ST
author: Brosch, R
author: Honoré, N
db: Pubmed
title: Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress
source: J Biol Chem 280:25735-42
year: 2005

glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 6.3.1.13
xref: UnificationXref73
xref: UnificationXref72
xref: http://identifiers.org/pubmed/12033919
left: Adenosine 5'-triphosphate
left: L-2-amino-3-mercaptopropionic acid
left: glucosaminyl-inositol
comment: Ligation of glucosamine-inositol with the amino acid cysteine is zinc-dependent. The catalyzing enzyme MshC is a homologue of Cys-tRNA synthetase (Sareen et al, 2002)
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: diphosphate
right: desacetylmycothiol
right: 5'-Adenylic acid

Stoichiometry65
type: Stoichiometry
physical entity: BfrA dimer
stoichiometric coefficient: 12.0

desacetylmycothiol is acetylated to mycothiol using acetyl-CoA
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref86
xref: UnificationXref87
xref: http://identifiers.org/pubmed/12375100
left: desacetylmycothiol
left: Acetyl coenzyme A
comment: The final step to yield mycothiol is an acetylation using acetyl-CoA. Compounds with other acyl groups can be produced spontaneously without the MshD enzyme and can have mycothiol activity. This explains low levels of mycothiol-like activity and traces of formyl- and succinyl-Cys-GlcN-Ins in MshD null mutants (Koledin et al, 2002)
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: coenzyme A
right: mycothiol

Stoichiometry64
type: Stoichiometry
physical entity: BfrA
stoichiometric coefficient: 2.0

Mn(III)
type: SmallMoleculeReference
name: Mn(II)
name: Manganese
name: Mn2+
name: Manganese [ChEBI:18291]
xref: UnificationXref443

acetylglucosamine-inositol is deacetylated by Mca
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.5
xref: UnificationXref97
xref: UnificationXref96
xref: http://identifiers.org/pubmed/14556638
xref: http://identifiers.org/pubmed/12958317
xref: http://identifiers.org/pubmed/11092856
left: GlcNAc-Ins
left: Water
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: A small part of deacetylase activity required in the step producing glucosaminylinositol comes from the mycothiol S-conjugate amidase Mca. The hydrolaswe also needs zinc for its activity (Steffek et al, 2003).
right: glucosaminyl-inositol
right: Acetate

Stoichiometry67
type: Stoichiometry
physical entity: iron (ferric)
stoichiometric coefficient: 48.0

mycothiol is cleaved to acetylcysteine and glucosaminylinositol
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1
xref: UnificationXref101
xref: UnificationXref102
xref: http://identifiers.org/pubmed/14556638
left: Water
left: mycothiol
comment: The degradation of mycothiol proceeds through its cleavage into acetylcysteine and glucosaminylinositol which both are completely degradable further. (Steffek et al, 2003)
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-12
right: glucosaminyl-inositol

Stoichiometry66
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 48.0

Stoichiometry69
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 2.0

glucose-6-phosphate is converted to inositol-1-phosphate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 5.5.1.4
xref: http://identifiers.org/pubmed/14763976
xref: http://identifiers.org/pubmed/10448034
xref: http://identifiers.org/pubmed/12005437
xref: http://identifiers.org/pubmed/18772286
xref: UnificationXref18
xref: UnificationXref19
left: alpha-D-Glucose 6-phosphate
comment: M. tuberculosis utilizes myo-inositol-1-phosphate for mycothiol biosynthesis. This substrate comes nearly exclusively from the conversion of glucose-6-phosphate by Ino1. However, mutants devoid of Ino1 still have minimal amounts of mycothiol, so another reaction appears to provide Ins-P in small amounts, most likely the phosphorylation of uptaken inositol (Bachhawat and Mande, 1999; Mohavedzadeh et al, 2004; Newton et al, 2006; Newton et al, 2008).
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: 1L-myo-Inositol-1-phosphate

Stoichiometry68
type: Stoichiometry
physical entity: BfrA dimer
stoichiometric coefficient: 12.0

acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref36
xref: http://identifiers.org/pubmed/18390549
xref: UnificationXref35
xref: http://identifiers.org/pubmed/16940050
left: UDP-N-acetylglucosamine
left: 1L-myo-Inositol-1-phosphate
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: MshA catalyzes the transfer of acetylglucosamine from UDP-GlcNAc onto inositol-1-phosphate. From biochemical and crystal studies, there is an absolute requirement for the phosphate as substrate (Newton et al, 2006; Vetting, 2008).
right: Water
right: uridine 5'-diphosphate
right: GlcNAc-Ins-P

acetylglucosamine-inositol-phosphate is dephosphorylated
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.25
xref: UnificationXref48
xref: UnificationXref47
xref: http://identifiers.org/pubmed/16940050
xref: http://identifiers.org/pubmed/20167072
left: Water
left: GlcNAc-Ins-P
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: The enzyme to catalyze dephosphorylation of Glc-NAc-Ins-P is still unknown. Several candidate phosphatases have been characterized. The most likely is Rv3137 which was shown to be essential in M. tuberculosis (Newton et al, 2006; Movahedzadeh, 2010)
comment: Reviewed: Warner, D, 2010-11-25
right: GlcNAc-Ins
right: Phosphate

mycothiol conjugates with electrophilic xenobiotic
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref122
xref: http://identifiers.org/pubmed/17286835
xref: UnificationXref121
left: Electrophilic substrate
left: mycothiol
comment: Edited: Jassal, B, 2011-02-16
comment: Although mycothiol is able to conjugate by itself with electrophilic substances, analogously to glutathione in eukaryotes, it is possible there are specific MSH transferases for the catalysis of this reaction in cases where the substrate is more inert (Rawat and Av-Gay, 2007).
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-13
right: Electrophilic substrate-mycothiol conjugate

Stoichiometry61
type: Stoichiometry
physical entity: Riboflavin-5-phosphate
stoichiometric coefficient: 1.0

mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1
xref: http://identifiers.org/pubmed/14556638
xref: UnificationXref132
xref: UnificationXref131
left: Electrophilic substrate-mycothiol conjugate
left: Water
comment: The hydrolysis of the mycothiol S-conjugate, catalyzed by the Mca amidase, results in a so called mercapturic acid (acetylcysteine adduct) of the toxin, and glucosaminyl-inositol which is recycled to mycothiol (Steffek et al, 2003).
comment: Edited: Jassal, B, 2011-02-16
comment: Authored: Stephan, R, 2010-06-15
comment: Reviewed: Warner, D, 2010-11-25
right: glucosaminyl-inositol
right: Electrophilic substance-mercapturic acid

Stoichiometry60
type: Stoichiometry
physical entity: AroK
stoichiometric coefficient: 1.0

Stoichiometry63
type: Stoichiometry
physical entity: heme
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/21349098
type: PublicationXref
id: 21349098
author: Russell, DG
db: Pubmed
title: Mycobacterium tuberculosis and the intimate discourse of a chronic infection
source: Immunol Rev 240:252-68
year: 2011

Stoichiometry62
type: Stoichiometry
physical entity: AroC
stoichiometric coefficient: 1.0

Stoichiometry38
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 3.0

alpha,alpha'-Trehalose 6-phosphate
type: SmallMoleculeReference
name: Trehalose 6-phosphate
name: alpha,alpha'-Trehalose 6-phosphate [ChEBI:10201]
xref: UnificationXref186

Stoichiometry37
type: Stoichiometry
physical entity: Ferrodoxin (oxidized)
stoichiometric coefficient: 6.0

Stoichiometry36
type: Stoichiometry
physical entity: Fdx
stoichiometric coefficient: 1.0

Stoichiometry35
type: Stoichiometry
physical entity: (4Fe-4S)(2+)
stoichiometric coefficient: 1.0

Stoichiometry34
type: Stoichiometry
physical entity: (4Fe-4S)(1+)
stoichiometric coefficient: 1.0

F420-6 (ox.) [ChEBI:1130536]
type: SmallMoleculeReference
name: F420-6 (ox.)
xref: UnificationXref565

Stoichiometry33
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 6.0

Stoichiometry32
type: Stoichiometry
physical entity: Ferrodoxin (reduced)
stoichiometric coefficient: 6.0

Stoichiometry31
type: Stoichiometry
physical entity: Fdx
stoichiometric coefficient: 1.0

Stoichiometry30
type: Stoichiometry
physical entity: (4Fe-4S)(1+)
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/17286835
type: PublicationXref
id: 17286835
author: Av-Gay, Y
author: Rawat, M
db: Pubmed
title: Mycothiol-dependent proteins in actinomycetes
source: FEMS Microbiol Rev 31:278-92
year: 2007

http://identifiers.org/pubmed/11092856
type: PublicationXref
id: 11092856
author: Av-Gay, Y
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis
source: J Bacteriol 182:6958-63
year: 2000

alpha-oxo-n-butyric acid
type: SmallMoleculeReference
name: 2-oxobutanoic acid
name: 2-KETOBUTYRIC ACID
name: 2-Oxobutyric acid
name: 2-Ketobutyric acid
name: 3-methyl pyruvic acid
name: alpha-ketobutyric acid
name: 2-oxobutanoic acid [ChEBI:30831]
xref: UnificationXref418

Stoichiometry39
type: Stoichiometry
physical entity: siroheme
stoichiometric coefficient: 1.0

Stoichiometry47
type: Stoichiometry
physical entity: CysM
stoichiometric coefficient: 1.0

Stoichiometry46
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Stoichiometry49
type: Stoichiometry
physical entity: Mec+
stoichiometric coefficient: 1.0

Stoichiometry48
type: Stoichiometry
physical entity: CysM holoenzyme
stoichiometric coefficient: 2.0

Stoichiometry43
type: Stoichiometry
physical entity: CysK1
stoichiometric coefficient: 2.0

Stoichiometry42
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Stoichiometry45
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Stoichiometry44
type: Stoichiometry
physical entity: CysK2
stoichiometric coefficient: 1.0

ChEBI:52442 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
type: SmallMoleculeReference
name: GlcNAc-(alpha1,1)-1D-Ins
name: GlcNAc-Ins
name: 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
xref: UnificationXref37

http://identifiers.org/pubmed/19261352
type: PublicationXref
id: 19261352
author: de Chastellier, C
db: Pubmed
title: The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages
source: Immunobiology 214:526-42
year: 2009

ChEBI:52443 GlcNAc-(alpha1,1)-1D-Ins-3-P
type: SmallMoleculeReference
name: 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol-3-phosphate
name: GlcNAc-(alpha1,1)-1D-Ins-3-P
xref: UnificationXref23

Stoichiometry41
type: Stoichiometry
physical entity: Sir
stoichiometric coefficient: 1.0

Stoichiometry40
type: Stoichiometry
physical entity: Iron Sulphur Cluster
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/18772286
type: PublicationXref
id: 18772286
author: Buchmeier, N
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria
source: Microbiol Mol Biol Rev 72:471-94
year: 2008

http://identifiers.org/pubmed/1329726
type: PublicationXref
id: 1329726
author: Garbe, T
author: Moore, JD
author: Charles, IG
author: Lamb, HK
author: Hawkins, AR
author: Dougan, G
author: Servos, S
db: Pubmed
title: Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis
source: Biochem J 287:173-81
year: 1992

Sulfate [ChEBI:16189]
type: SmallMoleculeReference
name: Sulfuric acid
name: Sulfate
xref: UnificationXref237

phagocytic vesicle lumen
type: CellularLocationVocabulary
xref: UnificationXref531

Sulfur compound metabolism
type: Pathway
data source: Reactome
pathway component: Sulfate assimilation
pathway component: Sulfur amino acid metabolism
xref: http://identifiers.org/pubmed/17970225
xref: RelationshipXref61
xref: UnificationXref432
xref: UnificationXref433
pathway order: PathwayStep41
pathway order: PathwayStep29
comment: Authored: Stephan, R, 2010-06-17
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Unique small sulfur compounds, as well as unique pathways to sulfur amino acids are known in Mycobacteria. Sulfoglycolipids and mycothiols are an important part of the hardy pathogen nature of these organisms. Their pathways make interesting targets for drug designers (Bhave et al, 2007).
organism: Mycobacterium tuberculosis

http://identifiers.org/pubmed/12375100
type: PublicationXref
id: 12375100
author: Newton, GL
author: Koledin, T
author: Fahey, RC
db: Pubmed
title: Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes
source: Arch Microbiol 178:331-7
year: 2002

http://identifiers.org/pubmed/15158675
type: PublicationXref
id: 15158675
author: Abraham, EC
author: Carroll, JD
author: Edavana, VK
author: Pastuszak, I
author: Thampi, P
author: Elbein, AD
db: Pubmed
title: Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
source: Arch Biochem Biophys 426:250-7
year: 2004

http://identifiers.org/pubmed/16008502
type: PublicationXref
id: 16008502
author: Chen, H
author: Gao, H
author: Bertozzi, CR
author: Leary, JA
author: Carroll, KS
author: Stout, CD
db: Pubmed
title: A conserved mechanism for sulfonucleotide reduction
source: PLoS Biol 3:e250
year: 2005

UniProt:P9WIK1 cysD
type: ProteinReference
name: Rv1285
name: cysD
name: MTCY373.04
xref: UnificationXref271
comment: CATALYTIC ACTIVITY: ATP + sulfate = diphosphate + adenylyl sulfate.
organism: Mycobacterium tuberculosis H37Rv

UniProt:P9WIK3 cysH
type: ProteinReference
name: cysH
name: MTCY253.29c
name: Rv2392
xref: UnificationXref314
comment: FUNCTION: Reduction of activated sulfate into sulfite (By similarity).
organism: Mycobacterium tuberculosis H37Rv

UniProt:P71746
type: ProteinReference
name: cysW
name: Rv2398c
xref: UnificationXref255
comment: FUNCTION: Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
organism: Mycobacterium tuberculosis

UniProt:P71745
type: ProteinReference
name: cysU
name: Rv2399c
name: MT2470
name: cysT
xref: UnificationXref258
comment: FUNCTION: Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
organism: Mycobacterium tuberculosis

UniProt:P71744
type: ProteinReference
name: sbp
name: Rv2400c
name: MT2471
name: subI
xref: UnificationXref241
organism: Mycobacterium tuberculosis

http://identifiers.org/pubmed/17586643
type: PublicationXref
id: 17586643
author: Basso, LA
author: Frazzon, J
author: de Mendonça, JD
author: Santos, DS
author: Ely, F
author: Palma, MS
db: Pubmed
title: Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification
source: J Bacteriol 189:6246-52
year: 2007

periplasmic space
type: CellularLocationVocabulary
xref: UnificationXref650

Tolerance by Mtb to nitric oxide produced by macrophages
type: Pathway
data source: Reactome
pathway component: Nitrosoglutathione gets cleaved to Cys(NO)-Gly
pathway component: Nitrogen dioxide is reduced to NO by F420
pathway component: MsrA/B reduces peptide-methionine S/R-sulfoxides
pathway component: Peroxynitrite is reduced to nitrite by Tpx
pathway component: Peroxynitrite is reduced by AhpE
pathway component: Peroxynitrite is reduced to nitrite by AhpC
pathway component: Nitric oxide is oxidized to nitrate
pathway component: MscR reduces nitrosomycothiol to ammonia
pathway component: Mycothiol scavenges nitrosyl
xref: http://identifiers.org/pubmed/15378046
xref: UnificationXref667
xref: UnificationXref668
xref: RelationshipXref91
pathway order: PathwayStep56
pathway order: PathwayStep57
pathway order: PathwayStep58
pathway order: PathwayStep59
pathway order: PathwayStep52
pathway order: PathwayStep53
pathway order: PathwayStep54
pathway order: PathwayStep55
pathway order: PathwayStep51
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and Mtb has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages. Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).
comment: Authored: Stephan, R, 2011-01-10
organism: Mycobacterium tuberculosis

glbN
type: ProteinReference
name: UniProt:P9WN25 glbN
name: Rv1542c
name: MTCY48.23
xref: UnificationXref576
comment: FUNCTION: Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(- 1)) rate.
organism: Mycobacterium tuberculosis H37Rv

Siroheme
type: SmallMoleculeReference
name: Siroheme [ChEBI:9166]
xref: UnificationXref337

otsA
type: ProteinReference
name: UniProt:P9WN11 otsA
name: Rv3490
xref: UnificationXref189
comment: FUNCTION: Catalyzes the transfer of glucose from a nucleoside diphosphate-glucose to glucose-6-phosphate to form trehalose-6- phosphate and nucleoside diphosphate. TPS is specific for the glucosyl acceptor but not for the glucosyl donor. Most active with the purine sugar nucleotides than the pyrimidine sugar nucleotides.
organism: Mycobacterium tuberculosis H37Rv

Cysteine synthesis from O-acetylserine
type: Pathway
data source: Reactome
pathway component: acetylation of serine
pathway component: deacetylation of O-acetylserine and sulfhydrylation using CysK1
pathway component: deacetylation of O-acetylserine and sulfhydrylation using CysK2
pathway component: sulfite results from reduction of APS
pathway component: sulfite is reduced to sulfide
xref: http://identifiers.org/pubmed/17644602
xref: http://identifiers.org/pubmed/17970225
xref: RelationshipXref51
xref: UnificationXref376
xref: UnificationXref375
pathway order: PathwayStep30
pathway order: PathwayStep31
pathway order: PathwayStep32
pathway order: PathwayStep33
pathway order: PathwayStep34
comment: Authored: Stephan, R, 2010-06-20
comment: The cysteine biosynthetic pathway using the intermediate O-acetylserine is well preserved among bacteria, and it is also the main pathway in M. tuberculosis in normal medium. It depends on a six electron reduction of sulfite to sulfide (Bhave et al, 2007; Pinto et al, 2007).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

sir
type: ProteinReference
name: UniProt:P9WJ03 sir
name: nirA
name: Rv2391
xref: UnificationXref340
comment: CATALYTIC ACTIVITY: Hydrogen sulfide + 6 oxidized ferredoxin + 3 H(2)O = sulfite + 6 reduced ferredoxin + 6 H(+).
organism: Mycobacterium tuberculosis H37Rv

UniProt:P9WMN7 moeZ
type: ProteinReference
name: moeZ
name: Rv3206c
name: moeB1
xref: UnificationXref383
comment: FUNCTION: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown.
organism: Mycobacterium tuberculosis H37Rv

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref415

peroxynitrite
type: SmallMoleculeReference
name: ChEBI:25941 peroxynitrite
xref: UnificationXref519

Mycothiol metabolism
type: Pathway
data source: Reactome
pathway component: mycothione is reduced to mycothiol
pathway component: mycothiol is oxidized to mycothione
pathway component: Mycothiol-dependent detoxification
pathway component: Mycothiol biosynthesis
pathway component: Mycothiol catabolism
xref: http://identifiers.org/pubmed/17286835
xref: http://identifiers.org/pubmed/18772286
xref: RelationshipXref16
xref: UnificationXref181
xref: UnificationXref182
pathway order: PathwayStep9
pathway order: PathwayStep7
pathway order: PathwayStep16
pathway order: PathwayStep15
pathway order: PathwayStep14
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Mycothiol (MSH), a conjugate of glucosamine, cysteine and inositol, is the Actinobacteria equivalent of glutathione. It serves as a pool for both the unstable cysteine and reduction equivalents. Mycothiol takes part in enzymatic reactions including detoxification of electrophilic compounds, inactivation of reactive oxygen and nitrogen species, reductions, and isomerizations. M. smegmatis mutants devoid of MSH are sensitive to oxidative and nitrosative stress, and antibiotics. In M. tuberculosis, however, mycothiol synthesis is essential, no null mutants are known. Results from MshD mutants, which have about 1 per cent of MSH, show the importance of mycothiol in environments where antimicrobial factors, including reactive oxygen and reactive nitrogen intermediates, are formed, such as within macrophages (Newton et al, 2008; Rawat and Av-Gay, 2007)
organism: Mycobacterium tuberculosis

fgd
type: ProteinReference
name: UniProt:P9WNE1 fgd1
name: Rv0407
name: fgd1
xref: UnificationXref789
comment: FUNCTION: Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo- oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
organism: Mycobacterium tuberculosis H37Rv

ftn
type: ProteinReference
name: bfrB
name: Rv3841
name: UniProt:P9WNE5 bfrB
xref: UnificationXref859
comment: FUNCTION: Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.
organism: Mycobacterium tuberculosis H37Rv

MTCY39.10
type: ProteinReference
name: fdxA
name: Rv2007c
name: UniProt:P9WNE7 fdxA
xref: UnificationXref324
comment: FUNCTION: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions (By similarity).
organism: Mycobacterium tuberculosis H37Rv

RelationshipXref8
type: RelationshipXref
id: 879310
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879310

RelationshipXref9
type: RelationshipXref
id: GO:0035447
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref6
type: RelationshipXref
id: 879329
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879329

RelationshipXref7
type: RelationshipXref
id: GO:0035446
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref1
type: RelationshipXref
id: GO:0004512
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref5
type: RelationshipXref
id: GO:0008934
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref4
type: RelationshipXref
id: 879249
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879249

RelationshipXref3
type: RelationshipXref
id: GO:0008375
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref2
type: RelationshipXref
id: 879307
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879307

perhydroxyl radical
type: SmallMoleculeReference
name: hydroperoxy radical
name: dioxidanyl
name: peroxyl radical
name: HO2(.)
name: hydroperoxo
name: hydrogen dioxide
name: hydroperoxyl
name: hydroperoxyl [ChEBI:25935]
name: (HO2)(.)
xref: UnificationXref532

UniProt:P95189 hisN
type: ProteinReference
name: hisN
name: Rv3137
name: impC
xref: UnificationXref44
comment: CATALYTIC ACTIVITY L-histidinol phosphate + H(2)O = L-histidinol + phosphate.PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.SIMILARITY Belongs to the inositol monophosphatase family.
organism: Mycobacterium tuberculosis

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 414

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 480

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 260

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 367

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15576367
type: PublicationXref
id: 15576367
author: Keating, L
author: Wooff, EE
author: Parish, T
author: Wheeler, PR
author: Coldham, NG
author: Hewinson, RG
author: Gordon, SV
db: Pubmed
title: Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria
source: J Biol Chem 280:8069-78
year: 2005

mshA
type: ProteinReference
name: UniProt:P9WMY7 mshA
name: MTCY20G9.12
name: Rv0486
xref: UnificationXref32
comment: FUNCTION: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref689
type: UnificationXref
id: P9WGN9
db: UniProt

UnificationXref688
type: UnificationXref
id: REACT_122862
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122862.1

UnificationXref687
type: UnificationXref
id: 1222436
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222436

Sulfur amino acid metabolism
type: Pathway
data source: Reactome
pathway component: Cysteine from cystathionine and vice versa
pathway component: Cysteine synthesis from O-acetylserine
pathway component: Cysteine synthesis from O-phosphoserine
xref: http://identifiers.org/pubmed/20494107
xref: RelationshipXref60
xref: UnificationXref430
xref: UnificationXref431
pathway order: PathwayStep35
pathway order: PathwayStep39
pathway order: PathwayStep40
comment: Authored: Stephan, R, 2010-06-20
comment: No cysteine auxotrophs of Mycobacterium tuberculosis are known. This suggests redundant pathways for sulfur uptake and cysteine biosynthesis. Indeed, there is full interconversion between taken up sulfate/sulfide, cysteine, and methionine via cystathionine. (Schnell and Schneider, 2010)
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

UnificationXref682
type: UnificationXref
id: REACT_123149
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123149.1

UnificationXref681
type: UnificationXref
id: 1222532
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222532

UnificationXref680
type: UnificationXref
id: P9WGN3
db: UniProt

UnificationXref686
type: UnificationXref
id: P9WGN7
db: UniProt

UnificationXref685
type: UnificationXref
id: REACT_122987
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122987.1

UnificationXref684
type: UnificationXref
id: 1222634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222634

UnificationXref683
type: UnificationXref
id: P9WGN5
db: UniProt

http://identifiers.org/pubmed/16940050
type: PublicationXref
id: 16940050
author: Bzymek, KP
author: Ta, P
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: Biochemistry of the initial steps of mycothiol biosynthesis
source: J Biol Chem 281:33910-20
year: 2006

ChEBI:61174 Mycobactin T:iron
type: SmallMoleculeReference
name: Mycobactin T:iron
xref: UnificationXref827

UnificationXref677
type: UnificationXref
id: P9WGP1
db: UniProt

UnificationXref676
type: UnificationXref
id: REACT_123577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123577.1

UnificationXref679
type: UnificationXref
id: REACT_124754
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124754.1

UnificationXref678
type: UnificationXref
id: 1222450
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222450

UnificationXref671
type: UnificationXref
id: REACT_122369
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122369.1

UnificationXref670
type: UnificationXref
id: 1222623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222623

UnificationXref673
type: UnificationXref
id: REACT_124781
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124781.1

UnificationXref672
type: UnificationXref
id: 1222527
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222527

UnificationXref675
type: UnificationXref
id: 1222457
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222457

UnificationXref674
type: UnificationXref
id: P9WGP3
db: UniProt

http://identifiers.org/pubmed/19177348
type: PublicationXref
id: 19177348
author: Jain, NK
author: Roy, I
db: Pubmed
title: Effect of trehalose on protein structure
source: Protein Sci 18:24-36
year: 2009

Rv2238c
type: ProteinReference
name: UniProt:P9WIE3 Rv2238c
name: MTCY427.19c
xref: UnificationXref605
comment: CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
organism: Mycobacterium tuberculosis H37Rv

katG
type: ProteinReference
name: UniProt:P9WIE5 katG
name: MTCY180.10
name: Rv1908c
xref: UnificationXref721
comment: FUNCTION: Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/12473104
type: PublicationXref
id: 12473104
author: Carroll, JD
author: Pan, YT
author: Elbein, AD
db: Pubmed
title: Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme
source: Eur J Biochem 269:6091-100
year: 2002

ChEBI:61168 Desferrimycobactin T
type: SmallMoleculeReference
name: Desferrimycobactin T
xref: UnificationXref803

sulfate adenylyltransferase complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry21
component: CysD
component: CysNC
xref: UnificationXref277
xref: UnificationXref278
cellular location: cytosol
comment: Reactome DB_ID: 936606

OtsA tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry13
component: OtsA
xref: UnificationXref193
xref: UnificationXref192
cellular location: cytosol
comment: Reactome DB_ID: 868690

OtsB-Mg2+
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry14
component stoichiometry: Stoichiometry15
component: OtsB
component: Mg++
xref: UnificationXref205
xref: UnificationXref206
cellular location: cytosol
comment: Reactome DB_ID: 868623

SubI--sulfate complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry17
component stoichiometry: Stoichiometry16
component: SubI
component: sulfate
xref: UnificationXref246
xref: UnificationXref247
cellular location: plasma membrane
comment: Reactome DB_ID: 936589

sulfate ABC transporter
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry18
component stoichiometry: Stoichiometry19
component stoichiometry: Stoichiometry20
component: CysT
component: CysW
component: CysA
xref: UnificationXref264
xref: UnificationXref265
cellular location: plasma membrane
comment: Reactome DB_ID: 936707

Ino1-Zn2+
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry1
component stoichiometry: Stoichiometry2
component: Zn(II)
component: Ino1
xref: UnificationXref16
xref: UnificationXref15
cellular location: cytosol
comment: Reactome DB_ID: 879258

MshC-Zn2+
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry4
component stoichiometry: Stoichiometry3
component: Zn(II)
component: MshC
xref: UnificationXref71
xref: UnificationXref70
cellular location: cytosol
comment: Reactome DB_ID: 879241

Mca-Zn++
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry5
component stoichiometry: Stoichiometry6
component: Zn(II)
component: Mca
xref: UnificationXref95
xref: UnificationXref94
cellular location: cytosol
comment: Reactome DB_ID: 879260

MscR:Zn2+
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry8
component stoichiometry: Stoichiometry7
component: Zn(II)
component: MscR
xref: UnificationXref151
xref: UnificationXref152
cellular location: cytosol
comment: Reactome DB_ID: 1222283

UniProt:Q79FV4 cysK2
type: ProteinReference
name: cysK2
name: Rv0848
xref: UnificationXref368
comment: MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the cysteine synthase/cystathionine beta-synthase family.
organism: Mycobacterium tuberculosis

http://identifiers.org/pubmed/12809551
type: PublicationXref
id: 12809551
author: Blanchard, JS
author: Zheng, R
author: Steenkamp, DJ
author: Vogt, RN
db: Pubmed
title: The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase
source: Biochem J 374:657-66
year: 2003

UnificationXref699
type: UnificationXref
id: CHEBI:18421
db: ChEBI

UnificationXref698
type: UnificationXref
id: REACT_121173
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121173.3

UnificationXref695
type: UnificationXref
id: 1222323
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222323

UnificationXref694
type: UnificationXref
id: REACT_122704
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122704.1

UnificationXref697
type: UnificationXref
id: 1222523
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222523

UnificationXref696
type: UnificationXref
id: REACT_122152
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122152.1

UnificationXref691
type: UnificationXref
id: REACT_121637
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121637.1

UnificationXref690
type: UnificationXref
id: 1222653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222653

UnificationXref693
type: UnificationXref
id: 1222746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222746

UnificationXref692
type: UnificationXref
id: P9WGP5
db: UniProt

UnificationXref495
type: UnificationXref
id: 964900
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964900

UnificationXref494
type: UnificationXref
id: CHEBI:57701
db: ChEBI

UnificationXref493
type: UnificationXref
id: REACT_27301
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27301.1

alpha-D-Glucose 6-phosphate
type: SmallMoleculeReference
name: alpha-D-Glucose 6-phosphate [ChEBI:17665]
xref: UnificationXref2

UnificationXref492
type: UnificationXref
id: 964939
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964939

UnificationXref499
type: UnificationXref
id: REACT_27456
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27456.1

UnificationXref498
type: UnificationXref
id: 964880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964880

UnificationXref497
type: UnificationXref
id: P9WPY5
db: UniProt

UnificationXref496
type: UnificationXref
id: REACT_27363
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27363.1

http://identifiers.org/pubmed/20167072
type: PublicationXref
id: 20167072
author: Stoker, NG
author: Parish, T
author: Movahedzadeh, F
author: Wheeler, PR
author: Av-Gay, Y
author: Daffe, M
author: Dinadayala, P
db: Pubmed
title: Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis
source: BMC Microbiol 10:50
year: 2010

http://identifiers.org/pubmed/18461140
type: PublicationXref
id: 18461140
author: Kumar, S
author: Hasnain, SE
author: Ehtesham, NZ
author: Tyagi, AK
author: Rathore, SS
author: Farhana, A
author: Ghosh, PC
db: Pubmed
title: Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron
source: PLoS One 3:e2087
year: 2008

UnificationXref851
type: UnificationXref
id: 1562627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562627

UnificationXref850
type: UnificationXref
id: REACT_5725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5725.2

UnificationXref855
type: UnificationXref
id: 1562615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562615

UnificationXref854
type: UnificationXref
id: REACT_123779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123779.1

UnificationXref853
type: UnificationXref
id: 1562633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562633

UnificationXref852
type: UnificationXref
id: REACT_123042
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123042.1

UnificationXref859
type: UnificationXref
id: P9WNE5
db: UniProt

UnificationXref858
type: UnificationXref
id: REACT_120963
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120963.3

UnificationXref857
type: UnificationXref
id: 1562604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562604

UnificationXref856
type: UnificationXref
id: REACT_125193
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125193.1

UDP
type: SmallMoleculeReference
name: uridine 5'-diphosphate
name: uridine 5'-diphosphate [ChEBI:17659]
xref: UnificationXref29

UnificationXref860
type: UnificationXref
id: 1562631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562631

UnificationXref862
type: UnificationXref
id: 1562623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562623

UnificationXref861
type: UnificationXref
id: REACT_123262
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123262.1

UnificationXref864
type: UnificationXref
id: 1562601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562601

UnificationXref863
type: UnificationXref
id: REACT_124033
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124033.1

UnificationXref866
type: UnificationXref
id: 1562603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562603

UnificationXref865
type: UnificationXref
id: REACT_125633
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125633.1

UnificationXref868
type: UnificationXref
id: 1222449
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222449

UnificationXref867
type: UnificationXref
id: REACT_120810
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120810.3

UnificationXref869
type: UnificationXref
id: REACT_121118
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121118.3

RelationshipXref108
type: RelationshipXref
id: 1222335
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222335

UnificationXref477
type: UnificationXref
id: P95001
db: UniProt

RelationshipXref107
type: RelationshipXref
id: GO:0004148
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref476
type: UnificationXref
id: REACT_27352
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27352.2

RelationshipXref106
type: RelationshipXref
id: 1222698
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222698

UnificationXref475
type: UnificationXref
id: 964932
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964932

RelationshipXref105
type: RelationshipXref
id: 1222602
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222602

UnificationXref474
type: UnificationXref
id: CHEBI:16119
db: ChEBI

UnificationXref473
type: UnificationXref
id: REACT_27221
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27221.1

UnificationXref472
type: UnificationXref
id: 964851
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964851

UnificationXref838
type: UnificationXref
id: 1222394
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222394

UnificationXref471
type: UnificationXref
id: REACT_27728
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27728.1

UnificationXref839
type: UnificationXref
id: REACT_123752
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123752.1

RelationshipXref109
type: RelationshipXref
id: 1222743
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222743

UnificationXref470
type: UnificationXref
id: 964852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964852

UnificationXref479
type: UnificationXref
id: REACT_27408
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27408.1

UnificationXref478
type: UnificationXref
id: 964887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964887

UnificationXref837
type: UnificationXref
id: P9WQJ7
db: UniProt

UnificationXref836
type: UnificationXref
id: REACT_123451
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123451.1

RelationshipXref100
type: RelationshipXref
id: 1222563
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222563

UnificationXref480
type: UnificationXref
id: 964862
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964862

UnificationXref835
type: UnificationXref
id: 1222596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222596

UnificationXref834
type: UnificationXref
id: P9WQJ9
db: UniProt

UnificationXref833
type: UnificationXref
id: REACT_123376
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123376.1

RelationshipXref103
type: RelationshipXref
id: GO:0052059
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

UnificationXref832
type: UnificationXref
id: 1222331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222331

RelationshipXref104
type: RelationshipXref
id: GO:0015036
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref831
type: UnificationXref
id: REACT_120837
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120837.2

RelationshipXref101
type: RelationshipXref
id: GO:0008785
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref830
type: UnificationXref
id: 1222325
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222325

RelationshipXref102
type: RelationshipXref
id: 1222643
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222643

UnificationXref486
type: UnificationXref
id: REACT_27334
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27334.2

UnificationXref485
type: UnificationXref
id: 964859
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964859

UnificationXref488
type: UnificationXref
id: 964918
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964918

UnificationXref487
type: UnificationXref
id: P9WPY3
db: UniProt

UnificationXref849
type: UnificationXref
id: 111736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111736

UnificationXref482
type: UnificationXref
id: 964842
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964842

UnificationXref481
type: UnificationXref
id: REACT_27893
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27893.1

UnificationXref484
type: UnificationXref
id: CHEBI:17052
db: ChEBI

UnificationXref483
type: UnificationXref
id: REACT_27289
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27289.1

UnificationXref489
type: UnificationXref
id: REACT_27816
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27816.1

Chorismate via Shikimate Pathway
type: Pathway
data source: Reactome
pathway component: DHQ from DAHP dephosphorylation
pathway component: DHAP from Ery4P and PEP
pathway component: Shikimate results from hydration of DHS
pathway component: Dehydratation of DHQ yields DHS
pathway component: EPSP from shikimate 3-phosphate
pathway component: Phosphorylation of shikimate
pathway component: Dephosphorylation of EPSP yields chorismate
xref: RelationshipXref76
xref: http://identifiers.org/pubmed/15012217
xref: UnificationXref516
xref: UnificationXref515
pathway order: PathwayStep43
pathway order: PathwayStep44
pathway order: PathwayStep47
pathway order: PathwayStep48
pathway order: PathwayStep45
pathway order: PathwayStep46
pathway order: PathwayStep49
comment: Authored: Stephan, R, 2010-09-13
comment: The shikimate pathway leads to the biosynthesis of chorismate, which, in mycobacteria, is a precursor of aromatic amino acids, naphthoquinones, menaquinones and siderophores. The enzymes of this pathway are attractive pharmaceutical targets, as the pathway is absent from mammals, and there are no redundancies in it (Herrmann and Weaver, 1999).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

RelationshipXref12
type: RelationshipXref
id: 879287
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879287

RelationshipXref11
type: RelationshipXref
id: GO:0016810
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref840
type: UnificationXref
id: P9WL31
db: UniProt

RelationshipXref10
type: RelationshipXref
id: 879254
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879254

alpha,alpha-Trehalose
type: SmallMoleculeReference
name: alpha,alpha-Trehalose [ChEBI:10202]
name: Trehalose
name: alpha,alpha'-Trehalose
xref: UnificationXref196

http://identifiers.org/pubmed/15901732
type: PublicationXref
id: 15901732
author: Krämer, R
author: Strelkov, S
author: Meniche, X
author: Wolf, A
author: Daffe, M
author: Morbach, S
author: Schomburg, D
author: Tropis, M
author: Chami, M
author: Gebhardt, H
db: Pubmed
title: The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae
source: J Biol Chem 280:26573-85
year: 2005

UnificationXref846
type: UnificationXref
id: REACT_120927
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120927.3

UnificationXref845
type: UnificationXref
id: 1222597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222597

RelationshipXref19
type: RelationshipXref
id: GO:0010127
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

UnificationXref848
type: UnificationXref
id: REACT_121393
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121393.4

RelationshipXref18
type: RelationshipXref
id: 879242
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879242

UnificationXref490
type: UnificationXref
id: 964917
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964917

UnificationXref847
type: UnificationXref
id: 1222399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222399

RelationshipXref17
type: RelationshipXref
id: GO:0050607
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref491
type: UnificationXref
id: REACT_27546
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27546.1

UnificationXref842
type: UnificationXref
id: REACT_121752
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121752.1

RelationshipXref16
type: RelationshipXref
id: GO:0010126
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

http://identifiers.org/pubmed/11481433
type: PublicationXref
id: 11481433
author: St John, G
author: Tempst, P
author: Ruan, J
author: Erdjument-Bromage, H
author: Brot, N
author: Weissbach, H
author: Nathan, C
db: Pubmed
title: Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates
source: Proc Natl Acad Sci U S A 98:9901-6
year: 2001

UnificationXref841
type: UnificationXref
id: 1222389
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222389

RelationshipXref15
type: RelationshipXref
id: 879240
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879240

UnificationXref844
type: UnificationXref
id: REACT_125392
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125392.1

RelationshipXref14
type: RelationshipXref
id: GO:0016811
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref843
type: UnificationXref
id: 1222486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222486

RelationshipXref13
type: RelationshipXref
id: GO:0010125
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

Protoheme
type: SmallMoleculeReference
name: Ferroheme
name: Heme
name: Haem
name: Heme [ChEBI:17627]
xref: UnificationXref539

UnificationXref458
type: UnificationXref
id: REACT_27970
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27970.3

UnificationXref459
type: UnificationXref
id: P9WPX9
db: UniProt

UnificationXref456
type: UnificationXref
id: CHEBI:32364
db: ChEBI

UnificationXref457
type: UnificationXref
id: 964921
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964921

http://identifiers.org/pubmed/17012768
type: PublicationXref
id: 17012768
author: Jaeger, T
author: Flohé, L
db: Pubmed
title: The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs
source: Biofactors 27:109-20
year: 2006

UnificationXref450
type: UnificationXref
id: REACT_27948
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27948.1

UnificationXref451
type: UnificationXref
id: 964878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964878

FMN [ChEBI:17621]
type: SmallMoleculeReference
name: FMN
name: Riboflavin-5-phosphate
name: Flavin mononucleotide
xref: UnificationXref505

UnificationXref454
type: UnificationXref
id: REACT_27267
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27267.1

UnificationXref455
type: UnificationXref
id: GO:0009532
db: GENE ONTOLOGY

UnificationXref452
type: UnificationXref
id: REACT_27538
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27538.1

UnificationXref453
type: UnificationXref
id: 964912
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964912

UnificationXref467
type: UnificationXref
id: P9WPX7
db: UniProt

UnificationXref468
type: UnificationXref
id: 964891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964891

UnificationXref469
type: UnificationXref
id: REACT_27764
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27764.1

UnificationXref460
type: UnificationXref
id: 964848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964848

UnificationXref461
type: UnificationXref
id: REACT_27487
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27487.1

UnificationXref462
type: UnificationXref
id: 964914
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964914

UnificationXref463
type: UnificationXref
id: REACT_27251
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27251.1

MTCY190.26
type: ProteinReference
name: sucB
name: dlaT
name: UniProt:P9WIS7 dlaT
name: Rv2215
xref: UnificationXref749
comment: FUNCTION: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
organism: Mycobacterium tuberculosis H37Rv

UnificationXref464
type: UnificationXref
id: CHEBI:16630
db: ChEBI

UnificationXref465
type: UnificationXref
id: 964941
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964941

UnificationXref466
type: UnificationXref
id: REACT_27527
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27527.2

UnificationXref438
type: UnificationXref
id: 29492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29492

http://identifiers.org/pubmed/21494619
type: PublicationXref
id: 21494619
author: Gupta, RK
author: Tyagi, AK
author: Sauter, NK
author: Nangpal, P
author: Gupta, V
author: Khare, G
db: Pubmed
title: Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity
source: PLoS One 6:e18570
year: 2011

UnificationXref439
type: UnificationXref
id: REACT_5622
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5622.2

UnificationXref436
type: UnificationXref
id: REACT_2886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2886.2

UnificationXref437
type: UnificationXref
id: CHEBI:18021
db: ChEBI

Trehalose biosynthesis
type: Pathway
data source: Reactome
pathway component: 1,4-alpha-glucan is converted to glucanotrehalose
pathway component: Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose
pathway component: Trehalose-6-phosphate is hydrolyzed to trehalose
pathway component: Maltose is converted to trehalose
pathway component: Glucose is transferred from UDP-glucose onto glucose-6-phosphate
xref: UnificationXref235
xref: UnificationXref234
xref: http://identifiers.org/pubmed/10658666
xref: RelationshipXref32
xref: http://identifiers.org/pubmed/15901732
xref: http://identifiers.org/pubmed/15703182
xref: http://identifiers.org/pubmed/19177348
xref: http://identifiers.org/pubmed/12626396
pathway order: PathwayStep19
pathway order: PathwayStep18
pathway order: PathwayStep22
pathway order: PathwayStep21
pathway order: PathwayStep20
comment: The non-reducing disaccharide trehalose is found in insects, plants, and microorganisms. In bacteria, it is a storage energy source and is essential for the survival of many stress conditions. In mycobacteria, trehalose is also part of the cell wall and of the 'cord factor' which is important for entry into the host (Elbein et al, 2003; Tropis et al, 2005; Jain & Roy, 2009) M. tuberculosis has three ways to synthesize trehalose: from UDP-glucose and glucose phosphate (the OtsAB pathway), from maltose (the TreS pathway), and from glycogen (TreYZ pathway). The OtsAB pathway was shown to be essential for the organism. It is not known, however, whether or not the essentiality of trehalose for the mycobacterial growth is directly connected to the biosynthesis of cell wall mycolates (De Smet et al, 2000; Murphy et al, 2005)
comment: Authored: Stephan, R, 2010-05-29
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

UnificationXref434
type: UnificationXref
id: CHEBI:16897
db: ChEBI

Cell redox homeostasis
type: Pathway
data source: Reactome
pathway component: TrxA/B1 reactivates Tpx
pathway component: Fgd1 reactivates F420
pathway component: TrxA reactivates AhpC
pathway component: TrxB reactivates TrxA
pathway component: DlaT reactivates AhpD
pathway component: Lpd reactivates dlaT
pathway component: AhpD reactivates AhpC
xref: RelationshipXref115
xref: UnificationXref794
xref: UnificationXref795
xref: http://identifiers.org/pubmed/17012768
xref: http://identifiers.org/pubmed/21270886
pathway order: PathwayStep69
pathway order: PathwayStep73
pathway order: PathwayStep72
pathway order: PathwayStep71
pathway order: PathwayStep75
pathway order: PathwayStep70
pathway order: PathwayStep74
comment: The most important response of Mtb to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
organism: Mycobacterium tuberculosis

http://identifiers.org/pubmed/12368430
type: PublicationXref
id: 12368430
author: Pryor, MJ
author: Medigue, C
author: Cole, ST
author: Camus, JC
db: Pubmed
title: Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
source: Microbiology 148:2967-73
year: 2002

UnificationXref435
type: UnificationXref
id: 29878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29878

UnificationXref432
type: UnificationXref
id: 936621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936621

UnificationXref433
type: UnificationXref
id: REACT_27247
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27247.1

UnificationXref430
type: UnificationXref
id: 937250
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937250

UnificationXref431
type: UnificationXref
id: REACT_27187
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27187.1

UnificationXref870
type: UnificationXref
id: 1222499
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222499

UnificationXref871
type: UnificationXref
id: REACT_121042
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121042.3

http://identifiers.org/pubmed/12675804
type: PublicationXref
id: 12675804
author: Jacobs WR, Jr
author: Belisle, JT
author: Chan, J
author: Braunstein, M
author: Espinosa, BJ
db: Pubmed
title: SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis
source: Mol Microbiol 48:453-64
year: 2003

UnificationXref449
type: UnificationXref
id: 964931
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964931

UnificationXref445
type: UnificationXref
id: REACT_4937
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4937.2

UnificationXref446
type: UnificationXref
id: O53512
db: UniProt

UnificationXref447
type: UnificationXref
id: 964864
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964864

UnificationXref448
type: UnificationXref
id: REACT_27666
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27666.1

UnificationXref441
type: UnificationXref
id: 964909
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964909

UnificationXref442
type: UnificationXref
id: REACT_27398
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27398.1

UnificationXref443
type: UnificationXref
id: CHEBI:18291
db: ChEBI

UnificationXref444
type: UnificationXref
id: 29418
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29418

UnificationXref440
type: UnificationXref
id: CHEBI:58394
db: ChEBI

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref40

Tolerance of reactive oxygen produced by macrophages
type: Pathway
data source: Reactome
pathway component: SodB gets secreted
pathway component: SodB reduces superoxide to H2O2
pathway component: SodC reduces superoxide to H2O2
pathway component: KatG reduces H2O2
pathway component: AhpC reduces H2O2
pathway component: AhpC reduces peroxidated lipids
pathway component: H2O2 gets scavenged by unsaturated lipid
xref: http://identifiers.org/pubmed/11970850
xref: UnificationXref738
xref: UnificationXref739
xref: RelationshipXref103
pathway order: PathwayStep67
pathway order: PathwayStep65
pathway order: PathwayStep66
pathway order: PathwayStep63
pathway order: PathwayStep64
pathway order: PathwayStep62
pathway order: PathwayStep61
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The expression of AhpC in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in Mtb appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002).
comment: Authored: Stephan, R, 2011-01-10
organism: Mycobacterium tuberculosis

SequenceSite68
type: SequenceSite
position status: EQUAL
sequence position: 323

3-Dehydroquinate
type: SmallMolecule
entity reference: (-)-3-dehydroquinate
data source: Reactome
xref: UnificationXref458
xref: UnificationXref457
cellular location: plastid stroma
comment: Reactome DB_ID: 964921
display name: 3DHQ

SequenceSite67
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite69
type: SequenceSite
position status: EQUAL
sequence position: 26

SequenceSite64
type: SequenceSite
position status: EQUAL
sequence position: 93

EPSP(4-)
type: SmallMolecule
entity reference: 5-enolpyruvyl shikimate-3-phosphate
data source: Reactome
xref: UnificationXref495
xref: UnificationXref496
cellular location: cytosol
comment: Reactome DB_ID: 964900

SequenceSite63
type: SequenceSite
position status: EQUAL
sequence position: 392

Shikimate 3-phosphate
type: SmallMolecule
entity reference: Shikimate 3-phosphate
data source: Reactome
xref: UnificationXref486
xref: UnificationXref485
cellular location: cytosol
comment: Reactome DB_ID: 964859
display name: SKMP

Response of Mtb to phagocytosis
type: Pathway
data source: Reactome
pathway component: Tolerance by Mtb to nitric oxide produced by macrophages
pathway component: Tolerance of reactive oxygen produced by macrophages
pathway component: Cell redox homeostasis
pathway component: Mtb iron assimilation by chelation
xref: RelationshipXref124
xref: http://identifiers.org/pubmed/21349098
xref: UnificationXref870
xref: http://identifiers.org/pubmed/19261352
xref: UnificationXref871
xref: http://identifiers.org/pubmed/19369951
xref: http://identifiers.org/pubmed/20466922
pathway order: PathwayStep68
pathway order: PathwayStep60
pathway order: PathwayStep76
pathway order: PathwayStep85
comment: Mtb encounters a vastly changed environment, soon after it gets internalized by macrophages. The compartment it resides in, the phagosome, is acidified and devoid of important metal ions. It is flooded with reactive oxygen and nitrogen species. And steps will be soon taken by the macrophage to "mature" the phagosome with all kinds of lysosomal digestive enzymes. However, unlike most other bacteria species Mtb. has evolved solutions to each of these threats and, after making sure these are installed, it soon will enter a dormant state (de Chastellier, 2009; Flannagan et al, 2009). A combination of the host defense and the response of the infecting bacillus (active and passive) ensure suppression of bacterial metabolic activity and replication, resulting in a non-replicating state (Russell 2011, Russell et al. 2010).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
organism: Mycobacterium tuberculosis

SequenceSite66
type: SequenceSite
position status: EQUAL
sequence position: 93

Shikimate
type: SmallMolecule
entity reference: Shikimate
data source: Reactome
xref: UnificationXref476
xref: UnificationXref475
cellular location: cytosol
comment: Reactome DB_ID: 964932
display name: SKM

SequenceSite65
type: SequenceSite
position status: EQUAL
sequence position: 2

3-Dehydroshikimate
type: SmallMolecule
entity reference: 3-Dehydroshikimate
data source: Reactome
xref: UnificationXref465
xref: UnificationXref466
cellular location: cytosol
comment: Reactome DB_ID: 964941
display name: 3DHSK

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 2

Nitrite
type: SmallMolecule
entity reference: Nitrite [ChEBI:7585]
data source: Reactome
xref: UnificationXref525
xref: UnificationXref526
cellular location: cytosol
comment: Reactome DB_ID: 1222379

Peroxynitrite
type: SmallMolecule
entity reference: peroxynitrite
data source: Reactome
xref: UnificationXref521
xref: UnificationXref520
cellular location: cytosol
comment: Reactome DB_ID: 1222481
display name: ONOO-

SequenceSite62
type: SequenceSite
position status: EQUAL
sequence position: 1

Riboflavin-5-phosphate
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Reactome
name: Flavin mononucleotide
xref: UnificationXref506
xref: UnificationXref507
cellular location: cytosol
comment: Reactome DB_ID: 73524
display name: FMN

SequenceSite61
type: SequenceSite
position status: EQUAL
sequence position: 93

Chorismate
type: SmallMolecule
entity reference: Chorismate [ChEBI:3677]
data source: Reactome
xref: UnificationXref504
xref: UnificationXref503
cellular location: plastid stroma
comment: Reactome DB_ID: 964856
display name: CRSM

hydroperoxyl
type: SmallMolecule
entity reference: perhydroxyl radical
data source: Reactome
xref: UnificationXref534
xref: UnificationXref533
cellular location: phagocytic vesicle lumen
comment: Reactome DB_ID: 1470070

http://identifiers.org/pubmed/11929522
type: PublicationXref
id: 11929522
author: Michell, SL
author: Jacobs WR, Jr
author: Wooff, E
author: Wheeler, PR
author: Bardarov, S
author: Hewinson, RG
author: Chambers, MA
author: Gordon, SV
db: Pubmed
title: Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo
source: Mol Microbiol 43:653-63
year: 2002

http://identifiers.org/pubmed/12033919
type: PublicationXref
id: 12033919
author: Sareen, D
author: Steffek, M
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases
source: Biochemistry 41:6885-90
year: 2002

Mycobacterium tuberculosis
type: BioSource
xref: UnificationXref43

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 93

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 93

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 2

heme
type: SmallMolecule
entity reference: Protoheme
data source: Reactome
xref: UnificationXref541
xref: UnificationXref540
cellular location: plasma membrane
comment: Reactome DB_ID: 917919

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 372

hydroperoxyl
type: SmallMolecule
entity reference: perhydroxyl radical
data source: Reactome
xref: UnificationXref536
xref: UnificationXref535
cellular location: cytosol
comment: Reactome DB_ID: 1475048

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 1

iron (ferric)
type: SmallMolecule
entity reference: Fe(3+)
data source: Reactome
xref: UnificationXref554
xref: UnificationXref553
cellular location: plasma membrane
comment: Reactome DB_ID: 1222433
display name: Fe3+

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 310

Fe(III)
type: SmallMolecule
entity reference: iron (ferrous)
data source: Reactome
name: iron (ferrous)
name: Fe3+
name: Fe(II)
name: Iron
name: Fe++
xref: UnificationXref550
xref: UnificationXref551
cellular location: cytosol
comment: Reactome DB_ID: 71067
display name: Fe2+

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 1

nitrogen dioxide
type: SmallMolecule
entity reference: Stickstoffdioxid
data source: Reactome
xref: UnificationXref564
xref: UnificationXref563
cellular location: cytosol
comment: Reactome DB_ID: 1500793
display name: NO2

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 229

cofactor F420 (red.)
type: SmallMolecule
entity reference: F420-6 (red.)
data source: Reactome
xref: UnificationXref561
xref: UnificationXref560
cellular location: cytosol
comment: Reactome DB_ID: 1500819

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 1

NO
type: SmallMolecule
entity reference: Nitrogen monoxide
data source: Reactome
xref: UnificationXref570
xref: UnificationXref569
cellular location: cytosol
comment: Reactome DB_ID: 202124

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 555

cofactor F420 (ox.)
type: SmallMolecule
entity reference: F420-6 (ox.) [ChEBI:1130536]
data source: Reactome
xref: UnificationXref567
xref: UnificationXref566
cellular location: cytosol
comment: Reactome DB_ID: 1130536

heme (ferrous)
type: SmallMolecule
entity reference: Protoheme
data source: Reactome
xref: UnificationXref580
xref: UnificationXref579
cellular location: cytosol
comment: Reactome DB_ID: 71185
display name: heme

Oxygen
type: SmallMolecule
entity reference: Oxygen
data source: Reactome
xref: UnificationXref574
xref: UnificationXref575
cellular location: cytosol
comment: Reactome DB_ID: 29368
display name: O2

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 267

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 2

L-Glutamyl amino acid
type: SmallMolecule
entity reference: N(alpha)-(L-gamma-glutamyl) amino acid
data source: Reactome
xref: UnificationXref657
xref: UnificationXref658
cellular location: periplasmic space
comment: Reactome DB_ID: 1222422

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 40

S-Nitrosoglutathione
type: SmallMolecule
entity reference: S-Nitrosoglutathione
data source: Reactome
xref: UnificationXref652
xref: UnificationXref653
cellular location: periplasmic space
comment: Reactome DB_ID: 2103119
display name: GSNO

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 37

nitrosomycothiol
type: SmallMolecule
entity reference: ChEBI:59637 S-Nitrosomycothiol
data source: Reactome
xref: UnificationXref630
xref: UnificationXref631
cellular location: cytosol
comment: Reactome DB_ID: 1222312

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 116

S-Nitrosomycothiol
type: SmallMolecule
entity reference: ChEBI:59637 S-Nitrosomycothiol
data source: Reactome
xref: UnificationXref626
xref: UnificationXref627
cellular location: cytosol
comment: Reactome DB_ID: 1222631
display name: MSNO

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 254

Nitrate
type: SmallMolecule
entity reference: Nitrate
data source: Reactome
name: NO3-
xref: UnificationXref592
xref: UnificationXref593
cellular location: cytosol
comment: Reactome DB_ID: 432031
display name: HNO3

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 1

ferriheme
type: SmallMolecule
entity reference: ferriheme
data source: Reactome
xref: UnificationXref587
xref: UnificationXref588
cellular location: cytosol
comment: Reactome DB_ID: 917795
display name: FeHM

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 114

NO+
type: SmallMolecule
entity reference: oxidonitrogen(1+)
data source: Reactome
xref: UnificationXref585
xref: UnificationXref584
cellular location: cytosol
comment: Reactome DB_ID: 1222525

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 2

Mycothiol-dependent detoxification
type: Pathway
data source: Reactome
pathway component: formylmycothiol hydrolyzes into mycothiol and formate
pathway component: mycothiol binds formaldehyde and is dehydrogenated
pathway component: mycothiol conjugates with electrophilic xenobiotic
pathway component: mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins
xref: RelationshipXref19
xref: UnificationXref161
xref: http://identifiers.org/pubmed/17286835
xref: http://identifiers.org/pubmed/18772286
xref: UnificationXref160
pathway order: PathwayStep13
pathway order: PathwayStep12
pathway order: PathwayStep11
pathway order: PathwayStep10
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-13
comment: In analogy to glutathione, mycothiol is part of the detoxification machinery of the M. tuberculosis cell. The biotransformation of electrophilic toxins consists of creating an adduct with mycothiol, its cleavage into a "mercapturic acid" and glucosaminyl-inositol (with which mycothiol is recycled), and transport of the mercapturic acid through the membrane. The protein(s) catalyzing the transport are still unidentified. Further molecules that are changed to less dangerous entities with the help of mycothiol are formaldehyde and the nitrosyl radical (Rawat and Av-Gay, 2007; Newton et al, 2008).
organism: Mycobacterium tuberculosis

Hydrogen peroxide
type: SmallMolecule
entity reference: H2O2
data source: Reactome
xref: UnificationXref704
xref: UnificationXref703
cellular location: cytosol
comment: Reactome DB_ID: 29408
display name: H2O2

SO2.-
type: SmallMolecule
entity reference: O2.-
data source: Reactome
name: Superoxide
xref: UnificationXref700
xref: UnificationXref701
cellular location: cytosol
comment: Reactome DB_ID: 1222424
display name: O2.-

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 116

S-Nitroso-L-cysteinylglycine
type: SmallMolecule
entity reference: S-nitroso-L-cysteinylglycine
data source: Reactome
xref: UnificationXref660
xref: UnificationXref661
cellular location: periplasmic space
comment: Reactome DB_ID: 1222680

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 272

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10922044
type: PublicationXref
id: 10922044
author: Shiloh, MU
author: Nathan, C
db: Pubmed
title: Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
source: Proc Natl Acad Sci U S A 97:8841-8
year: 2000

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 353

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 283

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 614

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 1

Mtr
type: Protein
entity reference: UniProt:P9WHH3 mtr
data source: Reactome
xref: UnificationXref177
xref: UnificationXref178
feature: FragmentFeature8
cellular location: cytosol
comment: Reactome DB_ID: 879285

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 309

OtsA
type: Protein
entity reference: otsA
data source: Reactome
xref: UnificationXref190
xref: UnificationXref191
feature: FragmentFeature9
cellular location: cytosol
comment: Reactome DB_ID: 868641

Mca
type: Protein
entity reference: mca
data source: Reactome
xref: UnificationXref93
xref: UnificationXref92
feature: FragmentFeature6
cellular location: cytosol
comment: Reactome DB_ID: 879253

MscR
type: Protein
entity reference: Rv2259
data source: Reactome
xref: UnificationXref149
xref: UnificationXref150
feature: FragmentFeature7
cellular location: cytosol
comment: Reactome DB_ID: 879330

MshC
type: Protein
entity reference: Rv2130c
data source: Reactome
xref: UnificationXref69
xref: UnificationXref68
feature: FragmentFeature4
cellular location: cytosol
comment: Reactome DB_ID: 879269

MshD
type: Protein
entity reference: mshD
data source: Reactome
xref: UnificationXref85
xref: UnificationXref84
feature: FragmentFeature5
cellular location: cytosol
comment: Reactome DB_ID: 879286

http://identifiers.org/pubmed/15012217
type: PublicationXref
id: 15012217
author: Weaver, LM
author: Herrmann, KM
db: Pubmed
title: THE SHIKIMATE PATHWAY
source: Annu Rev Plant Physiol Plant Mol Biol 50:473-503
year: 1999

MshA
type: Protein
entity reference: mshA
data source: Reactome
xref: UnificationXref34
xref: UnificationXref33
feature: FragmentFeature2
cellular location: cytosol
comment: Reactome DB_ID: 879291

ImpC
type: Protein
entity reference: UniProt:P95189 hisN
data source: Reactome
xref: UnificationXref45
xref: UnificationXref46
feature: FragmentFeature3
cellular location: cytosol
comment: Reactome DB_ID: 879317

Ino1
type: Protein
entity reference: MTCY21D4.09c
data source: Reactome
xref: UnificationXref13
xref: UnificationXref14
feature: FragmentFeature1
cellular location: cytosol
comment: Reactome DB_ID: 879304

RelationshipXref124
type: RelationshipXref
id: GO:0052572
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref123
type: RelationshipXref
id: GO:0033214
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

UnificationXref810
type: UnificationXref
id: REACT_121078
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121078.3

UnificationXref811
type: UnificationXref
id: CHEBI:41609
db: ChEBI

RelationshipXref120
type: RelationshipXref
id: 1222683
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222683

UnificationXref812
type: UnificationXref
id: 1222435
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222435

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref813
type: UnificationXref
id: REACT_122546
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122546.1

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 459

RelationshipXref122
type: RelationshipXref
id: 1562606
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562606

UnificationXref814
type: UnificationXref
id: 9606
db: NCBI Taxonomy

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref121
type: RelationshipXref
id: 1562602
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562602

UnificationXref815
type: UnificationXref
id: P02788
db: UniProt

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 500

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref139

http://identifiers.org/pubmed/10512639
type: PublicationXref
id: 10512639
author: Blanchard, JS
author: Patel, MP
db: Pubmed
title: Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase
source: Biochemistry 38:11827-33
year: 1999

UnificationXref817
type: UnificationXref
id: REACT_76222
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76222.2

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref816
type: UnificationXref
id: 977171
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=977171

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 580

UnificationXref819
type: UnificationXref
id: REACT_26901
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26901.2

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref818
type: UnificationXref
id: 917943
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=917943

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 356

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 391

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 765

UnificationXref821
type: UnificationXref
id: REACT_123248
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123248.1

RelationshipXref115
type: RelationshipXref
id: GO:0045454
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

UnificationXref822
type: UnificationXref
id: CHEBI:47333
db: ChEBI

RelationshipXref114
type: RelationshipXref
id: 1500763
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500763

RelationshipXref113
type: RelationshipXref
id: GO:0016614
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

http://identifiers.org/pubmed/20586565
type: PublicationXref
id: 20586565
author: Rom, WN
author: Leibert, E
db: Pubmed
title: New drugs and regimens for treatment of TB
source: Expert Rev Anti Infect Ther 8:801-13
year: 2010

UnificationXref820
type: UnificationXref
id: 1470056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1470056

RelationshipXref112
type: RelationshipXref
id: 1243097
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1243097

UnificationXref825
type: UnificationXref
id: 1222641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222641

RelationshipXref111
type: RelationshipXref
id: 1222356
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222356

UnificationXref826
type: UnificationXref
id: REACT_121409
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121409.2

RelationshipXref110
type: RelationshipXref
id: GO:0004791
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref823
type: UnificationXref
id: 1222630
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222630

UnificationXref824
type: UnificationXref
id: REACT_122377
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122377.1

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 361

UnificationXref829
type: UnificationXref
id: REACT_125447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125447.1

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref828
type: UnificationXref
id: 1222539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222539

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 288

UnificationXref827
type: UnificationXref
id: CHEBI:61174
db: ChEBI

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref118
type: RelationshipXref
id: 1222570
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222570

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 315

RelationshipXref119
type: RelationshipXref
id: GO:0052873
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref116
type: RelationshipXref
id: GO:0015891
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref117
type: RelationshipXref
id: GO:0015343
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

ChEBI:15735 formylmycothiol
type: SmallMoleculeReference
name: formylmycothiol
xref: UnificationXref142

Shikimate
type: SmallMoleculeReference
name: Shikimic acid
name: Shikimate [ChEBI:9133]
name: 3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid
xref: UnificationXref474

http://identifiers.org/pubmed/17567578
type: PublicationXref
id: 17567578
author: Singh, M
author: Oehlmann, W
author: Schnell, R
author: Schneider, G
db: Pubmed
title: Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex
source: J Biol Chem 282:23473-81
year: 2007

UnificationXref803
type: UnificationXref
id: CHEBI:61168
db: ChEBI

GlcNAc-Ins
type: SmallMolecule
entity reference: ChEBI:52442 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
data source: Reactome
xref: UnificationXref39
xref: UnificationXref38
cellular location: cytosol
comment: Reactome DB_ID: 879332

UnificationXref804
type: UnificationXref
id: 1222609
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222609

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref41
xref: UnificationXref42
cellular location: cytosol
comment: Reactome DB_ID: 29372
display name: Pi

UnificationXref801
type: UnificationXref
id: 1222738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222738

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref27
xref: UnificationXref28
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

UnificationXref802
type: UnificationXref
id: REACT_121354
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121354.3

uridine 5'-diphosphate
type: SmallMolecule
entity reference: UDP
data source: Reactome
xref: UnificationXref30
xref: UnificationXref31
cellular location: cytosol
comment: Reactome DB_ID: 110096
display name: UDP

UDP-N-acetylglucosamine
type: SmallMolecule
entity reference: UDP-N-acetyl-D-glucosamine
data source: Reactome
name: UDP-N-acetyl-D-glucosamine
xref: UnificationXref22
xref: UnificationXref21
cellular location: cytosol
comment: Reactome DB_ID: 162756
display name: UDP-GlcNAc

UnificationXref800
type: UnificationXref
id: REACT_125575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125575.1

GlcNAc-Ins-P
type: SmallMolecule
entity reference: ChEBI:52443 GlcNAc-(alpha1,1)-1D-Ins-3-P
data source: Reactome
xref: UnificationXref24
xref: UnificationXref25
cellular location: cytosol
comment: Reactome DB_ID: 879263

1L-myo-Inositol-1-phosphate
type: SmallMolecule
entity reference: 1D-myo-Inositol 1-monophosphate
data source: Reactome
xref: UnificationXref6
xref: UnificationXref7
cellular location: cytosol
comment: Reactome DB_ID: 870330
display name: I1P

Zn(II)
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
name: Zn++
name: Zinc ion
xref: UnificationXref9
xref: UnificationXref10
cellular location: cytosol
comment: Reactome DB_ID: 29426
display name: Zn2+

alpha-D-Glucose 6-phosphate
type: SmallMolecule
entity reference: alpha-D-Glucose 6-phosphate
data source: Reactome
xref: UnificationXref3
xref: UnificationXref4
cellular location: cytosol
comment: Reactome DB_ID: 30537
display name: G6P

mca
type: ProteinReference
name: lmbE
name: MT1113
name: UniProt:O53430
name: Rv1082
xref: UnificationXref91
organism: Mycobacterium tuberculosis

UnificationXref809
type: UnificationXref
id: 1222722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222722

UnificationXref808
type: UnificationXref
id: REACT_121742
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121742.1

UnificationXref807
type: UnificationXref
id: 1222729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222729

UnificationXref806
type: UnificationXref
id: GO:0005618
db: GENE ONTOLOGY

UnificationXref805
type: UnificationXref
id: REACT_122416
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122416.1

F420-6 (red.)
type: SmallMoleculeReference
name: F420-6 (red.) [ChEBI:1500819]
xref: UnificationXref559

5'-Adenylic acid
type: SmallMoleculeReference
name: adenosine 5'-monophosphate [ChEBI:16027]
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
name: AMP
xref: UnificationXref64

Copper
type: SmallMolecule
entity reference: cupric ion
data source: Reactome
xref: UnificationXref711
xref: UnificationXref710
cellular location: cytosol
comment: Reactome DB_ID: 209799
display name: Cu2+

6-Phospho-D-glucono-1,5-lactone
type: SmallMoleculeReference
name: D-Glucono-1,5-lactone 6-phosphate [ChEBI:16938]
name: D-Glucono-1,5-lactone 6-phosphate
xref: UnificationXref786

Carboxymycobactin
type: SmallMolecule
entity reference: carboxymycobactin [ChEBI:62579]
data source: Reactome
xref: UnificationXref800
xref: UnificationXref799
cellular location: extracellular region
comment: Reactome DB_ID: 1222474

Carboxymycobactin
type: SmallMolecule
entity reference: carboxymycobactin [ChEBI:62579]
data source: Reactome
xref: UnificationXref798
xref: UnificationXref797
cellular location: cytosol
comment: Reactome DB_ID: 1222320

D-Glucono-1,5-lactone 6-phosphate
type: SmallMolecule
entity reference: 6-Phospho-D-glucono-1,5-lactone
data source: Reactome
xref: UnificationXref787
xref: UnificationXref788
cellular location: cytosol
comment: Reactome DB_ID: 31467
display name: 6-Phospho-D-glucono-1,5-lactone

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: FAD [ChEBI:16238]
data source: Reactome
xref: UnificationXref757
xref: UnificationXref758
cellular location: cytosol
comment: Reactome DB_ID: 29386
display name: FAD

iron (ferric)
type: SmallMolecule
entity reference: Fe(3+)
data source: Reactome
xref: UnificationXref819
xref: UnificationXref818
cellular location: extracellular region
comment: Reactome DB_ID: 917943
display name: Fe3+

Carbonate (2-)
type: SmallMolecule
entity reference: Carbonate(2-)
data source: Reactome
xref: UnificationXref812
xref: UnificationXref813
cellular location: extracellular region
comment: Reactome DB_ID: 1222435
display name: CO3(2-)

Mycobactin
type: SmallMolecule
entity reference: ChEBI:61168 Desferrimycobactin T
data source: Reactome
xref: UnificationXref808
xref: UnificationXref807
cellular location: cell wall
comment: Reactome DB_ID: 1222729

Mycobactin
type: SmallMolecule
entity reference: ChEBI:61168 Desferrimycobactin T
data source: Reactome
xref: UnificationXref804
xref: UnificationXref805
cellular location: cytosol
comment: Reactome DB_ID: 1222609

(4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonatooxy)heptanoate(3-)
type: SmallMoleculeReference
name: ChEBI:58394 (4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonatooxy)heptanoate(3-)
xref: UnificationXref440

ahpD
type: ProteinReference
name: MTCY428.17c
name: UniProt:P9WQB5 ahpD
name: Rv2429
xref: UnificationXref740
comment: FUNCTION: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
organism: Mycobacterium tuberculosis H37Rv

ahpC
type: ProteinReference
name: Rv2428
name: UniProt:P9WQB7 ahpC
xref: UnificationXref596
comment: FUNCTION: Together with AhpD, DlaT and Lpd, constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in detoxification of isoniazid.
organism: Mycobacterium tuberculosis H37Rv

SequenceSite90
type: SequenceSite
position status: EQUAL
sequence position: 136

http://identifiers.org/pubmed/18390549
type: PublicationXref
id: 18390549
author: Blanchard, JS
author: Frantom, PA
author: Vetting, MW
db: Pubmed
title: Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis
source: J Biol Chem 283:15834-44
year: 2008

SequenceSite91
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry122
type: Stoichiometry
physical entity: IrtA
stoichiometric coefficient: 1.0

SequenceSite92
type: SequenceSite
position status: EQUAL
sequence position: 195

Stoichiometry121
type: Stoichiometry
physical entity: Carboxymycobactin:Fe3+
stoichiometric coefficient: 2.0

SequenceSite93
type: SequenceSite
position status: EQUAL
sequence position: 174

Stoichiometry120
type: Stoichiometry
physical entity: Carbonate (2-)
stoichiometric coefficient: 2.0

SequenceSite94
type: SequenceSite
position status: EQUAL
sequence position: 176

SequenceSite95
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15184554
type: PublicationXref
id: 15184554
author: Britton, WJ
author: Triccas, JA
author: Leyh, TS
author: Tang, QX
author: Pinto, R
db: Pubmed
title: The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex
source: Microbiology 150:1681-6
year: 2004

Stoichiometry126
type: Stoichiometry
physical entity: Mycobactin:Fe3+
stoichiometric coefficient: 2.0

SequenceSite96
type: SequenceSite
position status: EQUAL
sequence position: 195

Stoichiometry125
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

SequenceSite97
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry124
type: Stoichiometry
physical entity: Rv2895c
stoichiometric coefficient: 1.0

SequenceSite98
type: SequenceSite
position status: EQUAL
sequence position: 153

Stoichiometry123
type: Stoichiometry
physical entity: IrtB
stoichiometric coefficient: 1.0

SequenceSite99
type: SequenceSite
position status: EQUAL
sequence position: 45

Stoichiometry129
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry128
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 2.0

Stoichiometry127
type: Stoichiometry
physical entity: Mycobactin
stoichiometric coefficient: 2.0

Stoichiometry131
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 4.0

Stoichiometry130
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 2.0

Stoichiometry133
type: Stoichiometry
physical entity: iron (ferric)
stoichiometric coefficient: 4.0

Stoichiometry132
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 4.0

Stoichiometry135
type: Stoichiometry
physical entity: heme (ferrous)
stoichiometric coefficient: 1.0

Stoichiometry134
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry137
type: Stoichiometry
physical entity: BfrA dimer
stoichiometric coefficient: 24.0

Stoichiometry136
type: Stoichiometry
physical entity: BfrA
stoichiometric coefficient: 2.0

Stoichiometry139
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 4.0

Stoichiometry138
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 4.0

Stoichiometry100
type: Stoichiometry
physical entity: SodB
stoichiometric coefficient: 4.0

SequenceSite70
type: SequenceSite
position status: EQUAL
sequence position: 146

SequenceSite71
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite72
type: SequenceSite
position status: EQUAL
sequence position: 388

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref332

SequenceSite73
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15917234
type: PublicationXref
id: 15917234
author: Hellman, U
author: Lindqvist, Y
author: Schnell, R
author: Schneider, G
author: Sandalova, T
db: Pubmed
title: Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site
source: J Biol Chem 280:27319-28
year: 2005

Stoichiometry108
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

SequenceSite78
type: SequenceSite
position status: EQUAL
sequence position: 147

Stoichiometry107
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 2.0

SequenceSite79
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry106
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry105
type: Stoichiometry
physical entity: SodC
stoichiometric coefficient: 2.0

Stoichiometry104
type: Stoichiometry
physical entity: Copper
stoichiometric coefficient: 2.0

SequenceSite74
type: SequenceSite
position status: EQUAL
sequence position: 462

Stoichiometry103
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

SequenceSite75
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry102
type: Stoichiometry
physical entity: SO2.-
stoichiometric coefficient: 2.0

SequenceSite76
type: SequenceSite
position status: EQUAL
sequence position: 362

Stoichiometry101
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 4.0

SequenceSite77
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry109
type: Stoichiometry
physical entity: KatG
stoichiometric coefficient: 2.0

ChEBI:33723 [4Fe-4S](1+)
type: SmallMoleculeReference
name: [4Fe-4S](1+)
xref: UnificationXref321

SequenceSite83
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite84
type: SequenceSite
position status: EQUAL
sequence position: 450

Stoichiometry111
type: Stoichiometry
physical entity: AhpD
stoichiometric coefficient: 3.0

SequenceSite81
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry110
type: Stoichiometry
physical entity: heme (ferrous)
stoichiometric coefficient: 2.0

SequenceSite82
type: SequenceSite
position status: EQUAL
sequence position: 176

SequenceSite80
type: SequenceSite
position status: EQUAL
sequence position: 269

Stoichiometry117
type: Stoichiometry
physical entity: Lactoferrin
stoichiometric coefficient: 1.0

Stoichiometry116
type: Stoichiometry
physical entity: Carbonate (2-)
stoichiometric coefficient: 2.0

Stoichiometry119
type: Stoichiometry
physical entity: Carboxymycobactin
stoichiometric coefficient: 2.0

SequenceSite89
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry118
type: Stoichiometry
physical entity: iron (ferric)
stoichiometric coefficient: 1.0

Stoichiometry113
type: Stoichiometry
physical entity: Lpd
stoichiometric coefficient: 2.0

SequenceSite87
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry112
type: Stoichiometry
physical entity: Flavin adenine dinucleotide
stoichiometric coefficient: 2.0

SequenceSite88
type: SequenceSite
position status: EQUAL
sequence position: 159

Stoichiometry115
type: Stoichiometry
physical entity: TrxB
stoichiometric coefficient: 2.0

SequenceSite85
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry114
type: Stoichiometry
physical entity: Flavin adenine dinucleotide
stoichiometric coefficient: 2.0

SequenceSite86
type: SequenceSite
position status: EQUAL
sequence position: 401

RelationshipXref76
type: RelationshipXref
id: GO:0009423
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref75
type: RelationshipXref
id: 964873
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964873

RelationshipXref78
type: RelationshipXref
id: 1222579
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222579

RelationshipXref77
type: RelationshipXref
id: GO:0004322
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref72
type: RelationshipXref
id: GO:0003866
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref71
type: RelationshipXref
id: 964940
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964940

RelationshipXref74
type: RelationshipXref
id: GO:0004107
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref73
type: RelationshipXref
id: 964849
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964849

RelationshipXref79
type: RelationshipXref
id: GO:0008941
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref543
type: UnificationXref
id: 1222562
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222562

UnificationXref542
type: UnificationXref
id: P9WPQ9
db: UniProt

mycothione
type: SmallMoleculeReference
name: ChEBI:59603 mycothione
xref: UnificationXref162

UnificationXref541
type: UnificationXref
id: REACT_26823
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26823.1

UnificationXref540
type: UnificationXref
id: 917919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=917919

http://identifiers.org/pubmed/12005437
type: PublicationXref
id: 12005437
author: Stoker, NG
author: Murray-Rust, J
author: McDonald, NQ
author: McAlister, MS
author: Movahedzadeh, F
author: Norman, RA
db: Pubmed
title: Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis
source: Structure 10:393-402
year: 2002

UnificationXref549
type: UnificationXref
id: CHEBI:18248
db: ChEBI

RelationshipXref80
type: RelationshipXref
id: 1222307
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222307

UnificationXref548
type: UnificationXref
id: REACT_201698
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201698.1

RelationshipXref81
type: RelationshipXref
id: GO:0051920
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref547
type: UnificationXref
id: 1222409
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222409

http://identifiers.org/pubmed/19369951
type: PublicationXref
id: 19369951
author: Cosio, G
author: Grinstein, S
author: Flannagan, RS
db: Pubmed
title: Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
source: Nat Rev Microbiol 7:355-66
year: 2009

UnificationXref546
type: UnificationXref
id: REACT_201458
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201458.1

UnificationXref545
type: UnificationXref
id: 1222438
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222438

UnificationXref544
type: UnificationXref
id: REACT_201118
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201118.1

RelationshipXref67
type: RelationshipXref
id: 964845
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964845

RelationshipXref66
type: RelationshipXref
id: GO:0003855
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref65
type: RelationshipXref
id: 964922
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964922

RelationshipXref64
type: RelationshipXref
id: GO:0003856
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref63
type: RelationshipXref
id: 964895
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964895

RelationshipXref62
type: RelationshipXref
id: GO:0003849
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref61
type: RelationshipXref
id: GO:0006790
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref60
type: RelationshipXref
id: GO:0000096
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref69
type: RelationshipXref
id: 964872
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964872

RelationshipXref68
type: RelationshipXref
id: GO:0004764
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref145

UnificationXref530
type: UnificationXref
id: REACT_121170
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121170.3

Oxygen
type: SmallMoleculeReference
name: O2
name: Oxygen [ChEBI:15379]
xref: UnificationXref573

UnificationXref532
type: UnificationXref
id: CHEBI:25935
db: ChEBI

UnificationXref531
type: UnificationXref
id: GO:0097013
db: GENE ONTOLOGY

UnificationXref538
type: UnificationXref
id: REACT_120718
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120718.3

RelationshipXref70
type: RelationshipXref
id: GO:0004765
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref537
type: UnificationXref
id: 1222342
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222342

UnificationXref539
type: UnificationXref
id: CHEBI:17627
db: ChEBI

UnificationXref534
type: UnificationXref
id: REACT_125665
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125665.1

UnificationXref533
type: UnificationXref
id: 1470070
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1470070

UnificationXref536
type: UnificationXref
id: REACT_122149
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122149.1

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref26

UnificationXref535
type: UnificationXref
id: 1475048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1475048

RelationshipXref94
type: RelationshipXref
id: GO:0004784
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref93
type: RelationshipXref
id: 1222636
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222636

RelationshipXref96
type: RelationshipXref
id: 1222715
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222715

RelationshipXref95
type: RelationshipXref
id: 1222303
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222303

RelationshipXref98
type: RelationshipXref
id: 1222554
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222554

RelationshipXref97
type: RelationshipXref
id: GO:0004601
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref99
type: RelationshipXref
id: GO:0004096
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref521
type: UnificationXref
id: REACT_111700
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111700.1

UnificationXref520
type: UnificationXref
id: 1222481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222481

Stoichiometry141
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

UnificationXref525
type: UnificationXref
id: 1222379
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222379

Acetate [ChEBI:15366]
type: SmallMoleculeReference
name: Acetate
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref88

Stoichiometry142
type: Stoichiometry
physical entity: BfrB
stoichiometric coefficient: 2.0

UnificationXref524
type: UnificationXref
id: CHEBI:16301
db: ChEBI

Stoichiometry143
type: Stoichiometry
physical entity: BfrB dimer
stoichiometric coefficient: 24.0

UnificationXref523
type: UnificationXref
id: REACT_122769
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122769.1

UnificationXref522
type: UnificationXref
id: 1222500
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222500

UnificationXref529
type: UnificationXref
id: 1222411
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222411

UnificationXref528
type: UnificationXref
id: REACT_125514
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125514.1

UnificationXref527
type: UnificationXref
id: 1222452
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222452

Stoichiometry140
type: Stoichiometry
physical entity: iron (ferric)
stoichiometric coefficient: 4.0

UnificationXref526
type: UnificationXref
id: REACT_125495
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125495.1

UnificationXref790
type: UnificationXref
id: 1500811
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500811

RelationshipXref85
type: RelationshipXref
id: GO:0016620
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref519
type: UnificationXref
id: CHEBI:25941
db: ChEBI

RelationshipXref84
type: RelationshipXref
id: 1222606
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222606

UnificationXref792
type: UnificationXref
id: 1500781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500781

RelationshipXref83
type: RelationshipXref
id: 1500775
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500775

UnificationXref791
type: UnificationXref
id: REACT_122854
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122854.1

RelationshipXref82
type: RelationshipXref
id: 1222367
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222367

UnificationXref794
type: UnificationXref
id: 1222541
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222541

RelationshipXref89
type: RelationshipXref
id: GO:0003840
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref793
type: UnificationXref
id: REACT_120793
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120793.3

RelationshipXref88
type: RelationshipXref
id: 1222305
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222305

UnificationXref796
type: UnificationXref
id: CHEBI:62579
db: ChEBI

RelationshipXref87
type: RelationshipXref
id: GO:0008113
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref795
type: UnificationXref
id: REACT_121394
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121394.3

RelationshipXref86
type: RelationshipXref
id: 1222575
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222575

UnificationXref798
type: UnificationXref
id: REACT_125366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125366.1

UnificationXref797
type: UnificationXref
id: 1222320
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222320

UnificationXref799
type: UnificationXref
id: 1222474
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222474

UnificationXref510
type: UnificationXref
id: REACT_27646
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27646.1

UnificationXref512
type: UnificationXref
id: REACT_27788
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27788.1

UnificationXref511
type: UnificationXref
id: 964894
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964894

UnificationXref514
type: UnificationXref
id: REACT_27204
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27204.1

UnificationXref513
type: UnificationXref
id: 964884
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964884

RelationshipXref91
type: RelationshipXref
id: GO:0052060
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

UnificationXref516
type: UnificationXref
id: REACT_27268
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27268.1

RelationshipXref92
type: RelationshipXref
id: GO:0015450
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref515
type: UnificationXref
id: 964903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964903

UnificationXref518
type: UnificationXref
id: REACT_27295
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27295.1

Acetyl coenzyme A
type: SmallMoleculeReference
name: Acetyl-CoA
name: Acetyl-CoA [ChEBI:15351]
xref: UnificationXref74

RelationshipXref90
type: RelationshipXref
id: 1222289
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222289

UnificationXref517
type: UnificationXref
id: 870392
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870392

RelationshipXref39
type: RelationshipXref
id: GO:0008441
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref35
type: RelationshipXref
id: GO:0004781
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref36
type: RelationshipXref
id: 936595
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936595

RelationshipXref37
type: RelationshipXref
id: GO:0004020
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref38
type: RelationshipXref
id: 936585
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936585

RelationshipXref31
type: RelationshipXref
id: 868635
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868635

RelationshipXref32
type: RelationshipXref
id: GO:0005992
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref33
type: RelationshipXref
id: GO:0015419
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref34
type: RelationshipXref
id: 936618
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936618

UnificationXref509
type: UnificationXref
id: 964883
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964883

RelationshipXref30
type: RelationshipXref
id: GO:0033942
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref508
type: UnificationXref
id: P9WPY1
db: UniProt

mshD
type: ProteinReference
name: Rv0819
name: UniProt:P9WJM7 mshD
xref: UnificationXref83
comment: FUNCTION: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref506
type: UnificationXref
id: 73524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524

UnificationXref507
type: UnificationXref
id: REACT_3399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3399.2

Rv2130c
type: ProteinReference
name: mshC
name: MTCY261.29c
name: cysS2
name: UniProt:P9WJM9 mshC
xref: UnificationXref67
comment: FUNCTION: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref504
type: UnificationXref
id: REACT_27559
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27559.3

UnificationXref505
type: UnificationXref
id: CHEBI:17621
db: ChEBI

UnificationXref502
type: UnificationXref
id: CHEBI:17333
db: ChEBI

S-nitroso-L-cysteinylglycine
type: SmallMoleculeReference
name: ChEBI:61088 S-nitroso-L-cysteinylglycine
xref: UnificationXref659

UnificationXref503
type: UnificationXref
id: 964856
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964856

msrA
type: ProteinReference
name: UniProt:P9WJM5 msrA
name: Rv0137c
name: MTCI5.11c
xref: UnificationXref640
comment: FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Rv1348
type: ProteinReference
name: MTCY02B10.12
name: irtA
name: UniProt:P9WQJ9 irtA
xref: UnificationXref834
comment: FUNCTION: Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref500
type: UnificationXref
id: 964886
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964886

UnificationXref501
type: UnificationXref
id: REACT_27315
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27315.1

Rv1349
type: ProteinReference
name: UniProt:P9WQJ7 irtB
name: MTCY02B10.13
name: irtB
xref: UnificationXref837
comment: FUNCTION: Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs.
organism: Mycobacterium tuberculosis H37Rv

CoA-SH
type: SmallMoleculeReference
name: Coenzyme A
name: CoA
name: CoA [ChEBI:15346]
xref: UnificationXref77

RelationshipXref28
type: RelationshipXref
id: GO:0047470
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref29
type: RelationshipXref
id: 868625
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868625

RelationshipXref26
type: RelationshipXref
id: GO:0047471
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref27
type: RelationshipXref
id: 868628
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868628

RelationshipXref24
type: RelationshipXref
id: GO:0004805
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref25
type: RelationshipXref
id: 868627
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868627

RelationshipXref22
type: RelationshipXref
id: GO:0003825
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

cysE
type: ProteinReference
name: UniProt:P95231 cysE
name: Rv2335
xref: UnificationXref353
comment: CATALYTIC ACTIVITY Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the transferase hexapeptide repeat family.
organism: Mycobacterium tuberculosis

RelationshipXref23
type: RelationshipXref
id: 868707
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868707

RelationshipXref20
type: RelationshipXref
id: GO:0050627
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref21
type: RelationshipXref
id: 879234
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879234

RelationshipXref57
type: RelationshipXref
id: 936605
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936605

RelationshipXref58
type: RelationshipXref
id: GO:0004123
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref59
type: RelationshipXref
id: 937183
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937183

MTCY253.24
type: ProteinReference
name: Rv2397c
name: cysA
name: UniProt:P9WQM1 cysA
xref: UnificationXref261
comment: FUNCTION: Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
organism: Mycobacterium tuberculosis H37Rv

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
name: Pyridoxal phosphate [ChEBI:18405]
xref: UnificationXref358

RelationshipXref50
type: RelationshipXref
id: 936693
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936693

RelationshipXref51
type: RelationshipXref
id: GO:0006535
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref52
type: RelationshipXref
id: GO:0016782
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref53
type: RelationshipXref
id: 936711
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936711

RelationshipXref54
type: RelationshipXref
id: GO:0033847
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref55
type: RelationshipXref
id: 936686
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936686

RelationshipXref56
type: RelationshipXref
id: GO:0008235
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

http://identifiers.org/pubmed/12958317
type: PublicationXref
id: 12958317
author: Arad, D
author: James, Michael N G
author: Av-Gay, Y
author: Maynes, JT
author: Garen, C
author: Newton, G
author: Fahey, RC
author: Cherney, Maia M
db: Pubmed
title: The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold
source: J Biol Chem 278:47166-70
year: 2003

RelationshipXref48
type: RelationshipXref
id: GO:0004124
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref49
type: RelationshipXref
id: 936701
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936701

RelationshipXref46
type: RelationshipXref
id: GO:0009001
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref47
type: RelationshipXref
id: 936623
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936623

http://identifiers.org/pubmed/9849904
type: PublicationXref
id: 9849904
author: Lee, FJ
author: Lin, CY
author: Tsai-Wu, JJ
author: Huang, YT
author: Lioua, GG
author: Wu, CH
db: Pubmed
title: Identification and subcellular localization of a novel Cu,Zn superoxide dismutase of Mycobacterium tuberculosis
source: FEBS Lett 439:192-6
year: 1998

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref380

RelationshipXref40
type: RelationshipXref
id: 936584
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936584

RelationshipXref41
type: RelationshipXref
id: GO:0000103
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular process

RelationshipXref44
type: RelationshipXref
id: GO:0050311
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref45
type: RelationshipXref
id: 936683
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936683

RelationshipXref42
type: RelationshipXref
id: GO:0004604
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref43
type: RelationshipXref
id: 936685
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936685

http://identifiers.org/pubmed/7972029
type: PublicationXref
id: 7972029
author: Squadrito, GL
author: Jin, X
author: Pryor, WA
db: Pubmed
title: One- and two-electron oxidations of methionine by peroxynitrite
source: Proc Natl Acad Sci U S A 91:11173-7
year: 1994

http://identifiers.org/pubmed/15615729
type: PublicationXref
id: 15615729
author: Andreassi JL, 2nd
author: Sun, M
author: Triccas, JA
author: Liu, S
author: Leyh, TS
author: Pinto, R
db: Pubmed
title: The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis
source: J Biol Chem 280:7861-6
year: 2005

SequenceSite103
type: SequenceSite
position status: EQUAL
sequence position: 165

SequenceSite102
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite105
type: SequenceSite
position status: EQUAL
sequence position: 93

SequenceSite104
type: SequenceSite
position status: EQUAL
sequence position: 60

SequenceSite107
type: SequenceSite
position status: EQUAL
sequence position: 165

SequenceSite106
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref359
type: UnificationXref
id: 29390
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29390

SequenceSite109
type: SequenceSite
position status: EQUAL
sequence position: 116

UnificationXref358
type: UnificationXref
id: CHEBI:18405
db: ChEBI

SequenceSite108
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref357
type: UnificationXref
id: REACT_27240
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27240.1

UnificationXref356
type: UnificationXref
id: 936615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936615

UnificationXref355
type: UnificationXref
id: REACT_27597
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27597.1

L-2-Amino-3-mercaptopropionic acid
type: SmallMoleculeReference
name: L-Cysteine [ChEBI:17561]
name: L-Cysteine
xref: UnificationXref55

UnificationXref354
type: UnificationXref
id: 936604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936604

UnificationXref353
type: UnificationXref
id: P95231
db: UniProt

UnificationXref352
type: UnificationXref
id: REACT_27827
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27827.2

UnificationXref351
type: UnificationXref
id: 936709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936709

UnificationXref350
type: UnificationXref
id: CHEBI:17981
db: ChEBI

SequenceSite101
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite100
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite116
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite115
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite114
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite113
type: SequenceSite
position status: EQUAL
sequence position: 136

Rv3372
type: ProteinReference
name: otsB2
name: otsB
name: UniProt:P9WFZ5 otsB
xref: UnificationXref199
comment: FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref369
type: UnificationXref
id: 936682
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936682

Mycobacterium tuberculosis biological processes
type: Pathway
data source: Reactome
pathway component: Chorismate via Shikimate Pathway
pathway component: Sulfur compound metabolism
pathway component: Trehalose biosynthesis
pathway component: Mycothiol metabolism
xref: http://identifiers.org/pubmed/20586565
xref: http://identifiers.org/pubmed/12368430
xref: UnificationXref518
xref: UnificationXref517
pathway order: PathwayStep42
pathway order: PathwayStep17
pathway order: PathwayStep23
pathway order: PathwayStep50
comment: Authored: Stephan, R, 2010-06-08
comment: Edited: Jassal, B, 2011-02-16
comment: Mycobacterium tuberculosis H37Rv is the laboratory strain most widely used of the pathogen M. tuberculosis, an actinobacterium that carries many properties of its family to the extreme. It is not only interesting as one of the top three bacterial killers, with one third of the world having a dormant infection, but also as a model for other mycobacteria regarding the processes of slow growing, dormancy, host interaction, very long chain fatty acid biosynthesis, outer cell wall assembly, as well as sulfolipid, siderophore, and mycothiol biosynthesis. M. tuberculosis produces mycolic and phthioceranic acids, the fatty acids with the longest carbon atom chains known. With up to 20 hours, it has the longest reproduction time in mycobacteria. In human macrophages in dormant state, it spends decades without reproduction. Consequently, to fully investigate these properties new methods will have to be invented. While the treatment of an M. tuberculosis infection appears standard in Western countries, it still involves six months of a regime of three antibiotics that have been known for a long time. Not unexpectedly, acceptance and adherence to such a prolonged therapy are less than desired, and this contributes to spontaneous resistance from an already higher than average mutation rate of M. tuberculosis due to replication errors. Fueled by the HIV advance, strains of this bacterium are on the rise with resistance to all used antibiotics. For this reason, M. tuberculosis is the testbed of new antibiotics development, and it offers the opportunity of many unique and essential biochemical pathways. (Camus et al. 2002; Leibert and Rom, 2010)
comment: Reviewed: Warner, D, 2010-11-25
organism: Mycobacterium tuberculosis

SequenceSite119
type: SequenceSite
position status: EQUAL
sequence position: 207

UnificationXref368
type: UnificationXref
id: Q79FV4
db: UniProt

SequenceSite118
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite117
type: SequenceSite
position status: EQUAL
sequence position: 207

UnificationXref365
type: UnificationXref
id: REACT_27629
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27629.1

UnificationXref364
type: UnificationXref
id: 936755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936755

UnificationXref367
type: UnificationXref
id: REACT_27282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27282.1

UnificationXref366
type: UnificationXref
id: 936642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936642

SequenceSite112
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref361
type: UnificationXref
id: P9WP55
db: UniProt

SequenceSite111
type: SequenceSite
position status: EQUAL
sequence position: 182

UnificationXref360
type: UnificationXref
id: REACT_3649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3649.2

Guanosine 5'-diphosphate
type: SmallMoleculeReference
name: GDP
name: Guanosine diphosphate
name: GDP [ChEBI:17552]
xref: UnificationXref287

SequenceSite110
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref363
type: UnificationXref
id: REACT_27506
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27506.1

UnificationXref362
type: UnificationXref
id: 936587
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936587

UnificationXref99
type: UnificationXref
id: REACT_27216
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27216.1

UnificationXref98
type: UnificationXref
id: 879299
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879299

UnificationXref370
type: UnificationXref
id: REACT_27651
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27651.1

UnificationXref95
type: UnificationXref
id: REACT_27869
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27869.1

UnificationXref94
type: UnificationXref
id: 879260
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879260

UnificationXref97
type: UnificationXref
id: REACT_27208
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27208.1

UnificationXref96
type: UnificationXref
id: 879327
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879327

UnificationXref91
type: UnificationXref
id: O53430
db: UniProt

UnificationXref90
type: UnificationXref
id: REACT_5076
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5076.2

UnificationXref93
type: UnificationXref
id: REACT_27769
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27769.1

UnificationXref92
type: UnificationXref
id: 879253
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879253

SequenceSite129
type: SequenceSite
position status: EQUAL
sequence position: 161

SequenceSite128
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref379
type: UnificationXref
id: REACT_27689
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27689.1

SequenceSite125
type: SequenceSite
position status: EQUAL
sequence position: 441

SequenceSite124
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite127
type: SequenceSite
position status: EQUAL
sequence position: 77

SequenceSite126
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite121
type: SequenceSite
position status: EQUAL
sequence position: 808

UnificationXref374
type: UnificationXref
id: REACT_27172
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27172.1

SequenceSite120
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref373
type: UnificationXref
id: 936745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936745

SequenceSite123
type: SequenceSite
position status: EQUAL
sequence position: 573

UnificationXref372
type: UnificationXref
id: REACT_27761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27761.1

SequenceSite122
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref371
type: UnificationXref
id: 936725
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936725

UnificationXref378
type: UnificationXref
id: 936619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936619

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref437

UnificationXref377
type: UnificationXref
id: P9WP33
db: UniProt

UnificationXref376
type: UnificationXref
id: REACT_27198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27198.1

UnificationXref375
type: UnificationXref
id: 936721
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936721

UnificationXref86
type: UnificationXref
id: 879248
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879248

UnificationXref85
type: UnificationXref
id: REACT_27640
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27640.1

UnificationXref84
type: UnificationXref
id: 879286
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879286

UnificationXref83
type: UnificationXref
id: P9WJM7
db: UniProt

UnificationXref380
type: UnificationXref
id: MOD:01625
db: MOD

UnificationXref89
type: UnificationXref
id: 29416
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29416

UnificationXref381
type: UnificationXref
id: 936718
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936718

UnificationXref88
type: UnificationXref
id: CHEBI:15366
db: ChEBI

UnificationXref87
type: UnificationXref
id: REACT_27291
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27291.1

UnificationXref82
type: UnificationXref
id: REACT_27569
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27569.2

UnificationXref81
type: UnificationXref
id: 879289
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879289

UnificationXref80
type: UnificationXref
id: CHEBI:16768
db: ChEBI

http://identifiers.org/pubmed/21238944
type: PublicationXref
id: 21238944
author: Rath, P
author: Shi, S
author: Ehrt, S
author: Venugopal, A
author: Schnappinger, D
author: Bryk, R
author: Rhee, K
author: Nathan, C
db: Pubmed
title: Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes
source: Cell Host Microbe 9:21-31
year: 2011

SequenceSite139
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite138
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite137
type: SequenceSite
position status: EQUAL
sequence position: 740

SequenceSite136
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite135
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite134
type: SequenceSite
position status: EQUAL
sequence position: 33

UnificationXref383
type: UnificationXref
id: P9WMN7
db: UniProt

SequenceSite133
type: SequenceSite
position status: EQUAL
sequence position: 949

UnificationXref382
type: UnificationXref
id: REACT_27530
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27530.1

SequenceSite132
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref385
type: UnificationXref
id: REACT_27772
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27772.1

SequenceSite131
type: SequenceSite
position status: EQUAL
sequence position: 442

UnificationXref384
type: UnificationXref
id: 936744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936744

SequenceSite130
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref387
type: UnificationXref
id: REACT_27199
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27199.1

UnificationXref386
type: UnificationXref
id: 936590
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936590

UnificationXref389
type: UnificationXref
id: 936706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936706

UnificationXref388
type: UnificationXref
id: CHEBI:15811
db: ChEBI

UnificationXref73
type: UnificationXref
id: REACT_27279
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27279.1

UnificationXref72
type: UnificationXref
id: 879319
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879319

UnificationXref75
type: UnificationXref
id: 76183
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76183

UnificationXref74
type: UnificationXref
id: CHEBI:15351
db: ChEBI

UnificationXref77
type: UnificationXref
id: CHEBI:15346
db: ChEBI

UnificationXref76
type: UnificationXref
id: REACT_2630
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2630.2

UnificationXref390
type: UnificationXref
id: REACT_27529
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27529.1

UnificationXref79
type: UnificationXref
id: REACT_2732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2732.2

UnificationXref391
type: UnificationXref
id: MOD:01777
db: MOD

UnificationXref78
type: UnificationXref
id: 76194
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194

UnificationXref392
type: UnificationXref
id: 936690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936690

O2.-
type: SmallMoleculeReference
name: superoxide
name: O2-
name: superoxide [ChEBI:18421]
xref: UnificationXref699

electron
type: SmallMoleculeReference
name: electron [ChEBI:10545]
xref: UnificationXref165

Mg++
type: SmallMoleculeReference
name: Magnesium [ChEBI:18420]
name: Mg2+
name: Magnesium
xref: UnificationXref202

UnificationXref71
type: UnificationXref
id: REACT_27345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27345.1

UnificationXref70
type: UnificationXref
id: 879241
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879241

UnificationXref311
type: UnificationXref
id: REACT_27930
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27930.2

UnificationXref312
type: UnificationXref
id: 70986
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70986

SequenceSite140
type: SequenceSite
position status: EQUAL
sequence position: 130

SequenceSite141
type: SequenceSite
position status: EQUAL
sequence position: 133

UnificationXref310
type: UnificationXref
id: 936689
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936689

SequenceSite142
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite143
type: SequenceSite
position status: EQUAL
sequence position: 177

Rv1876
type: ProteinReference
name: MTCY180.42c
name: UniProt:P9WPQ9 bfr
name: bfr
name: bfrA
xref: UnificationXref542
comment: FUNCTION: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex (By similarity).
organism: Mycobacterium tuberculosis H37Rv

SequenceSite144
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite145
type: SequenceSite
position status: EQUAL
sequence position: 553

SequenceSite146
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref319
type: UnificationXref
id: 936655
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936655

SequenceSite147
type: SequenceSite
position status: EQUAL
sequence position: 553

SequenceSite148
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref317
type: UnificationXref
id: 936704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936704

SequenceSite149
type: SequenceSite
position status: EQUAL
sequence position: 464

UnificationXref318
type: UnificationXref
id: REACT_27449
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27449.1

UnificationXref315
type: UnificationXref
id: 936694
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936694

UnificationXref316
type: UnificationXref
id: REACT_27921
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27921.1

UnificationXref313
type: UnificationXref
id: REACT_5528
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5528.1

UnificationXref314
type: UnificationXref
id: P9WIK3
db: UniProt

SequenceSite151
type: SequenceSite
position status: EQUAL
sequence position: 335

UnificationXref320
type: UnificationXref
id: REACT_27147
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27147.1

SequenceSite152
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref321
type: UnificationXref
id: CHEBI:33723
db: ChEBI

UnificationXref322
type: UnificationXref
id: 937266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937266

SequenceSite150
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref323
type: UnificationXref
id: REACT_27531
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27531.2

SequenceSite155
type: SequenceSite
position status: EQUAL
sequence position: 33

SequenceSite156
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite153
type: SequenceSite
position status: EQUAL
sequence position: 123

SequenceSite154
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite159
type: SequenceSite
position status: EQUAL
sequence position: 336

UnificationXref328
type: UnificationXref
id: REACT_27967
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27967.1

UnificationXref329
type: UnificationXref
id: CHEBI:15138
db: ChEBI

SequenceSite157
type: SequenceSite
position status: EQUAL
sequence position: 123

SequenceSite158
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref324
type: UnificationXref
id: P9WNE7
db: UniProt

UnificationXref325
type: UnificationXref
id: 937262
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937262

UnificationXref326
type: UnificationXref
id: REACT_27862
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27862.1

Nitrogen monoxide
type: SmallMoleculeReference
name: Nitric oxide [ChEBI:7583]
name: Nitric oxide
name: NO
xref: UnificationXref568

UnificationXref327
type: UnificationXref
id: 937263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937263

NADPH
type: SmallMoleculeReference
name: NADPH [ChEBI:16474]
name: TPNH
xref: UnificationXref170

Reactome
type: Provenance
comment: http://www.reactome.org

SequenceSite164
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite165
type: SequenceSite
position status: EQUAL
sequence position: 579

UnificationXref330
type: UnificationXref
id: 936697
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936697

SequenceSite166
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite167
type: SequenceSite
position status: EQUAL
sequence position: 283

SequenceSite160
type: SequenceSite
position status: EQUAL
sequence position: 20

UnificationXref333
type: UnificationXref
id: 937265
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937265

UDPglucose
type: SmallMoleculeReference
name: UDP-D-glucose
name: UDPglucose [ChEBI:18066]
name: UDP-glucose
xref: UnificationXref183

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

SequenceSite161
type: SequenceSite
position status: EQUAL
sequence position: 710

UnificationXref334
type: UnificationXref
id: REACT_27355
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27355.2

SequenceSite162
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref331
type: UnificationXref
id: REACT_27817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27817.2

SequenceSite163
type: SequenceSite
position status: EQUAL
sequence position: 859

UnificationXref332
type: UnificationXref
id: CHEBI:33722
db: ChEBI

UnificationXref337
type: UnificationXref
id: CHEBI:28599
db: ChEBI

UnificationXref338
type: UnificationXref
id: 936662
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936662

UnificationXref335
type: UnificationXref
id: 937267
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937267

UnificationXref336
type: UnificationXref
id: REACT_27419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27419.1

SequenceSite168
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite169
type: SequenceSite
position status: EQUAL
sequence position: 159

UnificationXref339
type: UnificationXref
id: REACT_27598
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27598.2

UnificationXref5
type: UnificationXref
id: CHEBI:18297
db: ChEBI

trxA
type: ProteinReference
name: Rv3914
name: UniProt:P9WG67 trxA
name: trxC
name: MTV028.05
name: trx
xref: UnificationXref303
comment: FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).
organism: Mycobacterium tuberculosis H37Rv

UnificationXref6
type: UnificationXref
id: 870330
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870330

http://identifiers.org/pubmed/19376862
type: PublicationXref
id: 19376862
author: Kaushal, D
author: Mehra, S
db: Pubmed
title: Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH
source: J Bacteriol 191:3965-80
year: 2009

UnificationXref7
type: UnificationXref
id: REACT_27390
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27390.2

UnificationXref8
type: UnificationXref
id: CHEBI:29105
db: ChEBI

UnificationXref9
type: UnificationXref
id: 29426
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426

UnificationXref1
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref2
type: UnificationXref
id: CHEBI:17665
db: ChEBI

http://identifiers.org/pubmed/22232695
type: PublicationXref
id: 22232695
author: Matsunaga, I
author: Wei, JR
author: Layre, E
author: Moody, DB
author: Murry, JP
author: Rubin, EJ
author: McConnell, MJ
author: Madigan, CA
author: Barry CE, 3rd
author: Cheng, TY
author: Debono, CA
author: Young, DC
author: Rodriguez, GM
db: Pubmed
title: Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis
source: Proc Natl Acad Sci U S A 109:1257-62
year: 2012

UnificationXref3
type: UnificationXref
id: 30537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30537

UnificationXref4
type: UnificationXref
id: REACT_3817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3817.2

UnificationXref340
type: UnificationXref
id: P9WJ03
db: UniProt

UniProt:P9WQ19 treS
type: ProteinReference
name: treS
name: Rv0126
xref: UnificationXref212
comment: FUNCTION: Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS probably plays a key role in the utilization of trehalose for the production of glycogen, and might also function as a sensor and/or regulator of trehalose levels within the cell. Thus, when trehalose levels in the cell become dangerously low, TreS could expedite the conversion of glycogen to maltose via its amylase activity and then convert the maltose to trehalose; but this enzyme also could expedite or promote the conversion of trehalose to glycogen when cytoplasmic trehalose levels become too high.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref341
type: UnificationXref
id: 936705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936705

UnificationXref342
type: UnificationXref
id: REACT_27933
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27933.1

UnificationXref343
type: UnificationXref
id: 936607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936607

SequenceSite171
type: SequenceSite
position status: EQUAL
sequence position: 181

UnificationXref344
type: UnificationXref
id: REACT_27369
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27369.1

UnificationXref345
type: UnificationXref
id: 936703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936703

UnificationXref346
type: UnificationXref
id: REACT_27285
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27285.1

UnificationXref347
type: UnificationXref
id: CHEBI:17115
db: ChEBI

UnificationXref348
type: UnificationXref
id: 200736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200736

UnificationXref349
type: UnificationXref
id: REACT_11439
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11439.2

SequenceSite170
type: SequenceSite
position status: EQUAL
sequence position: 2

MTCY48.02
type: ProteinReference
name: Rv1563c
name: treY
name: UniProt:P9WQ21 treY
xref: UnificationXref222
comment: FUNCTION: Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide, maltooligosyl trehalose (alpha- maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Rv1562c
type: ProteinReference
name: UniProt:P9WQ23 treZ
name: treZ
name: MTCY48.03
xref: UnificationXref229
comment: FUNCTION: Is involved in the biosynthesis of trehalose but not in that of capsular glucan and glycogen.
organism: Mycobacterium tuberculosis H37Rv

MTCY09F9.32c
type: ProteinReference
name: tpx
name: UniProt:P9WG35 tpx
name: Rv1932
xref: UnificationXref616
comment: FUNCTION: Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).
organism: Mycobacterium tuberculosis H37Rv

carboxymycobactin [ChEBI:62579]
type: SmallMoleculeReference
name: carboxymycobactin
xref: UnificationXref796

N(alpha)-(L-gamma-glutamyl) amino acid
type: SmallMoleculeReference
name: L-gamma-Glutamyl amino acid
name: L-gamma-glutamyl amino acid
name: 5-L-glutamyl amino acid
name: 5-L-glutamyl amino acid [ChEBI:15857]
xref: UnificationXref656

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref240

UnificationXref397
type: UnificationXref
id: 936676
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936676

UnificationXref398
type: UnificationXref
id: REACT_27798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27798.1

UnificationXref399
type: UnificationXref
id: 936569
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936569

UnificationXref393
type: UnificationXref
id: REACT_27519
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27519.1

UnificationXref394
type: UnificationXref
id: P9WP53
db: UniProt

UnificationXref395
type: UnificationXref
id: 936710
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936710

UnificationXref396
type: UnificationXref
id: REACT_27716
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27716.1

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref173

Rv2178c
type: ProteinReference
name: UniProt:O53512 aroG
name: aroG
xref: UnificationXref446
comment: CATALYTIC ACTIVITY Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.SIMILARITY Belongs to the class-II DAHP synthase family.
organism: Mycobacterium tuberculosis

MTCY159.19
type: ProteinReference
name: Rv2537c
name: aroD
name: aroQ
name: UniProt:P9WPX7 aroQ
xref: UnificationXref467
comment: FUNCTION: Catalyzes a trans-dehydration via an enolate intermediate (By similarity).
organism: Mycobacterium tuberculosis H37Rv

UniProt:P9WPX9 aroB
type: ProteinReference
name: MTCY159.18
name: Rv2538c
name: aroB
xref: UnificationXref459
comment: CATALYTIC ACTIVITY: 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
organism: Mycobacterium tuberculosis H37Rv

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref136

O-Acetyl-L-serine
type: SmallMoleculeReference
name: O-Acetyl-L-serine [ChEBI:7668]
name: O3-Acetyl-L-serine
xref: UnificationXref350

MTCY159.17
type: ProteinReference
name: aroK
name: Rv2539c
name: UniProt:P9WPY3 aroK
xref: UnificationXref487
comment: FUNCTION: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
organism: Mycobacterium tuberculosis H37Rv

UniProt:P9WPY1 aroC
type: ProteinReference
name: MTCY159.16
name: Rv2540c
name: aroF
name: aroC
xref: UnificationXref508
comment: CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
organism: Mycobacterium tuberculosis H37Rv

3'-Phospho-5'-adenylyl sulfate
type: SmallMoleculeReference
name: 3'-Phosphoadenosine 5'-phosphosulfate
name: 3'-Phosphoadenylyl sulfate [ChEBI:17980]
name: 3'-Phosphoadenylyl sulfate
name: PAPS
xref: UnificationXref284

Rv3227
type: ProteinReference
name: MTCY20B11.02
name: UniProt:P9WPY5 aroA
name: aroA
xref: UnificationXref497
comment: CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.
organism: Mycobacterium tuberculosis H37Rv

Rv2259
type: ProteinReference
name: UniProt:O53533
name: adhE2
name: MT2320
xref: UnificationXref148
organism: Mycobacterium tuberculosis

Electrophilic substrate-mycothiol conjugate
type: SmallMolecule
data source: Reactome
member physical entity: acetophenone-mycothiol conjugate
member physical entity: N-ethylsuccinimide-mycothiol conjugate
xref: UnificationXref119
xref: UnificationXref120
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 879246

IrtA
type: Protein
entity reference: Rv1348
data source: Reactome
xref: UnificationXref836
xref: UnificationXref835
feature: FragmentFeature75
cellular location: plasma membrane
comment: Reactome DB_ID: 1222596

N-ethylsuccinimide
type: SmallMolecule
entity reference: ChEBI:44348 N-ethylsuccinimide
data source: Reactome
xref: UnificationXref110
xref: UnificationXref109
cellular location: cytosol
comment: Reactome DB_ID: 879288
display name: NETSU

Lactoferrin
type: Protein
entity reference: GIG12
data source: Reactome
name: Lactotransferrin
name: TRFL_HUMAN
xref: UnificationXref817
xref: UnificationXref816
feature: FragmentFeature74
cellular location: extracellular region
comment: Reactome DB_ID: 977171
display name: LTF

acetophenone
type: SmallMolecule
entity reference: Acetylbenzene
data source: Reactome
xref: UnificationXref106
xref: UnificationXref107
cellular location: cytosol
comment: Reactome DB_ID: 879294
display name: APN

Fgd1
type: Protein
entity reference: fgd
data source: Reactome
xref: UnificationXref790
xref: UnificationXref791
feature: FragmentFeature73
cellular location: cytosol
comment: Reactome DB_ID: 1500811

Electrophilic substrate
type: SmallMolecule
data source: Reactome
member physical entity: N-ethylsuccinimide
member physical entity: acetophenone
xref: UnificationXref112
xref: UnificationXref111
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 879233

acetophenone-mercapturic acid
type: SmallMolecule
entity reference: ChEBI:59632 (2R)-2-acetamido-3-phenacylsulfanylpropanoic acid
data source: Reactome
xref: UnificationXref125
xref: UnificationXref124
cellular location: cytosol
comment: Reactome DB_ID: 879267
display name: APN-MTA

Electrophilic substance-mercapturic acid
type: SmallMolecule
data source: Reactome
member physical entity: acetophenone-mercapturic acid
member physical entity: N-ethylsuccinimide-mercapturic acid
xref: UnificationXref129
xref: UnificationXref130
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 879237

acetophenone-mycothiol conjugate
type: SmallMolecule
entity reference: acetophenone-mycothiol conjugate
data source: Reactome
xref: UnificationXref118
xref: UnificationXref117
cellular location: cytosol
comment: Reactome DB_ID: 879244
display name: APN-MYT

N-ethylsuccinimide-mycothiol conjugate
type: SmallMolecule
entity reference: ChEBI:59629 N-ethylsuccinimide-mycothiol conjugate
data source: Reactome
xref: UnificationXref115
xref: UnificationXref114
cellular location: cytosol
comment: Reactome DB_ID: 879283

mycothiol binds formaldehyde and is dehydrogenated
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.66
xref: http://identifiers.org/pubmed/12809551
xref: UnificationXref153
xref: UnificationXref154
left: DPN
left: formaldehyde
left: mycothiol
comment: In the detoxification of formaldehyde, mycothiol first binds to the molecule forming a hydroxymethyl adduct intermediate (M-S-CH2OH, not shown), which is dehydrogenated by the bifunctional MscR enzyme to formylmycothiol (Vogt et al, 2003).
comment: Edited: Jassal, B, 2011-02-16
comment: Authored: Stephan, R, 2010-06-15
comment: Reviewed: Warner, D, 2010-11-25
right: NADH
right: formylmycothiol
right: proton

1,4-alpha-glucan is converted to glucanotrehalose
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.99.15
xref: UnificationXref225
xref: UnificationXref226
xref: http://identifiers.org/pubmed/10658666
left: (1,4-alpha-glycosyl)n
comment: Linear alpha-1,4-glucans are modified at one end to a glucanotrehalose by the enzyme TreY (De Smet et al, 2000).
comment: Authored: Stephan, R, 2010-05-29
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: glucanotrehalose

Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.2.1.141
xref: UnificationXref233
xref: UnificationXref232
xref: http://identifiers.org/pubmed/10658666
left: Water
left: glucanotrehalose
comment: From the glucanotrehalose, the enzyme TreZ cleaves one molecule of trehalose, leaving a linear glucan that is two sugars shorter than before. This is the rate-limiting step in the TreYZ pathway of trehalose biosynthesis (De Smet et al, 2000).
comment: Authored: Stephan, R, 2010-05-29
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: alpha,alpha'-trehalose
right: (1,4-alpha-glycosyl)(n-2)

Trehalose-6-phosphate is hydrolyzed to trehalose
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.12
xref: http://identifiers.org/pubmed/15158675
xref: UnificationXref207
xref: UnificationXref208
xref: http://identifiers.org/pubmed/10658666
left: alpha,alpha'-trehalose-6-phosphate
left: Water
comment: Hydrolysis of trehalose phosphate, catalyzed by OtsB2, gives trehalose. The enzyme needs magnesium for its activity. A second homologue, OtsB1 is non-functional (De Smet et al, 2000; Edavana et al, 2004).
comment: Authored: Stephan, R, 2010-05-29
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: alpha,alpha'-trehalose

Maltose is converted to trehalose
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 5.4.99.16
xref: UnificationXref216
xref: UnificationXref215
xref: http://identifiers.org/pubmed/10658666
left: maltose
comment: Maltose is converted to trehalose. The enzymatic activity of TreS for this reaction is 2-5 fold stronger than for the reverse reaction (De Smet et al, 2000).
comment: Authored: Stephan, R, 2010-05-29
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: alpha,alpha'-trehalose

mycothione is reduced to mycothiol
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.1.15
xref: http://identifiers.org/pubmed/10512639
xref: UnificationXref179
xref: http://identifiers.org/pubmed/17286835
xref: UnificationXref180
participant stoichiometry: Stoichiometry12
left: mycothione
left: NADPH
left: proton
comment: Authored: Stephan, R, 2010-06-08
comment: Edited: Jassal, B, 2011-02-16
comment: Mycothiol is recycled using a reduction equivalent (NADPH/H+) and the help of the mycothione reductase enzyme. Although a mtr null mutant was obtained by McAdam and coworkers in M. tuberculosis, another study by Sassetti suggests the enzyme is essential in the H37Rv strain. It appears possible that thioredoxin reductases can provide some enzymatic rest activity. (Patel and Blanchard, 1999; Rawat and Av-Gay, 2007)
comment: Reviewed: Warner, D, 2010-11-25
right: NADP+
right: mycothiol

Glucose is transferred from UDP-glucose onto glucose-6-phosphate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.1.15
xref: http://identifiers.org/pubmed/10658666
xref: http://identifiers.org/pubmed/12473104
xref: UnificationXref194
xref: UnificationXref195
left: UDPglucose
left: alpha-D-Glucose 6-phosphate
comment: Authored: Stephan, R, 2010-05-29
comment: Trehalose phosphate synthase, which is a tetramer in solution, catalyzes the transfer of glucose from UDP onto glucose-6-phosphate. The enzyme is stimulated by manganese ions and can also accept ADP-, CDP-, GDP- and TDP-glucose as well as UDP-glucose (De Smet et al, 2000; Pan et al, 2008).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: alpha,alpha'-trehalose-6-phosphate
right: uridine 5'-diphosphate

formylmycothiol hydrolyzes into mycothiol and formate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref158
xref: http://identifiers.org/pubmed/12809551
xref: UnificationXref159
left: Water
left: formylmycothiol
comment: Formylmycothiol, like any S-formyl ester, is unstable and quickly hydrolyzes into mycothiol and formate (Vogt et al, 2003).
comment: Edited: Jassal, B, 2011-02-16
comment: Authored: Stephan, R, 2010-06-15
comment: Reviewed: Warner, D, 2010-11-25
right: mycothiol
right: proton
right: Formic acid

mycothiol is oxidized to mycothione
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref168
xref: UnificationXref169
xref: http://identifiers.org/pubmed/17286835
participant stoichiometry: Stoichiometry10
participant stoichiometry: Stoichiometry11
participant stoichiometry: Stoichiometry9
left: mycothiol
comment: The oxidation of mycothiol provides electrons for the maintenance of cell redox homeostasis. In which reactions exactly those electrons are used is unknown. A possibility is the existence of MSH-dependent peroxidases. (Rawat and Av-Gay, 2007)
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-12
right: mycothione
right: electron
right: proton

Lpd
type: Protein
entity reference: MTV038.06
data source: Reactome
xref: UnificationXref760
xref: UnificationXref761
feature: FragmentFeature69
cellular location: cytosol
comment: Reactome DB_ID: 1222708

Acetate
type: SmallMolecule
entity reference: Acetate [ChEBI:15366]
data source: Reactome
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref89
xref: UnificationXref90
cellular location: cytosol
comment: Reactome DB_ID: 29416
display name: CH3COO-

TrxB
type: Protein
entity reference: Rv3913
data source: Reactome
xref: UnificationXref770
xref: UnificationXref769
feature: FragmentFeature70
cellular location: cytosol
comment: Reactome DB_ID: 1222537

coenzyme A
type: SmallMolecule
entity reference: CoA-SH
data source: Reactome
xref: UnificationXref79
xref: UnificationXref78
cellular location: cytosol
comment: Reactome DB_ID: 76194
display name: CoA-SH

dlaT(ox.)
type: Protein
entity reference: MTCY190.26
data source: Reactome
xref: UnificationXref752
xref: UnificationXref753
feature: FragmentFeature68
cellular location: cytosol
comment: Reactome DB_ID: 1222687

mycothiol
type: SmallMolecule
entity reference: Mycothiol [ChEBI:7040]
data source: Reactome
xref: UnificationXref82
xref: UnificationXref81
cellular location: cytosol
comment: Reactome DB_ID: 879289
display name: MSH

TrxA/B1 (ox.)
type: Protein
data source: Reactome
member physical entity: TrxA(ox.)
member physical entity: TrxB1(ox.)
xref: UnificationXref782
xref: UnificationXref783
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1243098

TrxB1(ox.)
type: Protein
entity reference: trx-2
data source: Reactome
xref: UnificationXref780
xref: UnificationXref781
feature: ModificationFeature13
feature: FragmentFeature72
feature: ModificationFeature12
cellular location: cytosol
comment: Reactome DB_ID: 1222479

TrxA/B1
type: Protein
data source: Reactome
member physical entity: TrxA
member physical entity: TrxB1
xref: UnificationXref778
xref: UnificationXref779
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1243096

sulfate binds to SubI outside the membrane
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/11929522
xref: UnificationXref248
xref: UnificationXref249
left: SubI
left: inorganic sulfate
comment: The sulfate binding protein is localized in the plasma membrane using a lipid anchor. It is associated with the ATP sulfate influx pump and binds sulfate and probably also thiosulfate anions from the extracellular space (Wooff et al, 2002).
comment: Authored: Stephan, R, 2010-06-17
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: SubI--sulfate complex

TrxB1
type: Protein
entity reference: trx-2
data source: Reactome
xref: UnificationXref777
xref: UnificationXref776
feature: FragmentFeature71
cellular location: cytosol
comment: Reactome DB_ID: 1222614

AhpD
type: Protein
entity reference: ahpD
data source: Reactome
xref: UnificationXref742
xref: UnificationXref741
feature: FragmentFeature65
cellular location: cytosol
comment: Reactome DB_ID: 1222304

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref50
xref: UnificationXref51
cellular location: cytosol
comment: Reactome DB_ID: 113592
display name: ATP

KatG
type: Protein
entity reference: katG
data source: Reactome
xref: UnificationXref723
xref: UnificationXref722
feature: FragmentFeature64
cellular location: cytosol
comment: Reactome DB_ID: 1222678

dlaT
type: Protein
entity reference: MTCY190.26
data source: Reactome
xref: UnificationXref751
xref: UnificationXref750
feature: FragmentFeature67
cellular location: cytosol
comment: Reactome DB_ID: 1222478

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: L-2-Amino-3-mercaptopropionic acid
data source: Reactome
name: L-cysteine
xref: UnificationXref56
xref: UnificationXref57
cellular location: cytosol
comment: Reactome DB_ID: 111707
display name: L-Cys

AhpD(ox.)
type: Protein
entity reference: ahpD
data source: Reactome
xref: UnificationXref743
xref: UnificationXref744
feature: ModificationFeature11
feature: FragmentFeature66
feature: ModificationFeature10
cellular location: cytosol
comment: Reactome DB_ID: 1222360

glucosaminyl-inositol
type: SmallMolecule
entity reference: ChEBI:52283 glucosaminyl-inositol
data source: Reactome
xref: UnificationXref53
xref: UnificationXref54
cellular location: cytosol
comment: Reactome DB_ID: 879264
display name: GlcNI

diphosphate
type: SmallMolecule
entity reference: PPi
data source: Reactome
name: pyrophosphoric acid
name: pyrophosphate
xref: UnificationXref62
xref: UnificationXref63
cellular location: cytosol
comment: Reactome DB_ID: 111294
display name: PPi

desacetylmycothiol
type: SmallMolecule
entity reference: ChEBI:52285 desacetylmycothiol
data source: Reactome
xref: UnificationXref59
xref: UnificationXref60
cellular location: cytosol
comment: Reactome DB_ID: 879313
display name: DAMT

Acetyl coenzyme A
type: SmallMolecule
entity reference: Acetyl coenzyme A
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref75
xref: UnificationXref76
cellular location: cytosol
comment: Reactome DB_ID: 76183
display name: Ac-CoA

5'-Adenylic acid
type: SmallMolecule
entity reference: 5'-Adenylic acid
data source: Reactome
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
xref: UnificationXref65
xref: UnificationXref66
cellular location: cytosol
comment: Reactome DB_ID: 76577
display name: AMP

sulfate is activated to APS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.7.4
xref: UnificationXref280
xref: http://identifiers.org/pubmed/15615729
xref: http://identifiers.org/pubmed/15184554
xref: UnificationXref279
left: Adenosine 5'-triphosphate
left: inorganic sulfate
comment: Authored: Stephan, R, 2010-06-18
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Sufate is first activated by adding it to ATP, giving APS. Although both sulfate adenylyltransferase and APS kinase activities reside in the same enzyme complex, the intermediate APS is not channeled within the complex. Its accessibility ensures the functionality of the cysteine biosynthetic pathway (Pinto et al, 2004; Sun et al, 2005).
right: diphosphate
right: 5'-adenylyl sulfate

sulfate uptake in the cytosol
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.6.3.25
xref: UnificationXref266
xref: UnificationXref267
xref: http://identifiers.org/pubmed/11929522
left: Adenosine 5'-triphosphate
left: Water
left: SubI--sulfate complex
comment: The sulfate transporter of M. tuberculosis, a typical ABC transporter family ATPase, is the sole membrane transport protein in sulfate assimilation. It consists of the CysT/CysW/CysA proteins in 1:1:2 stoichiometry. cysA null mutants in M. bovis were unable to take up sulfate but could be rescued by M. tuberculosis cysA (Wooff et al, 2002).
comment: Authored: Stephan, R, 2010-06-17
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: SubI
right: Adenosine 5'-diphosphate
right: inorganic sulfate

acetylation of serine
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.1.30
xref: http://identifiers.org/pubmed/17567578
xref: http://identifiers.org/pubmed/19376862
xref: http://identifiers.org/pubmed/16436075
xref: UnificationXref357
xref: UnificationXref356
left: Acetyl coenzyme A
left: L-serine
comment: Although there is no direct evidence for CysE catalyzing the acetylation of serine, it has 58% identity with the serine acetyltransferase of Corynebacterium glutamicum and is upregulated in stress conditions (Haitani et al, 2006; Schnell et al, 2007; Mehra and Kaushal, 2009).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-06-24
right: O-acetylserine
right: coenzyme A

deacetylation of O-acetylserine and sulfhydrylation using CysK1
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.47
xref: http://identifiers.org/pubmed/17567578
xref: UnificationXref367
xref: UnificationXref366
left: O-acetylserine
left: sulfide
comment: Sulfhydrylation of O-acetylserine (OAS) is a four step process, as was shown with CysK1, consisting of 1) addition of OAS to pyridoxal phosphate, 2) deacetylation, 3) sulfhydrylation and 4) cleavage of cysteine. It remains to be shown that the enzyme binds to CysE, resulting in a bifunctional complex. Activity of CysK1 is not essential for M. tuberculosis (Schnell et al, 2007).
comment: Authored: Stephan, R, 2010-06-21
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: L-2-amino-3-mercaptopropionic acid
right: Acetate

deacetylation of O-acetylserine and sulfhydrylation using CysK2
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.47
xref: http://identifiers.org/pubmed/17567578
xref: http://identifiers.org/pubmed/19376862
xref: UnificationXref374
xref: UnificationXref373
left: O-acetylserine
left: sulfide
comment: Expression of the other enzyme catalyzing the sulfhydrylation of O-acetylserine, CysK2, is increased by oxidative stress (Mehra and Kaushal, 2009; Schnell et al, 2007).
comment: Authored: Stephan, R, 2010-06-21
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: L-2-amino-3-mercaptopropionic acid
right: Acetate

sulfur transfer to carrier protein
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.8
xref: http://identifiers.org/pubmed/16104727
xref: UnificationXref387
xref: UnificationXref386
left: sulfide
left: CysO
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: MoeZ appears to catalyze the transfer of sulfur (here sulfide) onto the sulfur carrier protein CysO where the C-terminus carboxyl group becomes a thiocarboxyl group. The small molecule substrate, as well as the exact enzymatic activity of MoeZ, is unknown (Burns et al, 2005).
comment: Authored: Stephan, R, 2010-08-10
right: CysO-COSH

APS is phosphorylated to PAPS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.25
xref: UnificationXref291
xref: UnificationXref290
xref: http://identifiers.org/pubmed/15615729
xref: http://identifiers.org/pubmed/15184554
participant stoichiometry: Stoichiometry23
left: Adenosine 5'-triphosphate
left: Water
left: 5'-adenylyl sulfate
left: Guanosine 5'-triphosphate
comment: Energy for the phosphorylation of APS comes from the hydrolysis of a GTP molecule. The resulting PAPS is used in M. tuberculosis by several sulfotransferases for the production of sulfolipids (Pinto et al, 2004; Sun et al, 2005).
comment: Authored: Stephan, R, 2010-06-18
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: PAPS
right: Guanosine 5'-diphosphate
right: Adenosine 5'-diphosphate
right: proton

PAPS is dephosphorylated to APS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.1.3.7
xref: UnificationXref300
xref: http://identifiers.org/pubmed/18454554
xref: UnificationXref299
left: Water
left: PAPS
comment: Authored: Stephan, R, 2010-08-19
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: PAPS dephosphorylation, as the reverse reaction to APS phosphorylation, may have a regulatory role in the sulfate metabolism of M. tuberculosis (Hatzios et al, 2008).
right: Phosphate
right: 5'-adenylyl sulfate

sulfite results from reduction of APS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.4.8
xref: http://identifiers.org/pubmed/12072441
xref: UnificationXref320
xref: http://identifiers.org/pubmed/16008502
xref: UnificationXref319
participant stoichiometry: Stoichiometry27
left: Trx(red.)
left: 5'-adenylyl sulfate
comment: Authored: Stephan, R, 2010-06-20
comment: Reduction and cleavage of the sulfate moiety of APS happens in two distinct steps. First, the C-terminal cysteine of CysH binds sulfite to form an enzyme-thiosulfonate intermediate, which is then reduced by a thioredoxin (donating two electrons, thereby freeing two protons) (Williams et al, 2002; Carroll et al, 2005).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: 5'-Adenylic acid
right: sulfite
right: TrxA(ox.)
right: proton

sulfite is reduced to sulfide
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.7.1
xref: http://identifiers.org/pubmed/15917234
xref: http://identifiers.org/pubmed/17644602
xref: UnificationXref345
xref: UnificationXref346
participant stoichiometry: Stoichiometry38
participant stoichiometry: Stoichiometry37
participant stoichiometry: Stoichiometry33
participant stoichiometry: Stoichiometry32
left: Ferrodoxin (reduced)
left: sulfite
left: proton
comment: Authored: Stephan, R, 2010-06-20
comment: Three molecules of reduced ferredoxin are needed to reduce sulfite to sulfide. Electrons are transferred to sulfite with the help of Sir, an enzyme with siroheme and an iron-sulfur cluster as cofactors (Schnell et al, 2005; Pinto et al, 2007).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Water
right: Ferrodoxin (oxidized)
right: sulfide

SecY
type: Protein
entity reference: MTV041.06
data source: Reactome
xref: UnificationXref682
xref: UnificationXref681
feature: FragmentFeature58
cellular location: plasma membrane
comment: Reactome DB_ID: 1222532

L-O-Phosphoserine
type: SmallMoleculeReference
name: O-Phospho-L-serine
name: 3-Phosphoserine
name: O-Phospho-L-serine [ChEBI:7692]
xref: UnificationXref388

SecG
type: Protein
entity reference: secG
data source: Reactome
xref: UnificationXref685
xref: UnificationXref684
feature: FragmentFeature59
cellular location: plasma membrane
comment: Reactome DB_ID: 1222634

SecE
type: Protein
entity reference: secE
data source: Reactome
xref: UnificationXref688
xref: UnificationXref687
feature: FragmentFeature60
cellular location: plasma membrane
comment: Reactome DB_ID: 1222436

SecF
type: Protein
entity reference: UniProt:P9WGN9 secF
data source: Reactome
xref: UnificationXref691
xref: UnificationXref690
feature: FragmentFeature61
cellular location: plasma membrane
comment: Reactome DB_ID: 1222653

SecA1
type: Protein
entity reference: UniProt:P9WGP5 secA1
data source: Reactome
xref: UnificationXref694
xref: UnificationXref693
feature: FragmentFeature62
cellular location: plasma membrane
comment: Reactome DB_ID: 1222746

SodC
type: Protein
entity reference: MTCY22G10.29
data source: Reactome
xref: UnificationXref714
xref: UnificationXref713
feature: FragmentFeature63
cellular location: plasma membrane
comment: Reactome DB_ID: 1222633

http://identifiers.org/pubmed/19948799
type: PublicationXref
id: 19948799
author: Smith, I
author: Rodriguez, GM
author: Wang, S
author: Ryndak, MB
db: Pubmed
title: The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain
source: J Bacteriol 192:861-9
year: 2010

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref49

UniProt:P9WKJ1 cysQ
type: ProteinReference
name: MTCY270.37
name: Rv2131c
name: cysQ
xref: UnificationXref292
comment: FUNCTION: Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo. Glucose-1-phosphate (G-1-P), p-nitrophenyl phosphate (pNPP), and beta-glycerol phosphate (beta-GP) are also good substrates, compared to I-1-P. With much lower efficiency, can also hydrolyze inositol 2-phosphate (I-2-P) and glucose-6-phosphate (G-6-P) in vitro, but not fructose-6-phosphate (F-6-P) and trehalose-6- phosphate (T-6-P).
organism: Mycobacterium tuberculosis H37Rv

http://identifiers.org/pubmed/16847086
type: PublicationXref
id: 16847086
author: Mizrahi, V
author: Warner, DF
db: Pubmed
title: Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
source: Clin Microbiol Rev 19:558-70
year: 2006

IrtB
type: Protein
entity reference: Rv1349
data source: Reactome
xref: UnificationXref838
xref: UnificationXref839
feature: FragmentFeature76
cellular location: plasma membrane
comment: Reactome DB_ID: 1222394

Rv2895c
type: Protein
entity reference: UniProt:P9WL31 Rv2895c
data source: Reactome
xref: UnificationXref842
xref: UnificationXref841
feature: FragmentFeature77
cellular location: plasma membrane
comment: Reactome DB_ID: 1222389

BfrA
type: Protein
entity reference: Rv1876
data source: Reactome
xref: UnificationXref851
xref: UnificationXref852
feature: FragmentFeature78
cellular location: cytosol
comment: Reactome DB_ID: 1562627

BfrB
type: Protein
entity reference: ftn
data source: Reactome
xref: UnificationXref860
xref: UnificationXref861
feature: FragmentFeature79
cellular location: cytosol
comment: Reactome DB_ID: 1562631

O-phospho-L-serine
type: SmallMolecule
entity reference: L-O-Phosphoserine
data source: Reactome
xref: UnificationXref390
xref: UnificationXref389
cellular location: cytosol
comment: Reactome DB_ID: 936706

cystathionine
type: SmallMolecule
entity reference: Cystathionine
data source: Reactome
xref: UnificationXref413
xref: UnificationXref414
cellular location: cytosol
comment: Reactome DB_ID: 936600
display name: CYSTA

O-acetylserine
type: SmallMolecule
entity reference: O-Acetyl-L-serine
data source: Reactome
xref: UnificationXref352
xref: UnificationXref351
cellular location: cytosol
comment: Reactome DB_ID: 936709
display name: OAcSer

Pyridoxal 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxal 5'-phosphate
data source: Reactome
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
xref: UnificationXref359
xref: UnificationXref360
cellular location: cytosol
comment: Reactome DB_ID: 29390
display name: PXLP

D-Erythrose 4-phosphate
type: SmallMolecule
entity reference: D-Erythrose 4-phosphate [ChEBI:16897]
data source: Reactome
xref: UnificationXref436
xref: UnificationXref435
cellular location: cytosol
comment: Reactome DB_ID: 29878
display name: E4P

MT2748
type: ProteinReference
name: Rv2674
name: UniProt:P71971
xref: UnificationXref643
organism: Mycobacterium tuberculosis

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid
data source: Reactome
name: Phosphoenolpyruvate
xref: UnificationXref438
xref: UnificationXref439
cellular location: cytosol
comment: Reactome DB_ID: 29492
display name: PEP

Ammonia
type: SmallMolecule
entity reference: Ammonia
data source: Reactome
xref: UnificationXref417
xref: UnificationXref416
cellular location: cytosol
comment: Reactome DB_ID: 29382
display name: NH3

http://identifiers.org/pubmed/18445278
type: PublicationXref
id: 18445278
author: Basso, LA
author: Frazzon, J
author: Nunes, JE
author: Santos, DS
author: Ely, F
author: Schroeder, EK
author: Palma, MS
db: Pubmed
title: The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase
source: BMC Biochem 9:13
year: 2008

2-oxobutanoic acid
type: SmallMolecule
entity reference: alpha-oxo-n-butyric acid
data source: Reactome
name: 2-Ketobutyrate
xref: UnificationXref419
xref: UnificationXref420
cellular location: cytosol
comment: Reactome DB_ID: 936714
display name: 2-oxobutanoate

DAHP(3-)
type: SmallMolecule
entity reference: (4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonatooxy)heptanoate(3-)
data source: Reactome
xref: UnificationXref441
xref: UnificationXref442
cellular location: cytosol
comment: Reactome DB_ID: 964909

MTCY21D4.09c
type: ProteinReference
name: UniProt:P9WKI1 ino1
name: ino1
name: Rv0046c
xref: UnificationXref12
comment: FUNCTION: Catalyzes the conversion of glucose 6-phosphate to 1D- myo-inositol 3-phosphate (By similarity).
organism: Mycobacterium tuberculosis H37Rv

Mn(III)
type: SmallMolecule
entity reference: Mn(III)
data source: Reactome
name: Mn(II)
name: Manganese
xref: UnificationXref445
xref: UnificationXref444
cellular location: cytosol
comment: Reactome DB_ID: 29418
display name: Mn2+

5'-adenylyl sulfate
type: SmallMolecule
entity reference: APS
data source: Reactome
name: Adenosine 5'-phosphosulfate
xref: UnificationXref269
xref: UnificationXref270
cellular location: cytosol
comment: Reactome DB_ID: 174370
display name: APS

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: Guanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref282
xref: UnificationXref283
cellular location: cytosol
comment: Reactome DB_ID: 29438
display name: GTP

PAPS
type: SmallMolecule
entity reference: 3'-Phospho-5'-adenylyl sulfate
data source: Reactome
xref: UnificationXref285
xref: UnificationXref286
cellular location: cytosol
comment: Reactome DB_ID: 158471

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: Guanosine 5'-diphosphate
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref289
xref: UnificationXref288
cellular location: cytosol
comment: Reactome DB_ID: 29420
display name: GDP

sulfite
type: SmallMolecule
entity reference: Sulfite [ChEBI:9344]
data source: Reactome
xref: UnificationXref311
xref: UnificationXref310
cellular location: cytosol
comment: Reactome DB_ID: 936689
display name: H2SO3

(4Fe-4S)(1+)
type: SmallMolecule
entity reference: ChEBI:33723 [4Fe-4S](1+)
data source: Reactome
xref: UnificationXref322
xref: UnificationXref323
cellular location: cytosol
comment: Reactome DB_ID: 937266

sulfide
type: SmallMolecule
entity reference: ChEBI:15138 sulfide
data source: Reactome
xref: UnificationXref330
xref: UnificationXref331
cellular location: cytosol
comment: Reactome DB_ID: 936697
display name: S(2-)

(4Fe-4S)(2+)
type: SmallMolecule
entity reference: [4Fe-4S](2+)
data source: Reactome
xref: UnificationXref333
xref: UnificationXref334
cellular location: cytosol
comment: Reactome DB_ID: 937265

siroheme
type: SmallMolecule
entity reference: Siroheme
data source: Reactome
xref: UnificationXref338
xref: UnificationXref339
cellular location: cytosol
comment: Reactome DB_ID: 936662
display name: SRHM

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Reactome
name: L-Ser
xref: UnificationXref348
xref: UnificationXref349
cellular location: cytosol
comment: Reactome DB_ID: 200736
display name: Ser

Methylene oxide
type: SmallMoleculeReference
name: Oxomethane
name: Methanal
name: Formaldehyde
name: Oxomethylene
name: Formaldehyde [ChEBI:16842]
xref: UnificationXref133

alpha,alpha'-trehalose-6-phosphate
type: SmallMolecule
entity reference: alpha,alpha'-Trehalose 6-phosphate
data source: Reactome
xref: UnificationXref187
xref: UnificationXref188
cellular location: cytosol
comment: Reactome DB_ID: 868701

alpha,alpha'-trehalose
type: SmallMolecule
entity reference: alpha,alpha-Trehalose
data source: Reactome
xref: UnificationXref198
xref: UnificationXref197
cellular location: cytosol
comment: Reactome DB_ID: 868614

MTCY22G10.29
type: ProteinReference
name: UniProt:P9WGE9 sodC
name: sodC
name: Rv0432
xref: UnificationXref712
comment: FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity).
organism: Mycobacterium tuberculosis H37Rv

sod
type: ProteinReference
name: Rv3846
name: MTCY01A6.22c
name: sodB
name: sodA
name: UniProt:P9WGE7 sodB
xref: UnificationXref669
comment: FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
organism: Mycobacterium tuberculosis H37Rv

Catalysis19
type: Catalysis
data source: Reactome
controlled: PAPS is dephosphorylated to APS
control type: ACTIVATION
xref: RelationshipXref39
xref: RelationshipXref40
controller: CysQ dimer

Catalysis18
type: Catalysis
data source: Reactome
controlled: APS is phosphorylated to PAPS
control type: ACTIVATION
xref: RelationshipXref37
xref: RelationshipXref38
controller: sulfate adenylyltransferase complex

Catalysis17
type: Catalysis
data source: Reactome
controlled: sulfate is activated to APS
control type: ACTIVATION
xref: RelationshipXref35
xref: RelationshipXref36
controller: sulfate adenylyltransferase complex

Catalysis16
type: Catalysis
data source: Reactome
controlled: sulfate uptake in the cytosol
control type: ACTIVATION
xref: RelationshipXref33
xref: RelationshipXref34
controller: sulfate ABC transporter

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref252
xref: UnificationXref251
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref236

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Reactome
name: Sulphate
name: Sulfate
xref: UnificationXref253
xref: UnificationXref254
cellular location: cytosol
comment: Reactome DB_ID: 174375
display name: SO4(2-)

Catalysis15
type: Catalysis
data source: Reactome
controlled: Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose
control type: ACTIVATION
xref: RelationshipXref31
xref: RelationshipXref30
controller: TreZ

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Reactome
name: Sulphate
xref: UnificationXref239
xref: UnificationXref238
cellular location: extracellular region
comment: Reactome DB_ID: 427648
display name: SO4(2-)

Catalysis14
type: Catalysis
data source: Reactome
controlled: 1,4-alpha-glucan is converted to glucanotrehalose
control type: ACTIVATION
xref: RelationshipXref28
xref: RelationshipXref29
controller: TreY

sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Reactome
xref: UnificationXref244
xref: UnificationXref245
cellular location: plasma membrane
comment: Reactome DB_ID: 936734
display name: SO4(2-)

Catalysis13
type: Catalysis
data source: Reactome
controlled: Maltose is converted to trehalose
control type: ACTIVATION
xref: RelationshipXref26
xref: RelationshipXref27
controller: TreS

(1,4-alpha-glycosyl)n
type: SmallMolecule
entity reference: 1,4-alpha-D-Glucan
data source: Reactome
xref: UnificationXref218
xref: UnificationXref219
cellular location: cytosol
comment: Reactome DB_ID: 868686

Catalysis12
type: Catalysis
data source: Reactome
controlled: Trehalose-6-phosphate is hydrolyzed to trehalose
control type: ACTIVATION
xref: RelationshipXref24
xref: RelationshipXref25
controller: OtsB-Mg2+

(1,4-alpha-glycosyl)(n-2)
type: SmallMolecule
entity reference: 1,4-alpha-D-Glucan
data source: Reactome
xref: UnificationXref227
xref: UnificationXref228
cellular location: cytosol
comment: Reactome DB_ID: 868632

Catalysis11
type: Catalysis
data source: Reactome
controlled: Glucose is transferred from UDP-glucose onto glucose-6-phosphate
control type: ACTIVATION
xref: RelationshipXref22
xref: RelationshipXref23
controller: OtsA tetramer

Mg++
type: SmallMolecule
entity reference: Mg++
data source: Reactome
name: Magnesium
xref: UnificationXref203
xref: UnificationXref204
cellular location: cytosol
comment: Reactome DB_ID: 29926
display name: Mg2+

Catalysis10
type: Catalysis
data source: Reactome
controlled: mycothione is reduced to mycothiol
control type: ACTIVATION
xref: RelationshipXref20
xref: RelationshipXref21
controller: Mtr

maltose
type: SmallMolecule
entity reference: Maltose [ChEBI:6668]
data source: Reactome
xref: UnificationXref210
xref: UnificationXref211
cellular location: cytosol
comment: Reactome DB_ID: 868706
display name: Mal

UDPglucose
type: SmallMolecule
entity reference: UDPglucose
data source: Reactome
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref184
xref: UnificationXref185
cellular location: cytosol
comment: Reactome DB_ID: 29410
display name: UDP-Glc

http://identifiers.org/pubmed/11970850
type: PublicationXref
id: 11970850
author: Deretic, V
author: Zahrt, TC
db: Pubmed
title: Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis
source: Antioxid Redox Signal 4:141-59
year: 2002

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref138
xref: UnificationXref137
cellular location: cytosol
comment: Reactome DB_ID: 29360
display name: NAD

mycothione
type: SmallMolecule
entity reference: mycothione
data source: Reactome
xref: UnificationXref164
xref: UnificationXref163
cellular location: cytosol
comment: Reactome DB_ID: 879252
display name: MSSM

electron
type: SmallMolecule
entity reference: electron
data source: Reactome
xref: UnificationXref166
xref: UnificationXref167
cellular location: cytosol
comment: Reactome DB_ID: 879326
display name: e-

NADPH
type: SmallMolecule
entity reference: NADPH
data source: Reactome
xref: UnificationXref172
xref: UnificationXref171
cellular location: cytosol
comment: Reactome DB_ID: 29364
display name: TPNH

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Reactome
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref174
xref: UnificationXref175
cellular location: cytosol
comment: Reactome DB_ID: 29366
display name: TPN

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref141
xref: UnificationXref140
cellular location: cytosol
comment: Reactome DB_ID: 73473

formylmycothiol
type: SmallMolecule
entity reference: ChEBI:15735 formylmycothiol
data source: Reactome
xref: UnificationXref143
xref: UnificationXref144
cellular location: cytosol
comment: Reactome DB_ID: 879271
display name: FMYC

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref147
xref: UnificationXref146
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

Formic acid
type: SmallMolecule
entity reference: Formic acid
data source: Reactome
name: Formate
name: Methanoic acid
xref: UnificationXref156
xref: UnificationXref157
cellular location: cytosol
comment: Reactome DB_ID: 29460
display name: HCOOH

formaldehyde
type: SmallMolecule
entity reference: Methylene oxide
data source: Reactome
xref: UnificationXref135
xref: UnificationXref134
cellular location: cytosol
comment: Reactome DB_ID: 879250
display name: CH2O

N-ethylsuccinimide-mercapturic acid
type: SmallMolecule
entity reference: ChEBI:59634 3-(1-ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanoic acid
data source: Reactome
xref: UnificationXref127
xref: UnificationXref128
cellular location: cytosol
comment: Reactome DB_ID: 879279

http://identifiers.org/pubmed/14594852
type: PublicationXref
id: 14594852
author: Sareen, D
author: Newton, GL
author: Buchmeier, NA
author: Fahey, RC
db: Pubmed
title: Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman
source: J Bacteriol 185:6736-40
year: 2003

http://identifiers.org/pubmed/20466922
type: PublicationXref
id: 20466922
author: Russell, DG
author: Barry CE, 3rd
author: Flynn, JL
db: Pubmed
title: Tuberculosis: what we don't know can, and does, hurt us
source: Science 328:852-6
year: 2010

UnificationXref13
type: UnificationXref
id: 879304
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879304

UnificationXref12
type: UnificationXref
id: P9WKI1
db: UniProt

UnificationXref11
type: UnificationXref
id: 83332
db: NCBI Taxonomy

UnificationXref10
type: UnificationXref
id: REACT_3201
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3201.3

UnificationXref409
type: UnificationXref
id: REACT_27316
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27316.1

ChEBI:52283 glucosaminyl-inositol
type: SmallMoleculeReference
name: glucosaminyl-inositol
name: GlcN-Ins
xref: UnificationXref52

Catalysis30
type: Catalysis
data source: Reactome
controlled: DHQ from DAHP dephosphorylation
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref64
controller: AroB

ChEBI:52285 desacetylmycothiol
type: SmallMoleculeReference
name: Cys-GlcN-Ins
name: desacetylmycothiol
xref: UnificationXref58

UnificationXref404
type: UnificationXref
id: 936660
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936660

Catalysis31
type: Catalysis
data source: Reactome
controlled: Dehydratation of DHQ yields DHS
control type: ACTIVATION
xref: RelationshipXref67
xref: RelationshipXref66
controller: AroQ dodecamer

UnificationXref403
type: UnificationXref
id: P9WHS1
db: UniProt

Catalysis32
type: Catalysis
data source: Reactome
controlled: Shikimate results from hydration of DHS
control type: ACTIVATION
xref: RelationshipXref69
xref: RelationshipXref68
controller: AroE dimer

UnificationXref402
type: UnificationXref
id: REACT_27223
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27223.1

Catalysis33
type: Catalysis
data source: Reactome
controlled: Phosphorylation of shikimate
control type: ACTIVATION
xref: RelationshipXref71
xref: RelationshipXref70
controller: AroK holoenzyme

UnificationXref401
type: UnificationXref
id: 936665
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936665

Catalysis34
type: Catalysis
data source: Reactome
controlled: EPSP from shikimate 3-phosphate
control type: ACTIVATION
xref: RelationshipXref72
xref: RelationshipXref73
controller: AroA

UnificationXref408
type: UnificationXref
id: 936747
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936747

Catalysis35
type: Catalysis
data source: Reactome
controlled: Dephosphorylation of EPSP yields chorismate
control type: ACTIVATION
xref: RelationshipXref75
xref: RelationshipXref74
controller: AroC-FMN

UnificationXref407
type: UnificationXref
id: REACT_27375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27375.1

Catalysis36
type: Catalysis
data source: Reactome
controlled: Ferritin takes up and mineralizes iron
control type: ACTIVATION
xref: RelationshipXref78
xref: RelationshipXref77
controller: BfrA

D-Erythrose 4-phosphate [ChEBI:16897]
type: SmallMoleculeReference
name: D-Erythrose 4-phosphate
xref: UnificationXref434

UnificationXref406
type: UnificationXref
id: 936637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936637

Catalysis37
type: Catalysis
data source: Reactome
controlled: Nitric oxide is oxidized to nitrate
control type: ACTIVATION
xref: RelationshipXref80
xref: RelationshipXref79
controller: GlbN:Heme dimer

UnificationXref405
type: UnificationXref
id: REACT_27427
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27427.1

Catalysis38
type: Catalysis
data source: Reactome
controlled: Peroxynitrite is reduced to nitrite by AhpC
control type: ACTIVATION
xref: RelationshipXref82
xref: RelationshipXref81
controller: AhpC hexamer

UnificationXref16
type: UnificationXref
id: REACT_27763
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27763.1

Catalysis39
type: Catalysis
data source: Reactome
controlled: Peroxynitrite is reduced by AhpE
control type: ACTIVATION
xref: RelationshipXref83
xref: RelationshipXref81
controller: AhpE dimer (red.)

UnificationXref17
type: UnificationXref
id: MI:0355
db: MI

UnificationXref14
type: UnificationXref
id: REACT_27370
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27370.1

UnificationXref15
type: UnificationXref
id: 879258
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879258

UnificationXref400
type: UnificationXref
id: REACT_27882
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27882.1

UnificationXref18
type: UnificationXref
id: 879331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879331

UnificationXref19
type: UnificationXref
id: REACT_27308
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27308.1

UnificationXref20
type: UnificationXref
id: CHEBI:16264
db: ChEBI

UnificationXref22
type: UnificationXref
id: REACT_3203
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3203.3

UnificationXref21
type: UnificationXref
id: 162756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162756

UnificationXref24
type: UnificationXref
id: 879263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879263

http://identifiers.org/pubmed/12207698
type: PublicationXref
id: 12207698
author: Dikshit, KL
author: Gardner, AM
author: Pathania, R
author: Gardner, PR
author: Navani, NK
db: Pubmed
title: Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli
source: Mol Microbiol 45:1303-14
year: 2002

UnificationXref23
type: UnificationXref
id: CHEBI:52443
db: ChEBI

http://identifiers.org/pubmed/12356471
type: PublicationXref
id: 12356471
author: Magalhães, ML
author: Basso, LA
author: Santos, DS
author: Pereira, CP
db: Pubmed
title: Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv
source: Protein Expr Purif 26:59-64
year: 2002

http://identifiers.org/pubmed/16288916
type: PublicationXref
id: 16288916
author: Baker, EN
author: Parker, EJ
author: Webby, CJ
author: Lott, JS
author: Baker, HM
db: Pubmed
title: The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes
source: J Mol Biol 354:927-39
year: 2005

http://identifiers.org/pubmed/18434308
type: PublicationXref
id: 18434308
author: Moreland, NJ
author: Baker, EN
author: Bashiri, G
author: Squire, CJ
db: Pubmed
title: Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
source: J Biol Chem 283:17531-41
year: 2008

Catalysis22
type: Catalysis
data source: Reactome
controlled: acetylation of serine
control type: ACTIVATION
xref: RelationshipXref46
xref: RelationshipXref47
controller: CysE

Same Catalyst Activity
type: RelationshipTypeVocabulary

Catalysis23
type: Catalysis
data source: Reactome
controlled: deacetylation of O-acetylserine and sulfhydrylation using CysK1
control type: ACTIVATION
xref: RelationshipXref48
xref: RelationshipXref49
controller: CysK1 dimer

Catalysis20
type: Catalysis
data source: Reactome
controlled: sulfite results from reduction of APS
control type: ACTIVATION
xref: RelationshipXref42
xref: RelationshipXref43
controller: CysH holoenzyme

Catalysis21
type: Catalysis
data source: Reactome
controlled: sulfite is reduced to sulfide
control type: ACTIVATION
xref: RelationshipXref44
xref: RelationshipXref45
controller: Sir holoenzyme

Catalysis26
type: Catalysis
data source: Reactome
controlled: OPS is added to the carrier sulfide
control type: ACTIVATION
xref: RelationshipXref54
xref: RelationshipXref55
controller: CysM dimer

Catalysis27
type: Catalysis
data source: Reactome
controlled: cleavage of L-cysteine from carrier protein
control type: ACTIVATION
xref: RelationshipXref57
xref: RelationshipXref56
controller: Mec-Zn++

Catalysis24
type: Catalysis
data source: Reactome
controlled: deacetylation of O-acetylserine and sulfhydrylation using CysK2
control type: ACTIVATION
xref: RelationshipXref48
xref: RelationshipXref50
controller: CysK2 holoenzyme

Catalysis25
type: Catalysis
data source: Reactome
controlled: sulfur transfer to carrier protein
control type: ACTIVATION
xref: RelationshipXref52
xref: RelationshipXref53
controller: MoeZ

UnificationXref25
type: UnificationXref
id: REACT_27622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27622.1

UnificationXref26
type: UnificationXref
id: CHEBI:15377
db: ChEBI

UnificationXref27
type: UnificationXref
id: 29356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

Catalysis28
type: Catalysis
data source: Reactome
controlled: Cysteine from cystathionine and vice versa
control type: ACTIVATION
xref: RelationshipXref58
xref: RelationshipXref59
controller: MetB dimer

UnificationXref28
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

Catalysis29
type: Catalysis
data source: Reactome
controlled: DHAP from Ery4P and PEP
control type: ACTIVATION
xref: RelationshipXref63
xref: RelationshipXref62
controller: AroG-Mn++ pentamer

UnificationXref29
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Catalysis50
type: Catalysis
data source: Reactome
controlled: AhpD reactivates AhpC
control type: ACTIVATION
xref: RelationshipXref105
xref: RelationshipXref104
controller: AhpD trimer

Catalysis52
type: Catalysis
data source: Reactome
controlled: Lpd reactivates dlaT
control type: ACTIVATION
xref: RelationshipXref108
xref: RelationshipXref107
controller: Lpd dimer

Catalysis51
type: Catalysis
data source: Reactome
controlled: DlaT reactivates AhpD
control type: ACTIVATION
xref: RelationshipXref106
xref: RelationshipXref104
controller: dlaT

OtsB
type: Protein
entity reference: Rv3372
data source: Reactome
xref: UnificationXref200
xref: UnificationXref201
feature: FragmentFeature10
cellular location: cytosol
comment: Reactome DB_ID: 868661

Catalysis57
type: Catalysis
data source: Reactome
controlled: Loaded mycobactin gets imported
control type: ACTIVATION
xref: RelationshipXref118
xref: RelationshipXref117
controller: IrtAB:Rv2895c

CysT
type: Protein
entity reference: UniProt:P71745
data source: Reactome
xref: UnificationXref259
xref: UnificationXref260
feature: FragmentFeature15
cellular location: plasma membrane
comment: Reactome DB_ID: 936743

Catalysis58
type: Catalysis
data source: Reactome
controlled: Iron is reduced and separates from mycobactin
control type: ACTIVATION
xref: RelationshipXref120
xref: RelationshipXref119
controller: IrtAB:Rv2895c

CysW
type: Protein
entity reference: UniProt:P71746
data source: Reactome
xref: UnificationXref257
xref: UnificationXref256
feature: FragmentFeature14
cellular location: plasma membrane
comment: Reactome DB_ID: 936681

UnificationXref429
type: UnificationXref
id: REACT_27170
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27170.1

Catalysis59
type: Catalysis
data source: Reactome
controlled: BfrA stores iron
control type: ACTIVATION
xref: RelationshipXref77
xref: RelationshipXref121
controller: BfrA complex

CysD
type: Protein
entity reference: UniProt:P9WIK1 cysD
data source: Reactome
xref: UnificationXref272
xref: UnificationXref273
feature: FragmentFeature17
cellular location: cytosol
comment: Reactome DB_ID: 936698

UnificationXref428
type: UnificationXref
id: 937192
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937192

CysA
type: Protein
entity reference: MTCY253.24
data source: Reactome
xref: UnificationXref262
xref: UnificationXref263
feature: FragmentFeature16
cellular location: plasma membrane
comment: Reactome DB_ID: 936656

UnificationXref427
type: UnificationXref
id: REACT_27903
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27903.1

Catalysis53
type: Catalysis
data source: Reactome
controlled: TrxA reactivates AhpC
control type: ACTIVATION
xref: RelationshipXref109
xref: RelationshipXref104
controller: TrxA

TreY
type: Protein
entity reference: MTCY48.02
data source: Reactome
xref: UnificationXref223
xref: UnificationXref224
feature: FragmentFeature11
cellular location: cytosol
comment: Reactome DB_ID: 868619

UnificationXref426
type: UnificationXref
id: 937193
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937193

Catalysis54
type: Catalysis
data source: Reactome
controlled: TrxB reactivates TrxA
control type: ACTIVATION
xref: RelationshipXref111
xref: RelationshipXref110
controller: TrxB dimer

TreS
type: Protein
entity reference: UniProt:P9WQ19 treS
data source: Reactome
xref: UnificationXref214
xref: UnificationXref213
cellular location: cytosol
comment: Reactome DB_ID: 868682

UnificationXref425
type: UnificationXref
id: REACT_27565
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27565.1

Catalysis55
type: Catalysis
data source: Reactome
controlled: TrxA/B1 reactivates Tpx
control type: ACTIVATION
xref: RelationshipXref112
xref: RelationshipXref104
controller: TrxA/B1

Lipid-OH
type: PhysicalEntity
data source: Reactome
xref: UnificationXref734
xref: UnificationXref735
cellular location: cytosol
comment: Reactome DB_ID: 1222348

SubI
type: Protein
entity reference: UniProt:P71744
data source: Reactome
xref: UnificationXref243
xref: UnificationXref242
feature: FragmentFeature13
cellular location: plasma membrane
comment: Reactome DB_ID: 936726

UnificationXref424
type: UnificationXref
id: 937237
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937237

Catalysis56
type: Catalysis
data source: Reactome
controlled: Fgd1 reactivates F420
control type: ACTIVATION
xref: RelationshipXref114
xref: RelationshipXref113
controller: Fgd1

TreZ
type: Protein
entity reference: Rv1562c
data source: Reactome
xref: UnificationXref231
xref: UnificationXref230
feature: FragmentFeature12
cellular location: cytosol
comment: Reactome DB_ID: 868672

UnificationXref423
type: UnificationXref
id: REACT_27605
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27605.1

Loaded mycobactin gets imported
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/19948799
xref: UnificationXref846
xref: UnificationXref845
left: Mycobactin:Fe3+
comment: The ABC-type transporter IrtA, probably complexed with IrtB and ViuB (Rv2895c), specifically transports iron-loaded mycobactin into the cytosol (Ryndak et al. 2009).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Mycobactin:Fe3+

UnificationXref422
type: UnificationXref
id: 937149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937149

UnificationXref421
type: UnificationXref
id: P9WGB7
db: UniProt

BfrA stores iron
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.16.3.1
xref: http://identifiers.org/pubmed/22101841
xref: UnificationXref858
xref: UnificationXref857
participant stoichiometry: Stoichiometry131
participant stoichiometry: Stoichiometry133
participant stoichiometry: Stoichiometry132
participant stoichiometry: Stoichiometry134
left: Fe(III)
left: Oxygen
left: proton
comment: Edited: Jassal, Bijay, 2011--0-9-
comment: Mtb bacterioferritin BfrA oxidises Fe2+ to Fe3+, migrates them to its centre, and collects thousands of them as FeO(OH) in the central mineral core from which they can be later remobilised (Reddy et al. 2012).
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: iron (ferric)

UnificationXref420
type: UnificationXref
id: REACT_27614
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27614.3

Iron is reduced and separates from mycobactin
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/18461140
xref: UnificationXref848
xref: UnificationXref847
participant stoichiometry: Stoichiometry130
participant stoichiometry: Stoichiometry126
participant stoichiometry: Stoichiometry125
participant stoichiometry: Stoichiometry129
participant stoichiometry: Stoichiometry128
participant stoichiometry: Stoichiometry127
left: Mycobactin:Fe3+
left: NADPH
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
comment: Authored: Stephan, R, 2011-01-10
right: Fe(III)
right: NADP+
right: proton
right: Mycobactin

BfrB stores iron
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.16.3.1
xref: http://identifiers.org/pubmed/8695634
xref: http://identifiers.org/pubmed/21494619
xref: UnificationXref866
xref: UnificationXref867
participant stoichiometry: Stoichiometry141
participant stoichiometry: Stoichiometry139
participant stoichiometry: Stoichiometry138
participant stoichiometry: Stoichiometry140
left: Fe(III)
left: Oxygen
left: proton
comment: Edited: Jassal, Bijay, 2011--0-9-
comment: Mtb bacterioferritin BfrB oxidises Fe2+ to Fe3+, migrates them to its centre, and collects thousands of them as FeO(OH) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996, Khare et al. 2011).
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: iron (ferric)

CysNC
type: Protein
entity reference: UniProt:P9WNM5 cysNC
data source: Reactome
xref: UnificationXref276
xref: UnificationXref275
feature: FragmentFeature18
cellular location: cytosol
comment: Reactome DB_ID: 936597

Mtb iron assimilation by chelation
type: Pathway
data source: Reactome
pathway component: Loaded mycobactin gets imported
pathway component: BfrA stores iron
pathway component: Iron is reduced and separates from mycobactin
pathway component: Carboxymycobactin and mycobactin exchange their iron load
pathway component: BfrB stores iron
pathway component: Carboxymycobactin binds iron from lactoferrin
pathway component: Mycobactin is exported
pathway component: Carboxymycobactin gets secreted
xref: RelationshipXref123
xref: http://identifiers.org/pubmed/17804665
xref: UnificationXref868
xref: UnificationXref869
pathway order: PathwayStep80
pathway order: PathwayStep83
pathway order: PathwayStep84
pathway order: PathwayStep81
pathway order: PathwayStep82
pathway order: PathwayStep77
pathway order: PathwayStep79
pathway order: PathwayStep78
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Uptake of iron in Mtb, especially when the bacterium is in the host, strongly depends on siderophores. Humans, through secretion of lactoferrin, maintain an iron concentration of 10^(-18) M within macrophages, and the bacterium has evolved the siderophores mycobactin T and exomycobactin T (formerly exochelin) to cope with this shortage. While nonpolar mycobactin T stays in the cell wall and only moves around in liquid droplets, polar exochelin is abundantly secreted. As it can bind iron with higher affinity than lactoferrin, it frequently scavenges iron ions from this molecule (Miethke & Marahiel 2007).
comment: Authored: Stephan, R, 2011-01-10
organism: Mycobacterium tuberculosis

Catalysis41
type: Catalysis
data source: Reactome
controlled: MscR reduces nitrosomycothiol to ammonia
control type: ACTIVATION
xref: RelationshipXref85
xref: RelationshipXref86
controller: MscR:Zn2+

Catalysis40
type: Catalysis
data source: Reactome
controlled: Peroxynitrite is reduced to nitrite by Tpx
control type: ACTIVATION
xref: RelationshipXref84
xref: RelationshipXref81
controller: Tpx dimer

Catalysis48
type: Catalysis
data source: Reactome
controlled: KatG reduces H2O2
control type: ACTIVATION
xref: RelationshipXref99
xref: RelationshipXref100
controller: KatG dimer

UnificationXref417
type: UnificationXref
id: REACT_3820
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3820.1

Catalysis49
type: Catalysis
data source: Reactome
controlled: AhpC reduces peroxidated lipids
control type: ACTIVATION
xref: RelationshipXref101
xref: RelationshipXref102
controller: AhpC hexamer

UnificationXref416
type: UnificationXref
id: 29382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29382

Catalysis46
type: Catalysis
data source: Reactome
controlled: SodC reduces superoxide to H2O2
control type: ACTIVATION
xref: RelationshipXref94
xref: RelationshipXref96
controller: SodC dimer

UnificationXref419
type: UnificationXref
id: 936714
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936714

Catalysis47
type: Catalysis
data source: Reactome
controlled: AhpC reduces H2O2
control type: ACTIVATION
xref: RelationshipXref98
xref: RelationshipXref97
controller: AhpC hexamer

UnificationXref418
type: UnificationXref
id: CHEBI:30831
db: ChEBI

Catalysis44
type: Catalysis
data source: Reactome
controlled: SodB gets secreted
control type: ACTIVATION
xref: RelationshipXref93
xref: RelationshipXref92
controller: Sec complex

UnificationXref413
type: UnificationXref
id: 936600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936600

Catalysis45
type: Catalysis
data source: Reactome
controlled: SodB reduces superoxide to H2O2
control type: ACTIVATION
xref: RelationshipXref94
xref: RelationshipXref95
controller: SodB tetramer

UnificationXref412
type: UnificationXref
id: CHEBI:17755
db: ChEBI

Catalysis42
type: Catalysis
data source: Reactome
controlled: MsrA/B reduces peptide-methionine S/R-sulfoxides
control type: ACTIVATION
xref: RelationshipXref88
xref: RelationshipXref87
controller: MsrA/B

UnificationXref415
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Catalysis43
type: Catalysis
data source: Reactome
controlled: Nitrosoglutathione gets cleaved to Cys(NO)-Gly
control type: ACTIVATION
xref: RelationshipXref89
xref: RelationshipXref90
controller: GgtA

UnificationXref414
type: UnificationXref
id: REACT_27420
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27420.2

UnificationXref411
type: UnificationXref
id: REACT_27306
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27306.1

Rv1079
type: ProteinReference
name: metB
name: UniProt:P9WGB7 metB
name: MTV017.32
xref: UnificationXref421
comment: FUNCTION: Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction (By similarity). In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
organism: Mycobacterium tuberculosis H37Rv

UnificationXref410
type: UnificationXref
id: 936654
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936654

UniProt:P9WL31 Rv2895c
type: ProteinReference
name: Rv2895c
name: MTCY274.26c
xref: UnificationXref840
organism: Mycobacterium tuberculosis H37Rv

CysO-COSH
type: Protein
entity reference: cfp10A
data source: Reactome
xref: UnificationXref381
xref: UnificationXref382
feature: FragmentFeature29
feature: ModificationFeature3
cellular location: cytosol
comment: Reactome DB_ID: 936718

CysO-CO-Cys
type: Protein
entity reference: cfp10A
data source: Reactome
xref: UnificationXref393
xref: UnificationXref392
feature: FragmentFeature31
feature: ModificationFeature4
cellular location: cytosol
comment: Reactome DB_ID: 936690

MoeZ
type: Protein
entity reference: UniProt:P9WMN7 moeZ
data source: Reactome
xref: UnificationXref385
xref: UnificationXref384
feature: FragmentFeature30
cellular location: cytosol
comment: Reactome DB_ID: 936744

UnificationXref52
type: UnificationXref
id: CHEBI:52283
db: ChEBI

AhpD reactivates AhpC
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref747
xref: UnificationXref748
xref: http://identifiers.org/pubmed/21238944
left: AhpD
left: AhpC(ox.)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from Lpd, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
comment: Authored: Stephan, R, 2011-01-10
right: AhpD(ox.)
right: AhpC

UnificationXref53
type: UnificationXref
id: 879264
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879264

http://identifiers.org/pubmed/2123856
type: PublicationXref
id: 2123856
author: Young, D
author: Garbe, T
author: Dougan, G
author: Jones, C
author: Charles, I
db: Pubmed
title: Cloning and characterization of the aroA gene from Mycobacterium tuberculosis
source: J Bacteriol 172:6774-82
year: 1990

UnificationXref50
type: UnificationXref
id: 113592
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref51
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

KatG reduces H2O2
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.6
xref: UnificationXref727
xref: UnificationXref726
xref: http://identifiers.org/pubmed/9395452
participant stoichiometry: Stoichiometry108
participant stoichiometry: Stoichiometry107
left: Hydrogen peroxide
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Another important antioxidant activity is the KatG catalase/peroxidase which also activates the anti-tuberculosis drug isoniazid (Nagy et al. 1997).
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: Oxygen

UnificationXref56
type: UnificationXref
id: 111707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111707

AhpC reduces H2O2
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.7
xref: UnificationXref720
xref: http://identifiers.org/pubmed/11799204
xref: UnificationXref719
participant stoichiometry: Stoichiometry106
left: Hydrogen peroxide
left: AhpC
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The versatile AhpC reduces hydrogen peroxide to water (Bryk et al. 2002).
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: AhpC(ox.)

UnificationXref57
type: UnificationXref
id: REACT_7424
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7424.4

AhpC reduces peroxidated lipids
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref737
xref: UnificationXref736
xref: http://identifiers.org/pubmed/11171096
left: Lipid-OOH
left: AhpC
comment: Reduction of peroxidated lipids depends on reduced AhpC, the only alkyl hydoperoxidase in Mtb (Chauhan & Mande 2001).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: Lipid-OH
right: AhpC(ox.)

UnificationXref54
type: UnificationXref
id: REACT_27804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27804.2

H2O2 gets scavenged by unsaturated lipid
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref733
xref: UnificationXref732
xref: http://identifiers.org/pubmed/11171096
left: Unsaturated lipid
left: Hydrogen peroxide
comment: Due to their abundance in Mycobacteria, lipids fulfill a buffering role in the tolerance of antioxidants. Lipid production is triggered by oxidative stress. The peroxidated lipid can be reduced by AhpC (Chauhan & Mande 2001).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Lipid-OOH

UnificationXref55
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Nitrosoglutathione gets cleaved to Cys(NO)-Gly
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.3.2.2
xref: UnificationXref665
xref: http://identifiers.org/pubmed/16452418
xref: UnificationXref666
left: S-Nitrosoglutathione
left: Amino Acid
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).
comment: Authored: Stephan, R, 2011-01-10
right: L-Glutamyl amino acid
right: S-Nitroso-L-cysteinylglycine

SodB gets secreted
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref698
xref: http://identifiers.org/pubmed/12675804
xref: UnificationXref697
left: SodB
comment: Superoxide dismutase SodB is secreted via the Sec transport complex (Braunstein et al. 2003).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: SodB

SodB reduces superoxide to H2O2
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.15.1.1
xref: UnificationXref708
xref: UnificationXref707
xref: http://identifiers.org/pubmed/1904126
participant stoichiometry: Stoichiometry99
participant stoichiometry: Stoichiometry98
left: proton
left: SO2.-
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Iron-containing superoxide dismutase is localized both within and without the bacterium where it catalyzes the reduction of superoxide (Zhang et al. 1991).
comment: Authored: Stephan, R, 2011-01-10
right: Oxygen
right: Hydrogen peroxide

UnificationXref59
type: UnificationXref
id: 879313
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879313

SodC reduces superoxide to H2O2
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.15.1.1
xref: http://identifiers.org/pubmed/9849904
xref: UnificationXref717
xref: UnificationXref718
participant stoichiometry: Stoichiometry103
participant stoichiometry: Stoichiometry102
left: proton
left: SO2.-
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Copper-containing superoxide dismutase is localized in the plasma membrane of the bacterium where it catalyzes the reduction of superoxide (Wu et al. 1998).
comment: Authored: Stephan, R, 2011-01-10
right: Oxygen
right: Hydrogen peroxide

UnificationXref58
type: UnificationXref
id: CHEBI:52285
db: ChEBI

1,4-alpha-D-Glucan
type: SmallMoleculeReference
name: (1,4-alpha-D-Glucosyl)n-1
name: (1,4-alpha-D-Glucosyl)n
name: 4-{(1,4)-alpha-D-Glucosyl}(n-1)-D-glucose
name: (1,4-alpha-D-Glucosyl)n+1
name: (1,4-alpha-D-Glucosyl)n [ChEBI:138]
xref: UnificationXref217

MsrA/B reduces peptide-methionine S/R-sulfoxides
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.4.11
xref: UnificationXref648
xref: http://identifiers.org/pubmed/11481433
xref: UnificationXref649
xref: http://identifiers.org/pubmed/19040639
left: TrxA
left: Peptide methionine sulfoxide
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: MsrA and MsrB are enzymes that can both reduce the S- and R-stereoisomers of (peptidyl-) methionine sulfoxide. The exact nature of the accompanying thioredoxin is not settled, but it is predicted to be TrxA. The whole methionine-MsrA/B-thioredoxin-and-reductase system is an important part of NO detoxification in Mtb (St John et al. 2001, Lee et al. 2009).
comment: Authored: Stephan, R, 2011-01-10
right: Peptide-Methionine
right: TrxA(ox.)

CysM
type: Protein
entity reference: Rv1336
data source: Reactome
xref: UnificationXref395
xref: UnificationXref396
feature: FragmentFeature32
cellular location: cytosol
comment: Reactome DB_ID: 936710

http://identifiers.org/pubmed/12626396
type: PublicationXref
id: 12626396
author: Pastuszak, I
author: Pan, YT
author: Elbein, AD
author: Carroll, D
db: Pubmed
title: New insights on trehalose: a multifunctional molecule
source: Glycobiology 13:17R-27R
year: 2003

Mec+
type: Protein
entity reference: MTCY130.19
data source: Reactome
xref: UnificationXref404
xref: UnificationXref405
feature: FragmentFeature33
cellular location: cytosol
comment: Reactome DB_ID: 936660

MetB
type: Protein
entity reference: Rv1079
data source: Reactome
xref: UnificationXref423
xref: UnificationXref422
feature: FragmentFeature34
cellular location: cytosol
comment: Reactome DB_ID: 937149

AroG
type: Protein
entity reference: Rv2178c
data source: Reactome
xref: UnificationXref447
xref: UnificationXref448
feature: FragmentFeature35
cellular location: cytosol
comment: Reactome DB_ID: 964864

AroB
type: Protein
entity reference: UniProt:P9WPX9 aroB
data source: Reactome
xref: UnificationXref460
xref: UnificationXref461
feature: FragmentFeature36
cellular location: cytosol
comment: Reactome DB_ID: 964848

AroQ
type: Protein
entity reference: MTCY159.19
data source: Reactome
xref: UnificationXref468
xref: UnificationXref469
feature: FragmentFeature37
cellular location: cytosol
comment: Reactome DB_ID: 964891

AroE
type: Protein
entity reference: Rv2552c
data source: Reactome
xref: UnificationXref479
xref: UnificationXref478
feature: FragmentFeature38
cellular location: cytosol
comment: Reactome DB_ID: 964887

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref17

Trx(red.)
type: Protein
entity reference: trxA
data source: Reactome
xref: UnificationXref305
xref: UnificationXref304
feature: FragmentFeature20
cellular location: cytosol
comment: Reactome DB_ID: 936674

gene ontology term for cellular process
type: RelationshipTypeVocabulary
xref: UnificationXref100

CysQ
type: Protein
entity reference: UniProt:P9WKJ1 cysQ
data source: Reactome
xref: UnificationXref293
xref: UnificationXref294
feature: FragmentFeature19
cellular location: plasma membrane
comment: Reactome DB_ID: 936577

Catalysis60
type: Catalysis
data source: Reactome
controlled: BfrB stores iron
control type: ACTIVATION
xref: RelationshipXref77
xref: RelationshipXref122
controller: BfrB complex

UnificationXref60
type: UnificationXref
id: REACT_27547
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27547.2

UnificationXref61
type: UnificationXref
id: CHEBI:29888
db: ChEBI

UnificationXref62
type: UnificationXref
id: 111294
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294

UnificationXref63
type: UnificationXref
id: REACT_5692
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5692.2

UnificationXref64
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Carboxymycobactin and mycobactin exchange their iron load
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/22232695
xref: UnificationXref831
xref: UnificationXref830
left: Carboxymycobactin:Fe3+
left: Mycobactin
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Carboxymycobactin and mycobactin exchange their iron loads. This interplay between polar and nonpolar siderophore is unique to Mtb. However, mycobactin can gather iron from nonpolar regions of the host cell by itself too (Madigan et al. 2012).
comment: Authored: Stephan, R, 2011-01-10
right: Mycobactin:Fe3+
right: Carboxymycobactin

UnificationXref65
type: UnificationXref
id: 76577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76577

Carboxymycobactin binds iron from lactoferrin
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref825
xref: http://identifiers.org/pubmed/22232695
xref: UnificationXref826
participant stoichiometry: Stoichiometry121
participant stoichiometry: Stoichiometry120
participant stoichiometry: Stoichiometry119
left: Carboxymycobactin
left: Lactoferrin (loaded)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Since bacterial siderophores bind iron with much greater affinity, they can scavenge iron ions from loaded lactoferrin (Madigan et al. 2012).
comment: Authored: Stephan, R, 2011-01-10
right: Lactoferrin
right: Carboxymycobactin:Fe3+
right: Carbonate (2-)

UnificationXref66
type: UnificationXref
id: REACT_2677
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2677.2

Mycobactin is exported
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref810
xref: http://identifiers.org/pubmed/22232695
xref: UnificationXref809
xref: RelationshipXref116
left: Mycobactin
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
comment: Mycobactin is the lipophilic siderophore of Mtb. After export into the periplasmic space, it localizes to the bacterium's cell wall. The responsible transporter activity is still unknown (Madigan et al. 2012).
right: Mycobactin

UnificationXref67
type: UnificationXref
id: P9WJM9
db: UniProt

Carboxymycobactin gets secreted
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref801
xref: UnificationXref802
xref: http://identifiers.org/pubmed/22232695
left: Carboxymycobactin
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Carboxymycobactin is the more polar siderophore of Mtb and it is localized, after its secretion, in the phagosomal lumen. The transporters for export and secretion of this molecule are still unknown (Madigan et al. 2012).
comment: Authored: Stephan, R, 2011-01-10
right: Carboxymycobactin

UnificationXref68
type: UnificationXref
id: 879269
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879269

TrxA/B1 reactivates Tpx
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/14871480
xref: UnificationXref784
xref: UnificationXref785
left: Tpx(ox.)
left: TrxA/B1
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The Tpx peroxiredoxin is reactivated by either TrxA or TrxB1 (Jaeger et al. 2006).
comment: Authored: Stephan, R, 2011-01-10
right: Tpx
right: TrxA/B1 (ox.)

Homo sapiens
type: BioSource
xref: UnificationXref814

Fgd1 reactivates F420
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.1
xref: UnificationXref792
xref: UnificationXref793
xref: http://identifiers.org/pubmed/18434308
left: alpha-D-Glucose 6-phosphate
left: cofactor F420 (ox.)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The enzyme in Mtb known to reduce F420 is the glucose-6-phosphate dehydrogenase Fgd1 (Bashiri et al. 2008).
comment: Authored: Stephan, R, 2011-01-10
right: cofactor F420 (red.)
right: D-Glucono-1,5-lactone 6-phosphate

UnificationXref69
type: UnificationXref
id: REACT_27929
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27929.1

TrxA reactivates AhpC
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/14871480
xref: UnificationXref766
xref: UnificationXref767
left: TrxA
left: AhpC(ox.)
comment: The peroxiredoxin AhpC can be alternatively reactivated by TrxA (Jaeger et al. 2004).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: TrxA(ox.)
right: AhpC

TrxB reactivates TrxA
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.1.9
xref: UnificationXref773
xref: http://identifiers.org/pubmed/14871480
xref: UnificationXref774
left: NADPH
left: TrxA(ox.)
left: proton
comment: TrxB is an NADPH-dependent thioredoxin reductase that reactivates TrxA (Jaeger et al. 2006).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: TrxA
right: NADP+

DlaT reactivates AhpD
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/11799204
xref: UnificationXref755
xref: UnificationXref754
left: dlaT
left: AhpD(ox.)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from Lpd, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
comment: Authored: Stephan, R, 2011-01-10
right: AhpD
right: dlaT(ox.)

Lpd reactivates dlaT
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.8.1.4
xref: http://identifiers.org/pubmed/11799204
xref: UnificationXref764
xref: UnificationXref765
left: dlaT(ox.)
left: NADH
left: proton
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from Lpd, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
comment: Authored: Stephan, R, 2011-01-10
right: dlaT
right: DPN

Fdx
type: Protein
entity reference: MTCY39.10
data source: Reactome
xref: UnificationXref325
xref: UnificationXref326
feature: FragmentFeature23
cellular location: cytosol
comment: Reactome DB_ID: 937262

Sir
type: Protein
entity reference: sir
data source: Reactome
xref: UnificationXref341
xref: UnificationXref342
feature: FragmentFeature24
cellular location: cytosol
comment: Reactome DB_ID: 936705

TrxA(ox.)
type: Protein
entity reference: trxA
data source: Reactome
xref: UnificationXref308
xref: UnificationXref307
feature: FragmentFeature21
feature: ModificationFeature1
feature: ModificationFeature2
cellular location: cytosol
comment: Reactome DB_ID: 1222293

CysH
type: Protein
entity reference: UniProt:P9WIK3 cysH
data source: Reactome
xref: UnificationXref315
xref: UnificationXref316
feature: FragmentFeature22
cellular location: cytosol
comment: Reactome DB_ID: 936694

CysK2
type: Protein
entity reference: UniProt:Q79FV4 cysK2
data source: Reactome
xref: UnificationXref370
xref: UnificationXref369
feature: FragmentFeature27
cellular location: cytosol
comment: Reactome DB_ID: 936682

CysO
type: Protein
entity reference: cfp10A
data source: Reactome
xref: UnificationXref379
xref: UnificationXref378
feature: FragmentFeature28
cellular location: cytosol
comment: Reactome DB_ID: 936619

CysE
type: Protein
entity reference: cysE
data source: Reactome
xref: UnificationXref355
xref: UnificationXref354
feature: FragmentFeature25
cellular location: cytosol
comment: Reactome DB_ID: 936604

CysK1
type: Protein
entity reference: cysK
data source: Reactome
xref: UnificationXref363
xref: UnificationXref362
feature: FragmentFeature26
cellular location: cytosol
comment: Reactome DB_ID: 936587

MsrA/B
type: Protein
data source: Reactome
member physical entity: MsrB
member physical entity: MsrA
xref: UnificationXref647
xref: UnificationXref646
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1243099

TrxA
type: Protein
entity reference: trxA
data source: Reactome
xref: UnificationXref634
xref: UnificationXref635
feature: FragmentFeature50
cellular location: cytosol
comment: Reactome DB_ID: 1222488

MsrB
type: Protein
entity reference: MT2748
data source: Reactome
xref: UnificationXref644
xref: UnificationXref645
feature: FragmentFeature52
cellular location: cytosol
comment: Reactome DB_ID: 1222694

MsrA
type: Protein
entity reference: msrA
data source: Reactome
xref: UnificationXref641
xref: UnificationXref642
feature: FragmentFeature51
cellular location: cytosol
comment: Reactome DB_ID: 1222319

Tpx(ox.)
type: Protein
entity reference: MTCY09F9.32c
data source: Reactome
xref: UnificationXref619
xref: UnificationXref620
feature: FragmentFeature49
feature: ModificationFeature9
feature: ModificationFeature8
cellular location: cytosol
comment: Reactome DB_ID: 1222496

UnificationXref34
type: UnificationXref
id: REACT_27575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27575.1

DHQ from DAHP dephosphorylation
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.3.4
xref: http://identifiers.org/pubmed/17586643
xref: UnificationXref462
xref: UnificationXref463
left: NADH
left: DAHP(3-)
comment: Authored: Stephan, R, 2010-09-13
comment: Cyclization and dephosphorylation of DAHP, catalyzed by AroB, establishes the C6 ring in the pathway which is then only modified in the remaining five reactions (Mendonca et al, 2007).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: 3-Dehydroquinate
right: Phosphate
right: DPN
right: proton

UnificationXref35
type: UnificationXref
id: 879298
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879298

DHAP from Ery4P and PEP
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.54
xref: http://identifiers.org/pubmed/15721768
xref: http://identifiers.org/pubmed/16288916
xref: UnificationXref454
xref: UnificationXref453
left: Water
left: D-Erythrose 4-phosphate
left: Phosphoenolpyruvic acid
comment: Authored: Stephan, R, 2010-09-13
comment: The first committed step in the biosynthesis of chorismate is the fusion of D-erythrose-4-phosphate with phosphoenolpyruvate, catalyzed by AroG (Rizzi et al, 2005; Webby et al, 2005).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: DAHP(3-)

(-)-3-dehydroquinate
type: SmallMoleculeReference
name: 3-dehydroquinate
name: 5-Dehydroquinate
name: 3-dehydroquinate [ChEBI:32364]
xref: UnificationXref456

UnificationXref32
type: UnificationXref
id: P9WMY7
db: UniProt

Shikimate results from hydration of DHS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.1.1.25
xref: UnificationXref482
xref: http://identifiers.org/pubmed/16298142
xref: http://identifiers.org/pubmed/12356471
xref: UnificationXref483
left: 3-Dehydroshikimate
left: NADPH
left: proton
comment: Authored: Stephan, R, 2010-09-13
comment: Edited: Jassal, B, 2011-02-16
comment: The dimeric form of AroE catalyzes the hydration of dehydroshikimate. The reaction is reversible with high efficiency (Magalhaes et al, 2002; Fonseca et al, 2006).
comment: Reviewed: Warner, D, 2010-11-25
right: Shikimate
right: NADP+

UnificationXref33
type: UnificationXref
id: 879291
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879291

Dehydratation of DHQ yields DHS
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.1.10
xref: UnificationXref473
xref: UnificationXref472
xref: http://identifiers.org/pubmed/1329726
left: 3-Dehydroquinate
comment: Authored: Stephan, R, 2010-09-13
comment: AroQ, which catalyzes the dehydratation of 3-dehydroquinate (DHQ) to 3-dehydroshikimate (DHS), is a type II DHQ dehydratase. Unlike fungi DHQ dehydratases, AroQ doesn't take part in catabolism reactions (Moore et al, 1992).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Water
right: 3-Dehydroshikimate

UnificationXref30
type: UnificationXref
id: 110096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110096

EPSP from shikimate 3-phosphate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.19
xref: UnificationXref500
xref: UnificationXref501
xref: http://identifiers.org/pubmed/2123856
left: Shikimate 3-phosphate
left: Phosphoenolpyruvic acid
comment: Authored: Stephan, R, 2010-09-13
comment: Condensation with cleavage of one phosphate group of shikimate 3-phosphate and phosphoenolpyruvate to EPSP is catalyzed by AroA (Garbe et al, 1990).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: EPSP(4-)

UnificationXref31
type: UnificationXref
id: REACT_2602
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2602.2

Phosphorylation of shikimate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.7.1.71
xref: UnificationXref493
xref: UnificationXref492
xref: http://identifiers.org/pubmed/11483005
left: Adenosine 5'-triphosphate
left: Shikimate
comment: Authored: Stephan, R, 2010-09-13
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Shikimate kinase (AroK) phosphorylates shikimate to shikimate 3-phosphate, using ATP (Oliveira et al, 2001).
right: Shikimate 3-phosphate
right: Adenosine 5'-diphosphate

Dephosphorylation of EPSP yields chorismate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 4.2.3.5
xref: http://identifiers.org/pubmed/18445278
xref: UnificationXref514
xref: UnificationXref513
left: EPSP(4-)
comment: Authored: Stephan, R, 2010-09-13
comment: Edited: Jassal, B, 2011-02-16
comment: AroF in complex with reduced FMN catalyzes the dehydration and phosphate cleavage of EPSP, yielding chorismate. The cofactor FMN is reduced by NADPH which makes the enzyme stable in aerobic conditions and is known from similar fungal enzymes (Ely et al, 2008).
comment: Reviewed: Warner, D, 2010-11-25
right: Phosphate
right: Chorismate

UnificationXref39
type: UnificationXref
id: REACT_27562
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27562.1

UnificationXref38
type: UnificationXref
id: 879332
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879332

OPS is added to the carrier sulfide
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.5.1.65
xref: UnificationXref402
xref: UnificationXref401
xref: http://identifiers.org/pubmed/18842002
xref: http://identifiers.org/pubmed/18799456
left: O-phospho-L-serine
left: CysO-COSH
comment: Similar to thiamine or pterine biosynthesis, the sulfide carrier protein CysO serves as substrate to the pyridoxal phosphate-dependent, dimeric CysM which transfers O-phosphoserine onto the sulfur (OLeary et al, 2008; Agren et al, 2008).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Authored: Stephan, R, 2010-08-12
right: Phosphate
right: CysO-CO-Cys

UnificationXref37
type: UnificationXref
id: CHEBI:52442
db: ChEBI

cleavage of L-cysteine from carrier protein
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref408
xref: http://identifiers.org/pubmed/16104727
xref: UnificationXref409
left: Water
left: CysO-CO-Cys
comment: Authored: Stephan, R, 2010-08-16
comment: After serine was transferred onto its sulfhydryl group, a metallopeptidase cleaves the cysteine molecule from the sulfur carrier protein (Burns et al, 2005).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: L-2-amino-3-mercaptopropionic acid
right: CysO

UnificationXref36
type: UnificationXref
id: REACT_27245
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27245.1

Cysteine from cystathionine and vice versa
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 4.4.1.1
xref: UnificationXref429
xref: UnificationXref428
xref: http://identifiers.org/pubmed/15576367
left: Water
left: cystathionine
comment: Authored: Stephan, R, 2010-08-19
comment: The pyridoxalphosphate-dependent enzyme MetB not only catalyzes destruction of cystathonine to cysteine but also the transfer of homoserine onto cysteine to yield cystathione from O-succinyl-L-homoserine. This ensures that cysteine and methionine can be interconverted when the need arises. (Wheeler et al, 2005)
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
right: L-2-amino-3-mercaptopropionic acid
right: Ammonia
right: 2-oxobutanoic acid

SecD
type: Protein
entity reference: secD
data source: Reactome
xref: UnificationXref679
xref: UnificationXref678
feature: FragmentFeature57
cellular location: plasma membrane
comment: Reactome DB_ID: 1222450

GgtA
type: Protein
entity reference: Rv0773c
data source: Reactome
xref: UnificationXref663
xref: UnificationXref664
feature: FragmentFeature53
cellular location: periplasmic space
comment: Reactome DB_ID: 1222419

SodB
type: Protein
entity reference: sod
data source: Reactome
xref: UnificationXref671
xref: UnificationXref670
feature: FragmentFeature54
cellular location: cytosol
comment: Reactome DB_ID: 1222623

SodB
type: Protein
entity reference: sod
data source: Reactome
xref: UnificationXref673
xref: UnificationXref672
feature: FragmentFeature55
cellular location: periplasmic space
comment: Reactome DB_ID: 1222527

SecA2
type: Protein
entity reference: MTCY1A11.22c
data source: Reactome
xref: UnificationXref676
xref: UnificationXref675
feature: FragmentFeature56
cellular location: cytosol
comment: Reactome DB_ID: 1222457

BfrA
type: Protein
entity reference: Rv1876
data source: Reactome
xref: UnificationXref543
xref: UnificationXref544
feature: FragmentFeature42
cellular location: plasma membrane
comment: Reactome DB_ID: 1222562

AroC
type: Protein
entity reference: UniProt:P9WPY1 aroC
data source: Reactome
xref: UnificationXref510
xref: UnificationXref509
feature: FragmentFeature41
cellular location: cytosol
comment: Reactome DB_ID: 964883

AroA
type: Protein
entity reference: Rv3227
data source: Reactome
xref: UnificationXref499
xref: UnificationXref498
feature: FragmentFeature40
cellular location: cytosol
comment: Reactome DB_ID: 964880

AroK
type: Protein
entity reference: MTCY159.17
data source: Reactome
xref: UnificationXref488
xref: UnificationXref489
feature: FragmentFeature39
cellular location: cytosol
comment: Reactome DB_ID: 964918

UnificationXref43
type: UnificationXref
id: 1773
db: NCBI Taxonomy

Peroxynitrite is reduced to nitrite by Tpx
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.15
xref: http://identifiers.org/pubmed/14871480
xref: http://identifiers.org/pubmed/16884737
xref: UnificationXref624
xref: UnificationXref623
participant stoichiometry: Stoichiometry83
participant stoichiometry: Stoichiometry84
participant stoichiometry: Stoichiometry85
participant stoichiometry: Stoichiometry86
participant stoichiometry: Stoichiometry87
left: Peroxynitrite
left: Tpx
comment: Tpx, like AhpC, is a peroxiredoxin with alkylhydroperoxidase, peroxidase, and peroxynitritase activities. Peroxynitrite is detoxified to nitrite (Jaeger et al. 2006, Rho et al. 2006).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: Tpx(ox.)
right: Nitrite

UnificationXref44
type: UnificationXref
id: P95189
db: UniProt

Peroxynitrite is reduced by AhpE
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.15
xref: http://identifiers.org/pubmed/19737009
xref: UnificationXref615
xref: UnificationXref614
left: Peroxynitrite
left: AhpE dimer (red.)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The peroxiredoxin AhpE participates in reducing peroxynitrite to nitrite, but how it is recycled back to the reduced form is still unknown (Hugo et al. 2009).
comment: Authored: Schmidt, EE, 2006-02-06 10:50:16
right: Water
right: AhpE dimer (ox.)
right: Nitrite

UnificationXref45
type: UnificationXref
id: 879317
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879317

Peroxynitrite is reduced to nitrite by AhpC
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.11.1.15
xref: UnificationXref604
xref: http://identifiers.org/pubmed/15886207
xref: UnificationXref603
participant stoichiometry: Stoichiometry79
participant stoichiometry: Stoichiometry77
participant stoichiometry: Stoichiometry78
participant stoichiometry: Stoichiometry75
participant stoichiometry: Stoichiometry76
left: Peroxynitrite
left: AhpC
comment: AhpC is an unusual peroxiredoxin - it has three cysteine residues that participate in the reduction of toxic peroxynitrite to nitrite. In a second step, another thioredoxin or the reductase chain AhpD/DlaT/Lpd is needed for reactivation (Guimaraes et al. 2005).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: Nitrite
right: AhpC(ox.)

UnificationXref46
type: UnificationXref
id: REACT_27548
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27548.1

Nitric oxide is oxidized to nitrate
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.14.12.17
xref: http://identifiers.org/pubmed/11959913
xref: UnificationXref594
xref: UnificationXref595
xref: http://identifiers.org/pubmed/12207698
participant stoichiometry: Stoichiometry72
participant stoichiometry: Stoichiometry69
left: NO+
left: GlbN:Heme dimer
left: Oxygen
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).
comment: Authored: Stephan, R, 2011-01-10
right: Nitrate
right: GlbN:Ferriheme dimer

UnificationXref40
type: UnificationXref
id: CHEBI:18367
db: ChEBI

MscR reduces nitrosomycothiol to ammonia
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1
xref: http://identifiers.org/pubmed/12809551
xref: UnificationXref632
xref: UnificationXref633
participant stoichiometry: Stoichiometry90
participant stoichiometry: Stoichiometry89
left: nitrosomycothiol
left: mycothiol
left: NADH
left: proton
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
comment: MscR is an alcohol dehydrogenase that can probably reduce nitrosomycothiol with the help of NADH/H+ reducing equivalents to the sulfinamide which then presumably decomposes to the thione and ammonia (Vogt et al. 2003).
right: Water
right: DPN
right: mycothione
right: Ammonia

UnificationXref41
type: UnificationXref
id: 29372
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

Mycothiol scavenges nitrosyl
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref629
xref: http://identifiers.org/pubmed/17638697
xref: UnificationXref628
left: NO+
left: mycothiol
comment: Nitrosyl is scavenged by mycothiol (MSH), which is functionally analogous to glutathione, which mycobacteria do not possess (Miller et al. 2007).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: S-Nitrosomycothiol
right: proton

UnificationXref42
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

UnificationXref48
type: UnificationXref
id: REACT_27149
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27149.1

Ferritin takes up and mineralizes iron
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.16.3.1
xref: UnificationXref558
xref: UnificationXref557
participant stoichiometry: Stoichiometry66
left: BfrA complex
left: Fe(III)
comment: Edited: Jassal, B, 2011-02-28
comment: Authored: Stephan, R, 2011-01-10
comment: Bacterioferritin, like ferritin, is a spherical shell-like protein that takes up 48 ferrous iron ions, and subsequently oxidizes and hydrolyzes them for better storage. (Yang et al, 2000)
right: BfrA complex (iron-loaded)

UnificationXref47
type: UnificationXref
id: 879274
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879274

Nitrogen dioxide is reduced to NO by F420
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/19325122
xref: UnificationXref572
xref: UnificationXref571
left: nitrogen dioxide
left: cofactor F420 (red.)
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: The archaeal cofactor F420 reduces toxic nitrogen dioxide that can be produced when NO and oxygen combine. F420 itself is reduced by the enzyme Fgd (Purwantini & Mukhopadyay 2008).
comment: Authored: Stephan, R, 2011-01-10
right: Water
right: NO
right: cofactor F420 (ox.)

Peroxynitrite oxidizes methionine residues
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref530
xref: http://identifiers.org/pubmed/7972029
xref: UnificationXref529
left: Peptide-Methionine
left: Peroxynitrite
left: proton
comment: Peroxynitrite oxidizes methionine residues (Pryor et al. 1994).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: Peptide-Methionine (S)-Sulfoxide
right: Nitrite
right: proton

UnificationXref49
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Hydroperoxyl enters the bacterium
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/11970850
xref: http://identifiers.org/pubmed/16847086
xref: http://identifiers.org/pubmed/10922044
xref: http://identifiers.org/pubmed/15155722
xref: UnificationXref538
xref: UnificationXref537
left: hydroperoxyl
comment: Superoxide can enter the bacterium when acidic conditions apply. Together with a proton it forms the hydroperoxyl radical (Nathan & Shiloh 2000, Zahrt & Deretic 2002, Warner & Mizrahi 2006, Spagnolo et al, 2004).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
right: hydroperoxyl

AhpE (ox.)
type: Protein
entity reference: Rv2238c
data source: Reactome
xref: UnificationXref611
xref: UnificationXref610
feature: ModificationFeature7
feature: FragmentFeature47
cellular location: cytosol
comment: Reactome DB_ID: 1500820

Tpx
type: Protein
entity reference: MTCY09F9.32c
data source: Reactome
xref: UnificationXref618
xref: UnificationXref617
feature: FragmentFeature48
cellular location: cytosol
comment: Reactome DB_ID: 1222392

http://identifiers.org/pubmed/19325122
type: PublicationXref
id: 19325122
author: Mukhopadhyay, B
author: Purwantini, E
db: Pubmed
title: Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage
source: Proc Natl Acad Sci U S A 106:6333-8
year: 2009

AhpC(ox.)
type: Protein
entity reference: ahpC
data source: Reactome
xref: UnificationXref599
xref: UnificationXref600
feature: ModificationFeature5
feature: ModificationFeature6
feature: FragmentFeature45
cellular location: cytosol
comment: Reactome DB_ID: 1222326

AhpE
type: Protein
entity reference: Rv2238c
data source: Reactome
xref: UnificationXref607
xref: UnificationXref606
feature: FragmentFeature46
cellular location: cytosol
comment: Reactome DB_ID: 1500786

GlbN
type: Protein
entity reference: glbN
data source: Reactome
xref: UnificationXref578
xref: UnificationXref577
feature: FragmentFeature43
cellular location: cytosol
comment: Reactome DB_ID: 1222724

AhpC
type: Protein
entity reference: ahpC
data source: Reactome
xref: UnificationXref597
xref: UnificationXref598
feature: FragmentFeature44
cellular location: cytosol
comment: Reactome DB_ID: 1222710