Cross-presentation of soluble exogenous antigens (endosomes)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1455
evidence: Evidence2313
xref: RelationshipXref1780
xref: UnificationXref14694
xref: UnificationXref14693
pathway order: PathwayStep2273
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4687
type: SequenceSite
position status: EQUAL
sequence position: 216

SequenceSite4688
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4685
type: SequenceSite
position status: EQUAL
sequence position: 1204

SequenceSite4686
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4683
type: SequenceSite
position status: EQUAL
sequence position: 1129

SequenceSite4684
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4681
type: SequenceSite
position status: EQUAL
sequence position: 1127

SequenceSite4682
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2749
type: Stoichiometry
physical entity: PhysicalEntity187
stoichiometric coefficient: 1.0

SequenceSite4680
type: SequenceSite
position status: EQUAL
sequence position: 1084

Stoichiometry2748
type: Stoichiometry
physical entity: Protein2425
stoichiometric coefficient: 1.0

Stoichiometry2747
type: Stoichiometry
physical entity: Protein2434
stoichiometric coefficient: 1.0

Stoichiometry2741
type: Stoichiometry
physical entity: Protein2449
stoichiometric coefficient: 1.0

Stoichiometry2742
type: Stoichiometry
physical entity: Protein2437
stoichiometric coefficient: 1.0

Stoichiometry2740
type: Stoichiometry
physical entity: Protein2435
stoichiometric coefficient: 1.0

Stoichiometry2745
type: Stoichiometry
physical entity: Protein2446
stoichiometric coefficient: 1.0

Stoichiometry2746
type: Stoichiometry
physical entity: Complex990
stoichiometric coefficient: 1.0

Stoichiometry2743
type: Stoichiometry
physical entity: Protein2452
stoichiometric coefficient: 1.0

Stoichiometry2744
type: Stoichiometry
physical entity: Complex1005
stoichiometric coefficient: 1.0

mRNA decay by 3' to 5' exoribonuclease
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1267
evidence: Evidence1922
xref: UnificationXref12436
xref: UnificationXref12435
xref: RelationshipXref1597
pathway order: PathwayStep1885
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4679
type: SequenceSite
position status: EQUAL
sequence position: 1107

SequenceSite4678
type: SequenceSite
position status: EQUAL
sequence position: 1089

SequenceSite4674
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4675
type: SequenceSite
position status: EQUAL
sequence position: 790

SequenceSite4676
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4677
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite4670
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4671
type: SequenceSite
position status: EQUAL
sequence position: 411

SequenceSite4672
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4673
type: SequenceSite
position status: EQUAL
sequence position: 1272

Stoichiometry2737
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 10.0

http://identifiers.org/pubmed/11903050
type: PublicationXref
id: 11903050
author: MacMullen, CM
author: Smith, TJ
author: Poncz, M
author: Hsu, BY
author: Fang, J
author: Stanley, CA
db: Pubmed
title: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
source: Biochem J 363:81-7
year: 2002

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

Stoichiometry2736
type: Stoichiometry
physical entity: Protein2444
stoichiometric coefficient: 1.0

Stoichiometry2739
type: Stoichiometry
physical entity: Protein2447
stoichiometric coefficient: 1.0

Stoichiometry2738
type: Stoichiometry
physical entity: Protein2440
stoichiometric coefficient: 1.0

Stoichiometry2730
type: Stoichiometry
physical entity: Protein2424
stoichiometric coefficient: 1.0

Stoichiometry2731
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

Stoichiometry2732
type: Stoichiometry
physical entity: Protein2433
stoichiometric coefficient: 1.0

Stoichiometry2733
type: Stoichiometry
physical entity: Complex999
stoichiometric coefficient: 1.0

Stoichiometry2734
type: Stoichiometry
physical entity: Protein2438
stoichiometric coefficient: 1.0

Stoichiometry2735
type: Stoichiometry
physical entity: Protein2443
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/8774846
type: PublicationXref
id: 8774846
author: Cohen, P
author: Young, P R
author: Clifton, A D
db: Pubmed
title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
source: FEBS Lett. 392:209-14
year: 1996

http://identifiers.org/pubmed/8662638
type: PublicationXref
id: 8662638
author: Wilson, MP
author: Majerus, PW
db: Pubmed
title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
source: J Biol Chem 271:11904-10
year: 1996

SequenceSite4668
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4667
type: SequenceSite
position status: EQUAL
sequence position: 146

SequenceSite4669
type: SequenceSite
position status: EQUAL
sequence position: 174

Stoichiometry2769
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 2.0

Stoichiometry2767
type: Stoichiometry
physical entity: Complex1008
stoichiometric coefficient: 1.0

Stoichiometry2768
type: Stoichiometry
physical entity: Protein2431
stoichiometric coefficient: 1.0

Stoichiometry2765
type: Stoichiometry
physical entity: PhysicalEntity188
stoichiometric coefficient: 1.0

Stoichiometry2766
type: Stoichiometry
physical entity: Complex871
stoichiometric coefficient: 1.0

Stoichiometry2763
type: Stoichiometry
physical entity: Complex992
stoichiometric coefficient: 1.0

Stoichiometry2764
type: Stoichiometry
physical entity: Protein2432
stoichiometric coefficient: 1.0

Stoichiometry2761
type: Stoichiometry
physical entity: Protein2467
stoichiometric coefficient: 1.0

Stoichiometry2762
type: Stoichiometry
physical entity: Protein2468
stoichiometric coefficient: 1.0

Stoichiometry2760
type: Stoichiometry
physical entity: SMC1 (BAA11495)
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

SequenceSite4692
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4693
type: SequenceSite
position status: EQUAL
sequence position: 338

SequenceSite4694
type: SequenceSite
position status: EQUAL
sequence position: 92

SequenceSite4695
type: SequenceSite
position status: EQUAL
sequence position: 203

SequenceSite4696
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4697
type: SequenceSite
position status: EQUAL
sequence position: 338

SequenceSite4698
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4699
type: SequenceSite
position status: EQUAL
sequence position: 326

UnificationXref2506
type: UnificationXref
id: 5579107
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579107

UnificationXref2507
type: UnificationXref
id: 5579108
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579108

UnificationXref2508
type: UnificationXref
id: 5579110
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579110

UnificationXref2509
type: UnificationXref
id: REACT_98912
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98912.4

UnificationXref2502
type: UnificationXref
id: DDB0185087
db: UniProt

Stoichiometry2759
type: Stoichiometry
physical entity: Protein2442
stoichiometric coefficient: 1.0

UnificationXref2503
type: UnificationXref
id: 5579104
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579104

Stoichiometry2758
type: Stoichiometry
physical entity: Protein2441
stoichiometric coefficient: 1.0

UnificationXref2504
type: UnificationXref
id: 5579105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579105

SequenceSite4690
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2505
type: UnificationXref
id: 5579106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579106

SequenceSite4691
type: SequenceSite
position status: EQUAL
sequence position: 216

Stoichiometry2754
type: Stoichiometry
physical entity: Protein2455
stoichiometric coefficient: 1.0

Stoichiometry2755
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 16.0

UnificationXref2501
type: UnificationXref
id: REACT_3116
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3116.2

Stoichiometry2756
type: Stoichiometry
physical entity: Protein2439
stoichiometric coefficient: 1.0

UnificationXref2500
type: UnificationXref
id: 29800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29800

Stoichiometry2757
type: Stoichiometry
physical entity: Complex988
stoichiometric coefficient: 1.0

Stoichiometry2750
type: Stoichiometry
physical entity: Protein2448
stoichiometric coefficient: 1.0

Stoichiometry2751
type: Stoichiometry
physical entity: Complex995
stoichiometric coefficient: 1.0

Stoichiometry2752
type: Stoichiometry
physical entity: Complex997
stoichiometric coefficient: 1.0

Stoichiometry2753
type: Stoichiometry
physical entity: Protein2436
stoichiometric coefficient: 1.0

SequenceSite4689
type: SequenceSite
position status: EQUAL
sequence position: 1204

http://identifiers.org/pubmed/17322878
type: PublicationXref
id: 17322878
author: Citri, A
author: Yarden, Y
author: Amit, I
author: Jacob-Hirsch, J
author: Siwak, D
author: Segal, E
author: Lu, Y
author: Tarcic, G
author: Amariglio, N
author: Mills, GB
author: Katz, M
author: Shay, T
author: Vaisman, N
author: Lahad, J
author: Domany, E
author: Rechavi, G
author: Alon, U
author: Zhang, F
db: Pubmed
title: A module of negative feedback regulators defines growth factor signaling
source: Nat Genet 39:503-12
year: 2007

UnificationXref2516
type: UnificationXref
id: 5579847
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579847

UnificationXref2515
type: UnificationXref
id: 5579161
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579161

UnificationXref2514
type: UnificationXref
id: 5579160
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579160

UnificationXref2513
type: UnificationXref
id: DDB0191349
db: UniProt

UnificationXref2519
type: UnificationXref
id: 30485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30485

UnificationXref2518
type: UnificationXref
id: CHEBI:17835
db: ChEBI

UnificationXref2517
type: UnificationXref
id: REACT_196084
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_196084.3

Stoichiometry2782
type: Stoichiometry
physical entity: Complex988
stoichiometric coefficient: 1.0

Stoichiometry2781
type: Stoichiometry
physical entity: Protein2439
stoichiometric coefficient: 1.0

Stoichiometry2780
type: Stoichiometry
physical entity: Protein2438
stoichiometric coefficient: 1.0

Stoichiometry2786
type: Stoichiometry
physical entity: SMC1 (BAA11495)
stoichiometric coefficient: 1.0

Stoichiometry2785
type: Stoichiometry
physical entity: Protein2442
stoichiometric coefficient: 1.0

Stoichiometry2784
type: Stoichiometry
physical entity: Protein2441
stoichiometric coefficient: 1.0

Stoichiometry2783
type: Stoichiometry
physical entity: Protein2440
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

UnificationXref2511
type: UnificationXref
id: 29728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29728

UnificationXref2512
type: UnificationXref
id: REACT_3406
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3406.2

Stoichiometry2789
type: Stoichiometry
physical entity: Protein2424
stoichiometric coefficient: 1.0

Stoichiometry2788
type: Stoichiometry
physical entity: Protein2444
stoichiometric coefficient: 1.0

UnificationXref2510
type: UnificationXref
id: CHEBI:17794
db: ChEBI

Stoichiometry2787
type: Stoichiometry
physical entity: Protein2443
stoichiometric coefficient: 1.0

UnificationXref2525
type: UnificationXref
id: 5579760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579760

UnificationXref2524
type: UnificationXref
id: 5579759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579759

UnificationXref2527
type: UnificationXref
id: 5579794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579794

UnificationXref2526
type: UnificationXref
id: 5579761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579761

UnificationXref2529
type: UnificationXref
id: CHEBI:18021
db: ChEBI

UnificationXref2528
type: UnificationXref
id: REACT_196068
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_196068.3

Stoichiometry2771
type: Stoichiometry
physical entity: Protein2436
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

Stoichiometry2770
type: Stoichiometry
physical entity: Protein2448
stoichiometric coefficient: 1.0

Stoichiometry2773
type: Stoichiometry
physical entity: Complex895
stoichiometric coefficient: 1.0

Stoichiometry2772
type: Stoichiometry
physical entity: Complex1009
stoichiometric coefficient: 1.0

Stoichiometry2775
type: Stoichiometry
physical entity: Complex999
stoichiometric coefficient: 1.0

Stoichiometry2774
type: Stoichiometry
physical entity: Protein2433
stoichiometric coefficient: 1.0

UnificationXref2520
type: UnificationXref
id: REACT_3473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3473.2

Stoichiometry2777
type: Stoichiometry
physical entity: Protein2434
stoichiometric coefficient: 1.0

UnificationXref2521
type: UnificationXref
id: DDB0231354
db: UniProt

Stoichiometry2776
type: Stoichiometry
physical entity: Complex990
stoichiometric coefficient: 1.0

UnificationXref2522
type: UnificationXref
id: 5579757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579757

Stoichiometry2779
type: Stoichiometry
physical entity: Protein2437
stoichiometric coefficient: 1.0

UnificationXref2523
type: UnificationXref
id: 5579758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579758

Stoichiometry2778
type: Stoichiometry
physical entity: Protein2435
stoichiometric coefficient: 1.0

UnificationXref2539
type: UnificationXref
id: REACT_225797
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_225797.2

UnificationXref2538
type: UnificationXref
id: 5579795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579795

UnificationXref2537
type: UnificationXref
id: 5579171
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579171

UnificationXref2536
type: UnificationXref
id: 5579170
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579170

UnificationXref2535
type: UnificationXref
id: 5579169
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579169

http://identifiers.org/pubmed/7356336
type: PublicationXref
id: 7356336
author: Logue, EA
author: Fall, RR
author: Hector, ML
author: Cochran, BC
db: Pubmed
title: Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
source: Arch Biochem Biophys 199:28-36
year: 1980

Keratan sulfate degradation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction127
pathway component: BiochemicalReaction126
evidence: Evidence243
xref: RelationshipXref148
xref: UnificationXref2019
xref: UnificationXref2020
pathway order: PathwayStep225
pathway order: PathwayStep224
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2533
type: UnificationXref
id: 5579167
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579167

UnificationXref2534
type: UnificationXref
id: 5579168
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579168

UnificationXref2531
type: UnificationXref
id: REACT_5622
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5622.2

UnificationXref2532
type: UnificationXref
id: DDB0231355
db: UniProt

UnificationXref2530
type: UnificationXref
id: 29492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29492

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

UnificationXref2547
type: UnificationXref
id: 5579807
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579807

UnificationXref2546
type: UnificationXref
id: 5579806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579806

UnificationXref2549
type: UnificationXref
id: 5579809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579809

UnificationXref2548
type: UnificationXref
id: 5579808
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579808

http://identifiers.org/pubmed/8631325
type: PublicationXref
id: 8631325
author: Peng, HL
author: Chao, YC
author: Chang, HY
author: Duggleby, RG
author: Huang, JG
db: Pubmed
title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
source: Eur J Biochem 235:173-9
year: 1996

Stoichiometry2791
type: Stoichiometry
physical entity: Protein2446
stoichiometric coefficient: 1.0

Stoichiometry2790
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

Stoichiometry2793
type: Stoichiometry
physical entity: Protein2425
stoichiometric coefficient: 1.0

Stoichiometry2792
type: Stoichiometry
physical entity: Protein2447
stoichiometric coefficient: 1.0

UnificationXref2542
type: UnificationXref
id: 5579802
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579802

Stoichiometry2799
type: Stoichiometry
physical entity: Complex1006
stoichiometric coefficient: 1.0

UnificationXref2543
type: UnificationXref
id: 5579803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579803

Stoichiometry2798
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 20.0

UnificationXref2544
type: UnificationXref
id: 5579805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579805

UnificationXref2545
type: UnificationXref
id: REACT_85253
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85253.4

Stoichiometry2795
type: Stoichiometry
physical entity: Protein2449
stoichiometric coefficient: 1.0

Stoichiometry2794
type: Stoichiometry
physical entity: Complex995
stoichiometric coefficient: 1.0

UnificationXref2540
type: UnificationXref
id: 5579799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579799

Stoichiometry2797
type: Stoichiometry
physical entity: Protein2452
stoichiometric coefficient: 1.0

UnificationXref2541
type: UnificationXref
id: 5579800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579800

Stoichiometry2796
type: Stoichiometry
physical entity: Protein2455
stoichiometric coefficient: 1.0

UnificationXref2550
type: UnificationXref
id: 5592308
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592308

UnificationXref2552
type: UnificationXref
id: CHEBI:30797
db: ChEBI

UnificationXref2551
type: UnificationXref
id: REACT_259921
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259921.1

UnificationXref2554
type: UnificationXref
id: REACT_4778
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4778.2

UnificationXref2553
type: UnificationXref
id: 113544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113544

UnificationXref2556
type: UnificationXref
id: REACT_5781
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5781.2

UnificationXref2555
type: UnificationXref
id: 113548
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113548

SequenceSite4600
type: SequenceSite
position status: EQUAL
sequence position: 49

UnificationXref2557
type: UnificationXref
id: 198498
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198498

UnificationXref2558
type: UnificationXref
id: REACT_11975
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11975.2

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

UnificationXref2559
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

UnificationXref2563
type: UnificationXref
id: REACT_214785
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_214785.2

UnificationXref2562
type: UnificationXref
id: 5585759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585759

UnificationXref2561
type: UnificationXref
id: 5585757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585757

UnificationXref2560
type: UnificationXref
id: DDB0234071
db: UniProt

UnificationXref2567
type: UnificationXref
id: 5584732
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584732

UnificationXref2566
type: UnificationXref
id: 5584730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584730

UnificationXref2565
type: UnificationXref
id: 5584729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584729

UnificationXref2564
type: UnificationXref
id: DDB0230188
db: UniProt

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

UnificationXref2568
type: UnificationXref
id: REACT_256851
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256851.1

UnificationXref2569
type: UnificationXref
id: 113587
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113587

UnificationXref2576
type: UnificationXref
id: 113553
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113553

UnificationXref2575
type: UnificationXref
id: REACT_3871
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3871.2

UnificationXref2578
type: UnificationXref
id: DDB0230092
db: UniProt

Post-translational modification: synthesis of GPI-anchored proteins
type: Pathway
data source: Provenance1
pathway component: REACT 203577.2
pathway component: REACT 223860.2
evidence: Evidence2029
xref: RelationshipXref1650
xref: UnificationXref13106
xref: UnificationXref13105
pathway order: PathwayStep1982
pathway order: PathwayStep1991
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2577
type: UnificationXref
id: REACT_5003
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5003.2

UnificationXref2572
type: UnificationXref
id: 113552
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113552

UnificationXref2571
type: UnificationXref
id: CHEBI:16015
db: ChEBI

UnificationXref2574
type: UnificationXref
id: 113594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113594

UnificationXref2573
type: UnificationXref
id: REACT_4423
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4423.2

SequenceSite4613
type: SequenceSite
position status: EQUAL
sequence position: 477

SequenceSite4612
type: SequenceSite
position status: EQUAL
sequence position: 17

UnificationXref2570
type: UnificationXref
id: REACT_5253
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5253.2

SequenceSite4615
type: SequenceSite
position status: EQUAL
sequence position: 1063

SequenceSite4614
type: SequenceSite
position status: EQUAL
sequence position: 27

SequenceSite4617
type: SequenceSite
position status: EQUAL
sequence position: 195

SequenceSite4616
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4619
type: SequenceSite
position status: EQUAL
sequence position: 958

SequenceSite4618
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4620
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4621
type: SequenceSite
position status: EQUAL
sequence position: 293

SequenceSite4622
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2579
type: UnificationXref
id: 5579218
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579218

UnificationXref2589
type: UnificationXref
id: 5585743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585743

UnificationXref2588
type: UnificationXref
id: 5585741
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585741

UnificationXref2587
type: UnificationXref
id: 5585740
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585740

UnificationXref2586
type: UnificationXref
id: 5585739
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585739

SequenceSite4609
type: SequenceSite
position status: EQUAL
sequence position: 518

UnificationXref2585
type: UnificationXref
id: DDB0234089
db: UniProt

UnificationXref2584
type: UnificationXref
id: REACT_4309
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4309.3

UnificationXref2583
type: UnificationXref
id: 29404
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29404

UnificationXref2582
type: UnificationXref
id: REACT_247068
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247068.1

UnificationXref2581
type: UnificationXref
id: 5579242
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579242

SequenceSite4604
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref2580
type: UnificationXref
id: 5579219
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579219

SequenceSite4603
type: SequenceSite
position status: EQUAL
sequence position: 597

SequenceSite4602
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4601
type: SequenceSite
position status: EQUAL
sequence position: 1012

SequenceSite4608
type: SequenceSite
position status: EQUAL
sequence position: 35

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

SequenceSite4607
type: SequenceSite
position status: EQUAL
sequence position: 475

SequenceSite4606
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite4605
type: SequenceSite
position status: EQUAL
sequence position: 593

SequenceSite4610
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4611
type: SequenceSite
position status: EQUAL
sequence position: 360

Choline
type: SmallMoleculeReference
name: Choline [ChEBI:3665]
name: Bilineurine
xref: UnificationXref14960

SequenceSite4638
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4639
type: SequenceSite
position status: EQUAL
sequence position: 91

http://identifiers.org/pubmed/12700044
type: PublicationXref
id: 12700044
author: Maness, PF
author: Thelen, K
author: Panicker, AK
author: Buhusi, M
db: Pubmed
title: Cellular signalling mechanisms of neural cell adhesion molecules
source: Front Biosci 8:d900-11
year: 2003

SequenceSite4634
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2590
type: UnificationXref
id: REACT_205879
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205879.2

SequenceSite4635
type: SequenceSite
position status: EQUAL
sequence position: 275

UnificationXref2591
type: UnificationXref
id: DDB0230093
db: UniProt

SequenceSite4636
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2592
type: UnificationXref
id: 5579194
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579194

SequenceSite4637
type: SequenceSite
position status: EQUAL
sequence position: 133

UnificationXref2593
type: UnificationXref
id: CHEBI:18405
db: ChEBI

UnificationXref2594
type: UnificationXref
id: 29390
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29390

UnificationXref2595
type: UnificationXref
id: REACT_3649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3649.2

UnificationXref2596
type: UnificationXref
id: 5579195
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579195

UnificationXref2597
type: UnificationXref
id: 5579213
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579213

UnificationXref2598
type: UnificationXref
id: REACT_233513
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233513.1

UnificationXref2599
type: UnificationXref
id: CHEBI:16526
db: ChEBI

SequenceSite4642
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4641
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite4644
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4643
type: SequenceSite
position status: EQUAL
sequence position: 95

SequenceSite4640
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4629
type: SequenceSite
position status: EQUAL
sequence position: 245

SequenceSite4627
type: SequenceSite
position status: EQUAL
sequence position: 235

SequenceSite4628
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4625
type: SequenceSite
position status: EQUAL
sequence position: 272

SequenceSite4626
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4623
type: SequenceSite
position status: EQUAL
sequence position: 276

SequenceSite4624
type: SequenceSite
position status: EQUAL
sequence position: 1

XBP1(S) activates chaperone genes
type: Pathway
data source: Provenance1
pathway component: TemplateReaction43
pathway component: TemplateReaction42
pathway component: TemplateReaction41
pathway component: TemplateReaction40
pathway component: TemplateReaction29
pathway component: TemplateReaction47
pathway component: TemplateReaction28
pathway component: TemplateReaction46
pathway component: TemplateReaction27
pathway component: TemplateReaction45
pathway component: TemplateReaction26
pathway component: TemplateReaction44
pathway component: TemplateReaction25
pathway component: TemplateReaction49
pathway component: TemplateReaction48
pathway component: TemplateReaction30
pathway component: TemplateReaction50
pathway component: TemplateReaction32
pathway component: TemplateReaction31
pathway component: TemplateReaction52
pathway component: TemplateReaction51
pathway component: TemplateReaction54
pathway component: TemplateReaction53
pathway component: TemplateReaction38
pathway component: TemplateReaction37
pathway component: TemplateReaction39
pathway component: TemplateReaction34
pathway component: TemplateReaction33
pathway component: TemplateReaction36
pathway component: TemplateReaction35
evidence: Evidence2134
xref: UnificationXref13744
xref: UnificationXref13745
pathway order: PathwayStep2078
pathway order: PathwayStep2079
pathway order: PathwayStep2082
pathway order: PathwayStep2081
pathway order: PathwayStep2084
pathway order: PathwayStep2083
pathway order: PathwayStep2086
pathway order: PathwayStep2085
pathway order: PathwayStep2088
pathway order: PathwayStep2087
pathway order: PathwayStep2080
pathway order: PathwayStep2074
pathway order: PathwayStep2075
pathway order: PathwayStep2076
pathway order: PathwayStep2089
pathway order: PathwayStep2077
pathway order: PathwayStep2070
pathway order: PathwayStep2071
pathway order: PathwayStep2072
pathway order: PathwayStep2073
pathway order: PathwayStep2095
pathway order: PathwayStep2094
pathway order: PathwayStep2093
pathway order: PathwayStep2092
pathway order: PathwayStep2068
pathway order: PathwayStep2067
pathway order: PathwayStep2069
pathway order: PathwayStep2096
pathway order: PathwayStep2091
pathway order: PathwayStep2090
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/15538381
type: PublicationXref
id: 15538381
author: Lu, M
author: Gherzi, R
author: Leuenberger, SA
author: Hemmings, BA
author: Stoecklin, G
author: Hess, D
author: Mallaun, M
author: Schmidlin, M
author: Moroni, C
author: Gross, B
db: Pubmed
title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
source: EMBO J 23:4760-9
year: 2004

SequenceSite4633
type: SequenceSite
position status: EQUAL
sequence position: 291

SequenceSite4632
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4631
type: SequenceSite
position status: EQUAL
sequence position: 439

SequenceSite4630
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4656
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4657
type: SequenceSite
position status: EQUAL
sequence position: 991

SequenceSite4658
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4659
type: SequenceSite
position status: EQUAL
sequence position: 520

SequenceSite4660
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4662
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4661
type: SequenceSite
position status: EQUAL
sequence position: 628

SequenceSite4664
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4663
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite4666
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

SequenceSite4665
type: SequenceSite
position status: EQUAL
sequence position: 305

SequenceSite4647
type: SequenceSite
position status: EQUAL
sequence position: 139

SequenceSite4648
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

SequenceSite4645
type: SequenceSite
position status: EQUAL
sequence position: 102

SequenceSite4646
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4649
type: SequenceSite
position status: EQUAL
sequence position: 80

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

SequenceSite4651
type: SequenceSite
position status: EQUAL
sequence position: 1706

SequenceSite4650
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4655
type: SequenceSite
position status: EQUAL
sequence position: 3661

SequenceSite4654
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4653
type: SequenceSite
position status: EQUAL
sequence position: 1129

SequenceSite4652
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 961

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 961

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 726

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 730

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0304416
data source: Provenance1
name: DDB0304416
name: middle-chain acyl-CoA synthetase 1
xref: UnificationXref8306
feature: FragmentFeature1358
cellular location: GO_0005759
comment: Reactome DB_ID: 5582889
display name: ACSM1

ACSM2B-like proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8328
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5582893

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266648
data source: Provenance1
name: DDB0266648
name: ACY1_HUMAN
name: Aminoacylase-1
xref: UnificationXref8356
feature: FragmentFeature1359
cellular location: GO_0005829
comment: Reactome DB_ID: 5592251
display name: ACY1

Mitoferrin1,2
type: Protein
data source: Provenance1
member physical entity: DDB0237598
xref: UnificationXref8369
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589119

UniProt:DDB0231296
type: ProteinReference
xref: UnificationXref12334
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187641
data source: Provenance1
name: Glutathione S-transferase theta-2B ecNumber2.5.1.18/ecNumber
name: DDB0187641
name: GSTT2_HUMAN
xref: UnificationXref8289
feature: FragmentFeature1356
cellular location: GO_0005829
comment: Reactome DB_ID: 5583643
display name: GSTT2B

UniProt:DDB0231297
type: ProteinReference
xref: UnificationXref12037
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191799
data source: Provenance1
name: Glutathione S-transferase theta-2B ecNumber2.5.1.18/ecNumber
name: DDB0191799
name: GSTT2_HUMAN
xref: UnificationXref8288
feature: FragmentFeature1355
cellular location: GO_0005829
comment: Reactome DB_ID: 5583642
display name: GSTT2B

UniProt:DDB0231298
type: ProteinReference
xref: UnificationXref12047
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0304416
data source: Provenance1
name: DDB0304416
name: Xenobiotic/medium-chain fatty acid:CoA ligase
xref: UnificationXref8305
feature: FragmentFeature1357
cellular location: GO_0005759
comment: Reactome DB_ID: 5582888
display name: ACSM2B

xenobiotic/medium-chain fatty acid:CoA ligases
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8307
cellular location: GO_0005759
comment: Reactome DB_ID: 5582890
comment: Converted from EntitySet in Reactome

UniProt:DDB0231294
type: ProteinReference
xref: UnificationXref6331
organism: http://identifiers.org/taxonomy/44689

Homologues of GSTT2B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8290
cellular location: GO_0005829
comment: Reactome DB_ID: 5583644
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187641
data source: Provenance1
name: GSTT1_HUMAN
name: Glutathione S-transferase theta-1 ecNumber2.5.1.18/ecNumber
name: DDB0187641
xref: UnificationXref8285
feature: FragmentFeature1354
cellular location: GO_0005829
comment: Reactome DB_ID: 5583639
display name: GSTT1

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 117

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 112

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 125

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 1087

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 301

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191799
data source: Provenance1
name: GSTT1_HUMAN
name: Glutathione S-transferase theta-1 ecNumber2.5.1.18/ecNumber
name: DDB0191799
xref: UnificationXref8283
feature: FragmentFeature1353
cellular location: GO_0005829
comment: Reactome DB_ID: 5583635
display name: GSTT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231404
data source: Provenance1
name: Glutathione synthase
name: DDB0231404
xref: UnificationXref8255
feature: FragmentFeature1352
cellular location: GO_0005829
comment: Reactome DB_ID: 5583599
display name: GSS

Homologues of GSTT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8286
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583640

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266708
data source: Provenance1
name: bisphosphate 3'-nucleotidase 1
name: DDB0266708
xref: UnificationXref8236
feature: FragmentFeature1350
cellular location: GO_0005829
comment: Reactome DB_ID: 5583681
display name: BPNT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304678
data source: Provenance1
name: 5-oxoprolinase
name: DDB0304678
name: OPLA_HUMAN
xref: UnificationXref8247
feature: FragmentFeature1351
cellular location: GO_0005829
comment: Reactome DB_ID: 5588992
display name: OPLAH

UniProt:DDB0231287
type: ProteinReference
xref: UnificationXref2734
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0202972
data source: Provenance1
name: DDB0202972
name: UDP-glucuronate transporter
xref: UnificationXref8228
feature: FragmentFeature1349
cellular location: GO_0005789
comment: Reactome DB_ID: 5583549
display name: SLC35D1

UniProt:DDB0231288
type: ProteinReference
xref: UnificationXref6329
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231684
data source: Provenance1
name: DDB0231684
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: acyl-CoA synthetase short-chain family member 1
xref: UnificationXref8214
feature: FragmentFeature1348
cellular location: GO_0005759
comment: Reactome DB_ID: 5587647
display name: ACSS1

UniProt:DDB0231285
type: ProteinReference
xref: UnificationXref2723
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231711
data source: Provenance1
name: MAO-A
name: DDB0231711
xref: UnificationXref8192
feature: FragmentFeature1347
cellular location: GO_0005741
comment: Reactome DB_ID: 5582650
display name: MAOA

UniProt:DDB0266928
type: ProteinReference
xref: UnificationXref2182
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266407
data source: Provenance1
name: DDB0266407
name: MAO-B
xref: UnificationXref8181
feature: FragmentFeature1346
cellular location: GO_0005741
comment: Reactome DB_ID: 5582658
display name: MAOB

UniProt:DDB0231283
type: ProteinReference
xref: UnificationXref2775
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188650
data source: Provenance1
name: DDB0188650
name: FMO form 2
name: Hepatic flavin-containing monooxygenase 3
name: FMO II
name: Dimethylaniline monooxygenase (N-oxide forming) 3
name: Dimethylaniline oxidase 3
xref: UnificationXref8166
feature: FragmentFeature1345
cellular location: GO_0005789
comment: Reactome DB_ID: 5582643
display name: FMO3

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9712840
type: PublicationXref
id: 9712840
author: Kikuchi, Y
author: Mizutani, M
author: Katada, T
author: Imai, M
author: Hoshino, S
author: Hanaoka, F
author: Ui, M
db: Pubmed
title: Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.
source: J Biol Chem 273:22254-9
year: 1998

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 142

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 67

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 5

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 1970

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 150

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231413
data source: Provenance1
name: Ferrochelatase
name: DDB0231413
name: HEMZ_HUMAN
xref: UnificationXref8086
feature: FragmentFeature1339
cellular location: GO_0005759
comment: Reactome DB_ID: 5583840
display name: FECH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231473
data source: Provenance1
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
name: DDB0231473
xref: UnificationXref8101
feature: FragmentFeature1340
cellular location: GO_0005743
comment: Reactome DB_ID: 5591613
display name: COX10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214997
data source: Provenance1
name: COX15_HUMAN
name: DDB0214997
name: Cytochrome c oxidase assembly protein COX15 homolog
xref: UnificationXref8108
feature: FragmentFeature1341
cellular location: GO_0005743
comment: Reactome DB_ID: 5591619
display name: COX15

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233032
data source: Provenance1
name: Cytochrome P450 26B1
name: DDB0233032
name: C26A_HUMAN
xref: UnificationXref8128
feature: FragmentFeature1342
cellular location: GO_0005789
comment: Reactome DB_ID: 5585486
display name: CYP26B1

Dimethylaniline monooxygenase (N-oxide-forming) 1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188649
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0188649
xref: UnificationXref8144
feature: FragmentFeature1343
cellular location: GO_0005788
comment: Reactome DB_ID: 5585504
display name: FMO1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188580
data source: Provenance1
name: Dimethylaniline monooxygenase (N-oxide-forming) 2
name: DDB0188580
xref: UnificationXref8155
feature: FragmentFeature1344
cellular location: GO_0005789
comment: Reactome DB_ID: 5585511
display name: FMO2

DDB0231418
type: Protein
entity reference: UniProt:DDB0231418
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
xref: UnificationXref8043
feature: FragmentFeature1336
cellular location: GO_0005829
comment: Reactome DB_ID: 5583814
display name: UROD

DDB0231417
type: Protein
entity reference: UniProt:DDB0231417
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HEM3_HUMAN
name: Porphobilinogen deaminase
xref: UnificationXref8029
feature: FragmentFeature1335
cellular location: GO_0005829
comment: Reactome DB_ID: 5583793
display name: HMBS

Protoporphyrinogen oxidase
type: Protein
entity reference: UniProt:DDB0231419
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0231419
name: PPOX_HUMAN
xref: UnificationXref8075
feature: FragmentFeature1338
cellular location: GO_0005758
comment: Reactome DB_ID: 5583807
display name: PPOX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231414
data source: Provenance1
name: HEM6_HUMAN
name: DDB0231414
name: Coproporphyrinogen III oxidase, mitochondrial
name: CPOX(132-454)
xref: UnificationXref8067
feature: FragmentFeature1337
cellular location: GO_0005758
comment: Reactome DB_ID: 5583800
display name: CPOX

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 127

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 275

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 210

herbimycin
type: SmallMoleculeReference
name: herbimycin [ChEBI:5674]
xref: UnificationXref1714

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 1174

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 117

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184083
data source: Provenance1
name: rhodanase
name: DDB0184083
xref: UnificationXref7969
feature: FragmentFeature1330
cellular location: GO_0005759
comment: Reactome DB_ID: 5589724
display name: TST

DDB0206266
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0206266
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: sulfite oxidase
xref: UnificationXref7979
feature: FragmentFeature1331
cellular location: GO_0005759
comment: Reactome DB_ID: 5589689
display name: SUOX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252562
data source: Provenance1
name: DDB0252562
name: SQRDL(1-450)
xref: UnificationXref7959
feature: FragmentFeature1328
cellular location: GO_0005743
comment: Reactome DB_ID: 5589712
display name: SQR(red.)

DDB0230991
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230991
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: sulfur dioxygenase
name: ETHE1
xref: UnificationXref7961
feature: FragmentFeature1329
cellular location: GO_0005759
comment: Reactome DB_ID: 5589716
display name: SO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231415
data source: Provenance1
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
name: DDB0231415
xref: UnificationXref8013
feature: FragmentFeature1334
cellular location: GO_0005829
comment: Reactome DB_ID: 5583821
display name: ALAD

5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor)
type: Protein
entity reference: UniProt:DDB0231416
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PXLP-ALAS1
name: 5-aminolevulinate synthase, non-specific, mitochondrial
name: DDB0231416
name: HEM1_HUMAN
xref: UnificationXref7999
feature: FragmentFeature1332
feature: ModificationFeature220
cellular location: GO_0005759
comment: Reactome DB_ID: 5583829
display name: ALAS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231416
data source: Provenance1
name: 5-aminolevulinate synthase, erythroid (pyridoxal phosphate cofactor)
name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor
name: HEM0_HUMAN
name: PXLP-ALAS2
name: DDB0231416
xref: UnificationXref8001
feature: FragmentFeature1333
feature: ModificationFeature220
cellular location: GO_0005759
comment: Reactome DB_ID: 5583831
display name: ALAS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252562
data source: Provenance1
name: CysS-SQRDL(1-450)
name: DDB0252562
xref: UnificationXref7952
feature: ModificationFeature219
feature: FragmentFeature1327
cellular location: GO_0005743
comment: Reactome DB_ID: 5589711
display name: SQR-S-SH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252562
data source: Provenance1
name: 2xHC-SQRDL(1-450)
name: DDB0252562
xref: UnificationXref7951
feature: FragmentFeature1326
feature: ModificationFeature217
feature: ModificationFeature218
cellular location: GO_0005743
comment: Reactome DB_ID: 5589738
display name: SQR(ox.)

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0231093
data source: Provenance1
name: Cysteine dioxygenase type 1
name: DDB0231093
xref: UnificationXref7932
feature: FragmentFeature1325
cellular location: GO_0005829
comment: Reactome DB_ID: 5589732
display name: CDO1

UniProt:DDB0231256
type: ProteinReference
xref: UnificationXref12309
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231259
type: ProteinReference
xref: UnificationXref1191
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231258
type: ProteinReference
xref: UnificationXref12033
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231253
type: ProteinReference
xref: UnificationXref12031
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266959
type: ProteinReference
xref: UnificationXref13015
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231251
type: ProteinReference
xref: UnificationXref12317
organism: http://identifiers.org/taxonomy/44689

Acyl chain remodelling of PE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction454
pathway component: BiochemicalReaction456
pathway component: BiochemicalReaction455
evidence: Evidence714
xref: UnificationXref5123
xref: RelationshipXref631
xref: UnificationXref5122
pathway order: PathwayStep691
pathway order: PathwayStep692
pathway order: PathwayStep693
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266960
type: ProteinReference
xref: UnificationXref13013
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/7317031
type: PublicationXref
id: 7317031
author: Orford, C R
author: Scott, J E
db: Pubmed
title: Dermatan sulphate-rich proteoglycan associates with rat tail-tendon collagen at the d band in the gap region
source: Biochem. J. 197:213-6
year: 1981

UniProt:DDB0231248
type: ProteinReference
xref: UnificationXref12193
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231247
type: ProteinReference
xref: UnificationXref12390
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231246
type: ProteinReference
xref: UnificationXref12380
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231245
type: ProteinReference
xref: UnificationXref12204
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231244
type: ProteinReference
xref: UnificationXref2762
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231243
type: ProteinReference
xref: UnificationXref12215
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231242
type: ProteinReference
xref: UnificationXref1197
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231241
type: ProteinReference
xref: UnificationXref1222
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231240
type: ProteinReference
xref: UnificationXref14554
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/17477549
type: PublicationXref
id: 17477549
author: Wolthers, Kirsten R
author: Scrutton, Nigel S
db: Pubmed
title: Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
source: Biochemistry 46:6696-709
year: 2007

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

Homologues of ABCB1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8440
cellular location: GO_0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589288

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216383
data source: Provenance1
name: DDB0216383
name: HC-ABCG2
xref: UnificationXref8434
feature: ModificationFeature221
feature: FragmentFeature1368
cellular location: GO_0005886
comment: Reactome DB_ID: 5588330
display name: ABCG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305275
data source: Provenance1
name: DDB0305275
name: Adrenodoxin, mitochondrial
name: Ferredoxin 1
name: ADX_HUMAN
xref: UnificationXref8397
feature: FragmentFeature1367
cellular location: GO_0005759
comment: Reactome DB_ID: 5589105
display name: FDX1

http://identifiers.org/pubmed/18555778
type: PublicationXref
id: 18555778
author: Aarden, Lucien A
author: Mooi, Wolter J
author: Vredeveld, Liesbeth C W
author: Michaloglou, Chrysiis
author: Peeper, Daniel S
author: Douma, Sirith
author: Desmet, Christophe J
author: Kuilman, Thomas
author: van Doorn, Remco
db: Pubmed
title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
source: Cell 133:1019-31
year: 2008

http://identifiers.org/pubmed/18555777
type: PublicationXref
id: 18555777
author: Augert, Arnaud
author: Popov, Nikolay
author: Takatsu, Yoshihiro
author: Gil, Jesús
author: Acosta, Juan C
author: Banito, Ana
author: Da Costa, Marco
author: Melamed, Jonathan
author: Guijarro, Maria V
author: Raguz, Selina
author: Fumagalli, Marzia
author: Brown, Celia
author: O'Loghlen, Ana
author: Hernando, Eva
author: d'Adda di Fagagna, Fabrizio
author: Bernard, David
db: Pubmed
title: Chemokine signaling via the CXCR2 receptor reinforces senescence
source: Cell 133:1006-18
year: 2008

UniProt:DDB0231269
type: ProteinReference
xref: UnificationXref12226
organism: http://identifiers.org/taxonomy/44689

DDB0237598
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237598
data source: Provenance1
name: MFRN2_HUMAN
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitoferrin-2
xref: UnificationXref8368
feature: FragmentFeature1361
cellular location: GO_0005743
comment: Reactome DB_ID: 5589118
display name: SLC25A28

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266646
data source: Provenance1
name: FRDA_HUMAN
name: FXN(81-210)
name: FXN (81-210)
name: DDB0266646
name: Frataxin, mature
xref: UnificationXref8373
feature: FragmentFeature1362
cellular location: GO_0005759
comment: Reactome DB_ID: 5589097
display name: FXN

DDB0237598
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237598
data source: Provenance1
name: MFRN1_HUMAN
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitoferrin-1
xref: UnificationXref8367
feature: FragmentFeature1360
cellular location: GO_0005743
comment: Reactome DB_ID: 5589117
display name: SLC25A37

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185317
data source: Provenance1
name: DDB0185317
name: ISCU_HUMAN
name: ISCU, mitochondrial
name: ISCU-1
name: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
name: ISCU isoform 1
xref: UnificationXref8381
feature: FragmentFeature1365
cellular location: GO_0005759
comment: Reactome DB_ID: 5589092
display name: ISCU2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234047
data source: Provenance1
name: Ferredoxin reductase
name: DDB0234047
name: ADRO_HUMAN
name: NADPH:adrenodoxin oxidoreductase, mitochondrial
xref: UnificationXref8388
feature: FragmentFeature1366
cellular location: GO_0005759
comment: Reactome DB_ID: 5591057
display name: FDXR

LYRM4_HUMAN
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232412
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LYRM4 (ISD11)
name: DDB0232412
name: LYR motif-containing protein 4
xref: UnificationXref8375
feature: FragmentFeature1363
cellular location: GO_0005759
comment: Reactome DB_ID: 5589096
display name: LYRM4

UniProt:DDB0231263
type: ProteinReference
xref: UnificationXref12049
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232198
data source: Provenance1
name: Cysteine desulfurase, mitochondrial
name: NFS1, mitochondrial (ISCS)
name: DDB0232198
name: NFS1_HUMAN
name: NSF1 isoform 1
xref: UnificationXref8376
feature: FragmentFeature1364
cellular location: GO_0005759
comment: Reactome DB_ID: 5589099
display name: NFS1-1

UniProt:DDB0231210
type: ProteinReference
xref: UnificationXref8787
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

UniProt:DDB0231216
type: ProteinReference
xref: UnificationXref13609
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231217
type: ProteinReference
xref: UnificationXref13595
organism: http://identifiers.org/taxonomy/44689

Mitochondrial ornithine transporters
type: Protein
data source: Provenance1
member physical entity: DDB0234097
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7588
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5579251

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237597
data source: Provenance1
name: DDB0237597
name: Solute carrier family 25, member 15
name: Mitochondrial ornithine transporter 1
xref: UnificationXref7585
feature: FragmentFeature1287
cellular location: GO_0005743
comment: Reactome DB_ID: 5579246
display name: SLC25A15

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266468
data source: Provenance1
name: DDB0266468
name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
xref: UnificationXref7557
feature: FragmentFeature1285
cellular location: GO_0005829
comment: Reactome DB_ID: 5579678
display name: ACMSD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231459
data source: Provenance1
name: NAGS(19-534)
name: DDB0231459
name: N-acetylglutamate synthetase
xref: UnificationXref7573
feature: FragmentFeature1286
cellular location: GO_0005759
comment: Reactome DB_ID: 5579186
display name: NAGS

DDB0231361
type: Protein
entity reference: UniProt:DDB0231361
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PXLP-KYNU
name: L-kynurenine hydrolase
name: kynureninase
xref: UnificationXref7541
feature: ModificationFeature213
feature: FragmentFeature1283
cellular location: GO_0005829
comment: Reactome DB_ID: 5579664
display name: KYNU

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231359
data source: Provenance1
name: 3-hydroxyanthranilic acid dioxygenase
name: 3-HAO
name: 3-hydroxyanthranilate 3,4-dioxygenase
name: 3-hydroxyanthranilate oxygenase
name: DDB0231359
xref: UnificationXref7549
feature: FragmentFeature1284
cellular location: GO_0005829
comment: Reactome DB_ID: 5579671
display name: HAAO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0231138
data source: Provenance1
name: Kynurenine--oxoglutarate transaminase 3
name: PXLP-CCBL2
name: DDB0231138
name: CCBL2
xref: UnificationXref7526
feature: ModificationFeature212
feature: FragmentFeature1281
cellular location: GO_0005829
comment: Reactome DB_ID: 5588208
display name: KAT3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231360
data source: Provenance1
name: DDB0231360
name: kynurenine 3-monooxygenase
xref: UnificationXref7534
feature: FragmentFeature1282
cellular location: GO_0005829
comment: Reactome DB_ID: 5579657
display name: KMO

PUT2_HUMAN
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229934
data source: Provenance1
name: P5C dehydrogenase monomer
name: DDB0229934
name: Note: the coordinates are copied over from Homo sapiens.
name: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
name: P5C dehydrogenase
xref: UnificationXref7509
feature: FragmentFeature1279
cellular location: GO_0005759
comment: Reactome DB_ID: 5579284
display name: ALDH4A1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231363
data source: Provenance1
name: Tryptamin 2,3-dioxygenase
name: Tryptophanase
name: DDB0231363
name: Tryptophan oxygenase
name: tryptophan oxygenase
name: Tryptophan pyrrolase
name: tryptophan 2,3-dioxygenase
name: TRPO
xref: UnificationXref7522
feature: FragmentFeature1280
cellular location: GO_0005829
comment: Reactome DB_ID: 5579650
display name: TDO2

UniProt:DDB0231238
type: ProteinReference
xref: UnificationXref14556
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

UniProt:DDB0231221
type: ProteinReference
xref: UnificationXref13607
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231222
type: ProteinReference
xref: UnificationXref13599
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231225
type: ProteinReference
xref: UnificationXref2785
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231226
type: ProteinReference
xref: UnificationXref2749
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/11851405
type: PublicationXref
id: 11851405
author: Lin, Zheng
author: Liu, Alice Y-C
author: Manalo, Dominador J
db: Pubmed
title: Redox-dependent regulation of the conformation and function of human heat shock factor 1
source: Biochemistry 41:2580-8
year: 2002

DDB0238431
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238431
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: D-amino-acid oxidase
xref: UnificationXref7841
feature: FragmentFeature1315
cellular location: GO_0005782
comment: Reactome DB_ID: 5586373
display name: DAO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237978
data source: Provenance1
name: Alanine-glyoxylate aminotransferase
name: PXLP-AGXT
name: DDB0237978
name: Serine-pyruvate aminotransferase
xref: UnificationXref7852
feature: ModificationFeature215
feature: FragmentFeature1316
cellular location: GO_0005782
comment: Reactome DB_ID: 5586361
display name: AGXT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0205702
data source: Provenance1
name: CNDP2_HUMAN
name: DDB0205702
name: Cytosolic non-specific dipeptidase
xref: UnificationXref7917
feature: FragmentFeature1324
cellular location: GO_0005829
comment: Reactome DB_ID: 5588983
display name: CNDP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191318
data source: Provenance1
name: Cystathionine gamma-lyase
name: DDB0191318
xref: UnificationXref7907
feature: FragmentFeature1323
cellular location: GO_0005829
comment: Reactome DB_ID: 5589697
display name: CTH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191292
data source: Provenance1
name: PXLP-CBS
name: DDB0191292
name: Cystathionine beta-synthase
xref: UnificationXref7899
feature: FragmentFeature1322
feature: ModificationFeature216
cellular location: GO_0005829
comment: Reactome DB_ID: 5589682
display name: CBS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191108
data source: Provenance1
name: SAH hydrolase
name: DDB0191108
xref: UnificationXref7890
feature: FragmentFeature1321
cellular location: GO_0005829
comment: Reactome DB_ID: 5583607
display name: AHCY

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231749
data source: Provenance1
name: MAT2B isoform-1
name: DDB0231749
xref: UnificationXref7884
feature: FragmentFeature1320
cellular location: GO_0005829
comment: Reactome DB_ID: 5583589
display name: MAT2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230070
data source: Provenance1
name: MAT I/III
name: DDB0230070
xref: UnificationXref7879
feature: FragmentFeature1319
cellular location: GO_0005829
comment: Reactome DB_ID: 5583582
display name: MAT1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267054
data source: Provenance1
name: DDB0267054
name: HAOX1
name: Hydroxyacid oxidase 1
xref: UnificationXref7864
feature: FragmentFeature1318
cellular location: GO_0005782
comment: Reactome DB_ID: 5586388
display name: HAO1

DDB0231445
type: Protein
entity reference: UniProt:DDB0231445
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glyoxylate reductase/hydroxypyruvate reductase
xref: UnificationXref7860
feature: FragmentFeature1317
cellular location: GO_0005782
comment: Reactome DB_ID: 5586382
display name: GRHPR

Cysteine formation from homocysteine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction797
pathway component: BiochemicalReaction798
evidence: Evidence1154
xref: UnificationXref7911
xref: UnificationXref7912
xref: RelationshipXref1154
pathway order: PathwayStep1132
pathway order: PathwayStep1133
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2700
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 21.0

Stoichiometry2702
type: Stoichiometry
physical entity: Protein2453
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229899
data source: Provenance1
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
name: DDB0229899
xref: UnificationXref7809
feature: FragmentFeature1306
cellular location: GO_0005829
comment: Reactome DB_ID: 5585426
display name: ASMT

Stoichiometry2701
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266733
data source: Provenance1
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: DDB0266733
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7821
feature: FragmentFeature1312
cellular location: GO_0005829
comment: Reactome DB_ID: 5585450
display name: ASMT

Stoichiometry2707
type: Stoichiometry
physical entity: Complex996
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219945
data source: Provenance1
name: DDB0219945
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7819
feature: FragmentFeature1311
cellular location: GO_0005829
comment: Reactome DB_ID: 5585446
display name: ASMT

Stoichiometry2708
type: Stoichiometry
physical entity: Protein2455
stoichiometric coefficient: 1.0

Homologues of DAO
type: Protein
data source: Provenance1
member physical entity: DDB0238431
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7842
cellular location: GO_0005782
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586374

Stoichiometry2709
type: Stoichiometry
physical entity: Complex991
stoichiometric coefficient: 1.0

DDB0266735
type: Protein
entity reference: UniProt:DDB0266735
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7823
feature: FragmentFeature1313
cellular location: GO_0005829
comment: Reactome DB_ID: 5585454
display name: ASMT

DDB0266734
type: Protein
entity reference: UniProt:DDB0266734
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7813
feature: FragmentFeature1308
cellular location: GO_0005829
comment: Reactome DB_ID: 5585434
display name: ASMT

Stoichiometry2703
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266730
data source: Provenance1
name: DDB0266730
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7811
feature: FragmentFeature1307
cellular location: GO_0005829
comment: Reactome DB_ID: 5585430
display name: ASMT

Stoichiometry2704
type: Stoichiometry
physical entity: Protein2454
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231349
data source: Provenance1
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
name: DDB0231349
xref: UnificationXref7817
feature: FragmentFeature1310
cellular location: GO_0005829
comment: Reactome DB_ID: 5585442
display name: ASMT

Stoichiometry2705
type: Stoichiometry
physical entity: PhysicalEntity185
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266732
data source: Provenance1
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: DDB0266732
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref7815
feature: FragmentFeature1309
cellular location: GO_0005829
comment: Reactome DB_ID: 5585438
display name: ASMT

Stoichiometry2706
type: Stoichiometry
physical entity: Complex998
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238432
data source: Provenance1
name: DDB0238432
name: D-amino-acid oxidase
xref: UnificationXref7839
feature: FragmentFeature1314
cellular location: GO_0005782
comment: Reactome DB_ID: 5586369
display name: DAO

Stoichiometry2713
type: Stoichiometry
physical entity: Protein2457
stoichiometric coefficient: 1.0

Stoichiometry2712
type: Stoichiometry
physical entity: Complex1000
stoichiometric coefficient: 1.0

Stoichiometry2711
type: Stoichiometry
physical entity: Protein2456
stoichiometric coefficient: 1.0

Stoichiometry2710
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 3.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191269
data source: Provenance1
name: PERT_HUMAN
name: Thyroid peroxidase
name: DDB0191269
xref: UnificationXref7745
feature: FragmentFeature1301
cellular location: GO_0005886
comment: Reactome DB_ID: 5585420
display name: TPO

Stoichiometry2716
type: Stoichiometry
physical entity: Protein2460
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231664
data source: Provenance1
name: TY3H_HUMAN
name: DDB0231664
name: Tyrosine 3-monooxygenase ecNumber1.14.16.2/ecNumber
xref: UnificationXref7728
feature: FragmentFeature1300
cellular location: GO_0005829
comment: Reactome DB_ID: 5585458
display name: TH

Stoichiometry2717
type: Stoichiometry
physical entity: Complex1001
stoichiometric coefficient: 1.0

ADI1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230998
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230998
xref: UnificationXref7711
feature: FragmentFeature1299
cellular location: GO_0005829
comment: Reactome DB_ID: 5588961
display name: ARD

Stoichiometry2714
type: Stoichiometry
physical entity: Protein2458
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230999
data source: Provenance1
name: DDB0230999
name: ENOPH1
xref: UnificationXref7703
feature: FragmentFeature1298
cellular location: GO_0005829
comment: Reactome DB_ID: 5588968
display name: E1

Stoichiometry2715
type: Stoichiometry
physical entity: Protein2459
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231664
data source: Provenance1
name: DDB0231664
name: Tryptophan 5-hydroxylase 1
name: TPH1_HUMAN
xref: UnificationXref7796
feature: FragmentFeature1304
cellular location: GO_0005829
comment: Reactome DB_ID: 5585462
display name: TPH1

Tryptophan 5-hydroxylase
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7798
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5585464
display name: TPH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234079
data source: Provenance1
name: DDB0234079
name: Type III iodothyronine deiodinase
xref: UnificationXref7786
feature: FragmentFeature1303
cellular location: GO_0005886
comment: Reactome DB_ID: 5585614
display name: DIO3

Stoichiometry2718
type: Stoichiometry
physical entity: PhysicalEntity186
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234079
data source: Provenance1
name: DDB0234079
name: IOD1_HUMAN
name: Type I iodothyronine deiodinase
xref: UnificationXref7782
feature: FragmentFeature1302
cellular location: GO_0005886
comment: Reactome DB_ID: 5585413
display name: DIO1

Stoichiometry2719
type: Stoichiometry
physical entity: Protein2461
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/18367646
type: PublicationXref
id: 18367646
author: Ji, JY
author: Herr, A
author: Longworth, Michelle
author: Dyson, NJ
db: Pubmed
title: RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
source: Genes Dev 22:1011-24
year: 2008

Homologues of ASMT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0266735
member physical entity: DDB0266734
xref: UnificationXref7824
cellular location: GO_0005829
comment: Reactome DB_ID: 5585455
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231664
data source: Provenance1
name: DDB0231664
xref: UnificationXref7797
feature: FragmentFeature1305
cellular location: GO_0005829
comment: Reactome DB_ID: 5585463
display name: TPH2

Stoichiometry2720
type: Stoichiometry
physical entity: Protein2462
stoichiometric coefficient: 1.0

Stoichiometry2722
type: Stoichiometry
physical entity: Complex1002
stoichiometric coefficient: 1.0

Stoichiometry2721
type: Stoichiometry
physical entity: Protein2463
stoichiometric coefficient: 1.0

Stoichiometry2724
type: Stoichiometry
physical entity: Protein2465
stoichiometric coefficient: 1.0

Stoichiometry2723
type: Stoichiometry
physical entity: Protein2464
stoichiometric coefficient: 1.0

DDB0234097
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234097
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitochondrial ornithine transporter 2
name: Solute carrier family 25, member 2
xref: UnificationXref7587
feature: FragmentFeature1288
cellular location: GO_0005743
comment: Reactome DB_ID: 5579250
display name: SLC25A2

Stoichiometry2725
type: Stoichiometry
physical entity: Protein2466
stoichiometric coefficient: 1.0

Stoichiometry2726
type: Stoichiometry
physical entity: Complex1003
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237755
data source: Provenance1
name: PXLP-ODC1
name: ornithine decarboxylase
name: DDB0237755
xref: UnificationXref7616
feature: ModificationFeature214
feature: FragmentFeature1290
cellular location: GO_0005829
comment: Reactome DB_ID: 5579292
display name: ODC

Stoichiometry2727
type: Stoichiometry
physical entity: Protein2431
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237756
data source: Provenance1
name: Arginine decarboxylase
name: DDB0237756
name: ADC_HUMAN
xref: UnificationXref7607
feature: FragmentFeature1289
cellular location: GO_0005829
comment: Reactome DB_ID: 5585604
display name: ADC

Stoichiometry2728
type: Stoichiometry
physical entity: Complex992
stoichiometric coefficient: 1.0

Spermidine synthase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191167
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0191167
xref: UnificationXref7633
feature: FragmentFeature1292
cellular location: GO_0005829
comment: Reactome DB_ID: 5585628
display name: SRM

Stoichiometry2729
type: Stoichiometry
physical entity: Protein2432
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237590
data source: Provenance1
name: DDB0237590
name: AMD1(1-67)
xref: UnificationXref7623
feature: FragmentFeature1291
cellular location: GO_0005829
comment: Reactome DB_ID: 5585634
display name: AdoMetDC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231714
data source: Provenance1
name: PAOX
name: DDB0231714
xref: UnificationXref7651
feature: FragmentFeature1294
cellular location: GO_0005782
comment: Reactome DB_ID: 5582668
display name: PAO

http://identifiers.org/pubmed/10620514
type: PublicationXref
id: 10620514
author: Alonso, FJ
author: Campos, JA
author: Marquez, J
author: Del Castillo-Olivares, A
author: Aledo, JC
author: Gomez-Fabre, PM
author: Nunez De Castro, I
db: Pubmed
title: Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase
source: Biochem J 345:365-75
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233628
data source: Provenance1
name: SSAT-1
name: DDB0233628
xref: UnificationXref7640
feature: FragmentFeature1293
cellular location: GO_0005829
comment: Reactome DB_ID: 5585621
display name: SAT1

DDB0231374
type: Protein
entity reference: UniProt:DDB0231374
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: M1PI
xref: UnificationXref7686
feature: FragmentFeature1296
cellular location: GO_0005829
comment: Reactome DB_ID: 5588953
display name: MRI1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231714
data source: Provenance1
name: SMOX_HUMAN
name: DDB0231714
name: Spermine oxidase ecNumber1.5.3.16/ecNumber
xref: UnificationXref7674
feature: FragmentFeature1295
cellular location: GO_0005829
comment: Reactome DB_ID: 5582665
display name: SMOX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233078
data source: Provenance1
name: DDB0233078
xref: UnificationXref7695
feature: FragmentFeature1297
cellular location: GO_0005829
comment: Reactome DB_ID: 5588975
display name: APIP

UnificationXref2618
type: UnificationXref
id: REACT_225166
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_225166.2

UnificationXref2619
type: UnificationXref
id: 5579763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579763

UnificationXref2616
type: UnificationXref
id: REACT_207123
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207123.2

UnificationXref2617
type: UnificationXref
id: 5579173
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579173

UnificationXref2614
type: UnificationXref
id: 5581435
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581435

SequenceSite4580
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2615
type: UnificationXref
id: 5585744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585744

SequenceSite4581
type: SequenceSite
position status: EQUAL
sequence position: 528

UnificationXref2612
type: UnificationXref
id: REACT_4667
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4667.2

UnificationXref2613
type: UnificationXref
id: DDB0229992
db: UniProt

SequenceSite4584
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite4585
type: SequenceSite
position status: EQUAL
sequence position: 985

SequenceSite4582
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4583
type: SequenceSite
position status: EQUAL
sequence position: 1264

SequenceSite4588
type: SequenceSite
position status: EQUAL
sequence position: 15

SequenceSite4589
type: SequenceSite
position status: EQUAL
sequence position: 477

SequenceSite4586
type: SequenceSite
position status: EQUAL
sequence position: 17

SequenceSite4587
type: SequenceSite
position status: EQUAL
sequence position: 578

Stoichiometry2880
type: Stoichiometry
physical entity: Complex1043
stoichiometric coefficient: 1.0

Stoichiometry2881
type: Stoichiometry
physical entity: Protein2525
stoichiometric coefficient: 1.0

SequenceSite4579
type: SequenceSite
position status: EQUAL
sequence position: 471

UnificationXref2611
type: UnificationXref
id: 29654
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29654

Stoichiometry2888
type: Stoichiometry
physical entity: Protein2531
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/21356517
type: PublicationXref
id: 21356517
author: Roach, PJ
author: Glushka, John
author: Contreras, Christopher J
author: Ishihara, Mayumi
author: Heiss, Christian
author: Tagliabracci, Vincent S
author: Hurley, TD
author: Karthik, Chandra
author: Azadi, Parastoo
author: DePaoli-Roach, Anna A
db: Pubmed
title: Phosphate incorporation during glycogen synthesis and Lafora disease
source: Cell Metab. 13:274-82
year: 2011

UnificationXref2610
type: UnificationXref
id: REACT_204139
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204139.2

Stoichiometry2889
type: Stoichiometry
physical entity: Protein2532
stoichiometric coefficient: 1.0

Stoichiometry2886
type: Stoichiometry
physical entity: Protein2529
stoichiometric coefficient: 1.0

Stoichiometry2887
type: Stoichiometry
physical entity: Protein2530
stoichiometric coefficient: 1.0

Stoichiometry2884
type: Stoichiometry
physical entity: Protein2528
stoichiometric coefficient: 1.0

Stoichiometry2885
type: Stoichiometry
physical entity: PhysicalEntity9
stoichiometric coefficient: 1.0

Stoichiometry2882
type: Stoichiometry
physical entity: Protein2526
stoichiometric coefficient: 1.0

Stoichiometry2883
type: Stoichiometry
physical entity: Protein2527
stoichiometric coefficient: 1.0

UnificationXref2627
type: UnificationXref
id: 5579764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579764

UnificationXref2628
type: UnificationXref
id: REACT_259816
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259816.1

UnificationXref2629
type: UnificationXref
id: DDB0216231
db: UniProt

UnificationXref2623
type: UnificationXref
id: 5579156
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579156

UnificationXref2624
type: UnificationXref
id: REACT_100121
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100121.4

Stoichiometry2879
type: Stoichiometry
physical entity: Protein2524
stoichiometric coefficient: 1.0

UnificationXref2625
type: UnificationXref
id: 5579155
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579155

UnificationXref2626
type: UnificationXref
id: REACT_240237
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240237.1

SequenceSite4570
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4571
type: SequenceSite
position status: EQUAL
sequence position: 589

http://identifiers.org/pubmed/1939222
type: PublicationXref
id: 1939222
author: Cox, TM
author: Gardner, LC
author: Smith, SJ
db: Pubmed
title: Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
source: J Biol Chem 266:22010-8
year: 1991

SequenceSite4572
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

SequenceSite4573
type: SequenceSite
position status: EQUAL
sequence position: 508

SequenceSite4574
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4575
type: SequenceSite
position status: EQUAL
sequence position: 514

SequenceSite4576
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4577
type: SequenceSite
position status: EQUAL
sequence position: 723

SequenceSite4578
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4569
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite4568
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry2870
type: Stoichiometry
physical entity: Protein2514
stoichiometric coefficient: 2.0

UnificationXref2620
type: UnificationXref
id: REACT_196089
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_196089.3

Stoichiometry2875
type: Stoichiometry
physical entity: Protein2520
stoichiometric coefficient: 1.0

Stoichiometry2876
type: Stoichiometry
physical entity: Protein2521
stoichiometric coefficient: 1.0

UnificationXref2622
type: UnificationXref
id: REACT_197439
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197439.3

Stoichiometry2877
type: Stoichiometry
physical entity: Protein2522
stoichiometric coefficient: 1.0

UnificationXref2621
type: UnificationXref
id: 5579163
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579163

Stoichiometry2878
type: Stoichiometry
physical entity: Protein2523
stoichiometric coefficient: 1.0

Stoichiometry2871
type: Stoichiometry
physical entity: Protein2516
stoichiometric coefficient: 1.0

Stoichiometry2872
type: Stoichiometry
physical entity: Protein2517
stoichiometric coefficient: 1.0

Stoichiometry2873
type: Stoichiometry
physical entity: Protein2518
stoichiometric coefficient: 1.0

Stoichiometry2874
type: Stoichiometry
physical entity: Protein2519
stoichiometric coefficient: 1.0

Stoichiometry2869
type: Stoichiometry
physical entity: Protein2511
stoichiometric coefficient: 2.0

Stoichiometry2868
type: Stoichiometry
physical entity: Protein2507
stoichiometric coefficient: 2.0

SequenceSite4566
type: SequenceSite
position status: EQUAL
sequence position: 55

SequenceSite4567
type: SequenceSite
position status: EQUAL
sequence position: 739

SequenceSite4564
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

SequenceSite4565
type: SequenceSite
position status: EQUAL
sequence position: 748

SequenceSite4562
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4563
type: SequenceSite
position status: EQUAL
sequence position: 548

SequenceSite4560
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4561
type: SequenceSite
position status: EQUAL
sequence position: 1512

SequenceSite4559
type: SequenceSite
position status: EQUAL
sequence position: 597

SequenceSite4558
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4557
type: SequenceSite
position status: EQUAL
sequence position: 312

Stoichiometry2862
type: Stoichiometry
physical entity: Protein2491
stoichiometric coefficient: 2.0

Stoichiometry2863
type: Stoichiometry
physical entity: Protein2492
stoichiometric coefficient: 2.0

Stoichiometry2860
type: Stoichiometry
physical entity: Protein2489
stoichiometric coefficient: 2.0

Stoichiometry2861
type: Stoichiometry
physical entity: Protein2490
stoichiometric coefficient: 2.0

Stoichiometry2866
type: Stoichiometry
physical entity: Protein2499
stoichiometric coefficient: 2.0

Stoichiometry2867
type: Stoichiometry
physical entity: Protein2503
stoichiometric coefficient: 2.0

Stoichiometry2864
type: Stoichiometry
physical entity: Protein2493
stoichiometric coefficient: 2.0

Stoichiometry2865
type: Stoichiometry
physical entity: Protein2494
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

UnificationXref2601
type: UnificationXref
id: REACT_2373
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2373.1

Stoichiometry2858
type: Stoichiometry
physical entity: Protein2486
stoichiometric coefficient: 2.0

UnificationXref2602
type: UnificationXref
id: 5579015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579015

Stoichiometry2857
type: Stoichiometry
physical entity: Protein2484
stoichiometric coefficient: 1.0

UnificationXref2603
type: UnificationXref
id: REACT_252127
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252127.1

UnificationXref2604
type: UnificationXref
id: 29376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376

Stoichiometry2859
type: Stoichiometry
physical entity: Protein2487
stoichiometric coefficient: 2.0

UnificationXref2605
type: UnificationXref
id: REACT_2572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2572.1

UnificationXref2606
type: UnificationXref
id: 372364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=372364

UnificationXref2607
type: UnificationXref
id: REACT_14919
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14919.2

UnificationXref2608
type: UnificationXref
id: 5585751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585751

UnificationXref2609
type: UnificationXref
id: 5585753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585753

SequenceSite4553
type: SequenceSite
position status: EQUAL
sequence position: 501

SequenceSite4554
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4555
type: SequenceSite
position status: EQUAL
sequence position: 501

SequenceSite4556
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4550
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4551
type: SequenceSite
position status: EQUAL
sequence position: 660

SequenceSite4552
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4547
type: SequenceSite
position status: EQUAL
sequence position: 775

SequenceSite4546
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4549
type: SequenceSite
position status: EQUAL
sequence position: 900

SequenceSite4548
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2850
type: Stoichiometry
physical entity: Protein2478
stoichiometric coefficient: 1.0

Stoichiometry2851
type: Stoichiometry
physical entity: PhysicalEntity9
stoichiometric coefficient: 2.0

Stoichiometry2852
type: Stoichiometry
physical entity: Protein2479
stoichiometric coefficient: 2.0

Stoichiometry2853
type: Stoichiometry
physical entity: Complex1028
stoichiometric coefficient: 1.0

Stoichiometry2854
type: Stoichiometry
physical entity: Protein2482
stoichiometric coefficient: 1.0

UnificationXref2600
type: UnificationXref
id: 113528
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113528

Stoichiometry2855
type: Stoichiometry
physical entity: Protein2483
stoichiometric coefficient: 2.0

Stoichiometry2856
type: Stoichiometry
physical entity: Complex1029
stoichiometric coefficient: 1.0

UnificationXref2659
type: UnificationXref
id: REACT_3409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3409.1

UnificationXref2658
type: UnificationXref
id: 29494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29494

UnificationXref2657
type: UnificationXref
id: REACT_248272
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248272.1

UnificationXref2656
type: UnificationXref
id: 5579036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579036

UnificationXref2654
type: UnificationXref
id: 5579033
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579033

UnificationXref2655
type: UnificationXref
id: 5579034
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579034

UnificationXref2652
type: UnificationXref
id: DDB0238765
db: UniProt

UnificationXref2653
type: UnificationXref
id: 5579032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579032

UnificationXref2650
type: UnificationXref
id: 5579027
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579027

UnificationXref2651
type: UnificationXref
id: 5579028
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579028

UnificationXref2668
type: UnificationXref
id: 5592295
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592295

UnificationXref2667
type: UnificationXref
id: REACT_240076
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240076.1

UnificationXref2669
type: UnificationXref
id: REACT_176277
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176277.3

UnificationXref2663
type: UnificationXref
id: 5579044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579044

UnificationXref2664
type: UnificationXref
id: 5579045
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579045

UnificationXref2665
type: UnificationXref
id: 5579046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579046

UnificationXref2666
type: UnificationXref
id: 5579048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579048

UnificationXref2660
type: UnificationXref
id: DDB0191527
db: UniProt

UnificationXref2661
type: UnificationXref
id: 5579040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579040

UnificationXref2662
type: UnificationXref
id: DDB0214911
db: UniProt

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

UnificationXref2637
type: UnificationXref
id: 5579154
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579154

UnificationXref2636
type: UnificationXref
id: REACT_233469
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233469.1

UnificationXref2635
type: UnificationXref
id: 5579153
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579153

UnificationXref2634
type: UnificationXref
id: 5579151
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579151

UnificationXref2639
type: UnificationXref
id: REACT_235866
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235866.1

UnificationXref2638
type: UnificationXref
id: 5583090
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5583090

UnificationXref2632
type: UnificationXref
id: 5579149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579149

UnificationXref2633
type: UnificationXref
id: 5579150
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579150

UnificationXref2630
type: UnificationXref
id: 5579147
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579147

UnificationXref2631
type: UnificationXref
id: 5579148
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579148

SequenceSite4598
type: SequenceSite
position status: EQUAL
sequence position: 34

SequenceSite4597
type: SequenceSite
position status: EQUAL
sequence position: 739

SequenceSite4599
type: SequenceSite
position status: EQUAL
sequence position: 506

SequenceSite4594
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4593
type: SequenceSite
position status: EQUAL
sequence position: 523

SequenceSite4596
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4595
type: SequenceSite
position status: EQUAL
sequence position: 775

UnificationXref2646
type: UnificationXref
id: CHEBI:16077
db: ChEBI

SequenceSite4590
type: SequenceSite
position status: EQUAL
sequence position: 48

UnificationXref2645
type: UnificationXref
id: REACT_260915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260915.1

UnificationXref2648
type: UnificationXref
id: REACT_5634
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5634.2

SequenceSite4592
type: SequenceSite
position status: EQUAL
sequence position: 42

UnificationXref2647
type: UnificationXref
id: 29548
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29548

SequenceSite4591
type: SequenceSite
position status: EQUAL
sequence position: 645

UnificationXref2649
type: UnificationXref
id: DDB0191348
db: UniProt

Stoichiometry2894
type: Stoichiometry
physical entity: Protein2535
stoichiometric coefficient: 1.0

Stoichiometry2893
type: Stoichiometry
physical entity: PhysicalEntity199
stoichiometric coefficient: 1.0

Stoichiometry2896
type: Stoichiometry
physical entity: Protein2537
stoichiometric coefficient: 1.0

UnificationXref2640
type: UnificationXref
id: 5579023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579023

Stoichiometry2895
type: Stoichiometry
physical entity: Protein2536
stoichiometric coefficient: 1.0

UnificationXref2641
type: UnificationXref
id: REACT_243337
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243337.1

Stoichiometry2898
type: Stoichiometry
physical entity: SmallMolecule55
stoichiometric coefficient: 1.0

UnificationXref2642
type: UnificationXref
id: 5579143
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579143

Stoichiometry2897
type: Stoichiometry
physical entity: Protein2538
stoichiometric coefficient: 1.0

UnificationXref2643
type: UnificationXref
id: REACT_249066
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249066.1

UnificationXref2644
type: UnificationXref
id: 5592288
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592288

Stoichiometry2899
type: Stoichiometry
physical entity: Complex1049
stoichiometric coefficient: 1.0

Stoichiometry2890
type: Stoichiometry
physical entity: Complex1044
stoichiometric coefficient: 1.0

Stoichiometry2892
type: Stoichiometry
physical entity: Complex1044
stoichiometric coefficient: 1.0

Stoichiometry2891
type: Stoichiometry
physical entity: PhysicalEntity197
stoichiometric coefficient: 1.0

UnificationXref2691
type: UnificationXref
id: REACT_177550
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177550.3

UnificationXref2690
type: UnificationXref
id: 5587744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587744

Asparagine N-linked glycosylation
type: Pathway
data source: Provenance1
pathway component: REACT 205024.2
pathway component: REACT 225919.2
pathway component: REACT 211684.2
evidence: Evidence2078
xref: UnificationXref13509
xref: UnificationXref13510
xref: RelationshipXref1636
pathway order: PathwayStep2030
pathway order: PathwayStep2021
pathway order: PathwayStep2040
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

UnificationXref2697
type: UnificationXref
id: REACT_242779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242779.1

UnificationXref2696
type: UnificationXref
id: 5592289
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592289

UnificationXref2699
type: UnificationXref
id: 31221
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31221

UnificationXref2698
type: UnificationXref
id: CHEBI:18105
db: ChEBI

UnificationXref2693
type: UnificationXref
id: REACT_250027
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250027.1

UnificationXref2692
type: UnificationXref
id: 5579100
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579100

UnificationXref2695
type: UnificationXref
id: REACT_236850
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_236850.1

UnificationXref2694
type: UnificationXref
id: 5592307
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592307

SequenceSite91
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite90
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite93
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite92
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite95
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite94
type: SequenceSite
position status: EQUAL
sequence position: 347

SequenceSite97
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite96
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite99
type: SequenceSite
position status: EQUAL
sequence position: 218

SequenceSite98
type: SequenceSite
position status: EQUAL
sequence position: 393

SequenceSite4500
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4501
type: SequenceSite
position status: EQUAL
sequence position: 531

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

http://identifiers.org/pubmed/17785525
type: PublicationXref
id: 17785525
author: Boyault, Cyril
author: Garrido, Carmen
author: Gilquin, Benoit
author: Kwon, So Hee
author: Caron, Cécile
author: Fritah, Sabrina
author: Khochbin, Saadi
author: Vourc'h, Claire
author: Yao, Tso-Pang
author: Matthias, Patrick
author: Zhang, Yu
db: Pubmed
title: HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
source: Genes Dev. 21:2172-81
year: 2007

Degradation of GABA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1040
pathway component: BiochemicalReaction1039
evidence: Evidence1579
xref: UnificationXref10389
xref: UnificationXref10388
pathway order: PathwayStep1547
pathway order: PathwayStep1548
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2671
type: UnificationXref
id: 5587733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587733

UnificationXref2670
type: UnificationXref
id: DDB0191397
db: UniProt

UnificationXref2673
type: UnificationXref
id: 5587734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587734

UnificationXref2672
type: UnificationXref
id: DDB0215010
db: UniProt

UnificationXref2675
type: UnificationXref
id: 5587736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587736

UnificationXref2674
type: UnificationXref
id: 5587735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587735

UnificationXref2677
type: UnificationXref
id: 5587750
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587750

UnificationXref2676
type: UnificationXref
id: 5587748
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587748

UnificationXref2678
type: UnificationXref
id: REACT_177543
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177543.3

UnificationXref2679
type: UnificationXref
id: 5587749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587749

UnificationXref2680
type: UnificationXref
id: REACT_177545
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177545.3

UnificationXref2684
type: UnificationXref
id: 5579777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579777

UnificationXref2683
type: UnificationXref
id: 5579776
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579776

UnificationXref2682
type: UnificationXref
id: 5579775
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579775

UnificationXref2681
type: UnificationXref
id: 5579770
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579770

UnificationXref2688
type: UnificationXref
id: 5587747
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587747

UnificationXref2687
type: UnificationXref
id: REACT_177548
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177548.3

UnificationXref2686
type: UnificationXref
id: 5587745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587745

UnificationXref2685
type: UnificationXref
id: 5587743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587743

UnificationXref2689
type: UnificationXref
id: 5587746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587746

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 580

SequenceSite4535
type: SequenceSite
position status: EQUAL
sequence position: 270

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4536
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4537
type: SequenceSite
position status: EQUAL
sequence position: 270

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4538
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4539
type: SequenceSite
position status: EQUAL
sequence position: 594

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 528

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 590

SequenceSite4541
type: SequenceSite
position status: EQUAL
sequence position: 968

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4540
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 431

SequenceSite4543
type: SequenceSite
position status: EQUAL
sequence position: 1176

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4542
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 427

SequenceSite4545
type: SequenceSite
position status: EQUAL
sequence position: 1262

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4544
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4526
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4527
type: SequenceSite
position status: EQUAL
sequence position: 425

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4524
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 424

SequenceSite4525
type: SequenceSite
position status: EQUAL
sequence position: 306

SequenceSite4528
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4529
type: SequenceSite
position status: EQUAL
sequence position: 1555

SequenceSite63
type: SequenceSite
position status: EQUAL
sequence position: 183

SequenceSite4530
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite64
type: SequenceSite
position status: EQUAL
sequence position: 185

SequenceSite61
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite62
type: SequenceSite
position status: EQUAL
sequence position: 427

SequenceSite67
type: SequenceSite
position status: EQUAL
sequence position: 221

SequenceSite4534
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite68
type: SequenceSite
position status: EQUAL
sequence position: 223

SequenceSite4533
type: SequenceSite
position status: EQUAL
sequence position: 146

SequenceSite65
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4532
type: SequenceSite
position status: EQUAL
sequence position: 1

Phosphate bond hydrolysis by NUDT proteins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction697
evidence: Evidence1030
xref: RelationshipXref984
xref: UnificationXref7087
xref: UnificationXref7086
pathway order: PathwayStep1009
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite66
type: SequenceSite
position status: EQUAL
sequence position: 424

SequenceSite4531
type: SequenceSite
position status: EQUAL
sequence position: 174

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 464

SequenceSite4517
type: SequenceSite
position status: EQUAL
sequence position: 577

SequenceSite4518
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4519
type: SequenceSite
position status: EQUAL
sequence position: 684

SequenceSite4513
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite69
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4514
type: SequenceSite
position status: EQUAL
sequence position: 1

Endosomal/Vacuolar pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1454
evidence: Evidence2311
xref: UnificationXref14688
xref: RelationshipXref1783
xref: UnificationXref14687
pathway order: PathwayStep2271
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4515
type: SequenceSite
position status: EQUAL
sequence position: 431

SequenceSite4516
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite76
type: SequenceSite
position status: EQUAL
sequence position: 261

SequenceSite4521
type: SequenceSite
position status: EQUAL
sequence position: 782

SequenceSite77
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4520
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite78
type: SequenceSite
position status: EQUAL
sequence position: 399

SequenceSite4523
type: SequenceSite
position status: EQUAL
sequence position: 1443

SequenceSite79
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4522
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite72
type: SequenceSite
position status: EQUAL
sequence position: 275

SequenceSite73
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite74
type: SequenceSite
position status: EQUAL
sequence position: 419

SequenceSite75
type: SequenceSite
position status: EQUAL
sequence position: 257

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

SequenceSite70
type: SequenceSite
position status: EQUAL
sequence position: 464

SequenceSite71
type: SequenceSite
position status: EQUAL
sequence position: 271

http://identifiers.org/pubmed/20127491
type: PublicationXref
id: 20127491
author: Owsianik, Grzegorz
author: Nilius, Bernd
db: Pubmed
title: Transient receptor potential channelopathies
source: Pflugers Arch. 460:437-50
year: 2010

SequenceSite4508
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4509
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite4506
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4507
type: SequenceSite
position status: EQUAL
sequence position: 1227

SequenceSite4504
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4505
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite4502
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4503
type: SequenceSite
position status: EQUAL
sequence position: 282

SequenceSite89
type: SequenceSite
position status: EQUAL
sequence position: 207

SequenceSite4512
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4511
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite87
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4510
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite88
type: SequenceSite
position status: EQUAL
sequence position: 347

SequenceSite85
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite86
type: SequenceSite
position status: EQUAL
sequence position: 193

SequenceSite83
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite84
type: SequenceSite
position status: EQUAL
sequence position: 464

SequenceSite81
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite82
type: SequenceSite
position status: EQUAL
sequence position: 424

http://identifiers.org/pubmed/9297626
type: PublicationXref
id: 9297626
author: Joneson, T
author: Bar-Sagi, Dafna
db: Pubmed
title: Ras effectors and their role in mitogenesis and oncogenesis
source: J Mol Med 75:587-93
year: 1997

SequenceSite80
type: SequenceSite
position status: EQUAL
sequence position: 427

SASP
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233050
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: DDB0233050
name: ADF
name: Surface associated sulphydryl protein
xref: UnificationXref6951
feature: FragmentFeature1226
cellular location: GO_0005829
comment: Reactome DB_ID: 5580815
display name: TXN

SASP
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233050
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Thioredoxin, oxidized
name: ATL-derived factor
name: 2xHC-TXN
name: DDB0233050
name: Surface associated sulphydryl protein
xref: UnificationXref6952
feature: ModificationFeature200
feature: FragmentFeature1227
feature: ModificationFeature199
cellular location: GO_0005829
comment: Reactome DB_ID: 5580814
display name: ADF

SASP
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233050
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: DDB0233050
name: ADF
name: Surface associated sulphydryl protein
xref: UnificationXref6957
feature: FragmentFeature1228
cellular location: GO_0005654
comment: Reactome DB_ID: 5582264
display name: TXN

SASP
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233050
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: DDB0233050
name: Surface associated sulphydryl protein
xref: UnificationXref6974
feature: FragmentFeature1229
feature: ModificationFeature201
feature: ModificationFeature202
cellular location: GO_0005654
comment: Reactome DB_ID: 5582268
display name: ADF

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238223
data source: Provenance1
name: DDB0238223
name: ribonucleotide reductase M2B (TP53 inducible)
xref: UnificationXref6975
feature: FragmentFeature1230
cellular location: GO_0005654
comment: Reactome DB_ID: 5582271
display name: RRM2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230075
data source: Provenance1
name: DDB0230075
name: Ribonucleoside-diphosphate reductase M1 chain (EC 1.17.4.1) (Ribonucleotide reductase large chain)
name: Ribonucleoside-diphosphate reductase M1 chain
name: ribonucleotide reductase M1 polypeptide
name: Ribonucleotide reductase large chain
xref: UnificationXref6979
feature: FragmentFeature1231
cellular location: GO_0005654
comment: Reactome DB_ID: 5582269
display name: RRM1

glutathione reductase
type: Protein
entity reference: UniProt:DDB0231410
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GSR isoform 2
name: GSR-2
name: GRase
name: DDB0231410
name: GSHR_HUMAN
name: Glutathione reductase, mitochondrial precursor
xref: UnificationXref6993
feature: FragmentFeature1232
cellular location: GO_0005829
comment: Reactome DB_ID: 5579813
display name: GR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216771
data source: Provenance1
name: Thioltransferase
name: Glutaredoxin
name: 2xHC-GLRX
name: DDB0216771
name: glutaredoxin (thioltransferase), oxidized
xref: UnificationXref6931
feature: ModificationFeature197
feature: FragmentFeature1223
feature: ModificationFeature198
cellular location: GO_0005829
comment: Reactome DB_ID: 5582242
display name: TTase

Ribonucleotide reductase small chain
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238223
data source: Provenance1
name: Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain)
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: DDB0238223
name: ribonucleotide reductase M2 polypeptide
xref: UnificationXref6943
feature: FragmentFeature1225
cellular location: GO_0005829
comment: Reactome DB_ID: 5582251
display name: RRM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230075
data source: Provenance1
name: DDB0230075
name: Ribonucleoside-diphosphate reductase M1 chain (EC 1.17.4.1) (Ribonucleotide reductase large chain)
name: Ribonucleoside-diphosphate reductase M1 chain
name: ribonucleotide reductase M1 polypeptide
name: Ribonucleotide reductase large chain
xref: UnificationXref6937
feature: FragmentFeature1224
cellular location: GO_0005829
comment: Reactome DB_ID: 5582246
display name: RRM1

CMPK1 Adenylate Kinases
type: Protein
data source: Provenance1
member physical entity: DDB0191367
xref: UnificationXref6896
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5580710

DDB0191367
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191367
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Deoxycytidylate kinase
name: UMP-CMP kinase
name: Cytidine monophosphate kinase
name: Cytidylate kinase
xref: UnificationXref6895
feature: FragmentFeature1218
cellular location: GO_0005829
comment: Reactome DB_ID: 5580709
display name: CMPK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230096
data source: Provenance1
name: Adenylate kinase isoenzyme 2, mitochondrial
name: adenylate kinase 2
name: DDB0230096
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase)
xref: UnificationXref6864
feature: FragmentFeature1216
cellular location: GO_0005758
comment: Reactome DB_ID: 5582107
display name: AK2

UniProt:DDB0304381
type: ProteinReference
xref: UnificationXref2034
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230100
data source: Provenance1
name: DDB0230100
name: Guanylate kinase (EC 2.7.4.8) (GMP kinase)
name: GMP kinase
name: guanylate kinase 1
xref: UnificationXref6875
feature: FragmentFeature1217
cellular location: GO_0005829
comment: Reactome DB_ID: 5580862
display name: GUK1

CTP synthase 2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230162
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230162
xref: UnificationXref6923
feature: FragmentFeature1221
cellular location: GO_0005829
comment: Reactome DB_ID: 5587833
display name: CTPS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216771
data source: Provenance1
name: TTase
name: Thioltransferase
name: Glutaredoxin
name: DDB0216771
xref: UnificationXref6928
feature: FragmentFeature1222
cellular location: GO_0005829
comment: Reactome DB_ID: 5582238
display name: GLRX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230101
data source: Provenance1
name: dTMP kinase
name: deoxythymidylate kinase (thymidylate kinase)
name: DDB0230101
name: Thymidylate kinase
xref: UnificationXref6912
feature: FragmentFeature1219
cellular location: GO_0005829
comment: Reactome DB_ID: 5580805
display name: DTYMK

UTP--ammonia ligase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230162
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230162
name: CTP synthase
name: CTP synthetase
xref: UnificationXref6919
feature: FragmentFeature1220
cellular location: GO_0005829
comment: Reactome DB_ID: 5580819
display name: CTPS1

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

DDB0185221
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185221
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: N-carbamoyl-beta-alanine amidohydrolase
name: BUP-1
name: Beta-alanine synthase
name: Beta-ureidopropionase
xref: UnificationXref6837
feature: FragmentFeature1215
cellular location: GO_0005829
comment: Reactome DB_ID: 5580767
display name: UPB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191172
data source: Provenance1
name: Dihydropyrimidinase
name: Hydantoinase
name: DDB0191172
name: DPYS
name: DHPase
xref: UnificationXref6829
feature: FragmentFeature1214
cellular location: GO_0005829
comment: Reactome DB_ID: 5580760
display name: DHP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230185
data source: Provenance1
name: DDB0230185
name: branched chain keto acid dehydrogenase E1, beta polypeptide
xref: UnificationXref7260
feature: FragmentFeature1251
cellular location: GO_0005759
comment: Reactome DB_ID: 5579304
display name: BCKDHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230054
data source: Provenance1
name: DDB0230054
xref: UnificationXref7192
feature: FragmentFeature1247
cellular location: GO_0005829
comment: Reactome DB_ID: 5588600
display name: PSPH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230183
data source: Provenance1
name: DDB0230183
name: PXLP-BCAT1
name: Branched-chain amino acid aminotransferase, cytosolic
xref: UnificationXref7221
feature: ModificationFeature206
feature: FragmentFeature1248
cellular location: GO_0005829
comment: Reactome DB_ID: 5579326
display name: BCAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230183
data source: Provenance1
name: DDB0230183
name: PXLP-BCAT2
name: branched-chain amino acid aminotransferase, mitochondrial, apoenzyme
xref: UnificationXref7241
feature: FragmentFeature1249
feature: ModificationFeature207
cellular location: GO_0005759
comment: Reactome DB_ID: 5579332
display name: BCAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230195
data source: Provenance1
name: DDB0230195
name: dihydrolipoamide branched chain transacylase E2
name: Lipo-DBT
xref: UnificationXref7258
feature: FragmentFeature1250
feature: ModificationFeature208
cellular location: GO_0005759
comment: Reactome DB_ID: 5579316
display name: DBT

http://identifiers.org/pubmed/11447121
type: PublicationXref
id: 11447121
author: Morimoto, R I
author: Eriksson, J E
author: MacKintosh, C
author: Mikhailov, A
author: Hietakangas, V
author: Kallio, M
author: Sistonen, L
author: Morrice, N
author: Rantanen, J O
author: Hellman, J
author: Meinander, A
author: Holmberg, C I
db: Pubmed
title: Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
source: EMBO J. 20:3800-10
year: 2001

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201634
data source: Provenance1
name: Glutaminase, kidney isoform, mitochondrial precursor
name: glutaminase
name: DDB0201634
xref: UnificationXref7168
feature: FragmentFeature1244
cellular location: GO_0005759
comment: Reactome DB_ID: 5579235
display name: GLS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231438
data source: Provenance1
name: DDB0231438
name: Glutamate dehydrogenase 1, mitochondrial precursor
xref: UnificationXref7151
feature: FragmentFeature1243
cellular location: GO_0005759
comment: Reactome DB_ID: 5579203
display name: GLUD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230053
data source: Provenance1
name: DDB0230053
xref: UnificationXref7187
feature: FragmentFeature1246
cellular location: GO_0005829
comment: Reactome DB_ID: 5588607
display name: PSAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201634
data source: Provenance1
name: Glutaminase, liver isoform, mitochondrial precursor
name: DDB0201634
name: glutaminase 2
xref: UnificationXref7170
feature: FragmentFeature1245
cellular location: GO_0005759
comment: Reactome DB_ID: 5579237
display name: GLS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230140
data source: Provenance1
name: Glutamine- dependent asparagine synthetase
name: TS11 cell cycle control protein
name: DDB0230140
name: Asparagine synthetase (glutamine-hydrolyzing)
xref: UnificationXref7142
feature: FragmentFeature1242
cellular location: GO_0005829
comment: Reactome DB_ID: 5579225
display name: ASNS

UniProt:DDB0304364
type: ProteinReference
xref: UnificationXref3587
organism: http://identifiers.org/taxonomy/44689

DDB0232206
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232206
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: pyrroline-5-carboxylate reductase 1
name: P5C reductase
xref: UnificationXref7131
feature: FragmentFeature1240
cellular location: GO_0005759
comment: Reactome DB_ID: 5579265
display name: PYCR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232207
data source: Provenance1
name: DDB0232207
name: pyrroline-5-carboxylate reductase 1
name: P5C reductase
xref: UnificationXref7133
feature: FragmentFeature1241
cellular location: GO_0005759
comment: Reactome DB_ID: 5579269
display name: PYCR1

DDB0231478
type: Protein
entity reference: UniProt:DDB0231478
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ornithine-oxo-acid aminotransferase
name: PXLP-OAT(26-439)
name: ornithine aminotransferase, mitochondrial
xref: UnificationXref7118
feature: FragmentFeature1239
feature: ModificationFeature205
cellular location: GO_0005759
comment: Reactome DB_ID: 5579258
display name: OAT

Homologues of PYCR1
type: Protein
data source: Provenance1
member physical entity: DDB0232206
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7134
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5579270

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232139
data source: Provenance1
name: Glutamic--pyruvic transaminase
name: DDB0232139
name: PXLP-GPT
name: glutamic-pyruvic transaminase
name: Alanine aminotransferase
name: glutamic-alanine transaminase
xref: UnificationXref7093
feature: ModificationFeature203
feature: FragmentFeature1237
cellular location: GO_0005829
comment: Reactome DB_ID: 5579178
display name: GPT

http://identifiers.org/pubmed/9199292
type: PublicationXref
id: 9199292
author: Dynlacht, BD
author: Sánchez, I
author: Woo, MS
db: Pubmed
title: p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
source: Mol Cell Biol 17:3566-79
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232139
data source: Provenance1
name: DDB0232139
name: Alanine aminotransferase 2 isoform 1
xref: UnificationXref7101
feature: ModificationFeature204
feature: FragmentFeature1238
cellular location: GO_0005759
comment: Reactome DB_ID: 5587838
display name: GPT2-1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204862
data source: Provenance1
name: Nudix motif 5
name: ADP-sugar pyrophosphatase
name: DDB0204862
xref: UnificationXref7082
feature: FragmentFeature1236
cellular location: GO_0005829
comment: Reactome DB_ID: 5591046
display name: NUDT5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238062
data source: Provenance1
name: DDB0238062
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref7061
feature: FragmentFeature1235
cellular location: GO_0005829
comment: Reactome DB_ID: 5591228
display name: ITPA

Nucleoside diphosphate kinase, mitochondrial
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214817
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0214817
name: nm23-H4
name: non-metastatic cells 4, protein expressed in
name: NDP kinase, mitochondrial
xref: UnificationXref7049
feature: FragmentFeature1234
cellular location: GO_0005743
comment: Reactome DB_ID: 5587825
display name: NME4

non-metastatic cells 1, protein (NM23A) expressed in
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214817
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tumor metastatic process-associated protein
name: NDK A
name: Nucleoside diphosphate kinase A
name: nm23-H1
name: Metastasis inhibition factor nm23
name: NDP kinase A
name: DDB0214817
xref: UnificationXref7015
feature: FragmentFeature1233
cellular location: GO_0005829
comment: Reactome DB_ID: 5587769
display name: NME1

Fibroblast Growth Factor Receptor (FGFR) signaling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction108
pathway component: BiochemicalReaction107
pathway component: REACT 245806.1
pathway component: BiochemicalReaction109
evidence: Evidence215
xref: UnificationXref1758
xref: UnificationXref1759
xref: RelationshipXref119
pathway order: PathwayStep194
pathway order: PathwayStep195
pathway order: PathwayStep196
pathway order: PathwayStep197
display name: Signaling by FGFR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234109
data source: Provenance1
name: Mitochondrial 2-oxodicarboxylate carrier
name: DDB0234109
xref: UnificationXref7420
feature: FragmentFeature1269
cellular location: GO_0005743
comment: Reactome DB_ID: 5585748
display name: SLC25A21

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168619
data source: Provenance1
name: DDB0168619
name: L-kynurenine/alpha-aminoadipate aminotransferase
name: PXLP-AADAT
xref: UnificationXref7410
feature: ModificationFeature210
feature: FragmentFeature1268
cellular location: GO_0005759
comment: Reactome DB_ID: 5579460
display name: AADAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234151
data source: Provenance1
name: glutaryl-CoA dehydrogenase
name: Glutaryl-CoA dehydrogenase, mitochondrial
name: DDB0234151
xref: UnificationXref7431
feature: FragmentFeature1270
cellular location: GO_0005759
comment: Reactome DB_ID: 5579580
display name: GCDH

Urocanase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234152
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: urocanate hydratase
name: DDB0234152
name: Imidazolonepropionate hydrolase
xref: UnificationXref7362
feature: FragmentFeature1262
cellular location: GO_0005829
comment: Reactome DB_ID: 5579418
display name: UROC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266532
data source: Provenance1
name: imidazolonepropionase (probable)
name: DDB0266532
xref: UnificationXref7370
feature: FragmentFeature1263
cellular location: GO_0005829
comment: Reactome DB_ID: 5579425
display name: AMDHD1

UniProt:DDB0231393
type: ProteinReference
xref: UnificationXref4473
organism: http://identifiers.org/taxonomy/44689

LCHC1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267047
data source: Provenance1
name: Glutamate formiminotransferase
name: DDB0267047
name: Formimidoyltetrahydrofolate cyclodeaminase
name: Formimidoyltransferase-cyclodeaminase
name: Formiminotransferase- cyclodeaminase
name: Note: the coordinates are copied over from Homo sapiens.
name: Formiminotetrahydrofolate cyclodeaminase
name: FTCD_HUMAN
name: formiminotransferase-cyclodeaminase apoenzyme monomer
name: Glutamate formyltransferase
name: Glutamate formimidoyltransferase
xref: UnificationXref7377
feature: FragmentFeature1264
cellular location: GO_0005829
comment: Reactome DB_ID: 5579431
display name: FTCD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238270
data source: Provenance1
name: LKR/SDH
name: DDB0238270
name: lysine-ketoglutarate reductase /saccharopine dehydrogenase monomer
xref: UnificationXref7387
feature: FragmentFeature1265
cellular location: GO_0005759
comment: Reactome DB_ID: 5579438
display name: AASS

DDB0231504
type: Protein
entity reference: UniProt:DDB0231504
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Alpha-aminoadipic semialdehyde dehydrogenase
name: antiquitin
xref: UnificationXref7400
feature: FragmentFeature1266
cellular location: GO_0005759
comment: Reactome DB_ID: 5579447
display name: ALDH7A1

Homologues of PXLP-AADAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7411
cellular location: GO_0005759
comment: Reactome DB_ID: 5579461
comment: Converted from EntitySet in Reactome

UniProt:DDB0231397
type: ProteinReference
xref: UnificationXref6389
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187583
data source: Provenance1
name: DDB0187583
name: L-kynurenine/alpha-aminoadipate aminotransferase
name: PXLP-AADAT
xref: UnificationXref7408
feature: ModificationFeature209
feature: FragmentFeature1267
cellular location: GO_0005759
comment: Reactome DB_ID: 5579455
display name: AADAT

http://identifiers.org/pubmed/9469823
type: PublicationXref
id: 9469823
author: Watanabe, H
author: Gu, L
author: Hong, Y
author: Li, G M
author: McCulloch, S
db: Pubmed
title: ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
source: Nucleic Acids Res. 26:1173-8
year: 1998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231727
data source: Provenance1
name: DDB0231727
name: Histidase
name: Histidine ammonia-lyase
xref: UnificationXref7355
feature: FragmentFeature1261
cellular location: GO_0005829
comment: Reactome DB_ID: 5579412
display name: HAL

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231483
data source: Provenance1
name: methylmalonate semialdehyde dehydrogenase, monomer
name: ALDH6A1
name: Methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) (MMSDH)
name: DDB0231483
xref: UnificationXref7343
feature: FragmentFeature1260
cellular location: GO_0005759
comment: Reactome DB_ID: 5579406
display name: MMSDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216217
data source: Provenance1
name: 3-hydroxyisobutyrate dehydrogenase, monomer
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor
name: D3HI_HUMAN
name: DDB0216217
xref: UnificationXref7336
feature: FragmentFeature1259
cellular location: GO_0005759
comment: Reactome DB_ID: 5579399
display name: HIBADH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233831
data source: Provenance1
name: 3-hydroxyisobutyryl-coenzyme A hydrolase
name: DDB0233831
xref: UnificationXref7329
feature: FragmentFeature1258
cellular location: GO_0005759
comment: Reactome DB_ID: 5579393
display name: HIBCH

UniProt:DDB0231390
type: ProteinReference
xref: UnificationXref2990
organism: http://identifiers.org/taxonomy/44689

8-oxoguanine [ChEBI:29116]
type: SmallMoleculeReference
name: 8-oxoguanine
xref: UnificationXref10602

UniProt:DDB0231383
type: ProteinReference
xref: UnificationXref6381
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230190
data source: Provenance1
name: branched chain keto acid dehydrogenase E1, alpha polypeptide
name: DDB0230190
xref: UnificationXref7262
feature: FragmentFeature1252
cellular location: GO_0005759
comment: Reactome DB_ID: 5579300
display name: BCKDHA

IVD_HUMAN
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230189
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230189
name: isovaleryl-CoA dehydrogenase, apoenzyme
name: Isovaleryl-CoA dehydrogenase, mitochondrial precursor
xref: UnificationXref7271
feature: FragmentFeature1253
cellular location: GO_0005759
comment: Reactome DB_ID: 5579339
display name: IVD

UniProt:DDB0231387
type: ProteinReference
xref: UnificationXref939
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168688
data source: Provenance1
name: HSD17B10
name: 2-methyl-3-hydroxybutyryl-CoA dehydrogenase
name: 3-hydroxyacyl-CoA dehydrogenase type II
name: Endoplasmic reticulum-associated amyloid beta-peptide binding protein
name: DDB0168688
name: endoplasmic reticulum-associated amyloid beta-peptide binding protein
xref: UnificationXref7306
feature: FragmentFeature1256
cellular location: GO_0005759
comment: Reactome DB_ID: 5579372
display name: HADH2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237710
data source: Provenance1
name: ARC42
name: acyl-CoA dehydrogenase family member 8
name: Acyl-CoA dehydrogenase family member 8, mitochondrial precursor
name: Activator- recruited cofactor 42 kDa component
name: isobutyryl-CoA dehydrogenase
name: DDB0237710
xref: UnificationXref7318
feature: FragmentFeature1257
cellular location: GO_0005759
comment: Reactome DB_ID: 5579386
display name: ACAD8

UniProt:DDB0231385
type: ProteinReference
xref: UnificationXref6373
organism: http://identifiers.org/taxonomy/44689

methylglutaconyl-CoA hydratase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233850
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0233850
name: AU RNA binding protein
xref: UnificationXref7287
feature: FragmentFeature1254
cellular location: GO_0005759
comment: Reactome DB_ID: 5579358
display name: AUH

2-MEBCAD
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237707
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: acyl-CoA dehydrogenase, short/branched chain specific
name: ACADSB
name: DDB0237707
name: ACADSB(52-432)
name: Acyl-CoA dehydrogenase, short/branched chain specific, mitochondrial precursor
name: 2-methylbutyryl-CoA dehydrogenase
name: 2-methyl branched chain acyl-CoA dehydrogenase
name: 2-methylbutyryl-coenzyme A dehydrogenase
name: Acyl-CoA dehydrogenase, short/branched chain specific, mitochondrial precursor (EC 1.3.99.-) (SBCAD) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)
xref: UnificationXref7295
feature: FragmentFeature1255
cellular location: GO_0005759
comment: Reactome DB_ID: 5579365
display name: SBCAD

CDO in myogenesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction28
evidence: Evidence56
xref: UnificationXref362
xref: UnificationXref363
xref: RelationshipXref31
pathway order: PathwayStep51
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231374
type: ProteinReference
xref: UnificationXref7685
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231373
type: ProteinReference
xref: UnificationXref12654
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231376
type: ProteinReference
xref: UnificationXref4659
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231375
type: ProteinReference
xref: UnificationXref12652
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231370
type: ProteinReference
xref: UnificationXref3354
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231372
type: ProteinReference
xref: UnificationXref6340
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, Jung-Ja P
author: Wang, M
author: Paschke, R
author: Fu, Zhuji
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref12060

DDB0167252
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0167252
data source: Provenance1
xref: UnificationXref7505
cellular location: GO_0005743
comment: Reactome DB_ID: 5579278

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231609
data source: Provenance1
name: Fumarylacetoacetate hydrolase
name: Beta-diketonase
name: DDB0231609
name: Fumarylacetoacetase
name: fumarylacetoacetate hydrolase
xref: UnificationXref7498
feature: FragmentFeature1278
cellular location: GO_0005829
comment: Reactome DB_ID: 5579643
display name: FAH

UniProt:DDB0231365
type: ProteinReference
xref: UnificationXref3349
organism: http://identifiers.org/taxonomy/44689

homogentisate 1,2-dioxygenase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191461
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Homogentisate 1,2-dioxygenase
name: Homogentisicase
name: HGD_HUMAN
name: DDB0191461
name: Homogentisic acid oxidase
name: Homogentisate oxygenase
name: homogentisic acid oxidase apoenzyme monomer
xref: UnificationXref7482
feature: FragmentFeature1276
cellular location: GO_0005829
comment: Reactome DB_ID: 5579629
display name: HGD

UniProt:DDB0231364
type: ProteinReference
xref: UnificationXref13224
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231608
data source: Provenance1
name: Maleylacetoacetate isomerase
name: MAAI_HUMAN
name: maleylacetoacetic acid isomerase apoenzyme monomer
name: GSTZ1
name: glutathione S-transferase zeta 1
name: aleylacetoacetate isomerase
name: DDB0231608
name: Glutathione S- transferase zeta 1) (GSTZ1-1
xref: UnificationXref7490
feature: FragmentFeature1277
cellular location: GO_0005829
comment: Reactome DB_ID: 5579636
display name: MAAI

UniProt:DDB0231363
type: ProteinReference
xref: UnificationXref7521
organism: http://identifiers.org/taxonomy/44689

4-hydroxyphenylpyruvate dioxygenase
type: Protein
entity reference: UniProt:DDB0231603
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0231603
name: 4HPPD
name: HPPDase
xref: UnificationXref7469
feature: FragmentFeature1274
cellular location: GO_0005829
comment: Reactome DB_ID: 5579619
display name: HPD

UniProt:DDB0231362
type: ProteinReference
xref: UnificationXref3316
organism: http://identifiers.org/taxonomy/44689

4-hydroxyphenylpyruvate dioxygenase
type: Protein
entity reference: UniProt:DDB0231604
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0231604
name: 4HPPD
name: HPPDase
xref: UnificationXref7471
feature: FragmentFeature1275
cellular location: GO_0005829
comment: Reactome DB_ID: 5579621
display name: HPD

UniProt:DDB0231361
type: ProteinReference
xref: UnificationXref7540
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0304399
type: ProteinReference
xref: UnificationXref2379
organism: http://identifiers.org/taxonomy/44689

ATTY_HUMAN
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230996
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tyrosine aminotransferase
name: L-tyrosine:2-oxoglutarate aminotransferase
name: DDB0230996
name: tyrosine aminotransferase
name: PXLP-TAT
xref: UnificationXref7459
feature: ModificationFeature211
feature: FragmentFeature1273
cellular location: GO_0005829
comment: Reactome DB_ID: 5579612
display name: TAT

UniProt:DDB0231360
type: ProteinReference
xref: UnificationXref7533
organism: http://identifiers.org/taxonomy/44689

Homologues of HPD
type: Protein
data source: Provenance1
member physical entity: 4-hydroxyphenylpyruvate dioxygenase
xref: UnificationXref7472
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5579622

4-alpha- hydroxy-tetrahydropterin dehydratase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305045
data source: Provenance1
name: PCD
name: Pterin carbinolamine dehydratase
name: PCBD1
name: Phenylalanine hydroxylase- stimulating protein
name: pterin-4-alpha-carbinolamine dehydratase
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0305045
name: Dimerization cofactor of HNF1
name: Pterin-4-alpha-carbinolamine dehydratase
name: DCoH
name: Dimerization cofactor of hepatocyte nuclear factor 1-alpha
name: 4-alpha-hydroxy-tetrahydropterin dehydratase
xref: UnificationXref7446
feature: FragmentFeature1271
cellular location: GO_0005829
comment: Reactome DB_ID: 5579604
display name: PHS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237752
data source: Provenance1
name: HDHPR
name: Dihydropteridine reductase
name: quinoid dihydropteridine reductase
name: DDB0237752
name: Quinoid dihydropteridine reductase
name: DHPR_HUMAN
name: dihydropteridine reductase monomer
xref: UnificationXref7451
feature: FragmentFeature1272
cellular location: GO_0005829
comment: Reactome DB_ID: 5579597
display name: QDPR

UniProt:DDB0231369
type: ProteinReference
xref: UnificationXref13265
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

UniProt:DDB0231366
type: ProteinReference
xref: UnificationXref13236
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231357
type: ProteinReference
xref: UnificationXref6365
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231358
type: ProteinReference
xref: UnificationXref6358
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231355
type: ProteinReference
xref: UnificationXref2532
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231359
type: ProteinReference
xref: UnificationXref7548
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231354
type: ProteinReference
xref: UnificationXref2521
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231349
type: ProteinReference
xref: UnificationXref7816
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/8128219
type: PublicationXref
id: 8128219
author: Tonks, N K
author: Flint, A J
author: Barford, D
db: Pubmed
title: Crystal structure of human protein tyrosine phosphatase 1B
source: Science 263:1397-404
year: 1994

Stoichiometry2800
type: Stoichiometry
physical entity: Complex1007
stoichiometric coefficient: 1.0

Stoichiometry2801
type: Stoichiometry
physical entity: Complex990
stoichiometric coefficient: 1.0

Stoichiometry2803
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

Stoichiometry2802
type: Stoichiometry
physical entity: PhysicalEntity189
stoichiometric coefficient: 1.0

Stoichiometry2805
type: Stoichiometry
physical entity: PhysicalEntity190
stoichiometric coefficient: 1.0

Stoichiometry2804
type: Stoichiometry
physical entity: Complex1013
stoichiometric coefficient: 1.0

Stoichiometry2807
type: Stoichiometry
physical entity: Complex1014
stoichiometric coefficient: 1.0

Stoichiometry2806
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

Stoichiometry2809
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 3.0

Stoichiometry2808
type: Stoichiometry
physical entity: Complex1012
stoichiometric coefficient: 1.0

UniProt:DDB0231339
type: ProteinReference
xref: UnificationXref1236
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231338
type: ProteinReference
xref: UnificationXref1179
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231333
type: ProteinReference
xref: UnificationXref12063
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231334
type: ProteinReference
xref: UnificationXref12253
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231332
type: ProteinReference
xref: UnificationXref12119
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231330
type: ProteinReference
xref: UnificationXref12343
organism: http://identifiers.org/taxonomy/44689

Linoleic acid (LA) metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction540
pathway component: BiochemicalReaction538
pathway component: BiochemicalReaction539
pathway component: BiochemicalReaction536
pathway component: BiochemicalReaction537
evidence: Evidence818
xref: UnificationXref5724
xref: RelationshipXref737
xref: UnificationXref5725
pathway order: PathwayStep794
pathway order: PathwayStep793
pathway order: PathwayStep796
pathway order: PathwayStep795
pathway order: PathwayStep797
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

UniProt:DDB0231327
type: ProteinReference
xref: UnificationXref12161
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231328
type: ProteinReference
xref: UnificationXref12163
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231322
type: ProteinReference
xref: UnificationXref12278
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231324
type: ProteinReference
xref: UnificationXref12243
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231325
type: ProteinReference
xref: UnificationXref12039
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231320
type: ProteinReference
xref: UnificationXref12270
organism: http://identifiers.org/taxonomy/44689

Recycling of bile acids and salts
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction433
evidence: Evidence684
xref: UnificationXref4880
xref: RelationshipXref594
xref: UnificationXref4879
pathway order: PathwayStep656
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2830
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

Stoichiometry2834
type: Stoichiometry
physical entity: PhysicalEntity194
stoichiometric coefficient: 1.0

Stoichiometry2833
type: Stoichiometry
physical entity: Complex871
stoichiometric coefficient: 1.0

Stoichiometry2832
type: Stoichiometry
physical entity: Complex997
stoichiometric coefficient: 1.0

Stoichiometry2831
type: Stoichiometry
physical entity: PhysicalEntity193
stoichiometric coefficient: 1.0

UniProt:DDB0231314
type: ProteinReference
xref: UnificationXref12351
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231313
type: ProteinReference
xref: UnificationXref12108
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231311
type: ProteinReference
xref: UnificationXref12261
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231318
type: ProteinReference
xref: UnificationXref12081
organism: http://identifiers.org/taxonomy/44689

RNA Pol II CTD phosphorylation and interaction with CE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1153
pathway component: BiochemicalReaction1150
pathway component: BiochemicalReaction1152
pathway component: BiochemicalReaction1151
evidence: Evidence1768
xref: UnificationXref11231
xref: UnificationXref11230
pathway order: PathwayStep1733
pathway order: PathwayStep1732
pathway order: PathwayStep1731
pathway order: PathwayStep1734
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231317
type: ProteinReference
xref: UnificationXref12052
organism: http://identifiers.org/taxonomy/44689

Adenosine kinase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230174
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230174
name: ADK
name: Adenosine 5'-phosphotransferase
xref: UnificationXref6627
feature: FragmentFeature1194
cellular location: GO_0005829
comment: Reactome DB_ID: 5581961
display name: AK

DDB0230171
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230171
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenosine aminohydrolase
name: Adenosine deaminase
xref: UnificationXref6622
feature: FragmentFeature1193
cellular location: GO_0005829
comment: Reactome DB_ID: 5581161
display name: ADA

IMP--aspartate ligase 2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201565
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0201565
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
name: AdSS 2
xref: UnificationXref6591
feature: FragmentFeature1192
cellular location: GO_0005829
comment: Reactome DB_ID: 5582224
display name: ADSS

ASASE
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230094
data source: Provenance1
name: Adenylosuccinase
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230094
name: Adenylosuccinate lyase
name: ADSL
xref: UnificationXref6557
feature: FragmentFeature1187
cellular location: GO_0005829
comment: Reactome DB_ID: 5580891
display name: ASL

Stoichiometry2837
type: Stoichiometry
physical entity: Protein2259
stoichiometric coefficient: 1.0

FGAM synthase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230086
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: FGAMS
name: Formylglycinamide ribotide synthetase
name: Phosphoribosylformylglycinamidine synthase
name: DDB0230086
name: Formylglycinamide ribotide amidotransferase
name: FGARAT
xref: UnificationXref6539
feature: FragmentFeature1186
cellular location: GO_0005829
comment: Reactome DB_ID: 5580904
display name: PFAS

Stoichiometry2838
type: Stoichiometry
physical entity: PhysicalEntity195
stoichiometric coefficient: 1.0

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230084
data source: Provenance1
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: DDB0230084
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: Phosphoribosyl-aminoimidazole synthetase
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref6524
feature: FragmentFeature1185
cellular location: GO_0005829
comment: Reactome DB_ID: 5580898
display name: GART

Stoichiometry2835
type: Stoichiometry
physical entity: Complex1021
stoichiometric coefficient: 1.0

Stoichiometry2836
type: Stoichiometry
physical entity: Protein2469
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201565
data source: Provenance1
name: IMP--aspartate ligase 1
name: DDB0201565
name: AMPSase 1
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: adenylosuccinate synthetase like 1
xref: UnificationXref6588
feature: FragmentFeature1191
cellular location: GO_0005829
comment: Reactome DB_ID: 5582221
display name: ADSSL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215334
data source: Provenance1
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: GMP synthetase
name: DDB0215334
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref6581
feature: FragmentFeature1190
cellular location: GO_0005829
comment: Reactome DB_ID: 5580868
display name: GMPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230098
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: DDB0230098
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref6575
feature: FragmentFeature1189
cellular location: GO_0005829
comment: Reactome DB_ID: 5580874
display name: IMPDH1

Stoichiometry2839
type: Stoichiometry
physical entity: Protein2260
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230095
data source: Provenance1
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: DDB0230095
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref6565
feature: FragmentFeature1188
cellular location: GO_0005829
comment: Reactome DB_ID: 5580882
display name: ATIC

Stoichiometry2841
type: Stoichiometry
physical entity: Complex1002
stoichiometric coefficient: 1.0

Stoichiometry2840
type: Stoichiometry
physical entity: Complex1023
stoichiometric coefficient: 1.0

Stoichiometry2843
type: Stoichiometry
physical entity: Complex1001
stoichiometric coefficient: 1.0

Stoichiometry2842
type: Stoichiometry
physical entity: Complex1024
stoichiometric coefficient: 1.0

Stoichiometry2845
type: Stoichiometry
physical entity: PhysicalEntity196
stoichiometric coefficient: 1.0

Stoichiometry2844
type: Stoichiometry
physical entity: Protein2472
stoichiometric coefficient: 1.0

UniProt:DDB0231305
type: ProteinReference
xref: UnificationXref12182
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231306
type: ProteinReference
xref: UnificationXref12361
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231308
type: ProteinReference
xref: UnificationXref12043
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231309
type: ProteinReference
xref: UnificationXref12041
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2846
type: Stoichiometry
physical entity: Protein2474
stoichiometric coefficient: 1.0

Stoichiometry2847
type: Stoichiometry
physical entity: Protein2475
stoichiometric coefficient: 1.0

Stoichiometry2848
type: Stoichiometry
physical entity: Protein2476
stoichiometric coefficient: 1.0

Stoichiometry2849
type: Stoichiometry
physical entity: Protein2477
stoichiometric coefficient: 1.0

Stoichiometry2812
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

XDH
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230176
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230176
name: Xanthine dehydrogenase
name: Xanthine oxidase
name: Xanthine dehydrogenase/oxidase
name: Xanthine oxidoreductase
name: XO
xref: UnificationXref6706
feature: FragmentFeature1204
cellular location: GO_0005829
comment: Reactome DB_ID: 5581168
display name: XD

Stoichiometry2811
type: Stoichiometry
physical entity: PhysicalEntity191
stoichiometric coefficient: 1.0

Stoichiometry2810
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

DDB0231100
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0231100
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydropyrimidine dehydrogenase (NADP+)
name: DHPDHase
name: Dihydrouracil dehydrogenase
name: Dihydrothymine dehydrogenase
xref: UnificationXref6821
feature: FragmentFeature1213
cellular location: GO_0005829
comment: Reactome DB_ID: 5580753
display name: DPYD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230205
data source: Provenance1
name: DDB0230205
name: Cytidine deaminase
name: Cytidine aminohydrolase
xref: UnificationXref6808
feature: FragmentFeature1212
cellular location: GO_0005829
comment: Reactome DB_ID: 5580786
display name: CDA

Stoichiometry2819
type: Stoichiometry
physical entity: Complex997
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191436
data source: Provenance1
name: Thymidine kinase, cytosolic
name: DDB0191436
name: Thymidine kinase, cytosolic (EC 2.7.1.21)
name: thymidine kinase 1, soluble
xref: UnificationXref6795
feature: FragmentFeature1211
cellular location: GO_0005829
comment: Reactome DB_ID: 5580796
display name: TK1

Uridine monophosphokinase 2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230208
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytidine monophosphokinase 2
name: Uridine-cytidine kinase 2
name: DDB0230208
xref: UnificationXref6784
feature: FragmentFeature1210
cellular location: GO_0005829
comment: Reactome DB_ID: 5582062
display name: UCK 2

Stoichiometry2817
type: Stoichiometry
physical entity: PhysicalEntity192
stoichiometric coefficient: 1.0

UCK 1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230208
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Uridine monophosphokinase 1
name: Cytidine monophosphokinase 1
name: Uridine-cytidine kinase 1
name: DDB0230208
xref: UnificationXref6780
feature: FragmentFeature1209
cellular location: GO_0005829
comment: Reactome DB_ID: 5580778
display name: UCK1

Stoichiometry2818
type: Stoichiometry
physical entity: Complex1017
stoichiometric coefficient: 1.0

DDB0230111
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230111
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: deoxyuridine triphosphatase isoform 2
name: dUTP pyrophosphatase
xref: UnificationXref6765
feature: FragmentFeature1208
cellular location: GO_0005654
comment: Reactome DB_ID: 5580826
display name: DUT-2

Stoichiometry2815
type: Stoichiometry
physical entity: Complex993
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/9548747
type: PublicationXref
id: 9548747
author: Hammond, PW
author: Cech, TR
db: Pubmed
title: Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation
source: Biochemistry 37:5162-72
year: 1998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214958
data source: Provenance1
name: Orotate phosphoribosyltransferase
name: OMPdecase
name: OPRtase
name: DDB0214958
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: Uridine 5'-monophosphate synthase
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref6752
feature: FragmentFeature1207
cellular location: GO_0005829
comment: Reactome DB_ID: 5580716
display name: UMPS

Stoichiometry2816
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201646
data source: Provenance1
name: Aspartate carbamoyltransferase
name: Dihydroorotase
name: DDB0201646
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref6731
feature: FragmentFeature1206
cellular location: GO_0005829
comment: Reactome DB_ID: 5580725
display name: CAD

Stoichiometry2813
type: Stoichiometry
physical entity: Complex1016
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185123
data source: Provenance1
name: DDB0185123
name: Catalase apoprotein (EC 1.11.1.6)
name: Catalase
name: CATA_HUMAN
xref: UnificationXref6718
feature: FragmentFeature1205
cellular location: GO_0005782
comment: Reactome DB_ID: 5581750
display name: CAT

Stoichiometry2814
type: Stoichiometry
physical entity: Protein2412
stoichiometric coefficient: 1.0

Stoichiometry2821
type: Stoichiometry
physical entity: Complex1015
stoichiometric coefficient: 1.0

Stoichiometry2820
type: Stoichiometry
physical entity: Complex1011
stoichiometric coefficient: 1.0

Stoichiometry2823
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

DAP12 interactions
type: Pathway
data source: Provenance1
pathway component: REACT 226583.2
evidence: Evidence2367
xref: UnificationXref14989
xref: UnificationXref14990
pathway order: PathwayStep2327
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2822
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 3.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230211
data source: Provenance1
name: GAH
name: Guanase
name: Guanine deaminase
name: p51-nedasin
name: Guanine aminohydrolase
name: DDB0230211
name: Guanine aminase
xref: UnificationXref6700
feature: FragmentFeature1203
cellular location: GO_0005829
comment: Reactome DB_ID: 5581185
display name: GDA

DDB0230202
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230202
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: cytosolic purine 5'-nucleotidase
name: high Km 5'-nucleotidase
name: Cytosolic purine 5'-nucleotidase
name: 5'-nucleotidase cytosolic II
xref: UnificationXref6692
feature: FragmentFeature1202
cellular location: GO_0005829
comment: Reactome DB_ID: 5581177
display name: NT5C2

Adenine phosphoribosyltransferase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230173
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230173
xref: UnificationXref6655
feature: FragmentFeature1199
cellular location: GO_0005829
comment: Reactome DB_ID: 5581136
display name: APRT

Stoichiometry2828
type: Stoichiometry
physical entity: Complex1014
stoichiometric coefficient: 1.0

Homologues of APRT
type: Protein
data source: Provenance1
member physical entity: Adenine phosphoribosyltransferase
xref: UnificationXref6658
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581141

Stoichiometry2829
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 3.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216388
data source: Provenance1
name: HGPRTase
name: Hypoxanthine-guanine phosphoribosyltransferase
name: DDB0216388
name: HGPRT
xref: UnificationXref6671
feature: FragmentFeature1201
cellular location: GO_0005829
comment: Reactome DB_ID: 5581150
display name: HPRT1

Adenine phosphoribosyltransferase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187721
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0187721
xref: UnificationXref6657
feature: FragmentFeature1200
cellular location: GO_0005829
comment: Reactome DB_ID: 5581140
display name: APRT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191089
data source: Provenance1
name: AMP deaminase isoform L
name: DDB0191089
name: AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)
name: AMP deaminase 2
xref: UnificationXref6634
feature: FragmentFeature1196
cellular location: GO_0005829
comment: Reactome DB_ID: 5581832
display name: AMPD2

Stoichiometry2824
type: Stoichiometry
physical entity: Complex1016
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191089
data source: Provenance1
name: AMP deaminase 1 (EC 3.5.4.6) (Myoadenylate deaminase) (AMP deaminase isoform M)
name: Myoadenylate deaminase
name: DDB0191089
name: AMP deaminase isoform M
name: myoadenylate deaminase
name: AMP deaminase 1
xref: UnificationXref6632
feature: FragmentFeature1195
cellular location: GO_0005829
comment: Reactome DB_ID: 5581830
display name: AMPD1

Stoichiometry2825
type: Stoichiometry
physical entity: Complex1017
stoichiometric coefficient: 1.0

DDB0230171
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230171
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenosine deaminase-like protein
xref: UnificationXref6647
feature: FragmentFeature1198
cellular location: GO_0005829
comment: Reactome DB_ID: 5590747
display name: ADAL

Stoichiometry2826
type: Stoichiometry
physical entity: Complex990
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191089
data source: Provenance1
name: DDB0191089
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: erythrocyte AMP deaminase
xref: UnificationXref6636
feature: FragmentFeature1197
cellular location: GO_0005829
comment: Reactome DB_ID: 5581834
display name: AMPD3

Stoichiometry2827
type: Stoichiometry
physical entity: Complex997
stoichiometric coefficient: 1.0

Stoichiometry2540
type: Stoichiometry
physical entity: Protein2341
stoichiometric coefficient: 1.0

Stoichiometry2544
type: Stoichiometry
physical entity: Protein2342
stoichiometric coefficient: 2.0

UnificationXref2750
type: UnificationXref
id: 5579706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579706

Stoichiometry2543
type: Stoichiometry
physical entity: SmallMolecule13
stoichiometric coefficient: 2.0

Stoichiometry2542
type: Stoichiometry
physical entity: Protein2341
stoichiometric coefficient: 1.0

Stoichiometry2541
type: Stoichiometry
physical entity: ferroheme
stoichiometric coefficient: 1.0

UnificationXref2753
type: UnificationXref
id: REACT_263269
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263269.1

Stoichiometry2548
type: Stoichiometry
physical entity: Protein103
stoichiometric coefficient: 2.0

UnificationXref2754
type: UnificationXref
id: 5584897
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584897

Stoichiometry2547
type: Stoichiometry
physical entity: Protein2349
stoichiometric coefficient: 1.0

UnificationXref2751
type: UnificationXref
id: 5579707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579707

Stoichiometry2546
type: Stoichiometry
physical entity: DDB0305274
stoichiometric coefficient: 2.0

UnificationXref2752
type: UnificationXref
id: 5579709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579709

Stoichiometry2545
type: Stoichiometry
physical entity: Protein2345
stoichiometric coefficient: 2.0

UnificationXref2758
type: UnificationXref
id: REACT_4214
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4214.2

UnificationXref2757
type: UnificationXref
id: 73578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73578

UnificationXref2756
type: UnificationXref
id: CHEBI:17797
db: ChEBI

Stoichiometry2549
type: Stoichiometry
physical entity: Complex958
stoichiometric coefficient: 1.0

UnificationXref2755
type: UnificationXref
id: REACT_250641
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250641.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304904
data source: Provenance1
name: ESCO1
name: N-acetyltransferase ESCO1
name: DDB0304904
name: Establishment of cohesion 1 homolog 1
xref: UnificationXref9292
feature: FragmentFeature1561
cellular location: GO_0005654
comment: Reactome DB_ID: 5591189
display name: EFO1

ESCO1/ESCO2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
name: ESCO1/2
xref: UnificationXref9294
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5591191
display name: ESCO

2xAcK-SMC3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219934
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0219934
xref: UnificationXref9287
feature: FragmentFeature1560
feature: ModificationFeature239
feature: ModificationFeature238
cellular location: GO_0005654
comment: Reactome DB_ID: 5591182
display name: Ac-SMC3

UnificationXref2759
type: UnificationXref
id: CHEBI:15721
db: ChEBI

SMC1 (BAA11495)
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219931
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (SB1.8/DXS423E protein) (Sb1.8)
name: Structural maintenance of chromosome 1-like 1 protein
name: DDB0219931
name: SB1.8/DXS423E protein
name: Sb1.8
name: SMC1alpha protein
xref: UnificationXref9281
feature: FragmentFeature1559
cellular location: GO_0005654
comment: Reactome DB_ID: 5580009
display name: SMC1A

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cdc25B
name: Dual specificity phosphatase Cdc25B
name: M-phase inducer phosphatase 2
name: M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
xref: UnificationXref9318
feature: FragmentFeature1565
cellular location: GO_0005829
comment: Reactome DB_ID: 5583318
display name: CDC25B

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cdc25B
name: Dual specificity phosphatase Cdc25B
name: M-phase inducer phosphatase 2
name: M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
xref: UnificationXref9317
feature: FragmentFeature1564
cellular location: GO_0005654
comment: Reactome DB_ID: 5583317
display name: CDC25B

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
name: Cdc25C
name: Dual specificity phosphatase Cdc25C
name: M-phase inducer phosphatase 3
xref: UnificationXref9314
feature: FragmentFeature1563
cellular location: GO_0005829
comment: Reactome DB_ID: 5583320
display name: CDC25C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304904
data source: Provenance1
name: DDB0304904
name: Establishment of cohesion 1 homolog 2
xref: UnificationXref9293
feature: FragmentFeature1562
cellular location: GO_0005654
comment: Reactome DB_ID: 5591190
display name: ESCO2

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cdc25A
xref: UnificationXref9321
feature: FragmentFeature1566
cellular location: GO_0005829
comment: Reactome DB_ID: 5583322
display name: CDC25A

Cdc25
type: Protein
data source: Provenance1
member physical entity: DDB0191424
xref: UnificationXref9322
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583323

Stoichiometry2531
type: Stoichiometry
physical entity: Protein2328
stoichiometric coefficient: 4.0

Stoichiometry2530
type: Stoichiometry
physical entity: SmallMolecule24
stoichiometric coefficient: 2.0

UnificationXref2760
type: UnificationXref
id: 29882
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29882

Stoichiometry2533
type: Stoichiometry
physical entity: Protein2334
stoichiometric coefficient: 1.0

UnificationXref2761
type: UnificationXref
id: REACT_5523
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5523.1

Stoichiometry2532
type: Stoichiometry
physical entity: gamma-L-Glutamyl-L-cysteinyl-glycine
stoichiometric coefficient: 2.0

UnificationXref2762
type: UnificationXref
id: DDB0231244
db: UniProt

Stoichiometry2535
type: Stoichiometry
physical entity: Complex950
stoichiometric coefficient: 2.0

UnificationXref2763
type: UnificationXref
id: 5579719
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579719

Stoichiometry2534
type: Stoichiometry
physical entity: SmallMolecule412
stoichiometric coefficient: 1.0

UnificationXref2764
type: UnificationXref
id: CHEBI:9532
db: ChEBI

Stoichiometry2537
type: Stoichiometry
physical entity: Protein2337
stoichiometric coefficient: 2.0

UnificationXref2765
type: UnificationXref
id: 29480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29480

Stoichiometry2536
type: Stoichiometry
physical entity: SmallMolecule386
stoichiometric coefficient: 2.0

UnificationXref2767
type: UnificationXref
id: 5579720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579720

Stoichiometry2538
type: Stoichiometry
physical entity: Complex952
stoichiometric coefficient: 6.0

UnificationXref2766
type: UnificationXref
id: REACT_4009
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4009.4

Stoichiometry2539
type: Stoichiometry
physical entity: ferriheme
stoichiometric coefficient: 1.0

UnificationXref2769
type: UnificationXref
id: REACT_245247
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245247.1

Cdc25
type: Protein
data source: Provenance1
member physical entity: DDB0191424
xref: UnificationXref9323
cellular location: GO_0005654
comment: Reactome DB_ID: 5583324
comment: Converted from EntitySet in Reactome

UnificationXref2768
type: UnificationXref
id: 5579722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579722

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

phospho-p-T210-PLK1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216332
data source: Provenance1
xref: UnificationXref9329
feature: ModificationFeature269
feature: FragmentFeature1568
cellular location: GO_0005654
comment: Reactome DB_ID: 5591637

phospho-p-T210-PLK1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216332
data source: Provenance1
xref: UnificationXref9328
feature: FragmentFeature1567
feature: ModificationFeature269
cellular location: GO_0005829
comment: Reactome DB_ID: 5591636

phospho-p-S198-CDC25C
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
xref: UnificationXref9337
feature: ModificationFeature271
feature: FragmentFeature1570
cellular location: GO_0005654
comment: Reactome DB_ID: 5582785

phospho-p-S53-WEE1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220004
data source: Provenance1
xref: UnificationXref9334
feature: ModificationFeature270
feature: FragmentFeature1569
cellular location: GO_0005654
comment: Reactome DB_ID: 5582796

phospho-p-PKMYT1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229384
data source: Provenance1
xref: UnificationXref9340
feature: ModificationFeature272
feature: FragmentFeature1571
cellular location: GO_0005654
comment: Reactome DB_ID: 5582907

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, Pietro
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

Homologues of p-PKMYT1
type: Protein
data source: Provenance1
member physical entity: phospho-p-PKMYT1
xref: UnificationXref9342
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5582910

DDB0266709
type: Protein
entity reference: UniProt:DDB0266709
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cdh1
xref: UnificationXref9353
feature: FragmentFeature1573
cellular location: GO_0005654
comment: Reactome DB_ID: 5583467
display name: FZR1

phospho-p-PKMYT1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216398
data source: Provenance1
xref: UnificationXref9341
feature: FragmentFeature1572
feature: ModificationFeature273
cellular location: GO_0005654
comment: Reactome DB_ID: 5582909

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234263
data source: Provenance1
name: Apc1/Tsg24
name: DDB0234263
xref: UnificationXref9354
feature: FragmentFeature1574
cellular location: GO_0005654
comment: Reactome DB_ID: 5583399
display name: ANAPC1

Stoichiometry2562
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

Stoichiometry2561
type: Stoichiometry
physical entity: Protein2359
stoichiometric coefficient: 3.0

Stoichiometry2560
type: Stoichiometry
physical entity: Protein2356
stoichiometric coefficient: 3.0

UnificationXref2775
type: UnificationXref
id: DDB0231283
db: UniProt

UnificationXref2776
type: UnificationXref
id: 5579726
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579726

Stoichiometry2569
type: Stoichiometry
physical entity: Protein2381
stoichiometric coefficient: 3.0

UnificationXref2773
type: UnificationXref
id: 29878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29878

Stoichiometry2568
type: Stoichiometry
physical entity: Complex961
stoichiometric coefficient: 1.0

UnificationXref2774
type: UnificationXref
id: REACT_2886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2886.2

Stoichiometry2567
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

UnificationXref2771
type: UnificationXref
id: REACT_261403
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261403.1

Stoichiometry2566
type: Stoichiometry
physical entity: Complex968
stoichiometric coefficient: 2.0

UnificationXref2772
type: UnificationXref
id: CHEBI:16897
db: ChEBI

Stoichiometry2565
type: Stoichiometry
physical entity: Protein2362
stoichiometric coefficient: 1.0

Stoichiometry2564
type: Stoichiometry
physical entity: Protein2361
stoichiometric coefficient: 1.0

UnificationXref2770
type: UnificationXref
id: 5583066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5583066

Stoichiometry2563
type: Stoichiometry
physical entity: Protein2360
stoichiometric coefficient: 1.0

UnificationXref2779
type: UnificationXref
id: 5583085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5583085

UnificationXref2778
type: UnificationXref
id: REACT_248404
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248404.1

UnificationXref2777
type: UnificationXref
id: 5579728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579728

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

Stoichiometry2551
type: Stoichiometry
physical entity: Protein2349
stoichiometric coefficient: 3.0

Stoichiometry2550
type: Stoichiometry
physical entity: DDB0305274
stoichiometric coefficient: 2.0

UnificationXref2784
type: UnificationXref
id: REACT_240552
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240552.1

Stoichiometry2557
type: Stoichiometry
physical entity: Protein2358
stoichiometric coefficient: 2.0

UnificationXref2785
type: UnificationXref
id: DDB0231225
db: UniProt

Stoichiometry2556
type: Stoichiometry
physical entity: Protein2357
stoichiometric coefficient: 2.0

UnificationXref2786
type: UnificationXref
id: 5579713
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579713

Stoichiometry2559
type: Stoichiometry
physical entity: Protein2355
stoichiometric coefficient: 2.0

UnificationXref2787
type: UnificationXref
id: 5579715
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579715

Stoichiometry2558
type: Stoichiometry
physical entity: Complex963
stoichiometric coefficient: 1.0

UnificationXref2780
type: UnificationXref
id: REACT_230080
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230080.1

Stoichiometry2553
type: Stoichiometry
physical entity: Protein2354
stoichiometric coefficient: 3.0

UnificationXref2781
type: UnificationXref
id: 5579729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579729

Stoichiometry2552
type: Stoichiometry
physical entity: Protein2350
stoichiometric coefficient: 3.0

UnificationXref2782
type: UnificationXref
id: REACT_230875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230875.1

Stoichiometry2555
type: Stoichiometry
physical entity: Protein2356
stoichiometric coefficient: 1.0

UnificationXref2783
type: UnificationXref
id: 5583083
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5583083

Stoichiometry2554
type: Stoichiometry
physical entity: Protein2355
stoichiometric coefficient: 2.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229294
data source: Provenance1
name: DDB0229294
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref9256
feature: FragmentFeature1550
cellular location: GO_0005829
comment: Reactome DB_ID: 5581417
display name: CDK4

phospho-p-T286-CCND1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
xref: UnificationXref9259
feature: FragmentFeature1552
feature: ModificationFeature268
cellular location: GO_0005829
comment: Reactome DB_ID: 5581414

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267010
data source: Provenance1
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: DDB0267010
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref9257
feature: FragmentFeature1551
cellular location: GO_0005829
comment: Reactome DB_ID: 5581418
display name: CDK4

UnificationXref2789
type: UnificationXref
id: 5583703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5583703

UnificationXref2788
type: UnificationXref
id: REACT_247522
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247522.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219934
data source: Provenance1
name: Structural maintenance of chromosomes protein 3
name: DDB0219934
xref: UnificationXref9279
feature: FragmentFeature1557
cellular location: GO_0005654
comment: Reactome DB_ID: 5588225
display name: SMC3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238657
data source: Provenance1
name: DDB0238657
name: SCC3 homolog 1
name: Cohesin subunit SA-1
name: STAG1
xref: UnificationXref9278
feature: FragmentFeature1556
cellular location: GO_0005654
comment: Reactome DB_ID: 5588220
display name: SA1

DDB0305113
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305113
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9280
feature: FragmentFeature1558
cellular location: GO_0005654
comment: Reactome DB_ID: 5588219
display name: RAD21

DDB0305112
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305112
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sister chromatid cohesion protein PDS5 homolog A
name: PDS5A
xref: UnificationXref9274
feature: FragmentFeature1553
cellular location: GO_0005654
comment: Reactome DB_ID: 5591177
display name: PDS5

PDS5A/PDS5B
type: Protein
data source: Provenance1
member physical entity: DDB0305112
name: PDS5A/B
xref: UnificationXref9276
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5591179
display name: PDS5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238657
data source: Provenance1
name: DDB0238657
name: Cohesin subunit SA-2
name: SCC3 homolog 2
name: STAG2
xref: UnificationXref9277
feature: FragmentFeature1555
cellular location: GO_0005654
comment: Reactome DB_ID: 5588221
display name: SA2

DDB0305112
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305112
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sister chromatid cohesion protein PDS5 homolog B
name: PDS5B
name: APRIN
xref: UnificationXref9275
feature: FragmentFeature1554
cellular location: GO_0005654
comment: Reactome DB_ID: 5591178
display name: AS3

Stoichiometry2500
type: Stoichiometry
physical entity: Complex935
stoichiometric coefficient: 1.0

UnificationXref2710
type: UnificationXref
id: REACT_5012
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5012.2

Stoichiometry2503
type: Stoichiometry
physical entity: Complex937
stoichiometric coefficient: 2.0

Stoichiometry2504
type: Stoichiometry
physical entity: Cu(I)
stoichiometric coefficient: 1.0

Stoichiometry2501
type: Stoichiometry
physical entity: Complex936
stoichiometric coefficient: 1.0

Stoichiometry2502
type: Stoichiometry
physical entity: Complex937
stoichiometric coefficient: 2.0

UnificationXref6879
type: UnificationXref
id: REACT_177996
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177996.3

UnificationXref6878
type: UnificationXref
id: 5582101
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582101

UnificationXref6877
type: UnificationXref
id: REACT_206055
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206055.2

UnificationXref2719
type: UnificationXref
id: 31467
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31467

UnificationXref6876
type: UnificationXref
id: 5580864
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580864

UnificationXref6875
type: UnificationXref
id: 5580862
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580862

UnificationXref6874
type: UnificationXref
id: DDB0230100
db: UniProt

UnificationXref6873
type: UnificationXref
id: 5580858
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580858

UnificationXref6872
type: UnificationXref
id: REACT_4501
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4501.2

UnificationXref6871
type: UnificationXref
id: 110092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110092

UnificationXref2713
type: UnificationXref
id: 5579060
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579060

Stoichiometry2508
type: Stoichiometry
physical entity: Copper
stoichiometric coefficient: 1.0

UnificationXref6870
type: UnificationXref
id: CHEBI:28862
db: ChEBI

UnificationXref2714
type: UnificationXref
id: 5579062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579062

Stoichiometry2507
type: Stoichiometry
physical entity: Complex939
stoichiometric coefficient: 2.0

UnificationXref2711
type: UnificationXref
id: DDB0231575
db: UniProt

Stoichiometry2506
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

UnificationXref2712
type: UnificationXref
id: 5579059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579059

Stoichiometry2505
type: Stoichiometry
physical entity: Protein2310
stoichiometric coefficient: 1.0

UnificationXref2717
type: UnificationXref
id: REACT_232976
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232976.1

UnificationXref2718
type: UnificationXref
id: CHEBI:16938
db: ChEBI

Metabolism of nitric oxide
type: Pathway
data source: Provenance1
pathway component: eNOS activation and regulation
evidence: Evidence921
xref: RelationshipXref841
xref: UnificationXref6291
xref: UnificationXref6290
pathway order: PathwayStep900
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2715
type: UnificationXref
id: REACT_234682
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234682.1

UnificationXref2716
type: UnificationXref
id: 5592301
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592301

Stoichiometry2509
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

UnificationXref2721
type: UnificationXref
id: DDB0238739
db: UniProt

UnificationXref2720
type: UnificationXref
id: REACT_4982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4982.1

UnificationXref6888
type: UnificationXref
id: 110094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110094

UnificationXref6887
type: UnificationXref
id: CHEBI:17239
db: ChEBI

UnificationXref6889
type: UnificationXref
id: REACT_2815
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2815.2

UnificationXref6884
type: UnificationXref
id: CHEBI:28846
db: ChEBI

UnificationXref6883
type: UnificationXref
id: 5580704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580704

UnificationXref6886
type: UnificationXref
id: REACT_4046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4046.2

UnificationXref6885
type: UnificationXref
id: 110091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110091

UnificationXref6880
type: UnificationXref
id: CHEBI:15918
db: ChEBI

UnificationXref2722
type: UnificationXref
id: 5579066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579066

UnificationXref2723
type: UnificationXref
id: DDB0231285
db: UniProt

UnificationXref6882
type: UnificationXref
id: REACT_3439
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3439.2

UnificationXref2724
type: UnificationXref
id: 5579070
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579070

UnificationXref6881
type: UnificationXref
id: 109378
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109378

UnificationXref2725
type: UnificationXref
id: 5579071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579071

UnificationXref2726
type: UnificationXref
id: 5579072
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579072

UnificationXref2727
type: UnificationXref
id: 5579073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579073

UnificationXref2728
type: UnificationXref
id: 5579074
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579074

UnificationXref2729
type: UnificationXref
id: 5579076
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579076

UnificationXref2732
type: UnificationXref
id: 29996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29996

Stoichiometry2525
type: Stoichiometry
physical entity: SmallMolecule392
stoichiometric coefficient: 2.0

UnificationXref2731
type: UnificationXref
id: CHEBI:16863
db: ChEBI

Stoichiometry2526
type: Stoichiometry
physical entity: Protein2327
stoichiometric coefficient: 1.0

UnificationXref2730
type: UnificationXref
id: REACT_197825
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197825.3

Stoichiometry2523
type: Stoichiometry
physical entity: SmallMolecule724
stoichiometric coefficient: 2.0

Stoichiometry2524
type: Stoichiometry
physical entity: SO2.-
stoichiometric coefficient: 2.0

Stoichiometry2521
type: Stoichiometry
physical entity: SmallMolecule33
stoichiometric coefficient: 2.0

Stoichiometry2522
type: Stoichiometry
physical entity: SO2.-
stoichiometric coefficient: 2.0

Stoichiometry2520
type: Stoichiometry
physical entity: SmallMolecule701
stoichiometric coefficient: 2.0

UnificationXref6897
type: UnificationXref
id: 5580712
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580712

UnificationXref6896
type: UnificationXref
id: 5580710
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580710

UnificationXref6895
type: UnificationXref
id: 5580709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580709

UnificationXref6894
type: UnificationXref
id: DDB0191367
db: UniProt

UnificationXref6899
type: UnificationXref
id: 5581362
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581362

UnificationXref6898
type: UnificationXref
id: REACT_215993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215993.2

UnificationXref2739
type: UnificationXref
id: 29732
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29732

UnificationXref2737
type: UnificationXref
id: REACT_237069
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237069.1

UnificationXref2738
type: UnificationXref
id: CHEBI:17363
db: ChEBI

UnificationXref6893
type: UnificationXref
id: 5580705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580705

UnificationXref2735
type: UnificationXref
id: 5579693
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579693

UnificationXref6892
type: UnificationXref
id: REACT_2602
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2602.2

UnificationXref2736
type: UnificationXref
id: 5579695
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579695

Stoichiometry2529
type: Stoichiometry
physical entity: SO2.-
stoichiometric coefficient: 2.0

UnificationXref6891
type: UnificationXref
id: 110096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110096

UnificationXref2733
type: UnificationXref
id: REACT_2623
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2623.2

Stoichiometry2528
type: Stoichiometry
physical entity: Complex947
stoichiometric coefficient: 4.0

UnificationXref6890
type: UnificationXref
id: CHEBI:17659
db: ChEBI

UnificationXref2734
type: UnificationXref
id: DDB0231287
db: UniProt

Stoichiometry2527
type: Stoichiometry
physical entity: SmallMolecule710
stoichiometric coefficient: 1.0

UnificationXref2741
type: UnificationXref
id: DDB0215011
db: UniProt

Stoichiometry2512
type: Stoichiometry
physical entity: Copper
stoichiometric coefficient: 1.0

UnificationXref2740
type: UnificationXref
id: REACT_3483
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3483.2

Stoichiometry2513
type: Stoichiometry
physical entity: Protein2315
stoichiometric coefficient: 1.0

UnificationXref2743
type: UnificationXref
id: 5579700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579700

Stoichiometry2514
type: Stoichiometry
physical entity: Zinc 2+
stoichiometric coefficient: 1.0

UnificationXref2742
type: UnificationXref
id: 5579699
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579699

Stoichiometry2515
type: Stoichiometry
physical entity: Complex943
stoichiometric coefficient: 4.0

Stoichiometry2510
type: Stoichiometry
physical entity: Protein2314
stoichiometric coefficient: 1.0

Stoichiometry2511
type: Stoichiometry
physical entity: Complex941
stoichiometric coefficient: 2.0

UnificationXref2748
type: UnificationXref
id: REACT_3046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3046.2

UnificationXref2749
type: UnificationXref
id: DDB0231226
db: UniProt

UnificationXref2744
type: UnificationXref
id: 5579702
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579702

Stoichiometry2517
type: Stoichiometry
physical entity: Copper
stoichiometric coefficient: 1.0

UnificationXref2745
type: UnificationXref
id: REACT_243429
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243429.1

Stoichiometry2516
type: Stoichiometry
physical entity: Zn(II)
stoichiometric coefficient: 1.0

UnificationXref2746
type: UnificationXref
id: CHEBI:16332
db: ChEBI

Stoichiometry2519
type: Stoichiometry
physical entity: Complex945
stoichiometric coefficient: 4.0

UnificationXref2747
type: UnificationXref
id: 29790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29790

Stoichiometry2518
type: Stoichiometry
physical entity: PhysicalEntity169
stoichiometric coefficient: 1.0

SequenceSite4884
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4883
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4886
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite4885
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4880
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4882
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite4881
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite4876
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4877
type: SequenceSite
position status: EQUAL
sequence position: 527

SequenceSite4878
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4879
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4875
type: SequenceSite
position status: EQUAL
sequence position: 244

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

SequenceSite4874
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4873
type: SequenceSite
position status: EQUAL
sequence position: 184

SequenceSite4872
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4871
type: SequenceSite
position status: EQUAL
sequence position: 1192

SequenceSite4870
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4869
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite4867
type: SequenceSite
position status: EQUAL
sequence position: 543

SequenceSite4868
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4865
type: SequenceSite
position status: EQUAL
sequence position: 535

SequenceSite4866
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0266781
type: ProteinReference
xref: UnificationXref1340
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266780
type: ProteinReference
xref: UnificationXref9026
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/19487573
type: PublicationXref
id: 19487573
author: Agami, Reuven
author: Rouhanifard, Sara H
author: Holland, Eric C
author: Tuschl, Thomas
author: Huse, Jason T
author: Hambardzumyan, Dolores
author: Brennan, Cameron
author: Sohn-Lee, Cherin
author: le Sage, Carlos
author: Wee, Boyoung
author: Pena, John
db: Pubmed
title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
source: Genes Dev. 23:1327-37
year: 2009

UniProt:DDB0266784
type: ProteinReference
xref: UnificationXref13597
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266782
type: ProteinReference
xref: UnificationXref12682
organism: http://identifiers.org/taxonomy/44689

SequenceSite4898
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4899
type: SequenceSite
position status: EQUAL
sequence position: 260

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

http://identifiers.org/pubmed/7913615
type: PublicationXref
id: 7913615
author: Sheng, H
author: Warner, TD
author: Murad, F
author: Mitchell, JA
db: Pubmed
title: Effects of cyclic GMP on smooth muscle relaxation
source: Adv Pharmacol 26:171-94
year: 1994

SequenceSite4893
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4892
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4891
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite4890
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4897
type: SequenceSite
position status: EQUAL
sequence position: 302

SequenceSite4896
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4895
type: SequenceSite
position status: EQUAL
sequence position: 302

UniProt:DDB0266773
type: ProteinReference
xref: UnificationXref3579
organism: http://identifiers.org/taxonomy/44689

SequenceSite4894
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4889
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite4887
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4888
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite4840
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/1639787
type: PublicationXref
id: 1639787
author: Duncan, TM
author: Tempst, P
author: Fleischer, S
author: McIntyre, JO
author: Erdjument-Bromage, H
author: Marks, AR
db: Pubmed
title: Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart
source: J Biol Chem 267:15459-63
year: 1992

SequenceSite4841
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4842
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2799
type: UnificationXref
id: CHEBI:17713
db: ChEBI

UnificationXref2792
type: UnificationXref
id: REACT_234257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234257.1

Stoichiometry2585
type: Stoichiometry
physical entity: Complex707
stoichiometric coefficient: 1.0

UnificationXref2791
type: UnificationXref
id: 5592302
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592302

Stoichiometry2586
type: Stoichiometry
physical entity: UBIQ_HUMAN
stoichiometric coefficient: 1.0

UnificationXref2794
type: UnificationXref
id: 110644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110644

Stoichiometry2587
type: Stoichiometry
physical entity: Protein2393
stoichiometric coefficient: 1.0

UnificationXref2793
type: UnificationXref
id: CHEBI:16284
db: ChEBI

Stoichiometry2588
type: Stoichiometry
physical entity: Complex977
stoichiometric coefficient: 1.0

UnificationXref2796
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Stoichiometry2589
type: Stoichiometry
physical entity: UBIQ_HUMAN
stoichiometric coefficient: 1.0

UnificationXref2795
type: UnificationXref
id: REACT_5673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5673.1

UnificationXref2798
type: UnificationXref
id: REACT_2628
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2628.2

UnificationXref2797
type: UnificationXref
id: 73566
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73566

SequenceSite4837
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4836
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4839
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2580
type: Stoichiometry
physical entity: Protein2393
stoichiometric coefficient: 1.0

SequenceSite4838
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

Stoichiometry2581
type: Stoichiometry
physical entity: Protein2394
stoichiometric coefficient: 1.0

SequenceSite4833
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2582
type: Stoichiometry
physical entity: Complex707
stoichiometric coefficient: 1.0

SequenceSite4832
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2790
type: UnificationXref
id: REACT_260652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260652.1

Stoichiometry2583
type: Stoichiometry
physical entity: Complex974
stoichiometric coefficient: 1.0

SequenceSite4835
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2584
type: Stoichiometry
physical entity: UBIQ_HUMAN
stoichiometric coefficient: 2.0

SequenceSite4834
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4830
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4831
type: SequenceSite
position status: EQUAL
sequence position: 375

Toll-Like Receptors Cascades
type: Pathway
data source: Provenance1
pathway component: REACT 223004.2
pathway component: REACT 216121.2
pathway component: REACT 226570.2
pathway component: REACT 227663.2
pathway component: REACT 210119.2
pathway component: REACT 219267.2
pathway component: REACT 209933.2
evidence: Evidence2340
xref: RelationshipXref1795
xref: UnificationXref14812
xref: UnificationXref14813
pathway order: PathwayStep2288
pathway order: PathwayStep2300
pathway order: PathwayStep2289
pathway order: PathwayStep2293
pathway order: PathwayStep2292
pathway order: PathwayStep2285
pathway order: PathwayStep2297
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2576
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 2.0

Stoichiometry2577
type: Stoichiometry
physical entity: SmallMolecule7
stoichiometric coefficient: 2.0

Stoichiometry2574
type: Stoichiometry
physical entity: SASP
stoichiometric coefficient: 1.0

Stoichiometry2575
type: Stoichiometry
physical entity: Protein2388
stoichiometric coefficient: 1.0

Stoichiometry2578
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/8330740
type: PublicationXref
id: 8330740
author: Greider, CW
author: Collins, K
db: Pubmed
title: Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation
source: Genes Dev 7:1364-76
year: 1993

Stoichiometry2579
type: Stoichiometry
physical entity: SmallMolecule7
stoichiometric coefficient: 2.0

SequenceSite4829
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4828
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4827
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4826
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4825
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2572
type: Stoichiometry
physical entity: Protein2386
stoichiometric coefficient: 1.0

SequenceSite4824
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2573
type: Stoichiometry
physical entity: Protein2387
stoichiometric coefficient: 1.0

SequenceSite4823
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2570
type: Stoichiometry
physical entity: Complex756
stoichiometric coefficient: 1.0

SequenceSite4822
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2571
type: Stoichiometry
physical entity: Protein2384
stoichiometric coefficient: 1.0

SequenceSite4821
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4860
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4861
type: SequenceSite
position status: EQUAL
sequence position: 541

SequenceSite4862
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4863
type: SequenceSite
position status: EQUAL
sequence position: 531

SequenceSite4864
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:DDB0304415
type: ProteinReference
xref: UnificationXref13676
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0304416
type: ProteinReference
xref: UnificationXref8304
organism: http://identifiers.org/taxonomy/44689

SequenceSite4855
type: SequenceSite
position status: EQUAL
sequence position: 545

SequenceSite4854
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4857
type: SequenceSite
position status: EQUAL
sequence position: 539

SequenceSite4856
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4859
type: SequenceSite
position status: EQUAL
sequence position: 548

SequenceSite4858
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4852
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4853
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite4850
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0266730
type: ProteinReference
xref: UnificationXref7810
organism: http://identifiers.org/taxonomy/44689

SequenceSite4851
type: SequenceSite
position status: EQUAL
sequence position: 444

UniProt:DDB0266732
type: ProteinReference
xref: UnificationXref7814
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266733
type: ProteinReference
xref: UnificationXref7820
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266734
type: ProteinReference
xref: UnificationXref7812
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266735
type: ProteinReference
xref: UnificationXref7822
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2598
type: Stoichiometry
physical entity: PhysicalEntity8
stoichiometric coefficient: 1.0

Stoichiometry2599
type: Stoichiometry
physical entity: PhysicalEntity174
stoichiometric coefficient: 1.0

Stoichiometry2596
type: Stoichiometry
physical entity: PhysicalEntity174
stoichiometric coefficient: 1.0

Stoichiometry2597
type: Stoichiometry
physical entity: Complex898
stoichiometric coefficient: 1.0

Stoichiometry2594
type: Stoichiometry
physical entity: Complex898
stoichiometric coefficient: 1.0

SequenceSite4846
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

Stoichiometry2595
type: Stoichiometry
physical entity: PhysicalEntity8
stoichiometric coefficient: 1.0

SequenceSite4845
type: SequenceSite
position status: EQUAL
sequence position: 451

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

Stoichiometry2592
type: Stoichiometry
physical entity: PhysicalEntity8
stoichiometric coefficient: 1.0

SequenceSite4844
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2593
type: Stoichiometry
physical entity: PhysicalEntity173
stoichiometric coefficient: 1.0

SequenceSite4843
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2590
type: Stoichiometry
physical entity: Protein2394
stoichiometric coefficient: 1.0

Stoichiometry2591
type: Stoichiometry
physical entity: Complex978
stoichiometric coefficient: 1.0

SequenceSite4849
type: SequenceSite
position status: EQUAL
sequence position: 450

UniProt:DDB0304408
type: ProteinReference
xref: UnificationXref1138
organism: http://identifiers.org/taxonomy/44689

SequenceSite4848
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4847
type: SequenceSite
position status: EQUAL
sequence position: 445

Cell Cycle
type: Pathway
data source: Provenance1
pathway component: REACT 227995.2
pathway component: REACT 254235.1
pathway component: REACT 232859.1
evidence: Evidence1464
xref: UnificationXref9558
xref: UnificationXref9559
pathway order: PathwayStep1439
pathway order: PathwayStep1421
pathway order: PathwayStep1305
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266712
type: ProteinReference
xref: UnificationXref5057
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266710
type: ProteinReference
xref: UnificationXref5051
organism: http://identifiers.org/taxonomy/44689

APC-Cdc20 mediated degradation of Nek2A
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1054
pathway component: BiochemicalReaction1055
pathway component: BiochemicalReaction1056
evidence: Evidence1619
xref: UnificationXref10579
xref: UnificationXref10580
pathway order: PathwayStep1586
pathway order: PathwayStep1585
pathway order: PathwayStep1587
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266713
type: ProteinReference
xref: UnificationXref5053
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231483
type: ProteinReference
xref: UnificationXref7342
organism: http://identifiers.org/taxonomy/44689

Molecules associated with elastic fibres
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction82
evidence: Evidence159
xref: UnificationXref1444
xref: UnificationXref1443
pathway order: PathwayStep143
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

di-mu-sulfido-diiron(2+) [ChEBI:33737]
type: SmallMoleculeReference
name: [Fe2S2](2+)
name: [2Fe-2S](2+)
name: di-mu-sulfido-diiron(2+)
name: [Fe2(mu-S)2](2+)
xref: UnificationXref8393

http://identifiers.org/pubmed/9949182
type: PublicationXref
id: 9949182
author: Pébusque, MJ
author: Grégoire, MJ
author: Zhang, B
author: Jonveaux, P
author: Popovici, C
author: Lafage-Pochitaloff, M
author: Birnbaum, D
db: Pubmed
title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
source: Blood 93:1381-9
year: 1999

[Fe2S2](+)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(1+)
name: [2Fe-2S](1+)
name: di-mu-sulfido-diiron(1+) [ChEBI:33738]
name: [Fe2(mu-S)2](+)
xref: UnificationXref8399

[Fe2(mu-S)2](0)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(0) [ChEBI:33739]
name: di-mu-sulfido-diiron(0)
name: 2Fe-2S cluster
name: [Fe2S2](0)
xref: UnificationXref8408

http://identifiers.org/pubmed/8250832
type: PublicationXref
id: 8250832
author: Serhan, CN
author: Takahashi, Y
author: Chen, XS
author: Yamamoto, S
author: Romano, M
author: Funk, CD
db: Pubmed
title: Lipoxin synthase activity of human platelet 12-lipoxygenase
source: Biochem J 296:127-33
year: 1993

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

UnificationXref6907
type: UnificationXref
id: CHEBI:18075
db: ChEBI

SequenceSite4803
type: SequenceSite
position status: EQUAL
sequence position: 375

UnificationXref6906
type: UnificationXref
id: REACT_5210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5210.2

SequenceSite4804
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6909
type: UnificationXref
id: REACT_2972
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2972.2

SequenceSite4805
type: SequenceSite
position status: EQUAL
sequence position: 375

UnificationXref6908
type: UnificationXref
id: 110095
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110095

SequenceSite4806
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6903
type: UnificationXref
id: 5580800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580800

UnificationXref6902
type: UnificationXref
id: REACT_4611
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4611.2

SequenceSite4800
type: SequenceSite
position status: EQUAL
sequence position: 1

Glycogen breakdown (glycogenolysis)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction200
pathway component: BiochemicalReaction201
pathway component: BiochemicalReaction202
pathway component: BiochemicalReaction199
pathway component: BiochemicalReaction198
evidence: Evidence354
xref: RelationshipXref247
xref: UnificationXref2695
xref: UnificationXref2694
pathway order: PathwayStep335
pathway order: PathwayStep336
pathway order: PathwayStep333
pathway order: PathwayStep334
pathway order: PathwayStep332
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref6905
type: UnificationXref
id: 110093
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110093

SequenceSite4801
type: SequenceSite
position status: EQUAL
sequence position: 375

UnificationXref6904
type: UnificationXref
id: CHEBI:28850
db: ChEBI

SequenceSite4802
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4807
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4808
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4809
type: SequenceSite
position status: EQUAL
sequence position: 375

UnificationXref6900
type: UnificationXref
id: REACT_240539
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240539.1

UnificationXref6901
type: UnificationXref
id: 109382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109382

SequenceSite4816
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4817
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4814
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4815
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4812
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4813
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4810
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4811
type: SequenceSite
position status: EQUAL
sequence position: 375

UniProt:DDB0266708
type: ProteinReference
xref: UnificationXref3851
organism: http://identifiers.org/taxonomy/44689

SequenceSite4818
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0266709
type: ProteinReference
xref: UnificationXref9352
organism: http://identifiers.org/taxonomy/44689

SequenceSite4819
type: SequenceSite
position status: EQUAL
sequence position: 375

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

SequenceSite4820
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

http://identifiers.org/pubmed/9883880
type: PublicationXref
id: 9883880
author: Callebaut, I
author: Dehoux, P
author: Cossart, P
db: Pubmed
title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
source: FEBS Lett 441:181-5
year: 1998

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref3119

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305115
data source: Provenance1
name: Cdc6
name: DDB0305115
xref: UnificationXref9183
feature: FragmentFeature1541
cellular location: GO_0005829
comment: Reactome DB_ID: 5578903
display name: CDC6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232230
data source: Provenance1
name: DNA-binding protein PO-GA
name: Activator 1 140 kDa subunit
name: DDB0232230
name: RFC140
name: RF-C 140 kDa subunit
name: Activator 1 large subunit
name: A1 140 kDa subunit
name: Replication factor C large subunit
xref: UnificationXref9215
feature: FragmentFeature1545
cellular location: GO_0005654
comment: Reactome DB_ID: 5578927
display name: RFC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266354
data source: Provenance1
name: PSF2p
name: DDB0266354
xref: UnificationXref9207
feature: FragmentFeature1544
cellular location: GO_0005654
comment: Reactome DB_ID: 5583692
display name: GINS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266356
data source: Provenance1
name: DDB0266356
name: SLD5P
xref: UnificationXref9205
feature: FragmentFeature1543
cellular location: GO_0005654
comment: Reactome DB_ID: 5583696
display name: GINS4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266353
data source: Provenance1
name: PSF1p
name: DDB0266353
xref: UnificationXref9203
feature: FragmentFeature1542
cellular location: GO_0005654
comment: Reactome DB_ID: 5583688
display name: GINS1

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

Homologues of CDK4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9258
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581419

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229424
data source: Provenance1
name: DDB0229424
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref9254
feature: FragmentFeature1548
cellular location: GO_0005829
comment: Reactome DB_ID: 5581415
display name: CDK4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232265
data source: Provenance1
name: DNA ligase I
name: Polydeoxyribonucleotide synthase (ATP)
name: DDB0232265
xref: UnificationXref9236
feature: FragmentFeature1546
cellular location: GO_0005654
comment: Reactome DB_ID: 5578943
display name: LIG1

phospho-p-T286-CCND1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
xref: UnificationXref9248
feature: FragmentFeature1547
feature: ModificationFeature268
cellular location: GO_0005654
comment: Reactome DB_ID: 5581410

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230050
data source: Provenance1
name: DDB0230050
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref9255
feature: FragmentFeature1549
cellular location: GO_0005829
comment: Reactome DB_ID: 5581416
display name: CDK4

phospho-p-CDC6
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305115
data source: Provenance1
xref: UnificationXref9180
feature: FragmentFeature1540
feature: ModificationFeature267
cellular location: GO_0005829
comment: Reactome DB_ID: 5578901

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233110
data source: Provenance1
name: Origin recognition complex subunit 1
name: Replication control protein 1
name: DDB0233110
name: Orc1
xref: UnificationXref9170
feature: FragmentFeature1539
cellular location: GO_0005829
comment: Reactome DB_ID: 5578730
display name: ORC1

phospho-p-S,T-ORC1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233110
data source: Provenance1
xref: UnificationXref9166
feature: FragmentFeature1538
feature: ModificationFeature266
feature: ModificationFeature265
cellular location: GO_0005654
comment: Reactome DB_ID: 5578684

phospho-p-S795-RB1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
xref: UnificationXref9134
feature: FragmentFeature1537
feature: ModificationFeature264
cellular location: GO_0005654
comment: Reactome DB_ID: 5578985

Ribonucleotide reductase small chain
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238223
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: DDB0238223
xref: UnificationXref9115
feature: FragmentFeature1536
cellular location: GO_0005654
comment: Reactome DB_ID: 5587909
display name: RRM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230113
data source: Provenance1
name: DDB0230113
name: Dihydrofolate reductase
xref: UnificationXref9114
feature: FragmentFeature1535
cellular location: GO_0005654
comment: Reactome DB_ID: 5587908
display name: DHFR

UnificationXref6962
type: UnificationXref
id: 111814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111814

UnificationXref6963
type: UnificationXref
id: REACT_5432
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5432.2

UnificationXref6960
type: UnificationXref
id: 111809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111809

UnificationXref6961
type: UnificationXref
id: REACT_3101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3101.2

UnificationXref6966
type: UnificationXref
id: REACT_4262
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4262.2

UnificationXref6967
type: UnificationXref
id: 111785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111785

UniProt:DDB0231418
type: ProteinReference
xref: UnificationXref8042
organism: http://identifiers.org/taxonomy/44689

UnificationXref6964
type: UnificationXref
id: 5582263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582263

UniProt:DDB0231419
type: ProteinReference
xref: UnificationXref8074
organism: http://identifiers.org/taxonomy/44689

UnificationXref6965
type: UnificationXref
id: 111783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111783

UniProt:DDB0231417
type: ProteinReference
xref: UnificationXref8028
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231416
type: ProteinReference
xref: UnificationXref7998
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231415
type: ProteinReference
xref: UnificationXref8012
organism: http://identifiers.org/taxonomy/44689

UnificationXref6969
type: UnificationXref
id: 111784
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111784

UniProt:DDB0231414
type: ProteinReference
xref: UnificationXref8066
organism: http://identifiers.org/taxonomy/44689

UnificationXref6968
type: UnificationXref
id: REACT_5414
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5414.2

http://identifiers.org/pubmed/12920597
type: PublicationXref
id: 12920597
author: Hamm, LL
author: Nakhoul, NL
db: Pubmed
title: Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters
source: Pflugers Arch 447:807-12
year: 2004

UniProt:DDB0231413
type: ProteinReference
xref: UnificationXref8085
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231410
type: ProteinReference
xref: UnificationXref6992
organism: http://identifiers.org/taxonomy/44689

E2F1 targets
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Ribonucleotide reductase small chain
xref: UnificationXref9116
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587910

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185028
data source: Provenance1
name: Cdk1
name: Cdc2
name: DDB0185028
xref: UnificationXref9113
feature: FragmentFeature1534
cellular location: GO_0005654
comment: Reactome DB_ID: 5587907
display name: CDK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304902
data source: Provenance1
name: p35
name: MNAT1
name: DDB0304902
name: CDK-activating kinase assembly factor MAT1
name: Cyclin G1 interacting protein
name: RING finger protein MAT1
name: CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35) (Cyclin G1 interacting protein)
name: MAT1
name: CDK7/cyclin H assembly factor
name: Menage a trois
xref: UnificationXref9098
feature: FragmentFeature1532
cellular location: GO_0005654
comment: Reactome DB_ID: 5580998
display name: p36

phospho-p-RB1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
xref: UnificationXref9105
feature: ModificationFeature263
feature: FragmentFeature1533
cellular location: GO_0005654
comment: Reactome DB_ID: 5583745

STK1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191429
data source: Provenance1
name: CAK1
name: CDK7
name: Cdk7
name: Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1)
name: Note: the coordinates are copied over from Homo sapiens.
name: CDK-activating kinase
name: Cell division protein kinase 7
name: DDB0191429
name: TFIIH basal transcription factor complex kinase subunit
name: P39 Mo15
name: 39 kDa protein kinase
xref: UnificationXref9094
feature: FragmentFeature1530
cellular location: GO_0005654
comment: Reactome DB_ID: 5580990
display name: CAK

phospho-p-T160-CDK2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185028
data source: Provenance1
xref: UnificationXref9091
feature: FragmentFeature1529
feature: ModificationFeature262
cellular location: GO_0005654
comment: Reactome DB_ID: 5583465

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231776
data source: Provenance1
name: p34
name: DDB0231776
name: CCNH
name: MO15-associated protein
name: Cyclin H
xref: UnificationXref9096
feature: FragmentFeature1531
cellular location: GO_0005654
comment: Reactome DB_ID: 5580994
display name: p37

Homologues of PKMYT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9080
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5579004

phospho-p-CDK2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185028
data source: Provenance1
xref: UnificationXref9070
feature: FragmentFeature1526
feature: ModificationFeature261
cellular location: GO_0005654
comment: Reactome DB_ID: 5578961

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216398
data source: Provenance1
name: DDB0216398
name: Myt1 kinase
xref: UnificationXref9079
feature: FragmentFeature1528
cellular location: GO_0005654
comment: Reactome DB_ID: 5579003
display name: PKMYT1

Signalling to ERK5
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1406
pathway component: BiochemicalReaction1405
evidence: Evidence2198
xref: UnificationXref14008
xref: UnificationXref14007
pathway order: PathwayStep2158
pathway order: PathwayStep2159
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229384
data source: Provenance1
name: Myt1 kinase
name: DDB0229384
xref: UnificationXref9077
feature: FragmentFeature1527
cellular location: GO_0005654
comment: Reactome DB_ID: 5578999
display name: PKMYT1

UnificationXref6950
type: UnificationXref
id: DDB0233050
db: UniProt

L-serine removal
type: SequenceModificationVocabulary
xref: UnificationXref1840

UnificationXref6951
type: UnificationXref
id: 5580815
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580815

UnificationXref6952
type: UnificationXref
id: 5580814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580814

UnificationXref6953
type: UnificationXref
id: 5582260
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582260

UnificationXref6954
type: UnificationXref
id: REACT_204074
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204074.2

UniProt:DDB0231409
type: ProteinReference
xref: UnificationXref13336
organism: http://identifiers.org/taxonomy/44689

UnificationXref6955
type: UnificationXref
id: 5582262
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582262

UnificationXref6956
type: UnificationXref
id: 5582261
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582261

UniProt:DDB0231404
type: ProteinReference
xref: UnificationXref8254
organism: http://identifiers.org/taxonomy/44689

UnificationXref6958
type: UnificationXref
id: 111349
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111349

UnificationXref6957
type: UnificationXref
id: 5582264
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582264

UnificationXref6959
type: UnificationXref
id: REACT_4307
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4307.1

UniProt:DDB0231400
type: ProteinReference
xref: UnificationXref6387
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231402
type: ProteinReference
xref: UnificationXref2319
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231401
type: ProteinReference
xref: UnificationXref2321
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
name: DDB0185035
name: G1/S-specific cyclin E1
xref: UnificationXref9061
feature: FragmentFeature1524
cellular location: GO_0005829
comment: Reactome DB_ID: 5578950
display name: CCNE1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
name: DDB0185035
name: G1/S-Specific cyclin E2
xref: UnificationXref9062
feature: FragmentFeature1525
cellular location: GO_0005829
comment: Reactome DB_ID: 5578951
display name: CCNE2

Cyclin E
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9069
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5578959

UnificationXref6980
type: UnificationXref
id: 5582270
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582270

UnificationXref2703
type: UnificationXref
id: REACT_5240
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5240.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref9049
feature: FragmentFeature1520
cellular location: GO_0005654
comment: Reactome DB_ID: 5578709
display name: DDB0201651

UnificationXref6981
type: UnificationXref
id: 5582273
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582273

UnificationXref2702
type: UnificationXref
id: 30393
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30393

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref9048
feature: FragmentFeature1519
cellular location: GO_0005654
comment: Reactome DB_ID: 5578708
display name: DDB0201651

UnificationXref2701
type: UnificationXref
id: CHEBI:17378
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref9047
feature: FragmentFeature1518
cellular location: GO_0005654
comment: Reactome DB_ID: 5578707
display name: DDB0201651

UnificationXref2700
type: UnificationXref
id: REACT_3892
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3892.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref9046
feature: FragmentFeature1517
cellular location: GO_0005654
comment: Reactome DB_ID: 5578706
display name: DDB0201651

UnificationXref2707
type: UnificationXref
id: REACT_260537
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260537.1

Cyclin E
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9063
cellular location: GO_0005829
comment: Reactome DB_ID: 5578952
comment: Converted from EntitySet in Reactome

UnificationXref2706
type: UnificationXref
id: 5592300
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592300

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185028
data source: Provenance1
name: Cell division protein kinase 2
name: p33 protein kinase
name: Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2)
name: DDB0185028
name: Cdk2
xref: UnificationXref9060
feature: FragmentFeature1523
cellular location: GO_0005829
comment: Reactome DB_ID: 5578946
display name: CDK2

UnificationXref2705
type: UnificationXref
id: REACT_235902
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235902.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref9051
feature: FragmentFeature1522
cellular location: GO_0005654
comment: Reactome DB_ID: 5578711
display name: DDB0201651

UnificationXref2704
type: UnificationXref
id: 5579055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579055

ubiquitin (UBC 8)
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref9050
feature: FragmentFeature1521
cellular location: GO_0005654
comment: Reactome DB_ID: 5578710
display name: DDB0201651

UnificationXref6988
type: UnificationXref
id: 111745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref6989
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref6986
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

UnificationXref2709
type: UnificationXref
id: 29452
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29452

UnificationXref6987
type: UnificationXref
id: CHEBI:17858
db: ChEBI

UnificationXref2708
type: UnificationXref
id: CHEBI:18307
db: ChEBI

UnificationXref6984
type: UnificationXref
id: CHEBI:16856
db: ChEBI

UnificationXref6985
type: UnificationXref
id: 29450
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

UnificationXref6982
type: UnificationXref
id: 5582275
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582275

UnificationXref6983
type: UnificationXref
id: REACT_213314
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213314.2

UniProt:DDB0231438
type: ProteinReference
xref: UnificationXref7150
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

ubiquitin (UBC 2)
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref9044
feature: FragmentFeature1515
cellular location: GO_0005654
comment: Reactome DB_ID: 5578704
display name: DDB0201651

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref9045
feature: FragmentFeature1516
cellular location: GO_0005654
comment: Reactome DB_ID: 5578705
display name: DDB0201651

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235212
data source: Provenance1
name: CKS1B
name: DDB0235212
xref: UnificationXref9033
feature: FragmentFeature1508
cellular location: GO_0005654
comment: Reactome DB_ID: 5589141
display name: Cks1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185043
data source: Provenance1
name: DDB0185043
name: Skp1
xref: UnificationXref9029
feature: FragmentFeature1507
cellular location: GO_0005654
comment: Reactome DB_ID: 5589144
display name: SKP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191355
data source: Provenance1
name: RPS27A(1-76)
name: ubiquitin (RPS27A)
xref: UnificationXref9038
feature: FragmentFeature1509
cellular location: GO_0005654
comment: Reactome DB_ID: 5578689
display name: DDB0191355

UnificationXref6970
type: UnificationXref
id: REACT_4892
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4892.2

UBIQ_HUMAN
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: ubiquitin (UBC 8)
member physical entity: UBC(1-76)
member physical entity: ubiquitin (UBC 2)
xref: UnificationXref9052
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5578712
display name: ubiquitin

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214921
data source: Provenance1
name: UBB(1-76)
name: DDB0214921
name: ubiquitin (UBB 1)
xref: UnificationXref9040
feature: FragmentFeature1511
cellular location: GO_0005654
comment: Reactome DB_ID: 5578697
display name: UBB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214925
data source: Provenance1
name: UBA52(1-76)
name: ubiquitin (UBA52)
xref: UnificationXref9039
feature: FragmentFeature1510
cellular location: GO_0005654
comment: Reactome DB_ID: 5578693
display name: DDB0214925

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214921
data source: Provenance1
name: ubiquitin (UBB 3)
name: UBB(153-228)
xref: UnificationXref9042
feature: FragmentFeature1513
cellular location: GO_0005654
comment: Reactome DB_ID: 5578699
display name: DDB0214921

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214921
data source: Provenance1
name: ubiquitin (UBB 2)
name: UBB(77-152)
xref: UnificationXref9041
feature: FragmentFeature1512
cellular location: GO_0005654
comment: Reactome DB_ID: 5578698
display name: DDB0214921

UnificationXref6975
type: UnificationXref
id: 5582271
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582271

UnificationXref6976
type: UnificationXref
id: 111793
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111793

UBC(1-76)
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201651
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: DDB0201651
xref: UnificationXref9043
feature: FragmentFeature1514
cellular location: GO_0005654
comment: Reactome DB_ID: 5578703
display name: UBC

UnificationXref6977
type: UnificationXref
id: REACT_4986
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4986.2

UnificationXref6978
type: UnificationXref
id: 5582272
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582272

UnificationXref6971
type: UnificationXref
id: 111786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111786

UnificationXref6972
type: UnificationXref
id: REACT_5731
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5731.2

UnificationXref6973
type: UnificationXref
id: 5582265
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582265

UnificationXref6974
type: UnificationXref
id: 5582268
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582268

UniProt:DDB0231422
type: ProteinReference
xref: UnificationXref14405
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231421
type: ProteinReference
xref: UnificationXref370
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231425
type: ProteinReference
xref: UnificationXref2488
organism: http://identifiers.org/taxonomy/44689

UnificationXref6979
type: UnificationXref
id: 5582269
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582269

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266780
data source: Provenance1
name: DDB0266780
name: Skp1
xref: UnificationXref9027
feature: FragmentFeature1506
cellular location: GO_0005654
comment: Reactome DB_ID: 5589143
display name: SKP1

UnificationXref6923
type: UnificationXref
id: 5587833
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587833

UnificationXref6922
type: UnificationXref
id: REACT_224149
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224149.2

UnificationXref6921
type: UnificationXref
id: 5580822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580822

Homologues of SKP1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref9030
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589145

UnificationXref6920
type: UnificationXref
id: 5580820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580820

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191107
data source: Provenance1
name: DDB0191107
name: Skp1
xref: UnificationXref9025
feature: FragmentFeature1505
cellular location: GO_0005654
comment: Reactome DB_ID: 5589142
display name: SKP1

phospho-p-T401,S672,S1035-RBL2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
xref: UnificationXref9019
feature: ModificationFeature260
feature: ModificationFeature258
feature: ModificationFeature259
feature: FragmentFeature1503
cellular location: GO_0005654
comment: Reactome DB_ID: 5588909

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185191
data source: Provenance1
name: Cul-1_1
name: DDB0185191
xref: UnificationXref9023
feature: FragmentFeature1504
cellular location: GO_0005654
comment: Reactome DB_ID: 5589146
display name: CUL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191428
data source: Provenance1
name: PP2A-regulatory subunit B55 alpha isoform
name: DDB0191428
xref: UnificationXref9011
feature: FragmentFeature1501
cellular location: GO_0005654
comment: Reactome DB_ID: 5589122
display name: PPP2R2A

DDB0219848
type: Protein
entity reference: UniProt:DDB0219848
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PP2A-regulatory subunit B55 alpha isoform
xref: UnificationXref9013
feature: FragmentFeature1502
cellular location: GO_0005654
comment: Reactome DB_ID: 5589123
display name: PPP2R2A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0206306
data source: Provenance1
name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
name: P2R3B_HUMAN
name: DDB0206306
xref: UnificationXref9009
feature: FragmentFeature1500
cellular location: GO_0005654
comment: Reactome DB_ID: 5582513
display name: PPP2R3B

Homologues of PPP2R2A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0219848
xref: UnificationXref9014
cellular location: GO_0005654
comment: Reactome DB_ID: 5589124
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
name: DDB0185035
name: G1/S-specific cyclin E1
xref: UnificationXref8990
feature: FragmentFeature1498
cellular location: GO_0005654
comment: Reactome DB_ID: 5578956
display name: CCNE1

phospho-p-T369,S640,S964,S975-RBL1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
xref: UnificationXref9007
feature: ModificationFeature257
feature: ModificationFeature256
feature: ModificationFeature255
feature: FragmentFeature1499
feature: ModificationFeature254
cellular location: GO_0005654
comment: Reactome DB_ID: 5588917

UniProt:DDB0231452
type: ProteinReference
xref: UnificationXref13296
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231453
type: ProteinReference
xref: UnificationXref13303
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231450
type: ProteinReference
xref: UnificationXref13273
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231451
type: ProteinReference
xref: UnificationXref13289
organism: http://identifiers.org/taxonomy/44689

UnificationXref6926
type: UnificationXref
id: REACT_248619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248619.1

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

chromosome, centromeric region
type: CellularLocationVocabulary
xref: UnificationXref9297

UnificationXref6927
type: UnificationXref
id: DDB0216771
db: UniProt

UnificationXref6924
type: UnificationXref
id: 5587834
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587834

UniProt:DDB0231459
type: ProteinReference
xref: UnificationXref7572
organism: http://identifiers.org/taxonomy/44689

UnificationXref6925
type: UnificationXref
id: 5587836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587836

UniProt:DDB0231456
type: ProteinReference
xref: UnificationXref13473
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
type: Pathway
data source: Provenance1
pathway component: REACT 204254.2
pathway component: REACT 218563.2
evidence: Evidence2347
xref: UnificationXref14838
xref: UnificationXref14837
xref: RelationshipXref1804
pathway order: PathwayStep2303
pathway order: PathwayStep2307
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref6928
type: UnificationXref
id: 5582238
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582238

UnificationXref6929
type: UnificationXref
id: 5582234
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582234

UnificationXref6910
type: UnificationXref
id: 5580801
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580801

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234190
data source: Provenance1
name: HDA1_HUMAN
name: Histone deacetylase 1
name: DDB0234190
xref: UnificationXref8981
feature: FragmentFeature1496
cellular location: GO_0005654
comment: Reactome DB_ID: 5585398
display name: HDAC1

Cyclin E
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8991
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5578957

UnificationXref6912
type: UnificationXref
id: 5580805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580805

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
name: DDB0185035
name: G1/S-Specific cyclin E2
xref: UnificationXref8989
feature: FragmentFeature1497
cellular location: GO_0005654
comment: Reactome DB_ID: 5578955
display name: CCNE2

UnificationXref6911
type: UnificationXref
id: DDB0230101
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220101
data source: Provenance1
name: DP-2
name: DDB0220101
name: TFDP2
xref: UnificationXref8969
feature: FragmentFeature1492
cellular location: GO_0005654
comment: Reactome DB_ID: 5588903
display name: DP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232078
data source: Provenance1
name: DDB0232078
name: Lin-9
xref: UnificationXref8973
feature: FragmentFeature1493
cellular location: GO_0005654
comment: Reactome DB_ID: 5589079
display name: LIN9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232003
data source: Provenance1
name: RbAp48
name: CAF1C
name: DDB0232003
xref: UnificationXref8975
feature: FragmentFeature1494
cellular location: GO_0005654
comment: Reactome DB_ID: 5589083
display name: RBBP4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304883
data source: Provenance1
name: Lin-54
name: DDB0304883
xref: UnificationXref8977
feature: FragmentFeature1495
cellular location: GO_0005654
comment: Reactome DB_ID: 5589075
display name: LIN54

E2F-5
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216397
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Transcription factor E2F5 (E2F-5)
name: DDB0216397
name: Transcription factor E2F5
xref: UnificationXref8965
feature: FragmentFeature1490
cellular location: GO_0005654
comment: Reactome DB_ID: 5588901
display name: E2F5

TFDP1, TFDP2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8970
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588904

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220101
data source: Provenance1
name: DRTF1
name: E2F dimerization partner 1
name: DDB0220101
name: Transcription factor Dp-1
name: DRTF1- polypeptide-1
name: Transcription factor DP-1 (E2F dimerization partner 1)(DRTF1-polypeptide-1) (DRTF1)
name: TFDP1
xref: UnificationXref8968
feature: FragmentFeature1491
cellular location: GO_0005654
comment: Reactome DB_ID: 5578982
display name: DP-1

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

UnificationXref6913
type: UnificationXref
id: 5580806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580806

UniProt:DDB0231448
type: ProteinReference
xref: UnificationXref10379
organism: http://identifiers.org/taxonomy/44689

UnificationXref6914
type: UnificationXref
id: 5580808
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580808

UnificationXref6915
type: UnificationXref
id: REACT_207007
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207007.2

UnificationXref6916
type: UnificationXref
id: 5581363
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581363

UnificationXref6917
type: UnificationXref
id: REACT_239292
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239292.1

UnificationXref6918
type: UnificationXref
id: DDB0230162
db: UniProt

UniProt:DDB0231445
type: ProteinReference
xref: UnificationXref7859
organism: http://identifiers.org/taxonomy/44689

UnificationXref6919
type: UnificationXref
id: 5580819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580819

UnificationXref6945
type: UnificationXref
id: 5582253
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582253

E2F4/5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: E2F-5
xref: UnificationXref8966
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588902

L-histidine removal
type: SequenceModificationVocabulary
xref: UnificationXref2261

UnificationXref6944
type: UnificationXref
id: 5582252
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582252

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216397
data source: Provenance1
name: E2F-4
name: Transcription factor E2F4 (E2F-4)
name: DDB0216397
name: Transcription factor E2F4
xref: UnificationXref8964
feature: FragmentFeature1489
cellular location: GO_0005654
comment: Reactome DB_ID: 5588900
display name: E2F4

glycine removal
type: SequenceModificationVocabulary
xref: UnificationXref2263

UnificationXref6943
type: UnificationXref
id: 5582251
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582251

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231510
data source: Provenance1
name: DDB0231510
xref: UnificationXref8959
feature: FragmentFeature1487
cellular location: GO_0005654
comment: Reactome DB_ID: 5589071
display name: TOP2A

UnificationXref6942
type: UnificationXref
id: DDB0238223
db: UniProt

p130
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: p130 (RBL2)
name: DDB0232004
xref: UnificationXref8963
feature: FragmentFeature1488
cellular location: GO_0005654
comment: Reactome DB_ID: 5588899
display name: RBL2

L-glutamic acid removal
type: SequenceModificationVocabulary
xref: UnificationXref2270

UnificationXref6941
type: UnificationXref
id: REACT_5725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5725.2

L-cysteine removal
type: SequenceModificationVocabulary
xref: UnificationXref2257

Signalling to RAS
type: Pathway
data source: Provenance1
pathway component: p38MAPK events
pathway component: REACT 202664.2
evidence: Evidence2187
xref: UnificationXref13979
xref: UnificationXref13980
xref: RelationshipXref1733
pathway order: PathwayStep2148
pathway order: PathwayStep40
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref6940
type: UnificationXref
id: 111736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111736

L-arginine removal
type: SequenceModificationVocabulary
xref: UnificationXref2255

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232231
data source: Provenance1
name: Replication factor C 40 kDa subunit
name: DDB0232231
name: RFC40
name: A1 40 kDa subunit
name: RF-C 40 kDa subunit
name: Activator 1 40 kDa subunit
xref: UnificationXref8914
feature: FragmentFeature1481
cellular location: GO_0005654
comment: Reactome DB_ID: 5578923
display name: RFC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232229
data source: Provenance1
name: Replication factor C subunit 5
name: Activator 1 36 kDa subunit
name: A1 36 kDa subunit
name: DDB0232229
name: RF-C 36 kDa subunit
name: RFC36
name: Activator 1 36 kDa subunit (Replication factor C 36 kDa subunit) (A1 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
name: Replication factor C 36 kDa subunit
xref: UnificationXref8916
feature: FragmentFeature1482
cellular location: GO_0005654
comment: Reactome DB_ID: 5578911
display name: RFC5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231779
data source: Provenance1
name: Cyclin
name: DDB0231779
name: Proliferating cell nuclear antigen
xref: UnificationXref8956
feature: FragmentFeature1485
cellular location: GO_0005654
comment: Reactome DB_ID: 5578934
display name: PCNA

p107 (RBL1)
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: p107
name: DDB0232004
xref: UnificationXref8957
feature: FragmentFeature1486
cellular location: GO_0005654
comment: Reactome DB_ID: 5588911
display name: RBL1

DDB0232233
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232233
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: RF-C 37 kDa subunit
name: A1 37 kDa subunit
name: RFC37
name: Replication factor C 37 kDa subunit
name: Activator 1 37 kDa subunit
xref: UnificationXref8918
feature: FragmentFeature1483
cellular location: GO_0005654
comment: Reactome DB_ID: 5578915
display name: RFC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304834
data source: Provenance1
name: DDB0304834
name: HsMad1
xref: UnificationXref8929
feature: FragmentFeature1484
cellular location: GO_0005829
comment: Reactome DB_ID: 5582676
display name: MAD1L1

UniProt:DDB0231473
type: ProteinReference
xref: UnificationXref8100
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231478
type: ProteinReference
xref: UnificationXref7117
organism: http://identifiers.org/taxonomy/44689

UnificationXref6948
type: UnificationXref
id: 5582256
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582256

UnificationXref6949
type: UnificationXref
id: 5582257
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582257

UnificationXref6946
type: UnificationXref
id: 5582255
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582255

UnificationXref6947
type: UnificationXref
id: REACT_251715
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251715.1

UnificationXref6932
type: UnificationXref
id: CHEBI:16174
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233011
data source: Provenance1
name: DDB0233011
xref: UnificationXref8898
feature: FragmentFeature1476
cellular location: GO_0005654
comment: Reactome DB_ID: 5583661
display name: RAD9B

UnificationXref6931
type: UnificationXref
id: 5582242
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582242

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233010
data source: Provenance1
name: DDB0233010
xref: UnificationXref8901
feature: FragmentFeature1477
cellular location: GO_0005654
comment: Reactome DB_ID: 5583666
display name: HUS1

UnificationXref6934
type: UnificationXref
id: REACT_4457
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4457.2

Single-stranded DNA-binding protein
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233023
data source: Provenance1
name: RPA70
name: Note: the coordinates are copied over from Homo sapiens.
name: RP-A
name: Replication factor-A protein 1
name: RF-A
name: DNA Replication factor A protein A1 (70kD)
name: Replication protein A 70 kDa DNA-binding subunit
name: DDB0233023
xref: UnificationXref8906
feature: FragmentFeature1478
cellular location: GO_0005654
comment: Reactome DB_ID: 5581028
display name: RPA1

UnificationXref6933
type: UnificationXref
id: 110090
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110090

RF-C 38 kDa subunit
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232232
data source: Provenance1
name: DDB0232232
name: Note: the coordinates are copied over from Homo sapiens.
name: Replication factor C subunit 3
name: Replication factor C 38 kDa subunit
name: A1 38 kDa subunit
name: RFC38
name: Activator 1 38 kDa subunit
xref: UnificationXref8910
feature: FragmentFeature1479
cellular location: GO_0005654
comment: Reactome DB_ID: 5578919
display name: RFC3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233002
data source: Provenance1
name: Cell cycle checkpoint protein RAD17
name: DDB0233002
name: RAD17_HUMAN
xref: UnificationXref8912
feature: FragmentFeature1480
cellular location: GO_0005654
comment: Reactome DB_ID: 5583655
display name: RAD17

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref3487

UnificationXref6930
type: UnificationXref
id: MOD:00798
db: MOD

phospho-p-S216-CDC25C
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
xref: UnificationXref8884
feature: FragmentFeature1472
feature: ModificationFeature253
cellular location: GO_0005654
comment: Reactome DB_ID: 5581322

phospho-p-S216-CDC25C
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
xref: UnificationXref8886
feature: FragmentFeature1473
feature: ModificationFeature253
cellular location: GO_0005829
comment: Reactome DB_ID: 5581323

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233003
data source: Provenance1
name: DDB0233003
xref: UnificationXref8895
feature: FragmentFeature1474
cellular location: GO_0005654
comment: Reactome DB_ID: 5583670
display name: RAD1

RAD9
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8899
cellular location: GO_0005654
comment: Reactome DB_ID: 5583662
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233011
data source: Provenance1
name: DDB0233011
xref: UnificationXref8897
feature: FragmentFeature1475
cellular location: GO_0005654
comment: Reactome DB_ID: 5583660
display name: RAD9A

UnificationXref6939
type: UnificationXref
id: CHEBI:29034
db: ChEBI

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

UnificationXref6935
type: UnificationXref
id: 5582239
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582239

UnificationXref6936
type: UnificationXref
id: DDB0230075
db: UniProt

UnificationXref6937
type: UnificationXref
id: 5582246
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582246

UnificationXref6938
type: UnificationXref
id: 5582247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582247

UnificationXref2896
type: UnificationXref
id: 5584638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584638

UnificationXref2897
type: UnificationXref
id: 5584640
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584640

UnificationXref2894
type: UnificationXref
id: DDB0232174
db: UniProt

Stoichiometry2689
type: Stoichiometry
physical entity: Protein2445
stoichiometric coefficient: 1.0

UnificationXref2895
type: UnificationXref
id: 5584637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584637

Stoichiometry2688
type: Stoichiometry
physical entity: Protein2444
stoichiometric coefficient: 1.0

UnificationXref2892
type: UnificationXref
id: 5584633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584633

Stoichiometry2687
type: Stoichiometry
physical entity: Protein2443
stoichiometric coefficient: 1.0

UnificationXref2893
type: UnificationXref
id: REACT_246347
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246347.1

Stoichiometry2686
type: Stoichiometry
physical entity: SMC1 (BAA11495)
stoichiometric coefficient: 1.0

UnificationXref2890
type: UnificationXref
id: DDB0185283
db: UniProt

Stoichiometry2685
type: Stoichiometry
physical entity: Protein2442
stoichiometric coefficient: 1.0

UnificationXref2891
type: UnificationXref
id: 5584631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584631

Stoichiometry2684
type: Stoichiometry
physical entity: Protein2441
stoichiometric coefficient: 1.0

Stoichiometry2683
type: Stoichiometry
physical entity: Protein2440
stoichiometric coefficient: 1.0

Stoichiometry2682
type: Stoichiometry
physical entity: PhysicalEntity182
stoichiometric coefficient: 1.0

Stoichiometry2681
type: Stoichiometry
physical entity: PhysicalEntity181
stoichiometric coefficient: 1.0

Stoichiometry2680
type: Stoichiometry
physical entity: PhysicalEntity180
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/11851336
type: PublicationXref
id: 11851336
author: Swain, A
author: Dunten, P
author: Crowther, R
author: Kammlott, U
author: Wertheimer, SJ
author: Michel, H
author: Weber, D
author: Ramsey, GB
author: Levin, W
author: Belunis, C
author: Hollfelder, K
db: Pubmed
title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
source: J Mol Biol 316:257-264
year: 2002

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

UnificationXref2899
type: UnificationXref
id: 5592756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592756

UnificationXref2898
type: UnificationXref
id: REACT_253552
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253552.1

Stoichiometry2678
type: Stoichiometry
physical entity: PhysicalEntity179
stoichiometric coefficient: 1.0

Stoichiometry2677
type: Stoichiometry
physical entity: Protein2438
stoichiometric coefficient: 1.0

Stoichiometry2679
type: Stoichiometry
physical entity: Protein2439
stoichiometric coefficient: 1.0

Stoichiometry2674
type: Stoichiometry
physical entity: PhysicalEntity177
stoichiometric coefficient: 1.0

Stoichiometry2673
type: Stoichiometry
physical entity: Protein2436
stoichiometric coefficient: 1.0

Stoichiometry2676
type: Stoichiometry
physical entity: PhysicalEntity178
stoichiometric coefficient: 1.0

Stoichiometry2675
type: Stoichiometry
physical entity: Protein2437
stoichiometric coefficient: 1.0

Stoichiometry2670
type: Stoichiometry
physical entity: Protein2433
stoichiometric coefficient: 1.0

Stoichiometry2672
type: Stoichiometry
physical entity: Protein2435
stoichiometric coefficient: 1.0

Stoichiometry2671
type: Stoichiometry
physical entity: Protein2434
stoichiometric coefficient: 1.0

UnificationXref2870
type: UnificationXref
id: 196934
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196934

Stoichiometry2665
type: Stoichiometry
physical entity: Protein2429
stoichiometric coefficient: 4.0

UnificationXref2871
type: UnificationXref
id: REACT_11831
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11831.2

Stoichiometry2664
type: Stoichiometry
physical entity: Protein2428
stoichiometric coefficient: 1.0

Stoichiometry2663
type: Stoichiometry
physical entity: Protein2375
stoichiometric coefficient: 1.0

Stoichiometry2662
type: Stoichiometry
physical entity: Protein2427
stoichiometric coefficient: 1.0

UnificationXref2874
type: UnificationXref
id: 5584893
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584893

Stoichiometry2669
type: Stoichiometry
physical entity: Protein2432
stoichiometric coefficient: 1.0

UnificationXref2875
type: UnificationXref
id: 5584894
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584894

Stoichiometry2668
type: Stoichiometry
physical entity: Protein2431
stoichiometric coefficient: 1.0

UnificationXref2872
type: UnificationXref
id: DDB0302503
db: UniProt

Stoichiometry2667
type: Stoichiometry
physical entity: Complex995
stoichiometric coefficient: 1.0

UnificationXref2873
type: UnificationXref
id: 5584892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584892

Stoichiometry2666
type: Stoichiometry
physical entity: Protein2430
stoichiometric coefficient: 1.0

Stoichiometry2661
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

Stoichiometry2660
type: Stoichiometry
physical entity: Protein2426
stoichiometric coefficient: 1.0

UnificationXref2879
type: UnificationXref
id: 5584609
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584609

UnificationXref2878
type: UnificationXref
id: DDB0189361
db: UniProt

UnificationXref2877
type: UnificationXref
id: REACT_242979
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242979.1

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

UnificationXref2876
type: UnificationXref
id: 5584896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584896

(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMoleculeReference
name: acyl-GPI group
xref: UnificationXref13086

Stoichiometry2652
type: Stoichiometry
physical entity: Complex994
stoichiometric coefficient: 1.0

UnificationXref2880
type: UnificationXref
id: 5584610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584610

Stoichiometry2651
type: Stoichiometry
physical entity: Protein2421
stoichiometric coefficient: 1.0

UnificationXref2881
type: UnificationXref
id: 5584612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584612

Stoichiometry2654
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

UnificationXref2882
type: UnificationXref
id: REACT_256594
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256594.1

Stoichiometry2653
type: Stoichiometry
physical entity: Protein2422
stoichiometric coefficient: 1.0

UnificationXref2883
type: UnificationXref
id: 5592755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592755

Stoichiometry2656
type: Stoichiometry
physical entity: Complex992
stoichiometric coefficient: 1.0

UnificationXref2884
type: UnificationXref
id: REACT_226660
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226660.2

Stoichiometry2655
type: Stoichiometry
physical entity: Protein2423
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/7890667
type: PublicationXref
id: 7890667
author: Liu, SM
author: Cheng, HF
author: Wong, LP
author: King, K
author: Jiang, MJ
author: Chen, CL
author: Lomasney, JW
db: Pubmed
title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
source: J Biol Chem 270:5495-505
year: 1995

UnificationXref2885
type: UnificationXref
id: CHEBI:17621
db: ChEBI

Stoichiometry2658
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 3.0

UnificationXref2886
type: UnificationXref
id: 73524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524

Stoichiometry2657
type: Stoichiometry
physical entity: Protein2424
stoichiometric coefficient: 1.0

Stoichiometry2650
type: Stoichiometry
physical entity: Protein2420
stoichiometric coefficient: 1.0

phospho-p-S387-RFWD2
type: Protein
entity reference: UniProt:DDB0219336
data source: Provenance1
xref: UnificationXref8848
feature: ModificationFeature251
feature: FragmentFeature1467
cellular location: GO_0005829
comment: Reactome DB_ID: 5585520

phospho-p-S387-RFWD2
type: Protein
entity reference: UniProt:DDB0219336
data source: Provenance1
xref: UnificationXref8847
feature: FragmentFeature1466
feature: ModificationFeature251
cellular location: GO_0005654
comment: Reactome DB_ID: 5585519

phospho-p-S123-CDC25A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
xref: UnificationXref8866
feature: FragmentFeature1469
feature: ModificationFeature252
cellular location: GO_0005654
comment: Reactome DB_ID: 5578988

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
name: Cdc25A
name: Dual specificity phosphatase Cdc25A
name: M-phase inducer phosphatase 1
xref: UnificationXref8865
feature: FragmentFeature1468
cellular location: GO_0005654
comment: Reactome DB_ID: 5578972
display name: CDC25A

http://identifiers.org/pubmed/19073728
type: PublicationXref
id: 19073728
author: Lenschow, DJ
author: Virgin, HW
author: Giannakopoulos, NV
author: Lai, C
author: Haas, AL
author: Arutyunova, E
db: Pubmed
title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
source: J Virol 83:1602-10
year: 2009

DDB0191424
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
name: Cdc25C
name: Dual specificity phosphatase Cdc25C
name: M-phase inducer phosphatase 3
xref: UnificationXref8883
feature: FragmentFeature1471
cellular location: GO_0005654
comment: Reactome DB_ID: 5581320
display name: CDC25C

phospho-p-S123-CDC25A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191424
data source: Provenance1
xref: UnificationXref8871
feature: FragmentFeature1470
feature: ModificationFeature252
cellular location: GO_0005829
comment: Reactome DB_ID: 5578991

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref2888
type: UnificationXref
id: 29386
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

Stoichiometry2659
type: Stoichiometry
physical entity: Protein2425
stoichiometric coefficient: 1.0

UnificationXref2887
type: UnificationXref
id: REACT_3399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3399.2

UnificationXref2889
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267010
data source: Provenance1
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: DDB0267010
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref8830
feature: FragmentFeature1463
cellular location: GO_0005654
comment: Reactome DB_ID: 5581406
display name: CDK4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229294
data source: Provenance1
name: DDB0229294
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref8828
feature: FragmentFeature1462
cellular location: GO_0005654
comment: Reactome DB_ID: 5581402
display name: CDK4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235403
data source: Provenance1
name: PRMT5
name: DDB0235403
xref: UnificationXref8835
feature: FragmentFeature1465
cellular location: GO_0005654
comment: Reactome DB_ID: 5591691
display name: JBP1

dolichyl D-mannosyl phosphate [ChEBI:15809]
type: SmallMoleculeReference
name: Dolichyl phosphate D-mannose
name: dolichyl D-mannosyl phosphate
xref: UnificationXref13008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185035
data source: Provenance1
name: PRAD1 oncogene
name: BCL-1 oncogene
name: DDB0185035
name: G1/S-specific cyclin D1
xref: UnificationXref8833
feature: FragmentFeature1464
cellular location: GO_0005654
comment: Reactome DB_ID: 5581390
display name: CCND1

UniProt:DDB0231504
type: ProteinReference
xref: UnificationXref7399
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231505
type: ProteinReference
xref: UnificationXref3647
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231503
type: ProteinReference
xref: UnificationXref10384
organism: http://identifiers.org/taxonomy/44689

UnificationXref2853
type: UnificationXref
id: 198842
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198842

Stoichiometry2646
type: Stoichiometry
physical entity: Complex993
stoichiometric coefficient: 1.0

Signaling by GPCR
type: Pathway
data source: Provenance1
pathway component: REACT 261050.1
pathway component: REACT 211136.2
pathway component: REACT 205995.2
pathway component: REACT 223251.2
evidence: Evidence2266
xref: UnificationXref14404
xref: UnificationXref14403
pathway order: PathwayStep2210
pathway order: PathwayStep2227
pathway order: PathwayStep2226
pathway order: PathwayStep2190
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2852
type: UnificationXref
id: CHEBI:17627
db: ChEBI

Stoichiometry2647
type: Stoichiometry
physical entity: Protein2414
stoichiometric coefficient: 1.0

UnificationXref2851
type: UnificationXref
id: 5584803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584803

Stoichiometry2644
type: Stoichiometry
physical entity: Protein2416
stoichiometric coefficient: 1.0

UnificationXref2850
type: UnificationXref
id: DDB0304724
db: UniProt

Stoichiometry2645
type: Stoichiometry
physical entity: Protein2417
stoichiometric coefficient: 1.0

eNOS activation and regulation
type: Pathway
data source: Provenance1
pathway component: REACT 244391.1
pathway component: REACT 244773.1
pathway component: REACT 212091.2
evidence: Evidence920
xref: UnificationXref6288
xref: RelationshipXref830
xref: UnificationXref6289
pathway order: PathwayStep887
pathway order: PathwayStep899
pathway order: PathwayStep890
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2642
type: Stoichiometry
physical entity: Protein2414
stoichiometric coefficient: 1.0

Stoichiometry2643
type: Stoichiometry
physical entity: Protein2415
stoichiometric coefficient: 1.0

Stoichiometry2640
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

Stoichiometry2641
type: Stoichiometry
physical entity: Protein2413
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

UnificationXref2858
type: UnificationXref
id: REACT_11493
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11493.4

UnificationXref2859
type: UnificationXref
id: CHEBI:36144
db: ChEBI

UnificationXref2856
type: UnificationXref
id: CHEBI:16504
db: ChEBI

UnificationXref2857
type: UnificationXref
id: 198803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198803

UnificationXref2854
type: UnificationXref
id: REACT_11824
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11824.1

Stoichiometry2649
type: Stoichiometry
physical entity: Protein2419
stoichiometric coefficient: 1.0

UnificationXref2855
type: UnificationXref
id: 5584805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584805

Stoichiometry2648
type: Stoichiometry
physical entity: Protein2418
stoichiometric coefficient: 1.0

UniProt:DDB0231508
type: ProteinReference
xref: UnificationXref4979
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231507
type: ProteinReference
xref: UnificationXref4977
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231506
type: ProteinReference
xref: UnificationXref4975
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231513
type: ProteinReference
xref: UnificationXref2907
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231514
type: ProteinReference
xref: UnificationXref2921
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231515
type: ProteinReference
xref: UnificationXref2929
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231510
type: ProteinReference
xref: UnificationXref8958
organism: http://identifiers.org/taxonomy/44689

UnificationXref2862
type: UnificationXref
id: 5584804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584804

Stoichiometry2633
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

UnificationXref2861
type: UnificationXref
id: REACT_11277
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11277.2

Stoichiometry2634
type: Stoichiometry
physical entity: Protein2396
stoichiometric coefficient: 1.0

UnificationXref2864
type: UnificationXref
id: REACT_251410
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251410.1

Stoichiometry2635
type: Stoichiometry
physical entity: Protein2410
stoichiometric coefficient: 1.0

UnificationXref2863
type: UnificationXref
id: 5584807
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584807

Stoichiometry2636
type: Stoichiometry
physical entity: Protein2404
stoichiometric coefficient: 1.0

Stoichiometry2630
type: Stoichiometry
physical entity: Protein2407
stoichiometric coefficient: 1.0

UnificationXref2860
type: UnificationXref
id: 198853
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198853

Stoichiometry2631
type: Stoichiometry
physical entity: Protein2408
stoichiometric coefficient: 1.0

Stoichiometry2632
type: Stoichiometry
physical entity: Protein2409
stoichiometric coefficient: 1.0

UnificationXref2869
type: UnificationXref
id: REACT_11255
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11255.2

UnificationXref2865
type: UnificationXref
id: 5592781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592781

Stoichiometry2638
type: Stoichiometry
physical entity: Complex990
stoichiometric coefficient: 1.0

UnificationXref2866
type: UnificationXref
id: REACT_245313
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245313.1

Stoichiometry2637
type: Stoichiometry
physical entity: Protein2411
stoichiometric coefficient: 1.0

UnificationXref2867
type: UnificationXref
id: CHEBI:18385
db: ChEBI

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

UnificationXref2868
type: UnificationXref
id: 199622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=199622

Stoichiometry2639
type: Stoichiometry
physical entity: Protein2412
stoichiometric coefficient: 1.0

UniProt:DDB0231517
type: ProteinReference
xref: UnificationXref2937
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

SequenceSite4799
type: SequenceSite
position status: EQUAL
sequence position: 375

Stoichiometry2620
type: Stoichiometry
physical entity: Protein2403
stoichiometric coefficient: 1.0

Stoichiometry2621
type: Stoichiometry
physical entity: Complex989
stoichiometric coefficient: 1.0

UnificationXref2831
type: UnificationXref
id: 5584799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584799

Stoichiometry2624
type: Stoichiometry
physical entity: Protein2404
stoichiometric coefficient: 1.0

UnificationXref2830
type: UnificationXref
id: 5584797
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584797

Stoichiometry2625
type: Stoichiometry
physical entity: Complex988
stoichiometric coefficient: 1.0

Stoichiometry2622
type: Stoichiometry
physical entity: Protein2395
stoichiometric coefficient: 1.0

Stoichiometry2623
type: Stoichiometry
physical entity: Protein2396
stoichiometric coefficient: 1.0

UnificationXref6992
type: UnificationXref
id: DDB0231410
db: UniProt

UnificationXref2834
type: UnificationXref
id: 74113
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113

Stoichiometry2629
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

UnificationXref6991
type: UnificationXref
id: REACT_253066
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253066.1

UnificationXref2835
type: UnificationXref
id: REACT_4155
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4155.2

Stoichiometry2628
type: Stoichiometry
physical entity: Protein2406
stoichiometric coefficient: 1.0

UnificationXref6990
type: UnificationXref
id: 5582259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582259

UnificationXref2832
type: UnificationXref
id: REACT_234301
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234301.1

Stoichiometry2627
type: Stoichiometry
physical entity: Protein2405
stoichiometric coefficient: 1.0

UnificationXref2833
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Stoichiometry2626
type: Stoichiometry
physical entity: Complex986
stoichiometric coefficient: 1.0

UnificationXref2838
type: UnificationXref
id: REACT_11860
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11860.2

UnificationXref2839
type: UnificationXref
id: 83910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910

UnificationXref2836
type: UnificationXref
id: CHEBI:29073
db: ChEBI

UnificationXref2837
type: UnificationXref
id: 198836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198836

UnificationXref6999
type: UnificationXref
id: 5582276
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582276

UnificationXref6998
type: UnificationXref
id: REACT_180185
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_180185.3

UnificationXref6997
type: UnificationXref
id: 5582277
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582277

UnificationXref6996
type: UnificationXref
id: REACT_260455
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260455.1

UnificationXref6995
type: UnificationXref
id: 5579816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579816

UnificationXref6994
type: UnificationXref
id: 5579814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579814

UnificationXref6993
type: UnificationXref
id: 5579813
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579813

SequenceSite4789
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite4788
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2610
type: Stoichiometry
physical entity: Protein2395
stoichiometric coefficient: 1.0

UnificationXref2840
type: UnificationXref
id: REACT_3923
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3923.2

Stoichiometry2611
type: Stoichiometry
physical entity: Protein2396
stoichiometric coefficient: 1.0

Stoichiometry2612
type: Stoichiometry
physical entity: Complex987
stoichiometric coefficient: 1.0

UnificationXref2842
type: UnificationXref
id: REACT_11772
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11772.3

Stoichiometry2613
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

UnificationXref2841
type: UnificationXref
id: 198816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198816

Stoichiometry2614
type: Stoichiometry
physical entity: Protein2397
stoichiometric coefficient: 1.0

UnificationXref2843
type: UnificationXref
id: DDB0304704
db: UniProt

Stoichiometry2616
type: Stoichiometry
physical entity: Protein2399
stoichiometric coefficient: 1.0

UnificationXref2844
type: UnificationXref
id: 5584811
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584811

Stoichiometry2615
type: Stoichiometry
physical entity: Protein2398
stoichiometric coefficient: 1.0

UnificationXref2845
type: UnificationXref
id: DDB0304705
db: UniProt

Stoichiometry2618
type: Stoichiometry
physical entity: Protein2401
stoichiometric coefficient: 1.0

UnificationXref2846
type: UnificationXref
id: 5584815
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584815

Stoichiometry2617
type: Stoichiometry
physical entity: Protein2400
stoichiometric coefficient: 1.0

SequenceSite4790
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2847
type: UnificationXref
id: 5584816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584816

UnificationXref2848
type: UnificationXref
id: 5584818
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584818

Stoichiometry2619
type: Stoichiometry
physical entity: Protein2402
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

UnificationXref2849
type: UnificationXref
id: REACT_253565
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253565.1

SequenceSite4795
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4796
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4797
type: SequenceSite
position status: EQUAL
sequence position: 375

SequenceSite4798
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4791
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4792
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4793
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4794
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4781
type: SequenceSite
position status: EQUAL
sequence position: 281

SequenceSite4780
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4783
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite4782
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4785
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite4784
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4787
type: SequenceSite
position status: EQUAL
sequence position: 129

SequenceSite4786
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0304576
type: ProteinReference
xref: UnificationXref3077
organism: http://identifiers.org/taxonomy/44689

SequenceSite4777
type: SequenceSite
position status: EQUAL
sequence position: 858

SequenceSite4778
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4779
type: SequenceSite
position status: EQUAL
sequence position: 225

SequenceSite4772
type: SequenceSite
position status: EQUAL
sequence position: 715

SequenceSite4771
type: SequenceSite
position status: EQUAL
sequence position: 858

SequenceSite4770
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4776
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4775
type: SequenceSite
position status: EQUAL
sequence position: 715

SequenceSite4774
type: SequenceSite
position status: EQUAL
sequence position: 858

SequenceSite4773
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UniProt:DDB0304567
type: ProteinReference
xref: UnificationXref4340
organism: http://identifiers.org/taxonomy/44689

SequenceSite4768
type: SequenceSite
position status: EQUAL
sequence position: 169

SequenceSite4769
type: SequenceSite
position status: EQUAL
sequence position: 715

SequenceSite4766
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite4767
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4763
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4762
type: SequenceSite
position status: EQUAL
sequence position: 180

SequenceSite4765
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4764
type: SequenceSite
position status: EQUAL
sequence position: 192

SequenceSite4761
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4760
type: SequenceSite
position status: EQUAL
sequence position: 631

SequenceSite4759
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite4755
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4756
type: SequenceSite
position status: EQUAL
sequence position: 185

SequenceSite4757
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4758
type: SequenceSite
position status: EQUAL
sequence position: 286

SequenceSite4754
type: SequenceSite
position status: EQUAL
sequence position: 183

SequenceSite4753
type: SequenceSite
position status: EQUAL
sequence position: 18

SequenceSite4752
type: SequenceSite
position status: EQUAL
sequence position: 456

SequenceSite4751
type: SequenceSite
position status: EQUAL
sequence position: 43

SequenceSite4750
type: SequenceSite
position status: EQUAL
sequence position: 68

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

SequenceSite4748
type: SequenceSite
position status: EQUAL
sequence position: 96

SequenceSite4749
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4746
type: SequenceSite
position status: EQUAL
sequence position: 476

SequenceSite4747
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4744
type: SequenceSite
position status: EQUAL
sequence position: 607

SequenceSite4745
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4740
type: SequenceSite
position status: EQUAL
sequence position: 638

SequenceSite4741
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/19603532
type: PublicationXref
id: 19603532
author: Dubourg, Christèle
author: Solomon, Benjamin D
author: Pineda-Alvarez, Daniel E
author: Bendavid, Claude
author: Zhou, Nan
author: Muenke, Maximilian
author: Ouspenskaia, Maia
author: Hehr, Ute
author: Lacbawan, Felicitas
author: El-Jaick, Kenia B
author: Smeets, Hubert J
author: David, Véronique
author: Bale, Sherri
author: Vélez, Jorge I
author: Odent, Sylvie
author: Roessler, Erich
author: Paulussen, Aimée
db: Pubmed
title: The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
source: Hum. Mutat. 30:E921-35
year: 2009

SequenceSite4742
type: SequenceSite
position status: EQUAL
sequence position: 271

SequenceSite4743
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite4734
type: SequenceSite
position status: EQUAL
sequence position: 86

SequenceSite4733
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4736
type: SequenceSite
position status: EQUAL
sequence position: 627

SequenceSite4735
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4738
type: SequenceSite
position status: EQUAL
sequence position: 671

SequenceSite4737
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4739
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

SequenceSite4731
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4732
type: SequenceSite
position status: EQUAL
sequence position: 136

SequenceSite4730
type: SequenceSite
position status: EQUAL
sequence position: 136

SequenceSite4725
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4724
type: SequenceSite
position status: EQUAL
sequence position: 721

SequenceSite4723
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4722
type: SequenceSite
position status: EQUAL
sequence position: 351

SequenceSite4729
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4728
type: SequenceSite
position status: EQUAL
sequence position: 504

SequenceSite4727
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4726
type: SequenceSite
position status: EQUAL
sequence position: 523

UniProt:DDB0304520
type: ProteinReference
xref: UnificationXref1919
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0304521
type: ProteinReference
xref: UnificationXref1915
organism: http://identifiers.org/taxonomy/44689

SequenceSite4720
type: SequenceSite
position status: EQUAL
sequence position: 305

SequenceSite4721
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4716
type: SequenceSite
position status: EQUAL
sequence position: 1220

SequenceSite4715
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0304516
type: ProteinReference
xref: UnificationXref1917
organism: http://identifiers.org/taxonomy/44689

SequenceSite4718
type: SequenceSite
position status: EQUAL
sequence position: 452

UniProt:DDB0304517
type: ProteinReference
xref: UnificationXref1913
organism: http://identifiers.org/taxonomy/44689

SequenceSite4717
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4712
type: SequenceSite
position status: EQUAL
sequence position: 118

SequenceSite4711
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4714
type: SequenceSite
position status: EQUAL
sequence position: 431

SequenceSite4713
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4719
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0266878
type: ProteinReference
xref: UnificationXref2173
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/21413788
type: PublicationXref
id: 21413788
author: Dunaway-Mariano, Debra
author: Wu, Rui
author: Garland, Megan
author: Allen, Karen N
db: Pubmed
title: Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1
source: Biochemistry 50:3045-7
year: 2011

UniProt:DDB0266876
type: ProteinReference
xref: UnificationXref13605
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266877
type: ProteinReference
xref: UnificationXref2169
organism: http://identifiers.org/taxonomy/44689

SequenceSite4710
type: SequenceSite
position status: EQUAL
sequence position: 326

SequenceSite4707
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry2690
type: Stoichiometry
physical entity: Protein2446
stoichiometric coefficient: 1.0

SequenceSite4706
type: SequenceSite
position status: EQUAL
sequence position: 318

SequenceSite4705
type: SequenceSite
position status: EQUAL
sequence position: 326

SequenceSite4704
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry2693
type: Stoichiometry
physical entity: Complex871
stoichiometric coefficient: 1.0

SequenceSite4703
type: SequenceSite
position status: EQUAL
sequence position: 221

Stoichiometry2694
type: Stoichiometry
physical entity: PhysicalEntity183
stoichiometric coefficient: 1.0

SequenceSite4702
type: SequenceSite
position status: EQUAL
sequence position: 158

Stoichiometry2691
type: Stoichiometry
physical entity: Protein2447
stoichiometric coefficient: 1.0

SequenceSite4701
type: SequenceSite
position status: EQUAL
sequence position: 898

Stoichiometry2692
type: Stoichiometry
physical entity: Protein2448
stoichiometric coefficient: 1.0

SequenceSite4700
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2697
type: Stoichiometry
physical entity: PhysicalEntity184
stoichiometric coefficient: 1.0

Stoichiometry2698
type: Stoichiometry
physical entity: Protein2449
stoichiometric coefficient: 1.0

Stoichiometry2695
type: Stoichiometry
physical entity: Complex878
stoichiometric coefficient: 1.0

Stoichiometry2696
type: Stoichiometry
physical entity: Complex997
stoichiometric coefficient: 1.0

Stoichiometry2699
type: Stoichiometry
physical entity: Protein2452
stoichiometric coefficient: 1.0

SequenceSite4709
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4708
type: SequenceSite
position status: EQUAL
sequence position: 326

Biosynthesis of A2E, implicated in retinal degradation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction137
evidence: Evidence273
xref: UnificationXref2154
xref: UnificationXref2155
pathway order: PathwayStep255
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

Synthesis of PIPs at the early endosome membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction515
pathway component: BiochemicalReaction518
pathway component: BiochemicalReaction519
pathway component: BiochemicalReaction516
pathway component: BiochemicalReaction517
pathway component: BiochemicalReaction520
evidence: Evidence793
xref: RelationshipXref658
xref: UnificationXref5573
xref: UnificationXref5574
pathway order: PathwayStep768
pathway order: PathwayStep770
pathway order: PathwayStep769
pathway order: PathwayStep771
pathway order: PathwayStep767
pathway order: PathwayStep772
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305115
data source: Provenance1
name: DDB0305115
xref: UnificationXref8753
feature: FragmentFeature1444
cellular location: GO_0005654
comment: Reactome DB_ID: 5578587
display name: CDC6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216397
data source: Provenance1
name: Retinoblastoma binding protein 3
name: RBBP-3
name: PBR3
name: Retinoblastoma-associated protein 1
name: PRB-binding protein E2F-1
name: DDB0216397
name: Transcription factor E2F1
name: RBAP-1
name: E2F-1
xref: UnificationXref8758
feature: FragmentFeature1445
cellular location: GO_0005654
comment: Reactome DB_ID: 5578591
display name: E2F1

http://identifiers.org/pubmed/10681536
type: PublicationXref
id: 10681536
author: Gaither, LA
author: Eide, DJ
db: Pubmed
title: Functional expression of the human hZIP2 zinc transporter
source: J Biol Chem 275:5560-4
year: 2000

Activating E2F transcription factors
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
name: Cell cycle promoting E2Fs
xref: UnificationXref8760
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5578593
display name: E2F1/2/3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232357
data source: Provenance1
name: DDB0232357
name: DNA replication licensing factor MCM6
name: P105MCM
name: Mcm6
xref: UnificationXref8768
feature: FragmentFeature1447
cellular location: GO_0005654
comment: Reactome DB_ID: 5578621
display name: MCM6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216397
data source: Provenance1
name: DDB0216397
name: E2F-3
name: Transcription factor E2F3
xref: UnificationXref8759
feature: FragmentFeature1446
cellular location: GO_0005654
comment: Reactome DB_ID: 5578592
display name: E2F3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232349
data source: Provenance1
name: Mcm7
name: P1.1-MCM3
name: DNA replication licensing factor MCM7
name: CDC47 homolog
name: DDB0232349
xref: UnificationXref8770
feature: FragmentFeature1448
cellular location: GO_0005654
comment: Reactome DB_ID: 5578625
display name: MCM7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232356
data source: Provenance1
name: P1-CDC21
name: DDB0232356
name: DNA replication licensing factor MCM4
name: Mcm4
name: CDC21 homolog
xref: UnificationXref8772
feature: FragmentFeature1449
cellular location: GO_0005654
comment: Reactome DB_ID: 5578613
display name: MCM4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232348
data source: Provenance1
name: P1-MCM3
name: DNA polymerase alpha holoenzyme-associated protein P1
name: RLF beta subunit
name: P102 protein
name: DNA replication licensing factor MCM3
name: Mcm3
name: DDB0232348
xref: UnificationXref8774
feature: FragmentFeature1450
cellular location: GO_0005654
comment: Reactome DB_ID: 5578609
display name: MCM3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232353
data source: Provenance1
name: Nuclear protein BM28
name: DNA replication licensing factor MCM2
name: DDB0232353
name: Mcm2
xref: UnificationXref8776
feature: FragmentFeature1451
cellular location: GO_0005654
comment: Reactome DB_ID: 5578629
display name: MCM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232354
data source: Provenance1
name: CDC46 homolog
name: P1-CDC46
name: DNA replication licensing factor MCM5
name: DDB0232354
name: Mcm5
xref: UnificationXref8778
feature: FragmentFeature1452
cellular location: GO_0005654
comment: Reactome DB_ID: 5578617
display name: MCM5

http://identifiers.org/pubmed/18367721
type: PublicationXref
id: 18367721
author: Skinner, SJ
author: Deleault, KM
author: Whitfield, ML
author: Brooks, SA
author: Gross, RH
author: Townley-Tilson, WH
author: Emmons, J
db: Pubmed
title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
source: RNA 14:888-902
year: 2008

http://identifiers.org/pubmed/12782243
type: PublicationXref
id: 12782243
author: Prézeau, L
author: Galvez, T
author: Pin, JP
db: Pubmed
title: Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
source: Pharmacol Ther 98:325-54
year: 2003

phospho-p-S274,S326-NUDC
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266415
data source: Provenance1
xref: UnificationXref8711
feature: FragmentFeature1437
feature: ModificationFeature249
feature: ModificationFeature250
cellular location: GO_0005654
comment: Reactome DB_ID: 5582793

DDB0266415
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266415
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8710
feature: FragmentFeature1436
cellular location: GO_0005654
comment: Reactome DB_ID: 5582790
display name: NUDC

phospho-p-S528-KIF20A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201555
data source: Provenance1
xref: UnificationXref8706
feature: ModificationFeature248
feature: FragmentFeature1435
cellular location: GO_0005654
comment: Reactome DB_ID: 5582800

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201555
data source: Provenance1
name: DDB0201555
name: KIF20A
xref: UnificationXref8705
feature: FragmentFeature1434
cellular location: GO_0005654
comment: Reactome DB_ID: 5582798
display name: MKLP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233112
data source: Provenance1
name: Orc5
name: DDB0233112
name: Origin recognition complex subunit 5
xref: UnificationXref8729
feature: FragmentFeature1440
cellular location: GO_0005654
comment: Reactome DB_ID: 5578569
display name: ORC5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233111
data source: Provenance1
name: Orc4
name: DDB0233111
name: Origin recognition complex subunit 4
xref: UnificationXref8734
feature: FragmentFeature1441
cellular location: GO_0005654
comment: Reactome DB_ID: 5578575
display name: ORC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233773
data source: Provenance1
name: DDB0233773
name: Origin recognition complex subunit Latheo
name: Origin recognition complex subunit 3
name: Orc3
xref: UnificationXref8719
feature: FragmentFeature1438
cellular location: GO_0005654
comment: Reactome DB_ID: 5578558
display name: ORC3

DDB0231726
type: Protein
entity reference: UniProt:DDB0231726
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Origin recognition complex subunit 2
name: Orc2
xref: UnificationXref8721
feature: FragmentFeature1439
cellular location: GO_0005654
comment: Reactome DB_ID: 5578562
display name: ORC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233110
data source: Provenance1
name: Origin recognition complex subunit 1
name: Replication control protein 1
name: DDB0233110
name: Orc1
xref: UnificationXref8739
feature: FragmentFeature1442
cellular location: GO_0005654
comment: Reactome DB_ID: 5578581
display name: ORC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232350
data source: Provenance1
name: DNA helicase MCM8
name: MCM8_HUMAN
name: DDB0232350
xref: UnificationXref8747
feature: FragmentFeature1443
cellular location: GO_0005654
comment: Reactome DB_ID: 5578600
display name: MCM8

Iron uptake and transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1027
pathway component: REACT 220258.2
pathway component: BiochemicalReaction1012
evidence: Evidence1559
xref: RelationshipXref1402
xref: UnificationXref10258
xref: UnificationXref10257
pathway order: PathwayStep1527
pathway order: PathwayStep1530
pathway order: PathwayStep1501
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0304592
type: ProteinReference
xref: UnificationXref13717
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0266806
type: ProteinReference
xref: UnificationXref13126
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216320
data source: Provenance1
name: DNA polymerase II subunit A
name: DDB0216320
name: DNA polymerase epsilon, catalytic subunit A
xref: UnificationXref8805
feature: FragmentFeature1458
cellular location: GO_0005654
comment: Reactome DB_ID: 5578649
display name: POLE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232274
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: DDB0232274
name: POLA1
xref: UnificationXref8802
feature: FragmentFeature1457
cellular location: GO_0005654
comment: Reactome DB_ID: 5578636
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304676
data source: Provenance1
name: DNA polymerase alpha 70 kDa subunit
name: DNA polymerase subunit B
name: POLA2
name: DDB0304676
xref: UnificationXref8800
feature: FragmentFeature1456
cellular location: GO_0005654
comment: Reactome DB_ID: 5578640
display name: p70

PRIM1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232279
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0232279
name: DNA primase small subunit
name: DNA primase 49 kDa subunit
xref: UnificationXref8798
feature: FragmentFeature1455
cellular location: GO_0005654
comment: Reactome DB_ID: 5578644
display name: p49

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237549
data source: Provenance1
name: DDB0237549
name: Cdc45
name: CDC45-related protein
name: PORC-PI-1
xref: UnificationXref8793
feature: FragmentFeature1454
cellular location: GO_0005654
comment: Reactome DB_ID: 5578665
display name: CDC45

Cdc7
type: Protein
entity reference: UniProt:DDB0231210
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: huCdc7
name: HsCdc7
name: Cell division cycle 7-related protein kinase
name: CDC7- related kinase
name: DDB0231210
name: Cell division protein kinase 7
name: Cell division cycle 7-related protein kinase (EC 2.7.1.-) (CDC7- related kinase) (HsCdc7) (huCdc7)
xref: UnificationXref8788
feature: FragmentFeature1453
cellular location: GO_0005654
comment: Reactome DB_ID: 5578674
display name: CDC7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229424
data source: Provenance1
name: DDB0229424
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref8824
feature: FragmentFeature1460
cellular location: GO_0005654
comment: Reactome DB_ID: 5581394
display name: CDK4

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230050
data source: Provenance1
name: DDB0230050
name: Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4)
name: Cyclin-dependent kinase 4
name: Cdk4
name: PSK-J3
name: Cell division protein kinase 4
xref: UnificationXref8826
feature: FragmentFeature1461
cellular location: GO_0005654
comment: Reactome DB_ID: 5581398
display name: CDK4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216321
data source: Provenance1
name: DDB0216321
name: DNA polymerase II subunit B
name: DNA polymerase epsilon subunit B
xref: UnificationXref8807
feature: FragmentFeature1459
cellular location: GO_0005654
comment: Reactome DB_ID: 5578653
display name: POLE2

Homologues of CDK4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8831
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581407

UnificationXref2829
type: UnificationXref
id: REACT_11982
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11982.3

DDB0305112
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305112
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sister chromatid cohesion protein PDS5 homolog B
name: PDS5B
name: APRIN
xref: UnificationXref8631
feature: FragmentFeature1413
cellular location: GO_0005694
comment: Reactome DB_ID: 5591128
display name: AS3

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

UnificationXref2824
type: UnificationXref
id: REACT_202527
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202527.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238657
data source: Provenance1
name: DDB0238657
name: STAG1
xref: UnificationXref8624
feature: FragmentFeature1409
cellular location: GO_0005694
comment: Reactome DB_ID: 5591117
display name: SA1

UnificationXref2823
type: UnificationXref
id: 5592293
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592293

DDB0305113
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305113
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: RAD21
name: Double-strand-break repair protein rad21 homolog
name: SCC1 homolog
xref: UnificationXref8622
feature: FragmentFeature1408
cellular location: GO_0005694
comment: Reactome DB_ID: 5591116
display name: NXP1

UnificationXref2822
type: UnificationXref
id: REACT_215174
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215174.2

2xAcK-SMC3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219934
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0219934
xref: UnificationXref8620
feature: FragmentFeature1407
feature: ModificationFeature239
feature: ModificationFeature238
cellular location: GO_0005694
comment: Reactome DB_ID: 5591122
display name: Ac-SMC3

UnificationXref2821
type: UnificationXref
id: 5592292
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592292

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168507
data source: Provenance1
name: DDB0168507
name: lipin 1
xref: UnificationXref8606
feature: FragmentFeature1406
cellular location: GO_0005635
comment: Reactome DB_ID: 5592065
display name: LPIN1

UnificationXref2828
type: UnificationXref
id: 198827
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198827

DDB0305112
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305112
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sister chromatid cohesion protein PDS5 homolog A
name: PDS5A
xref: UnificationXref8630
feature: FragmentFeature1412
cellular location: GO_0005694
comment: Reactome DB_ID: 5591127
display name: PDS5

UnificationXref2827
type: UnificationXref
id: REACT_11802
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11802.2

PDS5A/PDS5B
type: Protein
data source: Provenance1
member physical entity: DDB0305112
name: PDS5A/B
xref: UnificationXref8632
cellular location: GO_0005694
comment: Reactome DB_ID: 5591129
comment: Converted from EntitySet in Reactome
display name: PDS5

UnificationXref2826
type: UnificationXref
id: 198852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198852

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219931
data source: Provenance1
name: Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (SB1.8/DXS423E protein) (Sb1.8)
name: Structural maintenance of chromosome 1-like 1 protein
name: DDB0219931
name: SB1.8/DXS423E protein
name: Sb1.8
name: SMC1alpha protein
xref: UnificationXref8627
feature: FragmentFeature1411
cellular location: GO_0005694
comment: Reactome DB_ID: 5591119
display name: SMC1A

UnificationXref2825
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238657
data source: Provenance1
name: DDB0238657
name: STAG2
xref: UnificationXref8625
feature: FragmentFeature1410
cellular location: GO_0005694
comment: Reactome DB_ID: 5591118
display name: SA2

UnificationXref2820
type: UnificationXref
id: REACT_251425
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251425.1

LPIN
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8607
cellular location: GO_0005635
comment: Reactome DB_ID: 5592066
comment: Converted from EntitySet in Reactome

UnificationXref2819
type: UnificationXref
id: 5592290
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592290

phospho-p-T1415,S1419-NCAPD3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304963
data source: Provenance1
xref: UnificationXref8595
feature: ModificationFeature234
feature: ModificationFeature237
feature: FragmentFeature1405
cellular location: GO_0005654
comment: Reactome DB_ID: 5590990

UnificationXref2818
type: UnificationXref
id: REACT_249333
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249333.1

phospho-p-S-NCAPG2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188128
data source: Provenance1
xref: UnificationXref8594
feature: ModificationFeature236
feature: FragmentFeature1404
cellular location: GO_0005654
comment: Reactome DB_ID: 5590992

UnificationXref2811
type: UnificationXref
id: 5582203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582203

hCAP-H2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184121
data source: Provenance1
name: Condensin-2 complex subunit H2
name: Note: the coordinates are copied over from Homo sapiens.
name: Non-SMC condensin II complex subunit H2
name: Chromosome-associated protein H2
name: DDB0184121
name: Kleisin-beta
name: NCAPH2
xref: UnificationXref8574
feature: FragmentFeature1397
cellular location: GO_0005654
comment: Reactome DB_ID: 5590903
display name: CAPH2

Stoichiometry2604
type: Stoichiometry
physical entity: PhysicalEntity175
stoichiometric coefficient: 1.0

UnificationXref2810
type: UnificationXref
id: 5582204
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582204

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219935
data source: Provenance1
name: CAPC
name: hCAP-C
name: SMC4L1
name: Structural maintenance of chromosomes protein 4
name: XCAP-C homolog
name: Chromosome-associated polypeptide C
name: DDB0219935
name: SMC-4
name: SMC protein 4
xref: UnificationXref8572
feature: FragmentFeature1396
cellular location: GO_0005654
comment: Reactome DB_ID: 5590891
display name: SMC4

Stoichiometry2605
type: Stoichiometry
physical entity: Complex898
stoichiometric coefficient: 1.0

UnificationXref2813
type: UnificationXref
id: REACT_258052
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258052.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219933
data source: Provenance1
name: SMC2L1
name: CAPE
name: SMC-2
name: Chromosome-associated protein E
name: SMC protein 2
name: PRO0324
name: XCAP-E homolog
name: Structural maintenance of chromosomes protein 2
name: DDB0219933
xref: UnificationXref8578
feature: FragmentFeature1399
cellular location: GO_0005654
comment: Reactome DB_ID: 5590887
display name: SMC2

Stoichiometry2606
type: Stoichiometry
physical entity: PhysicalEntity8
stoichiometric coefficient: 1.0

UnificationXref2812
type: UnificationXref
id: 5582205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582205

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304963
data source: Provenance1
name: Non-SMC condensin II complex subunit D3
name: Condensin-2 complex subunit D3
name: KIAA0056
name: DDB0304963
name: NCAPD3
xref: UnificationXref8576
feature: FragmentFeature1398
cellular location: GO_0005654
comment: Reactome DB_ID: 5590895
display name: CAPD3

Stoichiometry2607
type: Stoichiometry
physical entity: PhysicalEntity176
stoichiometric coefficient: 1.0

UnificationXref2815
type: UnificationXref
id: 5580749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580749

phospho-p-T1415-NCAPD3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304963
data source: Provenance1
xref: UnificationXref8586
feature: FragmentFeature1401
feature: ModificationFeature234
cellular location: GO_0005654
comment: Reactome DB_ID: 5590986

Stoichiometry2608
type: Stoichiometry
physical entity: Complex898
stoichiometric coefficient: 1.0

UnificationXref2814
type: UnificationXref
id: 5580747
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580747

DDB0188128
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188128
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Non-SMC condensin II complex subunit G2
name: Condensin-2 complex subunit G2
name: CAP-G2
name: hCAP-G2
name: NCAPG2
name: Chromosome-associated protein G2
name: Leucine zipper protein 5
xref: UnificationXref8580
feature: FragmentFeature1400
cellular location: GO_0005654
comment: Reactome DB_ID: 5590899
display name: LUZP5

Stoichiometry2609
type: Stoichiometry
physical entity: PhysicalEntity1
stoichiometric coefficient: 1.0

UnificationXref2817
type: UnificationXref
id: 5592377
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592377

phospho-p-S-NCAPH2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184121
data source: Provenance1
xref: UnificationXref8593
feature: FragmentFeature1403
feature: ModificationFeature235
cellular location: GO_0005654
comment: Reactome DB_ID: 5590994

UnificationXref2816
type: UnificationXref
id: REACT_203016
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203016.2

DDB0216332
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216332
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8589
feature: FragmentFeature1402
cellular location: GO_0005654
comment: Reactome DB_ID: 5582781
display name: PLK1

Stoichiometry2601
type: Stoichiometry
physical entity: Complex898
stoichiometric coefficient: 1.0

Stoichiometry2600
type: Stoichiometry
physical entity: Guanosine monophosphate
stoichiometric coefficient: 1.0

UniProt:DDB0231541
type: ProteinReference
xref: UnificationXref6060
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2603
type: Stoichiometry
physical entity: PhysicalEntity8
stoichiometric coefficient: 1.0

Stoichiometry2602
type: Stoichiometry
physical entity: Complex982
stoichiometric coefficient: 1.0

UnificationXref2809
type: UnificationXref
id: 5580746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580746

UnificationXref2808
type: UnificationXref
id: 5580745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580745

UnificationXref2807
type: UnificationXref
id: 5580744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580744

UnificationXref2806
type: UnificationXref
id: DDB0237882
db: UniProt

UnificationXref2805
type: UnificationXref
id: 5580740
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580740

phospho-p-S904,S905-KIF23
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201555
data source: Provenance1
xref: UnificationXref8702
feature: ModificationFeature247
feature: FragmentFeature1433
feature: ModificationFeature246
cellular location: GO_0005654
comment: Reactome DB_ID: 5582777

UnificationXref2804
type: UnificationXref
id: DDB0237884
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201555
data source: Provenance1
name: Kinesin-like protein KIF23
name: MKLP1
name: DDB0201555
xref: UnificationXref8701
feature: FragmentFeature1432
cellular location: GO_0005654
comment: Reactome DB_ID: 5582774
display name: KIF23

UnificationXref2803
type: UnificationXref
id: 5580736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580736

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188839
data source: Provenance1
name: Separin middle fragment
name: ESPL1(1507-1535)
name: Separase middle fragment
name: ESPL1 middle fragment
xref: UnificationXref8690
feature: FragmentFeature1431
cellular location: GO_0005829
comment: Reactome DB_ID: 5591162
display name: DDB0188839

UnificationXref2802
type: UnificationXref
id: DDB0237883
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188839
data source: Provenance1
name: Separin N-terminus
name: Separase N-terminus
name: ESPL1 N-terminus
name: ESPL1(1-1506)
xref: UnificationXref8689
feature: FragmentFeature1430
cellular location: GO_0005829
comment: Reactome DB_ID: 5591161
display name: DDB0188839

UnificationXref2801
type: UnificationXref
id: REACT_3275
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3275.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188839
data source: Provenance1
name: ESPL1 C-terminus
name: Separase C-terminus
name: Separin C-terminus
name: ESPL1(1536-2120)
xref: UnificationXref8688
feature: FragmentFeature1429
cellular location: GO_0005829
comment: Reactome DB_ID: 5591160
display name: DDB0188839

UnificationXref2800
type: UnificationXref
id: 109386
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109386

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188839
data source: Provenance1
name: Separase
name: Caspase-like protein ESPL1
name: Separin
name: ESPL1
name: DDB0188839
name: Extra spindle poles-like 1 protein
name: KIAA0165
xref: UnificationXref8687
feature: FragmentFeature1428
cellular location: GO_0005829
comment: Reactome DB_ID: 5591159
display name: ESP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216346
data source: Provenance1
name: DDB0216346
name: Casein kinase II beta subunit
xref: UnificationXref8668
feature: FragmentFeature1427
cellular location: GO_0005829
comment: Reactome DB_ID: 5591283
display name: CSNK2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185025
data source: Provenance1
name: DDB0185025
name: Casein kinase alpha subunit
xref: UnificationXref8661
feature: FragmentFeature1425
cellular location: GO_0005829
comment: Reactome DB_ID: 5591287
display name: CSNK2A1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185025
data source: Provenance1
name: DDB0185025
name: Casein kinase alpha' subunit
xref: UnificationXref8663
feature: FragmentFeature1426
cellular location: GO_0005829
comment: Reactome DB_ID: 5591289
display name: CSNK2A2

phospho-p-S-NCAPD2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304964
data source: Provenance1
xref: UnificationXref8658
feature: FragmentFeature1424
feature: ModificationFeature245
cellular location: GO_0005829
comment: Reactome DB_ID: 5591270

UniProt:DDB0231531
type: ProteinReference
xref: UnificationXref9679
organism: http://identifiers.org/taxonomy/44689

DNA Damage Recognition in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1105
pathway component: BiochemicalReaction1104
evidence: Evidence1699
xref: UnificationXref10898
xref: RelationshipXref1466
xref: UnificationXref10899
pathway order: PathwayStep1666
pathway order: PathwayStep1665
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

phospho-p-S-SMC4
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219935
data source: Provenance1
xref: UnificationXref8655
feature: FragmentFeature1421
feature: ModificationFeature242
cellular location: GO_0005829
comment: Reactome DB_ID: 5591276

http://identifiers.org/pubmed/1400883
type: PublicationXref
id: 1400883
author: Larsen, PR
author: Kieffer, JD
author: Berry, MJ
author: Harney, JW
author: Warne, RL
author: Mandel, SJ
db: Pubmed
title: Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase
source: J Clin Endocrinol Metab 75:1133-9
year: 1992

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219935
data source: Provenance1
name: CAPC
name: hCAP-C
name: SMC4L1
name: Structural maintenance of chromosomes protein 4
name: XCAP-C homolog
name: Chromosome-associated polypeptide C
name: DDB0219935
name: SMC-4
name: SMC protein 4
xref: UnificationXref8653
feature: FragmentFeature1420
cellular location: GO_0005829
comment: Reactome DB_ID: 5591257
display name: SMC4

phospho-p-S-NCAPG
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305110
data source: Provenance1
xref: UnificationXref8657
feature: FragmentFeature1423
feature: ModificationFeature244
cellular location: GO_0005829
comment: Reactome DB_ID: 5591272

phospho-p-S570-NCAPH
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184202
data source: Provenance1
xref: UnificationXref8656
feature: FragmentFeature1422
feature: ModificationFeature243
cellular location: GO_0005829
comment: Reactome DB_ID: 5591274

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219933
data source: Provenance1
name: SMC2L1
name: CAPE
name: SMC-2
name: Chromosome-associated protein E
name: SMC protein 2
name: PRO0324
name: XCAP-E homolog
name: Structural maintenance of chromosomes protein 2
name: DDB0219933
xref: UnificationXref8648
feature: FragmentFeature1417
cellular location: GO_0005829
comment: Reactome DB_ID: 5591256
display name: SMC2

hCAP-H
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184202
data source: Provenance1
name: Barren homolog protein 1
name: XCAP-H homolog
name: Chromosome-associated protein H
name: Non-SMC condensin I complex subunit H
name: DDB0184202
name: Note: the coordinates are copied over from Homo sapiens.
name: NCAPH
name: CAPH
name: BRRN1
name: KIAA0074
name: Condensin complex subunit 2
xref: UnificationXref8647
feature: FragmentFeature1416
cellular location: GO_0005829
comment: Reactome DB_ID: 5591251
display name: BRRN

hCAP-G
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305110
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: XCAP-G homolog
name: Chromosome-associated protein G
name: NCAPG
name: NYMEL3
name: Non-SMC condensin I complex subunit G
name: Condensin subunit CAP-G
name: Melanoma antigen NY-MEL-3
name: Condensin complex subunit 3
name: DDB0305110
xref: UnificationXref8652
feature: FragmentFeature1419
cellular location: GO_0005829
comment: Reactome DB_ID: 5591255
display name: CAPG

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304964
data source: Provenance1
name: Chromosome-associated protein D2
name: KIAA0159
name: XCAP-D2 homolog
name: CNAP1
name: Chromosome condensation-related SMC-associated protein 1
name: Non-SMC condensin I complex subunit D2
name: hCAP-D2
name: Condensin complex subunit 1
name: DDB0304964
name: NCAPD2
xref: UnificationXref8650
feature: FragmentFeature1418
cellular location: GO_0005829
comment: Reactome DB_ID: 5591247
display name: CAPD2

phospho-p-STAG2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238657
data source: Provenance1
xref: UnificationXref8637
feature: FragmentFeature1414
feature: ModificationFeature240
cellular location: GO_0005694
comment: Reactome DB_ID: 5591134

phospho-p-S454-RAD21
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305113
data source: Provenance1
xref: UnificationXref8638
feature: FragmentFeature1415
feature: ModificationFeature241
cellular location: GO_0005694
comment: Reactome DB_ID: 5591136

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201629
data source: Provenance1
name: DDB0201629
name: Multidrug resistance protein 1
name: MDR1_HUMAN
xref: UnificationXref8438
feature: FragmentFeature1369
cellular location: GO_0005886
comment: Reactome DB_ID: 5589286
display name: ABCB1

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

NDOR1_HUMAN
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266666
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: NADPH-dependent diflavin oxidoreductase 1 ecNumber1.6.-.-/ecNumber
name: DDB0266666
xref: UnificationXref8484
feature: FragmentFeature1372
cellular location: GO_0005829
comment: Reactome DB_ID: 5591367
display name: NDOR1

Homologues of NUBP2
type: Protein
data source: Provenance1
member physical entity: DDB0232414
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8500
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5591381

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201670
data source: Provenance1
name: Multidrug resistance protein 1
name: MDR1_HUMAN
name: DDB0201670
xref: UnificationXref8439
feature: FragmentFeature1370
cellular location: GO_0005886
comment: Reactome DB_ID: 5589287
display name: ABCB1

DDB0216275
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216275
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CPIN1_HUMAN
name: Anamorsin
xref: UnificationXref8478
feature: FragmentFeature1371
cellular location: GO_0005829
comment: Reactome DB_ID: 5591362
display name: CIAPIN1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232424
data source: Provenance1
name: Cytosolic Fe-S cluster assembly factor NUBP1
name: DDB0232424
name: NUBP1_HUMAN
xref: UnificationXref8502
feature: FragmentFeature1375
cellular location: GO_0005829
comment: Reactome DB_ID: 5591385
display name: NUBP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201625
data source: Provenance1
name: ATP-binding cassette sub-family B member 7, mitochondrial
name: DDB0201625
name: ABCB7(?-752)
name: ABCB7
name: ABCB7_HUMAN
xref: UnificationXref8506
feature: FragmentFeature1376
cellular location: GO_0005743
comment: Reactome DB_ID: 5586263
display name: ABC7

DDB0232414
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232414
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytosolic Fe-S cluster assembly factor NUBP2
name: NUBP2_HUMAN
xref: UnificationXref8497
feature: FragmentFeature1373
cellular location: GO_0005829
comment: Reactome DB_ID: 5591376
display name: NUBP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232423
data source: Provenance1
name: DDB0232423
name: Cytosolic Fe-S cluster assembly factor NUBP2
name: NUBP2_HUMAN
xref: UnificationXref8499
feature: FragmentFeature1374
cellular location: GO_0005829
comment: Reactome DB_ID: 5591380
display name: NUBP2

http://identifiers.org/pubmed/6022858
type: PublicationXref
id: 6022858
author: Younathan, ES
author: Pynes, GD
db: Pubmed
title: Purification and some properties of inorganic pyrophosphatase from human erythrocytes
source: J Biol Chem 242:2119-23
year: 1967

Apoprotein Lacking 4Fe-4S Cluster
type: Protein
data source: Provenance1
member physical entity: Fanconi anemia group J protein
member physical entity: apo-POLD1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8516
cellular location: GO_0005829
comment: Reactome DB_ID: 5591418
comment: Converted from EntitySet in Reactome

UniProt:DDB0231591
type: ProteinReference
xref: UnificationXref6023
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231592
type: ProteinReference
xref: UnificationXref6050
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231594
type: ProteinReference
xref: UnificationXref6036
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/2770297
type: PublicationXref
id: 2770297
author: Thomas, JL
author: Myers, RP
author: Strickler, RC
db: Pubmed
title: Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
source: J Steroid Biochem 33:209-17
year: 1989

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229398
data source: Provenance1
xref: UnificationXref8553
feature: FragmentFeature1391
feature: ModificationFeature231
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590938

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229419
data source: Provenance1
xref: UnificationXref8555
feature: ModificationFeature232
feature: FragmentFeature1392
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590940

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191203
data source: Provenance1
xref: UnificationXref8549
feature: FragmentFeature1389
feature: ModificationFeature229
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590934

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229420
data source: Provenance1
xref: UnificationXref8551
feature: FragmentFeature1390
feature: ModificationFeature230
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590936

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229413
data source: Provenance1
xref: UnificationXref8545
feature: FragmentFeature1387
feature: ModificationFeature227
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590930

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191476
data source: Provenance1
xref: UnificationXref8547
feature: FragmentFeature1388
feature: ModificationFeature228
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590932

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201658
data source: Provenance1
xref: UnificationXref8543
feature: FragmentFeature1386
feature: ModificationFeature226
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590928

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232004
data source: Provenance1
name: RBP1
name: Retinoblastoma-associated protein
name: Rb-binding protein 1
name: pRb
name: DDB0232004
name: Retinoblastoma Protein 1
xref: UnificationXref8570
feature: FragmentFeature1395
cellular location: GO_0005654
comment: Reactome DB_ID: 5578978
display name: RB1

DDB0216332
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216332
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8561
feature: FragmentFeature1393
cellular location: GO_0005829
comment: Reactome DB_ID: 5583473
display name: PLK1

phospho-p-S189,T216,S274,S373-GORASP1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238345
data source: Provenance1
xref: UnificationXref8563
feature: ModificationFeature223
feature: ModificationFeature224
feature: ModificationFeature233
feature: ModificationFeature222
feature: FragmentFeature1394
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590947

UniProt:DDB0231575
type: ProteinReference
xref: UnificationXref2711
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

UniProt:DDB0231574
type: ProteinReference
xref: UnificationXref3986
organism: http://identifiers.org/taxonomy/44689

Fanconi anemia group J protein
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232367
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: apo-BRIP1 (apo-FANCJ)
name: apo-FANCJ
name: DDB0232367
name: apo-BRIP1
name: FANCJ_HUMAN
xref: UnificationXref8515
feature: FragmentFeature1379
cellular location: GO_0005829
comment: Reactome DB_ID: 5591417
display name: BRIP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267133
data source: Provenance1
name: FAM96B
name: DDB0267133
name: Mitotic spindle-associated MMXD complex subunit MIP18
xref: UnificationXref8518
feature: FragmentFeature1380
cellular location: GO_0005829
comment: Reactome DB_ID: 5591403
display name: MIP18

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235234
data source: Provenance1
name: DDB0235234
name: MMS19 nucleotide excision repair protein homolog
xref: UnificationXref8520
feature: FragmentFeature1381
cellular location: GO_0005829
comment: Reactome DB_ID: 5591407
display name: MMS19

DDB0266484
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266484
data source: Provenance1
name: NARFL_HUMAN
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytosolic Fe-S cluster assembly factor NARFL
xref: UnificationXref8522
feature: FragmentFeature1382
cellular location: GO_0005829
comment: Reactome DB_ID: 5591394
display name: NARFL

apo-POLD1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232268
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA polymerase delta catalytic subunit ecNumber2.7.7.7/ecNumber
name: DPOD1_HUMAN
name: DDB0232268
xref: UnificationXref8511
feature: FragmentFeature1377
cellular location: GO_0005829
comment: Reactome DB_ID: 5591412
display name: POLD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191272
data source: Provenance1
name: apo-XPD
name: ERCC2_HUMAN
name: TFIIH basal transcription factor complex helicase XPD subunit ecNumber3.6.4.12/ecNumber
name: DDB0191272
name: apo-ERCC2
xref: UnificationXref8513
feature: FragmentFeature1378
cellular location: GO_0005829
comment: Reactome DB_ID: 5591413
display name: ERCC2

WDR39
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266672
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0266672
name: Probable cytosolic iron-sulfur protein assembly protein CIAO1
xref: UnificationXref8525
feature: FragmentFeature1383
cellular location: GO_0005829
comment: Reactome DB_ID: 5591399
display name: CIAO1

phospho-p-T216,S274,S373-GORASP1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238345
data source: Provenance1
xref: UnificationXref8539
feature: ModificationFeature223
feature: ModificationFeature224
feature: ModificationFeature222
feature: FragmentFeature1384
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590924

Homologues of p-T195-RAB1A
type: Protein
data source: Provenance1
member physical entity: phospho-p-T195-RAB1A
xref: UnificationXref8556
cellular location: Golgi membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5590941

phospho-p-T195-RAB1A
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229406
data source: Provenance1
xref: UnificationXref8541
feature: FragmentFeature1385
feature: ModificationFeature225
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590926

UniProt:DDB0231560
type: ProteinReference
xref: UnificationXref14142
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238066
data source: Provenance1
name: DDB0238066
name: PLA2G6
xref: UnificationXref5101
feature: FragmentFeature1007
cellular location: GO_0005829
comment: Reactome DB_ID: 5589392
display name: iPLA2

DDB0238064
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238064
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PLA2G6
xref: UnificationXref5103
feature: FragmentFeature1008
cellular location: GO_0005829
comment: Reactome DB_ID: 5589393
display name: iPLA2

Homologues of PLA2G6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0238064
xref: UnificationXref5104
cellular location: GO_0005829
comment: Reactome DB_ID: 5589394
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238065
data source: Provenance1
name: DDB0238065
name: PLA2G6
xref: UnificationXref5099
feature: FragmentFeature1006
cellular location: GO_0005829
comment: Reactome DB_ID: 5589391
display name: iPLA2

Lysophospholipid acyltransferase 1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304755
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LPLAT 1
name: DDB0304755
xref: UnificationXref5111
feature: FragmentFeature1010
cellular location: GO_0005789
comment: Reactome DB_ID: 5589353
display name: MBOAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304755
data source: Provenance1
name: Lysophospholipid acyltransferase 2
name: LPLAT 2
name: DDB0304755
xref: UnificationXref5112
feature: FragmentFeature1011
cellular location: GO_0005789
comment: Reactome DB_ID: 5589329
display name: MBOAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220116
data source: Provenance1
name: DDB0220116
name: Phospholipase B-like 1
xref: UnificationXref5106
feature: FragmentFeature1009
cellular location: GO_0005829
comment: Reactome DB_ID: 5589348
display name: PLBD1

LPEAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Lysophospholipid acyltransferase 1
xref: UnificationXref5114
cellular location: GO_0005789
comment: Reactome DB_ID: 5589357
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252759
data source: Provenance1
name: PISDA
name: PISD(1-377)
name: Phosphatidylserine decarboxylase proenzyme Chain A
name: DDB0252759
xref: UnificationXref5081
feature: FragmentFeature1004
cellular location: GO_0005743
comment: Reactome DB_ID: 5589568
display name: PISD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204189
data source: Provenance1
name: PISDA
name: DDB0204189
name: PISD(1-377)
name: Phosphatidylserine decarboxylase proenzyme Chain A
xref: UnificationXref5082
feature: FragmentFeature1005
cellular location: GO_0005743
comment: Reactome DB_ID: 5589572
display name: PISD

phosphatidylserine
type: SmallMolecule
entity reference: CHEBI_18303
data source: Provenance1
xref: UnificationXref10278
xref: UnificationXref10279
cellular location: GO_0009897
comment: Reactome DB_ID: 939747
display name: PS

phosphatidylethanolamine
type: SmallMolecule
entity reference: SmallMoleculeReference361
data source: Provenance1
xref: UnificationXref10276
xref: UnificationXref10277
cellular location: GO_0009897
comment: Reactome DB_ID: 947595
display name: PE

aminophospholipids
type: SmallMolecule
data source: Provenance1
member physical entity: phosphatidylserine
member physical entity: phosphatidylethanolamine
xref: UnificationXref10280
cellular location: GO_0009897
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588411
display name: APLs

Copper
type: SmallMolecule
entity reference: CHEBI_29036
data source: Provenance1
xref: UnificationXref10263
xref: UnificationXref10262
cellular location: GO_0005796
comment: Reactome DB_ID: 936901
display name: Cu2+

GDP-alpha-D-mannose
type: SmallMolecule
entity reference: CHEBI_15820
data source: Provenance1
name: guanosine 5'-(3-(alpha-D-mannopyranosyl) dihydrogen diphosphate)
xref: UnificationXref10191
xref: UnificationXref10192
cellular location: GO_0005796
comment: Reactome DB_ID: 744233
display name: GDP-Man

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI_17345
data source: Provenance1
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref10190
xref: UnificationXref10189
cellular location: GO_0005796
comment: Reactome DB_ID: 744239
display name: GMP

Copper
type: SmallMolecule
entity reference: CHEBI_29036
data source: Provenance1
xref: UnificationXref10261
xref: UnificationXref10260
cellular location: GO_0005829
comment: Reactome DB_ID: 209799
display name: Cu2+

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI_18248
data source: Provenance1
xref: UnificationXref10249
xref: UnificationXref10250
cellular location: GO_0031904
comment: Reactome DB_ID: 917810
display name: Fe2+

H+
type: SmallMolecule
entity reference: CHEBI_15378
data source: Provenance1
xref: UnificationXref10227
xref: UnificationXref10228
cellular location: GO_0031904
comment: Reactome DB_ID: 74722

heme
type: SmallMolecule
entity reference: CHEBI_17627
data source: Provenance1
xref: UnificationXref10223
xref: UnificationXref10224
cellular location: GO_0005576
comment: Reactome DB_ID: 917877

Homologues of EPT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5063
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589436

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266710
data source: Provenance1
name: DDB0266710
name: Ethanolaminephosphotransferase 1
xref: UnificationXref5061
feature: FragmentFeature998
cellular location: GO_0005789
comment: Reactome DB_ID: 5589434
display name: EPT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266713
data source: Provenance1
name: Ethanolaminephosphotransferase 1
name: DDB0266713
xref: UnificationXref5062
feature: FragmentFeature999
cellular location: GO_0005789
comment: Reactome DB_ID: 5589435
display name: EPT1

Homologues of PISD(378-409)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5079
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589577

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184541
data source: Provenance1
name: PISD(378-409)
name: DDB0184541
name: Phosphatidylserine decarboxylase proenzyme Chain B
xref: UnificationXref5074
feature: FragmentFeature1000
cellular location: GO_0005743
comment: Reactome DB_ID: 5589574
display name: PISDB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252759
data source: Provenance1
name: PISD(378-409)
name: Phosphatidylserine decarboxylase proenzyme Chain B
name: DDB0252759
xref: UnificationXref5076
feature: FragmentFeature1001
cellular location: GO_0005743
comment: Reactome DB_ID: 5589575
display name: PISDB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204189
data source: Provenance1
name: PISD(378-409)
name: DDB0204189
name: Phosphatidylserine decarboxylase proenzyme Chain B
xref: UnificationXref5078
feature: FragmentFeature1002
cellular location: GO_0005743
comment: Reactome DB_ID: 5589576
display name: PISDB

Homologues of PISD(1-377)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5083
cellular location: GO_0005743
comment: Reactome DB_ID: 5589573
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266712
data source: Provenance1
name: DDB0266712
name: Choline/ethanolaminephosphotransferase 1
xref: UnificationXref5058
feature: FragmentFeature997
cellular location: GO_0005789
comment: Reactome DB_ID: 5589428
display name: CEPT1

GABA
type: SmallMolecule
entity reference: CHEBI_16865
data source: Provenance1
xref: UnificationXref10377
xref: UnificationXref10378
cellular location: GO_0005759
comment: Reactome DB_ID: 916850

3-Methoxy-4-hydroxyphenylglycol
type: SmallMolecule
entity reference: CHEBI_16436
data source: Provenance1
xref: UnificationXref10368
xref: UnificationXref10369
cellular location: GO_0005829
comment: Reactome DB_ID: 374926

5-hydroxytryptamine N-methyl conjugate
type: SmallMolecule
entity reference: CHEBI 3210
data source: Provenance1
xref: UnificationXref10395
xref: UnificationXref10396
cellular location: GO_0005829
comment: Reactome DB_ID: 159363
display name: 5HT-N-CH3

aminophospholipids
type: SmallMolecule
data source: Provenance1
member physical entity: phosphatidylserine
member physical entity: phosphatidylethanolamine
xref: UnificationXref10286
cellular location: GO_0009898
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588412
display name: APLs

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184541
data source: Provenance1
name: DDB0184541
name: PISDA
name: PISD(1-377)
name: Phosphatidylserine decarboxylase proenzyme Chain A
xref: UnificationXref5080
feature: FragmentFeature1003
cellular location: GO_0005743
comment: Reactome DB_ID: 5589564
display name: PISD

phosphatidylserine
type: SmallMolecule
entity reference: CHEBI_18303
data source: Provenance1
xref: UnificationXref10284
xref: UnificationXref10285
cellular location: GO_0009898
comment: Reactome DB_ID: 947592
display name: PS

phosphatidylethanolamine
type: SmallMolecule
entity reference: SmallMoleculeReference361
data source: Provenance1
xref: UnificationXref10282
xref: UnificationXref10283
cellular location: GO_0009898
comment: Reactome DB_ID: 939760
display name: PE

nicotinic acid adenine dinucleotide phosphate
type: SmallMolecule
entity reference: CHEBI_31906
data source: Provenance1
xref: UnificationXref10325
xref: UnificationXref10324
cellular location: GO_0005829
comment: Reactome DB_ID: 2730676
display name: NAADP

Calcium
type: SmallMolecule
entity reference: CHEBI_29108
data source: Provenance1
xref: UnificationXref10314
xref: UnificationXref10315
cellular location: GO_0043202
comment: Reactome DB_ID: 1606834
display name: Ca2+

Norepinephrine
type: SmallMolecule
entity reference: CHEBI_18357
data source: Provenance1
name: Noradrenaline
xref: UnificationXref10366
xref: UnificationXref10365
cellular location: GO_0005829
comment: Reactome DB_ID: 209789
display name: NAd

Chloride
type: SmallMolecule
entity reference: CHEBI_17996
data source: Provenance1
xref: UnificationXref10338
xref: UnificationXref10337
cellular location: GO_0031904
comment: Reactome DB_ID: 2731008
display name: Cl-

Homologues of CEPT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5059
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589429

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266710
data source: Provenance1
name: DDB0266710
name: Choline/ethanolaminephosphotransferase 1
xref: UnificationXref5052
feature: FragmentFeature994
cellular location: GO_0005789
comment: Reactome DB_ID: 5589416
display name: CEPT1

DDB0191331
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191331
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphorylethanolamine transferase
name: Ethanolamine-phosphate cytidylyltransferase
xref: UnificationXref5029
feature: FragmentFeature992
cellular location: GO_0005789
comment: Reactome DB_ID: 5589544
display name: PCYT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168507
data source: Provenance1
name: DDB0168507
name: lipin 3
xref: UnificationXref5037
feature: FragmentFeature993
cellular location: GO_0005789
comment: Reactome DB_ID: 5589556
display name: LPIN3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267033
data source: Provenance1
name: ETNK2
name: Ethanolamine kinase 2
name: DDB0267033
xref: UnificationXref5017
feature: FragmentFeature990
cellular location: GO_0005829
comment: Reactome DB_ID: 5589590
display name: EKI2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267034
data source: Provenance1
name: DDB0267034
name: ETNK2
name: Ethanolamine kinase 2
xref: UnificationXref5018
feature: FragmentFeature991
cellular location: GO_0005829
comment: Reactome DB_ID: 5589591
display name: EKI2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267034
data source: Provenance1
name: DDB0267034
name: ETNK1
name: Ethanolamine kinase 1
xref: UnificationXref5015
feature: FragmentFeature989
cellular location: GO_0005829
comment: Reactome DB_ID: 5589588
display name: EKI1

Homologues of ETNK2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5019
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589592

NDP
type: SmallMolecule
entity reference: CHEBI_16862
data source: Provenance1
xref: UnificationXref11356
xref: UnificationXref11355
cellular location: GO_0005654
comment: Reactome DB_ID: 30181

Deoxynucleoside triphosphate
type: SmallMolecule
entity reference: CHEBI_16516
data source: Provenance1
xref: UnificationXref10728
xref: UnificationXref10729
cellular location: GO_0005654
comment: Reactome DB_ID: 30555

Sugar phosphate
type: SmallMolecule
entity reference: ChEBI:33447 phospho sugar
data source: Provenance1
xref: UnificationXref10711
xref: UnificationXref10710
cellular location: GO_0005654
comment: Reactome DB_ID: 30977
display name: SUGP

2,4(1H,3H)-Pyrimidinedione, dihydro-
type: SmallMolecule
entity reference: CHEBI_15901
data source: Provenance1
name: Dihydrouracile
name: 5,6-Dihydrouracil
name: 5,6-Dihydro-2,4-dihydroxypyrimidine
name: dihydrouracil
xref: UnificationXref10674
xref: UnificationXref10675
cellular location: GO_0005654
comment: Reactome DB_ID: 30140
display name: Hydrouracil

5-hydroxyuracil
type: SmallMolecule
entity reference: CHEBI_29115
data source: Provenance1
name: 5-hydroxyluracil
xref: UnificationXref10662
xref: UnificationXref10661
cellular location: GO_0005654
comment: Reactome DB_ID: 110216
display name: 5OHU

Uracil
type: SmallMolecule
entity reference: CHEBI_17568
data source: Provenance1
xref: UnificationXref10655
xref: UnificationXref10656
cellular location: GO_0005654
comment: Reactome DB_ID: 29554
display name: Ura

formamidopyrimidine
type: SmallMolecule
entity reference: CHEBI_35877
data source: Provenance1
xref: UnificationXref10615
xref: UnificationXref10614
cellular location: GO_0005654
comment: Reactome DB_ID: 110228
display name: FAPY

8-oxoguanine
type: SmallMolecule
entity reference: 8-oxoguanine [ChEBI:29116]
data source: Provenance1
xref: UnificationXref10604
xref: UnificationXref10603
cellular location: GO_0005654
comment: Reactome DB_ID: 110242
display name: OGUA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191335
data source: Provenance1
name: Choline/ethanolaminephosphotransferase 1
name: DDB0191335
xref: UnificationXref5056
feature: FragmentFeature996
cellular location: GO_0005789
comment: Reactome DB_ID: 5589424
display name: CEPT1

gamma-aminobutyrate
type: SmallMolecule
entity reference: CHEBI_16865
data source: Provenance1
xref: UnificationXref10513
xref: UnificationXref10514
cellular location: GO_0005576
comment: Reactome DB_ID: 352003
display name: GABA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266713
data source: Provenance1
name: DDB0266713
name: Choline/ethanolaminephosphotransferase 1
xref: UnificationXref5054
feature: FragmentFeature995
cellular location: GO_0005789
comment: Reactome DB_ID: 5589420
display name: CEPT1

Dopamine
type: SmallMolecule
entity reference: CHEBI_18243
data source: Provenance1
xref: UnificationXref10403
xref: UnificationXref10402
cellular location: GO_0005829
comment: Reactome DB_ID: 159362
display name: DA

Homologues of PLD2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4985
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589510

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231506
data source: Provenance1
name: Phospholipase D2
name: DDB0231506
xref: UnificationXref4982
feature: FragmentFeature984
cellular location: GO_0005789
comment: Reactome DB_ID: 5589507
display name: PLD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231508
data source: Provenance1
name: Phospholipase D2
name: DDB0231508
xref: UnificationXref4983
feature: FragmentFeature985
cellular location: GO_0005789
comment: Reactome DB_ID: 5589508
display name: PLD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231507
data source: Provenance1
name: Phospholipase D2
name: DDB0231507
xref: UnificationXref4984
feature: FragmentFeature986
cellular location: GO_0005789
comment: Reactome DB_ID: 5589509
display name: PLD2

magnesium
type: SmallMolecule
entity reference: CHEBI_18420
data source: Provenance1
name: Mg++
xref: UnificationXref11414
xref: UnificationXref11413
cellular location: GO_0005759
comment: Reactome DB_ID: 109496
display name: Mg2+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231506
data source: Provenance1
name: Phospholipase D1
name: DDB0231506
xref: UnificationXref4976
feature: FragmentFeature981
cellular location: GO_0005789
comment: Reactome DB_ID: 5589497
display name: PLD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231507
data source: Provenance1
name: Phospholipase D1
name: DDB0231507
xref: UnificationXref4978
feature: FragmentFeature982
cellular location: GO_0005789
comment: Reactome DB_ID: 5589501
display name: PLD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231508
data source: Provenance1
name: Phospholipase D1
name: DDB0231508
xref: UnificationXref4980
feature: FragmentFeature983
cellular location: GO_0005789
comment: Reactome DB_ID: 5589505
display name: PLD1

glutathione disulfide
type: SmallMolecule
entity reference: CHEBI_17858
data source: Provenance1
name: oxidized glutathione
xref: UnificationXref11510
xref: UnificationXref11511
cellular location: GO_0005759
comment: Reactome DB_ID: 1655882
display name: GSSG

SO2.-
type: SmallMolecule
entity reference: CHEBI_18421
data source: Provenance1
name: Superoxide
xref: UnificationXref11486
xref: UnificationXref11485
cellular location: GO_0005758
comment: Reactome DB_ID: 3341308
display name: O2-

Copper
type: SmallMolecule
entity reference: CHEBI_29036
data source: Provenance1
xref: UnificationXref11469
xref: UnificationXref11468
cellular location: GO_0005576
comment: Reactome DB_ID: 437295
display name: Cu2+

SO2.-
type: SmallMolecule
entity reference: CHEBI_18421
data source: Provenance1
name: Superoxide
xref: UnificationXref11497
xref: UnificationXref11498
cellular location: GO_0005576
comment: Reactome DB_ID: 3299686
display name: O2.-

SO2.-
type: SmallMolecule
entity reference: CHEBI_18421
data source: Provenance1
name: Superoxide
xref: UnificationXref11490
xref: UnificationXref11489
cellular location: GO_0005759
comment: Reactome DB_ID: 3299683
display name: O2.-

Homologues of ETNK1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5016
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589589

Cu(I)
type: SmallMolecule
entity reference: CHEBI_49552
data source: Provenance1
name: copper(1+)
xref: UnificationXref11439
xref: UnificationXref11438
cellular location: GO_0005758
comment: Reactome DB_ID: 3780989
display name: Cu1+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0169489
data source: Provenance1
name: DDB0169489
name: MAGL
name: Monoglyceride lipase
xref: UnificationXref5000
feature: FragmentFeature987
cellular location: GO_0005789
comment: Reactome DB_ID: 5589333
display name: MGLL

Cu(I)
type: SmallMolecule
entity reference: CHEBI_49552
data source: Provenance1
name: copper(1+)
xref: UnificationXref11424
xref: UnificationXref11423
cellular location: GO_0005829
comment: Reactome DB_ID: 3299744
display name: Cu1+

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1141
pathway component: BiochemicalReaction1140
evidence: Evidence1752
xref: UnificationXref11167
xref: UnificationXref11166
xref: RelationshipXref1483
pathway order: PathwayStep1718
pathway order: PathwayStep1717
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Copper
type: SmallMolecule
entity reference: CHEBI_29036
data source: Provenance1
xref: UnificationXref11454
xref: UnificationXref11455
cellular location: GO_0005758
comment: Reactome DB_ID: 3777113
display name: Cu2+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267033
data source: Provenance1
name: ETNK1
name: Ethanolamine kinase 1
name: DDB0267033
xref: UnificationXref5013
feature: FragmentFeature988
cellular location: GO_0005829
comment: Reactome DB_ID: 5589584
display name: EKI1

Zn(II)
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
name: Zn++
name: Zinc ion
xref: UnificationXref11443
xref: UnificationXref11444
cellular location: GO_0005758
comment: Reactome DB_ID: 3777117
display name: Zn2+

http://identifiers.org/pubmed/12949583
type: PublicationXref
id: 12949583
author: van den Bosch, M
author: Lowndes, NF
author: Bree, RT
db: Pubmed
title: The MRN complex: coordinating and mediating the response to broken chromosomes.
source: EMBO Rep 4:844-9
year: 2003

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1272
evidence: Evidence1931
xref: UnificationXref12516
xref: UnificationXref12517
pathway order: PathwayStep1894
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304755
data source: Provenance1
name: MBOA5_HUMAN
name: MBOAT5
name: Lysophospholipid acyltransferase 5
name: DDB0304755
xref: UnificationXref5113
feature: FragmentFeature1012
cellular location: GO_0005789
comment: Reactome DB_ID: 5589328
display name: LPCAT3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0217387
data source: Provenance1
name: DDB0217387
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref5128
feature: FragmentFeature1013
cellular location: GO_0005829
comment: Reactome DB_ID: 5589474
display name: GDE5

Homologues of GPCPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5133
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589483

Homologues of CHPT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5164
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589443
comment: Converted from EntitySet in Reactome

GABA receptor activation
type: Pathway
data source: Provenance1
pathway component: REACT 222527.2
evidence: Evidence1612
xref: UnificationXref10562
xref: UnificationXref10561
pathway order: PathwayStep1581
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231750
data source: Provenance1
name: Choline-phosphate cytidylyltransferase B
name: DDB0231750
name: Phosphorylcholine transferase B
name: PCYT1B
xref: UnificationXref5151
feature: FragmentFeature1018
cellular location: GO_0005789
comment: Reactome DB_ID: 5589460
display name: CCTB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266710
data source: Provenance1
name: DDB0266710
name: Cholinephosphotransferase 1
name: Diacylglycerol cholinephosphotransferase 1
name: CHPT1
xref: UnificationXref5162
feature: FragmentFeature1019
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589441
display name: CPT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188719
data source: Provenance1
name: DDB0188719
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref5132
feature: FragmentFeature1015
cellular location: GO_0005829
comment: Reactome DB_ID: 5589482
display name: GDE5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168012
data source: Provenance1
name: DDB0168012
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref5130
feature: FragmentFeature1014
cellular location: GO_0005829
comment: Reactome DB_ID: 5589478
display name: GDE5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231750
data source: Provenance1
name: CCT-alpha
name: DDB0231750
name: Choline-phosphate cytidylyltransferase A
xref: UnificationXref5149
feature: FragmentFeature1017
cellular location: GO_0005789
comment: Reactome DB_ID: 5589458
display name: PCYT1A

DDB0267052
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267052
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PNMT
name: PEMT2
name: PEMPT
name: Phosphatidylethanolamine N-methyltransferase
name: PEAMT
xref: UnificationXref5139
feature: FragmentFeature1016
cellular location: GO_0005789
comment: Reactome DB_ID: 5589532
display name: PEMT

PPi
type: SmallMoleculeReference
name: PPi [ChEBI:29888]
xref: UnificationXref1544

http://identifiers.org/pubmed/15585754
type: PublicationXref
id: 15585754
author: Hicklin, DJ
author: Ellis, LM
db: Pubmed
title: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
source: J Clin Oncol 23:1011-27
year: 2005

UnificationXref2965
type: UnificationXref
id: 5584824
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584824

UnificationXref2964
type: UnificationXref
id: DDB0235216
db: UniProt

http://identifiers.org/pubmed/11208594
type: PublicationXref
id: 11208594
author: Rabelink, TJ
author: Govers, R
db: Pubmed
title: Cellular regulation of endothelial nitric oxide synthase
source: Am J Physiol Renal Physiol 280:F193-206
year: 2001

UnificationXref2967
type: UnificationXref
id: 5584825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584825

UnificationXref2966
type: UnificationXref
id: DDB0235262
db: UniProt

UnificationXref2969
type: UnificationXref
id: 5584826
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584826

UnificationXref2968
type: UnificationXref
id: DDB0230077
db: UniProt

UnificationXref2960
type: UnificationXref
id: DDB0235220
db: UniProt

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

UnificationXref2961
type: UnificationXref
id: 5584822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584822

UnificationXref2962
type: UnificationXref
id: DDB0230068
db: UniProt

UnificationXref2963
type: UnificationXref
id: 5584823
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584823

UniProt:DDB0231613
type: ProteinReference
xref: UnificationXref13490
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231612
type: ProteinReference
xref: UnificationXref13484
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231615
type: ProteinReference
xref: UnificationXref13488
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231614
type: ProteinReference
xref: UnificationXref13486
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

SequenceSite4204
type: SequenceSite
position status: EQUAL
sequence position: 534

UniProt:DDB0231608
type: ProteinReference
xref: UnificationXref7489
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/18772128
type: PublicationXref
id: 18772128
author: Riekhof, WR
author: Voelker, DR
author: Gijon, MA
author: Zarini, S
author: Murphy, RC
db: Pubmed
title: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
source: J Biol Chem 283:30235-45
year: 2008

SequenceSite4203
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4202
type: SequenceSite
position status: EQUAL
sequence position: 316

SequenceSite4201
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4200
type: SequenceSite
position status: EQUAL
sequence position: 708

UniProt:DDB0231609
type: ProteinReference
xref: UnificationXref7497
organism: http://identifiers.org/taxonomy/44689

UnificationXref2956
type: UnificationXref
id: DDB0235222
db: UniProt

UnificationXref2955
type: UnificationXref
id: 5584819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584819

UnificationXref2954
type: UnificationXref
id: DDB0230071
db: UniProt

UnificationXref2953
type: UnificationXref
id: REACT_218325
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_218325.2

UnificationXref2959
type: UnificationXref
id: 5584821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584821

UnificationXref2958
type: UnificationXref
id: DDB0234164
db: UniProt

UnificationXref2957
type: UnificationXref
id: 5584820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584820

http://identifiers.org/pubmed/9914469
type: PublicationXref
id: 9914469
author: Lang, J
db: Pubmed
title: Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
source: Eur J Biochem 259:3-17
year: 1999

UnificationXref2951
type: UnificationXref
id: REACT_254415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254415.1

UnificationXref2952
type: UnificationXref
id: 5592753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592753

UnificationXref2950
type: UnificationXref
id: 5584879
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584879

UniProt:DDB0231604
type: ProteinReference
xref: UnificationXref7470
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231603
type: ProteinReference
xref: UnificationXref7468
organism: http://identifiers.org/taxonomy/44689

SequenceSite4211
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4210
type: SequenceSite
position status: EQUAL
sequence position: 1390

SequenceSite4213
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4212
type: SequenceSite
position status: EQUAL
sequence position: 365

SequenceSite4215
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4214
type: SequenceSite
position status: EQUAL
sequence position: 677

UnificationXref2987
type: UnificationXref
id: 5584835
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584835

UnificationXref2986
type: UnificationXref
id: DDB0230079
db: UniProt

UnificationXref2989
type: UnificationXref
id: 5584836
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584836

UnificationXref2988
type: UnificationXref
id: DDB0235300
db: UniProt

UnificationXref2982
type: UnificationXref
id: DDB0304694
db: UniProt

UnificationXref2983
type: UnificationXref
id: 5584833
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584833

UnificationXref2984
type: UnificationXref
id: DDB0235304
db: UniProt

UnificationXref2985
type: UnificationXref
id: 5584834
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584834

UnificationXref2980
type: UnificationXref
id: DDB0235264
db: UniProt

UnificationXref2981
type: UnificationXref
id: 5584832
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584832

SequenceSite4205
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4206
type: SequenceSite
position status: EQUAL
sequence position: 204

SequenceSite4207
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4208
type: SequenceSite
position status: EQUAL
sequence position: 204

Pyrimidine salvage reactions
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction666
pathway component: BiochemicalReaction665
pathway component: BiochemicalReaction664
pathway component: BiochemicalReaction663
evidence: Evidence995
xref: UnificationXref6812
xref: UnificationXref6813
xref: RelationshipXref945
pathway order: PathwayStep971
pathway order: PathwayStep972
pathway order: PathwayStep973
pathway order: PathwayStep974
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4209
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4222
type: SequenceSite
position status: EQUAL
sequence position: 408

SequenceSite4221
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4220
type: SequenceSite
position status: EQUAL
sequence position: 519

SequenceSite4226
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite4225
type: SequenceSite
position status: EQUAL
sequence position: 33

SequenceSite4224
type: SequenceSite
position status: EQUAL
sequence position: 289

SequenceSite4223
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/23604073
type: PublicationXref
id: 23604073
author: Ablasser, A
author: Hopfner, KP
author: Deimling, Tobias
author: Hornung, V
author: Cavlar, Taner
db: Pubmed
title: Species-specific detection of the antiviral small-molecule compound CMA by STING
source: EMBO J. 32:1440-50
year: 2013

UnificationXref2979
type: UnificationXref
id: 5584831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584831

UnificationXref2978
type: UnificationXref
id: DDB0237714
db: UniProt

UnificationXref2977
type: UnificationXref
id: 5584830
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584830

UnificationXref2976
type: UnificationXref
id: DDB0230074
db: UniProt

UnificationXref2975
type: UnificationXref
id: 5584829
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584829

UnificationXref2973
type: UnificationXref
id: 5584828
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584828

UnificationXref2974
type: UnificationXref
id: DDB0235176
db: UniProt

UnificationXref2971
type: UnificationXref
id: 5584827
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584827

UnificationXref2972
type: UnificationXref
id: DDB0235218
db: UniProt

UnificationXref2970
type: UnificationXref
id: DDB0237650
db: UniProt

SequenceSite4218
type: SequenceSite
position status: EQUAL
sequence position: 886

SequenceSite4219
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4216
type: SequenceSite
position status: EQUAL
sequence position: 2624

SequenceSite4217
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231621
type: ProteinReference
xref: UnificationXref4277
organism: http://identifiers.org/taxonomy/44689

SequenceSite4234
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4235
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4236
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4237
type: SequenceSite
position status: EQUAL
sequence position: 274

SequenceSite4230
type: SequenceSite
position status: EQUAL
sequence position: 141

SequenceSite4231
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4232
type: SequenceSite
position status: EQUAL
sequence position: 274

SequenceSite4233
type: SequenceSite
position status: EQUAL
sequence position: 57

SequenceSite4228
type: SequenceSite
position status: EQUAL
sequence position: 1

Activation of PKB
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1397
pathway component: BiochemicalReaction1396
evidence: Evidence2169
xref: UnificationXref13851
xref: UnificationXref13852
pathway order: PathwayStep2129
pathway order: PathwayStep2130
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4227
type: SequenceSite
position status: EQUAL
sequence position: 141

SequenceSite4229
type: SequenceSite
position status: EQUAL
sequence position: 274

UnificationXref2999
type: UnificationXref
id: 5584841
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584841

SequenceSite4240
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2997
type: UnificationXref
id: 5584840
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584840

UnificationXref2998
type: UnificationXref
id: DDB0230078
db: UniProt

SequenceSite4247
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4248
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4245
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4246
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4243
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4244
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4241
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite4242
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4239
type: SequenceSite
position status: EQUAL
sequence position: 274

SequenceSite4238
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2992
type: UnificationXref
id: DDB0235205
db: UniProt

UnificationXref2991
type: UnificationXref
id: 5584837
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584837

UnificationXref2990
type: UnificationXref
id: DDB0231390
db: UniProt

UnificationXref2996
type: UnificationXref
id: DDB0235263
db: UniProt

UnificationXref2995
type: UnificationXref
id: 5584839
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584839

UnificationXref2994
type: UnificationXref
id: DDB0235175
db: UniProt

UnificationXref2993
type: UnificationXref
id: 5584838
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584838

SequenceSite4250
type: SequenceSite
position status: EQUAL
sequence position: 19

AKT phosphorylates targets in the nucleus
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction102
evidence: Evidence195
xref: UnificationXref1684
xref: UnificationXref1683
pathway order: PathwayStep178
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4251
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite4252
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4253
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite4254
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4255
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite4256
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4257
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4258
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4259
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4249
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4261
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4262
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite4260
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite4265
type: SequenceSite
position status: EQUAL
sequence position: 261

SequenceSite4266
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4263
type: SequenceSite
position status: EQUAL
sequence position: 222

SequenceSite4264
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4269
type: SequenceSite
position status: EQUAL
sequence position: 261

Carnitine synthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction764
evidence: Evidence1109
xref: UnificationXref7602
xref: UnificationXref7601
xref: RelationshipXref1092
pathway order: PathwayStep1088
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4267
type: SequenceSite
position status: EQUAL
sequence position: 261

http://identifiers.org/pubmed/22118461
type: PublicationXref
id: 22118461
author: Desai, Arshad
author: Hombauer, Hans
author: Smith, Catherine E
author: Campbell, Christopher S
author: Kolodner, Richard D
db: Pubmed
title: Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
source: Cell 147:1040-53
year: 2011

SequenceSite4268
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231684
type: ProteinReference
xref: UnificationXref8213
organism: http://identifiers.org/taxonomy/44689

CaM pathway
type: Pathway
data source: Provenance1
pathway component: REACT 203280.2
pathway component: BiochemicalReaction87
evidence: Evidence180
xref: UnificationXref1624
xref: UnificationXref1623
pathway order: PathwayStep163
pathway order: PathwayStep153
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4165
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4164
type: SequenceSite
position status: EQUAL
sequence position: 251

SequenceSite4167
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4166
type: SequenceSite
position status: EQUAL
sequence position: 677

SequenceSite4169
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4168
type: SequenceSite
position status: EQUAL
sequence position: 339

SequenceSite4161
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4160
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite4163
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4162
type: SequenceSite
position status: EQUAL
sequence position: 1199

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

http://identifiers.org/pubmed/11130078
type: PublicationXref
id: 11130078
author: Sato, S
author: Takeda, K
author: Wagner, H
author: Sanjo, H
author: Takeuchi, O
author: Hoshino, K
author: Matsumoto, M
author: Kaisho, T
author: Kawai, T
author: Hemmi, H
author: Akira, S
db: Pubmed
title: A Toll-like receptor recognizes bacterial DNA
source: Nature 408:740-5
year: 2000

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

UniProt:DDB0231698
type: ProteinReference
xref: UnificationXref13034
organism: http://identifiers.org/taxonomy/44689

SequenceSite4156
type: SequenceSite
position status: EQUAL
sequence position: 124

SequenceSite4155
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4154
type: SequenceSite
position status: EQUAL
sequence position: 1826

SequenceSite4153
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4159
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4158
type: SequenceSite
position status: EQUAL
sequence position: 264

SequenceSite4157
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4152
type: SequenceSite
position status: EQUAL
sequence position: 1872

SequenceSite4151
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4150
type: SequenceSite
position status: EQUAL
sequence position: 439

SequenceSite4187
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4186
type: SequenceSite
position status: EQUAL
sequence position: 126

SequenceSite4189
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4188
type: SequenceSite
position status: EQUAL
sequence position: 1135

SequenceSite4183
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4182
type: SequenceSite
position status: EQUAL
sequence position: 476

SequenceSite4185
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

SequenceSite4184
type: SequenceSite
position status: EQUAL
sequence position: 133

SequenceSite4181
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4180
type: SequenceSite
position status: EQUAL
sequence position: 1970

UnificationXref2909
type: UnificationXref
id: 5584627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584627

UnificationXref2908
type: UnificationXref
id: 5584625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584625

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

UnificationXref2907
type: UnificationXref
id: DDB0231513
db: UniProt

UnificationXref2906
type: UnificationXref
id: REACT_11705
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11705.2

SequenceSite4179
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4178
type: SequenceSite
position status: EQUAL
sequence position: 109

SequenceSite4177
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4176
type: SequenceSite
position status: EQUAL
sequence position: 376

UniProt:DDB0219336
type: ProteinReference
xref: UnificationXref8846
organism: http://identifiers.org/taxonomy/44689

SequenceSite4175
type: SequenceSite
position status: EQUAL
sequence position: 275

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

UnificationXref2901
type: UnificationXref
id: CHEBI:7916
db: ChEBI

SequenceSite4174
type: SequenceSite
position status: EQUAL
sequence position: 274

UnificationXref2900
type: UnificationXref
id: REACT_222598
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222598.2

SequenceSite4173
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4172
type: SequenceSite
position status: EQUAL
sequence position: 161

SequenceSite4171
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2905
type: UnificationXref
id: 196786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196786

SequenceSite4170
type: SequenceSite
position status: EQUAL
sequence position: 800

UnificationXref2904
type: UnificationXref
id: CHEBI:15905
db: ChEBI

UnificationXref2903
type: UnificationXref
id: REACT_11841
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11841.2

UnificationXref2902
type: UnificationXref
id: 196820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196820

UniProt:DDB0231647
type: ProteinReference
xref: UnificationXref11522
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

carboxylic acid [ChEBI:33575]
type: SmallMoleculeReference
name: acidos carboxilicos
name: acide carboxylique
name: acido carboxilico
name: Carbonsaeure
name: RC(=O)OH
name: acides carboxyliques
name: Carbonsaeuren
name: carboxylic acid
name: Karbonsaeure
xref: UnificationXref6000

UnificationXref2913
type: UnificationXref
id: 5584868
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584868

UnificationXref2914
type: UnificationXref
id: REACT_258787
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258787.1

UnificationXref2915
type: UnificationXref
id: CHEBI:17561
db: ChEBI

UnificationXref2916
type: UnificationXref
id: 111707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111707

UnificationXref2910
type: UnificationXref
id: REACT_263812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263812.1

UnificationXref2911
type: UnificationXref
id: 5584865
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584865

UnificationXref2912
type: UnificationXref
id: 5584866
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584866

UnificationXref2917
type: UnificationXref
id: REACT_7424
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7424.4

UnificationXref2918
type: UnificationXref
id: CHEBI:15769
db: ChEBI

UnificationXref2919
type: UnificationXref
id: 196834
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196834

UniProt:DDB0231659
type: ProteinReference
xref: UnificationXref13163
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231657
type: ProteinReference
xref: UnificationXref3109
organism: http://identifiers.org/taxonomy/44689

UnificationXref2926
type: UnificationXref
id: CHEBI:16858
db: ChEBI

SequenceSite4191
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2927
type: UnificationXref
id: 196767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196767

SequenceSite4192
type: SequenceSite
position status: EQUAL
sequence position: 346

UnificationXref2924
type: UnificationXref
id: 5584599
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584599

UnificationXref2925
type: UnificationXref
id: REACT_248555
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248555.1

SequenceSite4190
type: SequenceSite
position status: EQUAL
sequence position: 1720

UnificationXref2922
type: UnificationXref
id: 5584596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584596

SequenceSite4195
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2923
type: UnificationXref
id: 5584597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584597

SequenceSite4196
type: SequenceSite
position status: EQUAL
sequence position: 1133

UnificationXref2920
type: UnificationXref
id: REACT_11378
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11378.2

SequenceSite4193
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2921
type: UnificationXref
id: DDB0231514
db: UniProt

SequenceSite4194
type: SequenceSite
position status: EQUAL
sequence position: 651

SequenceSite4199
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4197
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4198
type: SequenceSite
position status: EQUAL
sequence position: 108

http://identifiers.org/pubmed/9305837
type: PublicationXref
id: 9305837
author: Mäder, A W
author: Luger, K
author: Richmond, R K
author: Sargent, D F
author: Richmond, T J
db: Pubmed
title: Crystal structure of the nucleosome core particle at 2.8 A resolution
source: Nature 389:251-60
year: 1997

UnificationXref2928
type: UnificationXref
id: REACT_11300
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11300.2

UnificationXref2929
type: UnificationXref
id: DDB0231515
db: UniProt

UniProt:DDB0231664
type: ProteinReference
xref: UnificationXref1834
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231665
type: ProteinReference
xref: UnificationXref13183
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231666
type: ProteinReference
xref: UnificationXref13181
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231660
type: ProteinReference
xref: UnificationXref13172
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231661
type: ProteinReference
xref: UnificationXref13170
organism: http://identifiers.org/taxonomy/44689

UnificationXref2930
type: UnificationXref
id: 5584618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584618

UnificationXref2931
type: UnificationXref
id: 5584619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584619

Cell death signalling via NRAGE, NRIF and NADE
type: Pathway
data source: Provenance1
pathway component: REACT 211603.2
evidence: Evidence2182
xref: RelationshipXref1729
xref: UnificationXref13961
xref: UnificationXref13960
pathway order: PathwayStep2143
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref2932
type: UnificationXref
id: 5584621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584621

UnificationXref2933
type: UnificationXref
id: REACT_259777
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259777.1

UnificationXref2934
type: UnificationXref
id: CHEBI:15468
db: ChEBI

UnificationXref2935
type: UnificationXref
id: 196778
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196778

UnificationXref2936
type: UnificationXref
id: REACT_11629
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11629.2

UnificationXref2937
type: UnificationXref
id: DDB0231517
db: UniProt

UnificationXref2938
type: UnificationXref
id: 5584603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584603

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

UnificationXref2939
type: UnificationXref
id: 5584605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584605

http://identifiers.org/pubmed/19767751
type: PublicationXref
id: 19767751
author: Kosako, H
author: Hattori, S
author: Taniguchi, H
author: Kose, S
author: Ushiyama, M
author: Nishida, E
author: Imamoto, N
author: Aranami, C
author: Yamaguchi, N
db: Pubmed
title: Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
source: Nat Struct Mol Biol 16:1026-35
year: 2009

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

UnificationXref2941
type: UnificationXref
id: 5584614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584614

UnificationXref2940
type: UnificationXref
id: REACT_259838
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259838.1

UnificationXref2944
type: UnificationXref
id: REACT_3654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3654.2

UnificationXref2945
type: UnificationXref
id: DDB0234096
db: UniProt

UnificationXref2942
type: UnificationXref
id: REACT_258912
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258912.1

UnificationXref2943
type: UnificationXref
id: 29374
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29374

UnificationXref2948
type: UnificationXref
id: 5584876
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584876

UnificationXref2949
type: UnificationXref
id: 5584877
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584877

UnificationXref2946
type: UnificationXref
id: 5584872
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5584872

UnificationXref2947
type: UnificationXref
id: DDB0234093
db: UniProt

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

http://identifiers.org/pubmed/15838516
type: PublicationXref
id: 15838516
author: Cobrinik, D
db: Pubmed
title: Pocket proteins and cell cycle control
source: Oncogene 24:2796-809
year: 2005

http://identifiers.org/pubmed/9593664
type: PublicationXref
id: 9593664
author: Maehama, T
author: Dixon, JE
db: Pubmed
title: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
source: J Biol Chem 273:13375-8
year: 1998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188248
data source: Provenance1
name: Fatty acyl-CoA reductase 1
name: DDB0188248
xref: UnificationXref4557
feature: FragmentFeature946
cellular location: GO_0005782
comment: Reactome DB_ID: 5586585
display name: FAR1

DDB0167887
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0167887
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 3-ketoacyl-CoA thiolase, peroxisomal
name: Acetyl-Coenzyme A acyltransferase 1
xref: UnificationXref4542
feature: FragmentFeature945
cellular location: GO_0005782
comment: Reactome DB_ID: 5586567
display name: ACAA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231402
data source: Provenance1
name: Isocitrate dehydrogenase (NADP) cytoplasmic
name: DDB0231402
name: PICD
xref: UnificationXref4569
feature: FragmentFeature947
cellular location: GO_0005782
comment: Reactome DB_ID: 5586337
display name: IDH1

Homologues of IDH1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4571
cellular location: GO_0005782
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586339

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234153
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 3
name: DDB0234153
xref: UnificationXref4480
feature: FragmentFeature942
cellular location: GO_0005782
comment: Reactome DB_ID: 5586416
display name: ACOX3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234168
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 3
name: DDB0234168
xref: UnificationXref4478
feature: FragmentFeature941
cellular location: GO_0005782
comment: Reactome DB_ID: 5586412
display name: ACOX3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214891
data source: Provenance1
name: DDB0214891
name: ABCD1
xref: UnificationXref4514
feature: FragmentFeature944
cellular location: GO_0005778
comment: Reactome DB_ID: 5586271
display name: ALDP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201628
data source: Provenance1
name: Peroxisomal multifunctional enzyme type 2
name: hydroxysteroid (17-beta) dehydrogenase 4
name: HSD17B4(2-736)
name: DDB0201628
name: DHB4_HUMAN
xref: UnificationXref4491
feature: FragmentFeature943
cellular location: GO_0005782
comment: Reactome DB_ID: 5583967
display name: HSD17B4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231393
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 3
name: DDB0231393
xref: UnificationXref4474
feature: FragmentFeature939
cellular location: GO_0005782
comment: Reactome DB_ID: 5586404
display name: ACOX3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234144
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 3
name: DDB0234144
xref: UnificationXref4476
feature: FragmentFeature940
cellular location: GO_0005782
comment: Reactome DB_ID: 5586408
display name: ACOX3

http://identifiers.org/pubmed/9153396
type: PublicationXref
id: 9153396
author: Vousden, KH
author: Kubbutat, MH
author: Jones, SN
db: Pubmed
title: Regulation of p53 stability by Mdm2.
source: Nature 387:299-303
year: 1997

http://identifiers.org/pubmed/9153395
type: PublicationXref
id: 9153395
author: Haupt, Y
author: Maya, R
author: Oren, M
author: Kazaz, A
db: Pubmed
title: Mdm2 promotes the rapid degradation of p53.
source: Nature 387:296-9
year: 1997

2-Amino-3-methylbutyric acid
type: SmallMolecule
entity reference: CHEBI_16414
data source: Provenance1
name: L-Valine
xref: UnificationXref9979
xref: UnificationXref9978
cellular location: GO_0005576
comment: Reactome DB_ID: 351992
display name: L-Val

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI_16828
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref9977
xref: UnificationXref9976
cellular location: GO_0005576
comment: Reactome DB_ID: 352006
display name: L-Trp

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref9975
xref: UnificationXref9974
cellular location: GO_0005576
comment: Reactome DB_ID: 352000
display name: L-Thr

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI_17203
data source: Provenance1
name: L-Proline
xref: UnificationXref9971
xref: UnificationXref9972
cellular location: GO_0005576
comment: Reactome DB_ID: 352033
display name: L-Pro

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule300
member physical entity: 2,6-diaminohexanoic acid
member physical entity: L-Threonine
member physical entity: SmallMolecule301
member physical entity: SmallMolecule858
member physical entity: SmallMolecule859
member physical entity: SmallMolecule160
member physical entity: SmallMolecule99
member physical entity: SmallMolecule849
member physical entity: SmallMolecule287
member physical entity: SmallMolecule908
member physical entity: SmallMolecule888
member physical entity: SmallMolecule860
member physical entity: 2-Pyrrolidinecarboxylic acid
member physical entity: SmallMolecule43
member physical entity: SmallMolecule110
member physical entity: SmallMolecule100
member physical entity: SmallMolecule203
member physical entity: SmallMolecule115
member physical entity: SmallMolecule240
xref: UnificationXref9994
cellular location: GO_0005829
comment: Reactome DB_ID: 5586944
comment: Converted from EntitySet in Reactome

Glycine
type: SmallMolecule
entity reference: CHEBI_15428
data source: Provenance1
name: Aminoacetic acid
xref: UnificationXref9984
xref: UnificationXref9985
cellular location: GO_0005576
comment: Reactome DB_ID: 266029
display name: Gly

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Provenance1
xref: UnificationXref9982
xref: UnificationXref9983
cellular location: GO_0005576
comment: Reactome DB_ID: 352002
display name: L-Ser

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI_17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref9981
xref: UnificationXref9980
cellular location: GO_0005576
comment: Reactome DB_ID: 352016
display name: Cys

L-Methionine
type: SmallMolecule
entity reference: CHEBI_16643
data source: Provenance1
xref: UnificationXref9969
xref: UnificationXref9970
cellular location: GO_0005576
comment: Reactome DB_ID: 351966
display name: L-Met

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

L-Isoleucine
type: SmallMolecule
entity reference: L-Isoleucine [ChEBI:17191]
data source: Provenance1
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref9966
xref: UnificationXref9965
cellular location: GO_0005576
comment: Reactome DB_ID: 352001
display name: L-Ile

L-Leucine
type: SmallMolecule
entity reference: CHEBI_15603
data source: Provenance1
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref9968
xref: UnificationXref9967
cellular location: GO_0005576
comment: Reactome DB_ID: 351964
display name: L-Leu

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: CHEBI_18019
data source: Provenance1
name: Lysine acid
name: L-Lysine
xref: UnificationXref9938
xref: UnificationXref9937
cellular location: GO_0005829
comment: Reactome DB_ID: 351979
display name: L-Lys

cationic amino acids
type: SmallMolecule
data source: Provenance1
member physical entity: 2,6-diaminohexanoic acid
member physical entity: SmallMolecule43
xref: UnificationXref9939
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5585783
display name: L-Arg, L-Lys, L-Orn

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref9956
xref: UnificationXref9955
cellular location: GO_0005576
comment: Reactome DB_ID: 351980
display name: L-Asn

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: 2-Amino-3-methylbutyric acid
member physical entity: SmallMolecule952
member physical entity: SmallMolecule1099
member physical entity: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
member physical entity: L-Threonine
member physical entity: L-Asparagine
member physical entity: 2-Pyrrolidinecarboxylic acid
member physical entity: L-Glutaminic acid
member physical entity: Glycine
member physical entity: 2-aminosuccinic acid
member physical entity: L-serine
member physical entity: (S)-alpha-Amino-1H-imidazole-4-propionic acid
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: L-Glutamine
member physical entity: L-Methionine
member physical entity: SmallMolecule277
member physical entity: L-Isoleucine
member physical entity: SmallMolecule947
member physical entity: L-Leucine
member physical entity: SmallMolecule102
xref: UnificationXref9986
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586940

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref9959
xref: UnificationXref9960
cellular location: GO_0005576
comment: Reactome DB_ID: 210382
display name: L-Glu

2-aminosuccinic acid
type: SmallMolecule
entity reference: 2-aminosuccinic acid
data source: Provenance1
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref9957
xref: UnificationXref9958
cellular location: GO_0005576
comment: Reactome DB_ID: 351973
display name: L-Asp

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI_15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref9964
xref: UnificationXref9963
cellular location: GO_0005576
comment: Reactome DB_ID: 351970
display name: L-His

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref9962
xref: UnificationXref9961
cellular location: GO_0005576
comment: Reactome DB_ID: 212615
display name: L-Gln

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: CHEBI_18019
data source: Provenance1
name: Lysine acid
name: L-Lysine
xref: UnificationXref10030
xref: UnificationXref10031
cellular location: GO_0043202
comment: Reactome DB_ID: 428004
display name: L-Lys

L-Methionine
type: SmallMolecule
entity reference: CHEBI_16643
data source: Provenance1
xref: UnificationXref10032
xref: UnificationXref10033
cellular location: GO_0043202
comment: Reactome DB_ID: 428001
display name: L-Met

DDB0305146
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305146
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 3-beta-HSD II
xref: UnificationXref4891
feature: FragmentFeature974
cellular location: GO_0005789
comment: Reactome DB_ID: 5583980
display name: HSD3B2

L-Leucine
type: SmallMolecule
entity reference: CHEBI_15603
data source: Provenance1
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref10028
xref: UnificationXref10029
cellular location: GO_0043202
comment: Reactome DB_ID: 427983
display name: L-Leu

DDB0302376
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302376
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cholesterol 25-hydroxylase
name: CH25H_HUMAN
xref: UnificationXref4873
feature: FragmentFeature972
cellular location: GO_0005829
comment: Reactome DB_ID: 5583952
display name: CH25H

3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305146
data source: Provenance1
name: DDB0305146
name: Note: the coordinates are copied over from Homo sapiens.
name: 3BH1_HUMAN
name: 3-beta-HSD I
xref: UnificationXref4889
feature: FragmentFeature973
cellular location: GO_0005789
comment: Reactome DB_ID: 5583978
display name: HSD3B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201629
data source: Provenance1
name: DDB0201629
name: ATP-binding cassette sub-family B member 11
name: Bile salt export pump
xref: UnificationXref4843
feature: FragmentFeature970
cellular location: GO_0005886
comment: Reactome DB_ID: 5583997
display name: ABCB11

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201670
data source: Provenance1
name: DDB0201670
name: ATP-binding cassette sub-family B member 11
name: Bile salt export pump
xref: UnificationXref4844
feature: FragmentFeature971
cellular location: GO_0005886
comment: Reactome DB_ID: 5584001
display name: ABCB11

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI_17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref10047
xref: UnificationXref10046
cellular location: GO_0043202
comment: Reactome DB_ID: 427991
display name: L-Cys

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: CHEBI_17895
data source: Provenance1
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref10043
xref: UnificationXref10042
cellular location: GO_0043202
comment: Reactome DB_ID: 427993
display name: L-Tyr

2-Amino-3-methylbutyric acid
type: SmallMolecule
entity reference: CHEBI_16414
data source: Provenance1
name: L-Valine
xref: UnificationXref10045
xref: UnificationXref10044
cellular location: GO_0043202
comment: Reactome DB_ID: 428002
display name: L-Val

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref10038
xref: UnificationXref10039
cellular location: GO_0043202
comment: Reactome DB_ID: 427964
display name: L-Thr

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI_16828
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref10041
xref: UnificationXref10040
cellular location: GO_0043202
comment: Reactome DB_ID: 427978
display name: L-Trp

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI_17295
data source: Provenance1
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref10034
xref: UnificationXref10035
cellular location: GO_0043202
comment: Reactome DB_ID: 427949
display name: L-Phe

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI_17203
data source: Provenance1
name: L-Proline
xref: UnificationXref10036
xref: UnificationXref10037
cellular location: GO_0043202
comment: Reactome DB_ID: 427962
display name: L-Pro

Homologues of ABCB11
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4845
cellular location: GO_0005886
comment: Reactome DB_ID: 5584002
comment: Converted from EntitySet in Reactome

DDB0305146
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305146
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
name: 3 beta-hydroxysteroid dehydrogenase type 7
xref: UnificationXref4781
feature: FragmentFeature969
cellular location: GO_0005789
comment: Reactome DB_ID: 5583959
display name: HSD3B7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191312
data source: Provenance1
name: DDB0191312
name: 7-dehydrocholesterol reductase
xref: UnificationXref4756
feature: FragmentFeature968
cellular location: GO_0005789
comment: Reactome DB_ID: 5584590
display name: DHCR7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267002
data source: Provenance1
name: Delta(8)-Delta(7) sterol isomerase
name: Emopamil-binding protein
name: DDB0267002
xref: UnificationXref4746
feature: FragmentFeature967
cellular location: GO_0005789
comment: Reactome DB_ID: 5584463
display name: EBP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233059
data source: Provenance1
name: sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
name: DDB0233059
xref: UnificationXref4723
feature: FragmentFeature966
cellular location: GO_0005789
comment: Reactome DB_ID: 5584041
display name: NSDHL

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref9992
xref: UnificationXref9993
cellular location: GO_0005829
comment: Reactome DB_ID: 351990
display name: L-Thr

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI_15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref10013
xref: UnificationXref10012
cellular location: GO_0043202
comment: Reactome DB_ID: 428038
display name: L-His

DDB0266928
type: Protein
entity reference: UniProt:DDB0266928
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Estradiol 17-beta-dehydrogenase 1
xref: UnificationXref4955
feature: FragmentFeature978
cellular location: GO_0005829
comment: Reactome DB_ID: 5588108
display name: HSD17B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232044
data source: Provenance1
name: DDB0232044
name: Estradiol 17-beta-dehydrogenase 1
xref: UnificationXref4956
feature: FragmentFeature979
cellular location: GO_0005829
comment: Reactome DB_ID: 5588109
display name: HSD17B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187976
data source: Provenance1
name: LPAAT-epsilon
name: 1-AGP acyltransferase 5
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
name: DDB0187976
name: 1-acylglycerol-3-phosphate O-acyltransferase 5
name: Lysophosphatidic acid acyltransferase-epsilon
xref: UnificationXref4969
feature: FragmentFeature980
cellular location: GO_0005741
comment: Reactome DB_ID: 5589339
display name: AGPAT5

Homologues of PLD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4981
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589506

2-aminosuccinic acid
type: SmallMolecule
entity reference: 2-aminosuccinic acid
data source: Provenance1
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref10020
xref: UnificationXref10021
cellular location: GO_0043202
comment: Reactome DB_ID: 427963
display name: L-Asp

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref10022
xref: UnificationXref10023
cellular location: GO_0043202
comment: Reactome DB_ID: 428017
display name: L-Glu

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref10024
xref: UnificationXref10025
cellular location: GO_0043202
comment: Reactome DB_ID: 428006
display name: L-Gln

L-Isoleucine
type: SmallMolecule
entity reference: L-Isoleucine [ChEBI:17191]
data source: Provenance1
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref10026
xref: UnificationXref10027
cellular location: GO_0043202
comment: Reactome DB_ID: 427955
display name: L-Ile

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: 2,6-diaminohexanoic acid
member physical entity: L-Methionine
member physical entity: (S)-alpha-Amino-1H-imidazole-4-propionic acid
member physical entity: L-Leucine
member physical entity: L-serine
member physical entity: Glycine
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: 2-aminosuccinic acid
member physical entity: L-Glutaminic acid
member physical entity: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
member physical entity: L-Glutamine
member physical entity: 2-Amino-3-methylbutyric acid
member physical entity: L-Isoleucine
member physical entity: L-Threonine
member physical entity: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
member physical entity: L-alpha-Alanine
member physical entity: (S)-2-Amino-5-guanidinovaleric acid
member physical entity: L-Phenylalanine
member physical entity: L-Asparagine
member physical entity: 2-Pyrrolidinecarboxylic acid
xref: UnificationXref10052
cellular location: GO_0043202
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586968

L-alpha-Alanine
type: SmallMolecule
entity reference: CHEBI_16977
data source: Provenance1
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref10014
xref: UnificationXref10015
cellular location: GO_0043202
comment: Reactome DB_ID: 428020
display name: L-Ala

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI_16467
data source: Provenance1
name: L-Arginine
xref: UnificationXref10017
xref: UnificationXref10016
cellular location: GO_0043202
comment: Reactome DB_ID: 428011
display name: L-Arg

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref10018
xref: UnificationXref10019
cellular location: GO_0043202
comment: Reactome DB_ID: 428042
display name: L-Asn

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI_17203
data source: Provenance1
name: L-Proline
xref: UnificationXref9990
xref: UnificationXref9991
cellular location: GO_0005829
comment: Reactome DB_ID: 113538
display name: L-Pro

HSD17B3-like Proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4944
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583989

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302650
data source: Provenance1
name: Corticosteroid 11-beta-dehydrogenase, isozyme 1
name: DDB0302650
xref: UnificationXref4910
feature: FragmentFeature976
cellular location: GO_0005789
comment: Reactome DB_ID: 5584023
display name: HSD11B1

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

Homologues of HSD17B1
type: Protein
data source: Provenance1
member physical entity: DDB0266928
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4957
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588110

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238277
data source: Provenance1
name: DDB0238277
name: Estradiol 17beta-dehydrogenase
xref: UnificationXref4943
feature: FragmentFeature977
cellular location: GO_0005789
comment: Reactome DB_ID: 5583988
display name: HSD17B3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302651
data source: Provenance1
name: Corticosteroid 11-beta-dehydrogenase, isozyme 1
name: DDB0302651
xref: UnificationXref4908
feature: FragmentFeature975
cellular location: GO_0005789
comment: Reactome DB_ID: 5584019
display name: HSD11B1

Homologues of HSD11B1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4911
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5584024

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302479
data source: Provenance1
name: DDB0302479
name: Mevalonate kinase
xref: UnificationXref4609
feature: FragmentFeature952
cellular location: GO_0005829
comment: Reactome DB_ID: 5583916
display name: MVK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252847
data source: Provenance1
name: Diphosphomevalonate decarboxylase
name: DDB0252847
xref: UnificationXref4620
feature: FragmentFeature953
cellular location: GO_0005829
comment: Reactome DB_ID: 5583938
display name: MVD

Zn(II)
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
name: Zn++
name: Zinc ion
xref: UnificationXref10106
xref: UnificationXref10107
cellular location: GO_0031904
comment: Reactome DB_ID: 435350
display name: Zn2+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231401
data source: Provenance1
name: Isocitrate dehydrogenase (NADP) cytoplasmic
name: DDB0231401
name: PICD
xref: UnificationXref4578
feature: FragmentFeature950
cellular location: GO_0005829
comment: Reactome DB_ID: 5586332
display name: IDH1

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

malonyl-CoA decarboxylase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188724
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MLYCD(40-493)
name: DDB0188724
xref: UnificationXref4588
feature: FragmentFeature951
cellular location: GO_0005782
comment: Reactome DB_ID: 5588594
display name: MLYCD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190001
data source: Provenance1
name: DDB0190001
name: farnesyl diphosphate synthase
xref: UnificationXref4636
feature: FragmentFeature955
cellular location: GO_0005829
comment: Reactome DB_ID: 5583867
display name: FDPS

Zinc 2+
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
xref: UnificationXref10129
xref: UnificationXref10128
cellular location: GO_0005796
comment: Reactome DB_ID: 216667
display name: Zn2+

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI_15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref10161
xref: UnificationXref10160
cellular location: GO_0005796
comment: Reactome DB_ID: 727753
display name: Ac-CoA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191342
data source: Provenance1
name: IDI1_HUMAN
name: DDB0191342
name: Isopentenyl-diphosphate delta-isomerase 1
xref: UnificationXref4628
feature: FragmentFeature954
cellular location: GO_0005829
comment: Reactome DB_ID: 5583923
display name: IDI1

zinc
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
name: Zn(II)
name: Zn++
xref: UnificationXref10113
xref: UnificationXref10114
cellular location: GO_0008021
comment: Reactome DB_ID: 437093
display name: Zn2+

Homologues of FDPS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4641
cellular location: GO_0005829
comment: Reactome DB_ID: 5583876
comment: Converted from EntitySet in Reactome

Zinc 2+
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
xref: UnificationXref10122
xref: UnificationXref10121
cellular location: GO_0034774
comment: Reactome DB_ID: 216785
display name: Zn2+

GDP-L-fucose
type: SmallMolecule
entity reference: GDP-L-fucose
data source: Provenance1
xref: UnificationXref10178
xref: UnificationXref10179
cellular location: GO_0005829
comment: Reactome DB_ID: 742368
display name: GDP-Fuc

GDP-L-fucose
type: SmallMolecule
entity reference: GDP-L-fucose
data source: Provenance1
xref: UnificationXref10180
xref: UnificationXref10181
cellular location: GO_0005796
comment: Reactome DB_ID: 205683
display name: GDP-Fuc

UDP-xylose
type: SmallMolecule
entity reference: CHEBI_16082
data source: Provenance1
xref: UnificationXref10167
xref: UnificationXref10168
cellular location: GO_0005829
comment: Reactome DB_ID: 742353
display name: UDP-Xyl

UDP-xylose
type: SmallMolecule
entity reference: CHEBI_16082
data source: Provenance1
xref: UnificationXref10169
xref: UnificationXref10170
cellular location: GO_0005796
comment: Reactome DB_ID: 742361
display name: UDP-xyl

http://identifiers.org/pubmed/59727
type: PublicationXref
id: 59727
author: Nachman, RL
author: Harpel, PC
db: Pubmed
title: Platelet alpha2-macroglobulin and alpha1-antitrypsin
source: J Biol Chem 251:4512-21
year: 1976

GDP-alpha-D-mannose
type: SmallMolecule
entity reference: CHEBI_15820
data source: Provenance1
name: guanosine 5'-(3-(alpha-D-mannopyranosyl) dihydrogen diphosphate)
xref: UnificationXref10187
xref: UnificationXref10188
cellular location: GO_0005829
comment: Reactome DB_ID: 162860
display name: GDP-Man

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231402
data source: Provenance1
name: Isocitrate dehydrogenase (NADP) cytoplasmic
name: DDB0231402
name: PICD
xref: UnificationXref4577
feature: FragmentFeature949
cellular location: GO_0005829
comment: Reactome DB_ID: 5586328
display name: IDH1

Homologues of IDH1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4579
cellular location: GO_0005829
comment: Reactome DB_ID: 5586333
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231401
data source: Provenance1
name: Isocitrate dehydrogenase (NADP) cytoplasmic
name: DDB0231401
name: PICD
xref: UnificationXref4570
feature: FragmentFeature948
cellular location: GO_0005782
comment: Reactome DB_ID: 5586338
display name: IDH1

http://identifiers.org/pubmed/16143825
type: PublicationXref
id: 16143825
author: Briere, JJ
author: El Ghouzzi, V
author: Djouadi, F
author: Favier, J
author: Gimenez, AP
author: Benit, P
author: Rustin, P
db: Pubmed
title: Succinate dehydrogenase deficiency in human
source: Cell Mol Life Sci 62:2317â2324
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234143
data source: Provenance1
name: DDB0234143
name: squalene epoxidase
name: Squalene monooxygenase
xref: UnificationXref4673
feature: FragmentFeature960
cellular location: GO_0005789
comment: Reactome DB_ID: 5583860
display name: SQLE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191311
data source: Provenance1
name: Lanosterol synthase
name: DDB0191311
xref: UnificationXref4681
feature: FragmentFeature961
cellular location: GO_0005789
comment: Reactome DB_ID: 5583910
display name: LSS

lanosterol 14alpha-demethylase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232962
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0232962
xref: UnificationXref4688
feature: FragmentFeature962
cellular location: GO_0005789
comment: Reactome DB_ID: 5584054
display name: CYP51A1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232079
data source: Provenance1
name: DDB0232079
xref: UnificationXref4704
feature: FragmentFeature963
cellular location: GO_0005635
comment: Reactome DB_ID: 5584048
display name: LBR

Cytosolic iron-sulfur cluster assembly
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction853
pathway component: BiochemicalReaction851
pathway component: BiochemicalReaction852
evidence: Evidence1247
xref: UnificationXref8533
xref: UnificationXref8534
pathway order: PathwayStep1226
pathway order: PathwayStep1225
pathway order: PathwayStep1224
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232079
data source: Provenance1
name: Sterol C14-reductase
name: DDB0232079
xref: UnificationXref4709
feature: FragmentFeature964
cellular location: GO_0005789
comment: Reactome DB_ID: 5584057
display name: TM7SF2

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Provenance1
xref: UnificationXref10049
xref: UnificationXref10048
cellular location: GO_0043202
comment: Reactome DB_ID: 427967
display name: L-Ser

DDB0302376
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302376
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: C-4 methylsterol oxidase
name: SC4MOL
xref: UnificationXref4716
feature: FragmentFeature965
cellular location: GO_0005789
comment: Reactome DB_ID: 5584035
display name: MSMO1

Glycine
type: SmallMolecule
entity reference: CHEBI_15428
data source: Provenance1
name: Aminoacetic acid
xref: UnificationXref10050
xref: UnificationXref10051
cellular location: GO_0043202
comment: Reactome DB_ID: 427960
display name: Gly

H+
type: SmallMolecule
entity reference: CHEBI_15378
data source: Provenance1
xref: UnificationXref10056
xref: UnificationXref10055
cellular location: GO_0043202
comment: Reactome DB_ID: 428040

hexoses transported by GLUT7/11
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule170
member physical entity: SmallMolecule174
xref: UnificationXref10076
cellular location: GO_0005576
comment: Reactome DB_ID: 5587061
comment: Converted from EntitySet in Reactome

hexoses transported by GLUT7/11
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule176
member physical entity: SmallMolecule179
xref: UnificationXref10077
cellular location: GO_0005829
comment: Reactome DB_ID: 5587062
comment: Converted from EntitySet in Reactome

compounds transported by GLUT9
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule170
member physical entity: SmallMolecule174
member physical entity: Uric acid
xref: UnificationXref10085
cellular location: GO_0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587081

Uric acid
type: SmallMolecule
entity reference: CHEBI_17775
data source: Provenance1
xref: UnificationXref10083
xref: UnificationXref10084
cellular location: GO_0005576
comment: Reactome DB_ID: 429056
display name: Urate

compounds transported by GLUT9
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule176
member physical entity: SmallMolecule179
member physical entity: SmallMolecule762
xref: UnificationXref10086
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587082

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI_18248
data source: Provenance1
name: Fe(II)
name: Fe++
xref: UnificationXref10095
xref: UnificationXref10094
cellular location: GO_0005576
comment: Reactome DB_ID: 435347
display name: Fe2+

Zn(II)
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
name: Zn++
name: Zinc ion
xref: UnificationXref10099
xref: UnificationXref10100
cellular location: GO_0005576
comment: Reactome DB_ID: 158417
display name: Zn2+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215017
data source: Provenance1
name: DDB0215017
name: farnesyl diphosphate synthase
xref: UnificationXref4640
feature: FragmentFeature957
cellular location: GO_0005829
comment: Reactome DB_ID: 5583875
display name: FDPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0206219
data source: Provenance1
name: DDB0206219
name: farnesyl diphosphate synthase
xref: UnificationXref4638
feature: FragmentFeature956
cellular location: GO_0005829
comment: Reactome DB_ID: 5583871
display name: FDPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231376
data source: Provenance1
name: presqualene-di-diphosphate synthase
name: farnesyltransferase
name: Farnesyl-diphosphate farnesyltransferase
name: squalene synthase
name: DDB0231376
xref: UnificationXref4660
feature: FragmentFeature959
cellular location: GO_0005789
comment: Reactome DB_ID: 5583930
display name: FDFT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233098
data source: Provenance1
name: prenyltransferase
name: DDB0233098
name: Dimethylallyl trans-transferase
name: geranyl-diphosphate synthase
name: dimethylallyltransferase
name: GGPP synthase
name: geranylgeranyl pyrophosphate synthase 1
xref: UnificationXref4645
feature: FragmentFeature958
cellular location: GO_0005829
comment: Reactome DB_ID: 5583882
display name: GGPS1

DDB0230067
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230067
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Acetyl-CoA carboxylase 2
name: ACC-beta
name: ACACB
name: Biotin carboxylase
xref: UnificationXref4155
feature: FragmentFeature893
cellular location: GO_0005829
comment: Reactome DB_ID: 5583067
display name: ACC2

phospho-p-S79-ACACB
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230067
data source: Provenance1
xref: UnificationXref4156
feature: FragmentFeature894
feature: ModificationFeature183
cellular location: GO_0005829
comment: Reactome DB_ID: 5585006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233097
data source: Provenance1
name: DDB0233097
name: Diacylglycerol O-acyltransferase 2
xref: UnificationXref4134
feature: FragmentFeature891
cellular location: GO_0005789
comment: Reactome DB_ID: 5588017
display name: DGAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237605
data source: Provenance1
name: SLC25A20
name: DDB0237605
name: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
xref: UnificationXref4150
feature: FragmentFeature892
cellular location: GO_0005743
comment: Reactome DB_ID: 5585013
display name: CACT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168507
data source: Provenance1
name: DDB0168507
name: lipin 2
xref: UnificationXref4118
feature: FragmentFeature889
cellular location: GO_0005789
comment: Reactome DB_ID: 5581701
display name: LPIN2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304727
data source: Provenance1
name: Diglyceride acyltransferase
name: DDB0304727
name: ACAT related gene product 1
name: Diacylglycerol O-acyltransferase 1
xref: UnificationXref4129
feature: FragmentFeature890
cellular location: GO_0005789
comment: Reactome DB_ID: 5581708
display name: DGAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0168507
data source: Provenance1
name: DDB0168507
name: lipin 1
xref: UnificationXref4117
feature: FragmentFeature888
cellular location: GO_0005789
comment: Reactome DB_ID: 5581700
display name: LPIN1

phospho-p-T172-PRKAA2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215396
data source: Provenance1
xref: UnificationXref4162
feature: FragmentFeature897
feature: ModificationFeature184
cellular location: GO_0005829
comment: Reactome DB_ID: 5585000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237813
data source: Provenance1
name: AMPK gamma2 (inactive)
name: DDB0237813
xref: UnificationXref4160
feature: FragmentFeature896
cellular location: GO_0005829
comment: Reactome DB_ID: 5584996
display name: PRKAG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237814
data source: Provenance1
name: AMPK beta 2 (inactive)
name: DDB0237814
xref: UnificationXref4158
feature: FragmentFeature895
cellular location: GO_0005829
comment: Reactome DB_ID: 5584993
display name: PRKAB2

http://identifiers.org/pubmed/13295248
type: PublicationXref
id: 13295248
author: Stern, JR
author: Del Campillo, A
db: Pubmed
title: Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
source: J Biol Chem 218:985-1002
year: 1956

LPAAT-alpha
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0183825
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: G15 protein
name: Lysophosphatidic acid acyltransferase-alpha
name: 1-acylglycerol-3-phosphate O- acyltransferase 1
name: 1- AGP acyltransferase 1
name: DDB0183825
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
xref: UnificationXref4103
feature: FragmentFeature881
cellular location: GO_0005789
comment: Reactome DB_ID: 5581672
display name: AGPAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0183825
data source: Provenance1
name: Lysophosphatidic acid acyltransferase-beta
name: LPAAT-beta
name: 1-acylglycerol-3-phosphate O- acyltransferase 2
name: 1- AGP acyltransferase 2
name: DDB0183825
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
xref: UnificationXref4104
feature: FragmentFeature882
cellular location: GO_0005789
comment: Reactome DB_ID: 5581673
display name: AGPAT2

1- AGP acyltransferase 3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187976
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Lysophosphatidic acid acyltransferase-gamma
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
name: LPAAT-gamma
name: 1-acylglycerol-3-phosphate O- acyltransferase 3
name: DDB0187976
xref: UnificationXref4106
feature: FragmentFeature883
cellular location: GO_0005789
comment: Reactome DB_ID: 5581677
display name: AGPAT3

1-acyl-sn-glycerol-3-phosphate acyltransferase delta
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187976
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 1- AGP acyltransferase 4
name: 1-acylglycerol-3-phosphate O- acyltransferase 4
name: LPAAT-delta
name: Lysophosphatidic acid acyltransferase-delta
name: DDB0187976
xref: UnificationXref4107
feature: FragmentFeature884
cellular location: GO_0005789
comment: Reactome DB_ID: 5581678
display name: AGPAT4

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235400
data source: Provenance1
name: AGPAT6
name: glycerol-3-phosphate acyltransferase 4
name: DDB0235400
name: 1-acylglycerol-3-phosphate O-acyltransferase 6
xref: UnificationXref4097
feature: FragmentFeature880
cellular location: GO_0005789
comment: Reactome DB_ID: 5581683
display name: GPAT4

LPAAT
type: Protein
data source: Provenance1
member physical entity: AGPAT8
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: LPAAT-alpha
member physical entity: 1- AGP acyltransferase 3
member physical entity: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
xref: UnificationXref4111
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581686
display name: AGPAT

AGPAT8
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187976
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ALCAT1
name: 1-acylglycerol-3-phosphate O-acyltransferase 8
name: Lysocardiolipin acyltransferase 1
name: DDB0187976
xref: UnificationXref4109
feature: FragmentFeature886
cellular location: GO_0005789
comment: Reactome DB_ID: 5581684
display name: LCLAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0187976
data source: Provenance1
name: LPAAT-epsilon
name: 1-AGP acyltransferase 5
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
name: DDB0187976
name: 1-acylglycerol-3-phosphate O-acyltransferase 5
name: Lysophosphatidic acid acyltransferase-epsilon
xref: UnificationXref4108
feature: FragmentFeature885
cellular location: GO_0005789
comment: Reactome DB_ID: 5581679
display name: AGPAT5

LPIN1 or 2 or 3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4119
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581702
display name: lipins

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235400
data source: Provenance1
name: glycerol-3-phosphate acyltransferase 3
name: DDB0235400
name: AGPAT9
name: 1-acylglycerol-3-phosphate O-acyltransferase 9
xref: UnificationXref4110
feature: FragmentFeature887
cellular location: GO_0005789
comment: Reactome DB_ID: 5581685
display name: GPAT3

DDB0266928
type: Protein
entity reference: UniProt:DDB0266928
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 3-hydroxybutyrate dehydrogenase
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase)
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
xref: UnificationXref4304
feature: FragmentFeature906
cellular location: GO_0005759
comment: Reactome DB_ID: 5580934
display name: BDH1

Homologues of NFYC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4346
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589763

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0304567
data source: Provenance1
name: Nuclear transcription factor Y subunit gamma
name: NFYC_HUMAN
name: DDB0304567
name: NF-YC
xref: UnificationXref4341
feature: FragmentFeature909
cellular location: GO_0005654
comment: Reactome DB_ID: 5589754
display name: NFYC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235256
data source: Provenance1
name: DDB0235256
name: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor
name: Succinyl CoA:3-oxoacid CoA-transferase
name: 3-oxoacid CoA-transferase monomer
xref: UnificationXref4317
feature: FragmentFeature907
cellular location: GO_0005759
comment: Reactome DB_ID: 5581119
display name: OXCT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185769
data source: Provenance1
name: DDB0185769
xref: UnificationXref4337
feature: FragmentFeature908
cellular location: GO_0005743
comment: Reactome DB_ID: 5583752
display name: GPD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220099
data source: Provenance1
name: DDB0220099
name: NF-YB
xref: UnificationXref4348
feature: FragmentFeature912
cellular location: GO_0005654
comment: Reactome DB_ID: 5589750
display name: NFYB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220100
data source: Provenance1
name: DDB0220100
name: NF-YA
xref: UnificationXref4350
feature: FragmentFeature913
cellular location: GO_0005654
comment: Reactome DB_ID: 5589767
display name: NFYA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220097
data source: Provenance1
name: DDB0220097
name: Nuclear transcription factor Y subunit gamma
name: NFYC_HUMAN
name: NF-YC
xref: UnificationXref4343
feature: FragmentFeature910
cellular location: GO_0005654
comment: Reactome DB_ID: 5589758
display name: NFYC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302533
data source: Provenance1
name: DDB0302533
name: Nuclear transcription factor Y subunit gamma
name: NFYC_HUMAN
name: NF-YC
xref: UnificationXref4345
feature: FragmentFeature911
cellular location: GO_0005654
comment: Reactome DB_ID: 5589762
display name: NFYC

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI_29154
data source: Provenance1
xref: UnificationXref12349
xref: UnificationXref12350
cellular location: GO_0005759
comment: Reactome DB_ID: 379745

tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI_29177
data source: Provenance1
xref: UnificationXref12347
xref: UnificationXref12348
cellular location: GO_0005759
comment: Reactome DB_ID: 379775

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI_29153
data source: Provenance1
xref: UnificationXref12341
xref: UnificationXref12342
cellular location: GO_0005759
comment: Reactome DB_ID: 379789

Homologues of HMGCR-1
type: Protein
data source: Provenance1
member physical entity: DDB0191125
member physical entity: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-1
xref: UnificationXref4357
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583903

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref12367
xref: UnificationXref12366
cellular location: GO_0005759
comment: Reactome DB_ID: 379706
display name: L-Thr

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI_29162
data source: Provenance1
xref: UnificationXref12359
xref: UnificationXref12360
cellular location: GO_0005759
comment: Reactome DB_ID: 379777

tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI_29179
data source: Provenance1
xref: UnificationXref12357
xref: UnificationXref12358
cellular location: GO_0005759
comment: Reactome DB_ID: 379761

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Provenance1
xref: UnificationXref12356
xref: UnificationXref12355
cellular location: GO_0005759
comment: Reactome DB_ID: 379732
display name: L-Ser

tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI_29181
data source: Provenance1
xref: UnificationXref12376
xref: UnificationXref12375
cellular location: GO_0005759
comment: Reactome DB_ID: 379774

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI_29163
data source: Provenance1
xref: UnificationXref12371
xref: UnificationXref12370
cellular location: GO_0005759
comment: Reactome DB_ID: 379779

tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI_29180
data source: Provenance1
xref: UnificationXref12369
xref: UnificationXref12368
cellular location: GO_0005759
comment: Reactome DB_ID: 379791

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232942
data source: Provenance1
name: Enoyl-CoA hydratase 1
name: Short chain enoyl-CoA hydratase
name: DDB0232942
name: Enoyl-CoA hydratase, mitochondrial precursor
xref: UnificationXref4177
feature: FragmentFeature898
cellular location: GO_0005759
comment: Reactome DB_ID: 5581882
display name: ECHS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0205217
data source: Provenance1
name: short chain 3-hydroxyacyl-CoA dehydrogenase monomer
name: HCDH
name: Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase
name: DDB0205217
name: HCDH_HUMAN
name: Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor
xref: UnificationXref4191
feature: FragmentFeature899
cellular location: GO_0005759
comment: Reactome DB_ID: 5581875
display name: HADH

http://identifiers.org/pubmed/15526160
type: PublicationXref
id: 15526160
author: Rönnstrand, L
db: Pubmed
title: Signal transduction via the stem cell factor receptor/c-Kit
source: Cell Mol Life Sci 61:2535-48
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0231097
data source: Provenance1
name: methylmalonyl-CoA epimerase
name: methylmalonyl-CoA racemase
name: DDB0231097
xref: UnificationXref4268
feature: FragmentFeature900
cellular location: GO_0005759
comment: Reactome DB_ID: 5579546
display name: MCEE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231621
data source: Provenance1
name: Acetyl-CoA acetyltransferase, mitochondrial
name: acetyl-CoA acetyltransferase
name: Acetoacetyl-CoA thiolase
name: ACAT1(35-427)
name: DDB0231621
xref: UnificationXref4278
feature: FragmentFeature901
cellular location: GO_0005759
comment: Reactome DB_ID: 5579379
display name: ACAT1

Homologues of HMGCS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4289
cellular location: GO_0005759
comment: Reactome DB_ID: 5580948
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0217522
data source: Provenance1
name: DDB0217522
name: hydroxymethylglutaryl-CoA synthase
name: Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
name: HMG-CoA synthase
xref: UnificationXref4286
feature: FragmentFeature902
cellular location: GO_0005759
comment: Reactome DB_ID: 5580943
display name: HMGCS2

Signaling by constitutively active EGFR
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction105
evidence: Evidence204
xref: UnificationXref1726
xref: UnificationXref1725
pathway order: PathwayStep186
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219924
data source: Provenance1
name: hydroxymethylglutaryl-CoA synthase
name: Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
name: DDB0219924
name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
name: HMG-CoA synthase
xref: UnificationXref4288
feature: FragmentFeature903
cellular location: GO_0005759
comment: Reactome DB_ID: 5580947
display name: HMGCS2

3-hydroxy-3-methylglutarate-CoA lyase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230167
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0230167
name: Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
name: HMG-CoA lyase
name: hydroxymethylglutaryl-CoA lyase
name: HMGCL
xref: UnificationXref4296
feature: FragmentFeature904
cellular location: GO_0005759
comment: Reactome DB_ID: 5581126
display name: HL

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232044
data source: Provenance1
name: 3-hydroxybutyrate dehydrogenase
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase)
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
name: DDB0232044
xref: UnificationXref4303
feature: FragmentFeature905
cellular location: GO_0005759
comment: Reactome DB_ID: 5580930
display name: BDH1

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI_29159
data source: Provenance1
xref: UnificationXref12379
xref: UnificationXref12378
cellular location: GO_0005759
comment: Reactome DB_ID: 379759

Homologues of BDH1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0266928
xref: UnificationXref4305
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5580935

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI_16828
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref12377
xref: UnificationXref7517
cellular location: GO_0005759
comment: Reactome DB_ID: 379709
display name: L-Trp

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: CHEBI_17895
data source: Provenance1
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref12386
xref: UnificationXref12387
cellular location: GO_0005759
comment: Reactome DB_ID: 379710
display name: L-Tyr

tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI_29182
data source: Provenance1
xref: UnificationXref12384
xref: UnificationXref12385
cellular location: GO_0005759
comment: Reactome DB_ID: 379756

tRNA(Val)
type: SmallMolecule
entity reference: CHEBI_29183
data source: Provenance1
xref: UnificationXref12396
xref: UnificationXref12395
cellular location: GO_0005759
comment: Reactome DB_ID: 379735

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI_29161
data source: Provenance1
xref: UnificationXref12388
xref: UnificationXref12389
cellular location: GO_0005759
comment: Reactome DB_ID: 379755

transfer RNA
type: SmallMolecule
entity reference: CHEBI_17843
data source: Provenance1
xref: UnificationXref12478
xref: UnificationXref12479
cellular location: GO_0005829
comment: Reactome DB_ID: 141679
display name: tRNA

Val-tRNA(Val)
type: SmallMolecule
entity reference: CHEBI_29164
data source: Provenance1
xref: UnificationXref12398
xref: UnificationXref12397
cellular location: GO_0005759
comment: Reactome DB_ID: 379782

1,3-diaminopropane
type: SmallMolecule
entity reference: CHEBI_15725
data source: Provenance1
xref: UnificationXref12976
xref: UnificationXref12975
cellular location: GO_0005829
comment: Reactome DB_ID: 204628

Aminoacyl-tRNA
type: SmallMolecule
data source: Provenance1
member physical entity: Val-tRNA(Val)
member physical entity: Trp-tRNA(Trp)
member physical entity: Leu-tRNA(Leu)
member physical entity: Glu-tRNA(Glu)
member physical entity: Tyr-tRNA(Tyr)
member physical entity: Gln-tRNA(Gln)
member physical entity: Ser-tRNA(Ser)
member physical entity: Asp-tRNA(Asp)
member physical entity: Met-tRNA(Met)
member physical entity: Gly-tRNA(Gly)
member physical entity: Thr-tRNA(Thr)
member physical entity: Asn-tRNA(Asn)
member physical entity: Lys-tRNA(Lys)
member physical entity: His-tRNA(His)
member physical entity: Pro-tRNA(Pro)
member physical entity: Arg-tRNA(Arg)
member physical entity: Ile-tRNA(Ile)
member physical entity: Phe-tRNA(Phe)
member physical entity: Ala-tRNA(Ala)
member physical entity: Cys-tRNA(Cys)
xref: UnificationXref12754
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5582823

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233315
data source: Provenance1
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
name: DDB0233315
xref: UnificationXref4404
feature: FragmentFeature929
cellular location: GO_0005829
comment: Reactome DB_ID: 5584254
display name: TIAM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304693
data source: Provenance1
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
name: DDB0304693
xref: UnificationXref4402
feature: FragmentFeature928
cellular location: GO_0005829
comment: Reactome DB_ID: 5584253
display name: TIAM2

Homologues of TIAM2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0233357
xref: UnificationXref4415
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5584260

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215332
data source: Provenance1
name: Ral guanine nucleotide dissociation stimulator-like 1
name: DDB0215332
name: RGL1_HUMAN
xref: UnificationXref4397
feature: FragmentFeature927
cellular location: GO_0005829
comment: Reactome DB_ID: 5590578
display name: RGL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191326
data source: Provenance1
name: Ral guanine nucleotide dissociation stimulator-like 1
name: RGL1_HUMAN
name: DDB0191326
xref: UnificationXref4395
feature: FragmentFeature926
cellular location: GO_0005829
comment: Reactome DB_ID: 5590577
display name: RGL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233551
data source: Provenance1
name: DDB0233551
name: Ral guanine nucleotide dissociation stimulator-like 1
name: RGL1_HUMAN
xref: UnificationXref4393
feature: FragmentFeature925
cellular location: GO_0005829
comment: Reactome DB_ID: 5590576
display name: RGL1

DDB0231997
type: Protein
entity reference: UniProt:DDB0231997
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ral guanine nucleotide dissociation stimulator-like 1
name: RGL1_HUMAN
xref: UnificationXref4391
feature: FragmentFeature924
cellular location: GO_0005829
comment: Reactome DB_ID: 5590575
display name: RGL1

Homologues of RGL1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0231997
xref: UnificationXref4398
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5590579

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191268
data source: Provenance1
name: NADP-dependent malic enzyme
name: MAOX_HUMAN
name: DDB0191268
xref: UnificationXref4387
feature: FragmentFeature923
cellular location: GO_0005829
comment: Reactome DB_ID: 5590567
display name: ME1

Hydroxymethylglutaryl-CoA synthase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219924
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0219924
xref: UnificationXref4380
feature: FragmentFeature922
cellular location: GO_0005829
comment: Reactome DB_ID: 5583891
display name: HMGCS1

(Indol-3-yl)pyruvate
type: SmallMoleculeReference
name: ChEBI:29750 3-(indol-3-yl)pyruvic acid
name: Indolepyruvic acid
name: 3-(Indol-3-yl)pyruvate
name: Indole-3-pyruvate
name: Indolepyruvate
name: 3-(indol-3-yl)pyruvic acid
xref: UnificationXref7437

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235167
data source: Provenance1
name: DDB0235167
name: ANKR1_HUMAN
name: Ankyrin repeat domain-containing protein 1
xref: UnificationXref4376
feature: FragmentFeature920
cellular location: GO_0005654
comment: Reactome DB_ID: 5590586
display name: ANKRD1

ACSL1 variant1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191105
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0191105
xref: UnificationXref4372
feature: FragmentFeature919
cellular location: GO_0005741
comment: Reactome DB_ID: 5590581
display name: ACSL1

Hydroxymethylglutaryl-CoA synthase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0217522
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0217522
xref: UnificationXref4379
feature: FragmentFeature921
cellular location: GO_0005829
comment: Reactome DB_ID: 5583890
display name: HMGCS1

Homologues of HMGCS1
type: Protein
data source: Provenance1
member physical entity: Hydroxymethylglutaryl-CoA synthase
xref: UnificationXref4381
cellular location: GO_0005829
comment: Reactome DB_ID: 5583892
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201629
data source: Provenance1
name: MDR3_HUMAN
name: DDB0201629
name: Multidrug resistance protein 3
xref: UnificationXref4361
feature: FragmentFeature916
cellular location: GO_0005886
comment: Reactome DB_ID: 5590570
display name: ABCB4

Homologues of ABCB4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4364
cellular location: GO_0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5590572

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234154
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 1
name: DDB0234154
name: ACOX1 isoform 2
xref: UnificationXref4369
feature: FragmentFeature918
cellular location: GO_0005782
comment: Reactome DB_ID: 5586572
display name: ACOX1-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201670
data source: Provenance1
name: MDR3_HUMAN
name: DDB0201670
name: Multidrug resistance protein 3
xref: UnificationXref4363
feature: FragmentFeature917
cellular location: GO_0005886
comment: Reactome DB_ID: 5590571
display name: ABCB4

DDB0191125
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191125
data source: Provenance1
name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-1
name: Note: the coordinates are copied over from Homo sapiens.
name: HMDH_HUMAN
name: HMGCR isoform 1
xref: UnificationXref4356
feature: FragmentFeature915
cellular location: GO_0005789
comment: Reactome DB_ID: 5583902
display name: HMGCR-1

3-hydroxy-3-methylglutaryl-coenzyme A reductase-1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215357
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0215357
name: HMDH_HUMAN
name: HMGCR isoform 1
xref: UnificationXref4354
feature: FragmentFeature914
cellular location: GO_0005789
comment: Reactome DB_ID: 5583898
display name: HMGCR-1

http://identifiers.org/pubmed/17035228
type: PublicationXref
id: 17035228
author: Ron, D
author: Zilpa, T
author: Shabtay, A
author: Dym, N
author: Preger, E
author: Ziv, I
author: Harduf, H
author: Fuchs, Y
db: Pubmed
title: The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate
source: J Biol Chem 281:39225-35
year: 2006

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

http://identifiers.org/pubmed/9741684
type: PublicationXref
id: 9741684
author: Edwards, PA
author: Shell, BK
author: Greene, JM
author: Ericsson, J
author: Carter, KC
author: Florence, C
author: Duan, DR
db: Pubmed
title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
source: J Lipid Res 39:1731-9
year: 1998

http://identifiers.org/pubmed/10212142
type: PublicationXref
id: 10212142
author: High, S
author: Greenfield, JJ
db: Pubmed
title: The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment
source: J Cell Sci 112:1477-86
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234095
data source: Provenance1
name: Peroxisomal membrane protein PMP34
name: DDB0234095
name: SLC25A17
xref: UnificationXref4430
feature: FragmentFeature935
cellular location: GO_0005778
comment: Reactome DB_ID: 5586354
display name: PMP34

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233496
data source: Provenance1
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
name: DDB0233496
xref: UnificationXref4414
feature: FragmentFeature934
cellular location: GO_0005829
comment: Reactome DB_ID: 5584259
display name: TIAM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234154
data source: Provenance1
name: DDB0234154
name: Acyl-coenzyme A oxidase 2, peroxisomal
xref: UnificationXref4467
feature: FragmentFeature937
cellular location: GO_0005782
comment: Reactome DB_ID: 5583974
display name: ACOX2

2-hydroxyphytanoyl-CoA lyase
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305141
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0305141
name: 2-hydroxyacyl-CoA lyase 1
xref: UnificationXref4446
feature: FragmentFeature936
cellular location: GO_0005782
comment: Reactome DB_ID: 5586346
display name: HACL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234155
data source: Provenance1
name: Peroxisomal acyl-coenzyme A oxidase 3
name: DDB0234155
xref: UnificationXref4472
feature: FragmentFeature938
cellular location: GO_0005782
comment: Reactome DB_ID: 5586400
display name: ACOX3

Homologues of ACOX3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4481
cellular location: GO_0005782
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586417

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233494
data source: Provenance1
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
name: DDB0233494
xref: UnificationXref4408
feature: FragmentFeature931
cellular location: GO_0005829
comment: Reactome DB_ID: 5584256
display name: TIAM2

DDB0233357
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233357
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
xref: UnificationXref4406
feature: FragmentFeature930
cellular location: GO_0005829
comment: Reactome DB_ID: 5584255
display name: TIAM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233314
data source: Provenance1
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
name: DDB0233314
xref: UnificationXref4412
feature: FragmentFeature933
cellular location: GO_0005829
comment: Reactome DB_ID: 5584258
display name: TIAM2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233358
data source: Provenance1
name: DDB0233358
name: TIAM2_HUMAN
name: T-lymphoma invasion and metastasis-inducing protein 2
xref: UnificationXref4410
feature: FragmentFeature932
cellular location: GO_0005829
comment: Reactome DB_ID: 5584257
display name: TIAM2

http://identifiers.org/pubmed/10101268
type: PublicationXref
id: 10101268
author: Heilmeyer LM, Jr
author: Gehrmann, T
author: Balla, A
author: Herberg, FW
author: Mayr, Georg W
author: Suer, S
author: Gülkan, H
author: Vereb, G
db: Pubmed
title: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230
source: Biochim Biophys Acta 1437:341-56
year: 1999

UniProt:DDB0231755
type: ProteinReference
xref: UnificationXref75
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231753
type: ProteinReference
xref: UnificationXref6
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231750
type: ProteinReference
xref: UnificationXref5148
organism: http://identifiers.org/taxonomy/44689

Golgi Cisternae Pericentriolar Stack Reorganization
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction854
evidence: Evidence1250
xref: UnificationXref8568
xref: UnificationXref8567
pathway order: PathwayStep1228
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4101
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4100
type: SequenceSite
position status: EQUAL
sequence position: 782

SequenceSite4105
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4104
type: SequenceSite
position status: EQUAL
sequence position: 548

SequenceSite4103
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231749
type: ProteinReference
xref: UnificationXref7883
organism: http://identifiers.org/taxonomy/44689

SequenceSite4102
type: SequenceSite
position status: EQUAL
sequence position: 462

http://identifiers.org/pubmed/11322953
type: PublicationXref
id: 11322953
author: Ishida, N
author: Kawakita, M
author: Muraoka, M
db: Pubmed
title: Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
source: FEBS Lett 495:87-93
year: 2001

UniProt:DDB0231726
type: ProteinReference
xref: UnificationXref8720
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231727
type: ProteinReference
xref: UnificationXref7354
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231721
type: ProteinReference
xref: UnificationXref10486
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231724
type: ProteinReference
xref: UnificationXref13028
organism: http://identifiers.org/taxonomy/44689

SequenceSite4131
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4132
type: SequenceSite
position status: EQUAL
sequence position: 756

SequenceSite4133
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4134
type: SequenceSite
position status: EQUAL
sequence position: 862

SequenceSite4135
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4136
type: SequenceSite
position status: EQUAL
sequence position: 846

SequenceSite4137
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4138
type: SequenceSite
position status: EQUAL
sequence position: 1137

SequenceSite4130
type: SequenceSite
position status: EQUAL
sequence position: 934

phagocytic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref1461

synaptic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref10115

UniProt:DDB0231711
type: ProteinReference
xref: UnificationXref8191
organism: http://identifiers.org/taxonomy/44689

SequenceSite4129
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4128
type: SequenceSite
position status: EQUAL
sequence position: 1360

UniProt:DDB0231714
type: ProteinReference
xref: UnificationXref7650
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231710
type: ProteinReference
xref: UnificationXref3885
organism: http://identifiers.org/taxonomy/44689

SequenceSite4144
type: SequenceSite
position status: EQUAL
sequence position: 1970

SequenceSite4145
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4142
type: SequenceSite
position status: EQUAL
sequence position: 156

UniProt:DDB0231708
type: ProteinReference
xref: UnificationXref13011
organism: http://identifiers.org/taxonomy/44689

SequenceSite4143
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4148
type: SequenceSite
position status: EQUAL
sequence position: 439

SequenceSite4149
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4146
type: SequenceSite
position status: EQUAL
sequence position: 316

SequenceSite4147
type: SequenceSite
position status: EQUAL
sequence position: 2

secretory granule membrane
type: CellularLocationVocabulary
xref: UnificationXref10123

SequenceSite4140
type: SequenceSite
position status: EQUAL
sequence position: 790

SequenceSite4141
type: SequenceSite
position status: EQUAL
sequence position: 1

Golgi-associated vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref9656

SequenceSite4139
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4113
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4114
type: SequenceSite
position status: EQUAL
sequence position: 916

SequenceSite4115
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4116
type: SequenceSite
position status: EQUAL
sequence position: 297

SequenceSite4110
type: SequenceSite
position status: EQUAL
sequence position: 395

SequenceSite4111
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11459976
type: PublicationXref
id: 11459976
author: Bell, SP
author: Klemm, RD
db: Pubmed
title: ATP bound to the origin recognition complex is important for preRC formation.
source: Proc Natl Acad Sci U S A 98:8361-7
year: 2001

SequenceSite4112
type: SequenceSite
position status: EQUAL
sequence position: 1186

SequenceSite4107
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4106
type: SequenceSite
position status: EQUAL
sequence position: 308

SequenceSite4109
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4108
type: SequenceSite
position status: EQUAL
sequence position: 760

SequenceSite4126
type: SequenceSite
position status: EQUAL
sequence position: 1328

SequenceSite4127
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4124
type: SequenceSite
position status: EQUAL
sequence position: 1471

SequenceSite4125
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4122
type: SequenceSite
position status: EQUAL
sequence position: 855

SequenceSite4123
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4120
type: SequenceSite
position status: EQUAL
sequence position: 396

SequenceSite4121
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4119
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4118
type: SequenceSite
position status: EQUAL
sequence position: 1493

SequenceSite4117
type: SequenceSite
position status: EQUAL
sequence position: 1

GPVI-mediated activation cascade
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction51
pathway component: BiochemicalReaction45
evidence: Evidence112
xref: UnificationXref849
xref: UnificationXref850
pathway order: PathwayStep86
pathway order: PathwayStep99
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/22178396
type: PublicationXref
id: 22178396
author: Anderton, Emma
author: Shinkai, Y
author: Kuninaka, Shinji
author: Saya, H
author: Imai, Yoshinori
author: Peters, Gordon
author: Hara, Eiji
author: Yamakoshi, Kimi
author: Yoshimoto, Shin
author: Takeuchi, Takashi
author: Ohtani, Naoko
author: Takahashi, Akiko
author: Hori, Satoshi
author: Tachibana, M
db: Pubmed
title: DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
source: Mol. Cell 45:123-31
year: 2012

UnificationXref12060
type: UnificationXref
id: CHEBI:29265
db: ChEBI

http://identifiers.org/pubmed/9844003
type: PublicationXref
id: 9844003
author: Leonhard, S
author: Bittiger, H
author: Pfaff, T
author: Kaupmann, K
author: Bettler, B
author: Karschin, A
author: Froestl, W
author: Schuler, V
author: Bischoff, S
author: Heid, J
author: Mosbacher, J
db: Pubmed
title: Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels
source: Proc Natl Acad Sci U S A 95:14991-6
year: 1998

UnificationXref12061
type: UnificationXref
id: 379728
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379728

SequenceSite4062
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12052
type: UnificationXref
id: DDB0231317
db: UniProt

SequenceSite4061
type: SequenceSite
position status: EQUAL
sequence position: 633

UnificationXref12051
type: UnificationXref
id: 5585854
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585854

SequenceSite4064
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12054
type: UnificationXref
id: 5585875
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585875

SequenceSite4063
type: SequenceSite
position status: EQUAL
sequence position: 380

UnificationXref12053
type: UnificationXref
id: 5585845
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585845

UnificationXref12056
type: UnificationXref
id: REACT_229472
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229472.1

UnificationXref12055
type: UnificationXref
id: 5585923
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585923

SequenceSite4060
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12058
type: UnificationXref
id: 379722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379722

UnificationXref12057
type: UnificationXref
id: CHEBI:29172
db: ChEBI

SequenceSite4069
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12059
type: UnificationXref
id: REACT_15652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15652.1

SequenceSite4066
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4065
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite4068
type: SequenceSite
position status: EQUAL
sequence position: 145

SequenceSite4067
type: SequenceSite
position status: EQUAL
sequence position: 207

Cytosolic tRNA aminoacylation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1229
pathway component: BiochemicalReaction1238
pathway component: BiochemicalReaction1239
pathway component: BiochemicalReaction1227
pathway component: BiochemicalReaction1240
pathway component: BiochemicalReaction1228
pathway component: BiochemicalReaction1241
pathway component: BiochemicalReaction1234
pathway component: BiochemicalReaction1242
pathway component: BiochemicalReaction1235
pathway component: BiochemicalReaction1243
pathway component: BiochemicalReaction1236
pathway component: BiochemicalReaction1244
pathway component: BiochemicalReaction1237
pathway component: BiochemicalReaction1246
pathway component: BiochemicalReaction1231
pathway component: BiochemicalReaction1245
pathway component: BiochemicalReaction1230
pathway component: BiochemicalReaction1233
pathway component: BiochemicalReaction1232
pathway component: BiochemicalReaction1174
evidence: Evidence1898
xref: UnificationXref12231
xref: UnificationXref12230
xref: RelationshipXref1574
pathway order: PathwayStep1770
pathway order: PathwayStep1849
pathway order: PathwayStep1848
pathway order: PathwayStep1860
pathway order: PathwayStep1861
pathway order: PathwayStep1859
pathway order: PathwayStep1845
pathway order: PathwayStep1858
pathway order: PathwayStep1844
pathway order: PathwayStep1857
pathway order: PathwayStep1856
pathway order: PathwayStep1847
pathway order: PathwayStep1855
pathway order: PathwayStep1846
pathway order: PathwayStep1854
pathway order: PathwayStep1853
pathway order: PathwayStep1852
pathway order: PathwayStep1843
pathway order: PathwayStep1842
pathway order: PathwayStep1851
pathway order: PathwayStep1850
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/11459989
type: PublicationXref
id: 11459989
author: Paulusma, C
author: Wyman, C
author: Kanaar, R
author: Ristic, D
db: Pubmed
title: The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.
source: Proc Natl Acad Sci U S A 98:8454-60
year: 2001

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

UnificationXref12071
type: UnificationXref
id: 379707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379707

UnificationXref12072
type: UnificationXref
id: REACT_15677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15677.1

(1R-cis)-2-amino-1,9-dihydro-9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one
type: SmallMoleculeReference
name: (-)-carbovir
name: carbovir
name: CBV
name: 2-amino-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-9H-purin-6-ol
name: (-)-carbovir [ChEBI:421843]
xref: UnificationXref8456

UnificationXref12070
type: UnificationXref
id: CHEBI:29158
db: ChEBI

SequenceSite4053
type: SequenceSite
position status: EQUAL
sequence position: 350

UnificationXref12065
type: UnificationXref
id: 5585931
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585931

SequenceSite4052
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12064
type: UnificationXref
id: 5585929
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585929

SequenceSite4051
type: SequenceSite
position status: EQUAL
sequence position: 345

UnificationXref12063
type: UnificationXref
id: DDB0231333
db: UniProt

SequenceSite4050
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12062
type: UnificationXref
id: REACT_15840
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15840.1

UnificationXref12069
type: UnificationXref
id: REACT_15890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15890.1

UnificationXref12068
type: UnificationXref
id: 379711
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379711

UnificationXref12067
type: UnificationXref
id: CHEBI:29186
db: ChEBI

UnificationXref12066
type: UnificationXref
id: REACT_216314
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_216314.2

SequenceSite4059
type: SequenceSite
position status: EQUAL
sequence position: 1009

SequenceSite4058
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4057
type: SequenceSite
position status: EQUAL
sequence position: 335

SequenceSite4056
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4055
type: SequenceSite
position status: EQUAL
sequence position: 312

SequenceSite4054
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12080
type: UnificationXref
id: REACT_15780
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15780.1

UnificationXref12081
type: UnificationXref
id: DDB0231318
db: UniProt

http://identifiers.org/pubmed/19373259
type: PublicationXref
id: 19373259
author: Pauli, Silke
author: Koch, HG
author: Linnebank, Michael
author: Häberle, Johannes
author: Berning, Christoph
db: Pubmed
title: TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations
source: J. Hum. Genet. 54:331-4
year: 2009

UnificationXref12082
type: UnificationXref
id: 5585891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585891

UnificationXref12083
type: UnificationXref
id: 5585892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585892

UnificationXref12078
type: UnificationXref
id: CHEBI:29152
db: ChEBI

UnificationXref12077
type: UnificationXref
id: REACT_15645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15645.1

UnificationXref12079
type: UnificationXref
id: 379719
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379719

SequenceSite4040
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12074
type: UnificationXref
id: REACT_252300
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252300.1

UnificationXref12073
type: UnificationXref
id: 5585887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585887

SequenceSite4042
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12076
type: UnificationXref
id: 379725
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379725

SequenceSite4041
type: SequenceSite
position status: EQUAL
sequence position: 381

UnificationXref12075
type: UnificationXref
id: CHEBI:29167
db: ChEBI

SequenceSite4044
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/20198122
type: PublicationXref
id: 20198122
author: La Cava, Antonio
author: Matarese, Giuseppe
author: Lam, Queenie Lai Kwan
author: Lu, Liwei
author: Iikuni, Noriko
db: Pubmed
title: Leptin and Inflammation
source: Curr Immunol Rev 4:70-79
year: 2008

SequenceSite4043
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite4046
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4045
type: SequenceSite
position status: EQUAL
sequence position: 381

http://identifiers.org/pubmed/11250913
type: PublicationXref
id: 11250913
author: Podust, VN
author: Dianov, GL
author: Bohr, VA
author: Podlutsky, AJ
author: Dianova, II
db: Pubmed
title: Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.
source: EMBO J 20:1477-82
year: 2001

SequenceSite4048
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4047
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite4049
type: SequenceSite
position status: EQUAL
sequence position: 546

UniProt:DDB0219484
type: ProteinReference
xref: UnificationXref5511
organism: http://identifiers.org/taxonomy/44689

SequenceSite4029
type: SequenceSite
position status: EQUAL
sequence position: 355

UnificationXref12093
type: UnificationXref
id: REACT_246350
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246350.1

UnificationXref12094
type: UnificationXref
id: CHEBI:29168
db: ChEBI

http://identifiers.org/pubmed/18022816
type: PublicationXref
id: 18022816
author: Garcia, S
author: López-Colomé, AM
author: López, E
db: Pubmed
title: Glutamate accelerates RPE cell proliferation through ERK1/2 activation via distinct receptor-specific mechanisms
source: J Cell Biochem 104:377-90
year: 2008

UnificationXref12091
type: UnificationXref
id: REACT_16052
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16052.1

UnificationXref12092
type: UnificationXref
id: 5585877
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585877

UnificationXref12090
type: UnificationXref
id: 379751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379751

UnificationXref12089
type: UnificationXref
id: CHEBI:29157
db: ChEBI

UnificationXref12088
type: UnificationXref
id: REACT_16086
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16086.1

transport vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref3925

SequenceSite4031
type: SequenceSite
position status: EQUAL
sequence position: 355

UnificationXref12087
type: UnificationXref
id: 379778
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379778

SequenceSite4030
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref12086
type: UnificationXref
id: CHEBI:29175
db: ChEBI

UnificationXref12085
type: UnificationXref
id: REACT_215319
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215319.2

cytoplasmic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref9726

UnificationXref12084
type: UnificationXref
id: 5585894
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585894

SequenceSite4035
type: SequenceSite
position status: EQUAL
sequence position: 355

SequenceSite4034
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4033
type: SequenceSite
position status: EQUAL
sequence position: 355

SequenceSite4032
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4039
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite4038
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4037
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite4036
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231789
type: ProteinReference
xref: UnificationXref9911
organism: http://identifiers.org/taxonomy/44689

UnificationXref12015
type: UnificationXref
id: REACT_210690
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210690.2

UnificationXref12016
type: UnificationXref
id: CHEBI:17732
db: ChEBI

UnificationXref12017
type: UnificationXref
id: 379731
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379731

UnificationXref12018
type: UnificationXref
id: REACT_17504
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17504.1

UnificationXref12019
type: UnificationXref
id: 379700
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379700

UnificationXref12010
type: UnificationXref
id: 5592484
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592484

UnificationXref12011
type: UnificationXref
id: REACT_223023
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223023.2

UnificationXref12012
type: UnificationXref
id: 5592485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592485

UnificationXref12013
type: UnificationXref
id: REACT_222000
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222000.2

UnificationXref12014
type: UnificationXref
id: 5592486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592486

UnificationXref12028
type: UnificationXref
id: CHEBI:18366
db: ChEBI

UnificationXref12029
type: UnificationXref
id: 379720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379720

SUMO is proteolytically processed
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1371
pathway component: BiochemicalReaction1372
pathway component: BiochemicalReaction1370
evidence: Evidence2082
xref: UnificationXref13530
xref: RelationshipXref1711
xref: UnificationXref13529
pathway order: PathwayStep2043
pathway order: PathwayStep2044
pathway order: PathwayStep2042
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12026
type: UnificationXref
id: 379704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379704

UnificationXref12027
type: UnificationXref
id: REACT_17645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17645.1

SequenceSite4098
type: SequenceSite
position status: EQUAL
sequence position: 1140

SequenceSite4099
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4096
type: SequenceSite
position status: EQUAL
sequence position: 409

UnificationXref12020
type: UnificationXref
id: REACT_17687
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17687.1

SequenceSite4097
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12021
type: UnificationXref
id: DDB0214894
db: UniProt

SequenceSite4094
type: SequenceSite
position status: EQUAL
sequence position: 940

SequenceSite4095
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4092
type: SequenceSite
position status: EQUAL
sequence position: 4128

UnificationXref12024
type: UnificationXref
id: REACT_211274
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211274.2

SequenceSite4093
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref12025
type: UnificationXref
id: CHEBI:29171
db: ChEBI

SequenceSite4090
type: SequenceSite
position status: EQUAL
sequence position: 4128

UnificationXref12022
type: UnificationXref
id: 5585881
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585881

SequenceSite4091
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12023
type: UnificationXref
id: 5585883
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585883

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

SequenceSite4087
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4088
type: SequenceSite
position status: EQUAL
sequence position: 609

SequenceSite4089
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12037
type: UnificationXref
id: DDB0231297
db: UniProt

UnificationXref12038
type: UnificationXref
id: 5585862
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585862

UnificationXref12039
type: UnificationXref
id: DDB0231325
db: UniProt

UnificationXref12033
type: UnificationXref
id: DDB0231258
db: UniProt

SequenceSite4080
type: SequenceSite
position status: EQUAL
sequence position: 3418

UnificationXref12034
type: UnificationXref
id: 5585849
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585849

SequenceSite4081
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12035
type: UnificationXref
id: DDB0201644
db: UniProt

SequenceSite4082
type: SequenceSite
position status: EQUAL
sequence position: 418

UnificationXref12036
type: UnificationXref
id: 5585866
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585866

SequenceSite4083
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4084
type: SequenceSite
position status: EQUAL
sequence position: 418

UnificationXref12030
type: UnificationXref
id: REACT_15727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15727.1

SequenceSite4085
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref12031
type: UnificationXref
id: DDB0231253
db: UniProt

SequenceSite4086
type: SequenceSite
position status: EQUAL
sequence position: 732

UnificationXref12032
type: UnificationXref
id: 5585858
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585858

UnificationXref12050
type: UnificationXref
id: 5585853
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585853

UniProt:DDB0231779
type: ProteinReference
xref: UnificationXref8955
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231777
type: ProteinReference
xref: UnificationXref69
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

UniProt:DDB0231776
type: ProteinReference
xref: UnificationXref9095
organism: http://identifiers.org/taxonomy/44689

SequenceSite4078
type: SequenceSite
position status: EQUAL
sequence position: 339

SequenceSite4079
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4076
type: SequenceSite
position status: EQUAL
sequence position: 339

SequenceSite4077
type: SequenceSite
position status: EQUAL
sequence position: 1

Regulation of APC/C activators between G1/S and early anaphase
type: Pathway
data source: Provenance1
pathway component: REACT 206233.2
pathway component: REACT 259607.1
pathway component: BiochemicalReaction944
pathway component: BiochemicalReaction945
evidence: Evidence1423
xref: UnificationXref9400
xref: UnificationXref9399
xref: RelationshipXref1318
pathway order: PathwayStep1398
pathway order: PathwayStep1303
pathway order: PathwayStep1395
pathway order: PathwayStep1394
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12048
type: UnificationXref
id: 5585870
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585870

UnificationXref12049
type: UnificationXref
id: DDB0231263
db: UniProt

SequenceSite4070
type: SequenceSite
position status: EQUAL
sequence position: 207

UnificationXref12046
type: UnificationXref
id: 5585841
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585841

SequenceSite4071
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12047
type: UnificationXref
id: DDB0231298
db: UniProt

UnificationXref12044
type: UnificationXref
id: 5585839
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585839

UnificationXref12045
type: UnificationXref
id: 5585840
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585840

SequenceSite4074
type: SequenceSite
position status: EQUAL
sequence position: 708

UnificationXref12042
type: UnificationXref
id: 5585835
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585835

SequenceSite4075
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12043
type: UnificationXref
id: DDB0231308
db: UniProt

SequenceSite4072
type: SequenceSite
position status: EQUAL
sequence position: 1312

UnificationXref12040
type: UnificationXref
id: 5585874
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585874

SequenceSite4073
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12041
type: UnificationXref
id: DDB0231309
db: UniProt

tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI_29185
data source: Provenance1
xref: UnificationXref12141
xref: UnificationXref12140
cellular location: GO_0005829
comment: Reactome DB_ID: 379776

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI_16624
data source: Provenance1
xref: UnificationXref12135
xref: UnificationXref12136
cellular location: GO_0005829
comment: Reactome DB_ID: 379757

tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI_29184
data source: Provenance1
xref: UnificationXref12156
xref: UnificationXref12157
cellular location: GO_0005829
comment: Reactome DB_ID: 379767

Met-tRNA(Met)
type: SmallMolecule
entity reference: CHEBI_16635
data source: Provenance1
xref: UnificationXref12151
xref: UnificationXref12152
cellular location: GO_0005829
comment: Reactome DB_ID: 379794

tRNA(Met)
type: SmallMolecule
entity reference: CHEBI_29173
data source: Provenance1
xref: UnificationXref12149
xref: UnificationXref12148
cellular location: GO_0005829
comment: Reactome DB_ID: 379742

http://identifiers.org/pubmed/23599745
type: PublicationXref
id: 23599745
author: Hamid, Abdu Selim
author: Tesfamariam, Isaias Goitom
author: Zhang, Zhen Gui
author: Zhang, Yucheng
db: Pubmed
title: Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention
source: Oncol Lett 5:1087-1092
year: 2013

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI_16047
data source: Provenance1
xref: UnificationXref12143
xref: UnificationXref12144
cellular location: GO_0005829
comment: Reactome DB_ID: 379736

tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI_29179
data source: Provenance1
xref: UnificationXref12177
xref: UnificationXref12178
cellular location: GO_0005829
comment: Reactome DB_ID: 379762

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI_29154
data source: Provenance1
xref: UnificationXref12173
xref: UnificationXref12172
cellular location: GO_0005829
comment: Reactome DB_ID: 379746

tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI_29177
data source: Provenance1
xref: UnificationXref12170
xref: UnificationXref12169
cellular location: GO_0005829
comment: Reactome DB_ID: 379768

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI_29153
data source: Provenance1
xref: UnificationXref12160
xref: UnificationXref12159
cellular location: GO_0005829
comment: Reactome DB_ID: 379792

tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI_29169
data source: Provenance1
xref: UnificationXref12132
xref: UnificationXref12133
cellular location: GO_0005829
comment: Reactome DB_ID: 379771

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI_29157
data source: Provenance1
xref: UnificationXref12091
xref: UnificationXref12090
cellular location: GO_0005829
comment: Reactome DB_ID: 379751

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI_29166
data source: Provenance1
xref: UnificationXref12099
xref: UnificationXref12098
cellular location: GO_0005829
comment: Reactome DB_ID: 379772

tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI_29168
data source: Provenance1
xref: UnificationXref12095
xref: UnificationXref12096
cellular location: GO_0005829
comment: Reactome DB_ID: 379748

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI_29156
data source: Provenance1
xref: UnificationXref12106
xref: UnificationXref12107
cellular location: GO_0005829
comment: Reactome DB_ID: 379784

tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI_29176
data source: Provenance1
xref: UnificationXref12104
xref: UnificationXref12103
cellular location: GO_0005829
comment: Reactome DB_ID: 379766

His-tRNA(His)
type: SmallMolecule
entity reference: CHEBI_29155
data source: Provenance1
xref: UnificationXref12118
xref: UnificationXref12117
cellular location: GO_0005829
comment: Reactome DB_ID: 379786

tRNA(His)
type: SmallMolecule
entity reference: CHEBI_29178
data source: Provenance1
xref: UnificationXref12115
xref: UnificationXref12114
cellular location: GO_0005829
comment: Reactome DB_ID: 379758

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI_29160
data source: Provenance1
xref: UnificationXref12128
xref: UnificationXref12127
cellular location: GO_0005829
comment: Reactome DB_ID: 379787

tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI_29174
data source: Provenance1
xref: UnificationXref12125
xref: UnificationXref12124
cellular location: GO_0005829
comment: Reactome DB_ID: 379739

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI_29152
data source: Provenance1
xref: UnificationXref12079
xref: UnificationXref12080
cellular location: GO_0005829
comment: Reactome DB_ID: 379719

tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI_29175
data source: Provenance1
xref: UnificationXref12088
xref: UnificationXref12087
cellular location: GO_0005829
comment: Reactome DB_ID: 379778

http://identifiers.org/pubmed/7596435
type: PublicationXref
id: 7596435
author: Rossant, J
author: Shalaby, F
author: Gertsenstein, M
author: Schuh, A C
author: Yamaguchi, T P
author: Breitman, M L
author: Wu, X F
db: Pubmed
title: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
source: Nature 376:62-6
year: 1995

tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI_29167
data source: Provenance1
xref: UnificationXref12077
xref: UnificationXref12076
cellular location: GO_0005829
comment: Reactome DB_ID: 379725

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI_29158
data source: Provenance1
xref: UnificationXref12071
xref: UnificationXref12072
cellular location: GO_0005829
comment: Reactome DB_ID: 379707

tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI_29186
data source: Provenance1
xref: UnificationXref12069
xref: UnificationXref12068
cellular location: GO_0005829
comment: Reactome DB_ID: 379711

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: ChEBI:29265 Asn-tRNA(Asn)
data source: Provenance1
xref: UnificationXref12062
xref: UnificationXref12061
cellular location: GO_0005829
comment: Reactome DB_ID: 379728

tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI_29172
data source: Provenance1
xref: UnificationXref12058
xref: UnificationXref12059
cellular location: GO_0005829
comment: Reactome DB_ID: 379722

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI_18366
data source: Provenance1
xref: UnificationXref12029
xref: UnificationXref12030
cellular location: GO_0005829
comment: Reactome DB_ID: 379720

tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI_29171
data source: Provenance1
xref: UnificationXref12026
xref: UnificationXref12027
cellular location: GO_0005829
comment: Reactome DB_ID: 379704

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI_17732
data source: Provenance1
xref: UnificationXref12019
xref: UnificationXref12020
cellular location: GO_0005829
comment: Reactome DB_ID: 379700

tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI_17732
data source: Provenance1
xref: UnificationXref12017
xref: UnificationXref12018
cellular location: GO_0005829
comment: Reactome DB_ID: 379731

Reactive oxygen species
type: SmallMolecule
entity reference: CHEBI_26523
data source: Provenance1
xref: UnificationXref11677
xref: UnificationXref11678
cellular location: GO_0005829
comment: Reactome DB_ID: 1250243
display name: ROS

http://identifiers.org/pubmed/16790503
type: PublicationXref
id: 16790503
author: Subramanian, VS
author: Marchant, JS
author: Said, HM
db: Pubmed
title: Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
source: Am J Physiol Cell Physiol 291:C851-9
year: 2006

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI_17345
data source: Provenance1
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref11722
xref: UnificationXref11723
cellular location: GO_0005654
comment: Reactome DB_ID: 29626
display name: GMP

http://identifiers.org/pubmed/12438414
type: PublicationXref
id: 12438414
author: Michael, WM
author: Van Hatten, RA
author: Holway, AH
author: Tutter, AV
author: Khederian, AM
author: Walter, JC
db: Pubmed
title: The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.
source: J Cell Biol 159:541-7
year: 2002

UnificationXref12001
type: UnificationXref
id: REACT_202745
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202745.2

UnificationXref12000
type: UnificationXref
id: 5592483
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592483

UnificationXref12003
type: UnificationXref
id: REACT_226094
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226094.2

UnificationXref12002
type: UnificationXref
id: 5592480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592480

http://identifiers.org/pubmed/9251237
type: PublicationXref
id: 9251237
author: Gallagher, JT
author: Stringer, SE
db: Pubmed
title: Heparan sulphate
source: Int J Biochem Cell Biol 29:709-14
year: 1997

Nitrite
type: SmallMolecule
entity reference: CHEBI_16301
data source: Provenance1
xref: UnificationXref11561
xref: UnificationXref11562
cellular location: GO_0005829
comment: Reactome DB_ID: 1222379

UnificationXref12009
type: UnificationXref
id: REACT_32237
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32237.5

Peroxynitrite
type: SmallMolecule
entity reference: CHEBI_25941
data source: Provenance1
xref: UnificationXref11558
xref: UnificationXref11559
cellular location: GO_0005829
comment: Reactome DB_ID: 1222481
display name: ONOO-

UnificationXref12008
type: UnificationXref
id: 5581919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581919

Nitrite
type: SmallMolecule
entity reference: CHEBI_16301
data source: Provenance1
xref: UnificationXref11567
xref: UnificationXref11568
cellular location: GO_0005759
comment: Reactome DB_ID: 3697842

Peroxynitrite
type: SmallMolecule
entity reference: CHEBI_25941
data source: Provenance1
xref: UnificationXref11565
xref: UnificationXref11566
cellular location: GO_0005759
comment: Reactome DB_ID: 3697881
display name: ONOO-

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMolecule
entity reference: CHEBI_16856
data source: Provenance1
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
xref: UnificationXref11512
xref: UnificationXref11513
cellular location: GO_0005759
comment: Reactome DB_ID: 1655887
display name: GSH

UnificationXref12005
type: UnificationXref
id: 77601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77601

UnificationXref12004
type: UnificationXref
id: 5581917
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581917

ferroheme
type: SmallMolecule
entity reference: CHEBI_38573
data source: Provenance1
xref: UnificationXref11541
xref: UnificationXref11540
cellular location: GO_0005743
comment: Reactome DB_ID: 3341317

UnificationXref12007
type: UnificationXref
id: 5581918
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581918

ferriheme
type: SmallMolecule
entity reference: CHEBI_38574
data source: Provenance1
xref: UnificationXref11536
xref: UnificationXref11535
cellular location: GO_0005743
comment: Reactome DB_ID: 3341371

UnificationXref12006
type: UnificationXref
id: REACT_4094
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4094.2

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI_17295
data source: Provenance1
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref12338
xref: UnificationXref1827
cellular location: GO_0005759
comment: Reactome DB_ID: 379701
display name: L-Phe

tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI_29184
data source: Provenance1
xref: UnificationXref12339
xref: UnificationXref12340
cellular location: GO_0005759
comment: Reactome DB_ID: 379760

L-Methionine
type: SmallMolecule
entity reference: CHEBI_16643
data source: Provenance1
xref: UnificationXref2201
xref: UnificationXref12331
cellular location: GO_0005759
comment: Reactome DB_ID: 379705
display name: L-Met

Met-tRNA(Met)
type: SmallMolecule
entity reference: CHEBI_16635
data source: Provenance1
xref: UnificationXref12332
xref: UnificationXref12333
cellular location: GO_0005759
comment: Reactome DB_ID: 379780

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI_29160
data source: Provenance1
xref: UnificationXref12308
xref: UnificationXref12307
cellular location: GO_0005759
comment: Reactome DB_ID: 379769

tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI_29169
data source: Provenance1
xref: UnificationXref12313
xref: UnificationXref12314
cellular location: GO_0005759
comment: Reactome DB_ID: 379788

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI_16047
data source: Provenance1
xref: UnificationXref12324
xref: UnificationXref12323
cellular location: GO_0005759
comment: Reactome DB_ID: 379795

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

tRNA(Met)
type: SmallMolecule
entity reference: CHEBI_29173
data source: Provenance1
xref: UnificationXref12329
xref: UnificationXref12330
cellular location: GO_0005759
comment: Reactome DB_ID: 379741

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI_16624
data source: Provenance1
xref: UnificationXref12316
xref: UnificationXref12315
cellular location: GO_0005759
comment: Reactome DB_ID: 379773

http://identifiers.org/pubmed/9593755
type: PublicationXref
id: 9593755
author: Garber, Ellen A
author: Miatkowski, Konrad
author: Wang, Elizabeth A
author: Baker, Darren P
author: Bixler, Sarah A
author: Rayhorn, Paul
author: Williams, Kevin P
author: Ambrose, Christine M
author: Pepinsky, R Blake
author: Zeng, Chenhui
author: Wen, Dingyi
author: Taylor, Frederick R
author: Galdes, Alphonse
db: Pubmed
title: Identification of a palmitic acid-modified form of human Sonic hedgehog
source: J. Biol. Chem. 273:14037-45
year: 1998

tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI_29185
data source: Provenance1
xref: UnificationXref12322
xref: UnificationXref12321
cellular location: GO_0005759
comment: Reactome DB_ID: 379747

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI_29156
data source: Provenance1
xref: UnificationXref12292
xref: UnificationXref12291
cellular location: GO_0005759
comment: Reactome DB_ID: 379781

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI_15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref7350
xref: UnificationXref12297
cellular location: GO_0005759
comment: Reactome DB_ID: 379695
display name: L-His

tRNA(His)
type: SmallMolecule
entity reference: CHEBI_29178
data source: Provenance1
xref: UnificationXref12298
xref: UnificationXref12299
cellular location: GO_0005759
comment: Reactome DB_ID: 379752

His-tRNA(His)
type: SmallMolecule
entity reference: CHEBI_29155
data source: Provenance1
xref: UnificationXref12300
xref: UnificationXref12301
cellular location: GO_0005759
comment: Reactome DB_ID: 379764

tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI_29174
data source: Provenance1
xref: UnificationXref12306
xref: UnificationXref12305
cellular location: GO_0005759
comment: Reactome DB_ID: 379750

Long-chain-fatty-acid--CoA ligase 6
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191105
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0191105
xref: UnificationXref4001
feature: FragmentFeature861
cellular location: GO_0005789
comment: Reactome DB_ID: 5587913
display name: ACSL6

Homologues of ELOVL1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4011
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587934

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252837
data source: Provenance1
name: Elongation of very long chain fatty acids protein 1
name: DDB0252837
xref: UnificationXref4008
feature: FragmentFeature862
cellular location: GO_0005789
comment: Reactome DB_ID: 5587932
display name: ELOVL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216761
data source: Provenance1
name: Elongation of very long chain fatty acids protein 1
name: DDB0216761
xref: UnificationXref4010
feature: FragmentFeature863
cellular location: GO_0005789
comment: Reactome DB_ID: 5587933
display name: ELOVL1

tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI_29175
data source: Provenance1
xref: UnificationXref12275
xref: UnificationXref12274
cellular location: GO_0005759
comment: Reactome DB_ID: 379754

Homologues of ELOVL2
type: Protein
data source: Provenance1
member physical entity: Elongation of very long chain fatty acids protein 2
xref: UnificationXref4016
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587929

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI_29157
data source: Provenance1
xref: UnificationXref12276
xref: UnificationXref12277
cellular location: GO_0005759
comment: Reactome DB_ID: 379744

Elongation of very long chain fatty acids protein 2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252837
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0252837
xref: UnificationXref4014
feature: FragmentFeature864
cellular location: GO_0005789
comment: Reactome DB_ID: 5587927
display name: ELOVL2

tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI_29168
data source: Provenance1
xref: UnificationXref12282
xref: UnificationXref12283
cellular location: GO_0005759
comment: Reactome DB_ID: 379740

Elongation of very long chain fatty acids protein 2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216761
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0216761
xref: UnificationXref4015
feature: FragmentFeature865
cellular location: GO_0005789
comment: Reactome DB_ID: 5587928
display name: ELOVL2

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI_29166
data source: Provenance1
xref: UnificationXref12284
xref: UnificationXref12285
cellular location: GO_0005759
comment: Reactome DB_ID: 379753

tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI_29176
data source: Provenance1
xref: UnificationXref12290
xref: UnificationXref12289
cellular location: GO_0005759
comment: Reactome DB_ID: 379770

ACSL
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3988
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5581666

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191105
data source: Provenance1
name: acyl-CoA synthetase long-chain family member 5
name: long-chain acyl-CoA synthetase 5
name: DDB0191105
name: ACSL5
xref: UnificationXref3998
feature: FragmentFeature860
cellular location: GO_0005789
comment: Reactome DB_ID: 5583110
display name: ACS5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231574
data source: Provenance1
name: Long-chain-fatty-acid--CoA ligase 4
name: DDB0231574
xref: UnificationXref3987
feature: FragmentFeature859
cellular location: GO_0005789
comment: Reactome DB_ID: 5581665
display name: ACSL4

http://identifiers.org/pubmed/2575455
type: PublicationXref
id: 2575455
author: Nagatsu, T
db: Pubmed
title: The human tyrosine hydroxylase gene
source: Cell Mol Neurobiol 9:313-21
year: 1989

tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI_29167
data source: Provenance1
xref: UnificationXref12266
xref: UnificationXref12267
cellular location: GO_0005759
comment: Reactome DB_ID: 379714

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI_29152
data source: Provenance1
xref: UnificationXref12268
xref: UnificationXref12269
cellular location: GO_0005759
comment: Reactome DB_ID: 379713

tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI_29186
data source: Provenance1
xref: UnificationXref12257
xref: UnificationXref12258
cellular location: GO_0005759
comment: Reactome DB_ID: 379715

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI_29158
data source: Provenance1
xref: UnificationXref12259
xref: UnificationXref12260
cellular location: GO_0005759
comment: Reactome DB_ID: 379698

tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI_29172
data source: Provenance1
xref: UnificationXref12250
xref: UnificationXref12249
cellular location: GO_0005759
comment: Reactome DB_ID: 379699

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: ChEBI:29265 Asn-tRNA(Asn)
data source: Provenance1
xref: UnificationXref12251
xref: UnificationXref12252
cellular location: GO_0005759
comment: Reactome DB_ID: 379718

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI_18366
data source: Provenance1
xref: UnificationXref12242
xref: UnificationXref12241
cellular location: GO_0005759
comment: Reactome DB_ID: 379708

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref12247
xref: UnificationXref12248
cellular location: GO_0005759
comment: Reactome DB_ID: 379703
display name: L-Asn

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252810
data source: Provenance1
name: Elongation of very long chain fatty acids protein 7
name: DDB0252810
xref: UnificationXref4047
feature: FragmentFeature871
cellular location: GO_0005789
comment: Reactome DB_ID: 5587944
display name: ELOVL7

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI_17732
data source: Provenance1
xref: UnificationXref12234
xref: UnificationXref12235
cellular location: GO_0005759
comment: Reactome DB_ID: 379730

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252835
data source: Provenance1
name: DDB0252835
name: Elongation of very long chain fatty acids protein 7
xref: UnificationXref4049
feature: FragmentFeature872
cellular location: GO_0005789
comment: Reactome DB_ID: 5587948
display name: ELOVL7

tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI_29171
data source: Provenance1
xref: UnificationXref12240
xref: UnificationXref12239
cellular location: GO_0005759
comment: Reactome DB_ID: 379727

Homologues of ELOVL7
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4056
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587959

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0203216
data source: Provenance1
name: Elongation of very long chain fatty acids protein 7
name: DDB0203216
xref: UnificationXref4045
feature: FragmentFeature870
cellular location: GO_0005789
comment: Reactome DB_ID: 5587940
display name: ELOVL7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252837
data source: Provenance1
name: Elongation of very long chain fatty acids protein 5
name: DDB0252837
xref: UnificationXref4033
feature: FragmentFeature868
cellular location: GO_0005789
comment: Reactome DB_ID: 5587919
display name: ELOVL5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216761
data source: Provenance1
name: Elongation of very long chain fatty acids protein 5
name: DDB0216761
xref: UnificationXref4034
feature: FragmentFeature869
cellular location: GO_0005789
comment: Reactome DB_ID: 5587923
display name: ELOVL5

Homologues of ELOVL5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4035
cellular location: GO_0005789
comment: Reactome DB_ID: 5587924
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216761
data source: Provenance1
name: Elongation of very long chain fatty acids protein 4
name: DDB0216761
xref: UnificationXref4026
feature: FragmentFeature867
cellular location: GO_0005789
comment: Reactome DB_ID: 5587967
display name: ELOVL4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252837
data source: Provenance1
name: Elongation of very long chain fatty acids protein 4
name: DDB0252837
xref: UnificationXref4025
feature: FragmentFeature866
cellular location: GO_0005789
comment: Reactome DB_ID: 5587966
display name: ELOVL4

Homologues of ELOVL4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4027
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587968

tRNA(Val)
type: SmallMolecule
entity reference: CHEBI_29183
data source: Provenance1
xref: UnificationXref12221
xref: UnificationXref12222
cellular location: GO_0005829
comment: Reactome DB_ID: 379793

Val-tRNA(Val)
type: SmallMolecule
entity reference: CHEBI_29164
data source: Provenance1
xref: UnificationXref12225
xref: UnificationXref12224
cellular location: GO_0005829
comment: Reactome DB_ID: 379790

tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI_17732
data source: Provenance1
xref: UnificationXref12233
xref: UnificationXref12232
cellular location: GO_0005759
comment: Reactome DB_ID: 379729

tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI_29181
data source: Provenance1
xref: UnificationXref12199
xref: UnificationXref12200
cellular location: GO_0005829
comment: Reactome DB_ID: 379763

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI_29159
data source: Provenance1
xref: UnificationXref12202
xref: UnificationXref12203
cellular location: GO_0005829
comment: Reactome DB_ID: 379765

tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI_29182
data source: Provenance1
xref: UnificationXref12211
xref: UnificationXref12210
cellular location: GO_0005829
comment: Reactome DB_ID: 379743

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI_29161
data source: Provenance1
xref: UnificationXref12214
xref: UnificationXref12213
cellular location: GO_0005829
comment: Reactome DB_ID: 379785

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0218222
data source: Provenance1
name: ATP:glycerol 3-phosphotransferase
name: DDB0218222
name: Glycerokinase
name: Glycerol kinase
xref: UnificationXref4086
feature: FragmentFeature879
cellular location: GO_0005829
comment: Reactome DB_ID: 5581692
display name: GK

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI_29162
data source: Provenance1
xref: UnificationXref12180
xref: UnificationXref12181
cellular location: GO_0005829
comment: Reactome DB_ID: 379738

tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI_29180
data source: Provenance1
xref: UnificationXref12189
xref: UnificationXref12188
cellular location: GO_0005829
comment: Reactome DB_ID: 379749

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI_29163
data source: Provenance1
xref: UnificationXref12192
xref: UnificationXref12191
cellular location: GO_0005829
comment: Reactome DB_ID: 379783

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238277
data source: Provenance1
name: DDB0238277
name: Estradiol 17-beta-dehydrogenase 12
xref: UnificationXref4063
feature: FragmentFeature877
cellular location: GO_0005789
comment: Reactome DB_ID: 5587962
display name: HSD17B12

TECR-like proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4075
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587975

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237530
data source: Provenance1
name: Trans-2,3-enoyl-CoA reductase
name: DDB0237530
xref: UnificationXref4074
feature: FragmentFeature878
cellular location: GO_0005789
comment: Reactome DB_ID: 5587974
display name: TECR

Glycerol kinase
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4087
cellular location: GO_0005829
comment: Reactome DB_ID: 5581693
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214890
data source: Provenance1
name: DDB0214890
name: Elongation of very long chain fatty acids protein 7
xref: UnificationXref4053
feature: FragmentFeature875
cellular location: GO_0005789
comment: Reactome DB_ID: 5587954
display name: ELOVL7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216761
data source: Provenance1
name: Elongation of very long chain fatty acids protein 7
name: DDB0216761
xref: UnificationXref4051
feature: FragmentFeature874
cellular location: GO_0005789
comment: Reactome DB_ID: 5587950
display name: ELOVL7

HSD17B12-like proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4064
cellular location: GO_0005789
comment: Reactome DB_ID: 5587963
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252836
data source: Provenance1
name: DDB0252836
name: Elongation of very long chain fatty acids protein 7
xref: UnificationXref4055
feature: FragmentFeature876
cellular location: GO_0005789
comment: Reactome DB_ID: 5587958
display name: ELOVL7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252837
data source: Provenance1
name: DDB0252837
name: Elongation of very long chain fatty acids protein 7
xref: UnificationXref4050
feature: FragmentFeature873
cellular location: GO_0005789
comment: Reactome DB_ID: 5587949
display name: ELOVL7

http://identifiers.org/pubmed/12807873
type: PublicationXref
id: 12807873
author: Kömüves, LG
author: Ng, CK
author: Topper, JN
author: Wasserman, SM
author: Yang, RB
author: Gerritsen, ME
db: Pubmed
title: A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling
source: J Biol Chem 278:33232-8
year: 2003

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

SequenceSite4400
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4401
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite4402
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/22090471
type: PublicationXref
id: 22090471
author: Jan, Lily Y
author: Huang, Fen
author: Wong, Xiuming
db: Pubmed
title: International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels
source: Pharmacol. Rev. 64:1-15
year: 2012

http://identifiers.org/pubmed/18481987
type: PublicationXref
id: 18481987
author: Sandler, H
author: Stoecklin, G
db: Pubmed
title: Control of mRNA decay by phosphorylation of tristetraprolin
source: Biochem Soc Trans 36:491-6
year: 2008

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

http://identifiers.org/pubmed/19244110
type: PublicationXref
id: 19244110
author: Vikis, HG
author: You, M
author: Lu, Y
author: Liu, Y
author: James, MA
db: Pubmed
title: RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
source: Cancer Res 69:2108-16
year: 2009

SequenceSite4412
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12807890
type: PublicationXref
id: 12807890
author: Walker, JE
author: Dionisi-Vici, C
author: Dolce, V
author: Palmieri, F
author: Fiermonte, G
author: David, L
author: Santorelli, FM
db: Pubmed
title: The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
source: J Biol Chem 278:32778-83
year: 2003

SequenceSite4413
type: SequenceSite
position status: EQUAL
sequence position: 972

SequenceSite4410
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4411
type: SequenceSite
position status: EQUAL
sequence position: 820

SequenceSite4406
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4405
type: SequenceSite
position status: EQUAL
sequence position: 92

SequenceSite4404
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4403
type: SequenceSite
position status: EQUAL
sequence position: 119

SequenceSite4409
type: SequenceSite
position status: EQUAL
sequence position: 142

SequenceSite4408
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4407
type: SequenceSite
position status: EQUAL
sequence position: 95

http://identifiers.org/pubmed/12807887
type: PublicationXref
id: 12807887
author: Morgan, A
author: Bernard, SE
author: Shuttleworth, CA
author: Humphries, J
author: Lomas, A
author: Bax, DV
author: Kielty, CM
author: Humphries, MJ
db: Pubmed
title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
source: J Biol Chem 278:34605-16
year: 2003

SequenceSite4420
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4421
type: SequenceSite
position status: EQUAL
sequence position: 2136

SequenceSite4422
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4423
type: SequenceSite
position status: EQUAL
sequence position: 125

SequenceSite4424
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4415
type: SequenceSite
position status: EQUAL
sequence position: 357

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

SequenceSite4414
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4417
type: SequenceSite
position status: EQUAL
sequence position: 941

SequenceSite4416
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4419
type: SequenceSite
position status: EQUAL
sequence position: 2335

SequenceSite4418
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/17380317
type: PublicationXref
id: 17380317
author: Hussain, K
author: Richardson, CC
author: Christie, MR
author: Jones, PM
author: Löbner, K
author: Clark, A
author: Persaud, S
author: Boehm, A
db: Pubmed
title: Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development
source: Diabetologia 50:1000-5
year: 2007

http://identifiers.org/pubmed/9799232
type: PublicationXref
id: 9799232
author: Wagner, H
author: Mischak, H
author: Sparwasser, T
author: Lipford, GB
author: Schmid, R
author: Heeg, K
author: Miethke, T
author: Hacker, H
author: Liptay, S
db: Pubmed
title: CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
source: EMBO J 17:6230-40
year: 1998

http://identifiers.org/pubmed/9799231
type: PublicationXref
id: 9799231
author: Guillemot, JC
author: Chavrier, P
author: Montcourrier, P
author: Massol, P
db: Pubmed
title: Fc receptor-mediated phagocytosis requires CDC42 and Rac1
source: EMBO J 17:6219-29
year: 1998

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1481
evidence: Evidence2393
xref: UnificationXref15055
xref: UnificationXref15056
pathway order: PathwayStep2349
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

IGF1R signaling cascade
type: Pathway
data source: Provenance1
pathway component: REACT 206330.2
pathway component: REACT 227637.2
evidence: Evidence2276
xref: UnificationXref14457
xref: UnificationXref14458
pathway order: PathwayStep2237
pathway order: PathwayStep2236
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/12032886
type: PublicationXref
id: 12032886
author: Zhou, B
author: Wang, K
author: Gitschier, J
author: Zemansky, J
author: Kuo, YM
db: Pubmed
title: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
source: Am J Hum Genet 71:66-73
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230083
data source: Provenance1
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: DDB0230083
name: amidophosphoribosyltransferase
xref: UnificationXref6501
feature: FragmentFeature1184
cellular location: GO_0005829
comment: Reactome DB_ID: 5580914
display name: PPAT

UCP
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6465
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583201

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233499
data source: Provenance1
name: Mitochondrial brown fat uncoupling protein 1
name: DDB0233499
name: Thermogenin
xref: UnificationXref6462
feature: FragmentFeature1181
cellular location: GO_0005743
comment: Reactome DB_ID: 5583198
display name: UCP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233499
data source: Provenance1
name: DDB0233499
name: Mitochondrial uncoupling protein 2
xref: UnificationXref6463
feature: FragmentFeature1182
cellular location: GO_0005743
comment: Reactome DB_ID: 5583199
display name: UCP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233499
data source: Provenance1
name: UCP3_HUMAN
name: DDB0233499
name: Mitochondrial uncoupling protein 3
xref: UnificationXref6464
feature: FragmentFeature1183
cellular location: GO_0005743
comment: Reactome DB_ID: 5583200
display name: UCP3

DDB0252839
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252839
data source: Provenance1
xref: UnificationXref6426
cellular location: GO_0005759
comment: Reactome DB_ID: 5588152

DDB0267017
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267017
data source: Provenance1
xref: UnificationXref6448
cellular location: GO_0005759
comment: Reactome DB_ID: 5583286

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267018
data source: Provenance1
name: Electron Transfer Flavoprotein beta subunit
name: DDB0267018
name: ETF-beta
xref: UnificationXref6450
feature: FragmentFeature1179
cellular location: GO_0005759
comment: Reactome DB_ID: 5583290
display name: ETFB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0267019
data source: Provenance1
name: DDB0267019
xref: UnificationXref6456
feature: FragmentFeature1180
cellular location: GO_0005759
comment: Reactome DB_ID: 5583298
display name: ETFDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305158
data source: Provenance1
name: DDB0305158
name: D-2-hydroxyglutarate dehydrogenase
xref: UnificationXref6409
feature: FragmentFeature1178
cellular location: GO_0005759
comment: Reactome DB_ID: 5588158
display name: D2HGDH

SequenceSite4469
type: SequenceSite
position status: EQUAL
sequence position: 391

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

SequenceSite4470
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4471
type: SequenceSite
position status: EQUAL
sequence position: 257

SequenceSite4476
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4477
type: SequenceSite
position status: EQUAL
sequence position: 815

SequenceSite4478
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4479
type: SequenceSite
position status: EQUAL
sequence position: 825

SequenceSite4472
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4473
type: SequenceSite
position status: EQUAL
sequence position: 378

http://identifiers.org/pubmed/16682955
type: PublicationXref
id: 16682955
author: Hays, S
author: Westbrook, L
author: Qu, Z
author: Kern, FG
author: Thottassery, JV
author: Rentz, SS
author: Manuvakhova, M
db: Pubmed
title: Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
source: Oncogene 25:6003-14
year: 2006

SequenceSite4474
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4475
type: SequenceSite
position status: EQUAL
sequence position: 353

SequenceSite4481
type: SequenceSite
position status: EQUAL
sequence position: 1150

SequenceSite4482
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4480
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4489
type: SequenceSite
position status: EQUAL
sequence position: 344

SequenceSite4487
type: SequenceSite
position status: EQUAL
sequence position: 372

SequenceSite4488
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4485
type: SequenceSite
position status: EQUAL
sequence position: 305

SequenceSite4486
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4483
type: SequenceSite
position status: EQUAL
sequence position: 272

SequenceSite4484
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231830
type: ProteinReference
xref: UnificationXref13082
organism: http://identifiers.org/taxonomy/44689

SequenceSite4490
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4491
type: SequenceSite
position status: EQUAL
sequence position: 1270

SequenceSite4492
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4493
type: SequenceSite
position status: EQUAL
sequence position: 633

SequenceSite4494
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4495
type: SequenceSite
position status: EQUAL
sequence position: 305

SequenceSite4496
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4497
type: SequenceSite
position status: EQUAL
sequence position: 589

SequenceSite4498
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4499
type: SequenceSite
position status: EQUAL
sequence position: 589

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

UnificationXref12099
type: UnificationXref
id: REACT_15566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15566.1

UnificationXref12097
type: UnificationXref
id: CHEBI:29166
db: ChEBI

UnificationXref12098
type: UnificationXref
id: 379772
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379772

UnificationXref12095
type: UnificationXref
id: 379748
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379748

UnificationXref12096
type: UnificationXref
id: REACT_16123
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16123.1

http://identifiers.org/pubmed/15591024
type: PublicationXref
id: 15591024
author: Takano, K
author: Yoshida, M
author: Asai, M
author: Oiso, Y
author: Itoi, K
author: Yamamori, E
author: Iwasaki, Y
db: Pubmed
title: Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
source: J Mol Endocrinol 33:639-49
year: 2004

http://identifiers.org/pubmed/11879202
type: PublicationXref
id: 11879202
author: Whitsett, J
author: Vásquez-Vivar, J
author: Joseph, J
author: Martasek, P
author: Kalyanaraman, B
db: Pubmed
title: The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
source: Biochem J 362:733-9
year: 2002

http://identifiers.org/pubmed/8163536
type: PublicationXref
id: 8163536
author: Sidorenko, SP
author: Chandran, KA
author: Clark, EA
author: Disteche, CM
author: Edelhoff, S
author: Law, CL
author: Weiss, A
author: Chan, AC
author: Draves, KE
db: Pubmed
title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex
source: J Biol Chem 269:12310-9
year: 1994

Stoichiometry2971
type: Stoichiometry
physical entity: Protein2559
stoichiometric coefficient: 1.0

Stoichiometry2970
type: Stoichiometry
physical entity: Protein453
stoichiometric coefficient: 1.0

Stoichiometry2973
type: Stoichiometry
physical entity: PhysicalEntity211
stoichiometric coefficient: 1.0

Stoichiometry2972
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry2975
type: Stoichiometry
physical entity: Complex60
stoichiometric coefficient: 1.0

Stoichiometry2974
type: Stoichiometry
physical entity: Complex1074
stoichiometric coefficient: 1.0

Stoichiometry2977
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry2976
type: Stoichiometry
physical entity: PhysicalEntity9
stoichiometric coefficient: 2.0

SequenceSite4429
type: SequenceSite
position status: EQUAL
sequence position: 1304

SequenceSite4425
type: SequenceSite
position status: EQUAL
sequence position: 1217

SequenceSite4426
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4427
type: SequenceSite
position status: EQUAL
sequence position: 86

SequenceSite4428
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4433
type: SequenceSite
position status: EQUAL
sequence position: 895

http://identifiers.org/pubmed/15270074
type: PublicationXref
id: 15270074
author: Kingston, Robert E
author: Chen, Will C
author: Trinklein, Nathan D
author: Myers, Richard M
db: Pubmed
title: Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
source: Cell Stress Chaperones 9:21-8
year: 2004

SequenceSite4432
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11735028
type: PublicationXref
id: 11735028
author: Minoshima, S
author: Hiratsuka, M
author: Inui, K
author: Kure, S
author: Narisawa, K
author: Yang, X
author: Aoki, Y
author: Ohki, M
author: Kudoh, J
author: Shintani, A
author: Christensen, E
author: Kubota, M
author: Li, X
author: Taheri, S
author: Suzuki, Y
author: Kawasaki, K
author: Sakamoto, O
author: Shimizu, N
author: Asakawa, S
author: Shibuya, K
author: Ohira, M
author: Matsubara, Y
db: Pubmed
title: Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiency
source: Hum. Genet. 109:526-34
year: 2001

SequenceSite4435
type: SequenceSite
position status: EQUAL
sequence position: 110

SequenceSite4434
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4431
type: SequenceSite
position status: EQUAL
sequence position: 424

SequenceSite4430
type: SequenceSite
position status: EQUAL
sequence position: 2

Stoichiometry2978
type: Stoichiometry
physical entity: Complex60
stoichiometric coefficient: 1.0

Stoichiometry2979
type: Stoichiometry
physical entity: Complex62
stoichiometric coefficient: 1.0

Stoichiometry2984
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry2983
type: Stoichiometry
physical entity: Complex1050
stoichiometric coefficient: 1.0

Stoichiometry2982
type: Stoichiometry
physical entity: Complex1078
stoichiometric coefficient: 1.0

Stoichiometry2981
type: Stoichiometry
physical entity: Protein2561
stoichiometric coefficient: 1.0

Stoichiometry2988
type: Stoichiometry
physical entity: PhysicalEntity21
stoichiometric coefficient: 1.0

Stoichiometry2987
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry2986
type: Stoichiometry
physical entity: Complex1050
stoichiometric coefficient: 1.0

Stoichiometry2985
type: Stoichiometry
physical entity: PhysicalEntity21
stoichiometric coefficient: 1.0

SequenceSite4438
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2980
type: Stoichiometry
physical entity: SmallMolecule11
stoichiometric coefficient: 1.0

SequenceSite4439
type: SequenceSite
position status: EQUAL
sequence position: 501

SequenceSite4436
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4437
type: SequenceSite
position status: EQUAL
sequence position: 793

SequenceSite4446
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4445
type: SequenceSite
position status: EQUAL
sequence position: 255

SequenceSite4444
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4443
type: SequenceSite
position status: EQUAL
sequence position: 225

SequenceSite4442
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4441
type: SequenceSite
position status: EQUAL
sequence position: 464

SequenceSite4440
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry2989
type: Stoichiometry
physical entity: SmallMolecule55
stoichiometric coefficient: 1.0

Stoichiometry2997
type: Stoichiometry
physical entity: Protein2565
stoichiometric coefficient: 1.0

Stoichiometry2996
type: Stoichiometry
physical entity: Protein2564
stoichiometric coefficient: 1.0

Stoichiometry2999
type: Stoichiometry
physical entity: SmallMolecule55
stoichiometric coefficient: 1.0

Stoichiometry2998
type: Stoichiometry
physical entity: Protein2566
stoichiometric coefficient: 1.0

Stoichiometry2993
type: Stoichiometry
physical entity: PhysicalEntity21
stoichiometric coefficient: 1.0

Stoichiometry2992
type: Stoichiometry
physical entity: PhysicalEntity210
stoichiometric coefficient: 1.0

Stoichiometry2995
type: Stoichiometry
physical entity: Protein2563
stoichiometric coefficient: 1.0

Stoichiometry2994
type: Stoichiometry
physical entity: Protein2562
stoichiometric coefficient: 1.0

SequenceSite4447
type: SequenceSite
position status: EQUAL
sequence position: 579

SequenceSite4448
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4449
type: SequenceSite
position status: EQUAL
sequence position: 494

Stoichiometry2991
type: Stoichiometry
physical entity: Complex63
stoichiometric coefficient: 1.0

Stoichiometry2990
type: Stoichiometry
physical entity: Protein2561
stoichiometric coefficient: 1.0

SequenceSite4451
type: SequenceSite
position status: EQUAL
sequence position: 514

SequenceSite4450
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4453
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite4452
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4455
type: SequenceSite
position status: EQUAL
sequence position: 225

SequenceSite4454
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4457
type: SequenceSite
position status: EQUAL
sequence position: 504

SequenceSite4456
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4458
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4459
type: SequenceSite
position status: EQUAL
sequence position: 563

SequenceSite4464
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4463
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4462
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4461
type: SequenceSite
position status: EQUAL
sequence position: 904

SequenceSite4468
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4467
type: SequenceSite
position status: EQUAL
sequence position: 856

SequenceSite4466
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4465
type: SequenceSite
position status: EQUAL
sequence position: 475

SequenceSite4460
type: SequenceSite
position status: EQUAL
sequence position: 1

GRB2 events in ERBB2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 202664.2
evidence: Evidence2212
xref: UnificationXref14051
xref: UnificationXref14050
pathway order: PathwayStep40
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12154
type: UnificationXref
id: REACT_229687
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229687.1

UnificationXref12155
type: UnificationXref
id: CHEBI:29184
db: ChEBI

Stoichiometry2949
type: Stoichiometry
physical entity: SmallMolecule11
stoichiometric coefficient: 1.0

UnificationXref12156
type: UnificationXref
id: 379767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379767

UnificationXref12157
type: UnificationXref
id: REACT_17850
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17850.1

UnificationXref12150
type: UnificationXref
id: CHEBI:16635
db: ChEBI

Stoichiometry2946
type: Stoichiometry
physical entity: Complex1062
stoichiometric coefficient: 1.0

UnificationXref12151
type: UnificationXref
id: 379794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379794

Stoichiometry2945
type: Stoichiometry
physical entity: Protein2548
stoichiometric coefficient: 1.0

UnificationXref12152
type: UnificationXref
id: REACT_18004
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18004.1

Stoichiometry2948
type: Stoichiometry
physical entity: Protein2550
stoichiometric coefficient: 1.0

UnificationXref12153
type: UnificationXref
id: 5585925
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585925

Stoichiometry2947
type: Stoichiometry
physical entity: PhysicalEntity203
stoichiometric coefficient: 1.0

UnificationXref12158
type: UnificationXref
id: CHEBI:29153
db: ChEBI

UnificationXref12159
type: UnificationXref
id: 379792
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379792

Stoichiometry2941
type: Stoichiometry
physical entity: Protein2548
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/17555535
type: PublicationXref
id: 17555535
author: Sherwood, MW
author: Burgoyne, RD
author: Dolman, NJ
author: Haynes, LP
db: Pubmed
title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta
source: Traffic 8:1080-92
year: 2007

Stoichiometry2942
type: Stoichiometry
physical entity: SmallMolecule4
stoichiometric coefficient: 1.0

UnificationXref12160
type: UnificationXref
id: REACT_15573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15573.1

Stoichiometry2943
type: Stoichiometry
physical entity: Protein2549
stoichiometric coefficient: 1.0

Stoichiometry2944
type: Stoichiometry
physical entity: Complex1062
stoichiometric coefficient: 1.0

Stoichiometry2940
type: Stoichiometry
physical entity: Complex1058
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191395
data source: Provenance1
name: DDB0191395
name: alkaline ceramidase 3
xref: UnificationXref5876
feature: FragmentFeature1105
cellular location: GO_0005789
comment: Reactome DB_ID: 5587035
display name: ACER3

UnificationXref12167
type: UnificationXref
id: REACT_227098
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227098.2

Homologues of SPHK1
type: Protein
data source: Provenance1
member physical entity: DDB0185181
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5890
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586601

UnificationXref12168
type: UnificationXref
id: CHEBI:29177
db: ChEBI

Homologues of ACER3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5877
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587036

UnificationXref12165
type: UnificationXref
id: 5585829
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585829

Stoichiometry2939
type: Stoichiometry
physical entity: Protein2534
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232053
data source: Provenance1
name: DDB0232053
name: alkaline ceramidase 3
xref: UnificationXref5874
feature: FragmentFeature1104
cellular location: GO_0005789
comment: Reactome DB_ID: 5587031
display name: ACER3

UnificationXref12166
type: UnificationXref
id: 5585831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585831

Stoichiometry2938
type: Stoichiometry
physical entity: Protein2539
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232041
data source: Provenance1
name: PXLP-SPTLC2
name: DDB0232041
name: serine palmitoyltransferase 2
xref: UnificationXref5860
feature: FragmentFeature1102
feature: ModificationFeature185
cellular location: GO_0005789
comment: Reactome DB_ID: 5586993
display name: SPTLC2

UnificationXref12163
type: UnificationXref
id: DDB0231328
db: UniProt

Stoichiometry2937
type: Stoichiometry
physical entity: Complex1050
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232041
data source: Provenance1
name: PXLP-SPTLC3
name: DDB0232041
name: serine palmitoyltransferase 3
xref: UnificationXref5862
feature: FragmentFeature1103
feature: ModificationFeature186
cellular location: GO_0005789
comment: Reactome DB_ID: 5586996
display name: SPTLC3

UnificationXref12164
type: UnificationXref
id: 5585824
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585824

Stoichiometry2936
type: Stoichiometry
physical entity: transfer RNA
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232045
data source: Provenance1
name: DDB0232045
name: sphingolipid delta(4)-desaturase 1
name: degenerative spermatocyte homolog 1
xref: UnificationXref5846
feature: FragmentFeature1100
cellular location: GO_0005789
comment: Reactome DB_ID: 5587023
display name: DEGS1

UnificationXref12161
type: UnificationXref
id: DDB0231327
db: UniProt

Stoichiometry2935
type: Stoichiometry
physical entity: Complex1049
stoichiometric coefficient: 1.0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232040
data source: Provenance1
name: serine palmitoyltransferase 1
name: DDB0232040
xref: UnificationXref5858
feature: FragmentFeature1101
cellular location: GO_0005789
comment: Reactome DB_ID: 5586988
display name: SPTLC1

UnificationXref12162
type: UnificationXref
id: 5585828
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585828

Stoichiometry2934
type: Stoichiometry
physical entity: Complex1059
stoichiometric coefficient: 1.0

DDB0185181
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185181
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sphingosine kinase 1
xref: UnificationXref5887
feature: FragmentFeature1106
cellular location: GO_0005829
comment: Reactome DB_ID: 5586596
display name: SPHK1

UnificationXref12169
type: UnificationXref
id: 379768
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379768

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220131
data source: Provenance1
name: Sphingosine kinase 1
name: DDB0220131
xref: UnificationXref5889
feature: FragmentFeature1107
cellular location: GO_0005829
comment: Reactome DB_ID: 5586600
display name: SPHK1

UnificationXref12171
type: UnificationXref
id: CHEBI:29154
db: ChEBI

Stoichiometry2932
type: Stoichiometry
physical entity: Protein504
stoichiometric coefficient: 1.0

UnificationXref12170
type: UnificationXref
id: REACT_15779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15779.1

Stoichiometry2933
type: Stoichiometry
physical entity: Complex1055
stoichiometric coefficient: 1.0

Stoichiometry2930
type: Stoichiometry
physical entity: Protein454
stoichiometric coefficient: 1.0

Stoichiometry2931
type: Stoichiometry
physical entity: PhysicalEntity201
stoichiometric coefficient: 1.0

NGF signalling via TRKA from the plasma membrane
type: Pathway
data source: Provenance1
pathway component: REACT 221271.2
pathway component: Signalling to ERK5
pathway component: REACT 219319.2
pathway component: REACT 211700.2
pathway component: REACT 243835.1
evidence: Evidence2200
xref: UnificationXref14011
xref: UnificationXref14012
pathway order: PathwayStep2161
pathway order: PathwayStep2160
pathway order: PathwayStep2157
pathway order: PathwayStep2155
pathway order: PathwayStep2154
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Stoichiometry2968
type: Stoichiometry
physical entity: Complex63
stoichiometric coefficient: 1.0

Stoichiometry2967
type: Stoichiometry
physical entity: Protein455
stoichiometric coefficient: 1.0

UnificationXref12130
type: UnificationXref
id: REACT_245873
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245873.1

UnificationXref12131
type: UnificationXref
id: CHEBI:29169
db: ChEBI

Stoichiometry2969
type: Stoichiometry
physical entity: Complex67
stoichiometric coefficient: 1.0

UnificationXref12132
type: UnificationXref
id: 379771
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379771

UnificationXref12133
type: UnificationXref
id: REACT_15877
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15877.1

UnificationXref12134
type: UnificationXref
id: CHEBI:16624
db: ChEBI

UnificationXref12135
type: UnificationXref
id: 379757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379757

UnificationXref12136
type: UnificationXref
id: REACT_17915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17915.1

UnificationXref12137
type: UnificationXref
id: 5585898
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585898

dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI_16214
data source: Provenance1
xref: UnificationXref13071
xref: UnificationXref13072
cellular location: GO_0005789
comment: Reactome DB_ID: 162872

UnificationXref12138
type: UnificationXref
id: REACT_231374
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231374.1

mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI_53058
data source: Provenance1
xref: UnificationXref13074
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5582976

UnificationXref12139
type: UnificationXref
id: CHEBI:29185
db: ChEBI

mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI_53059
data source: Provenance1
xref: UnificationXref13081
xref: UnificationXref13080
cellular location: GO_0005789
comment: Reactome DB_ID: 162684

(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
data source: Provenance1
xref: UnificationXref13087
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5582958
display name: acyl-GPI

(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI_77364
data source: Provenance1
xref: UnificationXref13096
xref: UnificationXref13097
cellular location: GO_0005789
comment: Reactome DB_ID: 162799

E,E-farnesyl diphosphate
type: SmallMolecule
entity reference: CHEBI_17407
data source: Provenance1
name: trans, trans-farnesyl pyrophosphate
name: E,E-farnesyl pyrophosphate
xref: UnificationXref13107
xref: UnificationXref13108
cellular location: GO_0005829
comment: Reactome DB_ID: 4419987
display name: E,E-FPP

polypreneol pyrophosphate
type: SmallMolecule
entity reference: CHEBI_37531
data source: Provenance1
name: polyprenol diphosphate
name: ditrans, polycis-polyprenol pyrophosphate
xref: UnificationXref13110
xref: UnificationXref13111
cellular location: GO_0071458
comment: Reactome DB_ID: 4419982
display name: pPPP

mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI_53056
data source: Provenance1
xref: UnificationXref13059
xref: UnificationXref13058
cellular location: GO_0005789
comment: Reactome DB_ID: 162793

glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI_52572
data source: Provenance1
xref: UnificationXref13052
xref: UnificationXref13051
cellular location: GO_0005789
comment: Reactome DB_ID: 162856
display name: GlcN-acyl-PI

1,2-Diacylglyceroll
type: SmallMolecule
entity reference: CHEBI_17815
data source: Provenance1
xref: UnificationXref13063
xref: UnificationXref13064
cellular location: GO_0005789
comment: Reactome DB_ID: 162777
display name: DAG

phosphatidylethanolamine
type: SmallMolecule
entity reference: CHEBI_16038
data source: Provenance1
xref: UnificationXref13061
xref: UnificationXref13062
cellular location: GO_0005789
comment: Reactome DB_ID: 162803
display name: PE

Stoichiometry2960
type: Stoichiometry
physical entity: PhysicalEntity206
stoichiometric coefficient: 1.0

Stoichiometry2961
type: Stoichiometry
physical entity: PhysicalEntity207
stoichiometric coefficient: 1.0

Stoichiometry2962
type: Stoichiometry
physical entity: Protein2556
stoichiometric coefficient: 1.0

Stoichiometry2963
type: Stoichiometry
physical entity: PhysicalEntity208
stoichiometric coefficient: 1.0

Stoichiometry2964
type: Stoichiometry
physical entity: Protein2557
stoichiometric coefficient: 1.0

Stoichiometry2965
type: Stoichiometry
physical entity: Protein2558
stoichiometric coefficient: 1.0

Stoichiometry2966
type: Stoichiometry
physical entity: PhysicalEntity209
stoichiometric coefficient: 1.0

UnificationXref12141
type: UnificationXref
id: REACT_15975
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15975.1

Stoichiometry2959
type: Stoichiometry
physical entity: Protein2555
stoichiometric coefficient: 1.0

UnificationXref12142
type: UnificationXref
id: CHEBI:16047
db: ChEBI

Stoichiometry2958
type: Stoichiometry
physical entity: Protein2554
stoichiometric coefficient: 1.0

Stoichiometry2957
type: Stoichiometry
physical entity: PhysicalEntity205
stoichiometric coefficient: 1.0

UnificationXref12140
type: UnificationXref
id: 379776
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379776

Stoichiometry2956
type: Stoichiometry
physical entity: Protein2553
stoichiometric coefficient: 1.0

UnificationXref12145
type: UnificationXref
id: 5585940
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585940

UnificationXref12146
type: UnificationXref
id: REACT_230065
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230065.1

Extension of Telomeres
type: Pathway
data source: Provenance1
pathway component: REACT 208789.2
pathway component: Telomere C-strand (Lagging Strand) Synthesis
evidence: Evidence1461
xref: UnificationXref9552
xref: UnificationXref9553
pathway order: PathwayStep1428
pathway order: PathwayStep1436
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12143
type: UnificationXref
id: 379736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379736

UnificationXref12144
type: UnificationXref
id: REACT_15620
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15620.1

UnificationXref12149
type: UnificationXref
id: REACT_15914
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15914.1

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI_16214
data source: Provenance1
name: Dolichol phosphate
xref: UnificationXref13007
xref: UnificationXref13006
cellular location: GO_0071458
comment: Reactome DB_ID: 449299
display name: DOLP

dolichyl phosphate D-mannose
type: SmallMolecule
entity reference: dolichyl D-mannosyl phosphate [ChEBI:15809]
data source: Provenance1
name: dolichyl D-mannosyl phosphate
xref: UnificationXref13009
xref: UnificationXref13010
cellular location: GO_0071458
comment: Reactome DB_ID: 162681
display name: DOLPman

UnificationXref12147
type: UnificationXref
id: CHEBI:29173
db: ChEBI

UnificationXref12148
type: UnificationXref
id: 379742
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379742

glucosaminyl-PI
type: SmallMolecule
entity reference: CHEBI_24275
data source: Provenance1
xref: UnificationXref13043
xref: UnificationXref13042
cellular location: GO_0005789
comment: Reactome DB_ID: 162839
display name: GlcN-PI

Fatty acyl CoA
type: SmallMolecule
entity reference: CHEBI_37554
data source: Provenance1
xref: UnificationXref13048
xref: UnificationXref13049
cellular location: GO_0005788
comment: Reactome DB_ID: 162768
display name: acyl-CoA

N-acetylglucosaminyl-PI
type: SmallMolecule
entity reference: CHEBI_15935
data source: Provenance1
name: N-acetyl-D-glucosaminylphosphatidylinositol
xref: UnificationXref13026
xref: UnificationXref13027
cellular location: GO_0005789
comment: Reactome DB_ID: 162341
display name: GlcNAc-PI

Acetate
type: SmallMolecule
entity reference: CHEBI_15366
data source: Provenance1
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref13039
xref: UnificationXref13040
cellular location: GO_0005829
comment: Reactome DB_ID: 29416
display name: CH3COO-

Stoichiometry2950
type: Stoichiometry
physical entity: Protein2551
stoichiometric coefficient: 1.0

Stoichiometry2951
type: Stoichiometry
physical entity: Complex1065
stoichiometric coefficient: 1.0

Stoichiometry2954
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 2.0

Stoichiometry2955
type: Stoichiometry
physical entity: SmallMolecule7
stoichiometric coefficient: 2.0

Stoichiometry2952
type: Stoichiometry
physical entity: PhysicalEntity205
stoichiometric coefficient: 1.0

Stoichiometry2953
type: Stoichiometry
physical entity: Protein2552
stoichiometric coefficient: 1.0

Stoichiometry2909
type: Stoichiometry
physical entity: Complex1053
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/1703535
type: PublicationXref
id: 1703535
author: Purdue, PE
author: Danpure, CJ
author: Takada, Y
db: Pubmed
title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
source: J Cell Biol 111:2341-51
year: 1990

UnificationXref12199
type: UnificationXref
id: 379763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379763

Stoichiometry2905
type: Stoichiometry
physical entity: Protein2540
stoichiometric coefficient: 1.0

UnificationXref12198
type: UnificationXref
id: CHEBI:29181
db: ChEBI

Stoichiometry2906
type: Stoichiometry
physical entity: PhysicalEntity9
stoichiometric coefficient: 1.0

Stoichiometry2907
type: Stoichiometry
physical entity: Protein2541
stoichiometric coefficient: 1.0

Stoichiometry2908
type: Stoichiometry
physical entity: Protein2542
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/11863375
type: PublicationXref
id: 11863375
author: Yang, RZ
author: Shuldiner, AR
author: Gong, DW
author: Blaileanu, G
author: Hansen, BC
db: Pubmed
title: cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
source: Genomics 79:445-50
year: 2002

UnificationXref12195
type: UnificationXref
id: 5585936
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585936

Stoichiometry2901
type: Stoichiometry
physical entity: Complex63
stoichiometric coefficient: 1.0

UnificationXref12194
type: UnificationXref
id: 5585935
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585935

Stoichiometry2902
type: Stoichiometry
physical entity: Complex57
stoichiometric coefficient: 1.0

UnificationXref12197
type: UnificationXref
id: REACT_211723
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211723.2

Stoichiometry2903
type: Stoichiometry
physical entity: Complex1050
stoichiometric coefficient: 1.0

UnificationXref12196
type: UnificationXref
id: 5585938
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585938

Stoichiometry2904
type: Stoichiometry
physical entity: Protein2539
stoichiometric coefficient: 1.0

Stoichiometry2900
type: Stoichiometry
physical entity: transfer RNA
stoichiometric coefficient: 1.0

SUMO is conjugated to E1 (UBA2:SAE1)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1375
pathway component: BiochemicalReaction1373
pathway component: BiochemicalReaction1374
evidence: Evidence2086
xref: RelationshipXref1711
xref: UnificationXref13553
xref: UnificationXref13554
pathway order: PathwayStep2046
pathway order: PathwayStep2048
pathway order: PathwayStep2047
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

SequenceSite4398
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4397
type: SequenceSite
position status: EQUAL
sequence position: 126

SequenceSite4396
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4395
type: SequenceSite
position status: EQUAL
sequence position: 86

SequenceSite4399
type: SequenceSite
position status: EQUAL
sequence position: 118

SequenceSite4390
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4394
type: SequenceSite
position status: EQUAL
sequence position: 2

abacavir [ChEBI:421707]
type: SmallMoleculeReference
name: abacavir
name: {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
xref: UnificationXref8428

SequenceSite4393
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite4392
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4391
type: SequenceSite
position status: EQUAL
sequence position: 128

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

UnificationXref12173
type: UnificationXref
id: REACT_17288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17288.1

Stoichiometry2923
type: Stoichiometry
physical entity: Complex1047
stoichiometric coefficient: 1.0

UnificationXref12172
type: UnificationXref
id: 379746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379746

Stoichiometry2924
type: Stoichiometry
physical entity: Complex1048
stoichiometric coefficient: 1.0

UnificationXref12175
type: UnificationXref
id: REACT_253553
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253553.1

Stoichiometry2925
type: Stoichiometry
physical entity: SmallMolecule6
stoichiometric coefficient: 4.0

UnificationXref12174
type: UnificationXref
id: 5585885
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585885

Stoichiometry2926
type: Stoichiometry
physical entity: Protein2547
stoichiometric coefficient: 1.0

UnificationXref12177
type: UnificationXref
id: 379762
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379762

Stoichiometry2927
type: Stoichiometry
physical entity: Complex1047
stoichiometric coefficient: 1.0

UnificationXref12176
type: UnificationXref
id: CHEBI:29179
db: ChEBI

Stoichiometry2928
type: Stoichiometry
physical entity: Complex1048
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/11435118
type: PublicationXref
id: 11435118
author: Timm, DE
author: Harris, RA
author: Dorocke, JA
author: Baker, LJ
db: Pubmed
title: The crystal structure of yeast thiamin pyrophosphokinase
source: Structure 9:539-46
year: 2001

UnificationXref12179
type: UnificationXref
id: CHEBI:29162
db: ChEBI

Stoichiometry2929
type: Stoichiometry
physical entity: SmallMolecule7
stoichiometric coefficient: 4.0

UnificationXref12178
type: UnificationXref
id: REACT_16106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16106.1

Stoichiometry2920
type: Stoichiometry
physical entity: Complex1055
stoichiometric coefficient: 1.0

UnificationXref12180
type: UnificationXref
id: 379738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379738

UnificationXref12181
type: UnificationXref
id: REACT_17419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17419.1

Stoichiometry2922
type: Stoichiometry
physical entity: Protein2534
stoichiometric coefficient: 1.0

UnificationXref12182
type: UnificationXref
id: DDB0231305
db: UniProt

Stoichiometry2921
type: Stoichiometry
physical entity: Complex1054
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/10783391
type: PublicationXref
id: 10783391
author: Gabel, CA
author: Schulte, GK
author: Hoth, LR
author: Chelvanayagam, G
author: Chrunyk, BA
author: Geoghegan, KF
author: Coggan, M
author: Easteal, S
author: Kamath, AV
author: Board, PG
author: Jermiin, LS
author: Pandit, J
author: Rosner, MH
author: Perregaux, DE
author: Danley, DE
author: Griffor, MC
db: Pubmed
title: Identification, characterization, and crystal structure of the Omega class glutathione transferases
source: J Biol Chem 275:24798-806
year: 2000

UnificationXref12186
type: UnificationXref
id: REACT_204097
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204097.2

Stoichiometry2914
type: Stoichiometry
physical entity: Complex1051
stoichiometric coefficient: 1.0

HSF1 activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1192
pathway component: BiochemicalReaction1193
pathway component: BiochemicalReaction1194
pathway component: BiochemicalReaction1195
pathway component: BiochemicalReaction1196
evidence: Evidence1829
xref: RelationshipXref1514
xref: UnificationXref11608
xref: UnificationXref11607
pathway order: PathwayStep1793
pathway order: PathwayStep1792
pathway order: PathwayStep1789
pathway order: PathwayStep1790
pathway order: PathwayStep1791
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12185
type: UnificationXref
id: 5585921
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585921

Stoichiometry2915
type: Stoichiometry
physical entity: PhysicalEntity200
stoichiometric coefficient: 1.0

UnificationXref12184
type: UnificationXref
id: 5585919
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585919

Stoichiometry2912
type: Stoichiometry
physical entity: Complex1052
stoichiometric coefficient: 1.0

UnificationXref12183
type: UnificationXref
id: 5585918
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585918

Stoichiometry2913
type: Stoichiometry
physical entity: Protein2544
stoichiometric coefficient: 1.0

Stoichiometry2918
type: Stoichiometry
physical entity: Protein2545
stoichiometric coefficient: 1.0

UnificationXref12189
type: UnificationXref
id: REACT_15966
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15966.1

Stoichiometry2919
type: Stoichiometry
physical entity: Protein2546
stoichiometric coefficient: 1.0

UnificationXref12188
type: UnificationXref
id: 379749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379749

Stoichiometry2916
type: Stoichiometry
physical entity: Protein454
stoichiometric coefficient: 1.0

UnificationXref12187
type: UnificationXref
id: CHEBI:29180
db: ChEBI

Stoichiometry2917
type: Stoichiometry
physical entity: Protein504
stoichiometric coefficient: 1.0

UnificationXref12192
type: UnificationXref
id: REACT_17415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17415.1

Stoichiometry2911
type: Stoichiometry
physical entity: Protein2543
stoichiometric coefficient: 1.0

UnificationXref12193
type: UnificationXref
id: DDB0231248
db: UniProt

Stoichiometry2910
type: Stoichiometry
physical entity: PhysicalEntity9
stoichiometric coefficient: 1.0

UnificationXref12190
type: UnificationXref
id: CHEBI:29163
db: ChEBI

UnificationXref12191
type: UnificationXref
id: 379783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379783

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231294
data source: Provenance1
name: DDB0231294
name: NAD+-specific ICDH
name: Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) beta
name: Isocitric dehydrogenase
xref: UnificationXref6333
feature: FragmentFeature1165
cellular location: GO_0005759
comment: Reactome DB_ID: 5579472
display name: IDH3B

isocitrate dehydrogenase 3 (NAD+) gamma
type: Protein
entity reference: UniProt:DDB0231294
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0231294
name: Isocitrate dehydrogenase (NAD) subunit gamma, mitochondrial precursor
name: NAD+-specific ICDH
name: Isocitric dehydrogenase
xref: UnificationXref6332
feature: FragmentFeature1164
cellular location: GO_0005759
comment: Reactome DB_ID: 5579473
display name: IDH3G

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231288
data source: Provenance1
name: Isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) alpha
name: NAD+-specific ICDH
name: DDB0231288
name: Isocitric dehydrogenase
xref: UnificationXref6330
feature: FragmentFeature1163
cellular location: GO_0005759
comment: Reactome DB_ID: 5579468
display name: IDH3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230168
data source: Provenance1
name: aconitase 2, mitochondrial
name: DDB0230168
name: Aconitase
name: Aconitate hydratase, mitochondrial precursor
name: Citrate hydro-lyase
xref: UnificationXref6324
feature: FragmentFeature1162
cellular location: GO_0005759
comment: Reactome DB_ID: 5579481
display name: ACO2

DDB0220638
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220638
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Citrate synthase, mitochondrial precursor
name: citrate synthase
xref: UnificationXref6317
feature: FragmentFeature1161
cellular location: GO_0005759
comment: Reactome DB_ID: 5579487
display name: CS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229442
data source: Provenance1
name: Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor
name: ODPA_HUMAN
name: PDHE1-B
name: pyruvate dehydrogenase E1 beta apoprotein
name: DDB0229442
xref: UnificationXref6307
feature: FragmentFeature1160
cellular location: GO_0005759
comment: Reactome DB_ID: 5579737
display name: PDHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230193
data source: Provenance1
name: ODPA_HUMAN
name: DDB0230193
name: pyruvate dehydrogenase E1 alpha apoprotein
name: Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor
name: PDHE1-A type I
xref: UnificationXref6305
feature: FragmentFeature1159
cellular location: GO_0005759
comment: Reactome DB_ID: 5579733
display name: PDHA1

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: L-serine
member physical entity: L-alpha-Alanine
member physical entity: (S)-alpha-Amino-1H-imidazole-4-propionic acid
member physical entity: 2-Amino-3-methylbutyric acid
member physical entity: L-Isoleucine
member physical entity: L-Leucine
member physical entity: 2,6-diaminohexanoic acid
member physical entity: glycine
member physical entity: L-Methionine
member physical entity: L-Phenylalanine
member physical entity: 2-Pyrrolidinecarboxylic acid
member physical entity: L-Threonine
member physical entity: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
member physical entity: L-Glutamine
member physical entity: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
member physical entity: 2-aminosuccinic acid
member physical entity: L-Glutaminic acid
member physical entity: (S)-2-Amino-5-guanidinovaleric acid
member physical entity: L-Asparagine
xref: UnificationXref14608
cellular location: GO_0005788
comment: Reactome DB_ID: 5588649
comment: Converted from EntitySet in Reactome

L-alpha-Alanine
type: SmallMolecule
entity reference: CHEBI_16977
data source: Provenance1
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref14568
xref: UnificationXref14569
cellular location: GO_0005788
comment: Reactome DB_ID: 983018
display name: L-Ala

iron (ferric)
type: SmallMolecule
entity reference: CHEBI_29034
data source: Provenance1
xref: UnificationXref14420
xref: UnificationXref14419
cellular location: GO_0005654
comment: Reactome DB_ID: 2685584
display name: Fe3+

PIP3, PI(3,4)P2
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule583
member physical entity: SmallMolecule53
xref: UnificationXref14479
cellular location: GO_0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5585178

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234117
data source: Provenance1
name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
name: 2-oxoglutarate dehydrogenase E1
name: ODO1_HUMAN
name: DDB0234117
name: Alpha-ketoglutarate dehydrogenase
name: alpha-ketoglutarate dehydrogenase E1 apoenzyme
xref: UnificationXref6352
feature: FragmentFeature1168
cellular location: GO_0005759
comment: Reactome DB_ID: 5579565
display name: OGDH

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

Sphingosine-1-phosphate
type: SmallMolecule
entity reference: CHEBI_37550
data source: Provenance1
name: SPGP
xref: UnificationXref14033
xref: UnificationXref14034
cellular location: GO_0005886
comment: Reactome DB_ID: 5218688
display name: S1P

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231372
data source: Provenance1
name: DDB0231372
name: NAD
name: nicotinamide nucleotide transhydrogenase
xref: UnificationXref6341
feature: FragmentFeature1166
cellular location: GO_0005743
comment: Reactome DB_ID: 5587719
display name: NNT

DDB0230198
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230198
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: alpha-ketoglutarate dehydrogenase E2
name: Dihydrolipoamide succinyltransferase
name: Lipo-DLST
xref: UnificationXref6346
feature: FragmentFeature1167
feature: ModificationFeature196
cellular location: GO_0005759
comment: Reactome DB_ID: 5579572
display name: DLST

Nitric oxide stimulates guanylate cyclase
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction46
pathway component: REACT 227374.2
evidence: Evidence103
xref: UnificationXref767
xref: UnificationXref766
pathway order: PathwayStep90
pathway order: PathwayStep87
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref14579
xref: UnificationXref14578
cellular location: GO_0005788
comment: Reactome DB_ID: 983024
display name: L-Gln

2-aminosuccinic acid
type: SmallMolecule
entity reference: 2-aminosuccinic acid
data source: Provenance1
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref14575
xref: UnificationXref14574
cellular location: GO_0005788
comment: Reactome DB_ID: 983012
display name: L-Asp

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref14577
xref: UnificationXref14576
cellular location: GO_0005788
comment: Reactome DB_ID: 983029
display name: L-Glu

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI_16467
data source: Provenance1
name: L-Arginine
xref: UnificationXref14571
xref: UnificationXref14570
cellular location: GO_0005788
comment: Reactome DB_ID: 983022
display name: L-Arg

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref14573
xref: UnificationXref14572
cellular location: GO_0005788
comment: Reactome DB_ID: 983015
display name: L-Asn

Succinate dehydrogenase (ubiquinone) iron-sulfur protein, mitochondrial
type: Protein
entity reference: UniProt:DDB0231383
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SDHB
name: Succinate Dehydrogenase complex subunit B
name: Iron-sulfur subunit of complex II
name: DDB0231383
xref: UnificationXref6382
feature: FragmentFeature1174
cellular location: GO_0005743
comment: Reactome DB_ID: 5579509
display name: Ip

SDHA
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214886
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Flavoprotein subunit of complex II
name: Succinate Dehydrogenase complex subunit A
name: DDB0214886
name: Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial
xref: UnificationXref6376
feature: FragmentFeature1173
cellular location: GO_0005743
comment: Reactome DB_ID: 5579504
display name: Fp

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231400
data source: Provenance1
name: DDB0231400
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
xref: UnificationXref6388
feature: FragmentFeature1175
cellular location: GO_0005759
comment: Reactome DB_ID: 5579494
display name: FH

Homologues of FH
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6391
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5579497

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191520
data source: Provenance1
name: DDB0191520
name: Succinyl-CoA synthetase, alpha-chain
xref: UnificationXref6361
feature: FragmentFeature1170
cellular location: GO_0005759
comment: Reactome DB_ID: 5579522
display name: SUCLG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231358
data source: Provenance1
name: Succinyl-CoA synthetase, betaG chain
name: DDB0231358
xref: UnificationXref6359
feature: FragmentFeature1169
cellular location: GO_0005759
comment: Reactome DB_ID: 5579828
display name: SUCLG2

Succinate Dehydrogenase complex subunit C
type: Protein
entity reference: UniProt:DDB0231385
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Succinate dehydrogenase complex subunit C
name: CYBL
name: QPS1
name: Succinate-ubiquinone oxidoreductase cytochrome B large subunit
name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor
name: Integral membrane protein CII-3
name: QPs-1
name: DDB0231385
xref: UnificationXref6374
feature: FragmentFeature1172
cellular location: GO_0005743
comment: Reactome DB_ID: 5579514
display name: SDHC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231357
data source: Provenance1
name: Succinyl-CoA synthetase, betaA chain
name: DDB0231357
xref: UnificationXref6366
feature: FragmentFeature1171
cellular location: GO_0005759
comment: Reactome DB_ID: 5579526
display name: SUCLA2

(GlcNAc)2 (Man)5 (Asn)1
type: SmallMolecule
entity reference: CHEBI_59087
data source: Provenance1
xref: UnificationXref13422
xref: UnificationXref13423
cellular location: GO_0005796
comment: Reactome DB_ID: 964740

(GlcNAc)2 (Man)8 glycans
type: SmallMolecule
data source: Provenance1
member physical entity: (GlcNAc)2 (Man)8b
member physical entity: (GlcNAc)2 (Man)8a
member physical entity: (GlcNAc)2 (Man)8c
xref: UnificationXref13458
cellular location: GO_0005796
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588538

(GlcNAc)2 (Man)8b
type: SmallMolecule
entity reference: CHEBI_60628
data source: Provenance1
xref: UnificationXref13452
xref: UnificationXref13451
cellular location: GO_0005796
comment: Reactome DB_ID: 948008

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI_60627
data source: Provenance1
xref: UnificationXref13454
xref: UnificationXref13453
cellular location: GO_0005796
comment: Reactome DB_ID: 948029

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231397
data source: Provenance1
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
name: DDB0231397
xref: UnificationXref6390
feature: FragmentFeature1176
cellular location: GO_0005759
comment: Reactome DB_ID: 5579496
display name: FH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305262
data source: Provenance1
name: L-2-hydroxyglutarate dehydrogenase
name: DDB0305262
xref: UnificationXref6403
feature: FragmentFeature1177
cellular location: GO_0005743
comment: Reactome DB_ID: 5588168
display name: L2HGDH

(GlcNAc)3 (Man)3 (Asn)1
type: SmallMolecule
entity reference: CHEBI_60615
data source: Provenance1
xref: UnificationXref13480
xref: UnificationXref13481
cellular location: GO_0005796
comment: Reactome DB_ID: 975819

Zinc 2+
type: SmallMolecule
entity reference: CHEBI_29105
data source: Provenance1
xref: UnificationXref13483
xref: UnificationXref13482
cellular location: Golgi membrane
comment: Reactome DB_ID: 975815
display name: Zn2+

(GlcNAc)2 (Man)8c
type: SmallMolecule
entity reference: CHEBI_60629
data source: Provenance1
xref: UnificationXref13456
xref: UnificationXref13457
cellular location: GO_0005796
comment: Reactome DB_ID: 947996

(GlcNAc)2 (Man)7bc
type: SmallMolecule
entity reference: CHEBI_60637
data source: Provenance1
xref: UnificationXref13462
xref: UnificationXref13463
cellular location: GO_0005796
comment: Reactome DB_ID: 964828

(GlcNAc)3 (Man)5 (Asn)1
type: SmallMolecule
entity reference: CHEBI_60625
data source: Provenance1
xref: UnificationXref13469
xref: UnificationXref13470
cellular location: GO_0005796
comment: Reactome DB_ID: 964837

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

UDP
type: SmallMolecule
entity reference: CHEBI_17659
data source: Provenance1
xref: UnificationXref13471
xref: UnificationXref13472
cellular location: GO_0005796
comment: Reactome DB_ID: 205687

Abacavir transport and metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 212905.2
pathway component: REACT 219417.2
evidence: Evidence1243
xref: UnificationXref8474
xref: UnificationXref8473
pathway order: PathwayStep1222
pathway order: PathwayStep1217
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

ACC
type: Protein
data source: Provenance1
member physical entity: Protein904
member physical entity: DDB0230067
xref: UnificationXref6169
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583068

DDB0214955
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214955
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CALM_HUMAN
name: Calmodulin
xref: UnificationXref6191
feature: FragmentFeature1143
cellular location: GO_0005886
comment: Reactome DB_ID: 5585152
display name: CALM1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215407
data source: Provenance1
name: 2xPalmC-MyrG-NOS3
name: palmitylated, N-myristoylated eNOS
xref: UnificationXref6185
feature: ModificationFeature190
feature: FragmentFeature1142
feature: ModificationFeature188
feature: ModificationFeature189
cellular location: GO_0005886
comment: Reactome DB_ID: 5585150
display name: DDB0215407

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215407
data source: Provenance1
name: 2xPalmC-MyrG-NOS3
name: palmitylated, N-myristoylated eNOS
xref: UnificationXref6184
feature: ModificationFeature190
feature: FragmentFeature1141
feature: ModificationFeature188
feature: ModificationFeature189
cellular location: Golgi membrane
comment: Reactome DB_ID: 5585232
display name: DDB0215407

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215407
data source: Provenance1
name: DDB0215407
name: N-myristoylated eNOS (Gly2)
xref: UnificationXref6180
feature: FragmentFeature1140
feature: ModificationFeature188
cellular location: GO_0005829
comment: Reactome DB_ID: 5585170
display name: MyrG-NOS3

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI_17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref14603
xref: UnificationXref14602
cellular location: GO_0005788
comment: Reactome DB_ID: 983021
display name: L-Cys

phospho-2xPalmC-MyrG-p-S1177-NOS3
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215407
data source: Provenance1
xref: UnificationXref6199
feature: ModificationFeature190
feature: FragmentFeature1146
feature: ModificationFeature191
feature: ModificationFeature188
feature: ModificationFeature189
cellular location: GO_0005886
comment: Reactome DB_ID: 5585163

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Provenance1
xref: UnificationXref14605
xref: UnificationXref14604
cellular location: GO_0005788
comment: Reactome DB_ID: 983028
display name: L-Ser

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234150
data source: Provenance1
name: DDB0234150
name: LYPLA1
xref: UnificationXref6220
feature: FragmentFeature1147
cellular location: GO_0005829
comment: Reactome DB_ID: 5585238
display name: APT1

DDB0191163
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191163
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HSP90AA1
xref: UnificationXref6193
feature: FragmentFeature1144
cellular location: GO_0005886
comment: Reactome DB_ID: 5585157
display name: HSP90

2-Amino-3-methylbutyric acid
type: SmallMolecule
entity reference: CHEBI_16414
data source: Provenance1
name: L-Valine
xref: UnificationXref14601
xref: UnificationXref14600
cellular location: GO_0005788
comment: Reactome DB_ID: 983027
display name: L-Val

phospho-p-T308,S473-AKT1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191195
data source: Provenance1
xref: UnificationXref6195
feature: ModificationFeature92
feature: ModificationFeature93
feature: FragmentFeature1145
cellular location: GO_0005886
comment: Reactome DB_ID: 5585159

L-alpha-Alanine
type: SmallMolecule
entity reference: CHEBI_16977
data source: Provenance1
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref14642
xref: UnificationXref14643
cellular location: GO_0031905
comment: Reactome DB_ID: 1225808
display name: L-Ala

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI_16467
data source: Provenance1
name: L-Arginine
xref: UnificationXref14644
xref: UnificationXref14645
cellular location: GO_0031905
comment: Reactome DB_ID: 1225815
display name: L-Arg

glycine
type: SmallMolecule
entity reference: CHEBI_15428
data source: Provenance1
name: Aminoacetic acid
xref: UnificationXref14607
xref: UnificationXref14606
cellular location: GO_0005788
comment: Reactome DB_ID: 1225801
display name: Gly

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215407
data source: Provenance1
name: DDB0215407
name: N-myristoylated eNOS (Gly2)
xref: UnificationXref6224
feature: FragmentFeature1148
feature: ModificationFeature188
cellular location: Golgi membrane
comment: Reactome DB_ID: 5585172
display name: MyrG-NOS3

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: L-Leucine
member physical entity: L-serine
member physical entity: 2,6-diaminohexanoic acid
member physical entity: glycine
member physical entity: (S)-alpha-Amino-1H-imidazole-4-propionic acid
member physical entity: L-Isoleucine
member physical entity: L-Glutamine
member physical entity: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
member physical entity: 2-Amino-3-methylbutyric acid
member physical entity: L-alpha-Alanine
member physical entity: (S)-2-Amino-5-guanidinovaleric acid
member physical entity: L-Glutaminic acid
member physical entity: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
member physical entity: L-Asparagine
member physical entity: 2-aminosuccinic acid
member physical entity: L-Phenylalanine
member physical entity: L-Methionine
member physical entity: L-Threonine
member physical entity: 2-Pyrrolidinecarboxylic acid
xref: UnificationXref14682
cellular location: GO_0031905
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5588939

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI_16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref14651
xref: UnificationXref14650
cellular location: GO_0031905
comment: Reactome DB_ID: 1225819
display name: L-Glu

L-Asparagine
type: SmallMolecule
entity reference: L-Asparagine
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref14646
xref: UnificationXref14647
cellular location: GO_0031905
comment: Reactome DB_ID: 1225812
display name: L-Asn

2-aminosuccinic acid
type: SmallMolecule
entity reference: 2-aminosuccinic acid
data source: Provenance1
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref14648
xref: UnificationXref14649
cellular location: GO_0031905
comment: Reactome DB_ID: 1225816
display name: L-Asp

http://identifiers.org/pubmed/1968462
type: PublicationXref
id: 1968462
author: Edwards, PA
author: Kutsunai, SY
author: Wilkin, DJ
db: Pubmed
title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester
source: J Biol Chem 265:4607-14
year: 1990

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302416
data source: Provenance1
name: DDB0302416
xref: UnificationXref6235
feature: FragmentFeature1150
cellular location: Golgi membrane
comment: Reactome DB_ID: 5585243
display name: NOSIP

3-Ureidoisobutyrate
type: SmallMoleculeReference
name: 3-ureidoisobutyric acid
name: ChEBI:1670 3-ureidoisobutyric acid
xref: UnificationXref6849

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0302416
data source: Provenance1
name: DDB0302416
xref: UnificationXref6231
feature: FragmentFeature1149
cellular location: GO_0005829
comment: Reactome DB_ID: 5585229
display name: NOSIP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232952
data source: Provenance1
name: DDB0232952
name: 6-pyruvoyl tetrahydrobiopterin synthase
name: PTPS
name: PTPS_HUMAN
xref: UnificationXref6254
feature: FragmentFeature1152
cellular location: GO_0005829
comment: Reactome DB_ID: 5589321
display name: PTS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191399
data source: Provenance1
name: DDB0191399
name: GTP cyclohydrolase 1
name: GCH1_HUMAN
xref: UnificationXref6246
feature: FragmentFeature1151
cellular location: GO_0005829
comment: Reactome DB_ID: 5589298
display name: GCH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191275
data source: Provenance1
name: SPRE_HUMAN
name: DDB0191275
name: Sepiapterin reductase
xref: UnificationXref6268
feature: FragmentFeature1154
cellular location: GO_0005829
comment: Reactome DB_ID: 5589604
display name: SPR

phospho-p-S19-PTS
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232952
data source: Provenance1
xref: UnificationXref6256
feature: FragmentFeature1153
feature: ModificationFeature192
cellular location: GO_0005829
comment: Reactome DB_ID: 5589309

phospho-p-S213-SPR
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191275
data source: Provenance1
xref: UnificationXref6270
feature: ModificationFeature193
feature: FragmentFeature1155
cellular location: GO_0005829
comment: Reactome DB_ID: 5589317

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230192
data source: Provenance1
name: proX
name: E3-binding protein
name: DDB0230192
name: Pyruvate dehydrogenase protein X component, mitochondrial precursor
name: E3BP
name: ODPX_HUMAN
name: Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex
name: pyruvate dehydrogenase complex X component (E3 binding protein)
xref: UnificationXref6295
feature: FragmentFeature1156
cellular location: GO_0005759
comment: Reactome DB_ID: 5579749
display name: PDHX

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI_15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref14581
xref: UnificationXref14580
cellular location: GO_0005788
comment: Reactome DB_ID: 983019
display name: L-His

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215387
data source: Provenance1
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
name: ODP2_HUMAN
name: PBC
name: pyruvate dehydrogenase E2 subunit
name: PDC-E2
name: 2xLipo-DLAT
name: M2 antigen complex 70 kDa subunit
name: DDB0215387
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor
name: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis
xref: UnificationXref6298
feature: ModificationFeature194
feature: FragmentFeature1157
feature: ModificationFeature195
cellular location: GO_0005759
comment: Reactome DB_ID: 5579744
display name: E2

L-Isoleucine
type: SmallMolecule
entity reference: L-Isoleucine [ChEBI:17191]
data source: Provenance1
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref14582
xref: UnificationXref14583
cellular location: GO_0005788
comment: Reactome DB_ID: 983023
display name: L-Ile

Glycine cleavage system L protein
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216232
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0216232
name: Dihydrolipoamide dehydrogenase, mitochondrial
xref: UnificationXref6301
feature: FragmentFeature1158
cellular location: GO_0005759
comment: Reactome DB_ID: 5579309
display name: DLD

L-Leucine
type: SmallMolecule
entity reference: CHEBI_15603
data source: Provenance1
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref14585
xref: UnificationXref14584
cellular location: GO_0005788
comment: Reactome DB_ID: 983011
display name: L-Leu

p38MAPK events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1402
pathway component: BiochemicalReaction1403
evidence: Evidence2186
xref: UnificationXref13978
xref: UnificationXref13977
pathway order: PathwayStep2147
pathway order: PathwayStep2146
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: CHEBI_18019
data source: Provenance1
name: Lysine acid
name: L-Lysine
xref: UnificationXref14586
xref: UnificationXref14587
cellular location: GO_0005788
comment: Reactome DB_ID: 983020
display name: L-Lys

L-Methionine
type: SmallMolecule
entity reference: CHEBI_16643
data source: Provenance1
xref: UnificationXref14588
xref: UnificationXref14589
cellular location: GO_0005788
comment: Reactome DB_ID: 983010
display name: L-Met

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI_17295
data source: Provenance1
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref14590
xref: UnificationXref14591
cellular location: GO_0005788
comment: Reactome DB_ID: 983017
display name: L-Phe

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI_17203
data source: Provenance1
name: L-Proline
xref: UnificationXref14592
xref: UnificationXref14593
cellular location: GO_0005788
comment: Reactome DB_ID: 983013
display name: L-Pro

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref14594
xref: UnificationXref14595
cellular location: GO_0005788
comment: Reactome DB_ID: 983025
display name: L-Thr

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI_16828
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref14596
xref: UnificationXref14597
cellular location: GO_0005788
comment: Reactome DB_ID: 983016
display name: L-Trp

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: CHEBI_17895
data source: Provenance1
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref14598
xref: UnificationXref14599
cellular location: GO_0005788
comment: Reactome DB_ID: 983014
display name: L-Tyr

DDB0231591
type: Protein
entity reference: UniProt:DDB0231591
data source: Provenance1
name: Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
name: Note: the coordinates are copied over from Homo sapiens.
name: COQ2_HUMAN
xref: UnificationXref6024
feature: FragmentFeature1124
cellular location: GO_0005743
comment: Reactome DB_ID: 5590825
display name: COQ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231594
data source: Provenance1
name: DDB0231594
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6_HUMAN
xref: UnificationXref6037
feature: FragmentFeature1125
cellular location: GO_0005743
comment: Reactome DB_ID: 5590812
display name: COQ6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215370
data source: Provenance1
name: Neutral ceramidase
name: ASAH2_HUMAN
name: DDB0215370
xref: UnificationXref6006
feature: FragmentFeature1123
cellular location: GO_0005886
comment: Reactome DB_ID: 5589674
display name: ASAH2

(GlcNAc)2 (Man)2 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_59085
data source: Provenance1
xref: UnificationXref13223
xref: UnificationXref13222
cellular location: GO_0071458
comment: Reactome DB_ID: 449737

(GlcNAc)2 (Man)3 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53742
data source: Provenance1
xref: UnificationXref13229
xref: UnificationXref13230
cellular location: GO_0071458
comment: Reactome DB_ID: 449243

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI_15812
data source: Provenance1
xref: UnificationXref13285
xref: UnificationXref13284
cellular location: GO_0071556
comment: Reactome DB_ID: 532542
display name: DbGP

(GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_59093
data source: Provenance1
xref: UnificationXref13279
xref: UnificationXref13280
cellular location: GO_0071556
comment: Reactome DB_ID: 449371

UnificationXref12119
type: UnificationXref
id: DDB0231332
db: UniProt

(GlcNAc)2 (Man)8 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_59091
data source: Provenance1
xref: UnificationXref13272
xref: UnificationXref13271
cellular location: GO_0071556
comment: Reactome DB_ID: 449365

UnificationXref12118
type: UnificationXref
id: REACT_17784
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17784.1

(GlcNAc)2 (Man)7 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_59088
data source: Provenance1
xref: UnificationXref13263
xref: UnificationXref13264
cellular location: GO_0071556
comment: Reactome DB_ID: 449312

UnificationXref12117
type: UnificationXref
id: 379786
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379786

(GlcNAc)2 (Man)6 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53023
data source: Provenance1
xref: UnificationXref13254
xref: UnificationXref13253
cellular location: GO_0071556
comment: Reactome DB_ID: 449315

UnificationXref12116
type: UnificationXref
id: CHEBI:29155
db: ChEBI

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI_16214
data source: Provenance1
name: Dolichol phosphate
xref: UnificationXref13251
xref: UnificationXref13250
cellular location: GO_0071556
comment: Reactome DB_ID: 449311
display name: DOLP

UnificationXref12115
type: UnificationXref
id: REACT_15991
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15991.1

Dolichyl phosphate D-mannose
type: SmallMolecule
entity reference: CHEBI_15809
data source: Provenance1
name: Dolichyl D-mannosyl phosphate
xref: UnificationXref13249
xref: UnificationXref13248
cellular location: GO_0071556
comment: Reactome DB_ID: 449229
display name: DOLPman

UnificationXref12114
type: UnificationXref
id: 379758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379758

(GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53022
data source: Provenance1
xref: UnificationXref13242
xref: UnificationXref13241
cellular location: GO_0071556
comment: Reactome DB_ID: 449298

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
type: Pathway
data source: Provenance1
pathway component: REACT 211295.2
pathway component: REACT 241915.1
evidence: Evidence1802
xref: UnificationXref11399
xref: UnificationXref11398
pathway order: PathwayStep1748
pathway order: PathwayStep1768
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12113
type: UnificationXref
id: CHEBI:29178
db: ChEBI

(GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53022
data source: Provenance1
xref: UnificationXref13235
xref: UnificationXref13234
cellular location: GO_0071458
comment: Reactome DB_ID: 449332

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191246
data source: Provenance1
name: DDB0191246
name: G(s) alpha subunit
xref: UnificationXref6103
feature: FragmentFeature1130
cellular location: GO_0005886
comment: Reactome DB_ID: 5583040
display name: GNAS

UnificationXref12112
type: UnificationXref
id: REACT_217004
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_217004.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230131
data source: Provenance1
name: DDB0230131
name: G(s) alpha subunit
xref: UnificationXref6102
feature: FragmentFeature1129
cellular location: GO_0005886
comment: Reactome DB_ID: 5583039
display name: GNAS

UnificationXref12111
type: UnificationXref
id: 5585953
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585953

Homologues of GNAS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6107
cellular location: GO_0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5583044

UnificationXref12110
type: UnificationXref
id: 5585951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585951

Phospholipase C Beta (pancreatic beta cell)
type: Protein
data source: Provenance1
member physical entity: Protein946
member physical entity: Protein945
member physical entity: Protein944
xref: UnificationXref6090
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5586745
display name: PLC beta1,2,3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266669
data source: Provenance1
name: DDB0266669
name: COQ7_HUMAN
name: Ubiquinone biosynthesis protein COQ7 homolog
xref: UnificationXref6068
feature: FragmentFeature1128
cellular location: GO_0005743
comment: Reactome DB_ID: 5590833
display name: COQ7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231541
data source: Provenance1
name: COQ5_HUMAN
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
name: DDB0231541
xref: UnificationXref6061
feature: FragmentFeature1127
cellular location: GO_0005759
comment: Reactome DB_ID: 5590819
display name: COQ5

http://identifiers.org/pubmed/10092647
type: PublicationXref
id: 10092647
author: Wang, X
author: Nowatzke, W
author: Ramanadham, S
author: Ma, Z
author: Turk, J
db: Pubmed
title: Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1
source: J Biol Chem 274:9607-16
year: 1999

COQ3_HUMAN
type: Protein
entity reference: UniProt:DDB0231592
data source: Provenance1
name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial ecNumber2.1.1.114/ecNumber
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0231592
name: COQ3(?-369)
xref: UnificationXref6051
feature: FragmentFeature1126
cellular location: GO_0005759
comment: Reactome DB_ID: 5590806
display name: COQ3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230127
data source: Provenance1
name: DDB0230127
name: G(s) alpha subunit
xref: UnificationXref6104
feature: FragmentFeature1131
cellular location: GO_0005886
comment: Reactome DB_ID: 5583041
display name: GNAS

http://identifiers.org/pubmed/17170135
type: PublicationXref
id: 17170135
author: Li, JL
author: Gimeno, RE
author: Li, D
author: Tobin, JF
author: Cao, J
db: Pubmed
title: Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
source: Proc Natl Acad Sci U S A 103:19695-700
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216411
data source: Provenance1
name: DDB0216411
name: G(s) alpha subunit
xref: UnificationXref6105
feature: FragmentFeature1132
cellular location: GO_0005886
comment: Reactome DB_ID: 5583042
display name: GNAS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230129
data source: Provenance1
name: DDB0230129
name: G(s) alpha subunit
xref: UnificationXref6106
feature: FragmentFeature1133
cellular location: GO_0005886
comment: Reactome DB_ID: 5583043
display name: GNAS

Adenylyl cyclase (pancreatic beta cell)
type: Protein
data source: Provenance1
member physical entity: Protein556
member physical entity: Protein561
member physical entity: Protein560
xref: UnificationXref6109
cellular location: GO_0005886
comment: Reactome DB_ID: 5586242
comment: Converted from EntitySet in Reactome

Dolichol
type: SmallMolecule
entity reference: CHEBI_16091
data source: Provenance1
xref: UnificationXref13117
xref: UnificationXref13118
cellular location: GO_0071458
comment: Reactome DB_ID: 449221
display name: DCHOL

Dolichol diphosphate
type: SmallMolecule
entity reference: CHEBI_15750
data source: Provenance1
name: Dolichyl diphosphate
xref: UnificationXref13124
xref: UnificationXref13125
cellular location: GO_0071458
comment: Reactome DB_ID: 449744
display name: DOLDP

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: CHEBI_15873
data source: Provenance1
xref: UnificationXref13133
xref: UnificationXref13134
cellular location: GO_0005829
comment: Reactome DB_ID: 449701
display name: GlcN6P

N-acetyl-D-glucosaminyl-diphosphodolichol
type: SmallMolecule
entity reference: CHEBI_18278
data source: Provenance1
xref: UnificationXref13202
xref: UnificationXref13203
cellular location: GO_0071458
comment: Reactome DB_ID: 449222
display name: GlcNAcDOLDP

UnificationXref12129
type: UnificationXref
id: 5585896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585896

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI_15812
data source: Provenance1
xref: UnificationXref13191
xref: UnificationXref13192
cellular location: GO_0071458
comment: Reactome DB_ID: 532214
display name: DbGP

beta-D-mannosyldiacetylchitobiosyldiphosphodolichol
type: SmallMolecule
entity reference: CHEBI_18396
data source: Provenance1
xref: UnificationXref13216
xref: UnificationXref13215
cellular location: GO_0071458
comment: Reactome DB_ID: 449283
display name: MDCDD

N,N'-diacetylchitobiosyldiphosphodolichol
type: SmallMolecule
entity reference: CHEBI_18341
data source: Provenance1
xref: UnificationXref13205
xref: UnificationXref13206
cellular location: GO_0071458
comment: Reactome DB_ID: 449293
display name: N,N'-DCDOLDP

UnificationXref12126
type: UnificationXref
id: CHEBI:29160
db: ChEBI

N-Acetyl-D-glucosamine 1-phosphate
type: SmallMolecule
entity reference: CHEBI 7125
data source: Provenance1
xref: UnificationXref13150
xref: UnificationXref13151
cellular location: GO_0005829
comment: Reactome DB_ID: 532204
display name: AcGlcN1P

UnificationXref12125
type: UnificationXref
id: REACT_17479
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17479.1

N-Acetyl-D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: CHEBI_15784
data source: Provenance1
xref: UnificationXref13143
xref: UnificationXref13142
cellular location: GO_0005829
comment: Reactome DB_ID: 449703
display name: AcGlcN6P

UnificationXref12128
type: UnificationXref
id: REACT_17273
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17273.1

D-Mannose 1-phosphate
type: SmallMolecule
entity reference: CHEBI_35374
data source: Provenance1
xref: UnificationXref13169
xref: UnificationXref13168
cellular location: GO_0005829
comment: Reactome DB_ID: 532531
display name: Man1P

http://identifiers.org/pubmed/10371034
type: PublicationXref
id: 10371034
author: Rüegsegger, U
author: Wahle, E
db: Pubmed
title: 3'-End processing of pre-mRNA in eukaryotes.
source: FEMS Microbiol Rev 23:277-95
year: 1999

UnificationXref12127
type: UnificationXref
id: 379787
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379787

D-Mannose 6-phosphate
type: SmallMolecule
entity reference: CHEBI_17369
data source: Provenance1
xref: UnificationXref13161
xref: UnificationXref13162
cellular location: GO_0005829
comment: Reactome DB_ID: 532562
display name: Man6P

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0229349
data source: Provenance1
name: DDB0229349
name: LKB-1
xref: UnificationXref6158
feature: FragmentFeature1139
cellular location: GO_0005654
comment: Reactome DB_ID: 5583097
display name: STK11

UnificationXref12122
type: UnificationXref
id: REACT_210611
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210611.2

phospho-p-T172-PRKAA2
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215396
data source: Provenance1
xref: UnificationXref6155
feature: FragmentFeature1138
feature: ModificationFeature184
cellular location: GO_0005654
comment: Reactome DB_ID: 5583092

UnificationXref12121
type: UnificationXref
id: 5585820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585820

UnificationXref12124
type: UnificationXref
id: 379739
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379739

UnificationXref12123
type: UnificationXref
id: CHEBI:29174
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237813
data source: Provenance1
name: AMPK gamma2
name: DDB0237813
xref: UnificationXref6147
feature: FragmentFeature1135
cellular location: GO_0005654
comment: Reactome DB_ID: 5583059
display name: PRKAG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0201558
data source: Provenance1
name: ADP/ATP translocase 1
name: ADP,ATP carrier protein, heart/skeletal muscle isoform T1
name: SLC25A4
name: adenine nucleotide translocator 1
name: Adenine nucleotide translocator 1
name: ADP/ATP translocase 1 monomer
name: DDB0201558
xref: UnificationXref6123
feature: FragmentFeature1134
cellular location: GO_0005743
comment: Reactome DB_ID: 5583029
display name: ANT 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237814
data source: Provenance1
name: AMPK beta2
name: DDB0237814
xref: UnificationXref6149
feature: FragmentFeature1137
cellular location: GO_0005654
comment: Reactome DB_ID: 5583055
display name: PRKAB2

UnificationXref12120
type: UnificationXref
id: 5585818
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585818

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0215396
data source: Provenance1
name: DDB0215396
name: AMPK alpha2
xref: UnificationXref6148
feature: FragmentFeature1136
cellular location: GO_0005654
comment: Reactome DB_ID: 5583051
display name: PRKAA2

Homologues of SPHK2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0185181
xref: UnificationXref5893
cellular location: GO_0005829
comment: Reactome DB_ID: 5587014
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

(GlcNAc)2 (Man)7aa
type: SmallMolecule
entity reference: CHEBI_60640
data source: Provenance1
xref: UnificationXref13396
xref: UnificationXref13397
cellular location: GO_0005829
comment: Reactome DB_ID: 1022111

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI_60627
data source: Provenance1
xref: UnificationXref13393
xref: UnificationXref13394
cellular location: GO_0044322
comment: Reactome DB_ID: 912298

(GlcNAc)2 (Man)7aa
type: SmallMolecule
entity reference: CHEBI_60640
data source: Provenance1
xref: UnificationXref13390
xref: UnificationXref13389
cellular location: GO_0044322
comment: Reactome DB_ID: 912290

sphingosine-1-phosphate phosphatase
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5911
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587048
display name: SGPP

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI_16214
data source: Provenance1
name: Dolichol phosphate
xref: UnificationXref13380
xref: UnificationXref13381
cellular location: GO_0044322
comment: Reactome DB_ID: 912287
display name: DOLP

Transport of inorganic cations/anions and amino acids/oligopeptides
type: Pathway
data source: Provenance1
pathway component: REACT 208256.2
pathway component: REACT 240921.1
pathway component: REACT 207100.2
pathway component: REACT 205188.2
pathway component: REACT 216060.2
evidence: Evidence1523
xref: RelationshipXref1370
xref: UnificationXref10071
xref: UnificationXref10072
pathway order: PathwayStep1486
pathway order: PathwayStep1484
pathway order: PathwayStep1494
pathway order: PathwayStep1491
pathway order: PathwayStep1490
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

D-mannose
type: SmallMolecule
entity reference: CHEBI 4208
data source: Provenance1
xref: UnificationXref13419
xref: UnificationXref13420
cellular location: GO_0005796
comment: Reactome DB_ID: 964752
display name: Man

(GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI_59092
data source: Provenance1
xref: UnificationXref13417
xref: UnificationXref13416
cellular location: GO_0005796
comment: Reactome DB_ID: 915149

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI_60627
data source: Provenance1
xref: UnificationXref13402
xref: UnificationXref13401
cellular location: GO_0005829
comment: Reactome DB_ID: 1022112

DDB0230136
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LAG1 homolog, ceramide synthase 2
name: LASS2
xref: UnificationXref5898
feature: FragmentFeature1110
cellular location: GO_0005789
comment: Reactome DB_ID: 5587004
display name: CERS2

LAG1 homologs, ceramide synthases
type: Protein
data source: Provenance1
member physical entity: DDB0230136
xref: UnificationXref5903
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5587009
display name: LASS proteins

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220131
data source: Provenance1
name: sphingosine kinase 2
name: DDB0220131
xref: UnificationXref5892
feature: FragmentFeature1109
cellular location: GO_0005829
comment: Reactome DB_ID: 5587013
display name: SPHK2

DDB0185181
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185181
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: sphingosine kinase 2
xref: UnificationXref5891
feature: FragmentFeature1108
cellular location: GO_0005829
comment: Reactome DB_ID: 5587012
display name: SPHK2

DDB0230136
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LAG1 homolog, ceramide synthase 6
name: LASS6
xref: UnificationXref5902
feature: FragmentFeature1114
cellular location: GO_0005789
comment: Reactome DB_ID: 5587008
display name: CERS6

(Glc)1 (GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI_59080
data source: Provenance1
xref: UnificationXref13378
xref: UnificationXref13377
cellular location: GO_0044322
comment: Reactome DB_ID: 912286

DDB0230136
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LAG1 homolog, ceramide synthase 5
name: LASS5
xref: UnificationXref5901
feature: FragmentFeature1113
cellular location: GO_0005789
comment: Reactome DB_ID: 5587007
display name: CERS5

(GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI_59092
data source: Provenance1
xref: UnificationXref13375
xref: UnificationXref13374
cellular location: GO_0044322
comment: Reactome DB_ID: 912288

http://identifiers.org/pubmed/21540551
type: PublicationXref
id: 21540551
author: Matejas, V
author: Kispert, A
author: Casarin, A
author: Faul, C
author: Pertegato, V
author: Akman, S
author: Kusakabe, T
author: Wang, S
author: Santos-Ocaña, C
author: Krick, S
author: Doimo, M
author: Hildebrandt, F
author: Chernin, G
author: Vega-Warner, V
author: McLaughlin, HM
author: Nürnberg, G
author: Navas, P
author: Chaki, M
author: Schoeb, DS
author: Becker, C
author: Saisawat, P
author: Heeringa, SF
author: Varpizen, S
author: Prokisch, H
author: Wiggins, RC
author: Nürnberg, P
author: Beissert, A
author: Zhou, W
author: Bakkaloglu, A
author: Ji, Z
author: Xie, LX
author: Hinkes, B
author: Bakkaloglu, SA
author: Salviati, L
author: Reiser, J
author: Vlangos, CN
author: Mir, S
author: Airik, R
author: Topaloglu, R
author: Sloan, AJ
author: Rötig, A
author: Trevisson, E
author: Gbadegesin, R
author: Raphael, Y
author: Zenker, M
author: Clarke, CF
author: Ozaltin, F
author: Soliman, NA
author: Müller, D
author: Berdeli, A
author: Ashraf, S
author: Killen, PD
author: Mundel, P
author: Hurd, TW
author: Giorgi, G
author: Ovunc, B
db: Pubmed
title: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
source: J Clin Invest 121:2013-24
year: 2011

DDB0230136
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LASS4
name: LAG1 homolog, ceramide synthase 4
xref: UnificationXref5900
feature: FragmentFeature1112
cellular location: GO_0005789
comment: Reactome DB_ID: 5587006
display name: CERS4

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI_15812
data source: Provenance1
xref: UnificationXref13372
xref: UnificationXref13371
cellular location: GO_0044322
comment: Reactome DB_ID: 912292
display name: DbGP

DDB0230136
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0230136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LASS3
name: LAG1 homolog, ceramide synthase 3
xref: UnificationXref5899
feature: FragmentFeature1111
cellular location: GO_0005789
comment: Reactome DB_ID: 5587005
display name: CERS3

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216187
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 1
name: DDB0216187
xref: UnificationXref5909
feature: FragmentFeature1115
cellular location: GO_0005789
comment: Reactome DB_ID: 5587046
display name: SGPP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216187
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 2
name: DDB0216187
xref: UnificationXref5910
feature: FragmentFeature1116
cellular location: GO_0005789
comment: Reactome DB_ID: 5587047
display name: SGPP2

(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_59081
data source: Provenance1
xref: UnificationXref13287
xref: UnificationXref13288
cellular location: GO_0071556
comment: Reactome DB_ID: 449649

http://identifiers.org/pubmed/3391615
type: PublicationXref
id: 3391615
author: Robertson, D A
author: Baker, E G
author: Morris, C P
author: Hopwood, J J
author: Callen, D F
db: Pubmed
title: Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
source: Hum. Genet. 79:175-8
year: 1988

UnificationXref12104
type: UnificationXref
id: REACT_15638
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15638.1

(Glc)2 (GlcNAc)2 (Man)9 (Asn)1
type: SmallMolecule
entity reference: CHEBI_59082
data source: Provenance1
xref: UnificationXref13315
xref: UnificationXref13314
cellular location: GO_0005788
comment: Reactome DB_ID: 532677

UnificationXref12103
type: UnificationXref
id: 379766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379766

(Glc)3 (GlcNAc)2 (Man)9 (Asn)1
type: SmallMolecule
entity reference: CHEBI_59084
data source: Provenance1
xref: UnificationXref13311
xref: UnificationXref13310
cellular location: GO_0071556
comment: Reactome DB_ID: 532673

UnificationXref12106
type: UnificationXref
id: 379784
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379784

(Glc)1 (GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI_59080
data source: Provenance1
xref: UnificationXref13324
xref: UnificationXref13325
cellular location: GO_0005788
comment: Reactome DB_ID: 532679

UnificationXref12105
type: UnificationXref
id: CHEBI:29156
db: ChEBI

alpha-D-glucose
type: SmallMolecule
entity reference: CHEBI_17925
data source: Provenance1
xref: UnificationXref13317
xref: UnificationXref13318
cellular location: GO_0005788
comment: Reactome DB_ID: 113780
display name: Glc

UnificationXref12108
type: UnificationXref
id: DDB0231313
db: UniProt

(GlcNAc)2 (Man)8b
type: SmallMolecule
entity reference: CHEBI_64048
data source: Provenance1
xref: UnificationXref13354
xref: UnificationXref13355
cellular location: GO_0005788
comment: Reactome DB_ID: 901046

UnificationXref12107
type: UnificationXref
id: REACT_18164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18164.1

(Glc)1 (GlcNAc)2 (Man)8b
type: SmallMolecule
entity reference: CHEBI_64046
data source: Provenance1
xref: UnificationXref13347
xref: UnificationXref13346
cellular location: GO_0005788
comment: Reactome DB_ID: 901055

(GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI_59092
data source: Provenance1
xref: UnificationXref13361
xref: UnificationXref13360
cellular location: GO_0005788
comment: Reactome DB_ID: 548872

UnificationXref12109
type: UnificationXref
id: 5585950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585950

(GlcNAc)2 (Man)8c
type: SmallMolecule
entity reference: CHEBI_64052
data source: Provenance1
xref: UnificationXref13358
xref: UnificationXref13357
cellular location: GO_0005788
comment: Reactome DB_ID: 901037

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233869
data source: Provenance1
name: DDB0233869
name: AGAL_HUMAN
name: Alpha-galactosidase A
xref: UnificationXref5965
feature: FragmentFeature1118
cellular location: GO_0043202
comment: Reactome DB_ID: 5589655
display name: GLA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214888
data source: Provenance1
name: DDB0214888
name: PXLP-SGPL1
name: sphingosine-1-phosphate lyase 1
xref: UnificationXref5918
feature: FragmentFeature1117
feature: ModificationFeature187
cellular location: GO_0005789
comment: Reactome DB_ID: 5587055
display name: SGPL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216178
data source: Provenance1
name: DDB0216178
name: ASM_HUMAN
name: Sphingomyelin phosphodiesterase
xref: UnificationXref5979
feature: FragmentFeature1119
cellular location: GO_0043202
comment: Reactome DB_ID: 5589662
display name: SMPD1

Homologues of SMPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5982
cellular location: GO_0043202
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589667

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0184404
data source: Provenance1
name: GBA2_HUMAN
name: Non-lysosomal glucosylceramidase
name: DDB0184404
xref: UnificationXref5990
feature: FragmentFeature1121
cellular location: GO_0005886
comment: Reactome DB_ID: 5590532
display name: GBA2

UnificationXref12100
type: UnificationXref
id: 5585914
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585914

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232049
data source: Provenance1
name: DDB0232049
name: ASM_HUMAN
name: Sphingomyelin phosphodiesterase
xref: UnificationXref5981
feature: FragmentFeature1120
cellular location: GO_0043202
comment: Reactome DB_ID: 5589666
display name: SMPD1

ASAH2-like proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6007
cellular location: GO_0005886
comment: Reactome DB_ID: 5589675
comment: Converted from EntitySet in Reactome

UnificationXref12102
type: UnificationXref
id: CHEBI:29176
db: ChEBI

(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53019
data source: Provenance1
xref: UnificationXref13302
xref: UnificationXref13301
cellular location: GO_0071556
comment: Reactome DB_ID: 449651

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232174
data source: Provenance1
name: DDB0232174
name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
name: ENPP7_HUMAN
xref: UnificationXref5997
feature: FragmentFeature1122
cellular location: GO_0005886
comment: Reactome DB_ID: 5589744
display name: ENPP7

UnificationXref12101
type: UnificationXref
id: REACT_260291
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260291.1

(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI_53020
data source: Provenance1
xref: UnificationXref13294
xref: UnificationXref13295
cellular location: GO_0071556
comment: Reactome DB_ID: 449638

SequenceSite4300
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4301
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite4302
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite4303
type: SequenceSite
position status: EQUAL
sequence position: 1

MPS IIIA - Sanfilippo syndrome A
type: Pathway
data source: Provenance1
pathway component: REACT 209706.2
evidence: Evidence262
xref: UnificationXref2117
xref: UnificationXref2118
pathway order: PathwayStep242
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/23349863
type: PublicationXref
id: 23349863
author: Nguyen, Kevin
author: Raynes, Rachel
author: Mendez, Jamie E
author: Westerheide, Sandy D
author: Pombier, Kathleen M
author: Brunquell, Jessica
db: Pubmed
title: The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
source: PLoS ONE 8:e54364
year: 2013

IRS-related events
type: Pathway
data source: Provenance1
pathway component: REACT 209797.2
evidence: Evidence2173
xref: UnificationXref13859
xref: UnificationXref13860
pathway order: PathwayStep2134
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Telomere C-strand (Lagging Strand) Synthesis
type: Pathway
data source: Provenance1
pathway component: REACT 208800.2
pathway component: REACT 227238.2
evidence: Evidence1460
xref: RelationshipXref1327
xref: UnificationXref9550
xref: UnificationXref9551
pathway order: PathwayStep1431
pathway order: PathwayStep1435
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234209
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: KIAA0981
name: DDB0234209
xref: UnificationXref5581
feature: FragmentFeature1090
cellular location: GO_0031902
comment: Reactome DB_ID: 5589875
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234209
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: KIAA0981
name: DDB0234209
xref: UnificationXref5544
feature: FragmentFeature1082
cellular location: GO_0031901
comment: Reactome DB_ID: 5590013
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref5579
feature: FragmentFeature1088
cellular location: GO_0031902
comment: Reactome DB_ID: 5589879
display name: TRX

DDB0205575
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref5580
feature: FragmentFeature1089
cellular location: GO_0031902
comment: Reactome DB_ID: 5589871
display name: FIG4

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204242
data source: Provenance1
name: DDB0204242
name: KIAA1073
xref: UnificationXref5555
feature: FragmentFeature1086
cellular location: GO_0005829
comment: Reactome DB_ID: 5589834
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238873
data source: Provenance1
name: DDB0238873
name: KIAA1073
xref: UnificationXref5556
feature: FragmentFeature1087
cellular location: GO_0005829
comment: Reactome DB_ID: 5589835
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190271
data source: Provenance1
name: DDB0190271
name: KIAA1073
xref: UnificationXref5553
feature: FragmentFeature1084
cellular location: GO_0005829
comment: Reactome DB_ID: 5589832
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238869
data source: Provenance1
name: KIAA1073
name: DDB0238869
xref: UnificationXref5554
feature: FragmentFeature1085
cellular location: GO_0005829
comment: Reactome DB_ID: 5589833
display name: MTMR2

Homologues of MTMR2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5557
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589836

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190143
data source: Provenance1
name: KIAA1073
name: DDB0190143
xref: UnificationXref5552
feature: FragmentFeature1083
cellular location: GO_0005829
comment: Reactome DB_ID: 5589831
display name: MTMR2

DDB0205575
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref5543
feature: FragmentFeature1081
cellular location: GO_0031901
comment: Reactome DB_ID: 5590012
display name: FIG4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref5542
feature: FragmentFeature1080
cellular location: GO_0031901
comment: Reactome DB_ID: 5590014
display name: TRX

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

http://identifiers.org/pubmed/7913309
type: PublicationXref
id: 7913309
author: Rokosz, LL
author: Cueto, MA
author: Butkiewicz, EA
author: Hermes, JD
author: Boulton, DA
author: Sanyal, G
author: Lachance, PA
db: Pubmed
title: Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
source: Arch Biochem Biophys 312:1-13
year: 1994

Homologues of MTMR6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5510
cellular location: GO_0005829
comment: Reactome DB_ID: 5589935
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266510
data source: Provenance1
name: DDB0266510
xref: UnificationXref5507
feature: FragmentFeature1077
cellular location: GO_0005829
comment: Reactome DB_ID: 5589933
display name: MTMR6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216866
data source: Provenance1
name: DDB0216866
xref: UnificationXref5509
feature: FragmentFeature1078
cellular location: GO_0005829
comment: Reactome DB_ID: 5589934
display name: MTMR6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0219484
data source: Provenance1
name: DDB0219484
name: C3orf29
xref: UnificationXref5512
feature: FragmentFeature1079
cellular location: GO_0005829
comment: Reactome DB_ID: 5589939
display name: MTMR14

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190271
data source: Provenance1
name: DDB0190271
xref: UnificationXref5501
feature: FragmentFeature1073
cellular location: GO_0005829
comment: Reactome DB_ID: 5589928
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238869
data source: Provenance1
name: DDB0238869
xref: UnificationXref5502
feature: FragmentFeature1074
cellular location: GO_0005829
comment: Reactome DB_ID: 5589929
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204242
data source: Provenance1
name: DDB0204242
xref: UnificationXref5503
feature: FragmentFeature1075
cellular location: GO_0005829
comment: Reactome DB_ID: 5589930
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238873
data source: Provenance1
name: DDB0238873
xref: UnificationXref5504
feature: FragmentFeature1076
cellular location: GO_0005829
comment: Reactome DB_ID: 5589931
display name: MTMR1

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

http://identifiers.org/pubmed/9852097
type: PublicationXref
id: 9852097
author: Kerr, TA
author: Russell, DW
author: Li, WP
author: Sakai, J
author: Lund, EG
db: Pubmed
title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
source: J Biol Chem 273:34316-27
year: 1998

http://identifiers.org/pubmed/12176987
type: PublicationXref
id: 12176987
author: Tanabe, K
author: Tanaka, AR
author: Ueda, K
author: Morita, M
author: Kurisu, M
author: Matsuo, M
author: Kasiwayama, Y
author: Kioka, N
author: Imanaka, T
author: Amachi, T
db: Pubmed
title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
source: J Biol Chem 277:40142-7
year: 2002

Homologues of MTMR7
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5591
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589845

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0266510
data source: Provenance1
name: DDB0266510
xref: UnificationXref5589
feature: FragmentFeature1091
cellular location: GO_0005829
comment: Reactome DB_ID: 5589840
display name: MTMR7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216866
data source: Provenance1
name: DDB0216866
xref: UnificationXref5590
feature: FragmentFeature1092
cellular location: GO_0005829
comment: Reactome DB_ID: 5589844
display name: MTMR7

DDB0185377
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185377
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PGFS_HUMAN
name: Prostamide/prostaglandin F synthase
name: C1orf93
xref: UnificationXref5741
feature: FragmentFeature1093
cellular location: GO_0005829
comment: Reactome DB_ID: 5590759
display name: FAM213B

DDB0305274
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305274
data source: Provenance1
name: PTGES3
name: Note: the coordinates are copied over from Homo sapiens.
name: Prostaglandin E synthase 3
xref: UnificationXref5748
feature: FragmentFeature1094
cellular location: GO_0005829
comment: Reactome DB_ID: 5585553
display name: cPGES

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191291
data source: Provenance1
name: DDB0191291
name: Leukotriene A-4 hydrolase-1
name: LKHA4_HUMAN
xref: UnificationXref5760
feature: FragmentFeature1095
cellular location: GO_0005829
comment: Reactome DB_ID: 5585581
display name: LTA4H

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214940
data source: Provenance1
name: LOX15_HUMAN
name: Arachidonate 15-lipoxygenase
name: DDB0214940
xref: UnificationXref5775
feature: FragmentFeature1096
cellular location: GO_0005829
comment: Reactome DB_ID: 5590785
display name: ALOX15

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214940
data source: Provenance1
name: LX15B_HUMAN
name: Arachidonate 15-lipoxygenase B
name: DDB0214940
xref: UnificationXref5784
feature: FragmentFeature1097
cellular location: GO_0005829
comment: Reactome DB_ID: 5590790
display name: ALOX15B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214940
data source: Provenance1
name: LX12B_HUMAN
name: DDB0214940
name: Arachidonate 12-lipoxygenase, 12R-type
xref: UnificationXref5794
feature: FragmentFeature1098
cellular location: GO_0005829
comment: Reactome DB_ID: 5590779
display name: ALOX12B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0214940
data source: Provenance1
name: Arachidonate 12-lipoxygenase, 12S-type
name: DDB0214940
name: LOX12_HUMAN
xref: UnificationXref5801
feature: FragmentFeature1099
cellular location: GO_0005829
comment: Reactome DB_ID: 5590767
display name: ALOX12

http://identifiers.org/pubmed/7816143
type: PublicationXref
id: 7816143
author: Glover, JN
author: Harrison, SC
db: Pubmed
title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
source: Nature 373:257-61
year: 1995

SequenceSite4373
type: SequenceSite
position status: EQUAL
sequence position: 923

SequenceSite4374
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4375
type: SequenceSite
position status: EQUAL
sequence position: 747

SequenceSite4376
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

SequenceSite4377
type: SequenceSite
position status: EQUAL
sequence position: 1374

SequenceSite4378
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4379
type: SequenceSite
position status: EQUAL
sequence position: 347

SequenceSite4370
type: SequenceSite
position status: EQUAL
sequence position: 923

SequenceSite4371
type: SequenceSite
position status: EQUAL
sequence position: 454

SequenceSite4372
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4386
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4387
type: SequenceSite
position status: EQUAL
sequence position: 1298

SequenceSite4384
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4385
type: SequenceSite
position status: EQUAL
sequence position: 1210

SequenceSite4388
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/20154325
type: PublicationXref
id: 20154325
author: Beese, Lorena S
author: Tsai, Miaw-Sheue
author: Genschel, Jochen
author: Modrich, Paul
author: Iyer, Ravi R
author: Pluciennik, Anna
db: Pubmed
title: MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta
source: J. Biol. Chem. 285:11730-9
year: 2010

SequenceSite4389
type: SequenceSite
position status: EQUAL
sequence position: 522

SequenceSite4382
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4383
type: SequenceSite
position status: EQUAL
sequence position: 399

SequenceSite4380
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4381
type: SequenceSite
position status: EQUAL
sequence position: 334

http://identifiers.org/pubmed/12176931
type: PublicationXref
id: 12176931
author: Lamond, AI
author: Ryder, U
author: Rappsilber, J
author: Mann, M
db: Pubmed
title: Large-scale proteomic analysis of the human spliceosome.
source: Genome Res 12:1231-45
year: 2002

SequenceSite4349
type: SequenceSite
position status: EQUAL
sequence position: 646

SequenceSite4348
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4355
type: SequenceSite
position status: EQUAL
sequence position: 646

SequenceSite4356
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4357
type: SequenceSite
position status: EQUAL
sequence position: 646

SequenceSite4358
type: SequenceSite
position status: EQUAL
sequence position: 230

SequenceSite4351
type: SequenceSite
position status: EQUAL
sequence position: 646

SequenceSite4352
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4353
type: SequenceSite
position status: EQUAL
sequence position: 646

SequenceSite4354
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4350
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/11274057
type: PublicationXref
id: 11274057
author: Jiricny, J
author: Kleczkowska, H E
author: Lettieri, T
author: Marra, G
db: Pubmed
title: hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
source: Genes Dev. 15:724-36
year: 2001

SequenceSite4359
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12496762
type: PublicationXref
id: 12496762
author: Yamaguchi, Yu
author: Nguyen, Louis N
author: Murai, Keith K
author: Pasquale, Elena B
author: Irie, Fumitoshi
db: Pubmed
title: Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
source: Nat. Neurosci. 6:153-60
year: 2003

SequenceSite4368
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4369
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4366
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4367
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4364
type: SequenceSite
position status: EQUAL
sequence position: 303

SequenceSite4365
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4362
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4363
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4360
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4361
type: SequenceSite
position status: EQUAL
sequence position: 307

http://identifiers.org/pubmed/12807903
type: PublicationXref
id: 12807903
author: Nagai, M
author: Sudol, M
author: Navin, NE
author: Komuro, A
db: Pubmed
title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
source: J Biol Chem 278:33334-41
year: 2003

SequenceSite4326
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231997
type: ProteinReference
xref: UnificationXref4390
organism: http://identifiers.org/taxonomy/44689

SequenceSite4327
type: SequenceSite
position status: EQUAL
sequence position: 2549

SequenceSite4328
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:DDB0231999
type: ProteinReference
xref: UnificationXref13923
organism: http://identifiers.org/taxonomy/44689

SequenceSite4329
type: SequenceSite
position status: EQUAL
sequence position: 641

UniProt:DDB0231990
type: ProteinReference
xref: UnificationXref10488
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231991
type: ProteinReference
xref: UnificationXref10468
organism: http://identifiers.org/taxonomy/44689

SequenceSite4330
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4332
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4331
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4334
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4333
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4336
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4335
type: SequenceSite
position status: EQUAL
sequence position: 641

UniProt:DDB0231989
type: ProteinReference
xref: UnificationXref10482
organism: http://identifiers.org/taxonomy/44689

SequenceSite4339
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4337
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4338
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231983
type: ProteinReference
xref: UnificationXref10490
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231982
type: ProteinReference
xref: UnificationXref10476
organism: http://identifiers.org/taxonomy/44689

UniProt:DDB0231981
type: ProteinReference
xref: UnificationXref10494
organism: http://identifiers.org/taxonomy/44689

SequenceSite4343
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4342
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4341
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4340
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4347
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4346
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4345
type: SequenceSite
position status: EQUAL
sequence position: 641

SequenceSite4344
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17891149
type: PublicationXref
id: 17891149
author: Fasshauer, D
author: Riedel, D
author: Jahn, Reinhard
author: Radhakrishnan, A
author: Stein, A
db: Pubmed
title: Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
source: Nat Struct Mol Biol 14:904-11
year: 2007

UniProt:DDB0231972
type: ProteinReference
xref: UnificationXref10478
organism: http://identifiers.org/taxonomy/44689

SequenceSite4308
type: SequenceSite
position status: EQUAL
sequence position: 462

UniProt:DDB0231971
type: ProteinReference
xref: UnificationXref10484
organism: http://identifiers.org/taxonomy/44689

SequenceSite4309
type: SequenceSite
position status: EQUAL
sequence position: 1

Molybdopterin
type: SmallMoleculeReference
name: Molybdopterin [ChEBI:6969]
xref: UnificationXref3124

UniProt:DDB0231976
type: ProteinReference
xref: UnificationXref10480
organism: http://identifiers.org/taxonomy/44689

SequenceSite4304
type: SequenceSite
position status: EQUAL
sequence position: 529

UniProt:DDB0231975
type: ProteinReference
xref: UnificationXref13209
organism: http://identifiers.org/taxonomy/44689

SequenceSite4305
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231978
type: ProteinReference
xref: UnificationXref10474
organism: http://identifiers.org/taxonomy/44689

SequenceSite4306
type: SequenceSite
position status: EQUAL
sequence position: 462

SequenceSite4307
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:DDB0231970
type: ProteinReference
xref: UnificationXref10492
organism: http://identifiers.org/taxonomy/44689

SequenceSite4312
type: SequenceSite
position status: EQUAL
sequence position: 160

Golgi membrane
type: CellularLocationVocabulary
xref: UnificationXref1962

SequenceSite4311
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4314
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4313
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4310
type: SequenceSite
position status: EQUAL
sequence position: 529

UniProt:DDB0231963
type: ProteinReference
xref: UnificationXref10472
organism: http://identifiers.org/taxonomy/44689

SequenceSite4319
type: SequenceSite
position status: EQUAL
sequence position: 326

SequenceSite4317
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4318
type: SequenceSite
position status: EQUAL
sequence position: 724

SequenceSite4315
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4316
type: SequenceSite
position status: EQUAL
sequence position: 732

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

SequenceSite4325
type: SequenceSite
position status: EQUAL
sequence position: 1335

SequenceSite4324
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4323
type: SequenceSite
position status: EQUAL
sequence position: 326

SequenceSite4322
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4321
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite4320
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref12257
type: UnificationXref
id: 379715
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379715

UnificationXref12258
type: UnificationXref
id: REACT_15813
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15813.1

UnificationXref12259
type: UnificationXref
id: 379698
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379698

UnificationXref12250
type: UnificationXref
id: REACT_15719
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15719.1

UnificationXref12251
type: UnificationXref
id: 379718
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379718

UnificationXref12252
type: UnificationXref
id: REACT_16009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16009.1

UnificationXref12253
type: UnificationXref
id: DDB0231334
db: UniProt

UnificationXref12254
type: UnificationXref
id: 5586116
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586116

UnificationXref12255
type: UnificationXref
id: 5586118
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586118

UnificationXref12256
type: UnificationXref
id: REACT_227730
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227730.2

1-Acyl-sn-glycerol-3-phosphocholine
type: SmallMolecule
entity reference: CHEBI_17504
data source: Provenance1
name: 1-Acylglycero-3-phosphocholine
name: 2-Lysophosphatidylcholine
name: 1-Acyl-sn-glycero-3-phosphocholine
xref: UnificationXref14980
xref: UnificationXref14979
cellular location: GO_0005789
comment: Reactome DB_ID: 428981
display name: LPC

c-di-AMP
type: SmallMolecule
entity reference: CHEBI_47037
data source: Provenance1
xref: UnificationXref14865
xref: UnificationXref14864
cellular location: GO_0005829
comment: Reactome DB_ID: 3134845

Phosphatidyl choline
type: SmallMolecule
entity reference: CHEBI_16110
data source: Provenance1
xref: UnificationXref14956
xref: UnificationXref14957
cellular location: GO_0005886
comment: Reactome DB_ID: 429802
display name: PC

UnificationXref12268
type: UnificationXref
id: 379713
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379713

3',5'-cyclic di-GMP
type: SmallMolecule
entity reference: CHEBI_49537
data source: Provenance1
xref: UnificationXref14862
xref: UnificationXref14861
cellular location: GO_0005829
comment: Reactome DB_ID: 2395973
display name: c-di-GMP

UnificationXref12269
type: UnificationXref
id: REACT_17617
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17617.1

1,2-Diacyl-sn-glycero-3-phosphocholine
type: SmallMolecule
entity reference: CHEBI_16110
data source: Provenance1
name: Phosphatidyl-N-trimethylethanolamine
name: Choline phosphatide
name: Phosphatidylcholine
xref: UnificationXref14976
xref: UnificationXref14975
cellular location: GO_0005789
comment: Reactome DB_ID: 428980
display name: Lecithin

Arachidonic acid
type: SmallMolecule
entity reference: CHEBI_15843
data source: Provenance1
xref: UnificationXref14978
xref: UnificationXref14977
cellular location: GO_0005788
comment: Reactome DB_ID: 140356

Phosphatidic acid
type: SmallMolecule
entity reference: CHEBI_16337
data source: Provenance1
xref: UnificationXref14958
xref: UnificationXref14959
cellular location: GO_0005886
comment: Reactome DB_ID: 1602448
display name: PA

phys-ent-participant97857
type: SmallMolecule
entity reference: Choline
data source: Provenance1
name: phys-ent-participant35962
name: phys-ent-participant92341
name: phys-ent-participant36724
name: phys-ent-participant59676
name: phys-ent-participant36150
xref: UnificationXref14961
xref: UnificationXref14962
cellular location: GO_0005829
comment: Reactome DB_ID: 2263486
display name: choline

UnificationXref12262
type: UnificationXref
id: 5586122
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586122

UnificationXref12263
type: UnificationXref
id: 5586123
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586123

UnificationXref12260
type: UnificationXref
id: REACT_16074
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16074.1

UnificationXref12261
type: UnificationXref
id: DDB0231311
db: UniProt

UnificationXref12266
type: UnificationXref
id: 379714
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379714

UnificationXref12267
type: UnificationXref
id: REACT_15769
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15769.1

UnificationXref12264
type: UnificationXref
id: 5586125
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586125

UnificationXref12265
type: UnificationXref
id: REACT_203528
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203528.2

UnificationXref12270
type: UnificationXref
id: DDB0231320
db: UniProt

DEAD box protein 41 ligand
type: SmallMolecule
data source: Provenance1
member physical entity: c-di-AMP
member physical entity: 3',5'-cyclic di-GMP
xref: UnificationXref14866
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5591657
display name: DDX41 ligand

N-epsilon-(1-(1-carboxy)ethyl)lysine
type: SmallMolecule
entity reference: CHEBI_60125
data source: Provenance1
xref: UnificationXref14849
xref: UnificationXref14850
cellular location: GO_0005576
comment: Reactome DB_ID: 938699

N(6)-carboxymethyl-lysine
type: SmallMolecule
entity reference: CHEBI_53014
data source: Provenance1
xref: UnificationXref14847
xref: UnificationXref14846
cellular location: GO_0005576
comment: Reactome DB_ID: 879473
display name: NECML

AGE adducts
type: SmallMolecule
data source: Provenance1
member physical entity: N-epsilon-(1-(1-carboxy)ethyl)lysine
member physical entity: N(6)-carboxymethyl-lysine
xref: UnificationXref14851
cellular location: GO_0005576
comment: Reactome DB_ID: 5588120
comment: Converted from EntitySet in Reactome

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI_17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref14677
xref: UnificationXref14676
cellular location: GO_0031905
comment: Reactome DB_ID: 1225807
display name: L-Cys

L-serine
type: SmallMolecule
entity reference: L-Serine
data source: Provenance1
xref: UnificationXref14679
xref: UnificationXref14678
cellular location: GO_0031905
comment: Reactome DB_ID: 1225805
display name: L-Ser

glycine
type: SmallMolecule
entity reference: CHEBI_15428
data source: Provenance1
name: Aminoacetic acid
xref: UnificationXref14681
xref: UnificationXref14680
cellular location: GO_0031905
comment: Reactome DB_ID: 1225824
display name: Gly

Peptide
type: SmallMolecule
entity reference: CHEBI_16670
data source: Provenance1
xref: UnificationXref14844
xref: UnificationXref14843
cellular location: GO_0005576
comment: Reactome DB_ID: 879484

UnificationXref12279
type: UnificationXref
id: 5586098
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586098

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: CHEBI_17895
data source: Provenance1
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref14672
xref: UnificationXref14673
cellular location: GO_0031905
comment: Reactome DB_ID: 1225817
display name: L-Tyr

2-Amino-3-methylbutyric acid
type: SmallMolecule
entity reference: CHEBI_16414
data source: Provenance1
name: L-Valine
xref: UnificationXref14675
xref: UnificationXref14674
cellular location: GO_0031905
comment: Reactome DB_ID: 1225820
display name: L-Val

UnificationXref12275
type: UnificationXref
id: REACT_15650
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15650.1

UnificationXref12276
type: UnificationXref
id: 379744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379744

UnificationXref12277
type: UnificationXref
id: REACT_15607
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15607.1

UnificationXref12278
type: UnificationXref
id: DDB0231322
db: UniProt

UnificationXref12271
type: UnificationXref
id: 5586049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586049

UnificationXref12272
type: UnificationXref
id: 5586051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586051

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

UnificationXref12273
type: UnificationXref
id: REACT_216727
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_216727.2

UnificationXref12274
type: UnificationXref
id: 379754
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379754

UnificationXref12281
type: UnificationXref
id: REACT_218002
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_218002.2

UnificationXref12280
type: UnificationXref
id: 5586100
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586100

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI_16828
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref14671
xref: UnificationXref14670
cellular location: GO_0031905
comment: Reactome DB_ID: 1225803
display name: L-Trp

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI_17295
data source: Provenance1
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref14664
xref: UnificationXref14665
cellular location: GO_0031905
comment: Reactome DB_ID: 1225811
display name: L-Phe

L-Methionine
type: SmallMolecule
entity reference: CHEBI_16643
data source: Provenance1
xref: UnificationXref14662
xref: UnificationXref14663
cellular location: GO_0031905
comment: Reactome DB_ID: 1225822
display name: L-Met

L-Threonine
type: SmallMolecule
entity reference: CHEBI_16857
data source: Provenance1
xref: UnificationXref14668
xref: UnificationXref14669
cellular location: GO_0031905
comment: Reactome DB_ID: 1225814
display name: L-Thr

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI_17203
data source: Provenance1
name: L-Proline
xref: UnificationXref14666
xref: UnificationXref14667
cellular location: GO_0031905
comment: Reactome DB_ID: 1225804
display name: L-Pro

L-Leucine
type: SmallMolecule
entity reference: CHEBI_15603
data source: Provenance1
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref14659
xref: UnificationXref14658
cellular location: GO_0031905
comment: Reactome DB_ID: 1225809
display name: L-Leu

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: CHEBI_18019
data source: Provenance1
name: Lysine acid
name: L-Lysine
xref: UnificationXref14660
xref: UnificationXref14661
cellular location: GO_0031905
comment: Reactome DB_ID: 1225806
display name: L-Lys

http://identifiers.org/pubmed/12851482
type: PublicationXref
id: 12851482
author: Poon, RY
author: Woo, RA
db: Pubmed
title: Cyclin-dependent kinases and S phase control in mammalian cells
source: Cell Cycle 2:316-24
year: 2003

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI_15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref14654
xref: UnificationXref14655
cellular location: GO_0031905
comment: Reactome DB_ID: 1225823
display name: L-His

L-Isoleucine
type: SmallMolecule
entity reference: L-Isoleucine [ChEBI:17191]
data source: Provenance1
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref14656
xref: UnificationXref14657
cellular location: GO_0031905
comment: Reactome DB_ID: 1225818
display name: L-Ile

L-Glutamine
type: SmallMolecule
entity reference: CHEBI_18050
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref14652
xref: UnificationXref14653
cellular location: GO_0031905
comment: Reactome DB_ID: 1225810
display name: L-Gln

G beta:gamma signalling through PI3Kgamma
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction51
pathway component: BiochemicalReaction1404
evidence: Evidence2246
xref: UnificationXref14345
xref: UnificationXref14346
pathway order: PathwayStep99
pathway order: PathwayStep2156
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12288
type: UnificationXref
id: REACT_221300
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221300.2

UnificationXref12289
type: UnificationXref
id: 379770
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379770

UnificationXref12286
type: UnificationXref
id: 5586144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586144

UnificationXref12287
type: UnificationXref
id: 5586146
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586146

UnificationXref12284
type: UnificationXref
id: 379753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379753

UnificationXref12285
type: UnificationXref
id: REACT_15807
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15807.1

UnificationXref12282
type: UnificationXref
id: 379740
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379740

UnificationXref12283
type: UnificationXref
id: REACT_15900
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15900.1

UnificationXref12292
type: UnificationXref
id: REACT_15734
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15734.1

UnificationXref12291
type: UnificationXref
id: 379781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379781

UnificationXref12290
type: UnificationXref
id: REACT_16111
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16111.1

UnificationXref12294
type: UnificationXref
id: 5586141
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586141

UnificationXref12293
type: UnificationXref
id: 5586140
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586140

UnificationXref12296
type: UnificationXref
id: REACT_223572
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223572.2

UnificationXref12295
type: UnificationXref
id: 5586143
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586143

UnificationXref12298
type: UnificationXref
id: 379752
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379752

UnificationXref12297
type: UnificationXref
id: 379695
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379695

UnificationXref12299
type: UnificationXref
id: REACT_17378
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17378.1

http://identifiers.org/pubmed/9153422
type: PublicationXref
id: 9153422
author: Batelier, G
author: Soulié, S
author: Melki, R
author: Williams RC, Jr
db: Pubmed
title: Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
source: Biochemistry 36:5817-26
year: 1997

SequenceSite4295
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4294
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite4293
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4292
type: SequenceSite
position status: EQUAL
sequence position: 199

SequenceSite4291
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4290
type: SequenceSite
position status: EQUAL
sequence position: 199

SequenceSite4299
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4298
type: SequenceSite
position status: EQUAL
sequence position: 214

SequenceSite4297
type: SequenceSite
position status: EQUAL
sequence position: 53

SequenceSite4296
type: SequenceSite
position status: EQUAL
sequence position: 198

ChEBI:33447 phospho sugar
type: SmallMoleculeReference
name: Sugar phosphate
name: phospho sugar
xref: UnificationXref10709

http://identifiers.org/pubmed/9811831
type: PublicationXref
id: 9811831
author: Tonks, NK
author: Batty, IH
author: Pass, I
author: Hemmings, BA
author: Myers, MP
author: van der Kaay, J
author: Downes, CP
author: Wigler, Michael H
author: Stolarov, JP
db: Pubmed
title: The lipid phosphatase activity of PTEN is critical for its tumor supressor function
source: Proc Natl Acad Sci U S A 95:13513-8
year: 1998

SequenceSite4280
type: SequenceSite
position status: EQUAL
sequence position: 166

http://identifiers.org/pubmed/11015561
type: PublicationXref
id: 11015561
author: Abcouwer, SF
author: Meguid, RA
author: Qian, M
author: Souba, WW
author: Elgadi, KM
db: Pubmed
title: Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing
source: Physiol Genomics 1:51-62
year: 1999

SequenceSite4282
type: SequenceSite
position status: EQUAL
sequence position: 256

SequenceSite4281
type: SequenceSite
position status: EQUAL
sequence position: 63

SequenceSite4284
type: SequenceSite
position status: EQUAL
sequence position: 256

SequenceSite4283
type: SequenceSite
position status: EQUAL
sequence position: 63

SequenceSite4286
type: SequenceSite
position status: EQUAL
sequence position: 214

SequenceSite4285
type: SequenceSite
position status: EQUAL
sequence position: 53

SequenceSite4288
type: SequenceSite
position status: EQUAL
sequence position: 105

SequenceSite4287
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4289
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite4273
type: SequenceSite
position status: EQUAL
sequence position: 261

SequenceSite4272
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4271
type: SequenceSite
position status: EQUAL
sequence position: 261

SequenceSite4270
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4277
type: SequenceSite
position status: EQUAL
sequence position: 166

SequenceSite4276
type: SequenceSite
position status: EQUAL
sequence position: 60

SequenceSite4275
type: SequenceSite
position status: EQUAL
sequence position: 522

SequenceSite4274
type: SequenceSite
position status: EQUAL
sequence position: 44

SequenceSite4279
type: SequenceSite
position status: EQUAL
sequence position: 60

SequenceSite4278
type: SequenceSite
position status: EQUAL
sequence position: 90

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191346
data source: Provenance1
name: PIK4CB
name: DDB0191346
xref: UnificationXref5376
feature: FragmentFeature1045
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589890
display name: PI4KB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232329
data source: Provenance1
name: PIK4CB
name: DDB0232329
xref: UnificationXref5375
feature: FragmentFeature1044
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589886
display name: PI4KB

Homologues of PI4KB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5377
cellular location: Golgi membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589891

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191101
data source: Provenance1
name: DDB0191101
name: Arf1
xref: UnificationXref5373
feature: FragmentFeature1043
cellular location: Golgi membrane
comment: Reactome DB_ID: 5584944
display name: ARF1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233948
data source: Provenance1
name: KIAA0851
name: DDB0233948
xref: UnificationXref5384
feature: FragmentFeature1047
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589983
display name: SACM1L

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219574
data source: Provenance1
name: KIAA0851
name: DDB0219574
xref: UnificationXref5385
feature: FragmentFeature1048
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589987
display name: SACM1L

Homologues of SACM1L
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5386
cellular location: Golgi membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305236
data source: Provenance1
name: KIAA0851
name: DDB0305236
xref: UnificationXref5383
feature: FragmentFeature1046
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589979
display name: SACM1L

DDB0219939
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219939
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PIK3C3
name: PI3K class III Catalytic subunit
xref: UnificationXref5393
feature: FragmentFeature1049
cellular location: GO_0005829
comment: Reactome DB_ID: 5583730
display name: VPS34

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0216334
data source: Provenance1
name: DDB0216334
name: PI3K class III regulatory subunit
xref: UnificationXref5396
feature: FragmentFeature1050
cellular location: GO_0005829
comment: Reactome DB_ID: 5583734
display name: PIK3R4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235158
data source: Provenance1
name: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
name: DDB0235158
name: P3C2A_HUMAN
xref: UnificationXref5401
feature: FragmentFeature1051
cellular location: GO_0005829
comment: Reactome DB_ID: 5589907
display name: PIK3C2A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref5414
feature: FragmentFeature1053
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589899
display name: TRX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234209
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: KIAA0981
name: DDB0234209
xref: UnificationXref5412
feature: FragmentFeature1052
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589900
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235158
data source: Provenance1
name: DDB0235158
xref: UnificationXref5425
feature: FragmentFeature1055
cellular location: GO_0005829
comment: Reactome DB_ID: 5589910
display name: PIK3C2G

DDB0205575
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref5416
feature: FragmentFeature1054
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589898
display name: FIG4

TPTE2-like proteins
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5431
cellular location: Golgi membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5590029

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191093
data source: Provenance1
name: TPTE2
name: DDB0191093
xref: UnificationXref5430
feature: FragmentFeature1056
cellular location: Golgi membrane
comment: Reactome DB_ID: 5590028
display name: TPIP

Homologues of PIP5K1A
type: Protein
data source: Provenance1
member physical entity: DDB0185056
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5446
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589786

DDB0185056
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185056
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PI51A_HUMAN
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
xref: UnificationXref5443
feature: FragmentFeature1057
cellular location: GO_0005829
comment: Reactome DB_ID: 5589781
display name: PIP5K1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234214
data source: Provenance1
name: PI51A_HUMAN
name: DDB0234214
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
xref: UnificationXref5445
feature: FragmentFeature1058
cellular location: GO_0005829
comment: Reactome DB_ID: 5589785
display name: PIP5K1A

DDB0185056
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185056
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PIP5K1gamma
xref: UnificationXref5451
feature: FragmentFeature1062
cellular location: GO_0005829
comment: Reactome DB_ID: 5589791
display name: PIP5K1C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234214
data source: Provenance1
name: PIP5K1gamma
name: DDB0234214
xref: UnificationXref5450
feature: FragmentFeature1061
cellular location: GO_0005829
comment: Reactome DB_ID: 5589790
display name: PIP5K1C

Homologues of PIP5K1C
type: Protein
data source: Provenance1
member physical entity: DDB0185056
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5452
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589792

DDB0185056
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185056
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
name: PIP5K1B
name: PI51B_HUMAN
xref: UnificationXref5448
feature: FragmentFeature1060
cellular location: GO_0005829
comment: Reactome DB_ID: 5589788
display name: STM7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234214
data source: Provenance1
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
name: DDB0234214
name: PIP5K1B
name: PI51B_HUMAN
xref: UnificationXref5447
feature: FragmentFeature1059
cellular location: GO_0005829
comment: Reactome DB_ID: 5589787
display name: STM7

Homologues of PIP5K1B
type: Protein
data source: Provenance1
member physical entity: DDB0185056
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5449
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589789

http://identifiers.org/pubmed/8672512
type: PublicationXref
id: 8672512
author: Horiuchi, S
author: Sano, H
author: Yoshida, M
author: Jinnouchi, Y
author: Higashi, T
author: Ikeda, K
author: Araki, T
author: Ueda, S
db: Pubmed
title: N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction
source: Biochemistry 35:8075-83
year: 1996

INPP5(2)
type: Protein
data source: Provenance1
member physical entity: Protein961
member physical entity: Protein962
xref: UnificationXref5464
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589921

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0235158
data source: Provenance1
name: DDB0235158
xref: UnificationXref5467
feature: FragmentFeature1064
cellular location: GO_0005829
comment: Reactome DB_ID: 5589955
display name: PIK3C2B

SYNJ
type: Protein
data source: Provenance1
member physical entity: Protein963
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5457
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589865

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185180
data source: Provenance1
name: DDB0185180
name: KIAA0348
xref: UnificationXref5456
feature: FragmentFeature1063
cellular location: GO_0005829
comment: Reactome DB_ID: 5589864
display name: SYNJ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190271
data source: Provenance1
name: MTM1
name: DDB0190271
xref: UnificationXref5492
feature: FragmentFeature1068
cellular location: GO_0005829
comment: Reactome DB_ID: 5589817
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190143
data source: Provenance1
name: MTM1
name: DDB0190143
xref: UnificationXref5490
feature: FragmentFeature1067
cellular location: GO_0005829
comment: Reactome DB_ID: 5589813
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0204242
data source: Provenance1
name: MTM1
name: DDB0204242
xref: UnificationXref5496
feature: FragmentFeature1070
cellular location: GO_0005829
comment: Reactome DB_ID: 5589825
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238869
data source: Provenance1
name: MTM1
name: DDB0238869
xref: UnificationXref5494
feature: FragmentFeature1069
cellular location: GO_0005829
comment: Reactome DB_ID: 5589821
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0234212
data source: Provenance1
name: PIP5K2A
name: DDB0234212
name: PIP4K2A
xref: UnificationXref5478
feature: FragmentFeature1065
cellular location: GO_0005829
comment: Reactome DB_ID: 5589799
display name: PIP5K2

Homologues of MTM1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5499
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589830

DDB0252852
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0252852
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PIP5K2B
xref: UnificationXref5481
feature: FragmentFeature1066
cellular location: GO_0005829
comment: Reactome DB_ID: 5589804
display name: PIP4K2B

UnificationXref12206
type: UnificationXref
id: 5585903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585903

UnificationXref12207
type: UnificationXref
id: 5585905
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585905

UnificationXref12208
type: UnificationXref
id: REACT_205809
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205809.2

UnificationXref12209
type: UnificationXref
id: CHEBI:29182
db: ChEBI

UnificationXref12202
type: UnificationXref
id: 379765
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379765

UnificationXref12203
type: UnificationXref
id: REACT_17447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17447.1

UnificationXref12204
type: UnificationXref
id: DDB0231245
db: UniProt

UnificationXref12205
type: UnificationXref
id: 5585902
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585902

UnificationXref12200
type: UnificationXref
id: REACT_15882
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15882.1

UnificationXref12201
type: UnificationXref
id: CHEBI:29159
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238873
data source: Provenance1
name: MTM1
name: DDB0238873
xref: UnificationXref5498
feature: FragmentFeature1071
cellular location: GO_0005829
comment: Reactome DB_ID: 5589829
display name: CG2

Homologues of MTMR1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5505
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589932

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0190143
data source: Provenance1
name: DDB0190143
xref: UnificationXref5500
feature: FragmentFeature1072
cellular location: GO_0005829
comment: Reactome DB_ID: 5589927
display name: MTMR1

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1067
pathway component: BiochemicalReaction1068
pathway component: BiochemicalReaction1065
pathway component: BiochemicalReaction1066
pathway component: BiochemicalReaction1063
pathway component: BiochemicalReaction1064
evidence: Evidence1635
xref: UnificationXref10653
xref: UnificationXref10654
xref: RelationshipXref1441
pathway order: PathwayStep1602
pathway order: PathwayStep1597
pathway order: PathwayStep1601
pathway order: PathwayStep1600
pathway order: PathwayStep1599
pathway order: PathwayStep1598
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction551
evidence: Evidence836
xref: RelationshipXref763
xref: UnificationXref5833
xref: UnificationXref5834
pathway order: PathwayStep815
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref12212
type: UnificationXref
id: CHEBI:29161
db: ChEBI

UnificationXref12211
type: UnificationXref
id: REACT_23144
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23144.1

UnificationXref12210
type: UnificationXref
id: 379743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379743

UnificationXref12216
type: UnificationXref
id: 5585909
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585909

UnificationXref12215
type: UnificationXref
id: DDB0231243
db: UniProt

UnificationXref12214
type: UnificationXref
id: REACT_18116
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18116.1

UnificationXref12213
type: UnificationXref
id: 379785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379785

UnificationXref12219
type: UnificationXref
id: REACT_201957
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201957.2

UnificationXref12218
type: UnificationXref
id: 5585912
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585912

UnificationXref12217
type: UnificationXref
id: 5585910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585910

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0266713
data source: Provenance1
name: DDB0266713
name: Cholinephosphotransferase 1
name: Diacylglycerol cholinephosphotransferase 1
name: CHPT1
xref: UnificationXref5163
feature: FragmentFeature1020
cellular location: Golgi membrane
comment: Reactome DB_ID: 5589442
display name: CPT1

Phosphatidylserine synthase 1
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233122
data source: Provenance1
name: DDB0233122
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5202
feature: FragmentFeature1021
cellular location: GO_0005789
comment: Reactome DB_ID: 5589538
display name: PTDSS1

LPCAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5178
cellular location: GO_0005789
comment: Reactome DB_ID: 5589330
comment: Converted from EntitySet in Reactome

LPSAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Lysophospholipid acyltransferase 1
xref: UnificationXref5213
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589354

DDB0233122
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233122
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphatidylserine synthase 2
name: PTDSS2
xref: UnificationXref5205
feature: FragmentFeature1022
cellular location: GO_0005789
comment: Reactome DB_ID: 5589468
display name: PSS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0218645
data source: Provenance1
name: PI synthase
name: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
name: PtdIns synthase
name: Phosphatidylinositol synthase
name: DDB0218645
xref: UnificationXref5235
feature: FragmentFeature1024
cellular location: GO_0005789
comment: Reactome DB_ID: 5589451
display name: CDIPT

UnificationXref12221
type: UnificationXref
id: 379793
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379793

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233125
data source: Provenance1
name: Phosphatidate cytidylyltransferase 1
name: CDP-DAG synthase 1
name: CDS1
name: DDB0233125
xref: UnificationXref5227
feature: FragmentFeature1023
cellular location: GO_0005789
comment: Reactome DB_ID: 5589490
display name: CDS

UnificationXref12220
type: UnificationXref
id: CHEBI:29183
db: ChEBI

Homologues of PLD3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5261
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589519

UnificationXref12223
type: UnificationXref
id: CHEBI:29164
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0304755
data source: Provenance1
name: Lysophosphatidylinositol acyltransferase
name: Lysophospholipid acyltransferase 7
name: MBOAT7
name: LPLAT 7
name: Membrane-bound O-acyltransferase domain-containing protein 7
name: DDB0304755
xref: UnificationXref5246
feature: FragmentFeature1025
cellular location: GO_0005789
comment: Reactome DB_ID: 5589342
display name: LPIAT

UnificationXref12222
type: UnificationXref
id: REACT_15833
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15833.1

UnificationXref12225
type: UnificationXref
id: REACT_15717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15717.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:DDB0231505
data source: Provenance1
name: Phospholipase D3
name: DDB0231505
xref: UnificationXref5259
feature: FragmentFeature1026
cellular location: GO_0005789
comment: Reactome DB_ID: 5589514
display name: PLD3

UnificationXref12224
type: UnificationXref
id: 379790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379790

UnificationXref12227
type: UnificationXref
id: 5585944
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585944

UnificationXref12226
type: UnificationXref
id: DDB0231269
db: UniProt

UnificationXref12229
type: UnificationXref
id: REACT_213216
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213216.2

UnificationXref12228
type: UnificationXref
id: 5585946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585946

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220113
data source: Provenance1
name: Phospholipase D3
name: DDB0220113
xref: UnificationXref5260
feature: FragmentFeature1027
cellular location: GO_0005789
comment: Reactome DB_ID: 5589518
display name: PLD3

Homologues of PLD4
type: Protein
data source: Provenance1
member physical entity: Phospholipase D4
xref: UnificationXref5264
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589522

Phosphorylation of the APC/C
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction948
evidence: Evidence1425
xref: RelationshipXref1317
xref: UnificationXref9404
xref: UnificationXref9403
pathway order: PathwayStep1400
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/12438653
type: PublicationXref
id: 12438653
author: Rosenblatt, DS
author: Wilson, Aaron
author: Leclerc, Daniel
author: Doré, Carole
author: Wu, Xuchu
author: Hudson, Thomas
author: Dobson, C Melissa
author: Gravel, RA
author: Wai, Timothy
db: Pubmed
title: Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
source: Proc. Natl. Acad. Sci. U.S.A. 99:15554-9
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238066
data source: Provenance1
name: DDB0238066
name: PLA2G6
xref: UnificationXref5305
feature: FragmentFeature1034
cellular location: GO_0005743
comment: Reactome DB_ID: 5589372
display name: iPLA2

UnificationXref12234
type: UnificationXref
id: 379730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379730

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238065
data source: Provenance1
name: DDB0238065
name: PLA2G6
xref: UnificationXref5304
feature: FragmentFeature1033
cellular location: GO_0005743
comment: Reactome DB_ID: 5589368
display name: iPLA2

UnificationXref12233
type: UnificationXref
id: REACT_15767
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15767.1

Homologues of PLA2G6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: DDB0238064
xref: UnificationXref5307
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589377

UnificationXref12232
type: UnificationXref
id: 379729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379729

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0185057
data source: Provenance1
name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 ecNumber3.1.3.27/ecNumber
name: DDB0185057
xref: UnificationXref5291
feature: FragmentFeature1032
cellular location: GO_0005743
comment: Reactome DB_ID: 5589551
display name: PTPMT1

UnificationXref12231
type: UnificationXref
id: REACT_252544
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252544.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237934
data source: Provenance1
name: Phosphatidylglycerophosphate synthase 1
name: DDB0237934
name: PGP synthase 1
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
xref: UnificationXref5285
feature: FragmentFeature1031
cellular location: GO_0005743
comment: Reactome DB_ID: 5589410
display name: PGS1

UnificationXref12230
type: UnificationXref
id: 5592359
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592359

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233125
data source: Provenance1
name: Phosphatidate cytidylyltransferase 2
name: CDP-DAG synthase 2
name: DDB0233125
xref: UnificationXref5276
feature: FragmentFeature1030
cellular location: GO_0005743
comment: Reactome DB_ID: 5589526
display name: CDS2

Phospholipase D4
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0220113
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Choline phosphatase 4
name: DDB0220113
xref: UnificationXref5263
feature: FragmentFeature1029
cellular location: GO_0005789
comment: Reactome DB_ID: 5589521
display name: PLD4

Phospholipase D4
type: Protein
entity reference: UniProt:DDB0231505
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Choline phosphatase 4
name: DDB0231505
xref: UnificationXref5262
feature: FragmentFeature1028
cellular location: GO_0005789
comment: Reactome DB_ID: 5589520
display name: PLD4

UnificationXref12239
type: UnificationXref
id: 379727
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379727

UnificationXref12238
type: UnificationXref
id: REACT_221193
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221193.2

UnificationXref12237
type: UnificationXref
id: 5586067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586067

UnificationXref12236
type: UnificationXref
id: 5586065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586065

UnificationXref12235
type: UnificationXref
id: REACT_15557
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15557.1

DDB0238064
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238064
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PLA2G6
xref: UnificationXref5306
feature: FragmentFeature1035
cellular location: GO_0005743
comment: Reactome DB_ID: 5589376
display name: iPLA2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0237792
data source: Provenance1
name: TAZ_HUMAN
name: DDB0237792
name: Tafazzin
xref: UnificationXref5315
feature: FragmentFeature1036
cellular location: GO_0005743
comment: Reactome DB_ID: 5589383
display name: TAZ

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0238120
data source: Provenance1
name: PIK4CA
name: PI4KA
name: DDB0238120
xref: UnificationXref5345
feature: FragmentFeature1037
cellular location: GO_0005829
comment: Reactome DB_ID: 5589855
display name: PI4K

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0232329
data source: Provenance1
name: PIK4CB
name: DDB0232329
xref: UnificationXref5366
feature: FragmentFeature1041
cellular location: GO_0005829
comment: Reactome DB_ID: 5590008
display name: PI4KB

UnificationXref12243
type: UnificationXref
id: DDB0231324
db: UniProt

http://identifiers.org/pubmed/12671646
type: PublicationXref
id: 12671646
author: Chao, MV
db: Pubmed
title: Neurotrophins and their receptors: a convergence point for many signalling pathways
source: Nat Rev Neurosci 4:299-309
year: 2003

Homologues of PI4KB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5369
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5590010

UnificationXref12242
type: UnificationXref
id: REACT_16098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16098.1

UnificationXref12245
type: UnificationXref
id: 5586112
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586112

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0191346
data source: Provenance1
name: PIK4CB
name: DDB0191346
xref: UnificationXref5368
feature: FragmentFeature1042
cellular location: GO_0005829
comment: Reactome DB_ID: 5590009
display name: PI4KB

UnificationXref12244
type: UnificationXref
id: 5586110
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586110

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0305236
data source: Provenance1
name: KIAA0851
name: DDB0305236
xref: UnificationXref5349
feature: FragmentFeature1038
cellular location: GO_0005789
comment: Reactome DB_ID: 5589991
display name: SACM1L

Homologues of SACM1L
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5354
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5589994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0219574
data source: Provenance1
name: KIAA0851
name: DDB0219574
xref: UnificationXref5353
feature: FragmentFeature1040
cellular location: GO_0005789
comment: Reactome DB_ID: 5589993
display name: SACM1L

UnificationXref12241
type: UnificationXref
id: 379708
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379708

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: http://purl.uniprot.org/uniprot/DDB0233948
data source: Provenance1
name: KIAA0851
name: DDB0233948
xref: UnificationXref5351
feature: FragmentFeature1039
cellular location: GO_0005789
comment: Reactome DB_ID: 5589992
display name: SACM1L

UnificationXref12240
type: UnificationXref
id: REACT_17365
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17365.1

http://identifiers.org/pubmed/18760361
type: PublicationXref
id: 18760361
author: Maness, PF
author: Schmid, RS
db: Pubmed
title: L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
source: Curr Opin Neurobiol 18:245-50
year: 2008

UnificationXref12247
type: UnificationXref
id: 379703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379703

UnificationXref12246
type: UnificationXref
id: REACT_211783
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211783.2

UnificationXref12249
type: UnificationXref
id: 379699
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379699

UnificationXref12248
type: UnificationXref
id: REACT_15752
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15752.2

UnificationXref12347
type: UnificationXref
id: 379775
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379775

UnificationXref12348
type: UnificationXref
id: REACT_22591
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22591.1

UnificationXref12345
type: UnificationXref
id: 5586094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586094

UnificationXref12346
type: UnificationXref
id: REACT_203185
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203185.2

UnificationXref12349
type: UnificationXref
id: 379745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379745

UnificationXref12340
type: UnificationXref
id: REACT_17466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17466.1

(R)-3-Hydroxybutanoate
type: SmallMoleculeReference
name: (R)-3-Hydroxybutanoic acid
name: (R)-3-Hydroxybutanoate [ChEBI:17066]
name: (R)-3-Hydroxybutyric acid
xref: UnificationXref4300

UnificationXref12343
type: UnificationXref
id: DDB0231330
db: UniProt

UnificationXref12344
type: UnificationXref
id: 5586092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586092

UnificationXref12341
type: UnificationXref
id: 379789
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379789

UnificationXref12342
type: UnificationXref
id: REACT_16119
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16119.1

UnificationXref12334
type: UnificationXref
id: DDB0231296
db: UniProt

UnificationXref12335
type: UnificationXref
id: 5586043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586043

UnificationXref12336
type: UnificationXref
id: 5586045
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586045

UnificationXref12337
type: UnificationXref
id: REACT_205178
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205178.2

UnificationXref12338
type: UnificationXref
id: 379701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379701

UnificationXref12339
type: UnificationXref
id: 379760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379760

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

2-aminosuccinic acid
type: SmallMoleculeReference
name: L-Aspartate
name: L-Aspartate [ChEBI:17053]
name: L-Aspartic acid
xref: UnificationXref1875

UnificationXref12330
type: UnificationXref
id: REACT_16039
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16039.1

UnificationXref12331
type: UnificationXref
id: 379705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379705

UnificationXref12332
type: UnificationXref
id: 379780
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379780

UnificationXref12333
type: UnificationXref
id: REACT_15919
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15919.1

UnificationXref12369
type: UnificationXref
id: REACT_15748
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15748.1

UnificationXref12367
type: UnificationXref
id: REACT_15829
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15829.2

UnificationXref12368
type: UnificationXref
id: 379791
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379791

UnificationXref12365
type: UnificationXref
id: REACT_212632
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212632.2

UnificationXref12366
type: UnificationXref
id: 379706
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379706

http://identifiers.org/pubmed/8562305
type: PublicationXref
id: 8562305
author: Degerman, E
author: Belfrage, P
author: Manganiello, VC
author: Taira, M
db: Pubmed
title: Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
source: Cell Signal 7:445-55
year: 1995

UnificationXref12363
type: UnificationXref
id: 5586137
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586137

UnificationXref12364
type: UnificationXref
id: 5586139
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586139

UnificationXref12361
type: UnificationXref
id: DDB0231306
db: UniProt

UnificationXref12362
type: UnificationXref
id: 5586136
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586136

UnificationXref12360
type: UnificationXref
id: REACT_15932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15932.1

UnificationXref12356
type: UnificationXref
id: REACT_15595
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15595.2

http://identifiers.org/pubmed/21078816
type: PublicationXref
id: 21078816
author: Mooi, Wolter J
author: Michaloglou, Chrysiis
author: Peeper, Daniel S
author: Kuilman, Thomas
db: Pubmed
title: The essence of senescence
source: Genes Dev. 24:2463-79
year: 2010

UnificationXref12357
type: UnificationXref
id: 379761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379761

UnificationXref12358
type: UnificationXref
id: REACT_15998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15998.1

UnificationXref12359
type: UnificationXref
id: 379777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379777

UnificationXref12352
type: UnificationXref
id: 5586071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586071

UnificationXref12353
type: UnificationXref
id: 5586073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586073

UnificationXref12354
type: UnificationXref
id: REACT_227342
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_227342.2

UnificationXref12355
type: UnificationXref
id: 379732
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379732

UnificationXref12350
type: UnificationXref
id: REACT_23357
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23357.1

UnificationXref12351
type: UnificationXref
id: DDB0231314
db: UniProt

L-alpha-Aminoadipic acid
type: SmallMoleculeReference
name: L-2-Aminoadipate
name: L-2-Aminoadipate [ChEBI:17082]
name: L-2-Aminoadipic acid
name: L-alpha-Aminoadipate
xref: UnificationXref7396

http://identifiers.org/pubmed/11606068
type: PublicationXref
id: 11606068
author: Lorkowski, S
author: Rust, S
author: Engel, T
author: Berger, G
author: Assmann, G
author: Cullen, P
author: Lueken, A
author: Schlüter, B
db: Pubmed
title: The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages
source: Biochem Biophys Res Commun 288:483-8
year: 2001

UnificationXref12300
type: UnificationXref
id: 379764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379764

UnificationXref12304
type: UnificationXref
id: REACT_213657
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213657.2

UnificationXref12303
type: UnificationXref
id: 5586132
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586132

UnificationXref12302
type: UnificationXref
id: 5586130
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586130

UnificationXref12301
type: UnificationXref
id: REACT_15671
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15671.1

UnificationXref12308
type: UnificationXref
id: REACT_16053
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16053.1

UnificationXref12307
type: UnificationXref
id: 379769
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379769

UnificationXref12306
type: UnificationXref
id: REACT_15750
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15750.1

UnificationXref12305
type: UnificationXref
id: 379750
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379750

UnificationXref12309
type: UnificationXref
id: DDB0231256
db: UniProt

http://identifiers.org/pubmed/24695224
type: PublicationXref
id: 24695224
author: Sanjiv, Kumar
author: Gustafsson, Robert
author: Kalderén, Christina
author: Gustavsson, Anna-Lena
author: Svensson, Richard
author: Loseva, Olga
author: Olofsson, Roger
author: Pham, Therese
author: Granelli, Ingrid
author: Ström, Cecilia E
author: Baranczewski, Pawel
author: Wiita, Elisee
author: Koolmeister, Tobias
author: Häggblad, Maria
author: Wallner, Olov A
author: Berntsson, Ronnie P-A
author: Höglund, Andreas
author: Hagenkort, Anna
author: Schultz, Niklas
author: Johansson, Lars
author: Gad, Helge
author: Johansson, Fredrik
author: Bräutigam, Lars
author: Svensson, Linda M
author: Göktürk, Camilla
author: Martens, Ulf
author: Jemth, Ann-Sofie
author: Axelsson, Hanna
author: Vikingsson, Svante
author: Artursson, Per
author: Hammarström, Lars G J
author: Saleh, Aljona
author: Homan, Evert J
author: Lundbäck, Thomas
author: Henriksson, Martin
author: Lundgren, Bo
author: Vallin, Karl S A
author: Helleday, Thomas
author: Stenmark, Pål
author: Puigvert, Jordi Carreras
author: Jacques-Cordonnier, Marie-Caroline
author: Strömberg, Kia
author: Lundin, Cecilia
author: Jeppsson, Fredrik
author: Desroses, Matthieu
author: Almlöf, Ingrid
author: Altun, Mikael
author: Jensen, Annika Jenmalm
author: Djureinovic, Tatjana
author: Evers, Bastiaan
author: Einarsdottir, Berglind Osk
author: Scobie, Martin
author: Gaugaz, Fabienne Z
author: Jacques, Sylvain A
author: Nilsson, Jonas A
author: Berglund, Ulrika Warpman
author: Eshtad, Saeed
db: Pubmed
title: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
source: Nature 508:215-21
year: 2014

http://identifiers.org/pubmed/24695225
type: PublicationXref
id: 24695225
author: Bennett, Keiryn L
author: Sanjiv, Kumar
author: Radic, Branka
author: Helleday, Thomas
author: Loizou, Joanna I
author: Stukalov, Alexey
author: Knapp, Stefan
author: Elkins, JM
author: Göktürk, Camilla
author: Salah, Eidarus
author: Pham, Therese
author: Jemth, Ann-Sofie
author: Colinge, Jacques
author: Strömberg, Kia
author: Berglund, Ulrika Warpman
author: Huber, Kilian V M
author: Superti-Furga, Giulio
author: Gridling, Manuela
db: Pubmed
title: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
source: Nature 508:222-7
year: 2014

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

http://identifiers.org/pubmed/10548110
type: PublicationXref
id: 10548110
author: Lukas, J
author: Kramer, E
author: Peters, JM
author: Lindeneg, C
author: Santoni-Rugiu, E
author: Sorensen, CS
author: Lukas, C
db: Pubmed
title: Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
source: Nature 401:815-8
year: 1999

UnificationXref12322
type: UnificationXref
id: REACT_17942
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17942.1

UnificationXref12321
type: UnificationXref
id: 379747
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379747

UnificationXref12320
type: UnificationXref
id: REACT_203050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203050.2

UnificationXref12329
type: UnificationXref
id: 379741
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379741

UnificationXref12328
type: UnificationXref
id: REACT_225927
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_225927.2

UnificationXref12327
type: UnificationXref
id: 5586129
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586129

UnificationXref12326
type: UnificationXref
id: 5586127
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586127

UnificationXref12325
type: UnificationXref
id: 5586126
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586126

UnificationXref12324
type: UnificationXref
id: REACT_16107
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16107.1

UnificationXref12323
type: UnificationXref
id: 379795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379795

http://identifiers.org/pubmed/11435397
type: PublicationXref
id: 11435397
author: Allikmets, R
author: Dean, M
author: Rzhetsky, A
db: Pubmed
title: The human ATP-binding cassette (ABC) transporter superfamily
source: Genome Res 11:1156-66
year: 2001

http://identifiers.org/pubmed/183598
type: PublicationXref
id: 183598
author: Clark, P
author: Edwards, YH
author: Harris, H
db: Pubmed
title: Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals.
source: Ann Hum Genet 40:67-77
year: 1976

UnificationXref12311
type: UnificationXref
id: 5586064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586064

UnificationXref12310
type: UnificationXref
id: 5586062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586062

UnificationXref12317
type: UnificationXref
id: DDB0231251
db: UniProt

UnificationXref12316
type: UnificationXref
id: REACT_18097
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18097.1

UnificationXref12319
type: UnificationXref
id: 5586085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586085

UnificationXref12318
type: UnificationXref
id: 5586083
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586083

UnificationXref12313
type: UnificationXref
id: 379788
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379788

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, Henri-Gery
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

UnificationXref12312
type: UnificationXref
id: REACT_214229
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_214229.2

UnificationXref12315
type: UnificationXref
id: 379773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379773

UnificationXref12314
type: UnificationXref
id: REACT_17073
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17073.1

http://identifiers.org/pubmed/18651836
type: PublicationXref
id: 18651836
author: Agius, L
db: Pubmed
title: Glucokinase and molecular aspects of liver glycogen metabolism
source: Biochem. J. 414:1-18
year: 2008

http://identifiers.org/pubmed/9736715
type: PublicationXref
id: 9736715
author: Dedhar, S
author: Rue, L
author: Gray, V
author: Delcommenne, M
author: Woodgett, J
author: Tan, C
db: Pubmed
title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
source: Proc Natl Acad Sci U S A 95:11211-6
year: 1998

GDP-L-fucose
type: SmallMoleculeReference
name: GDP-L-fucose [ChEBI:5221]
xref: UnificationXref10177

UnificationXref12390
type: UnificationXref
id: DDB0231247
db: UniProt

UnificationXref12391
type: UnificationXref
id: 5586055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586055

(S)-4,5-Dihydroorotate
type: SmallMoleculeReference
name: Dihydro-L-orotic acid
name: (S)-Dihydroorotate
name: L-Dihydroorotic acid
name: (S)-Dihydroorotate [ChEBI:17025]
name: L-Dihydroorotate
xref: UnificationXref6740

UnificationXref12382
type: UnificationXref
id: 5586106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586106

UnificationXref12381
type: UnificationXref
id: 5586104
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586104

UnificationXref12384
type: UnificationXref
id: 379756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379756

Progesterone
type: SmallMoleculeReference
name: 4-Pregnene-3,20-dione
name: Progesterone [ChEBI:8453]
xref: UnificationXref4925

UnificationXref12383
type: UnificationXref
id: REACT_209367
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209367.2

UnificationXref12386
type: UnificationXref
id: 379710
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379710

UnificationXref12385
type: UnificationXref
id: REACT_18191
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18191.1

UnificationXref12388
type: UnificationXref
id: 379755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379755

UnificationXref12387
type: UnificationXref
id: REACT_15744
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15744.2

UnificationXref12389
type: UnificationXref
id: REACT_15651
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15651.1

http://identifiers.org/pubmed/11015619
type: PublicationXref
id: 11015619
author: Rusnak, F
author: Mertz, P
db: Pubmed
title: Calcineurin: form and function
source: Physiol. Rev. 80:1483-521
year: 2000

http://identifiers.org/pubmed/11015615
type: PublicationXref
id: 11015615
author: Pentyala, SN
author: Rebecchi, MJ
db: Pubmed
title: Structure, function, and control of phosphoinositide-specific phospholipase C
source: Physiol Rev 80:1291-335
year: 2000

UnificationXref12380
type: UnificationXref
id: DDB0231246
db: UniProt

http://identifiers.org/pubmed/6788990
type: PublicationXref
id: 6788990
author: Kamijo, K
author: Kobayashi, S
author: Oguchi, K
author: Uesato, T
db: Pubmed
title: Studies on beta-phenylethylamine deamination by human placental monoamine oxidase
source: Jpn J Pharmacol 31:7-14
year: 1981

UnificationXref12373
type: UnificationXref
id: 5586088
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586088

UnificationXref12372
type: UnificationXref
id: 5586086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586086

UnificationXref12371
type: UnificationXref
id: REACT_17148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17148.1

Thymidylic acid
type: SmallMoleculeReference
name: Deoxythymidylic acid
name: dTMP
name: Thymidylate
name: 5'-Thymidylic acid
name: Thymidine 5'-phosphate
name: Deoxythymidine 5'-phosphate
name: dTMP [ChEBI:17013]
name: Thymidine monophosphate
xref: UnificationXref6791

UnificationXref12370
type: UnificationXref
id: 379779
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379779

UnificationXref12377
type: UnificationXref
id: 379709
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379709

UnificationXref12376
type: UnificationXref
id: REACT_15653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15653.1

UnificationXref12375
type: UnificationXref
id: 379774
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379774

UnificationXref12374
type: UnificationXref
id: REACT_212924
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212924.2

UnificationXref12379
type: UnificationXref
id: REACT_15822
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15822.1

UnificationXref12378
type: UnificationXref
id: 379759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379759

Displacement of DNA glycosylase by APE1
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1076
pathway component: BiochemicalReaction1077
pathway component: BiochemicalReaction1078
pathway component: BiochemicalReaction1075
evidence: Evidence1649
xref: UnificationXref10698
xref: UnificationXref10697
pathway order: PathwayStep1616
pathway order: PathwayStep1615
pathway order: PathwayStep1614
pathway order: PathwayStep1613
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/10053006
type: PublicationXref
id: 10053006
author: Wasmuth, JJ
author: Thompson, LM
author: Tavormina, PL
author: Jabs, EW
author: Bellus, GA
author: Donoghue, DJ
author: Szabo, J
author: Webster, MK
author: Jiang, W
author: Wilcox, WR
author: Bamshad, MJ
author: Francomano, CA
author: Fraley, AE
author: McIntosh, I
db: Pubmed
title: A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
source: Am J Hum Genet 64:722-31
year: 1999

http://identifiers.org/pubmed/19252894
type: PublicationXref
id: 19252894
author: Brandt, N
author: Mackintosh, C
author: Treebak, JT
author: Hardie, DG
author: Pilegaard, H
author: Wojtaszewski, JF
author: Chen, S
author: Kiens, B
author: Zierath, JR
author: Frøsig, C
author: Richter, EA
author: Maarbjerg, SJ
author: Pehmøller, C
db: Pubmed
title: Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
source: Diabetologia 52:891-900
year: 2009

http://identifiers.org/pubmed/11257506
type: PublicationXref
id: 11257506
author: Gandour, RD
author: van der Leij, FR
author: Ramsay, RR
db: Pubmed
title: Molecular enzymology of carnitine transfer and transport
source: Biochim Biophys Acta 1546:21-43
year: 2001

UnificationXref12399
type: UnificationXref
id: DDB0304686
db: UniProt

UnificationXref12398
type: UnificationXref
id: REACT_15572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15572.1

UnificationXref12397
type: UnificationXref
id: 379782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379782

UnificationXref12396
type: UnificationXref
id: REACT_15875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15875.1

UnificationXref12395
type: UnificationXref
id: 379735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379735

UnificationXref12394
type: UnificationXref
id: REACT_217260
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_217260.2

UnificationXref12393
type: UnificationXref
id: 5586058
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586058

http://identifiers.org/pubmed/11711427
type: PublicationXref
id: 11711427
author: Wang, X
db: Pubmed
title: The expanding role of mitochondria in apoptosis.
source: Genes Dev 15:2922-33
year: 2001

UnificationXref12392
type: UnificationXref
id: 5586056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5586056

Chromatin modifying enzymes
type: Pathway
data source: Provenance1
pathway component: REACT 231143.1
evidence: Evidence1296
xref: UnificationXref8842
xref: UnificationXref8843
pathway order: PathwayStep1273
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/15047616
type: PublicationXref
id: 15047616
author: Nolan, C
author: Roduit, R
author: Delghingaro-Augusto, V
author: Przybykowski, E
author: Barbeau, A
author: Poitout, V
author: Massé, F
author: Ruderman, N
author: Rhodes, C
author: Massie, B
author: Morin, J
author: Moore, P
author: Prentki, M
author: Alarcon, C
db: Pubmed
title: A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
source: Diabetes 53:1007-19
year: 2004

http://identifiers.org/pubmed/16650285
type: PublicationXref
id: 16650285
author: Gorelick, DA
author: Agre, P
author: Tsunenari, T
author: Nielsen, S
author: Praetorius, J
db: Pubmed
title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
source: BMC Biochem 7:14
year: 2006

http://identifiers.org/pubmed/24717514
type: PublicationXref
id: 24717514
author: Wang, Ya-chin
author: Alhonen, Leena
author: Gong, Fengying
author: Rodgers, Joseph T
author: Banks, Alexander S
author: Bhanot, Sanjay
author: Pulinilkunnil, Thomas C
author: Zhang, Lin
author: Cen, Yana
author: Peroni, Odile D
author: Kraus, Daniel
author: Sauve, Anthony A
author: Kong, Dong
author: Kahn, Barbara B
author: Yang, Qin
author: Asara, John M
author: Puigserver, Pere
author: Pirinen, Eija
author: Monia, Brett P
db: Pubmed
title: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
source: Nature 508:258-62
year: 2014

http://identifiers.org/pubmed/8855281
type: PublicationXref
id: 8855281
author: Lu, M
author: Verdijk, MA
author: Smith, BL
author: Agre, P
author: Jung, JS
author: Lee, MD
author: Deen, PM
author: Rijss, JP
author: Merkx, G
db: Pubmed
title: The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain
source: Proc Natl Acad Sci U S A 93:10908-12
year: 1996

UnificationXref6210
type: UnificationXref
id: 1222424
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222424

UnificationXref6211
type: UnificationXref
id: REACT_111446
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111446.2

UnificationXref6212
type: UnificationXref
id: CHEBI:15375
db: ChEBI

UnificationXref6213
type: UnificationXref
id: 1497857
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1497857

UnificationXref6214
type: UnificationXref
id: REACT_111511
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111511.1

UnificationXref6215
type: UnificationXref
id: 5589600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589600

UnificationXref6216
type: UnificationXref
id: 5589603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589603

UnificationXref6217
type: UnificationXref
id: REACT_245130
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245130.1

UnificationXref6218
type: UnificationXref
id: 5585171
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585171

UnificationXref6219
type: UnificationXref
id: DDB0234150
db: UniProt

Pristanal
type: SmallMoleculeReference
name: ChEBI:49189 Pristanal
xref: UnificationXref4439

UnificationXref6221
type: UnificationXref
id: 5585239
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585239

UnificationXref6222
type: UnificationXref
id: 5585241
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585241

UnificationXref6220
type: UnificationXref
id: 5585238
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585238

UnificationXref6225
type: UnificationXref
id: 5585173
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585173

UnificationXref6226
type: UnificationXref
id: 5585174
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585174

UnificationXref6223
type: UnificationXref
id: REACT_242030
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242030.1

UnificationXref6224
type: UnificationXref
id: 5585172
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585172

UnificationXref6229
type: UnificationXref
id: REACT_244391
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244391.1

UnificationXref6227
type: UnificationXref
id: REACT_229486
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229486.1

UnificationXref6228
type: UnificationXref
id: 5592788
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592788

http://identifiers.org/pubmed/15231747
type: PublicationXref
id: 15231747
author: Lehner, B
author: Sanderson, CM
db: Pubmed
title: A protein interaction framework for human mRNA degradation
source: Genome Res 14:1315-23
year: 2004

http://identifiers.org/pubmed/5441548
type: PublicationXref
id: 5441548
author: Salen, G
author: Grundy, SM
author: Ahrens EH, Jr
db: Pubmed
title: Metabolism of beta-sitosterol in man
source: J Clin Invest 49:952-67
year: 1970

http://identifiers.org/pubmed/9050246
type: PublicationXref
id: 9050246
author: Nikinmaa, M
db: Pubmed
title: Oxygen and carbon dioxide transport in vertebrate erythrocytes: an evolutionary change in the role of membrane transport
source: J Exp Biol 200:369-80
year: 1997

UnificationXref6200
type: UnificationXref
id: 5585164
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585164

UnificationXref6207
type: UnificationXref
id: 5585169
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585169

UnificationXref6208
type: UnificationXref
id: REACT_243644
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243644.1

UnificationXref6205
type: UnificationXref
id: 5589596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589596

UnificationXref6206
type: UnificationXref
id: REACT_245626
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245626.1

UnificationXref6203
type: UnificationXref
id: REACT_252036
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252036.1

UnificationXref6204
type: UnificationXref
id: 5585167
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585167

Keratan sulfate/keratin metabolism
type: Pathway
data source: Provenance1
pathway component: Keratan sulfate degradation
pathway component: REACT 219478.2
evidence: Evidence244
xref: UnificationXref2021
xref: UnificationXref2022
xref: RelationshipXref149
pathway order: PathwayStep226
pathway order: PathwayStep223
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref6201
type: UnificationXref
id: 5585165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585165

UnificationXref6202
type: UnificationXref
id: 5585166
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585166

UnificationXref6209
type: UnificationXref
id: CHEBI:18421
db: ChEBI

http://identifiers.org/pubmed/15167709
type: PublicationXref
id: 15167709
author: Blanchard, RL
author: Buck, J
author: Freimuth, RR
author: Coughtrie, MW
author: Weinshilboum, RM
db: Pubmed
title: A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
source: Pharmacogenetics 14:199-211
year: 2004

UnificationXref6259
type: UnificationXref
id: REACT_207435
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207435.2

UnificationXref6258
type: UnificationXref
id: 5589324
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589324

UnificationXref6257
type: UnificationXref
id: 5589310
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589310

UnificationXref6256
type: UnificationXref
id: 5589309
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589309

UnificationXref6251
type: UnificationXref
id: 5589304
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589304

UnificationXref6250
type: UnificationXref
id: REACT_192869
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_192869.3

http://identifiers.org/pubmed/10224048
type: PublicationXref
id: 10224048
author: Guo, S
author: York, JD
author: Lemrow, SM
author: Stolz, LE
db: Pubmed
title: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
source: J Biol Chem 274:12990-5
year: 1999

UnificationXref6255
type: UnificationXref
id: 5589322
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589322

UnificationXref6254
type: UnificationXref
id: 5589321
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589321

UnificationXref6253
type: UnificationXref
id: DDB0232952
db: UniProt

UnificationXref6252
type: UnificationXref
id: 5589303
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589303

UnificationXref6268
type: UnificationXref
id: 5589604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589604

UnificationXref6267
type: UnificationXref
id: DDB0191275
db: UniProt

UnificationXref6269
type: UnificationXref
id: 5589605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589605

UnificationXref6260
type: UnificationXref
id: CHEBI:17804
db: ChEBI

UnificationXref6262
type: UnificationXref
id: REACT_111417
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111417.1

UnificationXref6261
type: UnificationXref
id: 1474179
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1474179

UnificationXref6264
type: UnificationXref
id: REACT_111639
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111639.1

UnificationXref6263
type: UnificationXref
id: 1475054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1475054

UnificationXref6266
type: UnificationXref
id: REACT_192846
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_192846.3

UnificationXref6265
type: UnificationXref
id: 5589312
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589312

http://identifiers.org/pubmed/17392515
type: PublicationXref
id: 17392515
author: Doller, A
author: Müller, R
author: Eberhardt, W
author: Huwiler, A
author: Radeke, HH
author: Pfeilschifter, J
db: Pubmed
title: Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
source: Mol Biol Cell 18:2137-48
year: 2007

UnificationXref6239
type: UnificationXref
id: REACT_251010
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251010.1

UnificationXref6238
type: UnificationXref
id: 5585245
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585245

UnificationXref6237
type: UnificationXref
id: 5585244
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585244

UnificationXref6236
type: UnificationXref
id: 5585242
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585242

UnificationXref6235
type: UnificationXref
id: 5585243
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585243

UnificationXref6234
type: UnificationXref
id: REACT_247257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247257.1

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

UnificationXref6233
type: UnificationXref
id: 5585231
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585231

UnificationXref6232
type: UnificationXref
id: 5585230
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585230

UnificationXref6231
type: UnificationXref
id: 5585229
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5585229

UnificationXref6230
type: UnificationXref
id: DDB0302416
db: UniProt

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

UnificationXref6249
type: UnificationXref
id: 5589302
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589302

UnificationXref6246
type: UnificationXref
id: 5589298
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589298

UnificationXref6245
type: UnificationXref
id: DDB0191399
db: UniProt

UnificationXref6248
type: UnificationXref
id: 5589300
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589300

UnificationXref6247
type: UnificationXref
id: 5589299
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589299

UnificationXref6242
type: UnificationXref
id: CHEBI:18372
db: ChEBI

UnificationXref6241
type: UnificationXref
id: REACT_244773
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244773.1

UnificationXref6244
type: UnificationXref
id: REACT_111890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111890.1

UnificationXref6243
type: UnificationXref
id: 1474124
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1474124

UnificationXref6240
type: UnificationXref
id: 5592794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592794

Transport and synthesis of PAPS
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction124
pathway component: BiochemicalReaction123
pathway component: BiochemicalReaction122
evidence: Evidence238
xref: UnificationXref1969
xref: RelationshipXref142
xref: UnificationXref1970
pathway order: PathwayStep220
pathway order: PathwayStep218
pathway order: PathwayStep219
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/9748295
type: PublicationXref
id: 9748295
author: Brown, MS
author: Guryev, O
author: Goldstein, JL
author: Pai, JT
db: Pubmed
title: Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
source: J Biol Chem 273:26138-48
year: 1998

UnificationXref6294
type: UnificationXref
id: DDB0230192
db: UniProt

UnificationXref6295
type: UnificationXref
id: 5579749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579749

UnificationXref6292
type: UnificationXref
id: 113557
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113557

UnificationXref6293
type: UnificationXref
id: REACT_4060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4060.2

UnificationXref6298
type: UnificationXref
id: 5579744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579744

UnificationXref6299
type: UnificationXref
id: 5579745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579745

UnificationXref6296
type: UnificationXref
id: DDB0215387
db: UniProt

UnificationXref6297
type: UnificationXref
id: MOD:00127
db: MOD

PI3K events in ERBB2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 210939.2
evidence: Evidence2213
xref: UnificationXref14053
xref: UnificationXref14052
pathway order: PathwayStep183
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

RAF activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction25
evidence: Evidence43
xref: UnificationXref310
xref: UnificationXref309
pathway order: PathwayStep38
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

UnificationXref6280
type: UnificationXref
id: REACT_111258
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111258.1

UnificationXref6276
type: UnificationXref
id: 5589601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589601

UnificationXref6277
type: UnificationXref
id: REACT_256110
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256110.1

http://identifiers.org/pubmed/20869317
type: PublicationXref
id: 20869317
author: Shastri, N
author: Blanchard, N
db: Pubmed
title: Topological journey of parasite-derived antigens for presentation by MHC class I molecules
source: Trends Immunol 31:414-21
year: 2010

UnificationXref6274
type: UnificationXref
id: 5589320
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589320

UnificationXref6275
type: UnificationXref
id: REACT_192852
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_192852.3

UnificationXref6272
type: UnificationXref
id: 5589606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589606

UnificationXref6273
type: UnificationXref
id: REACT_219804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219804.2

UnificationXref6270
type: UnificationXref
id: 5589317
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589317

UnificationXref6271
type: UnificationXref
id: 5589318
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589318

UnificationXref6278
type: UnificationXref
id: CHEBI:16095
db: ChEBI

UnificationXref6279
type: UnificationXref
id: 1497811
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1497811

http://identifiers.org/pubmed/12716889
type: PublicationXref
id: 12716889
author: Jigami, Y
author: Suzuki, M
author: Okubo, R
author: Kikuchi, N
author: Saigo, K
author: Ueda, R
author: Goto, S
author: Toyoda, H
author: Suda, T
author: Narimatsu, H
author: Kamiyama, S
author: Chiba, Y
author: Nishihara, S
author: Watanabe, M
db: Pubmed
title: Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter
source: J Biol Chem 278:25958-63
year: 2003

UnificationXref6291
type: UnificationXref
id: REACT_206387
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206387.2

UnificationXref6290
type: UnificationXref
id: 5592790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592790

UnificationXref6285
type: UnificationXref
id: REACT_195060
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_195060.3

UnificationXref6286
type: UnificationXref
id: 5592992
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592992

UnificationXref6287
type: UnificationXref
id: REACT_212091
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212091.2

UnificationXref6288
type: UnificationXref
id: 5592789
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592789

UnificationXref6281
type: UnificationXref
id: 5589607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589607

UnificationXref6282
type: UnificationXref
id: REACT_194783
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_194783.3

UnificationXref6283
type: UnificationXref
id: 5589597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589597

UnificationXref6284
type: UnificationXref
id: 5589599
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5589599

UnificationXref6289
type: UnificationXref
id: REACT_209392
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209392.2

UnificationXref12486
type: UnificationXref
id: 5581356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581356

UnificationXref12487
type: UnificationXref
id: DDB0191511
db: UniProt

UnificationXref12484
type: UnificationXref
id: 5581355
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581355

UnificationXref12485
type: UnificationXref
id: 5581354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581354

UnificationXref12482
type: UnificationXref
id: 5582762
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582762

UnificationXref12483
type: UnificationXref
id: 5581352
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581352

UnificationXref12480
type: UnificationXref
id: 5580686
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5580686

UnificationXref12481
type: UnificationXref
id: DDB0191343
db: UniProt

UnificationXref12488
type: UnificationXref
id: 5588356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588356

UnificationXref12489
type: UnificationXref
id: 5588357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588357

http://identifiers.org/pubmed/19273840
type: PublicationXref
id: 19273840
author: Chen, LM
author: Pelletier, MF
author: Musa-Aziz, R
author: Boron, WF
db: Pubmed
title: Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
source: Proc Natl Acad Sci U S A 106:5406-11
year: 2009

UnificationXref12490
type: UnificationXref
id: DDB0204566
db: UniProt

L-Asparagine
type: SmallMoleculeReference
name: L-Asparagine [ChEBI:17196]
name: 2-Aminosuccinamic acid
xref: UnificationXref7138

UnificationXref12473
type: UnificationXref
id: 5588376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588376

UnificationXref12474
type: UnificationXref
id: DDB0214990
db: UniProt

UnificationXref12475
type: UnificationXref
id: 5582757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582757

UnificationXref12476
type: UnificationXref
id: 5582758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5582758

UnificationXref12470
type: UnificationXref
id: 5588367
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588367

UnificationXref12471
type: UnificationXref
id: DDB0185525
db: UniProt

UnificationXref12472
type: UnificationXref
id: 5588371
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588371

UnificationXref12477
type: UnificationXref
id: CHEBI:17843
db: ChEBI

UnificationXref12478
type: UnificationXref
id: 141679
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141679

UnificationXref12479
type: UnificationXref
id: REACT_2376
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2376.2

http://identifiers.org/pubmed/6696436
type: PublicationXref
id: 6696436
author: Freemont, PS
author: Fothergill, LA
author: Dunbar, B
db: Pubmed
title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments
source: Arch Biochem Biophys 228:342-52
year: 1984

UnificationXref12460
type: UnificationXref
id: REACT_174628
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_174628.3

UnificationXref12461
type: UnificationXref
id: 5592897
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592897

UnificationXref12464
type: UnificationXref
id: REACT_211012
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211012.2

UnificationXref12465
type: UnificationXref
id: DDB0233746
db: UniProt

UnificationXref12462
type: UnificationXref
id: REACT_202940
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202940.2

UnificationXref12463
type: UnificationXref
id: 5592898
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592898

UnificationXref12468
type: UnificationXref
id: 5588375
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588375

UnificationXref12469
type: UnificationXref
id: DDB0217022
db: UniProt

UnificationXref12466
type: UnificationXref
id: 5588337
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588337

UnificationXref12467
type: UnificationXref
id: DDB0229297
db: UniProt

L-Isoleucine [ChEBI:17191]
type: SmallMoleculeReference
name: L-Isoleucine
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref7203

UnificationXref12450
type: UnificationXref
id: 5587149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587149

UnificationXref12451
type: UnificationXref
id: 5587157
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587157

UnificationXref12452
type: UnificationXref
id: 5587158
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587158

UnificationXref12453
type: UnificationXref
id: REACT_246155
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246155.1

UnificationXref12454
type: UnificationXref
id: 429875
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429875

UnificationXref12455
type: UnificationXref
id: REACT_20726
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20726.1

UnificationXref12456
type: UnificationXref
id: 5587150
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587150

UnificationXref12457
type: UnificationXref
id: DDB0237528
db: UniProt

UnificationXref12458
type: UnificationXref
id: 5587154
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587154

UnificationXref12459
type: UnificationXref
id: 5587156
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587156

http://identifiers.org/pubmed/12450384
type: PublicationXref
id: 12450384
author: Zhang, Y
author: Desharnais, J
author: Beardsley, GP
author: Wilson, IA
author: Greasley, SE
author: Boger, DL
db: Pubmed
title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
source: Biochemistry 41:14206-14215
year: 2002

Triacylglycerol biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction359
pathway component: BiochemicalReaction358
pathway component: REACT 212387.2
pathway component: BiochemicalReaction360
pathway component: BiochemicalReaction362
pathway component: BiochemicalReaction357
pathway component: BiochemicalReaction361
evidence: Evidence572
xref: UnificationXref4137
xref: UnificationXref4138
xref: RelationshipXref490
pathway order: PathwayStep548
pathway order: PathwayStep549
pathway order: PathwayStep550
pathway order: PathwayStep552
pathway order: PathwayStep551
pathway order: PathwayStep546
pathway order: PathwayStep547
display name: Triglyceride Biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/12721290
type: PublicationXref
id: 12721290
author: Maness, PF
author: Richter, M
author: Midkiff, BR
author: Buhusi, M
author: Gates, AM
author: Schachner, M
db: Pubmed
title: Close homolog of L1 is an enhancer of integrin-mediated cell migration
source: J Biol Chem 278:25024-31
year: 2003

UnificationXref12449
type: UnificationXref
id: 5587143
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587143

UnificationXref12448
type: UnificationXref
id: DDB0233198
db: UniProt

UnificationXref12447
type: UnificationXref
id: 5587135
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587135

UnificationXref12446
type: UnificationXref
id: DDB0233378
db: UniProt

UnificationXref12445
type: UnificationXref
id: 5587131
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587131

UnificationXref12444
type: UnificationXref
id: DDB0233377
db: UniProt

UnificationXref12443
type: UnificationXref
id: 5587144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587144

UnificationXref12442
type: UnificationXref
id: 5587148
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587148

UnificationXref12441
type: UnificationXref
id: DDB0233196
db: UniProt

UnificationXref12440
type: UnificationXref
id: 5587139
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587139

Catalysis1095
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1476
control type: ACTIVATION
xref: RelationshipXref1814
xref: RelationshipXref6
controller: Protein3237

Catalysis1094
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1475
control type: ACTIVATION
xref: RelationshipXref1813
xref: RelationshipXref820
controller: Protein3236

Catalysis1093
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1474
control type: ACTIVATION
xref: RelationshipXref1811
xref: RelationshipXref1810
controller: Homologues of PLA2G6

Catalysis1092
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1473
control type: ACTIVATION
xref: RelationshipXref200
xref: RelationshipXref1809
controller: Protein3234

UniProt:DDB0215235
type: ProteinReference
xref: UnificationXref13075
organism: http://identifiers.org/taxonomy/44689

Catalysis1097
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1480
control type: ACTIVATION
xref: RelationshipXref1817
xref: RelationshipXref46
controller: Protein3117

Catalysis1096
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1477
control type: ACTIVATION
xref: RelationshipXref1814
xref: RelationshipXref6
controller: Protein3237

Catalysis1091
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1472
control type: ACTIVATION
xref: RelationshipXref610
xref: RelationshipXref1808
controller: PhysicalEntity267

Catalysis1090
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1468
control type: ACTIVATION
xref: RelationshipXref1740
xref: RelationshipXref67

http://identifiers.org/pubmed/19303758
type: PublicationXref
id: 19303758
author: Hemmings, BA
author: Bozulic, L
db: Pubmed
title: PIKKing on PKB: regulation of PKB activity by phosphorylation
source: Curr Opin Cell Biol 21:256-61
year: 2009

UnificationXref12438
type: UnificationXref
id: 5587127
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587127

UnificationXref12437
type: UnificationXref
id: DDB0233402
db: UniProt

UnificationXref12439
type: UnificationXref
id: DDB0233383
db: UniProt

UnificationXref12434
type: UnificationXref
id: REACT_242182
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242182.1

UnificationXref12433
type: UnificationXref
id: 5587202
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587202

UnificationXref12436
type: UnificationXref
id: REACT_204770
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204770.2

UnificationXref12435
type: UnificationXref
id: 5592901
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5592901

UnificationXref12430
type: UnificationXref
id: DDB0168296
db: UniProt

UnificationXref12432
type: UnificationXref
id: 5587200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587200

UnificationXref12431
type: UnificationXref
id: 5587191
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587191

http://identifiers.org/pubmed/15809071
type: PublicationXref
id: 15809071
author: Ishibashi, K
author: Uchida, S
author: Ko, SB
author: Sasaki, S
author: Kuwahara, M
author: Rai, T
author: Itoh, T
db: Pubmed
title: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
source: Biochem Biophys Res Commun 330:832-8
year: 2005

UnificationXref12425
type: UnificationXref
id: DDB0202891
db: UniProt

UnificationXref12424
type: UnificationXref
id: 5587166
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587166

UnificationXref12423
type: UnificationXref
id: DDB0183823
db: UniProt

UnificationXref12422
type: UnificationXref
id: 5587178
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587178

UnificationXref12429
type: UnificationXref
id: 5587183
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587183

UnificationXref12428
type: UnificationXref
id: 5587170
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587170

UnificationXref12427
type: UnificationXref
id: DDB0206469
db: UniProt

UnificationXref12426
type: UnificationXref
id: 5587182
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587182

UnificationXref12421
type: UnificationXref
id: DDB0185805
db: UniProt

UnificationXref12420
type: UnificationXref
id: 5587162
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587162

Catalysis1078
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1449
control type: ACTIVATION
xref: RelationshipXref50
xref: RelationshipXref49
controller: Complex38

Catalysis1079
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1450
control type: ACTIVATION
xref: RelationshipXref1776
xref: RelationshipXref167
controller: PhysicalEntity247

Catalysis1077
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1448
control type: ACTIVATION
xref: RelationshipXref1774
xref: RelationshipXref1775
controller: Protein3121

Catalysis1076
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1447
control type: ACTIVATION
xref: RelationshipXref1773
xref: RelationshipXref46
controller: Protein3114

Catalysis1075
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1446
control type: ACTIVATION
xref: RelationshipXref1772
xref: RelationshipXref67
controller: Complex1236

Catalysis1074
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1444
control type: ACTIVATION
xref: RelationshipXref1771
xref: RelationshipXref200
controller: Complex1235

Catalysis1073
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1442
control type: ACTIVATION
xref: RelationshipXref116
xref: RelationshipXref115
controller: Complex95

Catalysis1072
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1441
control type: ACTIVATION
xref: RelationshipXref115
xref: RelationshipXref1768
controller: Protein961

Catalysis1071
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1440
control type: ACTIVATION
xref: RelationshipXref25
xref: RelationshipXref1767
controller: Complex1232

http://identifiers.org/pubmed/11684289
type: PublicationXref
id: 11684289
author: Villadangos, JA
db: Pubmed
title: Presentation of antigens by MHC class II molecules: getting the most out of them
source: Mol Immunol 38:329-46
year: 2001

Catalysis1070
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1437
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref1766
controller: Protein3100

UnificationXref12412
type: UnificationXref
id: 5587199
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587199

UnificationXref12411
type: UnificationXref
id: DDB0186485
db: UniProt

UnificationXref12414
type: UnificationXref
id: 5587187
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587187

UnificationXref12413
type: UnificationXref
id: DDB0234145
db: UniProt

UnificationXref12416
type: UnificationXref
id: 5587195
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587195

UnificationXref12415
type: UnificationXref
id: DDB0183814
db: UniProt

UnificationXref12418
type: UnificationXref
id: 5587174
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5587174

UnificationXref12417
type: UnificationXref
id: DDB0184528
db: UniProt

Catalysis1089
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1466
control type: ACTIVATION
xref: RelationshipXref1807
xref: RelationshipXref1806
controller: Complex1246

UnificationXref12410
type: UnificationXref
id: REACT_20913
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20913.1

Catalysis1086
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1457
control type: ACTIVATION
xref: RelationshipXref1788
xref: RelationshipXref6
controller: Protein3162

Catalysis1085
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1456
control type: ACTIVATION
xref: RelationshipXref1786
xref: RelationshipXref1781
controller: Protein3140

Catalysis1088
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1461
control type: ACTIVATION
xref: RelationshipXref1802
xref: RelationshipXref1801
controller: Protein45

Catalysis1087
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1458
control type: ACTIVATION
xref: RelationshipXref1789
xref: RelationshipXref1335
controller: PhysicalEntity259

Catalysis1082
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1453
control type: ACTIVATION
xref: RelationshipXref50
xref: RelationshipXref49
controller: Complex38

Catalysis1081
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1452
control type: ACTIVATION
xref: RelationshipXref1251
xref: RelationshipXref1779
controller: Complex1240

Catalysis1084
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1455
control type: ACTIVATION
xref: RelationshipXref50
xref: RelationshipXref49
controller: Complex38

Catalysis1083
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1454
control type: ACTIVATION
xref: RelationshipXref1782
xref: RelationshipXref1781
controller: Protein3138

UnificationXref12419
type: UnificationXref
id: DDB0216807
db: UniProt

Catalysis1080
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1451
control type: ACTIVATION
xref: RelationshipXref1778
xref: RelationshipXref49
controller: PhysicalEntity250

G-protein beta:gamma signalling
type: Pathway
data source: Provenance1
pathway component: G beta:gamma signalling through PI3Kgamma
evidence: Evidence2247
xref: UnificationXref14347
xref: UnificationXref14348
pathway order: PathwayStep2208
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Catalysis1050
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1407
control type: ACTIVATION
xref: RelationshipXref1740
xref: RelationshipXref67

Catalysis1051
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1408
control type: ACTIVATION
xref: RelationshipXref781
xref: RelationshipXref1741
controller: Protein2925

Catalysis1052
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1409
control type: ACTIVATION
xref: RelationshipXref1743
xref: RelationshipXref46
controller: Protein2928

Catalysis1053
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1410
control type: ACTIVATION
xref: RelationshipXref1745
xref: RelationshipXref1744
controller: PhysicalEntity234

Catalysis1054
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1411
control type: ACTIVATION
xref: RelationshipXref1746
xref: RelationshipXref1335
controller: PhysicalEntity237

Catalysis1055
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1414
control type: ACTIVATION
xref: RelationshipXref1748
xref: RelationshipXref810
controller: Complex82

Catalysis1057
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1416
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref1751
controller: Complex370

Catalysis1056
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1415
control type: ACTIVATION
xref: RelationshipXref1749
xref: RelationshipXref1750
controller: PhysicalEntity241

Catalysis1059
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1418
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref1753
controller: Complex791

Catalysis1058
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1417
control type: ACTIVATION
xref: RelationshipXref67
xref: RelationshipXref1752
controller: Complex1196

http://identifiers.org/pubmed/17567461
type: PublicationXref
id: 17567461
author: Lemasters, JJ
db: Pubmed
title: Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism
source: J Gastroenterol Hepatol 22:S31-7
year: 2007

http://identifiers.org/pubmed/12184727
type: PublicationXref
id: 12184727
author: Tseng, LF
author: Sora, I
author: Narita, M
author: Mizoguchi, H
author: Suzuki, T
db: Pubmed
title: Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin
source: Jpn J Pharmacol 89:229-34
year: 2002

3-Hydroxy-4-trimethylammoniobutanoate
type: SmallMoleculeReference
name: Carnitine [ChEBI:17126]
name: gamma-Trimethyl-hydroxybutyrobetaine
name: Carnitine
xref: UnificationXref4139

Catalysis1061
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1422
control type: ACTIVATION
xref: RelationshipXref1755
xref: RelationshipXref57
controller: Complex1202

Catalysis1062
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1423
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref1756
controller: PhysicalEntity11

Catalysis1060
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1420
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref1754
controller: Complex1194

Catalysis1065
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1426
control type: ACTIVATION
xref: RelationshipXref1758
xref: RelationshipXref65
controller: PhysicalEntity243

Catalysis1066
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1428
control type: ACTIVATION
xref: RelationshipXref25
xref: RelationshipXref1759
controller: Complex1214

Catalysis1063
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1424
control type: ACTIVATION
xref: RelationshipXref1745
xref: RelationshipXref1744
controller: PhysicalEntity234

Catalysis1064
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1425
control type: ACTIVATION
xref: RelationshipXref1757
xref: RelationshipXref65
controller: Complex1206

5-Phosphoribosyl 1-pyrophosphate
type: SmallMoleculeReference
name: 5-Phosphoribosyl diphosphate
name: PRPP
name: 5-phospho-alpha-D-ribose 1-diphosphate
name: 5-phospho-alpha-D-ribose 1-diphosphate [ChEBI:17111]
xref: UnificationXref2796

Catalysis1069
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1432
control type: ACTIVATION
xref: RelationshipXref65
xref: RelationshipXref1764
controller: Complex1215

Catalysis1068
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1431
control type: ACTIVATION
xref: RelationshipXref810
xref: RelationshipXref1763
controller: Complex1215

Catalysis1067
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1430
control type: ACTIVATION
xref: RelationshipXref1761
xref: RelationshipXref1760
controller: Complex82

L-Serine
type: SmallMoleculeReference
name: L-Serine [ChEBI:17115]
xref: UnificationXref3436

D-Galactose
type: SmallMoleculeReference
name: D-Galactose [ChEBI:17118]
xref: UnificationXref2383

Catalysis1030
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1374
control type: ACTIVATION
xref: RelationshipXref1712
xref: RelationshipXref1713
controller: Complex1157

Catalysis1031
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1375
control type: ACTIVATION
xref: RelationshipXref1712
xref: RelationshipXref1713
controller: Complex1157

Catalysis1032
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1376
control type: ACTIVATION
xref: RelationshipXref376
xref: RelationshipXref1714
controller: Complex1157

Catalysis1033
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1377
control type: ACTIVATION
xref: RelationshipXref376
xref: RelationshipXref1714
controller: Complex1157

Catalysis1039
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1388
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1721
controller: Protein2827

Catalysis1038
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1387
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1720
controller: Complex1173

Catalysis1035
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1380
control type: ACTIVATION
xref: RelationshipXref1716
xref: RelationshipXref6
controller: Complex1167

Catalysis1034
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1378
control type: ACTIVATION
xref: RelationshipXref376
xref: RelationshipXref1714
controller: Complex1157

Catalysis1037
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1384
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref54
controller: Complex39

Catalysis1036
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1383
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref1717
controller: Complex1170

4-Maleylacetoacetate [ChEBI:17105]
type: SmallMoleculeReference
name: 4-Maleylacetoacetic acid
name: 4-Maleylacetoacetate
xref: UnificationXref7478

Catalysis1043
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1393
control type: ACTIVATION
xref: RelationshipXref16
xref: RelationshipXref1722
controller: Protein2839

Catalysis1044
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1395
control type: ACTIVATION
xref: RelationshipXref1723
xref: RelationshipXref494
controller: Complex1177

Catalysis1041
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1390
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1721
controller: Protein2827

Catalysis1042
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1391
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1720
controller: Complex1173

Catalysis1040
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1389
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1721
controller: Protein2827

Catalysis1049
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1405
control type: ACTIVATION
xref: RelationshipXref1738
xref: RelationshipXref1739
controller: Protein2918

Catalysis1048
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1403
control type: ACTIVATION
xref: RelationshipXref1732
xref: RelationshipXref1731
controller: Complex1181

Catalysis1047
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1399
control type: ACTIVATION
xref: RelationshipXref67
xref: RelationshipXref1727
controller: PhysicalEntity234

Catalysis1046
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1398
control type: ACTIVATION
xref: RelationshipXref1399
xref: RelationshipXref97
controller: Complex785

Catalysis1045
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1397
control type: ACTIVATION
xref: RelationshipXref53
xref: RelationshipXref1725
controller: Complex1178

Zinc efflux and compartmentalization by the SLC30 family
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1014
pathway component: BiochemicalReaction1015
pathway component: BiochemicalReaction1016
pathway component: BiochemicalReaction1017
pathway component: BiochemicalReaction1018
pathway component: BiochemicalReaction1013
evidence: Evidence1536
xref: UnificationXref10137
xref: UnificationXref10136
pathway order: PathwayStep1504
pathway order: PathwayStep1503
pathway order: PathwayStep1506
pathway order: PathwayStep1505
pathway order: PathwayStep1507
pathway order: PathwayStep1502
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/3539386
type: PublicationXref
id: 3539386
author: Wood, T
db: Pubmed
title: Physiological functions of the pentose phosphate pathway
source: Cell Biochem Funct 4:241-7
year: 1986

Deoxyguanosine [ChEBI:17172]
type: SmallMoleculeReference
name: 2'-Deoxyguanosine
name: Deoxyguanosine
xref: UnificationXref6687

Catalysis1011
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1353
control type: ACTIVATION
xref: RelationshipXref1682
xref: RelationshipXref1687
controller: Protein2704

Catalysis1010
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1352
control type: ACTIVATION
xref: RelationshipXref1678
xref: RelationshipXref1686
controller: Protein2702

http://identifiers.org/pubmed/17616525
type: PublicationXref
id: 17616525
author: Grabau, EA
author: Cho, J
author: Spraggon, G
author: Jones, DH
author: Shears, Stephen B
author: Qian, X
author: Lesley, SA
author: Stiles, AR
author: Chamberlain, PP
db: Pubmed
title: Integration of inositol phosphate signaling pathways via human ITPK1
source: J Biol Chem 282:28117-25
year: 2007

Catalysis1012
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1354
control type: ACTIVATION
xref: RelationshipXref1689
xref: RelationshipXref1688
controller: Protein2705

Catalysis1013
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1355
control type: ACTIVATION
xref: RelationshipXref1682
xref: RelationshipXref1687
controller: Protein2704

Catalysis1014
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1356
control type: ACTIVATION
xref: RelationshipXref1691
xref: RelationshipXref1690
controller: Protein2706

Catalysis1015
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1357
control type: ACTIVATION
xref: RelationshipXref1692
xref: RelationshipXref1690
controller: Protein2707

Catalysis1016
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1358
control type: ACTIVATION
xref: RelationshipXref1693
xref: RelationshipXref1690
controller: Protein2708

Catalysis1017
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1359
control type: ACTIVATION
xref: RelationshipXref1696
xref: RelationshipXref1695
controller: Protein2709

Catalysis1018
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1362
control type: ACTIVATION
xref: RelationshipXref1697
xref: RelationshipXref1698
controller: Complex1147

Catalysis1019
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1363
control type: ACTIVATION
xref: RelationshipXref1700
xref: RelationshipXref1699
controller: Protein2716

Catalysis1022
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1366
control type: ACTIVATION
xref: RelationshipXref1703
xref: RelationshipXref1704
controller: PhysicalEntity233

Catalysis1021
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1365
control type: ACTIVATION
xref: RelationshipXref1703
xref: RelationshipXref1704
controller: PhysicalEntity233

Catalysis1020
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1364
control type: ACTIVATION
xref: RelationshipXref1701
xref: RelationshipXref1702
controller: Protein2719

Transcriptional regulation of white adipocyte differentiation
type: Pathway
data source: Provenance1
pathway component: TemplateReaction4
pathway component: TemplateReaction5
evidence: Evidence65
xref: UnificationXref388
xref: UnificationXref387
pathway order: PathwayStep59
pathway order: PathwayStep58
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

Catalysis1025
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1369
control type: ACTIVATION
xref: RelationshipXref1707
xref: RelationshipXref1708
controller: Complex1154

Catalysis1026
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1370
control type: ACTIVATION
xref: RelationshipXref1710
xref: RelationshipXref1709
controller: Protein2753

Catalysis1023
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1367
control type: ACTIVATION
xref: RelationshipXref1703
xref: RelationshipXref1704
controller: PhysicalEntity233

Catalysis1024
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1368
control type: ACTIVATION
xref: RelationshipXref1706
xref: RelationshipXref1705
controller: Protein2740

Catalysis1029
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1373
control type: ACTIVATION
xref: RelationshipXref1712
xref: RelationshipXref1713
controller: Complex1157

Catalysis1027
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1371
control type: ACTIVATION
xref: RelationshipXref1710
xref: RelationshipXref1709
controller: Protein2753

Catalysis1028
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1372
control type: ACTIVATION
xref: RelationshipXref1710
xref: RelationshipXref1709
controller: Protein2753

http://identifiers.org/pubmed/10989446
type: PublicationXref
id: 10989446
author: Tamaki, N
author: Sakata, SF
author: Matsuda, K
db: Pubmed
title: Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver
source: Methods Enzymol 324:376-89
year: 2000

http://identifiers.org/pubmed/17112726
type: PublicationXref
id: 17112726
author: Hirano, Tatsuya
author: Gillespie, Peter J
author: Gandhi, Rita
db: Pubmed
title: Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase
source: Curr. Biol. 16:2406-17
year: 2006

http://identifiers.org/pubmed/18678926
type: PublicationXref
id: 18678926
author: Rajnarayanan, RV
author: Cohly, HH
author: Isokpehi, R
db: Pubmed
title: Compartmentalization of aquaporins in the human intestine
source: Int J Environ Res Public Health 5:115-9
year: 2008

1,4-Butanediamine
type: SmallMoleculeReference
name: Putrescine
name: Tetramethylenediamine
name: Putrescine [ChEBI:17148]
name: 1,4-Diaminobutane
xref: UnificationXref7612

Catalysis1000
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1342
control type: ACTIVATION
xref: RelationshipXref1665
xref: RelationshipXref1666
controller: Protein2684

UnificationXref12499
type: UnificationXref
id: 5588363
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588363

Catalysis1009
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1351
control type: ACTIVATION
xref: RelationshipXref1685
xref: RelationshipXref1684
controller: Protein2701

UnificationXref12494
type: UnificationXref
id: REACT_76257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76257.1

Catalysis1007
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1349
control type: ACTIVATION
xref: RelationshipXref1681
xref: RelationshipXref1680
controller: Protein2699

UnificationXref12493
type: UnificationXref
id: 927796
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=927796

Catalysis1008
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1350
control type: ACTIVATION
xref: RelationshipXref1682
xref: RelationshipXref1683
controller: Protein2700

UnificationXref12492
type: UnificationXref
id: 5588362
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588362

Catalysis1005
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1347
control type: ACTIVATION
xref: RelationshipXref1676
xref: RelationshipXref1677
controller: Protein2698

UnificationXref12491
type: UnificationXref
id: 5588361
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588361

Catalysis1006
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1348
control type: ACTIVATION
xref: RelationshipXref1678
xref: RelationshipXref1679
controller: Protein2699

UnificationXref12498
type: UnificationXref
id: 5588352
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5588352

Catalysis1003
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1345
control type: ACTIVATION
xref: RelationshipXref1672
xref: RelationshipXref1673
controller: Protein2694

UnificationXref12497
type: UnificationXref
id: 5581359
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581359

Catalysis1004
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1346
control type: ACTIVATION
xref: RelationshipXref1674
xref: RelationshipXref1675
controller: Protein2695

UnificationXref12496
type: UnificationXref
id: 5581357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581357

Catalysis1001
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1343
control type: ACTIVATION
xref: RelationshipXref1667
xref: RelationshipXref1668
controller: PhysicalEntity225

UnificationXref12495
type: UnificationXref
id: 5581358
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5581358

Catalysis1002
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1344
control type: ACTIVATION
xref: RelationshipXref1670
xref: RelationshipXref1669
controller: Protein2691

http://identifiers.org/pubmed/9089413
type: PublicationXref
id: 9089413
author: Miyazawa, S
author: Souri, M
author: Jiang, LL
author: Hashimoto, T
db: Pubmed
title: Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein
source: J Biochem 121:364-9
year: 1997

UniProt:DDB0219848
type: ProteinReference
xref: UnificationXref9012
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/10072072
type: PublicationXref
id: 10072072
author: Ploegh, HL
author: Haley, KJ
author: Dranoff, G
author: Shi, GP
author: Gu, L
author: Small, C
author: Chapman, HA
author: Riese, R
author: Villadangos, JA
db: Pubmed
title: Cathepsin S required for normal MHC class II peptide loading and germinal center development
source: Immunity 10:197-206
year: 1999

Latent infection of Homo sapiens with Mycobacterium tuberculosis
type: Pathway
data source: Provenance1
pathway component: REACT 227260.2
evidence: Evidence167
xref: RelationshipXref103
xref: UnificationXref1537
xref: UnificationXref1536
pathway order: PathwayStep150
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/44689

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

UnificationXref6303
type: UnificationXref
id: 5579311
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579311

UnificationXref6302
type: UnificationXref
id: 5579310
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579310

UniProt:DDB0219853
type: ProteinReference
xref: UnificationXref10822
organism: http://identifiers.org/taxonomy/44689

UnificationXref6301
type: UnificationXref
id: 5579309
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579309

UnificationXref6300
type: UnificationXref
id: DDB0216232
db: UniProt

UnificationXref6307
type: UnificationXref
id: 5579737
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579737

UnificationXref6306
type: UnificationXref
id: DDB0229442
db: UniProt

UnificationXref6305
type: UnificationXref
id: 5579733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5579733

UnificationXref6304
type: UnificationXref
id: DDB0230193
db: UniProt

UnificationXref6308
type: UnificationXref
id: 113547
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113547