UnificationXref6
type: UnificationXref
id: 29360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

UnificationXref11
type: UnificationXref
id: CHEBI:16886
db: ChEBI

UnificationXref5
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref10
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

UnificationXref8
type: UnificationXref
id: CHEBI:15377
db: ChEBI

UnificationXref13
type: UnificationXref
id: REACT_2377
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2377.2

aminomuconate-semialdehyde dehydrogenase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref21
xref: UnificationXref20
cellular location: cytosol
comment: Reactome DB_ID: 164914

UnificationXref7
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

UnificationXref12
type: UnificationXref
id: 32913
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=32913

UnificationXref15
type: UnificationXref
id: 73473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref2
type: UnificationXref
id: CHEBI:15745
db: ChEBI

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

UnificationXref14
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref1
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref17
type: UnificationXref
id: CHEBI:15378
db: ChEBI

UnificationXref4
type: UnificationXref
id: REACT_3299
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3299.2

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref18
xref: UnificationXref19
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

UnificationXref16
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref3
type: UnificationXref
id: 35181
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=35181

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref14

2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.2.1.32
xref: UnificationXref24
xref: UnificationXref23
xref: http://identifiers.org/pubmed/14275130
left: 2-Aminomuconate 6-semialdehyde
left: Water
left: DPN
comment: Authored: D'Eustachio, P, 2005-07-20 13:46:37
comment: Edited: D'Eustachio, P, 2005-07-20 13:46:37
comment: This reaction has been characterized in vitro using enzyme partially purified from cat liver (Ichiyama et al. 1965). The human event is inferred from the cat one. Neither the cat nor the human protein has been fully purified or sequenced.
right: NADH
right: proton
right: o-Aminomuconate

Same Catalyst Activity
type: RelationshipTypeVocabulary

UnificationXref18
type: UnificationXref
id: 70106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

UnificationXref19
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

UnificationXref9
type: UnificationXref
id: 29356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref5

UnificationXref24
type: UnificationXref
id: REACT_80
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80.4

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref22

UnificationXref23
type: UnificationXref
id: 164926
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=164926

UnificationXref22
type: UnificationXref
id: MI:0355
db: MI

UnificationXref21
type: UnificationXref
id: REACT_5641
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5641.1

RelationshipXref2
type: RelationshipXref
id: 164921
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=164921

RelationshipXref1
type: RelationshipXref
id: GO:0047102
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref20
type: UnificationXref
id: 164914
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=164914

2-Aminomuconate semialdehyde [ChEBI:15745]
type: SmallMoleculeReference
name: 2-Aminomuconate 6-semialdehyde
name: 2-Aminomuconate semialdehyde
xref: UnificationXref2

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref17

2-Aminomuconate 6-semialdehyde
type: SmallMolecule
entity reference: 2-Aminomuconate semialdehyde [ChEBI:15745]
data source: Reactome
name: 2-Aminomuconate semialdehyde
xref: UnificationXref4
xref: UnificationXref3
cellular location: cytosol
comment: Reactome DB_ID: 35181
display name: 2AMA

Catalysis1
type: Catalysis
data source: Reactome
controlled: 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: aminomuconate-semialdehyde dehydrogenase

o-Aminomuconate
type: SmallMoleculeReference
name: 2-Aminomuconate [ChEBI:16886]
name: 2-Aminomuconate
name: 2-Aminomuconic acid
xref: UnificationXref11

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref10
xref: UnificationXref9
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref6
xref: UnificationXref7
cellular location: cytosol
comment: Reactome DB_ID: 29360
display name: NAD

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref15
xref: UnificationXref16
cellular location: cytosol
comment: Reactome DB_ID: 73473

o-Aminomuconate
type: SmallMolecule
entity reference: o-Aminomuconate
data source: Reactome
name: 2-Aminomuconate
name: 2-Aminomuconic acid
xref: UnificationXref13
xref: UnificationXref12
cellular location: cytosol
comment: Reactome DB_ID: 32913
display name: 2AM

Reactome
type: Provenance
comment: http://www.reactome.org

http://identifiers.org/pubmed/14275130
type: PublicationXref
id: 14275130
author: Nakamura, S
author: Hayaishi, Osamu
author: Kawai, H
author: Senoh, S
author: Nishizuka, Yasutomi
author: Honjo, Tasuku
author: Ichiyama, A
db: Pubmed
title: Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymatic formation of alpha-muconic acid from 2-hydroxyanthranilic acid
source: J Biol Chem 240:740-9
year: 1965

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref8