UDP
type: SmallMoleculeReference
name: uridine 5'-diphosphate
name: uridine 5'-diphosphate [ChEBI:17659]
xref: UnificationXref82

UDP-D-galactose [ChEBI:18307]
type: SmallMoleculeReference
name: UDP-D-galactopyranose
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref69

SequenceSite99
type: SequenceSite
position status: EQUAL
sequence position: 742

SequenceSite98
type: SequenceSite
position status: EQUAL
sequence position: 704

SequenceSite97
type: SequenceSite
position status: EQUAL
sequence position: 602

SequenceSite91
type: SequenceSite
position status: EQUAL
sequence position: 248

SequenceSite92
type: SequenceSite
position status: EQUAL
sequence position: 289

SequenceSite90
type: SequenceSite
position status: EQUAL
sequence position: 210

SequenceSite95
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite96
type: SequenceSite
position status: EQUAL
sequence position: 488

SequenceSite93
type: SequenceSite
position status: EQUAL
sequence position: 330

SequenceSite94
type: SequenceSite
position status: EQUAL
sequence position: 368

SequenceSite87
type: SequenceSite
position status: EQUAL
sequence position: 2181

SequenceSite86
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite89
type: SequenceSite
position status: EQUAL
sequence position: 79

Mus musculus
type: BioSource
xref: UnificationXref93

SequenceSite88
type: SequenceSite
position status: EQUAL
sequence position: 40

UniProt:P97260 SCAP
type: ProteinReference
name: SCAP
xref: UnificationXref7
comment: DOMAIN Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane.SIMILARITY Belongs to the WD repeat SCAP family.SIMILARITY Contains 1 SSD (sterol-sensing) domain.SIMILARITY Contains 7 WD repeats.
organism: Cricetulus griseus

SequenceSite80
type: SequenceSite
position status: EQUAL
sequence position: 628

SequenceSite81
type: SequenceSite
position status: EQUAL
sequence position: 665

SequenceSite82
type: SequenceSite
position status: EQUAL
sequence position: 742

SequenceSite83
type: SequenceSite
position status: EQUAL
sequence position: 895

SequenceSite84
type: SequenceSite
position status: EQUAL
sequence position: 970

SequenceSite85
type: SequenceSite
position status: EQUAL
sequence position: 1130

CMP-N-acetylneuraminate [ChEBI:3278]
type: SmallMoleculeReference
name: CMP-N-acetylneuraminate
xref: UnificationXref115

SequenceSite79
type: SequenceSite
position status: EQUAL
sequence position: 590

SequenceSite77
type: SequenceSite
position status: EQUAL
sequence position: 477

SequenceSite78
type: SequenceSite
position status: EQUAL
sequence position: 515

SequenceSite75
type: SequenceSite
position status: EQUAL
sequence position: 359

SequenceSite76
type: SequenceSite
position status: EQUAL
sequence position: 439

SequenceSite74
type: SequenceSite
position status: EQUAL
sequence position: 127

SequenceSite73
type: SequenceSite
position status: EQUAL
sequence position: 86

SequenceSite72
type: SequenceSite
position status: EQUAL
sequence position: 1183

SequenceSite71
type: SequenceSite
position status: EQUAL
sequence position: 1138

SequenceSite70
type: SequenceSite
position status: EQUAL
sequence position: 1100

SequenceSite68
type: SequenceSite
position status: EQUAL
sequence position: 865

SequenceSite69
type: SequenceSite
position status: EQUAL
sequence position: 940

SequenceSite64
type: SequenceSite
position status: EQUAL
sequence position: 330

SequenceSite65
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite66
type: SequenceSite
position status: EQUAL
sequence position: 673

SequenceSite67
type: SequenceSite
position status: EQUAL
sequence position: 750

INSIG1
type: ProteinReference
name: UniProt:O15503 INSIG1
xref: UnificationXref39
comment: INDUCTION By insulin.MISCELLANEOUS Expressed at high levels when nuclear SREBP levels are high as a result of sterol deprivation.SIMILARITY Belongs to the INSIG family.
organism: Homo sapiens

SequenceSite61
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 175

SequenceSite63
type: SequenceSite
position status: EQUAL
sequence position: 292

SequenceSite62
type: SequenceSite
position status: EQUAL
sequence position: 252

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 82

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 206

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 252

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 1521

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 214

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 128

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 90

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 985

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 1023

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 1147

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 1231

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 2412

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 14

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 52

SREBP1
type: ProteinReference
name: BHLHD1
name: SREBF1
name: UniProt:P36956-3 SREBF1
xref: UnificationXref29
comment: FUNCTION Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').SUBUNIT Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.TISSUE SPECIFICITY Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.PTM At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.SIMILARITY Belongs to the SREBP family.SIMILARITY Contains 1 bHLH (basic helix-loop-helix) domain.
organism: Homo sapiens

SREBP1
type: ProteinReference
name: BHLHD1
name: SREBF1
name: UniProt:P36956-1 SREBF1
xref: UnificationXref26
comment: FUNCTION Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').SUBUNIT Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.TISSUE SPECIFICITY Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.PTM At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.SIMILARITY Belongs to the SREBP family.SIMILARITY Contains 1 bHLH (basic helix-loop-helix) domain.
organism: Homo sapiens

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 755

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 1320

Cricetulus griseus
type: BioSource
xref: UnificationXref6

endoplasmic reticulum membrane
type: CellularLocationVocabulary
xref: UnificationXref1

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 680

endoplasmic reticulum lumen
type: CellularLocationVocabulary
xref: UnificationXref158

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 492

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 454

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 605

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 567

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 104

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 1360

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 416

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 336

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1201

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 1155

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 1117

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 955

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 879

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 841

SCAP:SREBF2
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry27
component: SRBP2_HUMAN
component: SCAP tetramer
xref: UnificationXref112
xref: UnificationXref111
cellular location: Golgi membrane
display name: SCAP:SREBP2
comment: Reactome DB_ID: 1655759

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 763

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 725

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 650

SCAP tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry25
component: SCAP_CRIGR
xref: UnificationXref108
xref: UnificationXref107
cellular location: Golgi membrane
comment: Reactome DB_ID: 1655751

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 1276

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 424

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 307

http://identifiers.org/pubmed/12202038
type: PublicationXref
id: 12202038
author: Espenshade, PJ
author: Brown, MS
author: Gong, Y
author: Aebersold, R
author: Yang, T
author: Wright, ME
author: Goldstein, JL
author: Yabe, D
db: Pubmed
title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
source: Cell 110:489-500
year: 2002

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 1141

GDP-L-fucose
type: SmallMoleculeReference
name: GDP-L-fucose [ChEBI:5221]
xref: UnificationXref159

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 575

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 1147

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 225

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 1147

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 277

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 31

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 269

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 190

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

KIAA0079
type: ProteinReference
name: UniProt:P53992 SEC24C
name: SEC24C
xref: UnificationXref100
comment: SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.
organism: Homo sapiens

RelationshipXref4
type: RelationshipXref
id: 2033002
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2033002

RelationshipXref3
type: RelationshipXref
id: GO:0008373
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref2
type: RelationshipXref
id: 2029554
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2029554

RelationshipXref1
type: RelationshipXref
id: GO:0003831
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref6
type: RelationshipXref
id: 1986586
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986586

RelationshipXref5
type: RelationshipXref
id: GO:0046922
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

oxysterol
type: SmallMoleculeReference
name: oxysterols
name: oxysterol [ChEBI:53030]
xref: UnificationXref14

cholest-5-en-3beta-ol
type: SmallMoleculeReference
name: cholesterol
name: cholesterol [ChEBI:16113]
xref: UnificationXref36

Same Catalyst Activity
type: RelationshipTypeVocabulary

Golgi lumen
type: CellularLocationVocabulary
xref: UnificationXref68

Catalysis1
type: Catalysis
data source: Reactome
controlled: Galactosylation of Pre-Notch
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: B4galt1 homodimer

Catalysis2
type: Catalysis
data source: Reactome
controlled: Sialylation of Pre-Notch
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: St3gal3/4/6

Catalysis3
type: Catalysis
data source: Reactome
controlled: Fucosylation of Pre-Notch by POFUT1
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref5
controller: POFUT1

Notch3
type: ProteinReference
name: UniProt:Q61982 Notch3
xref: UnificationXref150
comment: FUNCTION Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.TISSUE SPECIFICITY Proliferating neuroepithelium.DEVELOPMENTAL STAGE CNS development.PTM Phosphorylated.PTM Hydroxylated by HIF1AN.SIMILARITY Belongs to the NOTCH family.SIMILARITY Contains 5 ANK repeats.SIMILARITY Contains 34 EGF-like domains.SIMILARITY Contains 3 LNR (Lin/Notch) repeats.
organism: Mus musculus

http://identifiers.org/pubmed/15899885
type: PublicationXref
id: 15899885
author: Sun, LP
author: Brown, MS
author: Goldstein, JL
author: Li, L
db: Pubmed
title: Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
source: J Biol Chem 280:26483-90
year: 2005

Reactome
type: Provenance
comment: http://www.reactome.org

UnificationXref91
type: UnificationXref
id: 2032355
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032355

UnificationXref92
type: UnificationXref
id: REACT_118586
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118586.2

UnificationXref90
type: UnificationXref
id: MI:0355
db: MI

UnificationXref99
type: UnificationXref
id: REACT_147932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147932.1

UnificationXref98
type: UnificationXref
id: 1655715
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655715

UnificationXref97
type: UnificationXref
id: Q9QVY3
db: UniProt

UnificationXref96
type: UnificationXref
id: REACT_148081
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148081.1

UnificationXref95
type: UnificationXref
id: 1655767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655767

UnificationXref94
type: UnificationXref
id: Q01405
db: UniProt

UnificationXref93
type: UnificationXref
id: 10090
db: NCBI Taxonomy

UnificationXref81
type: UnificationXref
id: REACT_119375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119375.1

UnificationXref80
type: UnificationXref
id: 2032300
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032300

UnificationXref82
type: UnificationXref
id: CHEBI:17659
db: ChEBI

UnificationXref83
type: UnificationXref
id: 205687
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=205687

UnificationXref84
type: UnificationXref
id: REACT_26764
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26764.1

UnificationXref85
type: UnificationXref
id: Q99PC2
db: UniProt

UnificationXref86
type: UnificationXref
id: 2023200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023200

UnificationXref87
type: UnificationXref
id: REACT_119496
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119496.1

UnificationXref88
type: UnificationXref
id: 2023202
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023202

UnificationXref89
type: UnificationXref
id: REACT_120179
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120179.1

UnificationXref70
type: UnificationXref
id: 735682
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735682

UnificationXref79
type: UnificationXref
id: REACT_120308
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120308.1

UnificationXref73
type: UnificationXref
id: REACT_119960
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119960.1

UnificationXref74
type: UnificationXref
id: 2032271
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032271

UnificationXref71
type: UnificationXref
id: REACT_23172
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23172.2

UnificationXref72
type: UnificationXref
id: 2032269
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032269

UnificationXref77
type: UnificationXref
id: REACT_119015
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119015.1

UnificationXref78
type: UnificationXref
id: 2032275
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032275

UnificationXref75
type: UnificationXref
id: REACT_119129
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119129.1

UnificationXref76
type: UnificationXref
id: 2032274
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032274

UnificationXref68
type: UnificationXref
id: GO:0005796
db: GENE ONTOLOGY

UnificationXref69
type: UnificationXref
id: CHEBI:18307
db: ChEBI

SREBP2
type: ProteinReference
name: UniProt:Q12772 SREBF2
name: BHLHD2
name: SREBF2
xref: UnificationXref3
comment: FUNCTION Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.TISSUE SPECIFICITY Ubiquitously expressed in adult and fetal tissues.SIMILARITY Belongs to the SREBP family.SIMILARITY Contains 1 bHLH (basic helix-loop-helix) domain.
organism: Homo sapiens

UnificationXref64
type: UnificationXref
id: 2032283
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032283

UnificationXref65
type: UnificationXref
id: REACT_119494
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119494.1

UnificationXref66
type: UnificationXref
id: 2032302
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032302

UnificationXref67
type: UnificationXref
id: REACT_120031
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120031.1

UnificationXref60
type: UnificationXref
id: G3HM56
db: UniProt

UnificationXref61
type: UnificationXref
id: 2032281
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032281

UnificationXref62
type: UnificationXref
id: REACT_119427
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119427.1

UnificationXref63
type: UnificationXref
id: G3HZC0
db: UniProt

UnificationXref4
type: UnificationXref
id: 1655733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655733

http://identifiers.org/pubmed/9242699
type: PublicationXref
id: 9242699
author: Brown, MS
author: Cheng, D
author: Sakai, J
author: Nohturfft, A
author: Ho, YK
author: Goldstein, JL
db: Pubmed
title: Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
source: J Biol Chem 272:20213-21
year: 1997

UnificationXref5
type: UnificationXref
id: REACT_148522
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148522.2

UnificationXref2
type: UnificationXref
id: 9606
db: NCBI Taxonomy

UnificationXref3
type: UnificationXref
id: Q12772
db: UniProt

UnificationXref1
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

UnificationXref59
type: UnificationXref
id: REACT_118874
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118874.1

http://identifiers.org/pubmed/15692013
type: PublicationXref
id: 15692013
author: Lei, L
author: Xu, A
author: Irvine, KD
author: Okajima, T
db: Pubmed
title: Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
source: Science 307:1599-603
year: 2005

I79_018123
type: ProteinReference
name: St3gal6
name: UniProt:G3I3V5 St3gal6
xref: UnificationXref137
organism: Cricetulus griseus

UnificationXref57
type: UnificationXref
id: G3HP78
db: UniProt

UnificationXref58
type: UnificationXref
id: 2032279
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032279

UnificationXref55
type: UnificationXref
id: 2032277
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032277

UnificationXref56
type: UnificationXref
id: REACT_119944
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119944.1

UnificationXref53
type: UnificationXref
id: MOD:00812
db: MOD

UnificationXref54
type: UnificationXref
id: MOD:00804
db: MOD

UnificationXref51
type: UnificationXref
id: G3I6Z6
db: UniProt

UnificationXref52
type: UnificationXref
id: MOD:00813
db: MOD

UnificationXref50
type: UnificationXref
id: GO:0000139
db: GENE ONTOLOGY

UnificationXref41
type: UnificationXref
id: REACT_148184
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148184.2

UnificationXref40
type: UnificationXref
id: 1655735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655735

UnificationXref45
type: UnificationXref
id: REACT_148574
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148574.1

UnificationXref44
type: UnificationXref
id: 1655758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655758

UnificationXref43
type: UnificationXref
id: REACT_148176
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148176.1

UnificationXref42
type: UnificationXref
id: 1655749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655749

UnificationXref8
type: UnificationXref
id: 1655763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655763

UnificationXref49
type: UnificationXref
id: REACT_147840
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147840.1

UnificationXref9
type: UnificationXref
id: REACT_148293
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148293.1

UnificationXref48
type: UnificationXref
id: 2317526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317526

UnificationXref6
type: UnificationXref
id: 10029
db: NCBI Taxonomy

UnificationXref47
type: UnificationXref
id: REACT_147975
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147975.2

UnificationXref7
type: UnificationXref
id: P97260
db: UniProt

UnificationXref46
type: UnificationXref
id: 1655727
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655727

http://identifiers.org/pubmed/12242332
type: PublicationXref
id: 12242332
author: Brown, MS
author: Goldstein, JL
author: Yabe, D
db: Pubmed
title: Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
source: Proc Natl Acad Sci U S A 99:12753-8
year: 2002

UnificationXref30
type: UnificationXref
id: 1655761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655761

UnificationXref32
type: UnificationXref
id: 1655730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655730

UnificationXref31
type: UnificationXref
id: REACT_148171
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148171.2

UnificationXref34
type: UnificationXref
id: 2326883
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2326883

UnificationXref33
type: UnificationXref
id: REACT_148091
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148091.2

UnificationXref36
type: UnificationXref
id: CHEBI:16113
db: ChEBI

UnificationXref35
type: UnificationXref
id: REACT_148327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148327.2

UnificationXref38
type: UnificationXref
id: REACT_11015
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11015.2

UnificationXref37
type: UnificationXref
id: 193384
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193384

UnificationXref39
type: UnificationXref
id: O15503
db: UniProt

UnificationXref23
type: UnificationXref
id: REACT_148178
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148178.1

UnificationXref22
type: UnificationXref
id: 2317523
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317523

UnificationXref21
type: UnificationXref
id: REACT_148058
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148058.1

UnificationXref20
type: UnificationXref
id: 2317521
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317521

UnificationXref29
type: UnificationXref
id: P36956-3
db: UniProt Isoform

UnificationXref28
type: UnificationXref
id: REACT_148375
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148375.2

UnificationXref27
type: UnificationXref
id: 1655757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655757

UnificationXref26
type: UnificationXref
id: P36956-1
db: UniProt Isoform

UnificationXref25
type: UnificationXref
id: REACT_147768
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147768.1

UnificationXref24
type: UnificationXref
id: 2317528
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317528

UnificationXref10
type: UnificationXref
id: 1655722
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655722

UnificationXref12
type: UnificationXref
id: 2317524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317524

UnificationXref11
type: UnificationXref
id: REACT_148244
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148244.1

UnificationXref18
type: UnificationXref
id: 1655736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655736

UnificationXref17
type: UnificationXref
id: Q9Y5U4
db: UniProt

UnificationXref19
type: UnificationXref
id: REACT_148247
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148247.2

UnificationXref14
type: UnificationXref
id: CHEBI:53030
db: ChEBI

UnificationXref13
type: UnificationXref
id: REACT_148265
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148265.1

UnificationXref16
type: UnificationXref
id: REACT_148138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148138.1

CMP [ChEBI:17361]
type: SmallMoleculeReference
name: Cytidine-5'-monophosphate
name: Cytidylic acid
name: CMP
xref: UnificationXref118

UnificationXref15
type: UnificationXref
id: 2317518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2317518

http://identifiers.org/pubmed/12486116
type: PublicationXref
id: 12486116
author: Shao, L
author: Moloney, DJ
author: Haltiwanger, RS
db: Pubmed
title: Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region
source: J Biol Chem 278:7775-82
year: 2003

SequenceSite100
type: SequenceSite
position status: EQUAL
sequence position: 819

SequenceSite108
type: SequenceSite
position status: EQUAL
sequence position: 734

SequenceSite107
type: SequenceSite
position status: EQUAL
sequence position: 696

SequenceSite106
type: SequenceSite
position status: EQUAL
sequence position: 594

http://identifiers.org/pubmed/15260976
type: PublicationXref
id: 15260976
author: Sun, LP
author: Brown, MS
author: Kwon, HJ
author: Goldstein, JL
author: Radhakrishnan, A
db: Pubmed
title: Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain
source: Mol Cell 15:259-68
year: 2004

SequenceSite105
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite104
type: SequenceSite
position status: EQUAL
sequence position: 480

SequenceSite103
type: SequenceSite
position status: EQUAL
sequence position: 1097

SequenceSite102
type: SequenceSite
position status: EQUAL
sequence position: 1012

SequenceSite101
type: SequenceSite
position status: EQUAL
sequence position: 942

SequenceSite109
type: SequenceSite
position status: EQUAL
sequence position: 1004

SequenceSite110
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite111
type: SequenceSite
position status: EQUAL
sequence position: 1797

SequenceSite113
type: SequenceSite
position status: EQUAL
sequence position: 2412

SequenceSite112
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite115
type: SequenceSite
position status: EQUAL
sequence position: 1521

SequenceSite114
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite117
type: SequenceSite
position status: EQUAL
sequence position: 2181

SREBP2:SCAP:CopII Coat
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry23
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry21
component stoichiometry: Stoichiometry20
component: SC23A_MOUSE
component: SCAP tetramer
component: SAR1B_CRIGR
component: S24C_HUMAN
component: SRBP2_HUMAN
xref: UnificationXref103
xref: UnificationXref104
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655768

SequenceSite116
type: SequenceSite
position status: EQUAL
sequence position: 1

B4galt1 homodimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry19
component: B4galt1
xref: UnificationXref88
xref: UnificationXref89
cellular location: Golgi membrane
comment: Reactome DB_ID: 2023202

SCAP:cholesterol
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry15
component stoichiometry: Stoichiometry16
component: SCAP tetramer
component: Cholesterol
xref: UnificationXref45
xref: UnificationXref44
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655758

SequenceSite119
type: SequenceSite
position status: EQUAL
sequence position: 1797

SREBP1A,1C,2:SCAP:cholesterol:INSIG
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry14
component stoichiometry: Stoichiometry17
component stoichiometry: Stoichiometry18
component: SCAP:cholesterol
component: INSIG
component: SREBP1A,1C,2
xref: UnificationXref47
xref: UnificationXref46
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655727

SequenceSite118
type: SequenceSite
position status: EQUAL
sequence position: 1

SREBF2:SCAP:INSIG2:oxysterol
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry7
component stoichiometry: Stoichiometry8
component stoichiometry: Stoichiometry9
component: SCAP tetramer
component: INSIG2:oxysterol
component: SRBP2_HUMAN
xref: UnificationXref23
xref: UnificationXref22
cellular location: endoplasmic reticulum membrane
display name: SREBP2:SCAP:INSIG2:oxysterol
comment: Reactome DB_ID: 2317523

SREBF1A,1C,2:SCAP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry11
component stoichiometry: Stoichiometry10
component: SCAP tetramer
component: SREBP1A,1C,2
xref: UnificationXref34
xref: UnificationXref35
cellular location: endoplasmic reticulum membrane
display name: SREBP1A,1C,2:SCAP
comment: Reactome DB_ID: 2326883

SCAP tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component: SCAP_CRIGR
xref: UnificationXref10
xref: UnificationXref11
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655722

INSIG2:oxysterol
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry4
component stoichiometry: Stoichiometry5
component: INSI2_HUMAN
component: oxysterol
xref: UnificationXref21
xref: UnificationXref20
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 2317521

SCAP:SREBF2
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry3
component stoichiometry: Stoichiometry1
component: SCAP tetramer
component: SRBP2_HUMAN
xref: UnificationXref12
xref: UnificationXref13
cellular location: endoplasmic reticulum membrane
display name: SCAP:SREBP2
comment: Reactome DB_ID: 2317524

SequenceSite120
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite121
type: SequenceSite
position status: EQUAL
sequence position: 393

SequenceSite122
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite126
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite125
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite124
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite123
type: SequenceSite
position status: EQUAL
sequence position: 765

SequenceSite129
type: SequenceSite
position status: EQUAL
sequence position: 1276

SequenceSite128
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite127
type: SequenceSite
position status: EQUAL
sequence position: 1094

SequenceSite132
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite133
type: SequenceSite
position status: EQUAL
sequence position: 2412

SequenceSite130
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite131
type: SequenceSite
position status: EQUAL
sequence position: 1141

SequenceSite175
type: SequenceSite
position status: EQUAL
sequence position: 78

SequenceSite174
type: SequenceSite
position status: EQUAL
sequence position: 2531

SequenceSite177
type: SequenceSite
position status: EQUAL
sequence position: 158

SequenceSite176
type: SequenceSite
position status: EQUAL
sequence position: 120

SequenceSite171
type: SequenceSite
position status: EQUAL
sequence position: 1362

SequenceSite170
type: SequenceSite
position status: EQUAL
sequence position: 1243

SequenceSite173
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite172
type: SequenceSite
position status: EQUAL
sequence position: 1402

SequenceSite167
type: SequenceSite
position status: EQUAL
sequence position: 1035

SequenceSite168
type: SequenceSite
position status: EQUAL
sequence position: 1159

SequenceSite169
type: SequenceSite
position status: EQUAL
sequence position: 1197

SequenceSite166
type: SequenceSite
position status: EQUAL
sequence position: 997

SequenceSite165
type: SequenceSite
position status: EQUAL
sequence position: 921

SequenceSite164
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite163
type: SequenceSite
position status: EQUAL
sequence position: 805

SequenceSite162
type: SequenceSite
position status: EQUAL
sequence position: 767

SequenceSite161
type: SequenceSite
position status: EQUAL
sequence position: 692

Guanosine 5'-diphosphate
type: SmallMoleculeReference
name: GDP
name: Guanosine diphosphate
name: GDP [ChEBI:17552]
xref: UnificationXref162

SequenceSite160
type: SequenceSite
position status: EQUAL
sequence position: 617

UnificationXref100
type: UnificationXref
id: P53992
db: UniProt

UnificationXref101
type: UnificationXref
id: 203987
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203987

SequenceSite158
type: SequenceSite
position status: EQUAL
sequence position: 349

UnificationXref102
type: UnificationXref
id: REACT_12899
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12899.2

SequenceSite159
type: SequenceSite
position status: EQUAL
sequence position: 466

UnificationXref103
type: UnificationXref
id: 1655768
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655768

SequenceSite156
type: SequenceSite
position status: EQUAL
sequence position: 232

UnificationXref104
type: UnificationXref
id: REACT_148034
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148034.1

SequenceSite157
type: SequenceSite
position status: EQUAL
sequence position: 311

Notch4
type: ProteinReference
name: Int-3
name: UniProt:P31695 Notch4
name: Int3
xref: UnificationXref153
comment: TISSUE SPECIFICITY Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.DEVELOPMENTAL STAGE Highly expressed in endothelial cells during embryonic development from 9.0 dpc.PTM Phosphorylated.DISEASE Loss of the extracellular domain causes constitutive activation of the Notch protein, which leads to hyperproliferation of glandular epithelial tissues and development of mammary carcinomas.SIMILARITY Belongs to the NOTCH family.SIMILARITY Contains 5 ANK repeats.SIMILARITY Contains 29 EGF-like domains.SIMILARITY Contains 3 LNR (Lin/Notch) repeats.
organism: Mus musculus

SequenceSite151
type: SequenceSite
position status: EQUAL
sequence position: 2318

UnificationXref109
type: UnificationXref
id: 1655747
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655747

SequenceSite150
type: SequenceSite
position status: EQUAL
sequence position: 40

UnificationXref108
type: UnificationXref
id: REACT_148424
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148424.1

SequenceSite153
type: SequenceSite
position status: EQUAL
sequence position: 1964

UnificationXref107
type: UnificationXref
id: 1655751
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655751

SequenceSite152
type: SequenceSite
position status: EQUAL
sequence position: 21

UnificationXref106
type: UnificationXref
id: REACT_148491
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148491.1

SequenceSite155
type: SequenceSite
position status: EQUAL
sequence position: 116

UnificationXref105
type: UnificationXref
id: 1655750
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655750

SequenceSite154
type: SequenceSite
position status: EQUAL
sequence position: 73

UnificationXref114
type: UnificationXref
id: REACT_147893
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147893.1

SequenceSite145
type: SequenceSite
position status: EQUAL
sequence position: 320

UnificationXref115
type: UnificationXref
id: CHEBI:16556
db: ChEBI

SequenceSite146
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref112
type: UnificationXref
id: REACT_148336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148336.1

SequenceSite147
type: SequenceSite
position status: EQUAL
sequence position: 2531

UnificationXref113
type: UnificationXref
id: 1655840
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655840

SequenceSite148
type: SequenceSite
position status: EQUAL
sequence position: 26

UnificationXref110
type: UnificationXref
id: REACT_148180
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148180.2

SequenceSite149
type: SequenceSite
position status: EQUAL
sequence position: 2470

UnificationXref111
type: UnificationXref
id: 1655759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655759

SequenceSite140
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref117
type: UnificationXref
id: REACT_22966
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22966.3

SequenceSite144
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref116
type: UnificationXref
id: 727815
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727815

SequenceSite143
type: SequenceSite
position status: EQUAL
sequence position: 334

UnificationXref119
type: UnificationXref
id: 727810
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727810

SequenceSite142
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref118
type: UnificationXref
id: CHEBI:17361
db: ChEBI

SequenceSite141
type: SequenceSite
position status: EQUAL
sequence position: 170

UnificationXref123
type: UnificationXref
id: 2032981
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032981

SequenceSite136
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref124
type: UnificationXref
id: REACT_120164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120164.1

SequenceSite137
type: SequenceSite
position status: EQUAL
sequence position: 2181

SequenceSite134
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref125
type: UnificationXref
id: 2032987
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032987

SequenceSite135
type: SequenceSite
position status: EQUAL
sequence position: 1521

UnificationXref126
type: UnificationXref
id: REACT_119065
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119065.1

UnificationXref120
type: UnificationXref
id: REACT_22895
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22895.2

UnificationXref121
type: UnificationXref
id: 2032984
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032984

SequenceSite138
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref122
type: UnificationXref
id: REACT_120048
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120048.1

SequenceSite139
type: SequenceSite
position status: EQUAL
sequence position: 1797

UnificationXref129
type: UnificationXref
id: 2032991
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032991

UnificationXref127
type: UnificationXref
id: 2032989
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032989

UnificationXref128
type: UnificationXref
id: REACT_119099
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119099.1

UnificationXref133
type: UnificationXref
id: REACT_119275
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119275.1

UnificationXref132
type: UnificationXref
id: 2032998
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032998

UnificationXref131
type: UnificationXref
id: Q80WK9
db: UniProt

UnificationXref130
type: UnificationXref
id: REACT_119448
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119448.1

UnificationXref137
type: UnificationXref
id: G3I3V5
db: UniProt

UnificationXref136
type: UnificationXref
id: REACT_119779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119779.1

UnificationXref135
type: UnificationXref
id: 2032999
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032999

UnificationXref134
type: UnificationXref
id: Q80WL0
db: UniProt

UnificationXref138
type: UnificationXref
id: 2032997
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2032997

UnificationXref139
type: UnificationXref
id: REACT_119098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119098.1

UnificationXref140
type: UnificationXref
id: 2033000
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2033000

UnificationXref142
type: UnificationXref
id: 2033005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2033005

UnificationXref141
type: UnificationXref
id: REACT_119184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119184.1

Beta-1,4-galactosyltransferase 1
type: ProteinReference
name: UniProt:Q99PC2 B4galt1
name: B4galt1
name: beta4GalT-1
xref: UnificationXref85
organism: Cricetulus griseus

UnificationXref144
type: UnificationXref
id: Q01705
db: UniProt

UnificationXref143
type: UnificationXref
id: REACT_118591
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118591.2

UnificationXref146
type: UnificationXref
id: REACT_119856
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119856.1

UnificationXref145
type: UnificationXref
id: 1984030
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1984030

UnificationXref148
type: UnificationXref
id: 1984029
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1984029

UnificationXref147
type: UnificationXref
id: O35516
db: UniProt

SequenceSite192
type: SequenceSite
position status: EQUAL
sequence position: 1199

SequenceSite193
type: SequenceSite
position status: EQUAL
sequence position: 1316

SequenceSite194
type: SequenceSite
position status: EQUAL
sequence position: 26

SequenceSite195
type: SequenceSite
position status: EQUAL
sequence position: 2470

SequenceSite196
type: SequenceSite
position status: EQUAL
sequence position: 174

SequenceSite197
type: SequenceSite
position status: EQUAL
sequence position: 212

INSIG2
type: ProteinReference
name: UniProt:Q9Y5U4 INSIG2
xref: UnificationXref17
comment: MISCELLANEOUS Does not require nuclear SREBPs for its expression. When nuclear SREBP activity is low, is the only form of INSIG present in the cell.SIMILARITY Belongs to the INSIG family.
organism: Homo sapiens

UnificationXref149
type: UnificationXref
id: REACT_119738
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119738.1

SequenceSite198
type: SequenceSite
position status: EQUAL
sequence position: 251

SequenceSite199
type: SequenceSite
position status: EQUAL
sequence position: 291

SequenceSite190
type: SequenceSite
position status: EQUAL
sequence position: 1075

SequenceSite191
type: SequenceSite
position status: EQUAL
sequence position: 1161

UnificationXref151
type: UnificationXref
id: 1984032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1984032

UnificationXref150
type: UnificationXref
id: Q61982
db: UniProt

UnificationXref159
type: UnificationXref
id: CHEBI:17009
db: ChEBI

UnificationXref158
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

SequenceSite189
type: SequenceSite
position status: EQUAL
sequence position: 1037

UnificationXref157
type: UnificationXref
id: REACT_118959
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118959.1

UnificationXref156
type: UnificationXref
id: 1984033
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1984033

UnificationXref155
type: UnificationXref
id: REACT_119852
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119852.1

UnificationXref154
type: UnificationXref
id: 1984031
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1984031

UnificationXref153
type: UnificationXref
id: P31695
db: UniProt

UnificationXref152
type: UnificationXref
id: REACT_119457
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119457.1

SequenceSite183
type: SequenceSite
position status: EQUAL
sequence position: 694

SequenceSite184
type: SequenceSite
position status: EQUAL
sequence position: 769

SequenceSite181
type: SequenceSite
position status: EQUAL
sequence position: 350

SequenceSite182
type: SequenceSite
position status: EQUAL
sequence position: 468

SequenceSite187
type: SequenceSite
position status: EQUAL
sequence position: 961

SequenceSite188
type: SequenceSite
position status: EQUAL
sequence position: 999

SequenceSite185
type: SequenceSite
position status: EQUAL
sequence position: 807

SequenceSite186
type: SequenceSite
position status: EQUAL
sequence position: 923

SequenceSite180
type: SequenceSite
position status: EQUAL
sequence position: 312

UnificationXref160
type: UnificationXref
id: 1463452
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1463452

UnificationXref162
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref161
type: UnificationXref
id: REACT_119248
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119248.2

UnificationXref168
type: UnificationXref
id: REACT_119580
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119580.1

UnificationXref167
type: UnificationXref
id: 1986542
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986542

SequenceSite179
type: SequenceSite
position status: EQUAL
sequence position: 233

UniProt:G3HM56 Notch3
type: ProteinReference
name: Notch3
name: I79_011804
xref: UnificationXref60
organism: Cricetulus griseus

SequenceSite178
type: SequenceSite
position status: EQUAL
sequence position: 197

UnificationXref169
type: UnificationXref
id: 1986553
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986553

UnificationXref164
type: UnificationXref
id: REACT_119366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119366.1

UnificationXref163
type: UnificationXref
id: 1467290
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1467290

UnificationXref166
type: UnificationXref
id: REACT_119409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119409.1

http://identifiers.org/pubmed/12963821
type: PublicationXref
id: 12963821
author: Brown, MS
author: Adams, CM
author: Goldstein, JL
db: Pubmed
title: Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
source: Proc Natl Acad Sci U S A 100:10647-52
year: 2003

UnificationXref165
type: UnificationXref
id: 1985704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1985704

UnificationXref174
type: UnificationXref
id: REACT_120130
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120130.1

UnificationXref175
type: UnificationXref
id: P83337
db: UniProt

UnificationXref176
type: UnificationXref
id: 5149526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5149526

UnificationXref177
type: UnificationXref
id: REACT_173078
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173078.1

UnificationXref178
type: UnificationXref
id: 1986584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986584

UnificationXref179
type: UnificationXref
id: REACT_118648
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118648.2

UnificationXref170
type: UnificationXref
id: REACT_119295
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119295.1

UnificationXref171
type: UnificationXref
id: 1986568
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986568

UnificationXref172
type: UnificationXref
id: REACT_119227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119227.1

UnificationXref173
type: UnificationXref
id: 1986582
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1986582

SRBP1_HUMAN
type: Protein
entity reference: SREBP1
data source: Reactome
name: Sterol regulatory element-binding protein 1C
name: SREBF1 isoform 3
name: SREBP1C
name: SREBF1-3
xref: UnificationXref30
xref: UnificationXref31
feature: FragmentFeature5
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655761
display name: SREBF1C

SRBP1_HUMAN
type: Protein
entity reference: SREBP1
data source: Reactome
name: SREBF1 isoform 1
name: SREBF1-1
name: Sterol regulatory element-binding protein 1A
name: SREBP1A
xref: UnificationXref28
xref: UnificationXref27
feature: FragmentFeature4
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655757
display name: SREBF1A

INSI1_HUMAN
type: Protein
entity reference: INSIG1
data source: Reactome
name: Insulin-induced gene 1 protein
xref: UnificationXref41
xref: UnificationXref40
feature: FragmentFeature6
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655735
display name: INSIG1

INSIG
type: Protein
data source: Reactome
member physical entity: INSI1_HUMAN
member physical entity: INSI2_HUMAN
xref: UnificationXref43
xref: UnificationXref42
cellular location: endoplasmic reticulum membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1655749

SCAP_CRIGR
type: Protein
entity reference: UniProt:P97260 SCAP
data source: Reactome
xref: UnificationXref8
xref: UnificationXref9
feature: FragmentFeature2
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655763
display name: SCAP

SRBP2_HUMAN
type: Protein
entity reference: SREBP2
data source: Reactome
name: SREBP2
name: Sterol regulatory element-binding protein 2
name: SREBF2(1-1141)
xref: UnificationXref4
xref: UnificationXref5
feature: FragmentFeature1
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655733
display name: SREBF2

SREBP1A,1C,2
type: Protein
data source: Reactome
member physical entity: SRBP1_HUMAN
member physical entity: SRBP2_HUMAN
xref: UnificationXref32
xref: UnificationXref33
cellular location: endoplasmic reticulum membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1655730
display name: SREBF1A,1C,2

INSI2_HUMAN
type: Protein
entity reference: INSIG2
data source: Reactome
name: Insulin-induced gene 2 protein
xref: UnificationXref18
xref: UnificationXref19
feature: FragmentFeature3
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655736
display name: INSIG2

UnificationXref180
type: UnificationXref
id: 1655838
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655838

UnificationXref181
type: UnificationXref
id: REACT_147890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147890.1

UniProt:P83337 POFUT1
type: ProteinReference
name: POFUT1
xref: UnificationXref175
comment: PATHWAY Protein modification; protein glycosylation.SIMILARITY Belongs to the glycosyltransferase 68 family.
organism: Cricetulus griseus

http://identifiers.org/pubmed/11524432
type: PublicationXref
id: 11524432
author: Shi, S
author: Shao, L
author: Wang, Y
author: Harris, RJ
author: Stanley, P
author: Spellman, MW
author: Haltiwanger, RS
db: Pubmed
title: Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
source: J Biol Chem 276:40338-45
year: 2001

SREBF2:SCAP Transits to the Golgi
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref114
xref: UnificationXref113
xref: http://identifiers.org/pubmed/12842885
left: SREBP2:SCAP:CopII Coat
display name: SREBP2:SCAP Transits to the Golgi
comment: Authored: May, B, 2011-09-28
comment: Edited: May, B, 2011-09-28
comment: In low concentrations of cholesterol SCAP interacts with Sec24 of the CopII coat complex causing SCAP:SREBP1A/1C/2 to be transported with the CopII complex from the endoplasmic reticulum to the Golgi.
right: SCAP:SREBF2

Galactosylation of Pre-Notch
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.1.38
xref: http://identifiers.org/pubmed/11707585
xref: UnificationXref91
xref: UnificationXref92
left: UDP-D-galactopyranose
left: Glc,GlcNAc-Fuc-Pre-Notch
comment: Edited: Orlic-Milacic, M, 2012-02-10
comment: Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14
comment: Using Chinese hamster (Cricetulus griseus) ovarian cell lines deficient in different galactosyltransferases, Chen et al. established that beta-4-galactosyltransferase 1 (B4galt1) was necessary for galactosylation of beta 1,3-linked N-acetylglucosaminyl group added by fringe enzymes to O-linked fucosyl residues on Notch1. B4galt1-mediated galactosylation of Notch1 was necessary for fringe-induced modulation of Notch1 signaling. Since the genome of C. griseus has not been completely sequenced, it is possible that annotated C. griseus Notch isoforms do not represent full-length proteins. Annotated C. griseus Notch2 in particular seems truncated. Only those fucosylation and glycosylation sites that are conserved between Chinese hamster, mouse, human and rat are shown. Since the exact preference, if any, of fringe enzymes for Notch O-fucose sites is not known, the extension of an O-fucosyl residue at an unknown position is shown.
comment: Reviewed: Haw, R, 2012-02-06
comment: Edited: D'Eustachio, P, 2012-02-06
right: UDP
right: Glc,Gal-GlcNAc-Fuc-Pre-Notch

SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/15452130
xref: http://identifiers.org/pubmed/12963821
xref: http://identifiers.org/pubmed/15899885
xref: UnificationXref49
xref: UnificationXref48
xref: http://identifiers.org/pubmed/9242699
xref: http://identifiers.org/pubmed/15728349
xref: http://identifiers.org/pubmed/12202038
xref: http://identifiers.org/pubmed/12842885
participant stoichiometry: Stoichiometry13
participant stoichiometry: Stoichiometry12
left: SREBF1A,1C,2:SCAP
left: INSIG
left: Cholesterol
comment: Authored: May, B, 2012-06-10
comment: Edited: May, B, 2012-06-10
comment: SREBPs (SREBP1A/1C/2, SREBFs) bind SCAP in the endoplasmic reticulum membrane. Luminal loop 1 of SCAP binds cholesterol (Adams et al. 2003) which prevents SCAP from interacting with Sec24 in the CopII coat complex and allows SCAP to interact with INSIG instead (Sakai et al. 1997, Yang et al. 2002, Dobrosotskaya et al. 2003, Adams et al. 2004, Feramisco et al. 2005, Sun et al. 2005). These interactions retain SCAP:SREBP1A/1C/2 in the endoplasmic reticulum.
right: SREBP1A,1C,2:SCAP:cholesterol:INSIG

SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/17428920
xref: http://identifiers.org/pubmed/15452130
xref: UnificationXref25
xref: UnificationXref24
participant stoichiometry: Stoichiometry6
left: INSIG2:oxysterol
left: SCAP:SREBF2
comment: Authored: May, B, 2012-06-10
comment: Edited: May, B, 2012-06-10
comment: INSIG binds oxysterols and the INSIG:oxysterol complex interacts with SCAP subunits of the SREBP2:SCAP (SREBF2:SCAP) complex (Adams et al. 2004, Radhakrishnan et al. 2007). This interaction retains the SREBP2:SCAP:INSIG:oxysterol complex in the endoplasmic reticulum. From this reaction it is inferred that SREBP1A (SREBF1A) and SREBP1C (SREBF1C) are retained similarly.
right: SREBF2:SCAP:INSIG2:oxysterol

SREBF2:SCAP Binds CopII Coat Complex
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/12242332
xref: http://identifiers.org/pubmed/12193656
xref: http://identifiers.org/pubmed/15260976
xref: UnificationXref180
xref: UnificationXref181
xref: http://identifiers.org/pubmed/15452130
xref: http://identifiers.org/pubmed/12963821
xref: http://identifiers.org/pubmed/15899885
xref: http://identifiers.org/pubmed/17428919
xref: http://identifiers.org/pubmed/9242699
xref: http://identifiers.org/pubmed/15728349
xref: http://identifiers.org/pubmed/12202038
xref: http://identifiers.org/pubmed/19041766
xref: http://identifiers.org/pubmed/21454655
xref: http://identifiers.org/pubmed/12842885
participant stoichiometry: Stoichiometry30
participant stoichiometry: Stoichiometry31
participant stoichiometry: Stoichiometry32
left: SC23A_MOUSE
left: SAR1B_CRIGR
left: S24C_HUMAN
left: SCAP:SREBF2
display name: SREBP2:SCAP Binds CopII Coat Complex
comment: Authored: May, B, 2011-09-28
comment: Edited: May, B, 2011-09-28
comment: SREBP2 (SREBF2 and by inference SREBP1A and SREBP1C) is a transmembrane protein that binds SCAP in the endoplasmic reticulum membrane (Sakai et al. 1997). In the presence of cholesterol or oxysterols SCAP:SREBP2 binds INSIG and is retained in the endoplasmic reticulum (Espenshade et al. 2002, Yabe et al. 2002, Yang et al. 2002, Adams et al. 2003, Dobrosotskaya et al. 2003, Adams et al. 2004, Radhakrishnan et al. 2004, Sun et al. 2005, Sun et al. 2007, Motamed et al. 2011). At cholesterol concentrations below 5 mol% SCAP changes conformation, SCAP:SREBP2 loses interaction with INSIG, binds the CopII coat complex, and is translocated to the Golgi (Adams et al 2004, Feramisco et al. 2005, Radhakrishnan et al. 2008, Motamed et al. 2011).
right: SREBP2:SCAP:CopII Coat

Fucosylation of Pre-Notch by POFUT1
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
EC number: 2.4.1.221
xref: http://identifiers.org/pubmed/12486116
xref: http://identifiers.org/pubmed/21464368
xref: http://identifiers.org/pubmed/15692013
xref: UnificationXref178
xref: UnificationXref179
xref: http://identifiers.org/pubmed/11524432
xref: http://identifiers.org/pubmed/18347015
participant stoichiometry: Stoichiometry29
participant stoichiometry: Stoichiometry28
left: GDP-L-fucose
left: Noth precursors
comment: Edited: Orlic-Milacic, M, 2012-02-10
comment: Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14
comment: Reviewed: Haw, R, 2012-02-06
comment: Edited: D'Eustachio, P, 2012-02-06
comment: In the endoplasmic reticulum, Notch receptor precursors are fucosylated on conserved serine and threonine residues in their EGF repeats. The consensus fucosylation site sequence is C2-X(4-5)-S/T-C3, where C2 and C3 are the second and third cysteine residue within the EGF repeat, and X(4-5) is four to five amino acid residues of any type. Only those fucosylation sites that are conserved between human, mouse and rat Notch isoforms are annotated. Fucosylation is performed by the endoplasmic reticulum resident O-fucosyl transferase POFUT1. Fucosylation by POFUT1, initially discovered in Drosophila, is considered to be an essential step in Notch processing and production of a fully functional receptor. Fucosylation of mammalian Notch proteins was studied by exogenously expressing mouse Notch1 in Chinese hamster ovary cell lines.
right: Guanosine 5'-Diphosphate
right: Fucosylated Notch precursors

Sialylation of Pre-Notch
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: UnificationXref142
xref: UnificationXref143
xref: http://identifiers.org/pubmed/10935626
xref: http://identifiers.org/pubmed/11530204
left: CMP-sialic acid
left: Glc,Gal-GlcNAc-Fuc-Pre-Notch
comment: Edited: Orlic-Milacic, M, 2012-02-10
comment: Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14
comment: Using Chinese hamster (Cricetulus griseus) ovary cells that express endogenous Notch1 but do not express endogenous Fringe proteins, Moloney et al. found after introduction of mouse Mfng that mature Notch1 had the Sia-alpha2,3-Gal-beta1,4-GlcNAc-beta1,3-fucitol tetrasaccharide attached to conserved serine and threonine residues in EGF repeats of Notch1 (Moloney et al. 2000). Sialyltransferases that could be involved in formation of this type of tetrasaccharide are St3gal3, St3gal4 and St3gal6 (Harduin-Lepers et al. 2001).
comment: Reviewed: Haw, R, 2012-02-06
comment: Edited: D'Eustachio, P, 2012-02-06
right: Cytidine-5'-monophosphate
right: Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch

http://identifiers.org/pubmed/21454655
type: PublicationXref
id: 21454655
author: Wang, ML
author: Brown, MS
author: Zhang, Y
author: Kwon, HJ
author: Motamed, M
author: Goldstein, JL
author: Seemann, J
db: Pubmed
title: Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis
source: J Biol Chem 286:18002-12
year: 2011

http://identifiers.org/pubmed/17428919
type: PublicationXref
id: 17428919
author: Sun, LP
author: Brown, MS
author: Goldstein, JL
author: Seemann, J
db: Pubmed
title: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
source: Proc Natl Acad Sci U S A 104:6519-26
year: 2007

http://identifiers.org/pubmed/10935626
type: PublicationXref
id: 10935626
author: Shao, L
author: Wang, Y
author: Johnston, SH
author: Panin, VM
author: Moloney, DJ
author: Vogt, TF
author: Wilson, R
author: Stanley, P
author: Irvine, KD
author: Chen, J
author: Haltiwanger, RS
db: Pubmed
title: Fringe is a glycosyltransferase that modifies Notch
source: Nature 406:369-75
year: 2000

http://identifiers.org/pubmed/15452130
type: PublicationXref
id: 15452130
author: Brown, MS
author: Reitz, J
author: Adams, CM
author: Feramisco, JD
author: De Brabander, JK
author: Goldstein, JL
author: Li, L
db: Pubmed
title: Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
source: J Biol Chem 279:52772-80
year: 2004

Golgi membrane
type: CellularLocationVocabulary
xref: UnificationXref50

Glc,GlcNAc-Fuc-Pre-Notch
type: Protein
data source: Reactome
member physical entity: Glc,GlcNAc-Fuc-Pre-Notch3
member physical entity: Glc,GlcNAc-Fuc-Pre-Notch4
member physical entity: Glc,GlcNAc-Fuc-Pre-Notch1
member physical entity: Glc,GlcNAc-Fuc-Pre-Notch2
xref: UnificationXref66
xref: UnificationXref67
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032302
comment: Converted from EntitySet in Reactome

Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch4
type: Protein
entity reference: Notch4
data source: Reactome
xref: UnificationXref127
xref: UnificationXref128
feature: ModificationFeature90
feature: ModificationFeature77
feature: ModificationFeature84
feature: ModificationFeature78
feature: ModificationFeature85
feature: ModificationFeature86
feature: ModificationFeature79
feature: ModificationFeature87
feature: ModificationFeature93
feature: ModificationFeature80
feature: FragmentFeature24
feature: ModificationFeature94
feature: ModificationFeature81
feature: ModificationFeature91
feature: ModificationFeature82
feature: ModificationFeature92
feature: ModificationFeature83
feature: ModificationFeature103
feature: ModificationFeature89
feature: ModificationFeature74
feature: ModificationFeature88
feature: ModificationFeature73
feature: ModificationFeature76
feature: ModificationFeature75
cellular location: Golgi lumen
comment: Reactome DB_ID: 2032989

St3gal3/4/6
type: Protein
data source: Reactome
member physical entity: St3gal3
member physical entity: St3gal4
member physical entity: St3gal6
xref: UnificationXref140
xref: UnificationXref141
cellular location: Golgi membrane
comment: Reactome DB_ID: 2033000
comment: Converted from EntitySet in Reactome

St3gal3
type: Protein
entity reference: UniProt:Q80WK9 St3gal3
data source: Reactome
xref: UnificationXref133
xref: UnificationXref132
feature: FragmentFeature25
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032998

http://identifiers.org/pubmed/19041766
type: PublicationXref
id: 19041766
author: Brown, MS
author: Goldstein, JL
author: McDonald, JG
author: Radhakrishnan, A
db: Pubmed
title: Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance
source: Cell Metab 8:512-21
year: 2008

http://identifiers.org/pubmed/17428920
type: PublicationXref
id: 17428920
author: Brown, MS
author: Kwon, Hyock Joo
author: Radhakrishnan, Arun
author: Ikeda, Yukio
author: Goldstein, JL
db: Pubmed
title: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
source: Proc. Natl. Acad. Sci. U.S.A. 104:6511-8
year: 2007

Pre-Notch4
type: Protein
entity reference: Notch4
data source: Reactome
xref: UnificationXref155
xref: UnificationXref154
feature: FragmentFeature31
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1984031

Fucosylated Notch precursors
type: Protein
data source: Reactome
member physical entity: Fucosylated Notch4 precursor
member physical entity: Fucosylated Notch3 precursor
member physical entity: Fucosylated Notch2 precursor
member physical entity: Fucosylated Notch1 precursor
xref: UnificationXref174
xref: UnificationXref173
cellular location: endoplasmic reticulum membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1986582
display name: Fuc-Pre-Notch

Pre-Notch2
type: Protein
entity reference: UniProt:O35516 Notch2
data source: Reactome
xref: UnificationXref149
xref: UnificationXref148
feature: FragmentFeature29
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1984029

Pre-Notch3
type: Protein
entity reference: Notch3
data source: Reactome
xref: UnificationXref151
xref: UnificationXref152
feature: FragmentFeature30
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1984032

Noth precursors
type: Protein
data source: Reactome
member physical entity: Pre-Notch4
member physical entity: Pre-Notch2
member physical entity: Pre-Notch3
member physical entity: Pre-Notch1
xref: UnificationXref157
xref: UnificationXref156
cellular location: endoplasmic reticulum membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1984033
display name: Pre-Notch

Pre-Notch1
type: Protein
entity reference: Notch1
data source: Reactome
xref: UnificationXref146
xref: UnificationXref145
feature: FragmentFeature28
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1984030

St3gal4
type: Protein
entity reference: UniProt:Q80WL0 St3gal4
data source: Reactome
xref: UnificationXref136
xref: UnificationXref135
feature: FragmentFeature26
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032999

St3gal6
type: Protein
entity reference: I79_018123
data source: Reactome
xref: UnificationXref138
xref: UnificationXref139
feature: FragmentFeature27
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032997

Sec23
type: ProteinReference
name: UniProt:Q01405 Sec23a
name: Sec23r
name: Sec23a
xref: UnificationXref94
comment: TISSUE SPECIFICITY High levels in brain and fibroblasts.SIMILARITY Belongs to the SEC23/SEC24 family. SEC23 subfamily.
organism: Mus musculus

B4galt1
type: Protein
entity reference: Beta-1,4-galactosyltransferase 1
data source: Reactome
xref: UnificationXref86
xref: UnificationXref87
feature: FragmentFeature15
cellular location: Golgi membrane
comment: Reactome DB_ID: 2023200

Glc,Gal-GlcNAc-Fuc-Pre-Notch4
type: Protein
entity reference: Notch4
data source: Reactome
xref: UnificationXref79
xref: UnificationXref78
feature: ModificationFeature90
feature: ModificationFeature77
feature: ModificationFeature84
feature: ModificationFeature78
feature: ModificationFeature85
feature: ModificationFeature86
feature: ModificationFeature79
feature: ModificationFeature87
feature: ModificationFeature93
feature: ModificationFeature80
feature: ModificationFeature94
feature: ModificationFeature81
feature: ModificationFeature91
feature: ModificationFeature82
feature: ModificationFeature92
feature: ModificationFeature83
feature: FragmentFeature14
feature: ModificationFeature89
feature: ModificationFeature74
feature: ModificationFeature88
feature: ModificationFeature73
feature: ModificationFeature76
feature: ModificationFeature99
feature: ModificationFeature75
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032275

NOTCH1
type: ProteinReference
name: UniProt:G3I6Z6 NOTCH1
xref: UnificationXref51
comment: PTM Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. Monoubiquitination at Lys-1765 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch.SIMILARITY Belongs to the NOTCH family.SIMILARITY Contains 5 ANK repeats.SIMILARITY Contains 35 EGF-like domains.SIMILARITY Contains 3 LNR (Lin/Notch) repeats.
organism: Cricetulus griseus

SC23A_MOUSE
type: Protein
entity reference: Sec23
data source: Reactome
name: Protein transport protein Sec23A
xref: UnificationXref96
xref: UnificationXref95
feature: FragmentFeature16
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655767
display name: Sec23a

Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch
type: Protein
data source: Reactome
member physical entity: Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch4
member physical entity: Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch1
member physical entity: Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch2
member physical entity: Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch3
xref: UnificationXref129
xref: UnificationXref130
cellular location: Golgi lumen
comment: Reactome DB_ID: 2032991
comment: Converted from EntitySet in Reactome

Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch1
type: Protein
entity reference: NOTCH1
data source: Reactome
xref: UnificationXref121
xref: UnificationXref122
feature: ModificationFeature16
feature: ModificationFeature33
feature: ModificationFeature15
feature: ModificationFeature18
feature: ModificationFeature17
feature: ModificationFeature12
feature: ModificationFeature11
feature: ModificationFeature14
feature: ModificationFeature13
feature: ModificationFeature19
feature: ModificationFeature100
feature: ModificationFeature10
feature: ModificationFeature30
feature: ModificationFeature31
feature: ModificationFeature32
feature: ModificationFeature25
feature: ModificationFeature24
feature: ModificationFeature23
feature: ModificationFeature22
feature: ModificationFeature29
feature: ModificationFeature28
feature: ModificationFeature27
feature: ModificationFeature26
feature: FragmentFeature21
feature: ModificationFeature8
feature: ModificationFeature9
feature: ModificationFeature4
feature: ModificationFeature5
feature: ModificationFeature6
feature: ModificationFeature7
feature: ModificationFeature20
feature: ModificationFeature1
feature: ModificationFeature21
feature: ModificationFeature2
feature: ModificationFeature3
cellular location: Golgi lumen
comment: Reactome DB_ID: 2032984

UniProt:O35516 Notch2
type: ProteinReference
name: Notch2
xref: UnificationXref147
comment: TISSUE SPECIFICITY Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.PTM Hydroxylated by HIF1AN.SIMILARITY Belongs to the NOTCH family.SIMILARITY Contains 6 ANK repeats.SIMILARITY Contains 35 EGF-like domains.SIMILARITY Contains 3 LNR (Lin/Notch) repeats.
organism: Mus musculus

Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch2
type: Protein
entity reference: UniProt:G3HP78 Notch2
data source: Reactome
xref: UnificationXref123
xref: UnificationXref124
feature: ModificationFeature43
feature: ModificationFeature42
feature: ModificationFeature41
feature: ModificationFeature36
feature: ModificationFeature40
feature: ModificationFeature35
feature: ModificationFeature38
feature: ModificationFeature37
feature: ModificationFeature101
feature: ModificationFeature39
feature: ModificationFeature44
feature: FragmentFeature22
cellular location: Golgi lumen
comment: Reactome DB_ID: 2032981

Glc,Sia-Gal-GlcNAc-Fuc-Pre-Notch3
type: Protein
entity reference: UniProt:G3HM56 Notch3
data source: Reactome
xref: UnificationXref125
xref: UnificationXref126
feature: ModificationFeature59
feature: ModificationFeature55
feature: ModificationFeature56
feature: ModificationFeature57
feature: ModificationFeature58
feature: ModificationFeature52
feature: ModificationFeature70
feature: ModificationFeature51
feature: ModificationFeature54
feature: ModificationFeature71
feature: ModificationFeature53
feature: ModificationFeature102
feature: ModificationFeature50
feature: ModificationFeature68
feature: ModificationFeature69
feature: ModificationFeature48
feature: ModificationFeature66
feature: ModificationFeature49
feature: ModificationFeature67
feature: ModificationFeature46
feature: ModificationFeature47
feature: FragmentFeature23
feature: ModificationFeature61
feature: ModificationFeature60
feature: ModificationFeature65
feature: ModificationFeature64
feature: ModificationFeature63
feature: ModificationFeature62
cellular location: Golgi lumen
comment: Reactome DB_ID: 2032987

SAR1B_CRIGR
type: Protein
entity reference: SAR1
data source: Reactome
xref: UnificationXref99
xref: UnificationXref98
feature: FragmentFeature17
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1655715
display name: SAR1B

S24C_HUMAN
type: Protein
entity reference: KIAA0079
data source: Reactome
name: Protein transport protein Sec24C
xref: UnificationXref101
xref: UnificationXref102
feature: FragmentFeature18
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 203987
display name: SEC24C

SCAP_CRIGR
type: Protein
entity reference: UniProt:P97260 SCAP
data source: Reactome
xref: UnificationXref106
xref: UnificationXref105
feature: FragmentFeature19
cellular location: Golgi membrane
comment: Reactome DB_ID: 1655750
display name: SCAP

SRBP2_HUMAN
type: Protein
entity reference: SREBP2
data source: Reactome
name: SREBP2
name: Sterol regulatory element-binding protein 2
name: SREBF2(1-1141)
xref: UnificationXref110
xref: UnificationXref109
feature: FragmentFeature20
cellular location: Golgi membrane
comment: Reactome DB_ID: 1655747
display name: SREBF2

Cholesterol
type: SmallMolecule
entity reference: cholest-5-en-3beta-ol
data source: Reactome
xref: UnificationXref38
xref: UnificationXref37
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 193384
display name: CHOL

oxysterol
type: SmallMolecule
entity reference: oxysterol
data source: Reactome
xref: UnificationXref16
xref: UnificationXref15
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 2317518

UDP-D-galactopyranose
type: SmallMolecule
entity reference: UDP-D-galactose [ChEBI:18307]
data source: Reactome
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref70
xref: UnificationXref71
cellular location: Golgi lumen
comment: Reactome DB_ID: 735682
display name: UDP-Gal

UDP
type: SmallMolecule
entity reference: UDP
data source: Reactome
xref: UnificationXref83
xref: UnificationXref84
cellular location: Golgi lumen
comment: Reactome DB_ID: 205687

CMP-sialic acid
type: SmallMolecule
entity reference: CMP-N-acetylneuraminate [ChEBI:3278]
data source: Reactome
xref: UnificationXref117
xref: UnificationXref116
cellular location: Golgi lumen
comment: Reactome DB_ID: 727815
display name: CMP-Neu5Ac

Cytidine-5'-monophosphate
type: SmallMolecule
entity reference: CMP [ChEBI:17361]
data source: Reactome
name: cytidine 5'-monophosphate
name: cytidylic acid
xref: UnificationXref120
xref: UnificationXref119
cellular location: Golgi lumen
comment: Reactome DB_ID: 727810
display name: CMP

http://identifiers.org/pubmed/11707585
type: PublicationXref
id: 11707585
author: Moloney, DJ
author: Stanley, P
author: Chen, J
db: Pubmed
title: Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
source: Proc Natl Acad Sci U S A 98:13716-21
year: 2001

GDP-L-fucose
type: SmallMolecule
entity reference: GDP-L-fucose
data source: Reactome
xref: UnificationXref160
xref: UnificationXref161
cellular location: endoplasmic reticulum lumen
comment: Reactome DB_ID: 1463452
display name: GDP-Fuc

Guanosine 5'-Diphosphate
type: SmallMolecule
entity reference: Guanosine 5'-diphosphate
data source: Reactome
name: Guanosine Diphosphate
xref: UnificationXref164
xref: UnificationXref163
cellular location: endoplasmic reticulum lumen
comment: Reactome DB_ID: 1467290
display name: GDP

Glc,GlcNAc-Fuc-Pre-Notch3
type: Protein
entity reference: UniProt:G3HM56 Notch3
data source: Reactome
xref: UnificationXref61
xref: UnificationXref62
feature: ModificationFeature59
feature: ModificationFeature55
feature: ModificationFeature56
feature: ModificationFeature57
feature: ModificationFeature58
feature: ModificationFeature52
feature: ModificationFeature70
feature: ModificationFeature51
feature: ModificationFeature72
feature: ModificationFeature54
feature: ModificationFeature71
feature: ModificationFeature53
feature: ModificationFeature50
feature: ModificationFeature68
feature: FragmentFeature9
feature: ModificationFeature69
feature: ModificationFeature48
feature: ModificationFeature66
feature: ModificationFeature49
feature: ModificationFeature67
feature: ModificationFeature46
feature: ModificationFeature47
feature: ModificationFeature61
feature: ModificationFeature60
feature: ModificationFeature65
feature: ModificationFeature64
feature: ModificationFeature63
feature: ModificationFeature62
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032281

Glc,GlcNAc-Fuc-Pre-Notch4
type: Protein
entity reference: Notch4
data source: Reactome
xref: UnificationXref64
xref: UnificationXref65
feature: ModificationFeature90
feature: ModificationFeature77
feature: ModificationFeature84
feature: ModificationFeature78
feature: ModificationFeature85
feature: ModificationFeature95
feature: ModificationFeature86
feature: ModificationFeature79
feature: ModificationFeature87
feature: ModificationFeature93
feature: ModificationFeature80
feature: ModificationFeature94
feature: ModificationFeature81
feature: ModificationFeature91
feature: ModificationFeature82
feature: ModificationFeature92
feature: ModificationFeature83
feature: ModificationFeature89
feature: ModificationFeature74
feature: FragmentFeature10
feature: ModificationFeature88
feature: ModificationFeature73
feature: ModificationFeature76
feature: ModificationFeature75
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032283

Glc,GlcNAc-Fuc-Pre-Notch1
type: Protein
entity reference: NOTCH1
data source: Reactome
xref: UnificationXref55
xref: UnificationXref56
feature: ModificationFeature34
feature: ModificationFeature16
feature: ModificationFeature33
feature: ModificationFeature15
feature: ModificationFeature18
feature: ModificationFeature17
feature: ModificationFeature12
feature: ModificationFeature11
feature: ModificationFeature14
feature: ModificationFeature13
feature: ModificationFeature19
feature: ModificationFeature10
feature: ModificationFeature30
feature: ModificationFeature31
feature: ModificationFeature32
feature: ModificationFeature25
feature: ModificationFeature24
feature: ModificationFeature23
feature: ModificationFeature22
feature: ModificationFeature29
feature: ModificationFeature28
feature: ModificationFeature27
feature: ModificationFeature26
feature: FragmentFeature7
feature: ModificationFeature8
feature: ModificationFeature9
feature: ModificationFeature4
feature: ModificationFeature5
feature: ModificationFeature6
feature: ModificationFeature7
feature: ModificationFeature20
feature: ModificationFeature1
feature: ModificationFeature21
feature: ModificationFeature2
feature: ModificationFeature3
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032277

Glc,GlcNAc-Fuc-Pre-Notch2
type: Protein
entity reference: UniProt:G3HP78 Notch2
data source: Reactome
xref: UnificationXref59
xref: UnificationXref58
feature: ModificationFeature43
feature: ModificationFeature42
feature: ModificationFeature41
feature: ModificationFeature36
feature: ModificationFeature40
feature: ModificationFeature35
feature: ModificationFeature38
feature: ModificationFeature37
feature: ModificationFeature39
feature: FragmentFeature8
feature: ModificationFeature44
feature: ModificationFeature45
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032279

Glc,Gal-GlcNAc-Fuc-Pre-Notch2
type: Protein
entity reference: UniProt:G3HP78 Notch2
data source: Reactome
xref: UnificationXref74
xref: UnificationXref75
feature: ModificationFeature43
feature: ModificationFeature42
feature: ModificationFeature41
feature: ModificationFeature36
feature: FragmentFeature12
feature: ModificationFeature40
feature: ModificationFeature35
feature: ModificationFeature38
feature: ModificationFeature37
feature: ModificationFeature39
feature: ModificationFeature97
feature: ModificationFeature44
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032271

Glc,Gal-GlcNAc-Fuc-Pre-Notch3
type: Protein
entity reference: UniProt:G3HM56 Notch3
data source: Reactome
xref: UnificationXref77
xref: UnificationXref76
feature: ModificationFeature59
feature: ModificationFeature98
feature: ModificationFeature55
feature: ModificationFeature56
feature: ModificationFeature57
feature: ModificationFeature58
feature: FragmentFeature13
feature: ModificationFeature52
feature: ModificationFeature70
feature: ModificationFeature51
feature: ModificationFeature54
feature: ModificationFeature71
feature: ModificationFeature53
feature: ModificationFeature50
feature: ModificationFeature68
feature: ModificationFeature69
feature: ModificationFeature48
feature: ModificationFeature66
feature: ModificationFeature49
feature: ModificationFeature67
feature: ModificationFeature46
feature: ModificationFeature47
feature: ModificationFeature61
feature: ModificationFeature60
feature: ModificationFeature65
feature: ModificationFeature64
feature: ModificationFeature63
feature: ModificationFeature62
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032274

Glc,Gal-GlcNAc-Fuc-Pre-Notch
type: Protein
data source: Reactome
member physical entity: Glc,Gal-GlcNAc-Fuc-Pre-Notch4
member physical entity: Glc,Gal-GlcNAc-Fuc-Pre-Notch2
member physical entity: Glc,Gal-GlcNAc-Fuc-Pre-Notch3
member physical entity: Glc,Gal-GlcNAc-Fuc-Pre-Notch1
xref: UnificationXref81
xref: UnificationXref80
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032300
comment: Converted from EntitySet in Reactome

Glc,Gal-GlcNAc-Fuc-Pre-Notch1
type: Protein
entity reference: NOTCH1
data source: Reactome
xref: UnificationXref73
xref: UnificationXref72
feature: ModificationFeature16
feature: ModificationFeature33
feature: ModificationFeature15
feature: ModificationFeature18
feature: ModificationFeature17
feature: ModificationFeature12
feature: ModificationFeature11
feature: ModificationFeature14
feature: ModificationFeature13
feature: ModificationFeature96
feature: ModificationFeature19
feature: FragmentFeature11
feature: ModificationFeature10
feature: ModificationFeature30
feature: ModificationFeature31
feature: ModificationFeature32
feature: ModificationFeature25
feature: ModificationFeature24
feature: ModificationFeature23
feature: ModificationFeature22
feature: ModificationFeature29
feature: ModificationFeature28
feature: ModificationFeature27
feature: ModificationFeature26
feature: ModificationFeature8
feature: ModificationFeature9
feature: ModificationFeature4
feature: ModificationFeature5
feature: ModificationFeature6
feature: ModificationFeature7
feature: ModificationFeature20
feature: ModificationFeature1
feature: ModificationFeature21
feature: ModificationFeature2
feature: ModificationFeature3
cellular location: Golgi membrane
comment: Reactome DB_ID: 2032269

SAR1
type: ProteinReference
name: SARA2
name: SAR1B
name: UniProt:Q9QVY3 SAR1B
xref: UnificationXref97
comment: SIMILARITY Belongs to the small GTPase superfamily. SAR1 family.
organism: Cricetulus griseus

UniProt:Q80WK9 St3gal3
type: ProteinReference
name: St3gal3
xref: UnificationXref131
organism: Cricetulus griseus

UniProt:Q80WL0 St3gal4
type: ProteinReference
name: St3gal4
xref: UnificationXref134
organism: Cricetulus griseus

http://identifiers.org/pubmed/21464368
type: PublicationXref
id: 21464368
author: Lowe, JB
author: Wang, W
author: Yao, D
author: Xin, W
author: Gerson, S
author: Wei, L
author: Yan, Q
author: Huang, Y
author: Stanley, P
author: Zhou, L
author: Huang, X
db: Pubmed
title: Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
source: Blood 117:5652-62
year: 2011

Notch1
type: ProteinReference
name: UniProt:Q01705 Notch1
name: Motch
xref: UnificationXref144
comment: PTM Phosphorylated.PTM Hydroxylated at Asn-1945 and Asn-2012 by HIF1AN. Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD.SIMILARITY Belongs to the NOTCH family.SIMILARITY Contains 5 ANK repeats.SIMILARITY Contains 36 EGF-like domains.SIMILARITY Contains 3 LNR (Lin/Notch) repeats.
organism: Mus musculus

http://identifiers.org/pubmed/12842885
type: PublicationXref
id: 12842885
author: Brown, MS
author: Dobrosotskaya, IY
author: Rawson, RB
author: Goldstein, JL
db: Pubmed
title: Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
source: J Biol Chem 278:35837-43
year: 2003

http://identifiers.org/pubmed/12193656
type: PublicationXref
id: 12193656
author: Espenshade, PJ
author: Li, WP
author: Yabe, D
db: Pubmed
title: Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
source: Proc Natl Acad Sci U S A 99:11694-9
year: 2002

http://identifiers.org/pubmed/11530204
type: PublicationXref
id: 11530204
author: Delannoy, P
author: Julien, S
author: Vallejo-Ruiz, V
author: Krzewinski-Recchi, MA
author: Harduin-Lepers, A
author: Samyn-Petit, B
db: Pubmed
title: The human sialyltransferase family
source: Biochimie 83:727-37
year: 2001

http://identifiers.org/pubmed/18347015
type: PublicationXref
id: 18347015
author: Shi, S
author: Stahl, M
author: Ge, C
author: Uemura, K
author: Stanley, P
author: Tashima, Y
db: Pubmed
title: Roles of Pofut1 and O-fucose in mammalian Notch signaling
source: J Biol Chem 283:13638-51
year: 2008

http://identifiers.org/pubmed/15728349
type: PublicationXref
id: 15728349
author: Brown, MS
author: Reitz, J
author: Feramisco, JD
author: Goldstein, JL
author: Ikeda, Y
author: Radhakrishnan, A
db: Pubmed
title: Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change
source: Proc Natl Acad Sci U S A 102:3242-7
year: 2005

Notch4
type: ProteinReference
name: UniProt:G3HZC0 Notch4
name: I79_016419
xref: UnificationXref63
organism: Cricetulus griseus

O-glucosyl-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref54

SequenceSite202
type: SequenceSite
position status: EQUAL
sequence position: 672

SequenceSite203
type: SequenceSite
position status: EQUAL
sequence position: 749

SequenceSite200
type: SequenceSite
position status: EQUAL
sequence position: 329

SequenceSite201
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite206
type: SequenceSite
position status: EQUAL
sequence position: 1099

SequenceSite207
type: SequenceSite
position status: EQUAL
sequence position: 1137

SequenceSite204
type: SequenceSite
position status: EQUAL
sequence position: 864

SequenceSite205
type: SequenceSite
position status: EQUAL
sequence position: 939

SequenceSite208
type: SequenceSite
position status: EQUAL
sequence position: 1182

SequenceSite209
type: SequenceSite
position status: EQUAL
sequence position: 1350

SequenceSite210
type: SequenceSite
position status: EQUAL
sequence position: 40

Stoichiometry30
type: Stoichiometry
physical entity: SC23A_MOUSE
stoichiometric coefficient: 4.0

Stoichiometry31
type: Stoichiometry
physical entity: SAR1B_CRIGR
stoichiometric coefficient: 4.0

Stoichiometry32
type: Stoichiometry
physical entity: S24C_HUMAN
stoichiometric coefficient: 4.0

O-fucosyl-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref53

O-fucosyl-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref52

Stoichiometry13
type: Stoichiometry
physical entity: INSIG
stoichiometric coefficient: 4.0

Stoichiometry12
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 4.0

Stoichiometry15
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 4.0

Stoichiometry14
type: Stoichiometry
physical entity: SREBP1A,1C,2
stoichiometric coefficient: 4.0

Stoichiometry11
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

Stoichiometry10
type: Stoichiometry
physical entity: SREBP1A,1C,2
stoichiometric coefficient: 1.0

SequenceSite233
type: SequenceSite
position status: EQUAL
sequence position: 392

Stoichiometry17
type: Stoichiometry
physical entity: SCAP:cholesterol
stoichiometric coefficient: 1.0

Stoichiometry16
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

Stoichiometry19
type: Stoichiometry
physical entity: B4galt1
stoichiometric coefficient: 2.0

Stoichiometry18
type: Stoichiometry
physical entity: INSIG
stoichiometric coefficient: 4.0

Stoichiometry26
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref90

Stoichiometry25
type: Stoichiometry
physical entity: SCAP_CRIGR
stoichiometric coefficient: 4.0

Stoichiometry24
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

Stoichiometry23
type: Stoichiometry
physical entity: S24C_HUMAN
stoichiometric coefficient: 4.0

Stoichiometry22
type: Stoichiometry
physical entity: SRBP2_HUMAN
stoichiometric coefficient: 4.0

Stoichiometry21
type: Stoichiometry
physical entity: SAR1B_CRIGR
stoichiometric coefficient: 4.0

Stoichiometry20
type: Stoichiometry
physical entity: SC23A_MOUSE
stoichiometric coefficient: 4.0

Stoichiometry29
type: Stoichiometry
physical entity: Guanosine 5'-Diphosphate
stoichiometric coefficient: 70.0

Stoichiometry28
type: Stoichiometry
physical entity: GDP-L-fucose
stoichiometric coefficient: 70.0

Stoichiometry27
type: Stoichiometry
physical entity: SRBP2_HUMAN
stoichiometric coefficient: 4.0

Homo sapiens
type: BioSource
xref: UnificationXref2

Stoichiometry7
type: Stoichiometry
physical entity: SRBP2_HUMAN
stoichiometric coefficient: 4.0

Stoichiometry8
type: Stoichiometry
physical entity: INSIG2:oxysterol
stoichiometric coefficient: 4.0

UniProt:G3HP78 Notch2
type: ProteinReference
name: I79_012584
name: Notch2
xref: UnificationXref57
organism: Cricetulus griseus

Stoichiometry9
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: SCAP tetramer
stoichiometric coefficient: 1.0

SequenceSite219
type: SequenceSite
position status: EQUAL
sequence position: 448

Stoichiometry4
type: Stoichiometry
physical entity: oxysterol
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: INSI2_HUMAN
stoichiometric coefficient: 1.0

Stoichiometry6
type: Stoichiometry
physical entity: INSIG2:oxysterol
stoichiometric coefficient: 4.0

SequenceSite216
type: SequenceSite
position status: EQUAL
sequence position: 287

SequenceSite215
type: SequenceSite
position status: EQUAL
sequence position: 245

SequenceSite218
type: SequenceSite
position status: EQUAL
sequence position: 366

SequenceSite217
type: SequenceSite
position status: EQUAL
sequence position: 328

SequenceSite212
type: SequenceSite
position status: EQUAL
sequence position: 37

SequenceSite211
type: SequenceSite
position status: EQUAL
sequence position: 2318

SequenceSite214
type: SequenceSite
position status: EQUAL
sequence position: 207

SequenceSite213
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite220
type: SequenceSite
position status: EQUAL
sequence position: 486

SequenceSite221
type: SequenceSite
position status: EQUAL
sequence position: 600

POFUT1
type: Protein
entity reference: UniProt:P83337 POFUT1
data source: Reactome
xref: UnificationXref176
xref: UnificationXref177
feature: FragmentFeature36
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 5149526

Fucosylated Notch4 precursor
type: Protein
entity reference: Notch4
data source: Reactome
xref: UnificationXref171
xref: UnificationXref172
feature: ModificationFeature159
feature: ModificationFeature158
feature: ModificationFeature169
feature: ModificationFeature168
feature: ModificationFeature167
feature: ModificationFeature157
feature: ModificationFeature166
feature: FragmentFeature35
feature: ModificationFeature156
feature: ModificationFeature165
feature: ModificationFeature161
feature: ModificationFeature162
feature: ModificationFeature172
feature: ModificationFeature163
feature: ModificationFeature173
feature: ModificationFeature164
feature: ModificationFeature170
feature: ModificationFeature171
feature: ModificationFeature160
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1986568
display name: Fuc-Pre-Notch4

SequenceSite229
type: SequenceSite
position status: EQUAL
sequence position: 1141

SequenceSite228
type: SequenceSite
position status: EQUAL
sequence position: 1056

SequenceSite227
type: SequenceSite
position status: EQUAL
sequence position: 978

SequenceSite226
type: SequenceSite
position status: EQUAL
sequence position: 940

SequenceSite225
type: SequenceSite
position status: EQUAL
sequence position: 817

Fucosylated Notch3 precursor
type: Protein
entity reference: Notch3
data source: Reactome
xref: UnificationXref169
xref: UnificationXref170
feature: ModificationFeature145
feature: ModificationFeature146
feature: ModificationFeature143
feature: ModificationFeature144
feature: ModificationFeature149
feature: ModificationFeature147
feature: ModificationFeature148
feature: FragmentFeature34
feature: ModificationFeature155
feature: ModificationFeature154
feature: ModificationFeature153
feature: ModificationFeature152
feature: ModificationFeature142
feature: ModificationFeature151
feature: ModificationFeature150
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1986553
display name: Fuc-Pre-Notch3

SequenceSite224
type: SequenceSite
position status: EQUAL
sequence position: 778

Fucosylated Notch2 precursor
type: Protein
entity reference: UniProt:O35516 Notch2
data source: Reactome
xref: UnificationXref168
xref: UnificationXref167
feature: ModificationFeature127
feature: ModificationFeature132
feature: ModificationFeature128
feature: ModificationFeature133
feature: ModificationFeature125
feature: ModificationFeature134
feature: ModificationFeature126
feature: ModificationFeature135
feature: ModificationFeature136
feature: ModificationFeature123
feature: ModificationFeature137
feature: ModificationFeature124
feature: ModificationFeature138
feature: ModificationFeature139
feature: FragmentFeature33
feature: ModificationFeature129
feature: ModificationFeature131
feature: ModificationFeature130
feature: ModificationFeature140
feature: ModificationFeature141
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1986542
display name: Fuc-Pre-Notch2

SequenceSite223
type: SequenceSite
position status: EQUAL
sequence position: 740

Fucosylated Notch1 precursor
type: Protein
entity reference: Notch1
data source: Reactome
xref: UnificationXref166
xref: UnificationXref165
feature: ModificationFeature114
feature: ModificationFeature115
feature: ModificationFeature116
feature: ModificationFeature117
feature: ModificationFeature110
feature: ModificationFeature111
feature: ModificationFeature121
feature: ModificationFeature112
feature: ModificationFeature122
feature: ModificationFeature113
feature: FragmentFeature32
feature: ModificationFeature118
feature: ModificationFeature119
feature: ModificationFeature104
feature: ModificationFeature106
feature: ModificationFeature105
feature: ModificationFeature120
feature: ModificationFeature108
feature: ModificationFeature107
feature: ModificationFeature109
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 1985704
display name: Fuc-Pre-Notch1

SequenceSite222
type: SequenceSite
position status: EQUAL
sequence position: 702

SequenceSite231
type: SequenceSite
position status: EQUAL
sequence position: 1964

SequenceSite232
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite230
type: SequenceSite
position status: EQUAL
sequence position: 21

Stoichiometry2
type: Stoichiometry
physical entity: SCAP_CRIGR
stoichiometric coefficient: 4.0

Stoichiometry1
type: Stoichiometry
physical entity: SRBP2_HUMAN
stoichiometric coefficient: 4.0