Fre
type: Protein
entity reference: UniProt:P0AEN1 fre
data source: Reactome
xref: UnificationXref55
xref: UnificationXref54
feature: FragmentFeature2
cellular location: cytosol
comment: Reactome DB_ID: 1222430

UnificationXref60
type: UnificationXref
id: REACT_11937
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11937.2

Bfr
type: Protein
entity reference: b3336
data source: Reactome
xref: UnificationXref8
xref: UnificationXref7
feature: FragmentFeature1
cellular location: plasma membrane
comment: Reactome DB_ID: 1222720

UnificationXref61
type: UnificationXref
id: CHEBI:15377
db: ChEBI

PNCA_ECOLI
type: Protein
entity reference: JW1757
data source: Reactome
name: Pyrazinamidase/nicotinamidase
xref: UnificationXref71
xref: UnificationXref72
feature: FragmentFeature3
cellular location: cytosol
comment: Reactome DB_ID: 197272
display name: pncA

UnificationXref56
type: UnificationXref
id: 1222667
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222667

UnificationXref55
type: UnificationXref
id: REACT_201661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201661.1

UnificationXref58
type: UnificationXref
id: CHEBI:17154
db: ChEBI

UnificationXref57
type: UnificationXref
id: REACT_200619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_200619.1

UnificationXref52
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

UnificationXref51
type: UnificationXref
id: 29366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

UnificationXref54
type: UnificationXref
id: 1222430
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222430

UnificationXref53
type: UnificationXref
id: P0AEN1
db: UniProt

UnificationXref59
type: UnificationXref
id: 197277
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197277

iron (ferrous)
type: SmallMoleculeReference
name: iron (ferrous) [ChEBI:18248]
name: Fe2+
name: Fe(II)
name: Fe++
xref: UnificationXref14

http://identifiers.org/pubmed/8436123
type: PublicationXref
id: 8436123
author: Coves, J
author: Fontecave, M
db: Pubmed
title: Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli
source: Eur J Biochem 211:635-41
year: 1993

UnificationXref3
type: UnificationXref
id: 917919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=917919

UnificationXref71
type: UnificationXref
id: 197272
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197272

UnificationXref2
type: UnificationXref
id: CHEBI:17627
db: ChEBI

UnificationXref72
type: UnificationXref
id: REACT_11253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11253.1

UnificationXref1
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref70
type: UnificationXref
id: P21369
db: UniProt

UnificationXref69
type: UnificationXref
id: REACT_3820
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3820.1

UnificationXref68
type: UnificationXref
id: 29382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29382

UnificationXref8
type: UnificationXref
id: REACT_201561
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201561.1

UnificationXref67
type: UnificationXref
id: CHEBI:16134
db: ChEBI

UnificationXref9
type: UnificationXref
id: 1222734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222734

UnificationXref66
type: UnificationXref
id: REACT_11564
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11564.2

UnificationXref6
type: UnificationXref
id: P0ABD3
db: UniProt

UnificationXref65
type: UnificationXref
id: 197230
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197230

UnificationXref7
type: UnificationXref
id: 1222720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222720

UnificationXref64
type: UnificationXref
id: CHEBI:15940
db: ChEBI

UnificationXref4
type: UnificationXref
id: REACT_26823
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26823.1

UnificationXref63
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

UnificationXref5
type: UnificationXref
id: 562
db: NCBI Taxonomy

UnificationXref62
type: UnificationXref
id: 29356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: Gly-tRNA(Gly) [ChEBI:29156]
data source: Reactome
xref: UnificationXref97
xref: UnificationXref98
cellular location: cytosol
comment: Reactome DB_ID: 379784

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: Glu-tRNA(Glu)
data source: Reactome
xref: UnificationXref95
xref: UnificationXref94
cellular location: cytosol
comment: Reactome DB_ID: 379751

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: Ile-tRNA(Ile)
data source: Reactome
xref: UnificationXref104
xref: UnificationXref103
cellular location: cytosol
comment: Reactome DB_ID: 379787

His-tRNA(His)
type: SmallMolecule
entity reference: His-tRNA(His)
data source: Reactome
xref: UnificationXref101
xref: UnificationXref100
cellular location: cytosol
comment: Reactome DB_ID: 379786

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: ChEBI:16047 Lys-tRNA(Lys)
data source: Reactome
xref: UnificationXref110
xref: UnificationXref109
cellular location: cytosol
comment: Reactome DB_ID: 379736

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: ChEBI:16624 Leu-tRNA(Leu)
data source: Reactome
xref: UnificationXref106
xref: UnificationXref107
cellular location: cytosol
comment: Reactome DB_ID: 379757

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: ChEBI:29153 Phe-tRNA(Phe)
data source: Reactome
xref: UnificationXref115
xref: UnificationXref116
cellular location: cytosol
comment: Reactome DB_ID: 379792

Stoichiometry18
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 2.0

Met-tRNA(Met)
type: SmallMolecule
entity reference: Met-tRNA(Met) [ChEBI:16635]
data source: Reactome
xref: UnificationXref112
xref: UnificationXref113
cellular location: cytosol
comment: Reactome DB_ID: 379794

Stoichiometry19
type: Stoichiometry
physical entity: messenger RNA
stoichiometric coefficient: 1.0

Stoichiometry16
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 2.0

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: Pro-tRNA(Pro)
data source: Reactome
xref: UnificationXref119
xref: UnificationXref118
cellular location: cytosol
comment: Reactome DB_ID: 379746

Stoichiometry17
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry14
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

Stoichiometry15
type: Stoichiometry
physical entity: Enterobactin
stoichiometric coefficient: 2.0

Stoichiometry12
type: Stoichiometry
physical entity: peptidyl-tRNA with elongated peptide
stoichiometric coefficient: 1.0

UnificationXref80
type: UnificationXref
id: REACT_15727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15727.1

Stoichiometry13
type: Stoichiometry
physical entity: Enterobactin:Fe3+
stoichiometric coefficient: 2.0

UnificationXref81
type: UnificationXref
id: CHEBI:29265
db: ChEBI

Stoichiometry10
type: Stoichiometry
physical entity: messenger RNA
stoichiometric coefficient: 1.0

UnificationXref82
type: UnificationXref
id: 379728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379728

Stoichiometry11
type: Stoichiometry
physical entity: 70S ribosome
stoichiometric coefficient: 1.0

UnificationXref83
type: UnificationXref
id: REACT_15840
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15840.1

Stoichiometry20
type: Stoichiometry
physical entity: Aminoacyl-tRNA
stoichiometric coefficient: 1.0

UnificationXref74
type: UnificationXref
id: REACT_11101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11101.2

UnificationXref73
type: UnificationXref
id: 197190
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197190

UnificationXref76
type: UnificationXref
id: 379700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379700

UnificationXref75
type: UnificationXref
id: CHEBI:17732
db: ChEBI

UnificationXref78
type: UnificationXref
id: CHEBI:18366
db: ChEBI

UnificationXref77
type: UnificationXref
id: REACT_17687
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17687.1

UnificationXref79
type: UnificationXref
id: 379720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379720

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: Gln-tRNA(Gln) [ChEBI:29166]
data source: Reactome
xref: UnificationXref91
xref: UnificationXref92
cellular location: cytosol
comment: Reactome DB_ID: 379772

Ammonia
type: SmallMolecule
entity reference: Ammonia
data source: Reactome
xref: UnificationXref69
xref: UnificationXref68
cellular location: cytosol
comment: Reactome DB_ID: 29382
display name: NH3

Nicotinate
type: SmallMolecule
entity reference: Nicotinate [ChEBI:7559]
data source: Reactome
name: Nicotinic acid
name: Niacin
xref: UnificationXref66
xref: UnificationXref65
cellular location: cytosol
comment: Reactome DB_ID: 197230
display name: NCA

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref63
xref: UnificationXref62
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

Nicotinamide
type: SmallMolecule
entity reference: Nicotinamide
data source: Reactome
xref: UnificationXref60
xref: UnificationXref59
cellular location: cytosol
comment: Reactome DB_ID: 197277
display name: NAM

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: ChEBI:29265 Asn-tRNA(Asn)
data source: Reactome
xref: UnificationXref82
xref: UnificationXref83
cellular location: cytosol
comment: Reactome DB_ID: 379728

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: Arg-tRNA(Arg)
data source: Reactome
xref: UnificationXref79
xref: UnificationXref80
cellular location: cytosol
comment: Reactome DB_ID: 379720

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: ChEBI:17732 Ala-tRNA(Ala)
data source: Reactome
xref: UnificationXref76
xref: UnificationXref77
cellular location: cytosol
comment: Reactome DB_ID: 379700

Aminoacyl-tRNA
type: SmallMolecule
data source: Reactome
member physical entity: Gly-tRNA(Gly)
member physical entity: Glu-tRNA(Glu)
member physical entity: Ile-tRNA(Ile)
member physical entity: His-tRNA(His)
member physical entity: Asn-tRNA(Asn)
member physical entity: Lys-tRNA(Lys)
member physical entity: Arg-tRNA(Arg)
member physical entity: Leu-tRNA(Leu)
member physical entity: Phe-tRNA(Phe)
member physical entity: Ala-tRNA(Ala)
member physical entity: Met-tRNA(Met)
member physical entity: Pro-tRNA(Pro)
member physical entity: Cys-tRNA(Cys)
member physical entity: Asp-tRNA(Asp)
member physical entity: Val-tRNA(Val)
member physical entity: Trp-tRNA(Trp)
member physical entity: Tyr-tRNA(Tyr)
member physical entity: Thr-tRNA(Thr)
member physical entity: Ser-tRNA(Ser)
member physical entity: Gln-tRNA(Gln)
xref: UnificationXref135
xref: UnificationXref136
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 37001

UnificationXref90
type: UnificationXref
id: CHEBI:29166
db: ChEBI

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: ChEBI:29152 Cys-tRNA(Cys)
data source: Reactome
xref: UnificationXref89
xref: UnificationXref88
cellular location: cytosol
comment: Reactome DB_ID: 379719

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: ChEBI:29158 Asp-tRNA(Asp)
data source: Reactome
xref: UnificationXref86
xref: UnificationXref85
cellular location: cytosol
comment: Reactome DB_ID: 379707

Stoichiometry21
type: Stoichiometry
physical entity: 70S ribosome
stoichiometric coefficient: 1.0

UnificationXref93
type: UnificationXref
id: CHEBI:29157
db: ChEBI

Stoichiometry22
type: Stoichiometry
physical entity: fMet-tRNA
stoichiometric coefficient: 1.0

UnificationXref94
type: UnificationXref
id: 379751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379751

UnificationXref91
type: UnificationXref
id: 379772
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379772

UnificationXref92
type: UnificationXref
id: REACT_15566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15566.1

UnificationXref87
type: UnificationXref
id: CHEBI:29152
db: ChEBI

UnificationXref86
type: UnificationXref
id: REACT_15677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15677.1

UnificationXref85
type: UnificationXref
id: 379707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379707

UnificationXref84
type: UnificationXref
id: CHEBI:29158
db: ChEBI

UnificationXref89
type: UnificationXref
id: REACT_15780
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15780.1

UnificationXref88
type: UnificationXref
id: 379719
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379719

Protoheme
type: SmallMoleculeReference
name: Ferroheme
name: Heme
name: Haem
name: Heme [ChEBI:17627]
xref: UnificationXref2

fMet-tRNA
type: PhysicalEntity
data source: Reactome
name: methionyl initiator tRNA
name: Met-tRNAf
xref: UnificationXref137
xref: UnificationXref138
cellular location: cytosol
display name: Met-tRNAi
comment: Reactome DB_ID: 72393

peptidyl-tRNA with elongated peptide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref31
xref: UnificationXref30
cellular location: cytosol
comment: Reactome DB_ID: 141678

ChEBI:16047 Lys-tRNA(Lys)
type: SmallMoleculeReference
name: Lys-tRNA(Lys)
xref: UnificationXref108

70S ribosome
type: PhysicalEntity
data source: Reactome
xref: UnificationXref28
xref: UnificationXref29
cellular location: cytosol
comment: Reactome DB_ID: 159881

UniProt:P0AEN1 fre
type: ProteinReference
name: JW3820
name: ubiB
name: fsrC
name: b3844
name: flrD
name: fre
name: fadI
xref: UnificationXref53
comment: FUNCTION Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator.CATALYTIC ACTIVITY Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H.CATALYTIC ACTIVITY 2 cob(II)alamin + NAD(+) = 2 aquacob(III)alamin + NADH.SUBUNIT Monomer.SIMILARITY Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.SIMILARITY Contains 1 FAD-binding FR-type domain.CAUTION Was originally (PubMed:1379743) assigned to be ubiB.
organism: Escherichia coli

RelationshipXref5
type: RelationshipXref
id: GO:0008936
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref6
type: RelationshipXref
id: 197229
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197229

RelationshipXref3
type: RelationshipXref
id: GO:0052873
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref4
type: RelationshipXref
id: 1222576
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222576

RelationshipXref1
type: RelationshipXref
id: GO:0004322
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

70S:Met-tRNAi:mRNA:aa-tRNA
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry20
component stoichiometry: Stoichiometry19
component stoichiometry: Stoichiometry21
component stoichiometry: Stoichiometry22
component: messenger RNA
component: Aminoacyl-tRNA
component: fMet-tRNA
component: 70S ribosome
xref: UnificationXref140
xref: UnificationXref139
cellular location: cytosol
comment: Reactome DB_ID: 159889

RelationshipXref2
type: RelationshipXref
id: 1222616
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222616

Elongation complex with growing peptide chain
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry7
component stoichiometry: Stoichiometry8
component stoichiometry: Stoichiometry9
component: messenger RNA
component: peptidyl-tRNA with elongated peptide
component: 70S ribosome
xref: UnificationXref32
xref: UnificationXref33
cellular location: cytosol
comment: Reactome DB_ID: 159880

70S:mRNA:peptidyl-tRNA with elongating peptide
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry12
component stoichiometry: Stoichiometry10
component stoichiometry: Stoichiometry11
component: messenger RNA
component: peptidyl-tRNA with elongated peptide
component: 70S ribosome
xref: UnificationXref35
xref: UnificationXref34
cellular location: cytosol
comment: Reactome DB_ID: 159891

UnificationXref99
type: UnificationXref
id: CHEBI:29155
db: ChEBI

http://identifiers.org/pubmed/10769150
type: PublicationXref
id: 10769150
author: Chasteen, ND
author: Thomson, AJ
author: Yang, X
author: Moore, GR
author: Le Brun, NE
db: Pubmed
title: The iron oxidation and hydrolysis chemistry of Escherichia coli bacterioferritin
source: Biochemistry 39:4915-23
year: 2000

UnificationXref95
type: UnificationXref
id: REACT_16052
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16052.1

UnificationXref96
type: UnificationXref
id: CHEBI:29156
db: ChEBI

UnificationXref97
type: UnificationXref
id: 379784
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379784

UnificationXref98
type: UnificationXref
id: REACT_18164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18164.1

Fe-enterobactin [ChEBI:4993]
type: SmallMoleculeReference
name: Fe-enterochlin
name: Fe-enterobactin
xref: UnificationXref38

Val-tRNA(Val)
type: SmallMolecule
entity reference: Val-tRNA(Val)
data source: Reactome
xref: UnificationXref133
xref: UnificationXref134
cellular location: cytosol
comment: Reactome DB_ID: 379790

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: ChEBI:29159 Trp-tRNA(Trp)
data source: Reactome
xref: UnificationXref128
xref: UnificationXref127
cellular location: cytosol
comment: Reactome DB_ID: 379765

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: Tyr-tRNA(Tyr)
data source: Reactome
xref: UnificationXref130
xref: UnificationXref131
cellular location: cytosol
comment: Reactome DB_ID: 379785

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: Thr-tRNA(Thr)
data source: Reactome
xref: UnificationXref124
xref: UnificationXref125
cellular location: cytosol
comment: Reactome DB_ID: 379783

Stoichiometry5
type: Stoichiometry
physical entity: Bfr dimer
stoichiometric coefficient: 12.0

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: Ser-tRNA(Ser)
data source: Reactome
xref: UnificationXref121
xref: UnificationXref122
cellular location: cytosol
comment: Reactome DB_ID: 379738

Stoichiometry6
type: Stoichiometry
physical entity: iron (ferric)
stoichiometric coefficient: 48.0

Stoichiometry7
type: Stoichiometry
physical entity: messenger RNA
stoichiometric coefficient: 1.0

Stoichiometry8
type: Stoichiometry
physical entity: 70S ribosome
stoichiometric coefficient: 1.0

Stoichiometry1
type: Stoichiometry
physical entity: heme
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
name: NADPH [ChEBI:16474]
name: TPNH
xref: UnificationXref41

Stoichiometry2
type: Stoichiometry
physical entity: Bfr
stoichiometric coefficient: 2.0

Stoichiometry3
type: Stoichiometry
physical entity: Bfr dimer
stoichiometric coefficient: 12.0

Stoichiometry4
type: Stoichiometry
physical entity: Fe(III)
stoichiometric coefficient: 48.0

E.Coli deamination of nicotinamide
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 3.5.1.19
xref: UnificationXref74
xref: UnificationXref73
xref: http://identifiers.org/pubmed/8726014
left: Water
left: Nicotinamide
comment: Nicotinamidase deaminates nicotinamide to nicotinate (Frothingham et al. 1996).
right: Ammonia
right: Nicotinate

Iron is reduced and separates from enterobactin
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref56
xref: UnificationXref57
xref: http://identifiers.org/pubmed/8436123
participant stoichiometry: Stoichiometry18
participant stoichiometry: Stoichiometry16
participant stoichiometry: Stoichiometry17
participant stoichiometry: Stoichiometry14
participant stoichiometry: Stoichiometry15
participant stoichiometry: Stoichiometry13
left: NADPH
left: Enterobactin:Fe3+
comment: Edited: Jassal, B, 2011-02-28
comment: The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
comment: Authored: Stephan, R, 2011-01-10
right: proton
right: Enterobactin
right: Fe(III)
right: NADP+

Peptide transfer from P-site tRNA to the A-site tRNA
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/12297040
xref: http://identifiers.org/pubmed/4921478
xref: UnificationXref142
xref: UnificationXref141
left: 70S:Met-tRNAi:mRNA:aa-tRNA
comment: At the beginning of this reaction, 1 molecule of '70S:Met-tRNAi:mRNA:aa-tRNA' is present. At the end of this reaction, 1 molecule of 'Elongation complex with growing peptide chain' is present.
right: Elongation complex with growing peptide chain

Stoichiometry9
type: Stoichiometry
physical entity: peptidyl-tRNA with elongated peptide
stoichiometric coefficient: 1.0

Translocation of ribosome by 3 bases in the 3' direction
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref37
xref: http://identifiers.org/pubmed/1703007
xref: http://identifiers.org/pubmed/4921478
xref: http://identifiers.org/pubmed/7027051
xref: UnificationXref36
left: Elongation complex with growing peptide chain
comment: At the beginning of this reaction, 1 molecule of 'Elongation complex with growing peptide chain' is present. At the end of this reaction, 1 molecule of '70S:mRNA:peptidyl-tRNA with elongating peptide' is present.
right: 70S:mRNA:peptidyl-tRNA with elongating peptide

Ferritin takes up and mineralizes iron
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 1.16.3.1
xref: UnificationXref23
xref: UnificationXref24
xref: http://identifiers.org/pubmed/10769150
participant stoichiometry: Stoichiometry4
left: Fe(III)
left: Bfr complex
comment: Authored: Stephan, R, 2011-01-10
comment: Bacterioferritin, like ferritin, is a spherical shell-like protein that takes up 48 ferrous iron ions, and subsequently oxidizes and hydrolyzes them for better storage. (Yang et al, 2000)
right: Bfr complex (iron-loaded)

cytosol
type: CellularLocationVocabulary
xref: UnificationXref13

messenger RNA [ChEBI:33699]
type: SmallMoleculeReference
name: messenger RNA
name: template RNA
name: mRNA
xref: UnificationXref25

Escherichia coli
type: BioSource
xref: UnificationXref5

ChEBI:29152 Cys-tRNA(Cys)
type: SmallMoleculeReference
name: Cys-tRNA(Cys)
xref: UnificationXref87

http://identifiers.org/pubmed/12297040
type: PublicationXref
id: 12297040
author: Green, R
author: Lorsch, JR
db: Pubmed
title: The path to perdition is paved with protons
source: Cell 110:665-8
year: 2002

b3336
type: ProteinReference
name: UniProt:P0ABD3 bfr
name: bfr
name: JW3298
xref: UnificationXref6
comment: MISCELLANEOUS The internal surface iron site that binds iron 3 is important for the mineralization phase but not for Fe(2+) binding and oxidation at the ferroxidase center.SIMILARITY Belongs to the bacterioferritin family.SIMILARITY Contains 1 ferritin-like diiron domain.
organism: Escherichia coli

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref81

Bfr complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry3
component: Bfr dimer
xref: UnificationXref11
xref: UnificationXref12
cellular location: plasma membrane
comment: Reactome DB_ID: 1222441

Bfr complex (iron-loaded)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry5
component stoichiometry: Stoichiometry6
component: iron (ferric)
component: Bfr dimer
xref: UnificationXref20
xref: UnificationXref21
cellular location: plasma membrane
comment: Reactome DB_ID: 1222552

Bfr dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry1
component stoichiometry: Stoichiometry2
component: heme
component: Bfr
xref: UnificationXref9
xref: UnificationXref10
cellular location: plasma membrane
comment: Reactome DB_ID: 1222734

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref67

Arg-tRNA(Arg)
type: SmallMoleculeReference
name: ChEBI:18366 Arg-tRNA(Arg)
xref: UnificationXref78

Val-tRNA(Val)
type: SmallMoleculeReference
name: ChEBI:29164 Val-tRNA(Val)
xref: UnificationXref132

Gln-tRNA(Gln) [ChEBI:29166]
type: SmallMoleculeReference
name: Gln-tRNA(Gln)
xref: UnificationXref90

ChEBI:16624 Leu-tRNA(Leu)
type: SmallMoleculeReference
name: Leu-tRNA(Leu)
xref: UnificationXref105

ChEBI:29159 Trp-tRNA(Trp)
type: SmallMoleculeReference
name: Trp-tRNA(Trp)
xref: UnificationXref126

UnificationXref142
type: UnificationXref
id: REACT_917
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_917.3

UnificationXref141
type: UnificationXref
id: 159884
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159884

http://identifiers.org/pubmed/4921478
type: PublicationXref
id: 4921478
author: Tompkins, RK
db: Pubmed
title: Sequential translation of trinucleotide codons for peptide bond formation, translocation, and termination
source: Proc Natl Acad Sci U S A 66:1164-9
year: 1970

Glu-tRNA(Glu)
type: SmallMoleculeReference
name: Glu-tRNA(Glu) [ChEBI:29157]
xref: UnificationXref93

UnificationXref140
type: UnificationXref
id: REACT_3051
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3051.1

ChEBI:29158 Asp-tRNA(Asp)
type: SmallMoleculeReference
name: Asp-tRNA(Asp)
xref: UnificationXref84

His-tRNA(His)
type: SmallMoleculeReference
name: ChEBI:29155 His-tRNA(His)
xref: UnificationXref99

Gly-tRNA(Gly) [ChEBI:29156]
type: SmallMoleculeReference
name: Gly-tRNA(Gly)
xref: UnificationXref96

ChEBI:29153 Phe-tRNA(Phe)
type: SmallMoleculeReference
name: Phe-tRNA(Phe)
xref: UnificationXref114

Pro-tRNA(Pro)
type: SmallMoleculeReference
name: ChEBI:29154 Pro-tRNA(Pro)
xref: UnificationXref117

Thr-tRNA(Thr)
type: SmallMoleculeReference
name: ChEBI:29163 Thr-tRNA(Thr)
xref: UnificationXref123

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref47

Ser-tRNA(Ser)
type: SmallMoleculeReference
name: ChEBI:29162 Ser-tRNA(Ser)
xref: UnificationXref120

Tyr-tRNA(Tyr)
type: SmallMoleculeReference
name: ChEBI:29161 Tyr-tRNA(Tyr)
xref: UnificationXref129

Ile-tRNA(Ile)
type: SmallMoleculeReference
name: ChEBI:29160 Ile-tRNA(Ile)
xref: UnificationXref102

Met-tRNA(Met) [ChEBI:16635]
type: SmallMoleculeReference
name: Met-tRNA(Met)
xref: UnificationXref111

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref61

ChEBI:17732 Ala-tRNA(Ala)
type: SmallMoleculeReference
name: Ala-tRNA(Ala)
xref: UnificationXref75

Fe(3+)
type: SmallMoleculeReference
name: ferric iron
name: Fe(III)
name: Fe3+
name: iron(3+)
name: FE (III) ION
name: Ferric ion
name: iron, ion (Fe(3+))
name: iron(3+) [ChEBI:29034]
xref: UnificationXref17

http://identifiers.org/pubmed/1703007
type: PublicationXref
id: 1703007
author: Picking, WD
author: Hardesty, B
author: Odom, OW
db: Pubmed
title: Movement of tRNA but not the nascent peptide during peptide bond formation on ribosomes
source: Biochemistry 29:10734-44
year: 1990

http://identifiers.org/pubmed/8726014
type: PublicationXref
id: 8726014
author: Frothingham, R
author: Meeker-O'Connell, WA
author: Talbot, EA
author: Kreuzer, KN
author: George, JW
db: Pubmed
title: Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA
source: Antimicrob Agents Chemother 40:1426-31
year: 1996

Enterochelin [ChEBI:4799]
type: SmallMoleculeReference
name: Enterobactin
name: tri-(2,3-dihydroxy-N-benzoyl-L-serine)-ester
name: tri-(N-(2,3-dihydroxybenzoyl)-L-serine)-ester
name: Enterochelin
xref: UnificationXref44

UnificationXref19
type: UnificationXref
id: REACT_201018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201018.1

UnificationXref110
type: UnificationXref
id: REACT_15620
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15620.1

UnificationXref17
type: UnificationXref
id: CHEBI:29034
db: ChEBI

UnificationXref111
type: UnificationXref
id: CHEBI:16635
db: ChEBI

UnificationXref18
type: UnificationXref
id: 1222433
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222433

UnificationXref112
type: UnificationXref
id: 379794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379794

UnificationXref15
type: UnificationXref
id: 71067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71067

UnificationXref113
type: UnificationXref
id: REACT_18004
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18004.1

UnificationXref16
type: UnificationXref
id: REACT_3428
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3428.2

UnificationXref13
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref14
type: UnificationXref
id: CHEBI:18248
db: ChEBI

UnificationXref11
type: UnificationXref
id: 1222441
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222441

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref1

UnificationXref12
type: UnificationXref
id: REACT_201177
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201177.1

UnificationXref10
type: UnificationXref
id: REACT_201250
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201250.1

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref50

UnificationXref115
type: UnificationXref
id: 379792
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379792

UnificationXref114
type: UnificationXref
id: CHEBI:29153
db: ChEBI

UnificationXref117
type: UnificationXref
id: CHEBI:29154
db: ChEBI

UnificationXref116
type: UnificationXref
id: REACT_15573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15573.1

UnificationXref119
type: UnificationXref
id: REACT_17288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17288.1

UnificationXref118
type: UnificationXref
id: 379746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379746

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref22

UnificationXref101
type: UnificationXref
id: REACT_17784
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17784.1

UnificationXref26
type: UnificationXref
id: 162613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162613

Catalysis2
type: Catalysis
data source: Reactome
controlled: Iron is reduced and separates from enterobactin
control type: ACTIVATION
xref: RelationshipXref3
xref: RelationshipXref4
controller: Fre

UnificationXref102
type: UnificationXref
id: CHEBI:29160
db: ChEBI

UnificationXref27
type: UnificationXref
id: REACT_3801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3801.1

Catalysis1
type: Catalysis
data source: Reactome
controlled: Ferritin takes up and mineralizes iron
control type: ACTIVATION
xref: RelationshipXref1
xref: RelationshipXref2
controller: Bfr

UnificationXref28
type: UnificationXref
id: 159881
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159881

UnificationXref100
type: UnificationXref
id: 379786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379786

UnificationXref29
type: UnificationXref
id: REACT_2485
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2485.1

Reactome
type: Provenance
comment: http://www.reactome.org

Catalysis3
type: Catalysis
data source: Reactome
controlled: E.Coli deamination of nicotinamide
control type: ACTIVATION
xref: RelationshipXref5
xref: RelationshipXref6
controller: PNCA_ECOLI

UnificationXref22
type: UnificationXref
id: MI:0355
db: MI

UnificationXref23
type: UnificationXref
id: 1222301
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222301

UnificationXref24
type: UnificationXref
id: REACT_200762
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_200762.1

UnificationXref25
type: UnificationXref
id: CHEBI:33699
db: ChEBI

Same Catalyst Activity
type: RelationshipTypeVocabulary

UnificationXref20
type: UnificationXref
id: 1222552
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222552

UnificationXref21
type: UnificationXref
id: REACT_201656
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201656.1

UnificationXref106
type: UnificationXref
id: 379757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379757

Nicotinamide
type: SmallMoleculeReference
name: Niacinamide
name: Vitamin PP
name: Nicotinamide [ChEBI:17154]
name: Nicotinic acid amide
xref: UnificationXref58

UnificationXref105
type: UnificationXref
id: CHEBI:16624
db: ChEBI

UnificationXref104
type: UnificationXref
id: REACT_17273
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17273.1

UnificationXref103
type: UnificationXref
id: 379787
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379787

UnificationXref109
type: UnificationXref
id: 379736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379736

UnificationXref108
type: UnificationXref
id: CHEBI:16047
db: ChEBI

UnificationXref107
type: UnificationXref
id: REACT_17915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17915.1

UnificationXref132
type: UnificationXref
id: CHEBI:29164
db: ChEBI

UnificationXref39
type: UnificationXref
id: 1222421
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222421

UnificationXref133
type: UnificationXref
id: 379790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379790

UnificationXref134
type: UnificationXref
id: REACT_15717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15717.1

UnificationXref37
type: UnificationXref
id: REACT_1434
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1434.3

UnificationXref135
type: UnificationXref
id: 37001
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=37001

UnificationXref38
type: UnificationXref
id: CHEBI:28199
db: ChEBI

UnificationXref130
type: UnificationXref
id: 379785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379785

UnificationXref131
type: UnificationXref
id: REACT_18116
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18116.1

UnificationXref31
type: UnificationXref
id: REACT_2291
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2291.1

UnificationXref32
type: UnificationXref
id: 159880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159880

UnificationXref30
type: UnificationXref
id: 141678
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141678

UnificationXref35
type: UnificationXref
id: REACT_4510
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4510.1

UnificationXref36
type: UnificationXref
id: 159887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159887

JW1757
type: ProteinReference
name: nam
name: b1768
name: pncA
name: UniProt:P21369 pncA
name: ydjB
xref: UnificationXref70
comment: CATALYTIC ACTIVITY Nicotinamide + H(2)O = nicotinate + NH(3).PATHWAY Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.SIMILARITY Belongs to the PncA family.
organism: Escherichia coli

UnificationXref33
type: UnificationXref
id: REACT_4204
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4204.1

UnificationXref34
type: UnificationXref
id: 159891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159891

UnificationXref137
type: UnificationXref
id: 72393
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72393

UnificationXref136
type: UnificationXref
id: REACT_4792
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4792.1

UnificationXref139
type: UnificationXref
id: 159889
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159889

UnificationXref138
type: UnificationXref
id: REACT_4829
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4829.1

UnificationXref123
type: UnificationXref
id: CHEBI:29163
db: ChEBI

UnificationXref48
type: UnificationXref
id: 70106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 213

UnificationXref124
type: UnificationXref
id: 379783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379783

UnificationXref49
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

UnificationXref121
type: UnificationXref
id: 379738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379738

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 233

UnificationXref122
type: UnificationXref
id: REACT_17419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17419.1

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 1

Nicotinate [ChEBI:7559]
type: SmallMoleculeReference
name: 3-Pyridinecarboxylic acid
name: Nicotinate
name: Nicotinic acid
name: Niacin
xref: UnificationXref64

UnificationXref120
type: UnificationXref
id: CHEBI:29162
db: ChEBI

http://identifiers.org/pubmed/7027051
type: PublicationXref
id: 7027051
author: Holschuh, K
author: Riesner, D
author: Gassen, HG
db: Pubmed
title: Steps of mRNA translocation in protein biosynthesis
source: Nature 293:675-7
year: 1981

UnificationXref40
type: UnificationXref
id: REACT_201740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201740.1

UnificationXref41
type: UnificationXref
id: CHEBI:16474
db: ChEBI

UnificationXref42
type: UnificationXref
id: 29364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

UnificationXref43
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

UnificationXref44
type: UnificationXref
id: CHEBI:28855
db: ChEBI

UnificationXref45
type: UnificationXref
id: 1222366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222366

UnificationXref46
type: UnificationXref
id: REACT_200966
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_200966.1

UnificationXref47
type: UnificationXref
id: CHEBI:15378
db: ChEBI

NADPH
type: SmallMolecule
entity reference: NADPH
data source: Reactome
xref: UnificationXref42
xref: UnificationXref43
cellular location: cytosol
comment: Reactome DB_ID: 29364
display name: TPNH

Enterobactin:Fe3+
type: SmallMolecule
entity reference: Fe-enterobactin [ChEBI:4993]
data source: Reactome
xref: UnificationXref39
xref: UnificationXref40
cellular location: cytosol
comment: Reactome DB_ID: 1222421

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref48
xref: UnificationXref49
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

Enterobactin
type: SmallMolecule
entity reference: Enterochelin [ChEBI:4799]
data source: Reactome
xref: UnificationXref45
xref: UnificationXref46
cellular location: cytosol
comment: Reactome DB_ID: 1222366

Fe(III)
type: SmallMolecule
entity reference: iron (ferrous)
data source: Reactome
name: iron (ferrous)
name: Fe3+
name: Fe(II)
name: Iron
name: Fe++
xref: UnificationXref15
xref: UnificationXref16
cellular location: cytosol
comment: Reactome DB_ID: 71067
display name: Fe2+

heme
type: SmallMolecule
entity reference: Protoheme
data source: Reactome
xref: UnificationXref4
xref: UnificationXref3
cellular location: plasma membrane
comment: Reactome DB_ID: 917919

messenger RNA
type: SmallMolecule
entity reference: messenger RNA [ChEBI:33699]
data source: Reactome
xref: UnificationXref26
xref: UnificationXref27
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 162613
display name: mRNA

UnificationXref50
type: UnificationXref
id: CHEBI:18009
db: ChEBI

iron (ferric)
type: SmallMolecule
entity reference: Fe(3+)
data source: Reactome
xref: UnificationXref19
xref: UnificationXref18
cellular location: plasma membrane
comment: Reactome DB_ID: 1222433
display name: Fe3+

UnificationXref129
type: UnificationXref
id: CHEBI:29161
db: ChEBI

UnificationXref128
type: UnificationXref
id: REACT_17447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17447.1

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref127
type: UnificationXref
id: 379765
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379765

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 158

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Reactome
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref52
xref: UnificationXref51
cellular location: cytosol
comment: Reactome DB_ID: 29366
display name: TPN

UnificationXref126
type: UnificationXref
id: CHEBI:29159
db: ChEBI

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref125
type: UnificationXref
id: REACT_17415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17415.1