UniProt:H2L2L3
type: ProteinReference
xref: UnificationXref17840
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

http://identifiers.org/pubmed/8774846
type: PublicationXref
id: 8774846
author: Cohen, P
author: Young, P R
author: Clifton, A D
db: Pubmed
title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
source: FEBS Lett. 392:209-14
year: 1996

UniProt:D3KFU0
type: ProteinReference
xref: UnificationXref7968
organism: http://identifiers.org/taxonomy/6239

UniProt:D3KFU1
type: ProteinReference
xref: UnificationXref23106
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

UniProt:D3KFS6
type: ProteinReference
xref: UnificationXref9194
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/11818547
type: PublicationXref
id: 11818547
author: Hill, V
author: Gao, ZH
author: Virshup, DM
author: Yochum, A
author: Seeling, JM
db: Pubmed
title: Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex
source: Proc Natl Acad Sci U S A 99:1182-7
year: 2002

UniProt:H2L2J8
type: ProteinReference
xref: UnificationXref15787
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L2J9
type: ProteinReference
xref: UnificationXref15781
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BKX8
type: ProteinReference
name: Y22D7AR.6
xref: UnificationXref7543
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BL92
type: ProteinReference
name: Y18H1A.3
xref: UnificationXref499
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

UniProt:Q9BKW0
type: ProteinReference
name: Y92H12BL.4
xref: UnificationXref23785
organism: http://identifiers.org/taxonomy/6239

vps-4
type: ProteinReference
name: UniProt:Q9BL83
xref: UnificationXref430
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BKW4
type: ProteinReference
name: Y92H12A.2
xref: UnificationXref6619
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9188469
type: PublicationXref
id: 9188469
author: Cupillard, L
author: Matteï, MG
author: Koumanov, K
author: Lazdunski, M
author: Lambeau, G
db: Pubmed
title: Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
source: J Biol Chem 272:15745-52
year: 1997

Y37E3.3
type: ProteinReference
name: UniProt:Q9GR61
xref: UnificationXref18799
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

UniProt:H2L2C9
type: ProteinReference
xref: UnificationXref15201
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L2C8
type: ProteinReference
xref: UnificationXref15197
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/17726023
type: PublicationXref
id: 17726023
author: Florio, V
author: Uher, L
author: Wolda, SL
author: Radwanski, PB
author: McCaw, KN
author: Hambleton, R
author: Vandeput, F
author: Krall, J
author: Movsesian, MA
db: Pubmed
title: Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes
source: J Biol Chem 282:32749-57
year: 2007

Y65B4A.8
type: ProteinReference
name: UniProt:Q9BL56
xref: UnificationXref6026
organism: http://identifiers.org/taxonomy/6239

UnificationXref18589
type: UnificationXref
id: 427498
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=427498

UnificationXref18588
type: UnificationXref
id: CHEBI:76279
db: ChEBI

UniProt:H2L2C1
type: ProteinReference
xref: UnificationXref25505
organism: http://identifiers.org/taxonomy/6239

UnificationXref18587
type: UnificationXref
id: REACT_205400
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205400.2

UnificationXref18586
type: UnificationXref
id: 5650624
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650624

UniProt:H2L2C3
type: ProteinReference
xref: UnificationXref25507
organism: http://identifiers.org/taxonomy/6239

UnificationXref18585
type: UnificationXref
id: 5650617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650617

UniProt:H2L2C2
type: ProteinReference
xref: UnificationXref25501
organism: http://identifiers.org/taxonomy/6239

UnificationXref18584
type: UnificationXref
id: 5634013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5634013

UnificationXref18593
type: UnificationXref
id: 5653535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653535

UnificationXref18594
type: UnificationXref
id: REACT_205771
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205771.2

UnificationXref18591
type: UnificationXref
id: 5650623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650623

UnificationXref18592
type: UnificationXref
id: REACT_205673
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205673.2

UnificationXref18590
type: UnificationXref
id: REACT_201016
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201016.1

http://identifiers.org/pubmed/20803696
type: PublicationXref
id: 20803696
author: Kaibuchi, Kozo
author: Amano, Mutsuki
author: Nakayama, Masanori
db: Pubmed
title: Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
source: Cytoskeleton (Hoboken) 67:545-54
year: 2010

Y82E9BR.3
type: ProteinReference
name: UniProt:Q9BKS0
xref: UnificationXref21967
organism: http://identifiers.org/taxonomy/6239

elc-1
type: ProteinReference
name: UniProt:Q9BKS1
xref: UnificationXref18206
organism: http://identifiers.org/taxonomy/6239

UnificationXref18599
type: UnificationXref
id: 5649798
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649798

UniProt:Q9BL46
type: ProteinReference
name: Y71H2AM.11
xref: UnificationXref13427
organism: http://identifiers.org/taxonomy/6239

UnificationXref18596
type: UnificationXref
id: REACT_223878
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223878.2

UniProt:H2L2D3
type: ProteinReference
xref: UnificationXref9988
organism: http://identifiers.org/taxonomy/6239

UnificationXref18595
type: UnificationXref
id: 5653536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653536

tRNA Aminoacylation
type: Pathway
data source: Provenance1
pathway component: REACT 256226.1
pathway component: REACT 236789.1
evidence: Evidence2515
xref: RelationshipXref2023
xref: UnificationXref20096
xref: UnificationXref20097
pathway order: PathwayStep2497
pathway order: PathwayStep2476
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref18598
type: UnificationXref
id: 5649797
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649797

UnificationXref18597
type: UnificationXref
id: Q21029
db: UniProt

UniProt:Q9BL73
type: ProteinReference
name: ppk-2
xref: UnificationXref10115
organism: http://identifiers.org/taxonomy/6239

Polymerase switching
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction83
pathway component: BiochemicalReaction81
pathway component: BiochemicalReaction82
evidence: Evidence131
xref: UnificationXref1390
xref: UnificationXref1389
pathway order: PathwayStep129
pathway order: PathwayStep128
pathway order: PathwayStep127
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/18382465
type: PublicationXref
id: 18382465
author: Moss, SJ
author: Jurd, R
author: Jacob, TC
db: Pubmed
title: GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition
source: Nat Rev Neurosci 9:331-43
year: 2008

UnificationXref18565
type: UnificationXref
id: 5653538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653538

UnificationXref18564
type: UnificationXref
id: REACT_249638
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249638.1

UnificationXref18563
type: UnificationXref
id: 5652277
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652277

UnificationXref18562
type: UnificationXref
id: 5652276
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652276

UniProt:Q9BL79
type: ProteinReference
name: Y48G1C.4
xref: UnificationXref9875
organism: http://identifiers.org/taxonomy/6239

UnificationXref18569
type: UnificationXref
id: 5650629
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650629

UnificationXref18568
type: UnificationXref
id: REACT_202699
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202699.2

UnificationXref18567
type: UnificationXref
id: 5653539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653539

UnificationXref18566
type: UnificationXref
id: REACT_212296
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_212296.2

UnificationXref18571
type: UnificationXref
id: REACT_223482
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_223482.2

UnificationXref18572
type: UnificationXref
id: 5650598
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650598

UnificationXref18570
type: UnificationXref
id: 5650631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650631

UniProt:Q9BKU2
type: ProteinReference
name: Y37E3.11
xref: UnificationXref9524
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BL61
type: ProteinReference
name: Y65B4A.6
xref: UnificationXref20190
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BKU3
type: ProteinReference
name: Y37E3.10
xref: UnificationXref20789
organism: http://identifiers.org/taxonomy/6239

Y65B4A.3
type: ProteinReference
name: UniProt:Q9BL60
xref: UnificationXref402
organism: http://identifiers.org/taxonomy/6239

UnificationXref18574
type: UnificationXref
id: REACT_235969
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235969.1

UniProt:Q9BL69
type: ProteinReference
name: est-1
xref: UnificationXref20437
organism: http://identifiers.org/taxonomy/6239

UnificationXref18573
type: UnificationXref
id: 5650600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650600

UnificationXref18576
type: UnificationXref
id: H2KZB0
db: UniProt

UnificationXref18575
type: UnificationXref
id: 5651576
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651576

Y37E3.8
type: ProteinReference
name: UniProt:Q9BKU6
xref: UnificationXref20245
organism: http://identifiers.org/taxonomy/6239

UnificationXref18578
type: UnificationXref
id: Q965G5
db: UniProt

Y37E3.8
type: ProteinReference
name: UniProt:Q9BKU5
xref: UnificationXref20243
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

UnificationXref18577
type: UnificationXref
id: 5626305
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626305

UniProt:Q9BL68
type: ProteinReference
name: est-1
xref: UnificationXref20435
organism: http://identifiers.org/taxonomy/6239

UnificationXref18579
type: UnificationXref
id: 5626307
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626307

UnificationXref18580
type: UnificationXref
id: 5626308
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626308

UnificationXref18581
type: UnificationXref
id: 5651578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651578

UnificationXref18582
type: UnificationXref
id: REACT_226971
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226971.2

UnificationXref18583
type: UnificationXref
id: Q21921
db: UniProt

UniProt:H2L2G2
type: ProteinReference
xref: UnificationXref24010
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BL11
type: ProteinReference
name: Y48G8AL.1
xref: UnificationXref25691
organism: http://identifiers.org/taxonomy/6239

rpl-17
type: ProteinReference
name: UniProt:Q9BL19
xref: UnificationXref20241
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L2H3
type: ProteinReference
xref: UnificationXref12471
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BL02
type: ProteinReference
name: ceh-44
xref: UnificationXref3245
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L2H2
type: ProteinReference
xref: UnificationXref12469
organism: http://identifiers.org/taxonomy/6239

Synthesis of Ketone Bodies
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction783
pathway component: BiochemicalReaction785
pathway component: BiochemicalReaction784
evidence: Evidence1122
xref: UnificationXref8442
xref: RelationshipXref748
xref: UnificationXref8443
pathway order: PathwayStep1114
pathway order: PathwayStep1116
pathway order: PathwayStep1115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/5289249
type: PublicationXref
id: 5289249
author: Lapière, CM
author: Lenaers, A
author: Kohn, LD
db: Pubmed
title: Procollagen peptidase: an enzyme excising the coordination peptides of procollagen
source: Proc Natl Acad Sci U S A 68:3054-8
year: 1971

UniProt:Q9BL07
type: ProteinReference
name: Y54F10AM.8
xref: UnificationXref9578
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BKR9
type: ProteinReference
name: Y82E9BR.16
xref: UnificationXref16912
organism: http://identifiers.org/taxonomy/6239

Y71H2AM.17
type: ProteinReference
name: UniProt:Q9BL39
xref: UnificationXref14771
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BL36
type: ProteinReference
name: Y71H2AM.6
xref: UnificationXref6009
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

UniProt:H2L2F5
type: ProteinReference
xref: UnificationXref31476
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L2F6
type: ProteinReference
xref: UnificationXref31484
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

UniProt:H2L2F7
type: ProteinReference
xref: UnificationXref31480
organism: http://identifiers.org/taxonomy/6239

UnificationXref18518
type: UnificationXref
id: 5651634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651634

UnificationXref18517
type: UnificationXref
id: 5651633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651633

UnificationXref18516
type: UnificationXref
id: 5651628
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651628

UnificationXref18515
type: UnificationXref
id: 5651627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651627

UnificationXref18519
type: UnificationXref
id: 5651636
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651636

UnificationXref18510
type: UnificationXref
id: 5651622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651622

UnificationXref18514
type: UnificationXref
id: 5651626
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651626

UnificationXref18513
type: UnificationXref
id: 5651625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651625

UnificationXref18512
type: UnificationXref
id: 5651624
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651624

UnificationXref18511
type: UnificationXref
id: 5651623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651623

UnificationXref18505
type: UnificationXref
id: 5651630
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651630

UnificationXref18504
type: UnificationXref
id: G5EF88
db: UniProt

UnificationXref18507
type: UnificationXref
id: 5651631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651631

UnificationXref18506
type: UnificationXref
id: Q68TI8
db: UniProt

UnificationXref18509
type: UnificationXref
id: 5651621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651621

UnificationXref18508
type: UnificationXref
id: 5651632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651632

UnificationXref18501
type: UnificationXref
id: 5651611
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651611

UnificationXref18500
type: UnificationXref
id: 5651610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651610

UnificationXref18503
type: UnificationXref
id: 5651629
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651629

UnificationXref18502
type: UnificationXref
id: G5EEV7
db: UniProt

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

UniProt:H2L292
type: ProteinReference
xref: UnificationXref17747
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L293
type: ProteinReference
xref: UnificationXref17751
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12445824
type: PublicationXref
id: 12445824
author: Ganapathy, V
author: Inoue, K
author: Zhuang, L
db: Pubmed
title: Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function
source: Biochem Biophys Res Commun 299:465-71
year: 2002

UniProt:H2L289
type: ProteinReference
xref: UnificationXref17757
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L283
type: ProteinReference
xref: UnificationXref17759
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L284
type: ProteinReference
xref: UnificationXref17755
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L282
type: ProteinReference
xref: UnificationXref17753
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L288
type: ProteinReference
xref: UnificationXref17745
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L285
type: ProteinReference
xref: UnificationXref17769
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L286
type: ProteinReference
xref: UnificationXref17765
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L291
type: ProteinReference
xref: UnificationXref17749
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L290
type: ProteinReference
xref: UnificationXref17767
organism: http://identifiers.org/taxonomy/6239

UniProt:B5BM25
type: ProteinReference
xref: UnificationXref20404
organism: http://identifiers.org/taxonomy/6239

UniProt:B5BM23
type: ProteinReference
xref: UnificationXref20410
organism: http://identifiers.org/taxonomy/6239

UnificationXref18561
type: UnificationXref
id: 5652275
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652275

UniProt:B5BM24
type: ProteinReference
xref: UnificationXref20412
organism: http://identifiers.org/taxonomy/6239

UnificationXref18560
type: UnificationXref
id: 5652274
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652274

UnificationXref18553
type: UnificationXref
id: REACT_244262
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244262.1

UnificationXref18554
type: UnificationXref
id: 5650638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650638

UnificationXref18551
type: UnificationXref
id: 5650616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650616

UnificationXref18552
type: UnificationXref
id: 5650633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650633

UnificationXref18557
type: UnificationXref
id: 5650641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650641

UnificationXref18558
type: UnificationXref
id: REACT_205835
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205835.2

UnificationXref18555
type: UnificationXref
id: 5650639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650639

UnificationXref18556
type: UnificationXref
id: 5650640
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650640

UnificationXref18559
type: UnificationXref
id: O45418
db: UniProt

UnificationXref18550
type: UnificationXref
id: 5650615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650615

http://identifiers.org/pubmed/15005707
type: PublicationXref
id: 15005707
author: Ishigatsubo, Y
author: Yamaji, S
author: Yoshimi, R
author: Miwa, Y
author: Tanaka, J
author: Ueda, A
author: Ohno, S
author: Kaneko, T
author: Suzuki, A
author: Mishima, W
db: Pubmed
title: The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor
source: Genes Cells 9:193-204
year: 2004

UnificationXref18540
type: UnificationXref
id: REACT_204294
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204294.2

http://identifiers.org/pubmed/2328723
type: PublicationXref
id: 2328723
author: Rubartelli, A
author: Sitia, R
author: Talio, M
author: Cozzolino, F
db: Pubmed
title: A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence
source: EMBO J 9:1503-10
year: 1990

UnificationXref18541
type: UnificationXref
id: 5651613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651613

UnificationXref18542
type: UnificationXref
id: 5651614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651614

UnificationXref18543
type: UnificationXref
id: 5650609
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650609

UnificationXref18544
type: UnificationXref
id: 5650605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650605

UnificationXref18545
type: UnificationXref
id: 5650610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650610

UnificationXref18546
type: UnificationXref
id: 5650621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650621

UnificationXref18547
type: UnificationXref
id: 5651616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651616

UnificationXref18548
type: UnificationXref
id: REACT_220913
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220913.2

UnificationXref18549
type: UnificationXref
id: 5650614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650614

UniProt:B5BM47
type: ProteinReference
xref: UnificationXref10462
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/17477549
type: PublicationXref
id: 17477549
author: Wolthers, Kirsten R
author: Scrutton, Nigel S
db: Pubmed
title: Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
source: Biochemistry 46:6696-709
year: 2007

UnificationXref18535
type: UnificationXref
id: 5620920
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5620920

UnificationXref18536
type: UnificationXref
id: Q20774
db: UniProt

UnificationXref18533
type: UnificationXref
id: 5651604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651604

UnificationXref18534
type: UnificationXref
id: P09446
db: UniProt

UnificationXref18531
type: UnificationXref
id: 5650607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650607

UnificationXref18532
type: UnificationXref
id: 5650608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650608

UnificationXref18530
type: UnificationXref
id: O45246
db: UniProt

UnificationXref18539
type: UnificationXref
id: 5651612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651612

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

UnificationXref18537
type: UnificationXref
id: 5650604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650604

UnificationXref18538
type: UnificationXref
id: 5651605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651605

http://identifiers.org/pubmed/2914937
type: PublicationXref
id: 2914937
author: Zhang, Z
author: Korenfeld, C
author: Roman, D
author: Strauss, AW
author: Haas, RC
author: Perryman, B
db: Pubmed
title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase
source: J Biol Chem 264:2890-7
year: 1989

UniProt:B5BM30
type: ProteinReference
xref: UnificationXref12888
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/18555778
type: PublicationXref
id: 18555778
author: Aarden, Lucien A
author: Mooi, Wolter J
author: Vredeveld, Liesbeth C W
author: Michaloglou, Chrysiis
author: Peeper, Daniel S
author: Douma, Sirith
author: Desmet, Christophe J
author: Kuilman, Thomas
author: van Doorn, Remco
db: Pubmed
title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
source: Cell 133:1019-31
year: 2008

UnificationXref18522
type: UnificationXref
id: 5651608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651608

http://identifiers.org/pubmed/18555777
type: PublicationXref
id: 18555777
author: Augert, Arnaud
author: Popov, Nikolay
author: Takatsu, Yoshihiro
author: Gil, Jesús
author: Acosta, Juan C
author: Banito, Ana
author: Da Costa, Marco
author: Melamed, Jonathan
author: Guijarro, Maria V
author: Raguz, Selina
author: Fumagalli, Marzia
author: Brown, Celia
author: O'Loghlen, Ana
author: Hernando, Eva
author: d'Adda di Fagagna, Fabrizio
author: Bernard, David
db: Pubmed
title: Chemokine signaling via the CXCR2 receptor reinforces senescence
source: Cell 133:1006-18
year: 2008

UnificationXref18523
type: UnificationXref
id: 5651618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651618

UnificationXref18524
type: UnificationXref
id: REACT_207367
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_207367.2

UnificationXref18525
type: UnificationXref
id: 5650620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650620

UnificationXref18520
type: UnificationXref
id: REACT_202282
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202282.2

UnificationXref18521
type: UnificationXref
id: 5651607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651607

UnificationXref18526
type: UnificationXref
id: Q9U3B7
db: UniProt

UnificationXref18527
type: UnificationXref
id: 5650637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650637

UnificationXref18528
type: UnificationXref
id: G5ECU5
db: UniProt

UnificationXref18529
type: UnificationXref
id: 5650606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650606

http://identifiers.org/pubmed/20215114
type: PublicationXref
id: 20215114
author: Czirják, G
author: Enyedi, P
db: Pubmed
title: TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways
source: J Biol Chem 285:14549-57
year: 2010

http://identifiers.org/pubmed/9199344
type: PublicationXref
id: 9199344
author: DeFranco, AL
author: Harmer, SL
db: Pubmed
title: Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
source: Mol Cell Biol 17:4087-95
year: 1997

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

http://identifiers.org/pubmed/11851405
type: PublicationXref
id: 11851405
author: Lin, Zheng
author: Liu, Alice Y-C
author: Manalo, Dominador J
db: Pubmed
title: Redox-dependent regulation of the conformation and function of human heat shock factor 1
source: Biochemistry 41:2580-8
year: 2002

UniProt:Q9BLA0
type: ProteinReference
name: C36E6.1
xref: UnificationXref20658
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

sap-1
type: ProteinReference
name: UniProt:Q9BLB6
xref: UnificationXref19568
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L266
type: ProteinReference
xref: UnificationXref25674
organism: http://identifiers.org/taxonomy/6239

cyb-2.2
type: ProteinReference
name: UniProt:Q9BLB5
xref: UnificationXref860
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L265
type: ProteinReference
xref: UnificationXref25670
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

http://identifiers.org/pubmed/3931076
type: PublicationXref
id: 3931076
author: Wogan, G N
author: Zhu, J Q
author: Chen, J S
author: Groopman, J D
author: Donahue, P R
db: Pubmed
title: Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography
source: Proc. Natl. Acad. Sci. U.S.A. 82:6492-6
year: 1985

UniProt:Q9GRZ2
type: ProteinReference
name: Y59A8B.6
xref: UnificationXref19604
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9792106
type: PublicationXref
id: 9792106
author: Hazlett, TL
author: Sanchez, SA
author: Jameson, DM
author: Brunet, JE
db: Pubmed
title: Aggregation states of mitochondrial malate dehydrogenase
source: Protein Sci 7:2184-2189
year: 1998

UniProt:Q9GRV5
type: ProteinReference
name: trp-4
xref: UnificationXref7274
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/1371879
type: PublicationXref
id: 1371879
author: Duronio, V
author: Abraham, S
author: Schrader, JW
author: Welham, MJ
author: Dryden, P
db: Pubmed
title: p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
source: Proc Natl Acad Sci U S A 89:1587-91
year: 1992

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

http://identifiers.org/pubmed/11389444
type: PublicationXref
id: 11389444
author: Wrana, JL
author: Causing, CG
author: Kavsak, P
author: Luo, K
author: Bonni, S
author: Stroschein, SL
author: Wang, HR
db: Pubmed
title: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
source: Nat Cell Biol 3:587-95
year: 2001

http://identifiers.org/pubmed/17854762
type: PublicationXref
id: 17854762
author: Nelson, WJ
author: Hartsock, A
db: Pubmed
title: Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
source: Biochim Biophys Acta 1778:660-9
year: 2008

UnificationXref18686
type: UnificationXref
id: 5625043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625043

UnificationXref18685
type: UnificationXref
id: 5625042
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625042

UnificationXref18684
type: UnificationXref
id: Q7Z1P1
db: UniProt

UnificationXref18683
type: UnificationXref
id: 5625038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625038

UnificationXref18689
type: UnificationXref
id: REACT_261743
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261743.1

UnificationXref18688
type: UnificationXref
id: 5625069
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625069

UnificationXref18687
type: UnificationXref
id: 5625067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625067

UnificationXref18692
type: UnificationXref
id: 5625015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625015

UnificationXref18693
type: UnificationXref
id: 5625016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625016

UnificationXref18690
type: UnificationXref
id: 5625009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625009

UnificationXref18691
type: UnificationXref
id: 5625012
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625012

UnificationXref18695
type: UnificationXref
id: REACT_194532
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_194532.3

UnificationXref18694
type: UnificationXref
id: 5636057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636057

http://identifiers.org/pubmed/17785525
type: PublicationXref
id: 17785525
author: Boyault, Cyril
author: Garrido, Carmen
author: Gilquin, Benoit
author: Kwon, So Hee
author: Caron, Cécile
author: Fritah, Sabrina
author: Khochbin, Saadi
author: Vourc'h, Claire
author: Yao, Tso-Pang
author: Matthias, Patrick
author: Zhang, Yu
db: Pubmed
title: HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
source: Genes Dev. 21:2172-81
year: 2007

UnificationXref18697
type: UnificationXref
id: 5624973
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624973

UnificationXref18696
type: UnificationXref
id: G5ECU7
db: UniProt

UnificationXref18699
type: UnificationXref
id: 5624975
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624975

UnificationXref18698
type: UnificationXref
id: G5EF64
db: UniProt

UniProt:Q9BK23
type: ProteinReference
name: glr-3
xref: UnificationXref15385
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BK22
type: ProteinReference
name: glr-4
xref: UnificationXref15433
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BK21
type: ProteinReference
name: glr-5
xref: UnificationXref15378
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9BK20
type: ProteinReference
name: glr-6
xref: UnificationXref15423
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/20127491
type: PublicationXref
id: 20127491
author: Owsianik, Grzegorz
author: Nilius, Bernd
db: Pubmed
title: Transient receptor potential channelopathies
source: Pflugers Arch. 460:437-50
year: 2010

http://identifiers.org/pubmed/15621726
type: PublicationXref
id: 15621726
author: Chen, D
author: Mundy, GR
author: Zhao, M
db: Pubmed
title: Bone morphogenetic proteins
source: Growth Factors 22:233-41
year: 2004

UnificationXref18613
type: UnificationXref
id: 5636054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636054

UnificationXref18612
type: UnificationXref
id: G5EDF7
db: UniProt

UnificationXref18611
type: UnificationXref
id: 5649807
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649807

UnificationXref18610
type: UnificationXref
id: REACT_235928
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235928.1

UnificationXref18619
type: UnificationXref
id: 5649809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649809

UnificationXref18618
type: UnificationXref
id: 5636033
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636033

UnificationXref18617
type: UnificationXref
id: 5636032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636032

UnificationXref18616
type: UnificationXref
id: 5636029
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636029

UnificationXref18615
type: UnificationXref
id: 5636056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636056

UnificationXref18614
type: UnificationXref
id: 5636055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636055

UnificationXref18600
type: UnificationXref
id: CHEBI:26523
db: ChEBI

UnificationXref18602
type: UnificationXref
id: REACT_76566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76566.1

UnificationXref18601
type: UnificationXref
id: 1250243
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1250243

UnificationXref18608
type: UnificationXref
id: 5649803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649803

UnificationXref18607
type: UnificationXref
id: 5649802
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649802

UnificationXref18609
type: UnificationXref
id: 5649806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649806

UnificationXref18604
type: UnificationXref
id: REACT_203926
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_203926.2

UnificationXref18603
type: UnificationXref
id: 5649804
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649804

UnificationXref18606
type: UnificationXref
id: Q23356
db: UniProt

UnificationXref18605
type: UnificationXref
id: 5649805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649805

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

UnificationXref18631
type: UnificationXref
id: 5636009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636009

UnificationXref18630
type: UnificationXref
id: 5636008
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636008

UnificationXref18635
type: UnificationXref
id: H2KZI0
db: UniProt

UnificationXref18634
type: UnificationXref
id: 5636038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636038

UnificationXref18633
type: UnificationXref
id: O44408
db: UniProt

UnificationXref18632
type: UnificationXref
id: 5636010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636010

UnificationXref18639
type: UnificationXref
id: 5627758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5627758

UnificationXref18638
type: UnificationXref
id: 5636041
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636041

UnificationXref18637
type: UnificationXref
id: 5636040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636040

UnificationXref18636
type: UnificationXref
id: 5636039
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636039

http://identifiers.org/pubmed/9199292
type: PublicationXref
id: 9199292
author: Dynlacht, BD
author: Sánchez, I
author: Woo, MS
db: Pubmed
title: p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
source: Mol Cell Biol 17:3566-79
year: 1997

UnificationXref18620
type: UnificationXref
id: REACT_174129
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_174129.3

UnificationXref18622
type: UnificationXref
id: 5636035
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636035

UnificationXref18621
type: UnificationXref
id: 5636034
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636034

UnificationXref18624
type: UnificationXref
id: 5636037
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636037

UnificationXref18623
type: UnificationXref
id: 5636036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636036

UnificationXref18626
type: UnificationXref
id: 5636004
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636004

UnificationXref18625
type: UnificationXref
id: REACT_250795
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250795.1

UnificationXref18628
type: UnificationXref
id: 5636006
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636006

UnificationXref18627
type: UnificationXref
id: 5636005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636005

UnificationXref18629
type: UnificationXref
id: 5636007
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636007

UnificationXref18660
type: UnificationXref
id: 5636050
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636050

UnificationXref18658
type: UnificationXref
id: 5636049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636049

UnificationXref18659
type: UnificationXref
id: Q20347
db: UniProt

UnificationXref18656
type: UnificationXref
id: 5636048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636048

UnificationXref18657
type: UnificationXref
id: O01706
db: UniProt

UnificationXref18654
type: UnificationXref
id: REACT_238875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238875.1

UnificationXref18655
type: UnificationXref
id: Q23326
db: UniProt

UnificationXref18652
type: UnificationXref
id: 5636019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636019

UnificationXref18653
type: UnificationXref
id: 5636021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636021

UnificationXref18650
type: UnificationXref
id: 5636017
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636017

UnificationXref18651
type: UnificationXref
id: 5636018
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636018

UnificationXref18647
type: UnificationXref
id: 5636014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636014

UnificationXref18648
type: UnificationXref
id: 5636015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636015

UnificationXref18649
type: UnificationXref
id: 5636016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636016

UnificationXref18643
type: UnificationXref
id: 5636043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636043

UnificationXref18644
type: UnificationXref
id: REACT_256619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256619.1

UnificationXref18645
type: UnificationXref
id: 5636012
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636012

UnificationXref18646
type: UnificationXref
id: 5636013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636013

UnificationXref18640
type: UnificationXref
id: 5627759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5627759

UnificationXref18641
type: UnificationXref
id: 5627760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5627760

UnificationXref18642
type: UnificationXref
id: 5636011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636011

UnificationXref18682
type: UnificationXref
id: Q21307
db: UniProt

UnificationXref18681
type: UnificationXref
id: 5625032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625032

UnificationXref18680
type: UnificationXref
id: G5EDT6
db: UniProt

UnificationXref18674
type: UnificationXref
id: 5625021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625021

UnificationXref18675
type: UnificationXref
id: 5625022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625022

UnificationXref18672
type: UnificationXref
id: 5625019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625019

UnificationXref18673
type: UnificationXref
id: 5625020
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625020

UnificationXref18678
type: UnificationXref
id: 5625025
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625025

UnificationXref18679
type: UnificationXref
id: 5625026
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625026

UnificationXref18676
type: UnificationXref
id: 5625023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625023

UnificationXref18677
type: UnificationXref
id: 5625024
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625024

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, Jung-Ja P
author: Wang, M
author: Paschke, R
author: Fu, Zhuji
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

UnificationXref18671
type: UnificationXref
id: Q8WQG9
db: UniProt

UnificationXref18670
type: UnificationXref
id: REACT_221637
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221637.2

http://identifiers.org/pubmed/12474228
type: PublicationXref
id: 12474228
author: Niggli, Felix
author: Stallmach, Thomas
author: Koesters, Robert
author: von Knebel Doeberitz, Magnus
db: Pubmed
title: Nuclear accumulation of beta-catenin protein in Wilms' tumours
source: J. Pathol. 199:68-76
year: 2003

UnificationXref18669
type: UnificationXref
id: 5649810
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649810

UnificationXref18661
type: UnificationXref
id: Q8MPS3
db: UniProt

UnificationXref18662
type: UnificationXref
id: 5636051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636051

UnificationXref18663
type: UnificationXref
id: 5636052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636052

UnificationXref18664
type: UnificationXref
id: 5625049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625049

UnificationXref18665
type: UnificationXref
id: 5625055
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625055

UnificationXref18666
type: UnificationXref
id: 5625061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625061

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

UnificationXref18667
type: UnificationXref
id: 5625065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625065

UnificationXref18668
type: UnificationXref
id: 5625066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625066

http://identifiers.org/pubmed/1552170
type: PublicationXref
id: 1552170
author: Zabel, B
author: Mundlos, S
author: Reichert, T
author: Schwahn, B
db: Pubmed
title: Distribution of osteonectin mRNA and protein during human embryonic and fetal development
source: J. Histochem. Cytochem. 40:283-91
year: 1992

http://identifiers.org/pubmed/9548721
type: PublicationXref
id: 9548721
author: Funakoshi, T
author: Terada, S
author: Harada, A
author: Hirokawa, N
author: Yonekawa, Y
author: Takei, Y
author: Kanai, Y
author: Noda, T
author: Okada, Y
db: Pubmed
title: Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice
source: J Cell Biol 141:431-41
year: 1998

http://identifiers.org/pubmed/8128219
type: PublicationXref
id: 8128219
author: Tonks, N K
author: Flint, A J
author: Barford, D
db: Pubmed
title: Crystal structure of human protein tyrosine phosphatase 1B
source: Science 263:1397-404
year: 1994

UniProt:H2L0M0
type: ProteinReference
xref: UnificationXref6296
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

UniProt:H2L0P1
type: ProteinReference
xref: UnificationXref27651
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0P0
type: ProteinReference
xref: UnificationXref5598
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12196118
type: PublicationXref
id: 12196118
author: Holbrook, J
author: Jupe, Steve
author: Foord, SM
db: Pubmed
title: Bioinformatics and type II G-protein-coupled receptors
source: Biochem Soc Trans 30:473-9
year: 2002

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

UniProt:H2L0R5
type: ProteinReference
xref: UnificationXref25165
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0R4
type: ProteinReference
xref: UnificationXref25167
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0R2
type: ProteinReference
xref: UnificationXref26672
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0Q6
type: ProteinReference
xref: UnificationXref513
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/7060561
type: PublicationXref
id: 7060561
author: Dutilh, CE
author: Dijkman, R
author: De Haas, GH
author: Figarella, C
author: van der Ouderaa, F
author: Grataroli, R
db: Pubmed
title: Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region
source: Eur J Biochem 122:111-7
year: 1982

UniProt:H2L0Q3
type: ProteinReference
xref: UnificationXref15506
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/21307119
type: PublicationXref
id: 21307119
author: Kim, Soo-Hyun
author: Guimond, Scott
author: Turnbull, Jeremy
db: Pubmed
title: Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
source: J. Endocrinol. 209:139-51
year: 2011

http://identifiers.org/pubmed/12640123
type: PublicationXref
id: 12640123
author: Geha, Raif S
author: Kettner, Alexander
author: Falet, Hervé
author: Lee, Jeng-Shin
author: Pivniouk, Vadim
author: Mulligan, Richard
author: Kumar, Lalit
db: Pubmed
title: Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells
source: Mol. Cell. Biol. 23:2395-406
year: 2003

Depolymerisation of the Nuclear Lamina
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction116
pathway component: BiochemicalReaction115
pathway component: BiochemicalReaction114
pathway component: BiochemicalReaction113
evidence: Evidence186
xref: UnificationXref1698
xref: UnificationXref1699
pathway order: PathwayStep181
pathway order: PathwayStep182
pathway order: PathwayStep183
pathway order: PathwayStep184
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0I6
type: ProteinReference
xref: UnificationXref5591
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0I5
type: ProteinReference
xref: UnificationXref5595
organism: http://identifiers.org/taxonomy/6239

Endogenous sterols
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction870
pathway component: BiochemicalReaction1343
pathway component: BiochemicalReaction1342
pathway component: BiochemicalReaction868
evidence: Evidence1841
xref: UnificationXref13586
xref: UnificationXref13585
xref: RelationshipXref1533
pathway order: PathwayStep1832
pathway order: PathwayStep1831
pathway order: PathwayStep1243
pathway order: PathwayStep1246
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0I1
type: ProteinReference
xref: UnificationXref30912
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

UniProt:H2L0J1
type: ProteinReference
xref: UnificationXref17882
organism: http://identifiers.org/taxonomy/6239

UniProt:Q3S1I8
type: ProteinReference
name: F25H5.3
xref: UnificationXref5264
organism: http://identifiers.org/taxonomy/6239

lim-9
type: ProteinReference
name: UniProt:Q3S1I9
xref: UnificationXref8548
organism: http://identifiers.org/taxonomy/6239

PLC-mediated hydrolysis of PIP2
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction2544
evidence: Evidence3783
xref: UnificationXref31197
xref: UnificationXref31196
pathway order: PathwayStep3686
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UniProt:Q3S1J5
type: ProteinReference
name: uba-1
xref: UnificationXref25687
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0H6
type: ProteinReference
xref: UnificationXref1709
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0H5
type: ProteinReference
xref: UnificationXref1713
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/11278283
type: PublicationXref
id: 11278283
author: Tsubuki, S
author: Lee, KK
author: Yajima, N
author: Ohyama, T
author: Yonehara, S
db: Pubmed
title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
source: J Biol Chem 276:19276-85
year: 2001

UniProt:H2L0E6
type: ProteinReference
xref: UnificationXref16310
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0E5
type: ProteinReference
xref: UnificationXref16314
organism: http://identifiers.org/taxonomy/6239

mrp-1
type: ProteinReference
name: UniProt:Q3S1M2
xref: UnificationXref6214
organism: http://identifiers.org/taxonomy/6239

UnificationXref18396
type: UnificationXref
id: E04A4.7.3
db: Ensembl

UnificationXref18395
type: UnificationXref
id: REACT_243099
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243099.1

UnificationXref18394
type: UnificationXref
id: 5650489
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650489

col-7
type: ProteinReference
name: UniProt:P18832
xref: UnificationXref26312
organism: http://identifiers.org/taxonomy/6239

UnificationXref18393
type: UnificationXref
id: 5650487
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650487

UnificationXref18392
type: UnificationXref
id: 5650486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650486

UnificationXref18391
type: UnificationXref
id: 5650485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650485

UnificationXref18390
type: UnificationXref
id: P30635
db: UniProt

UnificationXref18388
type: UnificationXref
id: 5650481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650481

UnificationXref18389
type: UnificationXref
id: REACT_177298
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177298.3

UniProt:H2L0C4
type: ProteinReference
xref: UnificationXref15956
organism: http://identifiers.org/taxonomy/6239

UnificationXref18386
type: UnificationXref
id: 5650478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650478

UnificationXref18387
type: UnificationXref
id: 5650479
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650479

UniProt:H2L0C7
type: ProteinReference
xref: UnificationXref26564
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/22798961
type: PublicationXref
id: 22798961
author: Wang, Xiaohong
author: Li, Ju-Pi
author: Chuang, Huai-Chia
author: Tan, Tse-Hua
db: Pubmed
title: Regulation of PKC-? function by phosphorylation in T cell receptor signaling
source: Front Immunol 3:197
year: 2012

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

NGF signalling via TRKA from the plasma membrane
type: Pathway
data source: Provenance1
pathway component: REACT 239393.1
pathway component: REACT 240147.1
pathway component: REACT 210621.2
pathway component: REACT 254102.1
pathway component: REACT 249086.1
pathway component: REACT 251967.1
pathway component: REACT 255128.1
evidence: Evidence2978
xref: UnificationXref23296
xref: UnificationXref23297
pathway order: PathwayStep2931
pathway order: PathwayStep2932
pathway order: PathwayStep2934
pathway order: PathwayStep2953
pathway order: PathwayStep2937
pathway order: PathwayStep2939
pathway order: PathwayStep2914
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0D1
type: ProteinReference
xref: UnificationXref19460
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0D0
type: ProteinReference
xref: UnificationXref19458
organism: http://identifiers.org/taxonomy/6239

UnificationXref18397
type: UnificationXref
id: 5624687
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624687

http://identifiers.org/pubmed/17597991
type: PublicationXref
id: 17597991
author: Ruggeri, ZM
db: Pubmed
title: Von Willebrand factor: looking back and looking forward
source: Thromb Haemost 98:55-62
year: 2007

UnificationXref18398
type: UnificationXref
id: E04A4.7.1
db: Ensembl

UnificationXref18399
type: UnificationXref
id: 5624688
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624688

http://identifiers.org/pubmed/11278251
type: PublicationXref
id: 11278251
author: Murakami, G
author: Imamura, T
author: Tanaka, K
author: Fukuchi, M
author: Ebisawa, T
author: Miyazono, K
author: Chiba, T
db: Pubmed
title: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
source: J Biol Chem 276:12477-80
year: 2001

http://identifiers.org/pubmed/10892742
type: PublicationXref
id: 10892742
author: Kidd, T
author: Bashaw, GJ
author: Murray, D
author: Pawson, T
author: Goodman, CS
db: Pubmed
title: Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
source: Cell 101:703-15
year: 2000

UnificationXref18370
type: UnificationXref
id: Q93204
db: UniProt

http://identifiers.org/pubmed/19487573
type: PublicationXref
id: 19487573
author: Agami, Reuven
author: Rouhanifard, Sara H
author: Holland, Eric C
author: Tuschl, Thomas
author: Huse, Jason T
author: Hambardzumyan, Dolores
author: Brennan, Cameron
author: Sohn-Lee, Cherin
author: le Sage, Carlos
author: Wee, Boyoung
author: Pena, John
db: Pubmed
title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
source: Genes Dev. 23:1327-37
year: 2009

UnificationXref18374
type: UnificationXref
id: 5650554
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650554

UnificationXref18373
type: UnificationXref
id: Q9N2X2
db: UniProt

UnificationXref18372
type: UnificationXref
id: 5650549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650549

UnificationXref18371
type: UnificationXref
id: MOD:00031
db: MOD

UniProt:H2L0A0
type: ProteinReference
xref: UnificationXref30623
organism: http://identifiers.org/taxonomy/6239

UnificationXref18366
type: UnificationXref
id: 5650496
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650496

UniProt:H2L0A1
type: ProteinReference
xref: UnificationXref30621
organism: http://identifiers.org/taxonomy/6239

UnificationXref18367
type: UnificationXref
id: REACT_177505
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177505.3

UnificationXref18364
type: UnificationXref
id: 5650493
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650493

UnificationXref18365
type: UnificationXref
id: 5650494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650494

UnificationXref18368
type: UnificationXref
id: 3341331
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3341331

UnificationXref18369
type: UnificationXref
id: REACT_173243
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173243.1

UnificationXref18381
type: UnificationXref
id: Q17424
db: UniProt

UnificationXref18380
type: UnificationXref
id: REACT_236615
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_236615.1

UnificationXref18383
type: UnificationXref
id: 5650473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650473

UnificationXref18382
type: UnificationXref
id: 5650471
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650471

UnificationXref18385
type: UnificationXref
id: 5650477
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650477

UnificationXref18384
type: UnificationXref
id: Q21824
db: UniProt

UnificationXref18375
type: UnificationXref
id: Q95003
db: UniProt

UniProt:H2L0B4
type: ProteinReference
xref: UnificationXref31527
organism: http://identifiers.org/taxonomy/6239

UnificationXref18376
type: UnificationXref
id: 5650559
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650559

UnificationXref18377
type: UnificationXref
id: 5650560
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650560

UnificationXref18378
type: UnificationXref
id: 5650561
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650561

UnificationXref18379
type: UnificationXref
id: 5650563
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650563

UniProt:H2L0B9
type: ProteinReference
xref: UnificationXref639
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L0B7
type: ProteinReference
xref: UnificationXref10466
organism: http://identifiers.org/taxonomy/6239

UnificationXref18351
type: UnificationXref
id: 5650765
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650765

UnificationXref18352
type: UnificationXref
id: 5650766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650766

UniProt:P24348
type: ProteinReference
name: let-23
xref: UnificationXref2102
organism: http://identifiers.org/taxonomy/6239

UnificationXref18350
type: UnificationXref
id: 5650764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650764

UnificationXref18349
type: UnificationXref
id: 5650763
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650763

UnificationXref18348
type: UnificationXref
id: 5650762
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650762

UnificationXref18347
type: UnificationXref
id: 5650761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650761

UnificationXref18346
type: UnificationXref
id: REACT_214385
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_214385.2

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

UnificationXref18345
type: UnificationXref
id: 5650147
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650147

UnificationXref18344
type: UnificationXref
id: REACT_17651
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17651.2

UnificationXref18343
type: UnificationXref
id: 352327
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352327

UnificationXref18342
type: UnificationXref
id: REACT_173456
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173456.1

UnificationXref18360
type: UnificationXref
id: REACT_117659
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117659.1

http://identifiers.org/pubmed/15585596
type: PublicationXref
id: 15585596
author: Berggren, PO
author: Yang, SN
db: Pubmed
title: Beta-cell CaV channel regulation in physiology and pathophysiology
source: Am J Physiol Endocrinol Metab 288:E16-28
year: 2005

UnificationXref18361
type: UnificationXref
id: 5650490
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650490

UnificationXref18362
type: UnificationXref
id: 5650491
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650491

UnificationXref18363
type: UnificationXref
id: 5650492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650492

UnificationXref18358
type: UnificationXref
id: REACT_117738
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117738.1

UnificationXref18357
type: UnificationXref
id: 1655882
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655882

UnificationXref18359
type: UnificationXref
id: 1655887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655887

UnificationXref18354
type: UnificationXref
id: 5650768
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650768

UnificationXref18353
type: UnificationXref
id: 5650767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650767

UnificationXref18356
type: UnificationXref
id: REACT_177561
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_177561.3

UnificationXref18355
type: UnificationXref
id: 5650770
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650770

UnificationXref18330
type: UnificationXref
id: 3299683
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3299683

UnificationXref18329
type: UnificationXref
id: REACT_236565
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_236565.1

UnificationXref18328
type: UnificationXref
id: 5650760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650760

Lysosome Vesicle Biogenesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction17
evidence: Evidence23
xref: UnificationXref250
xref: UnificationXref251
pathway order: PathwayStep22
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref18323
type: UnificationXref
id: REACT_173244
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173244.2

UnificationXref18322
type: UnificationXref
id: 3341308
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3341308

UnificationXref18321
type: UnificationXref
id: REACT_249584
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249584.1

UnificationXref18320
type: UnificationXref
id: 5650153
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650153

UnificationXref18327
type: UnificationXref
id: REACT_9648
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9648.2

UnificationXref18326
type: UnificationXref
id: 189461
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189461

UnificationXref18325
type: UnificationXref
id: REACT_9751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9751.1

UnificationXref18324
type: UnificationXref
id: 189481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189481

http://identifiers.org/pubmed/7938165
type: PublicationXref
id: 7938165
author: Martin, GR
author: Humphrey, PP
author: Saxena, PR
author: Fozard, JR
author: Mylecharane, EJ
author: Clarke, DE
author: Hartig, PR
author: Hoyer, D
db: Pubmed
title: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
source: Pharmacol Rev 46:157-203
year: 1994

UnificationXref18340
type: UnificationXref
id: REACT_176837
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176837.3

UnificationXref18341
type: UnificationXref
id: 3299686
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3299686

http://identifiers.org/pubmed/7938162
type: PublicationXref
id: 7938162
author: Lefkowitz, RJ
author: Hieble, JP
author: Molinoff, PB
author: Minneman, KP
author: Trendelenburg, U
author: Langer, SZ
author: Bylund, DB
author: Ruffolo RR, Jr
author: Eikenberg, DC
db: Pubmed
title: International Union of Pharmacology nomenclature of adrenoceptors
source: Pharmacol Rev 46:121-36
year: 1994

UnificationXref18339
type: UnificationXref
id: 5650137
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650137

UnificationXref18332
type: UnificationXref
id: P31161
db: UniProt

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

UnificationXref18331
type: UnificationXref
id: REACT_173459
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173459.1

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

UnificationXref18334
type: UnificationXref
id: P41977
db: UniProt

UnificationXref18333
type: UnificationXref
id: 5650128
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650128

UnificationXref18336
type: UnificationXref
id: 5650133
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650133

UnificationXref18335
type: UnificationXref
id: 5650132
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650132

UnificationXref18338
type: UnificationXref
id: 5650135
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650135

http://identifiers.org/pubmed/8244992
type: PublicationXref
id: 8244992
author: Gerriets, JE
author: Curwin, SL
author: Last, JA
db: Pubmed
title: Tendon hypertrophy is associated with increased hydroxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen
source: J Biol Chem 268:25553-60
year: 1993

UnificationXref18337
type: UnificationXref
id: 5650134
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650134

UnificationXref18311
type: UnificationXref
id: 5651584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651584

UnificationXref18312
type: UnificationXref
id: 5651585
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651585

UnificationXref18310
type: UnificationXref
id: 5650693
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650693

UnificationXref18315
type: UnificationXref
id: 5650143
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650143

UnificationXref18316
type: UnificationXref
id: 5650144
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650144

UnificationXref18313
type: UnificationXref
id: 5650141
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650141

UnificationXref18314
type: UnificationXref
id: 5650142
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650142

UnificationXref18319
type: UnificationXref
id: REACT_226366
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_226366.2

UnificationXref18317
type: UnificationXref
id: 5650145
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650145

UnificationXref18318
type: UnificationXref
id: 5651586
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651586

UnificationXref18300
type: UnificationXref
id: 3777113
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3777113

UnificationXref18301
type: UnificationXref
id: REACT_173283
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173283.1

UnificationXref18302
type: UnificationXref
id: 5650756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650756

UnificationXref18303
type: UnificationXref
id: 5650757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650757

UnificationXref18304
type: UnificationXref
id: 5650758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650758

UnificationXref18305
type: UnificationXref
id: 5650778
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650778

UnificationXref18306
type: UnificationXref
id: 5650779
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650779

UnificationXref18307
type: UnificationXref
id: 5650780
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650780

UnificationXref18308
type: UnificationXref
id: REACT_243997
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243997.1

UnificationXref18309
type: UnificationXref
id: G5ECR5
db: UniProt

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

http://identifiers.org/pubmed/7925341
type: PublicationXref
id: 7925341
author: Bandoh, S
author: Takeda, O
author: Takahashi, E
author: Tanabe, T
author: Ihara, H
author: Miyata, A
author: Yokoyama, C
db: Pubmed
title: Characterization of the human gene (TBXAS1) encoding thromboxane synthase
source: Eur J Biochem 224:273-9
year: 1994

UniProt:H2L099
type: ProteinReference
xref: UnificationXref30617
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L085
type: ProteinReference
xref: UnificationXref21952
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

UniProt:H2L082
type: ProteinReference
xref: UnificationXref23782
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

http://identifiers.org/pubmed/12147242
type: PublicationXref
id: 12147242
author: Maekawa, M
author: Aoyagi, K
author: Yoshida, T
author: Matsukura, N
author: Tanabe, C
author: Sasaki, H
author: Terada, M
author: Ishizuka, T
author: Tajiri, T
author: Tokunaga, A
author: Sakamoto, H
db: Pubmed
title: Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH
source: Biochem Biophys Res Commun 296:152-5
year: 2002

http://identifiers.org/pubmed/9883880
type: PublicationXref
id: 9883880
author: Callebaut, I
author: Dehoux, P
author: Cossart, P
db: Pubmed
title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
source: FEBS Lett 441:181-5
year: 1998

UniProt:H2L060
type: ProteinReference
xref: UnificationXref4565
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

UniProt:H2L053
type: ProteinReference
xref: UnificationXref31333
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L055
type: ProteinReference
xref: UnificationXref25475
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

UniProt:H2L039
type: ProteinReference
xref: UnificationXref3713
organism: http://identifiers.org/taxonomy/6239

nhr-88
type: ProteinReference
name: UniProt:Q9GTC9
xref: UnificationXref27260
organism: http://identifiers.org/taxonomy/6239

UniProt:H2L023
type: ProteinReference
xref: UnificationXref26647
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/8647866
type: PublicationXref
id: 8647866
author: Kozasa, T
author: Gilman, AG
db: Pubmed
title: Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma
source: J Biol Chem 271:12562-7
year: 1996

http://identifiers.org/pubmed/14614009
type: PublicationXref
id: 14614009
author: Bartlett, JM
author: Krishna, NS
author: Witton, CJ
author: Edwards, J
db: Pubmed
title: Gene amplifications associated with the development of hormone-resistant prostate cancer
source: Clin Cancer Res 9:5271-81
year: 2003

UniProt:H2L002
type: ProteinReference
xref: UnificationXref4686
organism: http://identifiers.org/taxonomy/6239

nhr-46
type: ProteinReference
name: UniProt:Q9GTH0
xref: UnificationXref27284
organism: http://identifiers.org/taxonomy/6239

nhr-46
type: ProteinReference
name: UniProt:Q9GTH2
xref: UnificationXref27310
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

chromosome, centromeric region
type: CellularLocationVocabulary
xref: UnificationXref1847

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

CHEBI:443041
type: SmallMoleculeReference
name: CHEBI:443041 [ChEBI:443041]
xref: UnificationXref3230

UniProt:Q9GTG9
type: ProteinReference
name: nhr-46
xref: UnificationXref27276
organism: http://identifiers.org/taxonomy/6239

nhr-46
type: ProteinReference
name: UniProt:Q9GTG8
xref: UnificationXref27250
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/3624221
type: PublicationXref
id: 3624221
author: Mechanic, GL
author: Yamauchi, M
author: Hashimoto, F
author: London, RE
author: Guenat, C
db: Pubmed
title: Structure and formation of a stable histidine-based trifunctional cross-link in skin collagen
source: J Biol Chem 262:11428-34
year: 1987

http://identifiers.org/pubmed/11851336
type: PublicationXref
id: 11851336
author: Swain, A
author: Dunten, P
author: Crowther, R
author: Kammlott, U
author: Wertheimer, SJ
author: Michel, H
author: Weber, D
author: Ramsey, GB
author: Levin, W
author: Belunis, C
author: Hollfelder, K
db: Pubmed
title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
source: J Mol Biol 316:257-264
year: 2002

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

http://identifiers.org/pubmed/22110128
type: PublicationXref
id: 22110128
author: Sharma, Manisha
author: Johnson, Michael
author: Henderson, Beric R
author: Jamieson, Cara
author: Molloy, Mark P
db: Pubmed
title: Specific armadillo repeat sequences facilitate ?-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358
source: J. Biol. Chem. 287:819-31
year: 2012

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

http://identifiers.org/pubmed/19073728
type: PublicationXref
id: 19073728
author: Lenschow, DJ
author: Virgin, HW
author: Giannakopoulos, NV
author: Lai, C
author: Haas, AL
author: Arutyunova, E
db: Pubmed
title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
source: J Virol 83:1602-10
year: 2009

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

C30C11.4
type: ProteinReference
name: UniProt:Q05036
xref: UnificationXref31229
organism: http://identifiers.org/taxonomy/6239

SUMO is transferred from E1 to E2 (UBE2I, UBC9)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1951
evidence: Evidence2726
xref: RelationshipXref2194
xref: UnificationXref21898
xref: UnificationXref21899
pathway order: PathwayStep2704
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

http://identifiers.org/pubmed/12151385
type: PublicationXref
id: 12151385
author: Shimanuki, T
author: Murakami, G
author: Imamura, T
author: Shikauchi, Y
author: Fukuchi, M
author: Suzuki, C
author: Miyazono, K
db: Pubmed
title: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane
source: J Biol Chem 277:39919-25
year: 2002

UnificationXref18491
type: UnificationXref
id: 5651640
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651640

UnificationXref18490
type: UnificationXref
id: 5651639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651639

UnificationXref18495
type: UnificationXref
id: REACT_237761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237761.1

UnificationXref18494
type: UnificationXref
id: 5651642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651642

http://identifiers.org/pubmed/11533026
type: PublicationXref
id: 11533026
author: Culotti, J
author: Killeen, M
author: Binns, KL
author: Tong, J
author: Pawson, T
author: Steven, R
db: Pubmed
title: Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain
source: J Biol Chem 276:40917-25
year: 2001

UnificationXref18493
type: UnificationXref
id: 5651641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651641

UnificationXref18492
type: UnificationXref
id: 5651619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651619

UnificationXref18487
type: UnificationXref
id: 5651602
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651602

UnificationXref18488
type: UnificationXref
id: 5651638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651638

UnificationXref18485
type: UnificationXref
id: REACT_222845
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222845.2

UnificationXref18486
type: UnificationXref
id: 5651637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651637

UnificationXref18489
type: UnificationXref
id: 5651603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651603

cdc-42
type: ProteinReference
name: UniProt:Q05062
xref: UnificationXref2740
organism: http://identifiers.org/taxonomy/6239

UnificationXref18496
type: UnificationXref
id: 5651620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651620

UnificationXref18497
type: UnificationXref
id: REACT_222960
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222960.2

UnificationXref18498
type: UnificationXref
id: 5653537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653537

UnificationXref18499
type: UnificationXref
id: REACT_220279
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220279.2

http://identifiers.org/pubmed/16271386
type: PublicationXref
id: 16271386
author: Tomari, Y
author: Bartel, DP
author: Zamore, Phillip D
author: Shin, C
author: Matranga, C
db: Pubmed
title: Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
source: Cell 123:607-20
year: 2005

http://identifiers.org/pubmed/15005656
type: PublicationXref
id: 15005656
author: Väisänen, Marja-Riitta
author: Väisänen, Timo
author: Pihlajaniemi, Taina
db: Pubmed
title: The shed ectodomain of type XIII collagen affects cell behaviour in a matrix-dependent manner
source: Biochem. J. 380:685-93
year: 2004

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

UnificationXref18450
type: UnificationXref
id: 5650570
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650570

UnificationXref18451
type: UnificationXref
id: REACT_232008
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232008.1

UnificationXref18444
type: UnificationXref
id: 5650527
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650527

UnificationXref18443
type: UnificationXref
id: 5650511
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650511

UnificationXref18442
type: UnificationXref
id: Q7YTU4
db: UniProt

UnificationXref18441
type: UnificationXref
id: 5650526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650526

UnificationXref18448
type: UnificationXref
id: 5650567
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650567

UnificationXref18447
type: UnificationXref
id: Q8MXT1
db: UniProt

UnificationXref18446
type: UnificationXref
id: REACT_238749
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238749.1

UnificationXref18445
type: UnificationXref
id: 5650529
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650529

UnificationXref18449
type: UnificationXref
id: 5650568
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650568

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

UnificationXref18460
type: UnificationXref
id: 5650645
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650645

UnificationXref18461
type: UnificationXref
id: REACT_232381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232381.1

UnificationXref18462
type: UnificationXref
id: P54812
db: UniProt

UnificationXref18453
type: UnificationXref
id: REACT_184548
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184548.3

UnificationXref18452
type: UnificationXref
id: 5652558
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652558

UnificationXref18455
type: UnificationXref
id: 5650596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650596

UnificationXref18454
type: UnificationXref
id: G5EFT5
db: UniProt

UnificationXref18457
type: UnificationXref
id: 5650642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650642

UnificationXref18456
type: UnificationXref
id: 5633431
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633431

UnificationXref18459
type: UnificationXref
id: 5650644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650644

UnificationXref18458
type: UnificationXref
id: 5650643
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650643

UnificationXref18472
type: UnificationXref
id: 5652289
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652289

UnificationXref18473
type: UnificationXref
id: 5652291
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652291

UnificationXref18470
type: UnificationXref
id: 5324631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5324631

UnificationXref18471
type: UnificationXref
id: REACT_201413
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201413.1

UnificationXref18469
type: UnificationXref
id: 5652288
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652288

UnificationXref18468
type: UnificationXref
id: 5652278
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652278

UnificationXref18467
type: UnificationXref
id: Q9U266
db: UniProt

UnificationXref18466
type: UnificationXref
id: 5652287
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652287

UnificationXref18465
type: UnificationXref
id: 5652286
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652286

UnificationXref18464
type: UnificationXref
id: P54811
db: UniProt

UnificationXref18463
type: UnificationXref
id: 5652282
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652282

http://identifiers.org/pubmed/21413788
type: PublicationXref
id: 21413788
author: Dunaway-Mariano, Debra
author: Wu, Rui
author: Garland, Megan
author: Allen, Karen N
db: Pubmed
title: Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1
source: Biochemistry 50:3045-7
year: 2011

UnificationXref18481
type: UnificationXref
id: 5624540
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624540

UnificationXref18482
type: UnificationXref
id: 5650618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650618

UnificationXref18483
type: UnificationXref
id: 5650619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650619

UnificationXref18484
type: UnificationXref
id: 5650627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650627

UnificationXref18480
type: UnificationXref
id: P53013
db: UniProt

UnificationXref18479
type: UnificationXref
id: 5650647
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650647

UnificationXref18478
type: UnificationXref
id: REACT_209716
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209716.2

UnificationXref18475
type: UnificationXref
id: 5650625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650625

UnificationXref18474
type: UnificationXref
id: REACT_244196
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244196.1

UnificationXref18477
type: UnificationXref
id: 5650646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650646

UnificationXref18476
type: UnificationXref
id: 5650626
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650626

UnificationXref18418
type: UnificationXref
id: 5650537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650537

UnificationXref18419
type: UnificationXref
id: 5650538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650538

UnificationXref18416
type: UnificationXref
id: 5650535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650535

UnificationXref18417
type: UnificationXref
id: 5650536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650536

UnificationXref18414
type: UnificationXref
id: 5650533
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650533

UnificationXref18415
type: UnificationXref
id: Q8IG31
db: UniProt

UnificationXref18412
type: UnificationXref
id: REACT_218521
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_218521.2

UnificationXref18413
type: UnificationXref
id: H2KZL7
db: UniProt

UnificationXref18410
type: UnificationXref
id: 5624691
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624691

UnificationXref18411
type: UnificationXref
id: 5650505
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650505

UnificationXref18409
type: UnificationXref
id: REACT_165067
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_165067.1

UnificationXref18405
type: UnificationXref
id: REACT_164233
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_164233.1

UnificationXref18406
type: UnificationXref
id: 5624692
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624692

UnificationXref18407
type: UnificationXref
id: CHEBI:38573
db: ChEBI

UnificationXref18408
type: UnificationXref
id: 3341317
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3341317

UnificationXref18401
type: UnificationXref
id: 5624689
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624689

UnificationXref18402
type: UnificationXref
id: 5624690
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624690

UnificationXref18403
type: UnificationXref
id: CHEBI:38574
db: ChEBI

UnificationXref18404
type: UnificationXref
id: 3341371
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3341371

http://identifiers.org/pubmed/9659899
type: PublicationXref
id: 9659899
author: Vogel, W
author: Gish, G D
author: Pawson, T
author: Alves, F
db: Pubmed
title: The discoidin domain receptor tyrosine kinases are activated by collagen
source: Mol. Cell 1:13-23
year: 1997

UnificationXref18400
type: UnificationXref
id: E04A4.7.2
db: Ensembl

UniProt:Q9BMN8
type: ProteinReference
xref: UnificationXref29655
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

http://identifiers.org/pubmed/18331591
type: PublicationXref
id: 18331591
author: Foster, LJ
author: Rogers, LD
db: Pubmed
title: Contributions of proteomics to understanding phagosome maturation
source: Cell Microbiol 10:1405-12
year: 2008

UniProt:Q9GUM2
type: ProteinReference
name: bre-4
xref: UnificationXref21801
organism: http://identifiers.org/taxonomy/6239

UnificationXref18438
type: UnificationXref
id: H2KYJ6
db: UniProt

UnificationXref18439
type: UnificationXref
id: 5650524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650524

UnificationXref18432
type: UnificationXref
id: 5650515
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650515

UnificationXref18433
type: UnificationXref
id: A8WFK7
db: UniProt

UnificationXref18430
type: UnificationXref
id: 5650507
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650507

UnificationXref18431
type: UnificationXref
id: A8WFK6
db: UniProt

UnificationXref18436
type: UnificationXref
id: O45183
db: UniProt

UnificationXref18437
type: UnificationXref
id: 5650522
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650522

UnificationXref18434
type: UnificationXref
id: 5650517
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650517

UnificationXref18435
type: UnificationXref
id: 5650518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650518

UniProt:Q9BMK8
type: ProteinReference
name: clh-4
xref: UnificationXref17880
organism: http://identifiers.org/taxonomy/6239

UnificationXref18440
type: UnificationXref
id: 5650525
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650525

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

UniProt:Q9BMK9
type: ProteinReference
name: clh-3
xref: UnificationXref17875
organism: http://identifiers.org/taxonomy/6239

UnificationXref18427
type: UnificationXref
id: 5642217
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5642217

UnificationXref18428
type: UnificationXref
id: 3341383
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3341383

UnificationXref18429
type: UnificationXref
id: REACT_173253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173253.1

UnificationXref18420
type: UnificationXref
id: 5650539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650539

UnificationXref18421
type: UnificationXref
id: 5650540
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650540

UnificationXref18422
type: UnificationXref
id: 5650541
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650541

UnificationXref18423
type: UnificationXref
id: 5650542
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650542

UnificationXref18424
type: UnificationXref
id: 5650544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650544

UnificationXref18425
type: UnificationXref
id: REACT_215194
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_215194.2

UnificationXref18426
type: UnificationXref
id: Q17770
db: UniProt

http://identifiers.org/pubmed/10681536
type: PublicationXref
id: 10681536
author: Gaither, LA
author: Eide, DJ
db: Pubmed
title: Functional expression of the human hZIP2 zinc transporter
source: J Biol Chem 275:5560-4
year: 2000

http://identifiers.org/pubmed/18367721
type: PublicationXref
id: 18367721
author: Skinner, SJ
author: Deleault, KM
author: Whitfield, ML
author: Brooks, SA
author: Gross, RH
author: Townley-Tilson, WH
author: Emmons, J
db: Pubmed
title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
source: RNA 14:888-902
year: 2008

http://identifiers.org/pubmed/12782243
type: PublicationXref
id: 12782243
author: Prézeau, L
author: Galvez, T
author: Pin, JP
db: Pubmed
title: Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
source: Pharmacol Ther 98:325-54
year: 2003

http://identifiers.org/pubmed/10681567
type: PublicationXref
id: 10681567
author: Suzuki, N
author: Higashino, K
author: Ikeda, M
author: Hanasaki, K
author: Kawamoto, K
author: Ishizaki, J
author: Ono, T
author: Yokota, Y
author: Fujii, N
db: Pubmed
title: Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
source: J Biol Chem 275:5785-93
year: 2000

http://identifiers.org/pubmed/20947020
type: PublicationXref
id: 20947020
author: Harrison, Stephen C
author: Xing, Yi
author: Yu, Anan
author: Kirchhausen, Tomas
db: Pubmed
title: Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling
source: Structure 18:1311-20
year: 2010

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

http://identifiers.org/pubmed/171650
type: PublicationXref
id: 171650
author: Harper, E
author: Byers, PH
author: Click, EM
author: Bornstein, P
db: Pubmed
title: Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain
source: Proc Natl Acad Sci U S A 72:3009-13
year: 1975

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

Lipid digestion, mobilization, and transport
type: Pathway
data source: Provenance1
pathway component: REACT 252611.1
pathway component: REACT 247162.1
pathway component: REACT 249877.1
pathway component: REACT 219851.2
evidence: Evidence1047
xref: UnificationXref7900
xref: UnificationXref7901
pathway order: PathwayStep1041
pathway order: PathwayStep1031
pathway order: PathwayStep1027
pathway order: PathwayStep1036
display name: Lipid and lipoprotein metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/19781681
type: PublicationXref
id: 19781681
author: van Dijk, FS
author: Fratantoni, SA
author: Zwikstra, EH
author: Sistermans, EA
author: Pals, G
author: Nesbitt, IM
author: Verbeke, JI
author: Nikkels, PG
author: Morsman, AC
author: Cobben, JM
author: Meijers-Heijboer, H
author: van Roij, MH
author: McKeown, C
author: Piersma, SR
author: Huizer, M
author: Dalton, A
author: Högler, W
author: Elting, MW
author: Wijnaendts, LC
author: Jimenez, CR
author: Shaw, NJ
db: Pubmed
title: PPIB mutations cause severe osteogenesis imperfecta
source: Am J Hum Genet 85:521-7
year: 2009

http://identifiers.org/pubmed/12151341
type: PublicationXref
id: 12151341
author: Takamori, S
author: Malherbe, P
author: Jahn, Reinhard
author: Broger, C
db: Pubmed
title: Molecular cloning and functional characterization of human vesicular glutamate transporter 3
source: EMBO Rep 3:798-803
year: 2002

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

UniProt:H2KMJ3
type: ProteinReference
xref: UnificationXref19497
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9438378
type: PublicationXref
id: 9438378
author: Shuttleworth, CA
db: Pubmed
title: Type VIII collagen
source: Int J Biochem Cell Biol 29:1145-8
year: 1997

http://identifiers.org/pubmed/11239160
type: PublicationXref
id: 11239160
author: Poo, M
author: Stein, E
author: Tessier-Lavigne, M
author: Zou, Y
db: Pubmed
title: Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation
source: Science 291:1976-82
year: 2001

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction36
pathway component: BiochemicalReaction37
pathway component: BiochemicalReaction38
pathway component: BiochemicalReaction35
evidence: Evidence54
xref: UnificationXref829
xref: UnificationXref830
pathway order: PathwayStep50
pathway order: PathwayStep51
pathway order: PathwayStep52
pathway order: PathwayStep49
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UniProt:H2KMK5
type: ProteinReference
xref: UnificationXref24273
organism: http://identifiers.org/taxonomy/6239

UniProt:H2KMK7
type: ProteinReference
xref: UnificationXref24275
organism: http://identifiers.org/taxonomy/6239

SequenceSite19053
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19054
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19055
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19056
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19057
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18119
type: UnificationXref
id: 5650090
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650090

SequenceSite19058
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19059
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18115
type: UnificationXref
id: 5650086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650086

UnificationXref18116
type: UnificationXref
id: 5650087
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650087

UnificationXref18117
type: UnificationXref
id: 5650088
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650088

UnificationXref18118
type: UnificationXref
id: 5650089
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650089

UnificationXref18111
type: UnificationXref
id: 5650082
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650082

SequenceSite19050
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18112
type: UnificationXref
id: 5650083
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650083

http://identifiers.org/pubmed/6696726
type: PublicationXref
id: 6696726
author: Alsenz, J
author: Dierich, M P
author: Lambris, J D
author: Schulz, T F
db: Pubmed
title: Mapping of the properdin-binding site in the third component of complement
source: Biochem. J. 217:323-6
year: 1984

SequenceSite19051
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18113
type: UnificationXref
id: 5650084
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650084

SequenceSite19052
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18114
type: UnificationXref
id: 5650085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650085

UnificationXref18121
type: UnificationXref
id: 5650092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650092

UnificationXref18120
type: UnificationXref
id: 5650091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650091

SequenceSite19066
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19067
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19064
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19065
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19068
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18108
type: UnificationXref
id: 5650079
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650079

SequenceSite19069
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18109
type: UnificationXref
id: 5650080
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650080

UnificationXref18106
type: UnificationXref
id: 5650077
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650077

UnificationXref18107
type: UnificationXref
id: 5650078
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650078

UnificationXref18104
type: UnificationXref
id: 5650075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650075

UnificationXref18105
type: UnificationXref
id: 5650076
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650076

SequenceSite19062
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18102
type: UnificationXref
id: 5650073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650073

SequenceSite19063
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18103
type: UnificationXref
id: 5650074
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650074

SequenceSite19060
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18100
type: UnificationXref
id: 5650071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650071

SequenceSite19061
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18101
type: UnificationXref
id: 5650072
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650072

UnificationXref18110
type: UnificationXref
id: 5650081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650081

UniProt:P24585
type: ProteinReference
name: deg-1
xref: UnificationXref17664
organism: http://identifiers.org/taxonomy/6239

UniProt:P51875
type: ProteinReference
name: goa-1
xref: UnificationXref24523
organism: http://identifiers.org/taxonomy/6239

SequenceSite19035
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19036
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19037
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19038
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19031
type: SequenceSite
position status: EQUAL
sequence position: 108

SequenceSite19032
type: SequenceSite
position status: EQUAL
sequence position: 794

SequenceSite19033
type: SequenceSite
position status: EQUAL
sequence position: 108

SequenceSite19034
type: SequenceSite
position status: EQUAL
sequence position: 794

SequenceSite19030
type: SequenceSite
position status: EQUAL
sequence position: 488

SequenceSite19039
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19048
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19049
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19046
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19047
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19044
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19045
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19042
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19043
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19040
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19041
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19090
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18159
type: UnificationXref
id: 5639557
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639557

SequenceSite19092
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19091
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19094
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18156
type: UnificationXref
id: 5639554
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639554

SequenceSite19093
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18155
type: UnificationXref
id: G5ECV8
db: UniProt

SequenceSite19096
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18158
type: UnificationXref
id: 5639556
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639556

SequenceSite19095
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18157
type: UnificationXref
id: 5639555
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639555

SequenceSite19098
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19097
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19099
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18162
type: UnificationXref
id: 5639560
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639560

UnificationXref18163
type: UnificationXref
id: 5639561
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639561

UnificationXref18164
type: UnificationXref
id: 5639562
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639562

UnificationXref18165
type: UnificationXref
id: 5639567
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639567

UnificationXref18160
type: UnificationXref
id: 5639558
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639558

UnificationXref18161
type: UnificationXref
id: 5639559
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639559

UnificationXref18149
type: UnificationXref
id: G5EBV0
db: UniProt

UnificationXref18148
type: UnificationXref
id: 5639550
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639550

UnificationXref18147
type: UnificationXref
id: G5EE79
db: UniProt

UnificationXref18146
type: UnificationXref
id: 5639475
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639475

UnificationXref18145
type: UnificationXref
id: MOD:01024
db: MOD

UnificationXref18144
type: UnificationXref
id: 5639485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639485

http://identifiers.org/pubmed/10652353
type: PublicationXref
id: 10652353
author: Ohashi, K
author: Maekawa, M
author: Mizuno, K
author: Nagata, K
author: Narumiya, S
author: Ishizaki, T
db: Pubmed
title: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
source: J Biol Chem 275:3577-82
year: 2000

UnificationXref18153
type: UnificationXref
id: G5EEP8
db: UniProt

UnificationXref18154
type: UnificationXref
id: 5639553
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639553

UnificationXref18151
type: UnificationXref
id: Q56W01
db: UniProt

UnificationXref18152
type: UnificationXref
id: 5639552
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639552

UnificationXref18150
type: UnificationXref
id: 5639551
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639551

SequenceSite19072
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18134
type: UnificationXref
id: REACT_245769
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245769.1

SequenceSite19071
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18133
type: UnificationXref
id: 5650105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650105

SequenceSite19074
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18136
type: UnificationXref
id: REACT_198027
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_198027.3

SequenceSite19073
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18135
type: UnificationXref
id: 5653531
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653531

UnificationXref18138
type: UnificationXref
id: REACT_197702
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_197702.3

UnificationXref18137
type: UnificationXref
id: 5653506
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653506

SequenceSite19070
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18139
type: UnificationXref
id: 5653198
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653198

SequenceSite19079
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19076
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19075
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19078
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19077
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18140
type: UnificationXref
id: REACT_256467
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256467.1

UnificationXref18141
type: UnificationXref
id: 5652506
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652506

UnificationXref18142
type: UnificationXref
id: REACT_238661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238661.1

UnificationXref18143
type: UnificationXref
id: G5EGD2
db: UniProt

SequenceSite19085
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18125
type: UnificationXref
id: 5650096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650096

SequenceSite19084
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18124
type: UnificationXref
id: 5650095
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650095

SequenceSite19083
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18123
type: UnificationXref
id: 5650094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650094

SequenceSite19082
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18122
type: UnificationXref
id: 5650093
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650093

SequenceSite19081
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18129
type: UnificationXref
id: REACT_174346
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_174346.3

SequenceSite19080
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18128
type: UnificationXref
id: 5650100
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650100

UnificationXref18127
type: UnificationXref
id: 5650098
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650098

UnificationXref18126
type: UnificationXref
id: 5650097
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650097

http://identifiers.org/pubmed/11278486
type: PublicationXref
id: 11278486
author: Chong, C
author: Tan, L
author: Lim, L
author: Manser, E
db: Pubmed
title: The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
source: J Biol Chem 276:17347-53
year: 2001

SequenceSite19089
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19088
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19087
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19086
type: SequenceSite
position status: EQUAL
sequence position: 1388

UnificationXref18131
type: UnificationXref
id: 5650102
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650102

UnificationXref18132
type: UnificationXref
id: 5650103
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650103

UnificationXref18130
type: UnificationXref
id: 5650101
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650101

http://identifiers.org/pubmed/15585754
type: PublicationXref
id: 15585754
author: Hicklin, DJ
author: Ellis, LM
db: Pubmed
title: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
source: J Clin Oncol 23:1011-27
year: 2005

UniProt:P49029
type: ProteinReference
name: mag-1
xref: UnificationXref19257
organism: http://identifiers.org/taxonomy/6239

RelationshipXref2541
type: RelationshipXref
id: 5633946
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633946

RelationshipXref2540
type: RelationshipXref
id: 5633297
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633297

http://identifiers.org/pubmed/11208594
type: PublicationXref
id: 11208594
author: Rabelink, TJ
author: Govers, R
db: Pubmed
title: Cellular regulation of endothelial nitric oxide synthase
source: Am J Physiol Renal Physiol 280:F193-206
year: 2001

RelationshipXref2543
type: RelationshipXref
id: 5635244
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635244

RelationshipXref2542
type: RelationshipXref
id: 5634526
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5634526

RelationshipXref2545
type: RelationshipXref
id: 5624291
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624291

RelationshipXref2544
type: RelationshipXref
id: 5635258
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635258

RelationshipXref2547
type: RelationshipXref
id: GO:0004676
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2546
type: RelationshipXref
id: 5635195
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635195

RelationshipXref2548
type: RelationshipXref
id: 5635203
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635203

RelationshipXref2549
type: RelationshipXref
id: GO:0004698
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/12123608
type: PublicationXref
id: 12123608
author: Swiercz, JM
author: Offermanns, S
author: Behrens, J
author: Kuner, R
db: Pubmed
title: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology
source: Neuron 35:51-63
year: 2002

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

UnificationXref18199
type: UnificationXref
id: REACT_241336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241336.1

UnificationXref18196
type: UnificationXref
id: 5639491
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639491

UnificationXref18195
type: UnificationXref
id: REACT_263217
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263217.1

UnificationXref18198
type: UnificationXref
id: 5639526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639526

UnificationXref18197
type: UnificationXref
id: 5639504
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639504

UnificationXref18192
type: UnificationXref
id: 5639490
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639490

UnificationXref18191
type: UnificationXref
id: REACT_248660
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248660.1

UnificationXref11209
type: UnificationXref
id: 164121
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=164121

UnificationXref18194
type: UnificationXref
id: 5639568
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639568

UnificationXref11208
type: UnificationXref
id: 5624845
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624845

UnificationXref18193
type: UnificationXref
id: 5639536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639536

RelationshipXref2532
type: RelationshipXref
id: 5629897
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5629897

RelationshipXref2531
type: RelationshipXref
id: GO:0006309
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2530
type: RelationshipXref
id: GO:0097193
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref18190
type: UnificationXref
id: 5639528
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639528

RelationshipXref2536
type: RelationshipXref
id: GO:0042981
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2535
type: RelationshipXref
id: GO:0043066
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2534
type: RelationshipXref
id: GO:0006921
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2533
type: RelationshipXref
id: 5629892
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5629892

http://identifiers.org/pubmed/9914469
type: PublicationXref
id: 9914469
author: Lang, J
db: Pubmed
title: Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
source: Eur J Biochem 259:3-17
year: 1999

RelationshipXref2539
type: RelationshipXref
id: GO:0047555
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2537
type: RelationshipXref
id: GO:0006915
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2538
type: RelationshipXref
id: 5632855
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632855

UnificationXref11206
type: UnificationXref
id: 5624844
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624844

UnificationXref11207
type: UnificationXref
id: REACT_210369
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210369.2

UnificationXref11204
type: UnificationXref
id: 5652878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652878

UnificationXref11205
type: UnificationXref
id: REACT_229695
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229695.1

http://identifiers.org/pubmed/12123613
type: PublicationXref
id: 12123613
author: Janus, Christopher
author: Meng, Yanghong
author: Falls, Douglas L
author: Cruz, Luis
author: Wang, Jay Y
author: Tregoubov, Vitali
author: Jia, Zhengping
author: Jackson, Mike
author: MacDonald, John F
author: Lu, Wei Yang
author: Zhang, Yu
db: Pubmed
title: Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice
source: Neuron 35:121-33
year: 2002

UnificationXref11202
type: UnificationXref
id: 5652876
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652876

UnificationXref18188
type: UnificationXref
id: 5639523
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639523

UnificationXref11203
type: UnificationXref
id: REACT_249042
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249042.1

UnificationXref18189
type: UnificationXref
id: 5639524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639524

UnificationXref11200
type: UnificationXref
id: 5624771
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624771

UnificationXref11201
type: UnificationXref
id: REACT_245681
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245681.1

UnificationXref18183
type: UnificationXref
id: 5639518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639518

UnificationXref18182
type: UnificationXref
id: 5639517
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639517

UnificationXref18181
type: UnificationXref
id: 5639516
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639516

UnificationXref18180
type: UnificationXref
id: 5639514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639514

UnificationXref18187
type: UnificationXref
id: 5639522
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639522

UnificationXref18186
type: UnificationXref
id: 5639521
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639521

UnificationXref18185
type: UnificationXref
id: 5639520
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639520

UnificationXref18184
type: UnificationXref
id: 5639519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639519

RelationshipXref2523
type: RelationshipXref
id: 5648701
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648701

RelationshipXref2522
type: RelationshipXref
id: GO:0030574
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2525
type: RelationshipXref
id: GO:0022617
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2524
type: RelationshipXref
id: 5650845
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650845

RelationshipXref2521
type: RelationshipXref
id: 5647493
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5647493

RelationshipXref2520
type: RelationshipXref
id: 5647366
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5647366

RelationshipXref2526
type: RelationshipXref
id: GO:0030198
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2527
type: RelationshipXref
id: GO:0035036
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2528
type: RelationshipXref
id: GO:0007338
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2529
type: RelationshipXref
id: GO:0032504
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref18179
type: UnificationXref
id: 5639512
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639512

UnificationXref18177
type: UnificationXref
id: 5639508
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639508

rps-5
type: ProteinReference
name: UniProt:P49041
xref: UnificationXref20331
organism: http://identifiers.org/taxonomy/6239

UnificationXref18178
type: UnificationXref
id: 5639510
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639510

UnificationXref18170
type: UnificationXref
id: REACT_246293
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246293.1

UnificationXref18172
type: UnificationXref
id: 5639480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639480

http://identifiers.org/pubmed/16761954
type: PublicationXref
id: 16761954
author: De Vuyst, E
author: Leybaert, L
author: Evans, WH
db: Pubmed
title: The gap junction cellular internet: connexin hemichannels enter the signalling limelight
source: Biochem J 397:1-14
year: 2006

UnificationXref18171
type: UnificationXref
id: 5639487
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639487

UnificationXref18174
type: UnificationXref
id: REACT_233301
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233301.1

UnificationXref18173
type: UnificationXref
id: 5639564
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639564

UnificationXref18176
type: UnificationXref
id: 5639527
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639527

UnificationXref18175
type: UnificationXref
id: 5639489
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639489

RelationshipXref2514
type: RelationshipXref
id: 5645259
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645259

RelationshipXref2513
type: RelationshipXref
id: GO:0003755
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2512
type: RelationshipXref
id: 5643699
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643699

RelationshipXref2511
type: RelationshipXref
id: GO:0033823
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2510
type: RelationshipXref
id: 5643668
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643668

RelationshipXref2519
type: RelationshipXref
id: 5648490
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648490

RelationshipXref2517
type: RelationshipXref
id: 5641904
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5641904

RelationshipXref2518
type: RelationshipXref
id: 5646927
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5646927

RelationshipXref2515
type: RelationshipXref
id: 5645154
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645154

RelationshipXref2516
type: RelationshipXref
id: 5645161
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645161

UnificationXref18166
type: UnificationXref
id: REACT_234718
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234718.1

UnificationXref18167
type: UnificationXref
id: 5639486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639486

UnificationXref18168
type: UnificationXref
id: 5639478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639478

UnificationXref18169
type: UnificationXref
id: 5639566
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639566

SequenceSite19019
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19017
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19018
type: SequenceSite
position status: EQUAL
sequence position: 892

G-protein activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction2176
evidence: Evidence3143
xref: UnificationXref24530
xref: UnificationXref24531
pathway order: PathwayStep3115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11238
type: UnificationXref
id: 5652874
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652874

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1472
evidence: Evidence2049
xref: UnificationXref15587
xref: UnificationXref15586
pathway order: PathwayStep2035
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11237
type: UnificationXref
id: 5624826
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624826

UnificationXref11239
type: UnificationXref
id: REACT_202173
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_202173.2

UnificationXref11234
type: UnificationXref
id: 5624827
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624827

UnificationXref11233
type: UnificationXref
id: REACT_247310
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247310.1

UnificationXref11236
type: UnificationXref
id: REACT_3744
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3744.1

UnificationXref11235
type: UnificationXref
id: 163730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=163730

SequenceSite19012
type: SequenceSite
position status: EQUAL
sequence position: 926

UnificationXref11230
type: UnificationXref
id: REACT_211775
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211775.2

SequenceSite19011
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19010
type: SequenceSite
position status: EQUAL
sequence position: 855

UnificationXref11232
type: UnificationXref
id: 5624825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624825

UnificationXref11231
type: UnificationXref
id: 5624817
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624817

SequenceSite19016
type: SequenceSite
position status: EQUAL
sequence position: 892

SequenceSite19015
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19014
type: SequenceSite
position status: EQUAL
sequence position: 219

SequenceSite19013
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19028
type: SequenceSite
position status: EQUAL
sequence position: 488

SequenceSite19029
type: SequenceSite
position status: EQUAL
sequence position: 98

http://identifiers.org/pubmed/16868246
type: PublicationXref
id: 16868246
author: Berggren, PO
author: Yang, SN
db: Pubmed
title: The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
source: Endocr Rev 27:621-76
year: 2006

UnificationXref11249
type: UnificationXref
id: REACT_256160
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256160.1

UnificationXref11248
type: UnificationXref
id: 5624848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624848

UnificationXref11247
type: UnificationXref
id: 5624800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624800

UnificationXref11246
type: UnificationXref
id: 5624799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624799

UnificationXref11245
type: UnificationXref
id: 5624798
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624798

UnificationXref11244
type: UnificationXref
id: 5624796
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624796

SequenceSite19021
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11243
type: UnificationXref
id: 5624794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624794

SequenceSite19020
type: SequenceSite
position status: EQUAL
sequence position: 892

UnificationXref11242
type: UnificationXref
id: 5624792
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624792

SequenceSite19023
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref11241
type: UnificationXref
id: REACT_231679
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231679.1

SequenceSite19022
type: SequenceSite
position status: EQUAL
sequence position: 892

UnificationXref11240
type: UnificationXref
id: 5624815
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624815

SequenceSite19025
type: SequenceSite
position status: EQUAL
sequence position: 18

SequenceSite19024
type: SequenceSite
position status: EQUAL
sequence position: 1948

SequenceSite19027
type: SequenceSite
position status: EQUAL
sequence position: 32

SequenceSite19026
type: SequenceSite
position status: EQUAL
sequence position: 303

RelationshipXref2566
type: RelationshipXref
id: GO:0045216
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2567
type: RelationshipXref
id: GO:0034329
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2568
type: RelationshipXref
id: GO:0016071
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2569
type: RelationshipXref
id: GO:0016070
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2562
type: RelationshipXref
id: GO:0046899
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2563
type: RelationshipXref
id: 5639072
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639072

RelationshipXref2564
type: RelationshipXref
id: GO:0007623
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2565
type: RelationshipXref
id: GO:0034332
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref11219
type: UnificationXref
id: 5624760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624760

RelationshipXref2560
type: RelationshipXref
id: 5629625
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5629625

RelationshipXref2561
type: RelationshipXref
id: GO:0050900
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref11212
type: UnificationXref
id: 5624753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624753

UnificationXref11211
type: UnificationXref
id: 5624749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624749

UnificationXref11214
type: UnificationXref
id: 5624740
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624740

UnificationXref11213
type: UnificationXref
id: 5624754
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624754

UnificationXref11216
type: UnificationXref
id: 5624745
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624745

UnificationXref11215
type: UnificationXref
id: 5624744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624744

UnificationXref11218
type: UnificationXref
id: 5624759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624759

UnificationXref11217
type: UnificationXref
id: 5624758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624758

UnificationXref11210
type: UnificationXref
id: REACT_2883
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2883.1

RelationshipXref2557
type: RelationshipXref
id: GO:0004867
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2558
type: RelationshipXref
id: 5624609
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624609

RelationshipXref2555
type: RelationshipXref
id: GO:0007597
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2556
type: RelationshipXref
id: GO:0007596
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2553
type: RelationshipXref
id: GO:0002576
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite19006
type: SequenceSite
position status: EQUAL
sequence position: 913

RelationshipXref2554
type: RelationshipXref
id: GO:0030168
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite19007
type: SequenceSite
position status: EQUAL
sequence position: 22

RelationshipXref2551
type: RelationshipXref
id: GO:0015662
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite19008
type: SequenceSite
position status: EQUAL
sequence position: 855

RelationshipXref2552
type: RelationshipXref
id: 5634552
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5634552

SequenceSite19009
type: SequenceSite
position status: EQUAL
sequence position: 22

RelationshipXref2550
type: RelationshipXref
id: 5624250
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624250

UnificationXref11225
type: UnificationXref
id: 5624822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624822

UnificationXref11224
type: UnificationXref
id: 5624821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624821

UnificationXref11223
type: UnificationXref
id: 5624819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624819

UnificationXref11222
type: UnificationXref
id: REACT_222175
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_222175.2

UnificationXref11229
type: UnificationXref
id: 5624854
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624854

UnificationXref11228
type: UnificationXref
id: 5624852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624852

UnificationXref11227
type: UnificationXref
id: Q9GN62
db: UniProt

UnificationXref11226
type: UnificationXref
id: 5624823
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624823

SequenceSite19003
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite19002
type: SequenceSite
position status: EQUAL
sequence position: 1375

SequenceSite19005
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite19004
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref11221
type: UnificationXref
id: 5624762
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624762

UnificationXref11220
type: UnificationXref
id: 5624761
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624761

SequenceSite19001
type: SequenceSite
position status: EQUAL
sequence position: 31

RelationshipXref2559
type: RelationshipXref
id: GO:0042730
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite19000
type: SequenceSite
position status: EQUAL
sequence position: 1375

UnificationXref11160
type: UnificationXref
id: Q86G45
db: UniProt

UnificationXref11161
type: UnificationXref
id: 5630151
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630151

UnificationXref11162
type: UnificationXref
id: G4SFC3
db: UniProt

UnificationXref11163
type: UnificationXref
id: 5630153
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630153

UnificationXref11164
type: UnificationXref
id: Q7YZH2
db: UniProt

UnificationXref11165
type: UnificationXref
id: 5630155
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630155

UnificationXref11166
type: UnificationXref
id: 5630156
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630156

UnificationXref11167
type: UnificationXref
id: 5630157
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630157

UnificationXref11168
type: UnificationXref
id: 5630158
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630158

UnificationXref11169
type: UnificationXref
id: 5630159
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630159

Y32G9A.6
type: ProteinReference
name: UniProt:Q9BPN3
xref: UnificationXref7276
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

UnificationXref11150
type: UnificationXref
id: 5630125
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630125

UnificationXref11151
type: UnificationXref
id: 5630139
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630139

UnificationXref11154
type: UnificationXref
id: 5630142
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630142

UnificationXref11155
type: UnificationXref
id: 5630143
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630143

UnificationXref11152
type: UnificationXref
id: 5630140
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630140

UnificationXref11153
type: UnificationXref
id: 5630141
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630141

UnificationXref11158
type: UnificationXref
id: G5EFB0
db: UniProt

UnificationXref11159
type: UnificationXref
id: 5630149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630149

UnificationXref11156
type: UnificationXref
id: Q8MPY5
db: UniProt

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

UnificationXref11157
type: UnificationXref
id: 5630147
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630147

UniProt:Q9BPM4
type: ProteinReference
name: gst-37
xref: UnificationXref13968
organism: http://identifiers.org/taxonomy/6239

UnificationXref11141
type: UnificationXref
id: 5630132
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630132

UnificationXref11142
type: UnificationXref
id: O01661
db: UniProt

UnificationXref11143
type: UnificationXref
id: 5630136
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630136

UnificationXref11144
type: UnificationXref
id: 5630137
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630137

UnificationXref11140
type: UnificationXref
id: 5630131
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630131

UnificationXref11149
type: UnificationXref
id: 5630124
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630124

UnificationXref11145
type: UnificationXref
id: 5630138
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630138

UnificationXref11146
type: UnificationXref
id: Q8MQA1
db: UniProt

UnificationXref11147
type: UnificationXref
id: 5630122
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630122

UnificationXref11148
type: UnificationXref
id: G5EG02
db: UniProt

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

UnificationXref11132
type: UnificationXref
id: 5624701
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624701

UnificationXref11133
type: UnificationXref
id: 5624702
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624702

UnificationXref11130
type: UnificationXref
id: 5624697
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624697

UnificationXref11131
type: UnificationXref
id: P91270
db: UniProt

UnificationXref11138
type: UnificationXref
id: 5630129
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630129

UnificationXref11139
type: UnificationXref
id: G5EG74
db: UniProt

UnificationXref11136
type: UnificationXref
id: REACT_233856
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233856.1

UnificationXref11137
type: UnificationXref
id: G5EGL3
db: UniProt

UnificationXref11134
type: UnificationXref
id: 5624703
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624703

UnificationXref11135
type: UnificationXref
id: 5624705
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624705

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1480
evidence: Evidence2071
xref: UnificationXref15708
xref: UnificationXref15709
pathway order: PathwayStep2057
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

Fructose catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction505
evidence: Evidence719
xref: UnificationXref5718
xref: UnificationXref5717
xref: RelationshipXref442
pathway order: PathwayStep715
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11195
type: UnificationXref
id: 5624860
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624860

UnificationXref11194
type: UnificationXref
id: 5624769
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624769

UnificationXref11193
type: UnificationXref
id: REACT_247936
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247936.1

UnificationXref11192
type: UnificationXref
id: 5624773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624773

UnificationXref11199
type: UnificationXref
id: REACT_243712
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243712.1

UnificationXref11198
type: UnificationXref
id: 5624777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624777

UnificationXref11197
type: UnificationXref
id: 5624775
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624775

UnificationXref11196
type: UnificationXref
id: REACT_238729
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238729.1

UnificationXref11189
type: UnificationXref
id: P41846
db: UniProt

UnificationXref11186
type: UnificationXref
id: REACT_244831
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244831.1

UnificationXref11185
type: UnificationXref
id: 5652802
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652802

UnificationXref11188
type: UnificationXref
id: REACT_257245
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_257245.1

UnificationXref11187
type: UnificationXref
id: 5652803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652803

UnificationXref11182
type: UnificationXref
id: REACT_251806
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251806.1

UnificationXref11181
type: UnificationXref
id: 5624736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624736

UnificationXref11184
type: UnificationXref
id: REACT_256162
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256162.1

UnificationXref11183
type: UnificationXref
id: 5624856
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624856

UnificationXref11190
type: UnificationXref
id: 5624766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624766

UnificationXref11191
type: UnificationXref
id: 5624770
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624770

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

UnificationXref11179
type: UnificationXref
id: REACT_248744
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248744.1

UnificationXref11178
type: UnificationXref
id: 5652870
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652870

UnificationXref11177
type: UnificationXref
id: REACT_253739
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253739.1

UnificationXref11176
type: UnificationXref
id: 5630167
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630167

UnificationXref11175
type: UnificationXref
id: 5630165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630165

UnificationXref11174
type: UnificationXref
id: 5630164
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630164

http://identifiers.org/pubmed/10487978
type: PublicationXref
id: 10487978
author: Walsh, DA
author: Brushia, RJ
db: Pubmed
title: Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure
source: Front Biosci 4:D618-41
year: 1999

UnificationXref11173
type: UnificationXref
id: 5630163
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630163

UnificationXref11172
type: UnificationXref
id: 5630162
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630162

UnificationXref11171
type: UnificationXref
id: 5630161
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630161

UnificationXref11170
type: UnificationXref
id: 5630160
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630160

UnificationXref11180
type: UnificationXref
id: 5624735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624735

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

http://identifiers.org/pubmed/9593664
type: PublicationXref
id: 9593664
author: Maehama, T
author: Dixon, JE
db: Pubmed
title: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
source: J Biol Chem 273:13375-8
year: 1998

UniProt:P24612
type: ProteinReference
name: mec-4
xref: UnificationXref17648
organism: http://identifiers.org/taxonomy/6239

DNA Damage Recognition in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1989
pathway component: BiochemicalReaction1990
evidence: Evidence2851
xref: UnificationXref22537
xref: UnificationXref22536
xref: RelationshipXref2228
pathway order: PathwayStep2828
pathway order: PathwayStep2827
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12515866
type: PublicationXref
id: 12515866
author: Nakamura, S
author: Suzuki, N
author: Kozasa, T
author: Mano, H
db: Pubmed
title: Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
source: Proc Natl Acad Sci U S A 100:733-8
year: 2003

http://identifiers.org/pubmed/11023514
type: PublicationXref
id: 11023514
author: Zhang, J
author: Roifman, CM
author: Chitayat, D
author: Sharfe, N
db: Pubmed
title: A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
source: Blood 96:2803-7
year: 2000

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

http://identifiers.org/pubmed/11278508
type: PublicationXref
id: 11278508
author: Chairoungdua, A
author: Kanai, Y
author: Kim, DK
author: Matsuo, H
author: Cha, SH
author: Endou, H
db: Pubmed
title: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
source: J Biol Chem 276:17221-8
year: 2001

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

UnificationXref18210
type: UnificationXref
id: 5639462
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639462

UnificationXref18211
type: UnificationXref
id: 5639464
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639464

UnificationXref18212
type: UnificationXref
id: 5639469
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639469

UnificationXref18213
type: UnificationXref
id: 5639481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639481

UnificationXref18214
type: UnificationXref
id: 5639494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639494

UnificationXref18215
type: UnificationXref
id: 5639569
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639569

UnificationXref18216
type: UnificationXref
id: REACT_240824
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240824.1

UnificationXref18217
type: UnificationXref
id: 5639540
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639540

UnificationXref18218
type: UnificationXref
id: 5624057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624057

UnificationXref18219
type: UnificationXref
id: 5624061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624061

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

http://identifiers.org/pubmed/13115432
type: PublicationXref
id: 13115432
author: Cori, GT
author: Keller, PJ
db: Pubmed
title: Enzymic conversion of phosphorylase a to phosphorylase b
source: Biochim Biophys Acta 12:235-8
year: 1953

http://identifiers.org/pubmed/9809982
type: PublicationXref
id: 9809982
author: Reiss, M
author: Garrigue-Antar, L
author: Chen, Taiping
author: Carter, Darryl
db: Pubmed
title: Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer
source: Cancer Res. 58:4805-10
year: 1998

http://identifiers.org/pubmed/13295248
type: PublicationXref
id: 13295248
author: Stern, JR
author: Del Campillo, A
db: Pubmed
title: Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
source: J Biol Chem 218:985-1002
year: 1956

UnificationXref18220
type: UnificationXref
id: 5624065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624065

UnificationXref18201
type: UnificationXref
id: 5639468
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639468

UnificationXref18202
type: UnificationXref
id: G5ECR7
db: UniProt

http://identifiers.org/pubmed/20357282
type: PublicationXref
id: 20357282
author: Moslemi, Ali-Reza
author: Nilsson, Johanna
author: Andersson, Bert
author: Lindberg, Christopher
author: Tajsharghi, Homa
author: Oldfors, A
db: Pubmed
title: Glycogenin-1 deficiency and inactivated priming of glycogen synthesis
source: N. Engl. J. Med. 362:1203-10
year: 2010

UnificationXref18200
type: UnificationXref
id: Q17390
db: UniProt

UnificationXref18205
type: UnificationXref
id: 5639459
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639459

UnificationXref18206
type: UnificationXref
id: Q9BKS1
db: UniProt

UnificationXref18203
type: UnificationXref
id: 5639463
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639463

UnificationXref18204
type: UnificationXref
id: B1Q256
db: UniProt

UnificationXref18209
type: UnificationXref
id: 5639461
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639461

UnificationXref18207
type: UnificationXref
id: 5639460
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639460

UnificationXref18208
type: UnificationXref
id: Q23153
db: UniProt

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

http://identifiers.org/pubmed/9634703
type: PublicationXref
id: 9634703
author: Párraga, A
author: Bellsolell, L
author: Burley, SK
author: Ferré-D'Amaré, AR
db: Pubmed
title: Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
source: Structure 6:661-72
year: 1998

UnificationXref18236
type: UnificationXref
id: 5639545
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639545

UnificationXref18237
type: UnificationXref
id: 5639546
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639546

UnificationXref18238
type: UnificationXref
id: 5639547
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639547

UnificationXref18239
type: UnificationXref
id: 5639549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639549

UnificationXref18232
type: UnificationXref
id: 5639482
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639482

UnificationXref18233
type: UnificationXref
id: 5639483
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639483

UnificationXref18234
type: UnificationXref
id: 5639497
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639497

UnificationXref18235
type: UnificationXref
id: REACT_248712
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248712.1

UnificationXref18240
type: UnificationXref
id: REACT_230839
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230839.1

UnificationXref18242
type: UnificationXref
id: REACT_243369
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243369.1

UnificationXref18241
type: UnificationXref
id: 5639565
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639565

UnificationXref18227
type: UnificationXref
id: 5639542
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639542

UnificationXref18228
type: UnificationXref
id: 5639543
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639543

UnificationXref18225
type: UnificationXref
id: 5639541
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639541

UnificationXref18226
type: UnificationXref
id: 5639537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639537

UnificationXref18223
type: UnificationXref
id: 5639538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639538

UnificationXref18224
type: UnificationXref
id: 5639539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639539

UnificationXref18221
type: UnificationXref
id: 5624066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624066

UnificationXref18222
type: UnificationXref
id: 5624070
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624070

UnificationXref18229
type: UnificationXref
id: REACT_243547
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243547.1

UnificationXref18231
type: UnificationXref
id: 5639495
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639495

UnificationXref18230
type: UnificationXref
id: 5638081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638081

UnificationXref18255
type: UnificationXref
id: REACT_238548
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238548.1

UnificationXref18254
type: UnificationXref
id: 5639544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639544

UnificationXref18257
type: UnificationXref
id: 5639535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639535

UnificationXref18256
type: UnificationXref
id: 5639534
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639534

UnificationXref18259
type: UnificationXref
id: 5639577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639577

UnificationXref18258
type: UnificationXref
id: REACT_233748
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233748.1

UnificationXref18260
type: UnificationXref
id: REACT_230702
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230702.1

UnificationXref18261
type: UnificationXref
id: 5639578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639578

UnificationXref18262
type: UnificationXref
id: 5653359
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653359

UnificationXref18263
type: UnificationXref
id: REACT_238138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238138.1

UnificationXref18264
type: UnificationXref
id: 5653357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653357

UnificationXref18246
type: UnificationXref
id: REACT_256147
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256147.1

UnificationXref18245
type: UnificationXref
id: 5653356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653356

UnificationXref18244
type: UnificationXref
id: REACT_232799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232799.1

UnificationXref18243
type: UnificationXref
id: 5639484
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639484

UniProt:A9CZN9
type: ProteinReference
xref: UnificationXref13412
organism: http://identifiers.org/taxonomy/6239

UnificationXref18249
type: UnificationXref
id: 5639493
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639493

UnificationXref18248
type: UnificationXref
id: 5639492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639492

UnificationXref18247
type: UnificationXref
id: 5639488
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639488

UnificationXref18252
type: UnificationXref
id: 5639532
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639532

UnificationXref18253
type: UnificationXref
id: 5639533
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639533

UnificationXref18250
type: UnificationXref
id: REACT_252415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252415.1

UnificationXref18251
type: UnificationXref
id: O02219
db: UniProt

http://identifiers.org/pubmed/10652257
type: PublicationXref
id: 10652257
author: Wakelam, MJ
author: Cross, MJ
author: Roberts, S
author: Claesson-Welsh, L
author: Landgren, E
author: Hodgkin, MN
db: Pubmed
title: Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
source: J Cell Sci 113:643-51
year: 2000

http://identifiers.org/pubmed/10496324
type: PublicationXref
id: 10496324
author: Dharmawardhane, S
author: Lennartz, M
author: Bokoch, GM
author: Brownson, D
db: Pubmed
title: Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
source: J Leukoc Biol 66:521-7
year: 1999

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

UnificationXref18277
type: UnificationXref
id: 5650160
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650160

UnificationXref18276
type: UnificationXref
id: 5650694
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650694

UnificationXref18279
type: UnificationXref
id: 5650695
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650695

UnificationXref18278
type: UnificationXref
id: 5650161
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650161

UnificationXref18283
type: UnificationXref
id: 5650149
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650149

UnificationXref18284
type: UnificationXref
id: 5650150
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650150

UnificationXref18285
type: UnificationXref
id: 5650151
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650151

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

UnificationXref18286
type: UnificationXref
id: 5650165
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650165

UnificationXref18280
type: UnificationXref
id: REACT_262457
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_262457.1

UnificationXref18281
type: UnificationXref
id: 5650162
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650162

UnificationXref18282
type: UnificationXref
id: 5650163
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650163

http://identifiers.org/pubmed/14602708
type: PublicationXref
id: 14602708
author: Pietka, T
author: Eyre, DR
author: Wu, JJ
author: Weis, MA
db: Pubmed
title: Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage
source: J Biol Chem 279:2568-74
year: 2004

http://identifiers.org/pubmed/17371249
type: PublicationXref
id: 17371249
author: Wu, H
author: Backer, JM
author: Yan, Y
db: Pubmed
title: Regulation of class IA PI3Ks
source: Biochem Soc Trans 35:242-4
year: 2007

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

UnificationXref18269
type: UnificationXref
id: 5636593
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636593

UnificationXref18268
type: UnificationXref
id: Q27538
db: UniProt

UnificationXref18267
type: UnificationXref
id: REACT_256909
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256909.1

UnificationXref18266
type: UnificationXref
id: 5653358
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653358

UnificationXref18265
type: UnificationXref
id: REACT_242277
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242277.1

UnificationXref18274
type: UnificationXref
id: REACT_173485
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173485.1

UnificationXref18275
type: UnificationXref
id: 5650159
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650159

UnificationXref18272
type: UnificationXref
id: CHEBI:49552
db: ChEBI

UnificationXref18273
type: UnificationXref
id: 3299744
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3299744

UnificationXref18270
type: UnificationXref
id: P34697
db: UniProt

UnificationXref18271
type: UnificationXref
id: 5650158
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650158

UnificationXref18298
type: UnificationXref
id: 5650777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650777

UnificationXref18299
type: UnificationXref
id: REACT_254590
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254590.1

http://identifiers.org/pubmed/10615129
type: PublicationXref
id: 10615129
author: Mauro, T
author: Ikeda, S
author: Bonifas, JM
author: Beech, J
author: Bench, G
author: Ogawa, H
author: Hu, Z
author: Shigihara, T
author: Epstein EH, Jr
db: Pubmed
title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
source: Nat Genet 24:61-5
year: 2000

UnificationXref18291
type: UnificationXref
id: 3777117
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3777117

UnificationXref18290
type: UnificationXref
id: 5650771
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650771

UnificationXref18293
type: UnificationXref
id: 5650772
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650772

UnificationXref18292
type: UnificationXref
id: REACT_173282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173282.1

UnificationXref18295
type: UnificationXref
id: 5650774
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650774

UnificationXref18294
type: UnificationXref
id: 5650773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650773

UnificationXref18297
type: UnificationXref
id: 5650776
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650776

UnificationXref18296
type: UnificationXref
id: 5650775
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650775

UnificationXref18287
type: UnificationXref
id: REACT_263628
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_263628.1

UnificationXref18288
type: UnificationXref
id: 3780989
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3780989

UnificationXref18289
type: UnificationXref
id: REACT_173520
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_173520.1

UnificationXref11109
type: UnificationXref
id: 5632024
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632024

UnificationXref11100
type: UnificationXref
id: 5632019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632019

UnificationXref11104
type: UnificationXref
id: P34578
db: UniProt

UnificationXref11103
type: UnificationXref
id: 5632021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632021

UnificationXref11102
type: UnificationXref
id: REACT_232582
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232582.1

UnificationXref11101
type: UnificationXref
id: 5632020
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632020

UnificationXref11108
type: UnificationXref
id: 5632023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632023

UnificationXref11107
type: UnificationXref
id: REACT_18677
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18677.2

UnificationXref11106
type: UnificationXref
id: 400570
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400570

UnificationXref11105
type: UnificationXref
id: 5632022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632022

http://identifiers.org/pubmed/13295225
type: PublicationXref
id: 13295225
author: Crane, FL
author: Beinert, H
db: Pubmed
title: On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein.
source: J Biol Chem 218:717-31
year: 1956

UnificationXref11111
type: UnificationXref
id: 5632009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632009

UnificationXref11110
type: UnificationXref
id: REACT_256192
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256192.1

UnificationXref11117
type: UnificationXref
id: 5630579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630579

UnificationXref11116
type: UnificationXref
id: 5630560
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630560

UnificationXref11119
type: UnificationXref
id: 5632060
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632060

UnificationXref11118
type: UnificationXref
id: 5630561
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630561

UnificationXref11113
type: UnificationXref
id: 5632011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632011

UnificationXref11112
type: UnificationXref
id: 5632010
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632010

UnificationXref11115
type: UnificationXref
id: Q18246
db: UniProt

UnificationXref11114
type: UnificationXref
id: REACT_238758
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238758.1

Platelet homeostasis
type: Pathway
data source: Provenance1
pathway component: REACT 250761.1
pathway component: REACT 244242.1
evidence: Evidence3718
xref: UnificationXref30686
xref: UnificationXref30685
pathway order: PathwayStep3672
pathway order: PathwayStep3676
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11122
type: UnificationXref
id: 5632062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632062

UnificationXref11121
type: UnificationXref
id: 5632061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632061

UnificationXref11120
type: UnificationXref
id: REACT_242798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242798.1

UnificationXref11129
type: UnificationXref
id: 5624696
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624696

UnificationXref11128
type: UnificationXref
id: Q21809
db: UniProt

UnificationXref11127
type: UnificationXref
id: REACT_218145
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_218145.2

UnificationXref11126
type: UnificationXref
id: 5636672
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636672

UnificationXref11125
type: UnificationXref
id: 5636670
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636670

UnificationXref11124
type: UnificationXref
id: REACT_249220
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249220.1

UnificationXref11123
type: UnificationXref
id: 5653153
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653153

UnificationXref11028
type: UnificationXref
id: 5624275
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624275

UnificationXref11029
type: UnificationXref
id: Q20701
db: UniProt

UnificationXref11024
type: UnificationXref
id: 5624267
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624267

UnificationXref11025
type: UnificationXref
id: O76584
db: UniProt

UnificationXref11026
type: UnificationXref
id: 5624271
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624271

UnificationXref11027
type: UnificationXref
id: Q9BIG2
db: UniProt

UnificationXref11020
type: UnificationXref
id: Q8T3G5
db: UniProt

UnificationXref11021
type: UnificationXref
id: 5624262
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624262

UnificationXref11022
type: UnificationXref
id: 5624263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624263

UnificationXref11023
type: UnificationXref
id: Q9XTB2
db: UniProt

http://identifiers.org/pubmed/9844003
type: PublicationXref
id: 9844003
author: Leonhard, S
author: Bittiger, H
author: Pfaff, T
author: Kaupmann, K
author: Bettler, B
author: Karschin, A
author: Froestl, W
author: Schuler, V
author: Bischoff, S
author: Heid, J
author: Mosbacher, J
db: Pubmed
title: Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels
source: Proc Natl Acad Sci U S A 95:14991-6
year: 1998

kin-3
type: ProteinReference
name: UniProt:P18334
xref: UnificationXref7055
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/10397761
type: PublicationXref
id: 10397761
author: Sato, R
author: Nagoshi, E
author: Yoneda, Y
author: Imamoto, N
db: Pubmed
title: Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
source: Mol Biol Cell 10:2221-33
year: 1999

UnificationXref11019
type: UnificationXref
id: 5624260
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624260

UnificationXref11017
type: UnificationXref
id: REACT_4514
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4514.1

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

UnificationXref11018
type: UnificationXref
id: G5EGU1
db: UniProt

UnificationXref11015
type: UnificationXref
id: REACT_102419
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102419.4

UnificationXref11016
type: UnificationXref
id: 114549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114549

UnificationXref11013
type: UnificationXref
id: 5633041
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633041

UnificationXref11014
type: UnificationXref
id: 5633048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633048

UnificationXref11011
type: UnificationXref
id: 399976
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=399976

UnificationXref11012
type: UnificationXref
id: REACT_18971
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18971.2

UnificationXref11010
type: UnificationXref
id: 5632679
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632679

http://identifiers.org/pubmed/9856482
type: PublicationXref
id: 9856482
author: Schnetkamp, PP
author: Tucker, JE
author: Walter, MA
author: Friedman, JS
author: Winkfein, RJ
author: Murthy, SK
author: Demetrick, DJ
db: Pubmed
title: Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger
source: Hum Genet 103:411-4
year: 1998

http://identifiers.org/pubmed/7506871
type: PublicationXref
id: 7506871
author: Hübner, S
author: Appelhans, H
author: Wagner, S
author: Drenckhahn, D
author: Kollert-Jöns, A
db: Pubmed
title: Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
source: Am J Physiol 265:F813-21
year: 1993

UnificationXref11046
type: UnificationXref
id: 114519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114519

UnificationXref11047
type: UnificationXref
id: REACT_3927
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3927.5

UnificationXref11048
type: UnificationXref
id: 5633047
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633047

UnificationXref11049
type: UnificationXref
id: REACT_259937
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259937.1

http://identifiers.org/pubmed/19373259
type: PublicationXref
id: 19373259
author: Pauli, Silke
author: Koch, HG
author: Linnebank, Michael
author: Häberle, Johannes
author: Berning, Christoph
db: Pubmed
title: TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations
source: J. Hum. Genet. 54:331-4
year: 2009

UnificationXref11040
type: UnificationXref
id: REACT_241295
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241295.1

UnificationXref11041
type: UnificationXref
id: 5633044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633044

UnificationXref11042
type: UnificationXref
id: 5633045
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633045

UnificationXref11043
type: UnificationXref
id: 5633051
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633051

UnificationXref11044
type: UnificationXref
id: REACT_229457
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229457.1

UnificationXref11045
type: UnificationXref
id: CHEBI:17815
db: ChEBI

http://identifiers.org/pubmed/20198122
type: PublicationXref
id: 20198122
author: La Cava, Antonio
author: Matarese, Giuseppe
author: Lam, Queenie Lai Kwan
author: Lu, Liwei
author: Iikuni, Noriko
db: Pubmed
title: Leptin and Inflammation
source: Curr Immunol Rev 4:70-79
year: 2008

UnificationXref11037
type: UnificationXref
id: 5633043
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633043

UnificationXref11038
type: UnificationXref
id: REACT_242654
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242654.1

UnificationXref11035
type: UnificationXref
id: 5633039
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633039

UnificationXref11036
type: UnificationXref
id: 5633040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633040

UnificationXref11039
type: UnificationXref
id: 5633052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633052

UnificationXref11030
type: UnificationXref
id: 5624279
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624279

UnificationXref11033
type: UnificationXref
id: 5633037
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633037

UnificationXref11034
type: UnificationXref
id: 5633038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633038

UnificationXref11031
type: UnificationXref
id: 5624280
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624280

UnificationXref11032
type: UnificationXref
id: 5633036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633036

UnificationXref11065
type: UnificationXref
id: 5632025
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632025

UnificationXref11064
type: UnificationXref
id: 5632003
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632003

UnificationXref11067
type: UnificationXref
id: 5632005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632005

UnificationXref11066
type: UnificationXref
id: REACT_259429
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259429.1

UnificationXref11061
type: UnificationXref
id: 5624733
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624733

UnificationXref11060
type: UnificationXref
id: G5EF72
db: UniProt

UnificationXref11063
type: UnificationXref
id: 5632002
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632002

UnificationXref11062
type: UnificationXref
id: 5624734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624734

UnificationXref11069
type: UnificationXref
id: G5EC00
db: UniProt

UnificationXref11068
type: UnificationXref
id: REACT_254671
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254671.1

UnificationXref11070
type: UnificationXref
id: 5632034
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632034

UnificationXref11056
type: UnificationXref
id: 5653190
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653190

UnificationXref11055
type: UnificationXref
id: REACT_231409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231409.1

UnificationXref11054
type: UnificationXref
id: 5653189
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653189

UnificationXref11053
type: UnificationXref
id: REACT_100621
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100621.4

UnificationXref11052
type: UnificationXref
id: 5633050
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633050

UnificationXref11051
type: UnificationXref
id: 5633049
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633049

UnificationXref11050
type: UnificationXref
id: 5624200
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624200

UnificationXref11059
type: UnificationXref
id: REACT_233808
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233808.1

UnificationXref11058
type: UnificationXref
id: 5653191
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653191

UnificationXref11057
type: UnificationXref
id: REACT_243018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243018.1

http://identifiers.org/pubmed/10648409
type: PublicationXref
id: 10648409
author: Hartwig, JH
author: Barkalow, K
author: Azim, AC
author: Chou, J
db: Pubmed
title: Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
source: Blood 95:959-64
year: 2000

UnificationXref11083
type: UnificationXref
id: Q8I4L2
db: UniProt

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

UnificationXref11082
type: UnificationXref
id: 5632050
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632050

UnificationXref11085
type: UnificationXref
id: G5EDK3
db: UniProt

UnificationXref11084
type: UnificationXref
id: 5632052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632052

UnificationXref11087
type: UnificationXref
id: G5ECD2
db: UniProt

UnificationXref11086
type: UnificationXref
id: 5632054
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632054

UnificationXref11089
type: UnificationXref
id: 5632057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632057

UnificationXref11088
type: UnificationXref
id: 5632056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632056

http://identifiers.org/pubmed/7138535
type: PublicationXref
id: 7138535
author: Ogawa, T
author: Tsuda, M
author: Ono, T
author: Kawanishi, Y
db: Pubmed
title: A novel fluor in insoluble collagen: a crosslinking moiety in collagen molecule
source: Biochem Biophys Res Commun 107:1252-7
year: 1982

http://identifiers.org/pubmed/4346946
type: PublicationXref
id: 4346946
author: Prockop, DJ
author: Berg, RA
db: Pubmed
title: Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme
source: J Biol Chem 248:1175-82
year: 1973

UnificationXref11090
type: UnificationXref
id: 5632058
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632058

UnificationXref11091
type: UnificationXref
id: REACT_229667
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229667.1

UnificationXref11092
type: UnificationXref
id: 5632059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632059

UnificationXref11074
type: UnificationXref
id: 5632040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632040

UnificationXref11073
type: UnificationXref
id: Q8I4L4
db: UniProt

UnificationXref11072
type: UnificationXref
id: 5632038
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632038

UnificationXref11071
type: UnificationXref
id: G5EFC3
db: UniProt

UnificationXref11078
type: UnificationXref
id: 5632044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632044

UnificationXref11077
type: UnificationXref
id: Q8I4L3
db: UniProt

UnificationXref11076
type: UnificationXref
id: 5632042
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632042

UnificationXref11075
type: UnificationXref
id: Q19464
db: UniProt

UnificationXref11079
type: UnificationXref
id: G5EEK7
db: UniProt

UnificationXref11080
type: UnificationXref
id: 5632048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632048

UnificationXref11081
type: UnificationXref
id: Q8I4L1
db: UniProt

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1695
pathway component: BiochemicalReaction1696
evidence: Evidence3293
xref: UnificationXref25532
xref: UnificationXref25531
xref: RelationshipXref2405
pathway order: PathwayStep2337
pathway order: PathwayStep2338
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11097
type: UnificationXref
id: 5632016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632016

UnificationXref11098
type: UnificationXref
id: 5632017
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632017

UnificationXref11099
type: UnificationXref
id: 5632018
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632018

UnificationXref11093
type: UnificationXref
id: 5632012
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632012

UnificationXref11094
type: UnificationXref
id: 5632013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632013

UnificationXref11095
type: UnificationXref
id: 5632014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632014

UnificationXref11096
type: UnificationXref
id: 5632015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632015

http://identifiers.org/pubmed/11389083
type: PublicationXref
id: 11389083
author: Fijan, A
author: Fehr, JL
author: Mihatsch, MJ
author: Anabitarte, M
author: Simon, R
author: Sauter, G
author: Bruderer, J
author: Gasser, T
author: Ackermann, D
author: Moch, H
author: Schmid, U
author: Maurer, R
author: Schraml, P
author: Flury, R
author: Richter, J
author: Wagner, U
author: Rist, M
author: Hardmeier, T
author: Knönagel, H
author: Wilber, K
author: Schönenberger, A
author: Hering, F
author: Jäger, P
author: Alund, G
db: Pubmed
title: High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer
source: Cancer Res 61:4514-9
year: 2001

http://identifiers.org/pubmed/16790503
type: PublicationXref
id: 16790503
author: Subramanian, VS
author: Marchant, JS
author: Said, HM
db: Pubmed
title: Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
source: Am J Physiol Cell Physiol 291:C851-9
year: 2006

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

F14B4.2
type: ProteinReference
name: UniProt:Q6BET1
xref: UnificationXref5094
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

F07B10.5
type: ProteinReference
name: UniProt:Q6BET0
xref: UnificationXref15456
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/10574708
type: PublicationXref
id: 10574708
author: Li, F
author: Zhang, Y
author: Wu, C
db: Pubmed
title: Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
source: J Cell Sci 112:4589-99
year: 1999

4-Aminobiphenyl
type: SmallMoleculeReference
name: 4-Aminobiphenyl [ChEBI:1784]
xref: UnificationXref13606

UniProt:Q6BEU0
type: ProteinReference
name: C06G8.3
xref: UnificationXref16626
organism: http://identifiers.org/taxonomy/6239

T26C5.3
type: ProteinReference
name: UniProt:Q6BEU8
xref: UnificationXref17039
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9124315
type: PublicationXref
id: 9124315
author: Huang, MY
author: Young, JD
author: Yao, SY
author: Ritzel, MW
author: Elliott, JF
author: Cass, CE
db: Pubmed
title: Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
source: Am J Physiol Cell Physiol 272:707-714
year: 1997

UniProt:Q6BEW1
type: ProteinReference
name: F27C1.2
xref: UnificationXref16684
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/18481987
type: PublicationXref
id: 18481987
author: Sandler, H
author: Stoecklin, G
db: Pubmed
title: Control of mRNA decay by phosphorylation of tristetraprolin
source: Biochem Soc Trans 36:491-6
year: 2008

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

SequenceSite19295
type: SequenceSite
position status: EQUAL
sequence position: 169

SequenceSite19296
type: SequenceSite
position status: EQUAL
sequence position: 412

SequenceSite19297
type: SequenceSite
position status: EQUAL
sequence position: 129

SequenceSite19298
type: SequenceSite
position status: EQUAL
sequence position: 333

SequenceSite19299
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19290
type: SequenceSite
position status: EQUAL
sequence position: 161

SequenceSite19291
type: SequenceSite
position status: EQUAL
sequence position: 65

SequenceSite19292
type: SequenceSite
position status: EQUAL
sequence position: 161

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

SequenceSite19293
type: SequenceSite
position status: EQUAL
sequence position: 169

SequenceSite19294
type: SequenceSite
position status: EQUAL
sequence position: 412

http://identifiers.org/pubmed/14993604
type: PublicationXref
id: 14993604
author: Goto, J
author: Eto, N
author: Mikkaichi, T
author: Okada, M
author: Tokui, T
author: Inui, K
author: Unno, M
author: Ito, S
author: Masuda, S
author: Hishinuma, T
author: Abe, T
author: Tanemoto, M
author: Onogawa, T
author: Mizutamari, H
author: Satoh, F
author: Suzuki, T
author: Chaki, T
author: Abe, M
db: Pubmed
title: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
source: Proc Natl Acad Sci U S A 101:3569-74
year: 2004

SequenceSite19277
type: SequenceSite
position status: EQUAL
sequence position: 114

SequenceSite19278
type: SequenceSite
position status: EQUAL
sequence position: 288

SequenceSite19279
type: SequenceSite
position status: EQUAL
sequence position: 292

SequenceSite19273
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19274
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19275
type: SequenceSite
position status: EQUAL
sequence position: 114

SequenceSite19276
type: SequenceSite
position status: EQUAL
sequence position: 288

SequenceSite19270
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19271
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19272
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19288
type: SequenceSite
position status: EQUAL
sequence position: 329

SequenceSite19289
type: SequenceSite
position status: EQUAL
sequence position: 65

SequenceSite19286
type: SequenceSite
position status: EQUAL
sequence position: 329

SequenceSite19287
type: SequenceSite
position status: EQUAL
sequence position: 115

SequenceSite19284
type: SequenceSite
position status: EQUAL
sequence position: 126

SequenceSite19285
type: SequenceSite
position status: EQUAL
sequence position: 115

SequenceSite19282
type: SequenceSite
position status: EQUAL
sequence position: 333

SequenceSite19283
type: SequenceSite
position status: EQUAL
sequence position: 80

SequenceSite19280
type: SequenceSite
position status: EQUAL
sequence position: 333

SequenceSite19281
type: SequenceSite
position status: EQUAL
sequence position: 292

SequenceSite19250
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19254
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19253
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19252
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19251
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

SequenceSite19258
type: SequenceSite
position status: EQUAL
sequence position: 1754

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

SequenceSite19257
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19256
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19255
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19259
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11009
type: UnificationXref
id: Q9U7D5
db: UniProt

UnificationXref11008
type: UnificationXref
id: REACT_224843
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224843.2

UnificationXref11007
type: UnificationXref
id: 5653193
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653193

UnificationXref11006
type: UnificationXref
id: REACT_219853
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_219853.2

UnificationXref11005
type: UnificationXref
id: 5632683
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632683

UnificationXref11004
type: UnificationXref
id: 5631738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631738

SequenceSite19261
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11003
type: UnificationXref
id: 5631737
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631737

SequenceSite19260
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref11002
type: UnificationXref
id: 5631736
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631736

SequenceSite19263
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11001
type: UnificationXref
id: 5631735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631735

SequenceSite19262
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref11000
type: UnificationXref
id: 5631734
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631734

SequenceSite19265
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19264
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19267
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19266
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19269
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19268
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19236
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19235
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19234
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19233
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19232
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19231
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19230
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19239
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19237
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19238
type: SequenceSite
position status: EQUAL
sequence position: 1754

http://identifiers.org/pubmed/10853003
type: PublicationXref
id: 10853003
author: Kohler, HP
author: Grant, PJ
db: Pubmed
title: Plasminogen-activator inhibitor type 1 and coronary artery disease
source: N Engl J Med 342:1792-801
year: 2000

SequenceSite19245
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19244
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19247
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19246
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19241
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19240
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19243
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19242
type: SequenceSite
position status: EQUAL
sequence position: 1754

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

Processing of Capped Intron-Containing Pre-mRNA
type: Pathway
data source: Provenance1
pathway component: REACT 261389.1
pathway component: REACT 248934.1
pathway component: REACT 235578.1
evidence: Evidence2465
xref: UnificationXref19691
xref: UnificationXref19692
pathway order: PathwayStep2444
pathway order: PathwayStep2442
pathway order: PathwayStep2447
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

SequenceSite19248
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19249
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15591024
type: PublicationXref
id: 15591024
author: Takano, K
author: Yoshida, M
author: Asai, M
author: Oiso, Y
author: Itoi, K
author: Yamamori, E
author: Iwasaki, Y
db: Pubmed
title: Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
source: J Mol Endocrinol 33:639-49
year: 2004

SequenceSite19210
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19213
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19214
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19211
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19212
type: SequenceSite
position status: EQUAL
sequence position: 1754

K02B12.3
type: ProteinReference
name: UniProt:Q21115
xref: UnificationXref15
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/15591058
type: PublicationXref
id: 15591058
author: Greenspan, DS
author: Zhang, Y
author: Reed, Charles C
author: Gopalakrishnan, Bagavathi
author: Fu, Jian
author: Gonzalez, Eva M
author: Iozzo, Renato V
author: Bix, Gregory
db: Pubmed
title: BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan
source: J. Biol. Chem. 280:7080-7
year: 2005

http://identifiers.org/pubmed/15591059
type: PublicationXref
id: 15591059
author: Wang, Y
author: Muallem, S
author: Shcheynikov, N
author: Kim, KH
db: Pubmed
title: SLC26A7 is a Cl- channel regulated by intracellular pH
source: J Biol Chem 280:6463-70
year: 2005

SequenceSite19218
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19217
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19216
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19215
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19219
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19220
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19221
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19222
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19223
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19224
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19225
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12881521
type: PublicationXref
id: 12881521
author: Tsygankov, A
author: Band, V
author: Band, H
author: Duan, L
author: Rottapel, R
author: Rao, NL
author: Druker, BJ
author: Miura-Shimura, Y
author: Shimura, H
author: Reddi, AL
db: Pubmed
title: Cbl-mediated ubiquitinylation and negative regulation of Vav
source: J Biol Chem 278:38495-504
year: 2003

SequenceSite19227
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19226
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19229
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19228
type: SequenceSite
position status: EQUAL
sequence position: 1754

Tandem pore domain potassium channels
type: Pathway
data source: Provenance1
pathway component: REACT 183270.3
pathway component: REACT 260086.1
pathway component: REACT 183226.3
pathway component: REACT 232219.1
pathway component: TWIK-releated acid-sensitive K+ channel (TASK)
pathway component: Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
evidence: Evidence2082
xref: UnificationXref15837
xref: UnificationXref15838
pathway order: PathwayStep2068
pathway order: PathwayStep2058
pathway order: PathwayStep2062
pathway order: PathwayStep2060
pathway order: PathwayStep2066
pathway order: PathwayStep2064
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

SequenceSite19200
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19201
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19202
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19203
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19209
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19208
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19205
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19204
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19207
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19206
type: SequenceSite
position status: EQUAL
sequence position: 1754

F59A6.5
type: ProteinReference
name: UniProt:Q21025
xref: UnificationXref1634
organism: http://identifiers.org/taxonomy/6239

UniProt:Q21029
type: ProteinReference
name: nsy-1
xref: UnificationXref18597
organism: http://identifiers.org/taxonomy/6239

UniProt:Q2A957
type: ProteinReference
name: him-1
xref: UnificationXref1722
organism: http://identifiers.org/taxonomy/6239

F59B8.2
type: ProteinReference
name: UniProt:Q21032
xref: UnificationXref4893
organism: http://identifiers.org/taxonomy/6239

UniProt:Q21039
type: ProteinReference
name: col-177
xref: UnificationXref28366
organism: http://identifiers.org/taxonomy/6239

F58G4.1
type: ProteinReference
name: UniProt:Q21000
xref: UnificationXref573
organism: http://identifiers.org/taxonomy/6239

nhr-34
type: ProteinReference
name: UniProt:Q21006
xref: UnificationXref27270
organism: http://identifiers.org/taxonomy/6239

F58H1.3
type: ProteinReference
name: UniProt:Q21012
xref: UnificationXref13130
organism: http://identifiers.org/taxonomy/6239

UniProt:Q21067
type: ProteinReference
name: ifc-2
xref: UnificationXref25037
organism: http://identifiers.org/taxonomy/6239

ifa-3
type: ProteinReference
name: UniProt:Q21065
xref: UnificationXref25049
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/17199126
type: PublicationXref
id: 17199126
author: Devreotes, Peter N
author: Franca-Koh, Jonathan
author: Kamimura, Yoichiro
db: Pubmed
title: Leading-edge research: PtdIns(3,4,5)P3 and directed migration
source: Nat. Cell Biol. 9:15-7
year: 2007

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction847
pathway component: BiochemicalReaction848
pathway component: BiochemicalReaction845
pathway component: BiochemicalReaction846
pathway component: BiochemicalReaction843
pathway component: BiochemicalReaction844
pathway component: BiochemicalReaction851
pathway component: BiochemicalReaction850
pathway component: BiochemicalReaction853
pathway component: BiochemicalReaction852
pathway component: BiochemicalReaction855
pathway component: BiochemicalReaction854
pathway component: BiochemicalReaction857
pathway component: BiochemicalReaction856
pathway component: BiochemicalReaction858
pathway component: BiochemicalReaction849
evidence: Evidence1233
xref: UnificationXref9199
xref: RelationshipXref830
xref: UnificationXref9200
pathway order: PathwayStep1220
pathway order: PathwayStep1217
pathway order: PathwayStep1216
pathway order: PathwayStep1215
pathway order: PathwayStep1214
pathway order: PathwayStep1213
pathway order: PathwayStep1212
pathway order: PathwayStep1211
pathway order: PathwayStep1221
pathway order: PathwayStep1222
pathway order: PathwayStep1223
pathway order: PathwayStep1224
pathway order: PathwayStep1225
pathway order: PathwayStep1226
pathway order: PathwayStep1219
pathway order: PathwayStep1218
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

vps-35
type: ProteinReference
name: UniProt:Q21053
xref: UnificationXref7352
organism: http://identifiers.org/taxonomy/6239

UniProt:Q21054
type: ProteinReference
name: cgt-3
xref: UnificationXref10913
organism: http://identifiers.org/taxonomy/6239

Respiratory electron transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1126
pathway component: BiochemicalReaction1125
pathway component: BiochemicalReaction1127
evidence: Evidence1583
xref: UnificationXref11594
xref: UnificationXref11593
xref: RelationshipXref1173
pathway order: PathwayStep1572
pathway order: PathwayStep1574
pathway order: PathwayStep1573
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

tdc-1
type: ProteinReference
name: UniProt:Q21087
xref: UnificationXref12711
organism: http://identifiers.org/taxonomy/6239

K01C8.7
type: ProteinReference
name: UniProt:Q21084
xref: UnificationXref6399
organism: http://identifiers.org/taxonomy/6239

3-Ureidoisobutyrate
type: SmallMoleculeReference
name: 3-ureidoisobutyric acid
name: ChEBI:1670 3-ureidoisobutyric acid
xref: UnificationXref12079

twk-14
type: ProteinReference
name: UniProt:Q21094
xref: UnificationXref15827
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/10371034
type: PublicationXref
id: 10371034
author: Rüegsegger, U
author: Wahle, E
db: Pubmed
title: 3'-End processing of pre-mRNA in eukaryotes.
source: FEMS Microbiol Rev 23:277-95
year: 1999

Glutamate Neurotransmitter Release Cycle
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1423
pathway component: BiochemicalReaction1422
pathway component: BiochemicalReaction1229
evidence: Evidence1962
xref: RelationshipXref1640
xref: UnificationXref14894
xref: UnificationXref14895
pathway order: PathwayStep1691
pathway order: PathwayStep1948
pathway order: PathwayStep1947
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

Gap-filling DNA repair synthesis and ligation in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1995
evidence: Evidence2859
xref: RelationshipXref2235
xref: UnificationXref22577
xref: UnificationXref22578
pathway order: PathwayStep2836
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/21540551
type: PublicationXref
id: 21540551
author: Matejas, V
author: Kispert, A
author: Casarin, A
author: Faul, C
author: Pertegato, V
author: Akman, S
author: Kusakabe, T
author: Wang, S
author: Santos-Ocaña, C
author: Krick, S
author: Doimo, M
author: Hildebrandt, F
author: Chernin, G
author: Vega-Warner, V
author: McLaughlin, HM
author: Nürnberg, G
author: Navas, P
author: Chaki, M
author: Schoeb, DS
author: Becker, C
author: Saisawat, P
author: Heeringa, SF
author: Varpizen, S
author: Prokisch, H
author: Wiggins, RC
author: Nürnberg, P
author: Beissert, A
author: Zhou, W
author: Bakkaloglu, A
author: Ji, Z
author: Xie, LX
author: Hinkes, B
author: Bakkaloglu, SA
author: Salviati, L
author: Reiser, J
author: Vlangos, CN
author: Mir, S
author: Airik, R
author: Topaloglu, R
author: Sloan, AJ
author: Rötig, A
author: Trevisson, E
author: Gbadegesin, R
author: Raphael, Y
author: Zenker, M
author: Clarke, CF
author: Ozaltin, F
author: Soliman, NA
author: Müller, D
author: Berdeli, A
author: Ashraf, S
author: Killen, PD
author: Mundel, P
author: Hurd, TW
author: Giorgi, G
author: Ovunc, B
db: Pubmed
title: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
source: J Clin Invest 121:2013-24
year: 2011

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

UnificationXref18020
type: UnificationXref
id: Q18297
db: UniProt

UnificationXref18021
type: UnificationXref
id: 5649992
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649992

UnificationXref18022
type: UnificationXref
id: G5EE02
db: UniProt

SequenceSite19197
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19196
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19199
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19198
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19193
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18013
type: UnificationXref
id: 5649982
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649982

SequenceSite19192
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref18012
type: UnificationXref
id: 5649981
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649981

SequenceSite19195
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18015
type: UnificationXref
id: 5649984
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649984

SequenceSite19194
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref18014
type: UnificationXref
id: 5649983
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649983

UnificationXref18017
type: UnificationXref
id: 5649986
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649986

UnificationXref18016
type: UnificationXref
id: 5649985
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649985

SequenceSite19191
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18019
type: UnificationXref
id: 5649988
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649988

SequenceSite19190
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref18018
type: UnificationXref
id: 5649987
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649987

http://identifiers.org/pubmed/9536089
type: PublicationXref
id: 9536089
author: Hogenhout, EM
author: Muijsers, AO
author: Caruso, U
author: Ofman, R
author: Hettema, EH
author: Wanders, RJ
db: Pubmed
title: Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2
source: Hum Mol Genet 7:847-53
year: 1998

UnificationXref18010
type: UnificationXref
id: 5649979
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649979

UnificationXref18011
type: UnificationXref
id: 5649980
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649980

UnificationXref18009
type: UnificationXref
id: 5649978
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649978

UnificationXref18004
type: UnificationXref
id: 5649973
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649973

UnificationXref18003
type: UnificationXref
id: 5649972
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649972

UnificationXref18002
type: UnificationXref
id: 5649971
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649971

UnificationXref18001
type: UnificationXref
id: REACT_251936
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251936.1

UnificationXref18008
type: UnificationXref
id: 5649977
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649977

UnificationXref18007
type: UnificationXref
id: 5649976
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649976

UnificationXref18006
type: UnificationXref
id: 5649975
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649975

UnificationXref18005
type: UnificationXref
id: 5649974
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649974

UnificationXref18041
type: UnificationXref
id: 5649996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649996

UnificationXref18042
type: UnificationXref
id: Q8IG05
db: UniProt

UnificationXref18043
type: UnificationXref
id: 5650000
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650000

UnificationXref18044
type: UnificationXref
id: G5ECM4
db: UniProt

UnificationXref18040
type: UnificationXref
id: Q8IG06
db: UniProt

http://identifiers.org/pubmed/18087715
type: PublicationXref
id: 18087715
author: Zhang, H
author: Jia, Q
author: Liu, B
author: Zhao, Z
author: Zhang, G
author: Jia, Z
author: Geng, X
db: Pubmed
title: Molecular basis for genistein-induced inhibition of Kir2.3 currents
source: Pflugers Arch 456:413-23
year: 2008

UnificationXref18039
type: UnificationXref
id: 5633940
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633940

UnificationXref18038
type: UnificationXref
id: 5633939
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633939

UnificationXref18035
type: UnificationXref
id: G5EF09
db: UniProt

UnificationXref18034
type: UnificationXref
id: 5637230
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637230

UnificationXref18037
type: UnificationXref
id: G3MTY7
db: UniProt

UnificationXref18036
type: UnificationXref
id: 5633937
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633937

UnificationXref18032
type: UnificationXref
id: 5637228
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637228

UnificationXref18033
type: UnificationXref
id: 5637229
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637229

UnificationXref18030
type: UnificationXref
id: 5637226
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637226

UnificationXref18031
type: UnificationXref
id: 5637227
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637227

http://identifiers.org/pubmed/23349863
type: PublicationXref
id: 23349863
author: Nguyen, Kevin
author: Raynes, Rachel
author: Mendez, Jamie E
author: Westerheide, Sandy D
author: Pombier, Kathleen M
author: Brunquell, Jessica
db: Pubmed
title: The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
source: PLoS ONE 8:e54364
year: 2013

UnificationXref18029
type: UnificationXref
id: 5637225
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637225

UnificationXref18028
type: UnificationXref
id: 5633933
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5633933

UnificationXref18027
type: UnificationXref
id: P34586
db: UniProt

UnificationXref18026
type: UnificationXref
id: 5637224
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637224

UnificationXref18025
type: UnificationXref
id: 5637223
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637223

UnificationXref18024
type: UnificationXref
id: Q8I6Y9
db: UniProt

UnificationXref18023
type: UnificationXref
id: 5637221
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637221

SequenceSite19150
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19151
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19156
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19157
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19158
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19159
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19152
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19153
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19154
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19155
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16012724
type: PublicationXref
id: 16012724
author: Leoni, VP
author: Giovanazzi, R
author: Ravagnani, F
author: Signoroni, S
author: Dragani, TA
author: Frattini, M
author: Tanuma, J
author: Spinola, M
author: Bertario, L
author: Pettinicchio, A
author: Agresti, R
author: Pilotti, S
db: Pubmed
title: FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
source: Oncol Rep 14:415-9
year: 2005

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

SequenceSite19161
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19162
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19160
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19169
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19167
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19168
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19165
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19166
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19163
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19164
type: SequenceSite
position status: EQUAL
sequence position: 1754

UnificationXref18000
type: UnificationXref
id: 5649338
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649338

SequenceSite19170
type: SequenceSite
position status: EQUAL
sequence position: 1754

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

SequenceSite19171
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19172
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19173
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19174
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19175
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19176
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19177
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

SequenceSite19178
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19179
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/20484404
type: PublicationXref
id: 20484404
author: Cobben, JM
author: van Dijk, FS
author: Pals, G
db: Pubmed
title: Osteogenesis imperfecta, normal collagen folding, and lack of cyclophilin B
source: N Engl J Med 362:1940-1; author reply 1941-2
year: 2010

SequenceSite19180
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19183
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19184
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19181
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19182
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19187
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19188
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19185
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19186
type: SequenceSite
position status: EQUAL
sequence position: 1754

SequenceSite19189
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19115
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19114
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19113
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19112
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19111
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19110
type: SequenceSite
position status: EQUAL
sequence position: 1388

http://identifiers.org/pubmed/7816143
type: PublicationXref
id: 7816143
author: Glover, JN
author: Harrison, SC
db: Pubmed
title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
source: Nature 373:257-61
year: 1995

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

SequenceSite19118
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19119
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19116
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19117
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19124
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19123
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19126
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19125
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19120
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19122
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19121
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18089
type: UnificationXref
id: 5650060
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650060

UnificationXref18092
type: UnificationXref
id: 5650063
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650063

UnificationXref18093
type: UnificationXref
id: 5650064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650064

UnificationXref18094
type: UnificationXref
id: 5650065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650065

UnificationXref18095
type: UnificationXref
id: 5650066
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650066

UnificationXref18096
type: UnificationXref
id: 5650067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650067

UnificationXref18097
type: UnificationXref
id: 5650068
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650068

UnificationXref18098
type: UnificationXref
id: 5650069
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650069

UnificationXref18099
type: UnificationXref
id: 5650070
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650070

http://identifiers.org/pubmed/16965538
type: PublicationXref
id: 16965538
author: Hunt, Donald F
author: Garcia, Benjamin A
author: Shabanowitz, Jeffrey
author: Virshup, David M
author: Klimowski, Laura K
db: Pubmed
title: Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling
source: FEBS J. 273:4594-602
year: 2006

SequenceSite19127
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19128
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19129
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18090
type: UnificationXref
id: 5650061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650061

UnificationXref18091
type: UnificationXref
id: 5650062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650062

SequenceSite19133
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19132
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19131
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19130
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19137
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19136
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19135
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19134
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19138
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19139
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19142
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19141
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19144
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19143
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19146
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19145
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19148
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19147
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19140
type: SequenceSite
position status: EQUAL
sequence position: 1388

hap-1
type: ProteinReference
name: UniProt:Q9GYG4
xref: UnificationXref12303
organism: http://identifiers.org/taxonomy/6239

SequenceSite19149
type: SequenceSite
position status: EQUAL
sequence position: 1212

UnificationXref18058
type: UnificationXref
id: 5650019
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650019

UnificationXref18059
type: UnificationXref
id: 5650020
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650020

UnificationXref18056
type: UnificationXref
id: 5650017
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650017

UnificationXref18057
type: UnificationXref
id: 5650018
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650018

http://identifiers.org/pubmed/16806867
type: PublicationXref
id: 16806867
author: Leitinger, Birgit
author: Kwan, Alvin P L
db: Pubmed
title: The discoidin domain receptor DDR2 is a receptor for type X collagen
source: Matrix Biol. 25:355-64
year: 2006

UnificationXref18062
type: UnificationXref
id: 5650023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650023

UnificationXref18061
type: UnificationXref
id: 5650022
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650022

UnificationXref18060
type: UnificationXref
id: 5650021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650021

UnificationXref18066
type: UnificationXref
id: 5650027
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650027

UnificationXref18065
type: UnificationXref
id: 5650026
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650026

UnificationXref18064
type: UnificationXref
id: 5650025
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650025

UnificationXref18063
type: UnificationXref
id: 5650024
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650024

UnificationXref18045
type: UnificationXref
id: 5650002
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650002

UnificationXref18046
type: UnificationXref
id: Q93971
db: UniProt

UnificationXref18047
type: UnificationXref
id: 5650006
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650006

UnificationXref18048
type: UnificationXref
id: Q20766
db: UniProt

UnificationXref18049
type: UnificationXref
id: 5650008
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650008

UnificationXref18051
type: UnificationXref
id: P34641
db: UniProt

UnificationXref18050
type: UnificationXref
id: 5650009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650009

UnificationXref18053
type: UnificationXref
id: 5650014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650014

UnificationXref18052
type: UnificationXref
id: 5650013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650013

UnificationXref18055
type: UnificationXref
id: 5650016
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650016

UnificationXref18054
type: UnificationXref
id: 5650015
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650015

http://identifiers.org/pubmed/17891149
type: PublicationXref
id: 17891149
author: Fasshauer, D
author: Riedel, D
author: Jahn, Reinhard
author: Radhakrishnan, A
author: Stein, A
db: Pubmed
title: Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
source: Nat Struct Mol Biol 14:904-11
year: 2007

UnificationXref18078
type: UnificationXref
id: G5EBV8
db: UniProt

UnificationXref18079
type: UnificationXref
id: 5650046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650046

UnificationXref18080
type: UnificationXref
id: Q1NZ21
db: UniProt

UnificationXref18088
type: UnificationXref
id: 5650059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650059

Golgi membrane
type: CellularLocationVocabulary
xref: UnificationXref78

UnificationXref18087
type: UnificationXref
id: 5650058
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650058

UnificationXref18086
type: UnificationXref
id: 5650057
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650057

UnificationXref18085
type: UnificationXref
id: 5650056
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650056

UnificationXref18084
type: UnificationXref
id: Q9N3Y9
db: UniProt

UnificationXref18083
type: UnificationXref
id: 5650052
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650052

UnificationXref18082
type: UnificationXref
id: O61220
db: UniProt

UnificationXref18081
type: UnificationXref
id: 5650048
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650048

UnificationXref18067
type: UnificationXref
id: 5650028
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650028

UnificationXref18068
type: UnificationXref
id: 5650029
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650029

UnificationXref18069
type: UnificationXref
id: 5650030
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650030

SequenceSite19100
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19101
type: SequenceSite
position status: EQUAL
sequence position: 1212

TWIK-releated acid-sensitive K+ channel (TASK)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1482
evidence: Evidence2075
xref: UnificationXref15742
xref: UnificationXref15741
pathway order: PathwayStep2061
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

SequenceSite19102
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19103
type: SequenceSite
position status: EQUAL
sequence position: 1212

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

SequenceSite19104
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19106
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19105
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19108
type: SequenceSite
position status: EQUAL
sequence position: 1388

SequenceSite19107
type: SequenceSite
position status: EQUAL
sequence position: 1212

SequenceSite19109
type: SequenceSite
position status: EQUAL
sequence position: 1212

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

UnificationXref18075
type: UnificationXref
id: 5650040
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650040

UnificationXref18074
type: UnificationXref
id: G5EDR9
db: UniProt

UnificationXref18077
type: UnificationXref
id: 5650044
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650044

tre-2
type: ProteinReference
name: UniProt:Q9GYK9
xref: UnificationXref5032
organism: http://identifiers.org/taxonomy/6239

UnificationXref18076
type: UnificationXref
id: Q22374
db: UniProt

UnificationXref18071
type: UnificationXref
id: 5650032
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650032

UnificationXref18070
type: UnificationXref
id: 5650031
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650031

UniProt:Q9GYK4
type: ProteinReference
name: T27F7.1
xref: UnificationXref379
organism: http://identifiers.org/taxonomy/6239

UnificationXref18073
type: UnificationXref
id: 5650036
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650036

Platelet activation, signaling and aggregation
type: Pathway
data source: Provenance1
pathway component: REACT 248761.1
pathway component: REACT 263247.1
pathway component: REACT 233696.1
pathway component: REACT 258791.1
pathway component: REACT 229559.1
pathway component: REACT 229658.1
evidence: Evidence3749
xref: UnificationXref30931
xref: RelationshipXref2554
xref: UnificationXref30932
pathway order: PathwayStep3682
pathway order: PathwayStep3693
pathway order: PathwayStep3691
pathway order: PathwayStep3098
pathway order: PathwayStep3679
pathway order: PathwayStep3707
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref18072
type: UnificationXref
id: G5EGK2
db: UniProt

rps-12
type: ProteinReference
name: UniProt:P49196
xref: UnificationXref20348
organism: http://identifiers.org/taxonomy/6239

rps-21
type: ProteinReference
name: UniProt:P49197
xref: UnificationXref20350
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12671652
type: PublicationXref
id: 12671652
author: Bezakova, Gabriela
author: Ruegg, Markus A
db: Pubmed
title: New insights into the roles of agrin
source: Nat. Rev. Mol. Cell Biol. 4:295-308
year: 2003

elo-3
type: ProteinReference
name: UniProt:P49191
xref: UnificationXref7960
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/17199046
type: PublicationXref
id: 17199046
author: Tamai, K
author: Vidal, Marc
author: Harada, Y
author: Rual, Jean-François
author: Yu, Anan
author: Kirchhausen, Tomas
author: He, Xi
db: Pubmed
title: Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling
source: Dev. Cell 12:129-41
year: 2007

UniProt:P49181
type: ProteinReference
name: rpl-36
xref: UnificationXref20232
organism: http://identifiers.org/taxonomy/6239

rpl-33
type: ProteinReference
name: UniProt:P49180
xref: UnificationXref20291
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9GYQ4
type: ProteinReference
name: gcy-8
xref: UnificationXref4706
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9GYS8
type: ProteinReference
name: frs-1
xref: UnificationXref19805
organism: http://identifiers.org/taxonomy/6239

UniProt:Q9GYS7
type: ProteinReference
name: T08B2.5
xref: UnificationXref19549
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/9914500
type: PublicationXref
id: 9914500
author: di Padova, F
author: Freuler, F
author: Heilker, R
author: Eder, J
author: Pulfer, R
db: Pubmed
title: All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
source: Eur J Biochem 259:253-61
year: 1999

http://identifiers.org/pubmed/10648629
type: PublicationXref
id: 10648629
author: Ong, SH
author: Zhang, Z
author: Falasca, M
author: Rodrigues, GA
author: Schlessinger, J
db: Pubmed
title: A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
source: Mol Cell Biol 20:1448-59
year: 2000

T08B2.7
type: ProteinReference
name: UniProt:Q9GYT0
xref: UnificationXref8213
organism: http://identifiers.org/taxonomy/6239

DCC mediated attractive signaling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction2361
pathway component: BiochemicalReaction2360
pathway component: BiochemicalReaction2362
pathway component: BiochemicalReaction2356
pathway component: BiochemicalReaction2355
pathway component: BiochemicalReaction2354
pathway component: BiochemicalReaction2359
pathway component: BiochemicalReaction2357
pathway component: BiochemicalReaction2358
evidence: Evidence3454
xref: UnificationXref26431
xref: UnificationXref26432
pathway order: PathwayStep3418
pathway order: PathwayStep3419
pathway order: PathwayStep3420
pathway order: PathwayStep3412
pathway order: PathwayStep3413
pathway order: PathwayStep3416
pathway order: PathwayStep3417
pathway order: PathwayStep3414
pathway order: PathwayStep3415
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12438653
type: PublicationXref
id: 12438653
author: Rosenblatt, DS
author: Wilson, Aaron
author: Leclerc, Daniel
author: Doré, Carole
author: Wu, Xuchu
author: Hudson, Thomas
author: Dobson, C Melissa
author: Gravel, RA
author: Wai, Timothy
db: Pubmed
title: Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
source: Proc. Natl. Acad. Sci. U.S.A. 99:15554-9
year: 2002

http://identifiers.org/pubmed/5046811
type: PublicationXref
id: 5046811
author: Kishida, Y
author: Prockop, DJ
author: Kivirikko, KI
author: Sakakibara, S
db: Pubmed
title: Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate
source: Biochim Biophys Acta 271:347-56
year: 1972

Sialic acid metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1529
pathway component: BiochemicalReaction1586
evidence: Evidence2668
xref: UnificationXref21416
xref: UnificationXref21415
pathway order: PathwayStep2125
pathway order: PathwayStep2200
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/12671646
type: PublicationXref
id: 12671646
author: Chao, MV
db: Pubmed
title: Neurotrophins and their receptors: a convergence point for many signalling pathways
source: Nat Rev Neurosci 4:299-309
year: 2003

http://identifiers.org/pubmed/18760361
type: PublicationXref
id: 18760361
author: Maness, PF
author: Schmid, RS
db: Pubmed
title: L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
source: Curr Opin Neurobiol 18:245-50
year: 2008

Evidence1774
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12477380
comment: Acetylated spermidine is oxidized by the flavoenzyme polyamine oxidase (PAO) to produce putrescine. PAO is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations.

Evidence1775
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1985966
xref: http://identifiers.org/pubmed/15784477
comment: Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Evidence1776
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12477380
comment: Acetylated spermine is oxidized by the flavoenzyme polyamine oxidase (PAO) to produce spermidine. PAO is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations.

Evidence1777
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12141946
xref: http://identifiers.org/pubmed/11454677
xref: http://identifiers.org/pubmed/12727196
comment: Spermine oxidase (SMOX/PAOh1/SMO) is a polyamine oxidase flavoenzyme which catalyzes the oxidation of spermine to spermidine. It plays an important role in the regulation of endogenous polyamine intracellular concentration. Five different isozymes are produced by alternative splicing with isozyme 3 being the major isoform and possessing the highest affinity for spermine. It is highly inducible by specific antitumor polyamine analogues (Wang et al., 2001).

Evidence1778
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11564948
xref: http://identifiers.org/pubmed/15784477
xref: http://identifiers.org/pubmed/15221502
xref: http://identifiers.org/pubmed/12686127
comment: The reactions catalyzed by aminopropyl-transferases annotated above are generally irreversible. But spermine and spermidine can be recycled respectively into spermidine and putrescine. These events require the formation of N-acetylated intermediates, N1-acetylspermine and N1-acetylspermidine catalyzed by a cytosolic acetyl-CoA:spermidine/spermine N1-acetyl-tranferase (SSAT) enzyme. Subsequently, polyamine-oxidase (PAO), a FAD enzyme present in the peroxysomes, yields a polyamine with release of an aldehyde (3-acetamindopropanal) and H2O2. In addition, SMOX, a FAD-dependent, polyamine oxidase (PAOh1/SMO) that can efficiently use spermine as a substrate and is involved in interconversion reactions.

Evidence1779
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3091600
xref: http://identifiers.org/pubmed/22464254
xref: http://identifiers.org/pubmed/6785752
comment: MTA phosphorylase catalyzes the cleavage of adenine from S-methylthioadenosine (MTA) and subsequent phosphorylation of the product, yielding 5'-methylthio ribose-1-phosphate (Kamatani et al. 1981). The active form of the enzyme is a homotrimer (Della Ragione et al. 1985). Mutations in the gene are associated with a rare bone dysplasia and cancer syndrome, DMS-MFH (Camacho-Vanegas et al. 2012).

RelationshipXref207
type: RelationshipXref
id: 5639991
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639991

RelationshipXref208
type: RelationshipXref
id: 5643705
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643705

RelationshipXref209
type: RelationshipXref
id: 5643093
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643093

RelationshipXref204
type: RelationshipXref
id: GO:0004707
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref203
type: RelationshipXref
id: 5640066
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640066

RelationshipXref206
type: RelationshipXref
id: 5640061
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640061

RelationshipXref205
type: RelationshipXref
id: 5640064
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640064

RelationshipXref200
type: RelationshipXref
id: 5640056
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640056

RelationshipXref202
type: RelationshipXref
id: 5640010
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640010

RelationshipXref201
type: RelationshipXref
id: 5640054
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640054

Evidence1771
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10029540
xref: http://identifiers.org/pubmed/11583147
comment: S-Adenosylmethionine decarboxylase belongs to a small class of amino acid decarboxylases that use a covalently bound pyruvate as a prosthetic group. It is an essential enzyme for polyamine biosynthesis and provides an important target for the design of anti-parasitic and cancer chemotherapeutic agents. It catalyzes the formation of the aminopropyl group donor in the biosynthesis of the polyamines spermidine and spermine. These pyruvoyl-dependent decarboxylases also form amines such as histamine, decarboxylated S-adenosylmethionine, phosphatidylethanolamine (a component of membrane phospholipids), and -alanine (a precursor of coenzyme A), which are all of critical importance in cellular physiology and provide important targets for drug design.

Evidence1770
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2785
comment: L-ornithine is converted into putrescine by ODC holoenzyme complex.Putrescine is subsequent used for polyamine synthesis.

Evidence1773
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1985966
xref: http://identifiers.org/pubmed/8360194
comment: Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Evidence1772
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2069720
comment: Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

Evidence1787
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11564948
xref: http://identifiers.org/pubmed/15784477
xref: http://identifiers.org/pubmed/12686127
comment: Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

RelationshipXref2191
type: RelationshipXref
id: GO:0006493
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1788
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8101641
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/2575455
comment: Tyrosine hydroxylase (TH) is the first enzyme in catecholamine biosynthesis, as well as being the rate-limiting enzyme in that process. TH requires tetrahydrobiopterin and uses iron as a cofactor in the 3,4-hydroxylation of tyrosine to produce dopa. Four isoforms of TH are expressed in the human brain and all have enzymatic activity (Nagatsu, T, 1989; Lewis, DA et al, 1993).

RelationshipXref2192
type: RelationshipXref
id: GO:0070139
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1785
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11443076
comment: In the last step MOB gets transaminated to methionine. The reaction was confirmed in yeast, where several transaminases catalyze it, which appears to be also the case in rat. At the moment, the human enzymes involved are unknown but due to homology to the respective enzyme in the parasite Crithidia fasciculata we feel supported to state that human GOT is probably one of the involved transaminases. (Berger et al, 2001)

RelationshipXref2193
type: RelationshipXref
id: 5649403
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649403

Evidence1786
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18625006
xref: http://identifiers.org/pubmed/19946895
comment: Methionine salvage is a sequential pathway of six reactions that create methionine from 5'-methylthioadenosine (MTA) which is a byproduct of polyamine biosynthesis in nearly all organisms. The process happens completely in the cytosol. It is important in humans for recycling of sulphur that has to be assimilated using energy. (Pirkov et al, 2008; Albers, 2009)

RelationshipXref2194
type: RelationshipXref
id: GO:0016925
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2195
type: RelationshipXref
id: GO:0019948
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2196
type: RelationshipXref
id: 5649394
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649394

Evidence1789
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/1540578
xref: http://identifiers.org/pubmed/2590185
comment: Aromatic L-amino acid decarboxylase (AADC, dopa decarboxylase) decarboxylates dopa to form dopamine.

RelationshipXref2197
type: RelationshipXref
id: 5649432
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649432

RelationshipXref2198
type: RelationshipXref
id: GO:0032977
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2199
type: RelationshipXref
id: 5639983
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639983

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

Evidence1780
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19620624
comment: Equilibrium between 5'-methylthio ribose-1-phosphate and 5'-methylthio ribulose-1-phosphate is catalyzed by 5'-methylthio ribose-1-phosphate isomerase. (Kabuyama et al, 2009)

ncs-2
type: ProteinReference
name: UniProt:P36609
xref: UnificationXref4675
organism: http://identifiers.org/taxonomy/6239

Evidence1784
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17786183
comment: Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)

Evidence1783
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15843022
comment: Acireductone synthase (also: enolase-phosphatase E1) catalyzes the dephosphorylation and conversion to enolate of 2,3-dioxo-5'-methylthiopentane-1-phosphate, yielding acireductone. (Wang et al, 2005)

Evidence1782
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The human enzyme with 5'-methylthio ribulose-1-phosphate isomerase activity is probably produced from the APIP gene, according to its orthology with the yeast Mde1p enzyme.

Evidence1781
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19620624
comment: Equilibrium between 5'-methylthio ribose-1-phosphate and 5'-methylthio ribulose-1-phosphate is catalyzed by 5'-methylthio ribose-1-phosphate isomerase. (Kabuyama et al, 2009)

Evidence1756
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1772073
comment: Tryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EGG8
data source: Provenance1
name: HsRAD51
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: G5EGG8
name: hRAD51
xref: UnificationXref22497
feature: FragmentFeature5703
cellular location: GO_0005654
comment: Reactome DB_ID: 5623179
display name: RAD51

Evidence1757
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12807890
xref: http://identifiers.org/pubmed/12948741
xref: http://identifiers.org/pubmed/10369256
comment: The mitochondrial ornithine transporters SLC25A15 and SLC25A2 mediate the exchange of cytosolic ornithine for citrulline from the mitochondrial matrix. SLC25A15 was the first protein shown to have this function, identified because mutations in the protein are associated with elevated levels of ammonia, ornithine, and citrulline in affected individuals (Camacho et al. 1999). The second transporter, SLC25A2, identified later, is also expressed in normal cells and their apparently partly redundant function may explain the relatively mild symptoms associated with SLC25A15 deficiency compared to other defects of the urea cycle (Fiermonte et al. 2003).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q95Q25
data source: Provenance1
name: HsRAD51
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: hRAD51
name: Q95Q25
xref: UnificationXref22495
feature: FragmentFeature5702
cellular location: GO_0005654
comment: Reactome DB_ID: 5623177
display name: RAD51

Evidence1758
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2875
comment: The urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of ornithine and carbamoyl phosphate to form citrulline, of citrulline and aspartate to form argininosuccinate, the cleavage of argininosuccinate to yield fumarate and arginine, and the cleavage of arginine to yield urea and re-form ornithine. The carbamoyl phosphate consumed in this cycle is synthesized in the mitochondria from bicarbonate and ammonia, and this synthesis in turn is dependent on the presence of N-acetylglutamate, which allosterically activates carbamoyl synthetase I enzyme. The synthesis of N-acetylglutamate is stimulated by high levels of arginine. Increased levels of free amino acids, indicated by elevated arginine levels, thus stimulate urea synthesis. Two enzymes catalyze the hydrolysis of arginine to yield ornithine and urea. Cytosolic ARG1 is the canonical urea cycle enzyme. Mitochondrial ARG2 likewise catalyzes urea production from arginine and may have a substantial sparing effect in patients lacking ARG1 enzyme, so its reaction is annotated here although the role of ARG2 under normal physiological conditions remains unclear.

Evidence1759
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11431483
comment: Trimethyllysine dioxygenase dimer (TMLHE) in the mitochondrial matrix catalyzes the reaction of oxygen, 2-oxoglutarate, and 'N6,N6,N6-Trimethyl-L-lysine to form CO2, 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine, and succinate (Vaz et al. 2001).

Evidence1752
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10672018
comment: Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.

Evidence1753
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9180257
comment: Cytosolic kynureninase catalyzes the hydrolysis of 3-hydroxy-L-kynurenine to form L-alanine and 3-hydroxyanthranilate.

Evidence1754
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7514594
comment: Cytosolic 3-hydroxyanthranilate oxygenase catalyzes the reaction of 3-hydroxyanthranilate and O2 to form 2-amino-3-carboxymuconate semialdehyde.

Evidence1755
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12140278
comment: At the beginning of this reaction, 1 molecule of '2-Amino-3-carboxymuconate semialdehyde' is present. At the end of this reaction, 1 molecule of 'CO2', and 1 molecule of '2-Aminomuconate semialdehyde' are present. This reaction takes place in the 'cytoplasm' and is mediated by the 'carboxy-lyase activity' of '2-amino-3-carboxymuconate-6-semialdehyde decarboxylase homodimer'.

RelationshipXref229
type: RelationshipXref
id: 5645828
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645828

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q2HQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MGMT containing S-methyl-L-cysteine
name: Methylated-DNA--protein-cysteine methyltransferase
name: MetC-MGMT
xref: UnificationXref22461
feature: ModificationFeature1188
feature: FragmentFeature5696
cellular location: GO_0005654
comment: Reactome DB_ID: 5621915
display name: Q2HQK2

Homologues of MetC-MGMT
type: Protein
data source: Provenance1
member physical entity: 6-O- methylguanine-DNA methyltransferase
xref: UnificationXref22463
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5621918

http://identifiers.org/pubmed/8562305
type: PublicationXref
id: 8562305
author: Degerman, E
author: Belfrage, P
author: Manganiello, VC
author: Taira, M
db: Pubmed
title: Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
source: Cell Signal 7:445-55
year: 1995

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference189
data source: Provenance1
name: Ataxia telangiectasia mutated
name: Y48G1BL.2
name: Serine-protein kinase ATM
name: A-T, mutated
name: ATM serine-protein kinase
name: Serine-protein kinase ATM (EC 2.7.1.37) (Ataxia telangiectasia mutated) (A-T, mutated)
xref: UnificationXref22470
feature: FragmentFeature5698
cellular location: GO_0005654
comment: Reactome DB_ID: 5622589
display name: ATM

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q9U1Y0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MGMT containing S-methyl-L-cysteine
name: Methylated-DNA--protein-cysteine methyltransferase
name: MetC-MGMT
xref: UnificationXref22462
feature: FragmentFeature5697
feature: ModificationFeature1189
cellular location: GO_0005654
comment: Reactome DB_ID: 5621917
display name: Q9U1Y0

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O44199
data source: Provenance1
name: O44199
xref: UnificationXref22482
feature: FragmentFeature5700
cellular location: GO_0005654
comment: Reactome DB_ID: 5622596
display name: RAD50

MRE11 homolog 1
type: Protein
entity reference: Q23255
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q23255
name: Double-strand break repair protein MRE11A
xref: UnificationXref22480
feature: FragmentFeature5699
cellular location: GO_0005654
comment: Reactome DB_ID: 5622600
display name: MRE11A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XTK2
data source: Provenance1
name: HsRAD51
name: Q9XTK2
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: hRAD51
xref: UnificationXref22493
feature: FragmentFeature5701
cellular location: GO_0005654
comment: Reactome DB_ID: 5623175
display name: RAD51

Homologues of RAD51
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22498
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5623180

RelationshipXref222
type: RelationshipXref
id: 5645203
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645203

RelationshipXref221
type: RelationshipXref
id: 5645717
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645717

RelationshipXref224
type: RelationshipXref
id: 5645224
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645224

RelationshipXref223
type: RelationshipXref
id: 5645728
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645728

RelationshipXref226
type: RelationshipXref
id: 5643809
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643809

RelationshipXref225
type: RelationshipXref
id: 5645735
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645735

RelationshipXref228
type: RelationshipXref
id: 5643818
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643818

RelationshipXref227
type: RelationshipXref
id: 5643813
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643813

Evidence1751
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16376499
comment: CCBL2 (KAT 3) catalyzes the reaction of kynurenine and pyruvate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and alanine. CCBL2 is known only as the predicted protein product of a cloned human gene closely homologous to CCBL1 (Yu et al. 2006) and all of the structural and catalytic properties annotated here are inferred from those of CCBL1.

Evidence1750
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12007602
comment: Cytosolic arylformamidase (AFMID) catalyzes the hydrolysis of formylkynurenine to yield formate and L-kynurenine. Human AFMID has been identified only as an open reading frame; its activity is inferred from that of its well-characterized mouse homologue (Pabarcus and Casida 2002).

RelationshipXref220
type: RelationshipXref
id: 5645217
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645217

Evidence1769
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17025265
xref: http://identifiers.org/pubmed/15784477
xref: http://identifiers.org/pubmed/15028568
xref: http://identifiers.org/pubmed/15028567
comment: Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator (Reghunathan 2006). Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Satriano, 2003).

Evidence1767
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14738999
comment: Agmatine is polyamine formed by decarboxylation of L-arginine by arginine decarboxylase (ADC). Human ADC is a 460-amino acid protein that shows about 48% identity to mammalian ornithine decarboxylase (ODC) but has no ODC activity.

Evidence1768
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11804860
xref: http://identifiers.org/pubmed/11914032
xref: http://identifiers.org/pubmed/15028567
comment: As it hydrolyzes a guanidino group within agmatine and also contains signature amino acid residues that act as ligand binding sites for the potential Mn(++) cofactor, agmatinase is classified as a member of the arginase superfamily (Morris, 2003).

Q9N3T8
type: Protein
entity reference: Q9N3T8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA mismatch repair protein Msh6
name: MSH6_HUMAN
xref: UnificationXref22626
feature: FragmentFeature5713
cellular location: GO_0005654
comment: Reactome DB_ID: 5652354
display name: MSH6

Evidence1765
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9722522
xref: http://identifiers.org/pubmed/2324105
xref: http://identifiers.org/pubmed/15044463
xref: http://identifiers.org/pubmed/2914937
comment: Creatine kinase octamers associated with the inner mitochondrial membrane catalyze the reaction of creatine and ATP to form phosphocreatine and ADP. Two mitochondrial creatine kinase proteins have been identified, one encoded by CKMT1A and B that is found in many tissues and one encoded by CKMT2 that is found in sarcomeres (Haas et al. 1988; Haas and Straus 1990). Studies of sarcomeric creatine kinase octamers suggest that their organization and association with phospholipids in the inner mitochondrial membrane may facilitate energy transfer from ATP generated in the mitochondrial matrix to cytosolic phosphocreatine (Khuchua et al. 1998; Schlattner et al. 2004).

Evidence1766
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9706223
xref: http://identifiers.org/pubmed/10893433
comment: In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter. Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

Evidence1763
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9706223
comment: Carnitine is synthesized in four steps from trimethyllysine (generated in turn by the S-adenosyl-methionine-mediated methylation of lysine residues in proteins, followed by protein hydrolysis). The enzymes that catalyze the first three steps of carnitine synthesis, converting trimethyllysine to gamma-butyrobetaine, are widely distributed in human tissues. The enzyme that catalyzes the last reaction, converting gamma-butyrobetaine to carnitine, is found only in liver and kidney cells, and at very low levels in brain tissues. Other tissues that require carnitine, such as muscle, are dependent on transport systems that mediate its export from the liver and uptake by other tissues (Kerner and Hoppel 1998).

Evidence1764
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16981706
comment: Cytosolic creatine kinase catalyzes the reaction of creatine and ATP to form phosphocreatine and ADP. The active form of the enzyme is a dimer. Monomers of the cytosolic enzyme occur in two isoforms, B and M, so called because of their abundance in brain and muscle respectively. The enzyme is widely expressed in the body and many tissues express both isoforms. Both homo- (BB, MM) and heterodimers (BM) are catalytically active.

Q21302
type: Protein
entity reference: Q21302
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-repair protein complementing XP-A cells
name: xeroderma pigmentosum, complementation group A
name: Xeroderma pigmentosum group A complementing protein
name: DNA-repair protein complementing XP-A cells (Xeroderma pigmentosum group A complementing protein)
name: XPA protein
xref: UnificationXref22543
feature: FragmentFeature5708
cellular location: GO_0005654
comment: Reactome DB_ID: 5621941
display name: XPA

DDB1, DNA damage binding protein 1
type: Protein
entity reference: Q21554
data source: Provenance1
name: DNA damage binding protein 1
name: Q21554
name: XAP-1
name: Damage-specific DNA binding protein 1
name: DDB p127 subunit
name: DDBa
name: Note: the coordinates are copied over from Homo sapiens.
name: Xeroderma pigmentosum group E complementing protein
name: X- associated protein 1
name: UV-damaged DNA-binding protein 1
name: XPCe
name: UV-DDB 1
xref: UnificationXref22541
feature: FragmentFeature5707
cellular location: GO_0005654
comment: Reactome DB_ID: 5621995
display name: DDB1

RelationshipXref218
type: RelationshipXref
id: 5645723
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645723

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O44737
data source: Provenance1
name: DNA excision repair protein ERCC-5
name: DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G complementing protein) (DNA excision repair protein ERCC-5)
name: Xeroderma pigmentosum group G complementing protein
name: DNA-repair protein complementing XP-G cells
name: ERCC5 or XPGC
name: O44737
name: XPG protein
xref: UnificationXref22539
feature: FragmentFeature5706
cellular location: GO_0005654
comment: Reactome DB_ID: 5621945
display name: ERCC5

RelationshipXref219
type: RelationshipXref
id: 5645670
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645670

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q23451
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: HHR23B
name: Q23451
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref22529
feature: FragmentFeature5705
cellular location: GO_0005654
comment: Reactome DB_ID: 5621931
display name: P58

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9TXR4
data source: Provenance1
name: Q9TXR4
name: DNA mismatch repair protein Msh2
name: MSH2_HUMAN
xref: UnificationXref22624
feature: FragmentFeature5712
cellular location: GO_0005654
comment: Reactome DB_ID: 5652350
display name: MSH2

P91175
type: Protein
entity reference: P91175
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HCNP protein
name: PP3898
name: XPA-binding protein 2
xref: UnificationXref22591
feature: FragmentFeature5711
cellular location: GO_0005654
comment: Reactome DB_ID: 5623571
display name: XAB2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EBZ1
data source: Provenance1
name: G5EBZ1
name: XPF protein
name: DNA excision repair protein ERCC-4
name: DNA-repair protein complementing XP-F cell
name: DNA-repair protein complementing XP-F cell (Xeroderma pigmentosum group F complementing protein) (DNA excision repair protein ERCC-4)
name: Xeroderma pigmentosum group F complementing protein
xref: UnificationXref22553
feature: FragmentFeature5710
cellular location: GO_0005654
comment: Reactome DB_ID: 5622007
display name: ERCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93456
data source: Provenance1
name: ERCC1, DNA excision repair protein
name: Q93456
name: DNA excision repair protein ERCC-1
xref: UnificationXref22551
feature: FragmentFeature5709
cellular location: GO_0005654
comment: Reactome DB_ID: 5622003
display name: ERCC1

RelationshipXref213
type: RelationshipXref
id: 5645362
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645362

RelationshipXref212
type: RelationshipXref
id: 5643107
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643107

RelationshipXref211
type: RelationshipXref
id: 5643099
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643099

RelationshipXref210
type: RelationshipXref
id: 5643104
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643104

RelationshipXref217
type: RelationshipXref
id: 5645719
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645719

RelationshipXref216
type: RelationshipXref
id: 5645721
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645721

Q9N4C3
type: Protein
entity reference: Q9N4C3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: XPC protein
name: xeroderma pigmentosum, complementation group C
name: Xeroderma pigmentosum group C complementing protein
name: DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C complementing protein) (P125)
name: p125
name: DNA-repair protein complementing XP-C cells
xref: UnificationXref22527
feature: FragmentFeature5704
cellular location: GO_0005654
comment: Reactome DB_ID: 5621935
display name: XPC

RelationshipXref215
type: RelationshipXref
id: 5645663
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645663

RelationshipXref214
type: RelationshipXref
id: 5645371
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645371

Evidence1762
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6497835
xref: http://identifiers.org/pubmed/9753662
comment: Cytosolic gamma-butyrobetaine hydroxylase dimer (BBOX1) catalyzes the reaction of oxygen, 4-trimethylammoniobutanoate, and 2-oxoglutarate to form C)2, succinate, and carnitine (Lindstedt and Nordin 1984; Vaz et al. 1998).

Evidence1761
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10702312
xref: http://identifiers.org/pubmed/2925663
comment: Cytosolic 4-trimethylaminobutyraldehyde dehydrogenase tetramer (ALDH9A1) catalyzes the reaction of NAD+', and 4-trimethylammoniobutanal to form 4-Trimethylammoniobutanoate and NADH + H+ (Kurys et al. 1989; Vaz et al. 2000).

Evidence1760
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/627563
comment: Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) catalyzes the reaction of 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine to form glycine and 4-trimethylammoniobutanal (Hulse et al. 1978).

Evidence1739
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2852
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

Evidence1738
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8262916
xref: http://identifiers.org/pubmed/3033643
comment: Cytosolic dihydropteridine reductase (QDPR) catalyzes the reaction of q-dihydrobiopterin with NADH + H+to form tetrahydrobiopterin and NAD+. The enzyme is a homodimer (Lockyer et al. 1987; Su et al. 1993).

Evidence1731
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19885858
xref: http://identifiers.org/pubmed/16491085
comment: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

Evidence1730
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6434529
xref: http://identifiers.org/pubmed/10775527
comment: The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of saccharopine (N6-(L-1,3-Dicarboxypropyl)-L-lysine), H2O, and NAD+ to form 'L-2-Aminoadipate 6-semialdehyde, glutamate, and NADH + H+ (Markovitz et al. 1984; Sacksteder et al. 2001).

Evidence1733
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11752427
xref: http://identifiers.org/pubmed/9727038
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/2188967
comment: The mitochondrial alpha-ketoglutarate dehydrogenase complex catalyzes the reaction of alpha-ketoadipate, CoASH, and NAD+ to form glutaryl-CoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 (OGDH), E2 (DLST), and E3 (DLD), each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of alpha-ketoadipate catalyzed by E1alpha and beta (alpha ketoglutarate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the glutaryl group derived from alpha ketoglutarate is transferred to coenzyme A in two steps catalyzed E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with alpha ketoglutarate dehydrogenase complex and subunits purified from bovine tissue (McCartney et al. 1998). While all of the human proteins are known as predicted protein products of cloned genes, direct experimental evidence for their functions is available only for E3 (DLD) (Brautigam et al. 2005).

Evidence1732
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11083877
comment: SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. While the exchange is reversible, under physiological conditions it proceeds in the direction of 2-oxoadipate import into the mitochondrial matrix and 2-oxoglutarate export (Fiermonte et al. 2001).

Evidence1735
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6434529
xref: http://identifiers.org/pubmed/12126930
xref: PublicationXref2846
xref: PublicationXref2844
comment: In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).

Evidence1734
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18775954
xref: http://identifiers.org/pubmed/15274622
comment: Mitochondrial glutaryl-CoA dehydrogenase (GCDH) catalyzes the reaction of glutaryl-CoA and FAD to form crotonyl-CoA, FADH2, and CO2. The active enzyme is a tetramer of GCDH polypeptides lacking a 44-residue aminoterminal mitochondrial targeting sequence. Mutations in GCDH cause glutaric aciduria type 1 in vivo (Fu et al. 2004; Keyser et al. 2008).

Evidence1737
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8352282
xref: http://identifiers.org/pubmed/7744010
xref: http://identifiers.org/pubmed/8444860
comment: Cytosolic pterin-4-alpha-carbinolamine dehydratase (PCDB1) catalyzes the reaction of 4a-hydroxytetrahydrobiopterin to form q-dihydrobiopterin and water (Hauer et al. 1993. The active enzyme is a homotetramer (Ficner et al. 1995); mutations in the PCDB1 gene are associated with mild hyperphenylalanemia in vivo (Citron et al. 1993).

Evidence1736
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7883047
xref: http://identifiers.org/pubmed/19338303
xref: http://identifiers.org/pubmed/8294935
xref: http://identifiers.org/pubmed/15364907
comment: CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

RelationshipXref240
type: RelationshipXref
id: GO:0030213
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref241
type: RelationshipXref
id: GO:0004415
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref242
type: RelationshipXref
id: 5646471
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5646471

RelationshipXref247
type: RelationshipXref
id: 5641927
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5641927

RelationshipXref248
type: RelationshipXref
id: GO:0030214
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/24695224
type: PublicationXref
id: 24695224
author: Sanjiv, Kumar
author: Gustafsson, Robert
author: Kalderén, Christina
author: Gustavsson, Anna-Lena
author: Svensson, Richard
author: Loseva, Olga
author: Olofsson, Roger
author: Pham, Therese
author: Granelli, Ingrid
author: Ström, Cecilia E
author: Baranczewski, Pawel
author: Wiita, Elisee
author: Koolmeister, Tobias
author: Häggblad, Maria
author: Wallner, Olov A
author: Berntsson, Ronnie P-A
author: Höglund, Andreas
author: Hagenkort, Anna
author: Schultz, Niklas
author: Johansson, Lars
author: Gad, Helge
author: Johansson, Fredrik
author: Bräutigam, Lars
author: Svensson, Linda M
author: Göktürk, Camilla
author: Martens, Ulf
author: Jemth, Ann-Sofie
author: Axelsson, Hanna
author: Vikingsson, Svante
author: Artursson, Per
author: Hammarström, Lars G J
author: Saleh, Aljona
author: Homan, Evert J
author: Lundbäck, Thomas
author: Henriksson, Martin
author: Lundgren, Bo
author: Vallin, Karl S A
author: Helleday, Thomas
author: Stenmark, Pål
author: Puigvert, Jordi Carreras
author: Jacques-Cordonnier, Marie-Caroline
author: Strömberg, Kia
author: Lundin, Cecilia
author: Jeppsson, Fredrik
author: Desroses, Matthieu
author: Almlöf, Ingrid
author: Altun, Mikael
author: Jensen, Annika Jenmalm
author: Djureinovic, Tatjana
author: Evers, Bastiaan
author: Einarsdottir, Berglind Osk
author: Scobie, Martin
author: Gaugaz, Fabienne Z
author: Jacques, Sylvain A
author: Nilsson, Jonas A
author: Berglund, Ulrika Warpman
author: Eshtad, Saeed
db: Pubmed
title: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
source: Nature 508:215-21
year: 2014

RelationshipXref249
type: RelationshipXref
id: GO:0030212
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref243
type: RelationshipXref
id: 5642966
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5642966

http://identifiers.org/pubmed/24695225
type: PublicationXref
id: 24695225
author: Bennett, Keiryn L
author: Sanjiv, Kumar
author: Radic, Branka
author: Helleday, Thomas
author: Loizou, Joanna I
author: Stukalov, Alexey
author: Knapp, Stefan
author: Elkins, JM
author: Göktürk, Camilla
author: Salah, Eidarus
author: Pham, Therese
author: Jemth, Ann-Sofie
author: Colinge, Jacques
author: Strömberg, Kia
author: Berglund, Ulrika Warpman
author: Huber, Kilian V M
author: Superti-Furga, Giulio
author: Gridling, Manuela
db: Pubmed
title: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
source: Nature 508:222-7
year: 2014

RelationshipXref244
type: RelationshipXref
id: GO:0004566
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref245
type: RelationshipXref
id: 5642671
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5642671

RelationshipXref246
type: RelationshipXref
id: GO:0004563
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

Evidence1749
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1907934
xref: http://identifiers.org/pubmed/11469796
xref: http://identifiers.org/pubmed/8666386
comment: Cytosolic tryptophan 2,3-dioxygenase (TDO) tetramer catalyzes the conversion of L-tryptophan and oxygen to formylkynurenine. The structure and catalytic properties of the human enzyme are inferred from the close similarity of its predicted amino acid sequence (Comings et al. 1995) to that of the well-studied rat enzyme (Dick et al. 2001). In the body, TDO is found predominantly in the liver and is induced by metabolites such as tryptophan and histidine, and by glucocorticoids. These properties, together with TDO's narrow substrate specificity, are consistent with the hypothesis that the enzyme functions functions primarily in tryptophan catabolism and NAD biosynthesis (Taylor and Feng 1991).

http://identifiers.org/pubmed/10548110
type: PublicationXref
id: 10548110
author: Lukas, J
author: Kramer, E
author: Peters, JM
author: Lindeneg, C
author: Santoni-Rugiu, E
author: Sorensen, CS
author: Lukas, C
db: Pubmed
title: Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
source: Nature 401:815-8
year: 1999

Evidence1744
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8364576
comment: Cytosolic fumarylacetoacetase catalyzes the hydrolysis of 4-fumarylacetoacetate to form fumarate and acetoacetate (Labelle et al. 1993).

Evidence1743
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11327815
comment: Cytosolic maleylacetoacetic acid isomerase (GSTZ1) catalyzes the conversion of 4-maleylacetoacetate to 4-fumarylacetoacetate. The enzyme is a homodimer (Polekhina et al. 2001).

Evidence1742
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8782815
xref: http://identifiers.org/pubmed/10876237
comment: Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the reaction of homogentisate and molecular oxygen to form 4-maleylacetoacetate. The activity of human HGD is inferred from the phenotype of alkaptonuria patients, in whom HGD activity is defective (Fernandez-Canon et al. 1996). HGD is a homohexamer (Titus et al. 2000).

Evidence1741
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10942115
comment: Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD) catalyzes the reaction of 3-(4-Hydroxyphenyl)pyruvate with molecular oxygen to form homogentisate and CO2 (Ruetschi et al. 2000). Unpublished crystallographic data indicate that the enzyme is a homodimer (PDB 3ISQ).

Evidence1748
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2792
comment: Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001).

Evidence1747
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9700195
xref: http://identifiers.org/pubmed/3944130
xref: http://identifiers.org/pubmed/8621661
comment: Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the reaction of L-glutamate gamma-semialdehyde and NAD+ to form glutamate and NADH + H+ (Hu et al. 1996). The enzyme is a dimer (Forte-McRobbie and Pietruszko 1986). ALDH4A1 mutations cause type II hyperprolinemia in vivo (Geraghty et al. 1998).

Evidence1746
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15662599
comment: The dehydrogenation of proline to L-1-pyrroline-5-carboxylate coupled to the conversion of FAD to FADH2 is the first step in proline breakdown (Bender et al. 2005). Proline dehydrogenase (PRODH), the enzyme that catalyzes this reaction, is found in liver, kidney, and brain cells, where it is tightly bound to the inner mitochondrial membrane.

Evidence1745
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2852
xref: PublicationXref761
comment: The first reaction in this pathway converts phenylalanine to tyrosine, coupled to the conversion of tetrahydrobiopterin to 4a-hydroxytetrahydrobiopterin, catalyzed by phenylalanine hydroxylase. (Deficiencies in this enzyme are responsible for the commonest form of phenylketonuria (PKU) in humans.) This reaction functions both as the first step in the pathway by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine. The next two reactions are responsible for the regeneration of tetrahydrobiopterin from 4a-hydroxytetrahydrobiopterin. The following five reactions convert tyrosine to fumarate, an intermediate in the citric acid cycle, and acetoacetate, a ketone body.

RelationshipXref230
type: RelationshipXref
id: GO:0004505
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref231
type: RelationshipXref
id: 5619992
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619992

Evidence1740
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2852
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

RelationshipXref238
type: RelationshipXref
id: GO:0008514
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref239
type: RelationshipXref
id: 5646119
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5646119

RelationshipXref236
type: RelationshipXref
id: GO:0016212
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref237
type: RelationshipXref
id: 5637657
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637657

RelationshipXref234
type: RelationshipXref
id: GO:0097256
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref235
type: RelationshipXref
id: 5646410
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5646410

RelationshipXref232
type: RelationshipXref
id: GO:0036141
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref233
type: RelationshipXref
id: 5646408
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5646408

Evidence1717
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17371050
comment: Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).

Evidence1716
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12696021
xref: http://identifiers.org/pubmed/15342248
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

Evidence1719
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8824301
comment: Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).

Evidence1718
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12359132
xref: http://identifiers.org/pubmed/9889013
xref: http://identifiers.org/pubmed/14752098
comment: Mitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes the reaction of isobutyryl-CoA and FAD to form methacrylyl-CoA and FADH2 (Roe et al. 1999; Nguyen et al. 2002). Crystallographic studies have shown the active enzyme to be a tetramer of ACAD8 polypeptides whose aminoterminal 23 residues, a mitochondrial targeting sequence, have been removed (Bataille et al. 2004).

Evidence1713
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O to form beta-methylcrotonyl-CoA, ATP, and CO2. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptides are thought to have biotin moieties covalently bound to a lysine residue at position 681 in the polypeptide chain. Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences but the exact lengths of these sequences have not been determined.

Evidence1712
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16023992
xref: http://identifiers.org/pubmed/7356336
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylcrotonyl-CoA, ATP, and CO2 to form beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptide is thought to have a biotin moiety covalently bound to lysine residue 681. Localization of the complex to the mitochondrial inner membrane is inferred from studies of the bovine homologue (Hector et al. 1980). Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences (Stadler et al. 2005).

Evidence1715
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12696021
xref: http://identifiers.org/pubmed/15342248
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ to form alpha-methylacetoacetyl-CoA and NADH + H+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

Evidence1714
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10832746
xref: http://identifiers.org/pubmed/11013134
comment: Mitochondrial 2-methyl branched chain acyl-CoA dehydrogenase (ACADSB) catalyzes the reaction of alpha-methylbutyryl-CoA and FAD to form 'tiglyl-CoA and FADH2 (Andresen et al. 2000; Gibson et al. 2000). Unpublished crystallographic data (PDB 2JIF) indicate that the enzyme is a tetramer of ACADSB polypeptides whose aminoterminal 51 residues, a mitochondrial targeting sequence, have been removed.

Evidence1711
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6928646
xref: http://identifiers.org/pubmed/9214289
xref: http://identifiers.org/pubmed/3597357
comment: Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).

Evidence1710
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/11839747
xref: http://identifiers.org/pubmed/10745006
xref: http://identifiers.org/pubmed/2188967
xref: PublicationXref2810
xref: http://identifiers.org/pubmed/7918575
comment: The mitochondrial nranched-chain alpha-ketoacid dehydrogenase (BKCD) complex catalyzes the reactions of alpha-ketoisocaproate, alpha-keto beta-methylvalerate, or aalpha-ketoisovalerate with CoA and NAD+ to form isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA, respectively, and CO2 and NADH (Chuang and Shih 2001). While bovine and microbial BCKD complexes have been characterized most extensively (Reed and Hackert 1990), structural studies of individual components and subcomplexes of human BKCD have confirmed their structures and roles in the overall oxidative carboxylation process, and have related these features to the disruptive effects of mutations on branched-chain amino acid metabolism in vivo: E1a and E1b components - AEvarsson et al. 2000; E2 - Chang et al. 2002; E3- Brautigam et al. 2005. In addition, structural studies have confirmed the lipoylation of lysine residue 44 in E2 protein (Chang et al. 2002) and the loss of an aminoterminal mitochondrial transport sequence from mature E3 protein (Bruatigam et al. 2005). Loss of mitochondrial transport sequences from proteins E1a, E1b, and E2 has been domstrated by sequence analysis (Wynn et al. 1999).

RelationshipXref260
type: RelationshipXref
id: 5637409
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637409

RelationshipXref261
type: RelationshipXref
id: GO:0018146
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref262
type: RelationshipXref
id: GO:0004565
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref263
type: RelationshipXref
id: 5641916
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5641916

http://identifiers.org/pubmed/16341017
type: PublicationXref
id: 16341017
author: Tamai, K
author: Li, S
author: Habas, Raymond
author: Okamura, H
author: Doble, B
author: Zeng, X
author: Woodgett, J
author: Huang, H
author: He, Xi
db: Pubmed
title: A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
source: Nature 438:873-7
year: 2005

RelationshipXref264
type: RelationshipXref
id: GO:0042340
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref265
type: RelationshipXref
id: GO:0042339
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref266
type: RelationshipXref
id: GO:0046525
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref267
type: RelationshipXref
id: 5643456
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643456

RelationshipXref268
type: RelationshipXref
id: GO:0047220
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref269
type: RelationshipXref
id: 5643450
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643450

http://identifiers.org/pubmed/183598
type: PublicationXref
id: 183598
author: Clark, P
author: Edwards, YH
author: Harris, H
db: Pubmed
title: Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals.
source: Ann Hum Genet 40:67-77
year: 1976

Evidence1729
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6434529
xref: http://identifiers.org/pubmed/10775527
comment: The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of lysine, alpha-ketoglutarate, and NADPH + H+ to form saccharopine, NADP+, and H2O (Markovitz et al. 1984; Sacksteder et al. 2001).

Evidence1728
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5057083
comment: The major pathway of histidine catabolism, annotated here, proceeds in four steps to yield glutamate and, in the process, convert one molecule of tetrahydrofolate to 5-formiminotetrahydrofolate (Morris et al. 1972). Histidine can also be decarboxylated to form histamine.

Evidence1727
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1425659
comment: Decarboxylation of L-Histidine happens analogously to other decarboxylations of amino acids. It uses the cofactor pyridoxal phosphate and is catalyzed by histidine decarboxylase (Mamune-Sato et al, 1992).

Evidence1726
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15221005
comment: Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).

Evidence1725
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15221005
xref: http://identifiers.org/pubmed/19304569
comment: Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).

Evidence1724
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15806399
comment: Cytosolic histidine ammonia lyase (HAL) catalyzes the reaction of histidine to form urocanate and NH4+ (Kawai et al. 2005).

Evidence1723
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2831
xref: PublicationXref2810
comment: The branched-chain amino acids, leucine, isoleucine, and valine, are all essential amino acids (i.e., ones required in the diet). They are major constituents of muscle protein. The breakdown of these amino acids starts with two common steps catalyzed by enzymes that act on all three amino acids: reversible transamination by branched-chain amino acid aminotransferase, and irreversible oxidative decarboxylation by the branched-chain ketoacid dehydrogenase complex. Isovaleryl-CoA is produced from leucine by these two reactions, alpha-methylbutyryl-CoA from isoleucine, and isobutyryl-CoA from valine. These acyl-CoA's undergo dehydrogenation, catalyzed by three different but related enzymes, and the breakdown pathways then diverge. Leucine is ultimately converted to acetyl-CoA and acetoacetate; isoleucine to acetyl-CoA and succinyl-CoA; and valine to succinyl-CoA. Under fasting conditions, substantial amounts of all three amino acids are generated by protein breakdown. In muscle, the final products of leucine, isoleucine, and valine catabolism can be fully oxidized via the citric acid cycle; in liver they can be directed toward the synthesis of ketone bodies (acetoacetate and acetyl-CoA) and glucose (succinyl-CoA) (Chuang & Shih 2001, Sweetman & Williams 2001).

Evidence1722
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10947204
xref: http://identifiers.org/pubmed/1527093
comment: Mitochondrial methylmalonate semialdehyde dehydrogenase (ALDH6A1) catalyzes the reaction of methylmalonate semialdehyde, NAD+, and CoA to form propionyl-CoA, CO2, and NADH + H+. A human ALDH6A1 gene has been cloned. Its sequence is closely homologous to that of the better-characterized rat enzyme (Kedishvili et al. 1992) and a missense mutation in a normally well-conserved codon has been found in the allele of the gene from a patient with a defect in methylmalonic semialdehyde dehydrogenase activity (Chambliss et al. 2000).

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, Henri-Gery
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

Evidence1721
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of methylmalonyl semialdehyde and NADH + H+ to form beta-hydroxyisobutyrate and NAD+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

Evidence1720
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of beta-hydroxyisobutyrate and NAD+ to form methylmalonyl semialdehyde and NADH + H+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

RelationshipXref252
type: RelationshipXref
id: GO:0004781
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref253
type: RelationshipXref
id: 5625652
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625652

RelationshipXref250
type: RelationshipXref
id: GO:0015116
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref251
type: RelationshipXref
id: 5634065
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5634065

RelationshipXref256
type: RelationshipXref
id: GO:0046964
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref257
type: RelationshipXref
id: 5637374
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637374

RelationshipXref254
type: RelationshipXref
id: GO:0004020
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref255
type: RelationshipXref
id: 5625640
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625640

RelationshipXref258
type: RelationshipXref
id: GO:0050428
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref259
type: RelationshipXref
id: GO:0005338
db: GENE ONTOLOGY
relationship type: MI:0355

phospho-p-S1108,S1148,S1192-EIF4G1
type: Protein
entity reference: UniProt:B5BM24
data source: Provenance1
xref: UnificationXref22754
feature: FragmentFeature5749
feature: ModificationFeature1223
feature: ModificationFeature1221
feature: ModificationFeature1222
cellular location: GO_0005829
comment: Reactome DB_ID: 5624950

Homologues of CAB39
type: Protein
data source: Provenance1
member physical entity: CAB39_HUMAN
xref: UnificationXref22770
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628248

phospho-p-S1108,S1148,S1192-EIF4G1
type: Protein
entity reference: Q21531
data source: Provenance1
xref: UnificationXref22752
feature: ModificationFeature1215
feature: ModificationFeature1216
feature: ModificationFeature1217
feature: FragmentFeature5747
cellular location: GO_0005829
comment: Reactome DB_ID: 5624942

phospho-p-S1108,S1148,S1192-EIF4G1
type: Protein
entity reference: UniProt:B5BM23
data source: Provenance1
xref: UnificationXref22753
feature: ModificationFeature1218
feature: ModificationFeature1219
feature: FragmentFeature5748
feature: ModificationFeature1220
cellular location: GO_0005829
comment: Reactome DB_ID: 5624946

phospho-p-S1108,S1148,S1192-EIF4G1
type: Protein
entity reference: UniProt:B5BM25
data source: Provenance1
xref: UnificationXref22750
feature: ModificationFeature1209
feature: FragmentFeature5745
feature: ModificationFeature1210
feature: ModificationFeature1211
cellular location: GO_0005829
comment: Reactome DB_ID: 5624934

RelationshipXref289
type: RelationshipXref
id: GO:0006027
db: GENE ONTOLOGY
relationship type: MI:0359

phospho-p-S1108,S1148,S1192-EIF4G1
type: Protein
entity reference: Q7JMF0
data source: Provenance1
xref: UnificationXref22751
feature: ModificationFeature1214
feature: FragmentFeature5746
feature: ModificationFeature1212
feature: ModificationFeature1213
cellular location: GO_0005829
comment: Reactome DB_ID: 5624938

RelationshipXref288
type: RelationshipXref
id: 5642646
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5642646

RelationshipXref287
type: RelationshipXref
id: GO:0004561
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref286
type: RelationshipXref
id: GO:0006024
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref285
type: RelationshipXref
id: 5645807
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645807

RelationshipXref284
type: RelationshipXref
id: GO:0017095
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref283
type: RelationshipXref
id: 5645799
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645799

RelationshipXref282
type: RelationshipXref
id: 5645823
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645823

RelationshipXref281
type: RelationshipXref
id: GO:0008467
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref280
type: RelationshipXref
id: 5645813
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645813

Homologues of CAB39L
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22774
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628252

CAB39_HUMAN
type: Protein
entity reference: O18211
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O18211
name: MO25-alpha
name: Calcium-binding protein 39
xref: UnificationXref22769
feature: FragmentFeature5752
cellular location: GO_0005829
comment: Reactome DB_ID: 5628247
display name: CAB39

CAB39_HUMAN
type: Protein
entity reference: Q7Z2A5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7Z2A5
name: MO25-alpha
name: Calcium-binding protein 39
xref: UnificationXref22767
feature: FragmentFeature5751
cellular location: GO_0005829
comment: Reactome DB_ID: 5628243
display name: CAB39

CAB39_HUMAN
type: Protein
entity reference: Q21643
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q21643
name: MO25-alpha
name: Calcium-binding protein 39
xref: UnificationXref22765
feature: FragmentFeature5750
cellular location: GO_0005829
comment: Reactome DB_ID: 5628241
display name: CAB39

Q9GN62
type: Protein
entity reference: Q9GN62
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: STK11(1-433)
xref: UnificationXref22776
feature: FragmentFeature5756
cellular location: GO_0005829
comment: Reactome DB_ID: 5628237
display name: LKB1

STRAD
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22780
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628259

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5ECN5
data source: Provenance1
name: STRAD_HUMAN
name: STRAD-alpha
name: G5ECN5
name: STE20-related adapter protein
xref: UnificationXref22778
feature: FragmentFeature5757
cellular location: GO_0005829
comment: Reactome DB_ID: 5628257
display name: STRADA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5ECN5
data source: Provenance1
name: Pseudokinase ALS2CR2
name: G5ECN5
name: STRAD-beta
name: ALS2CR2
name: AL2S2_HUMAN
xref: UnificationXref22779
feature: FragmentFeature5758
cellular location: GO_0005829
comment: Reactome DB_ID: 5628258
display name: STRADB

RelationshipXref277
type: RelationshipXref
id: GO:0050379
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref276
type: RelationshipXref
id: 5645337
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645337

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q21643
data source: Provenance1
name: Calcium-binding protein 39-like
name: Q21643
name: MO25-beta
name: CB39L_HUMAN
xref: UnificationXref22771
feature: FragmentFeature5753
cellular location: GO_0005829
comment: Reactome DB_ID: 5628249
display name: CAB39L

RelationshipXref279
type: RelationshipXref
id: GO:0004394
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7Z2A5
data source: Provenance1
name: Q7Z2A5
name: Calcium-binding protein 39-like
name: MO25-beta
name: CB39L_HUMAN
xref: UnificationXref22772
feature: FragmentFeature5754
cellular location: GO_0005829
comment: Reactome DB_ID: 5628250
display name: CAB39L

RelationshipXref278
type: RelationshipXref
id: 5645398
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645398

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O18211
data source: Provenance1
name: Calcium-binding protein 39-like
name: O18211
name: MO25-beta
name: CB39L_HUMAN
xref: UnificationXref22773
feature: FragmentFeature5755
cellular location: GO_0005829
comment: Reactome DB_ID: 5628251
display name: CAB39L

RelationshipXref273
type: RelationshipXref
id: GO:0050119
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref272
type: RelationshipXref
id: GO:0030203
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref275
type: RelationshipXref
id: GO:0015016
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref274
type: RelationshipXref
id: 5645353
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645353

RelationshipXref271
type: RelationshipXref
id: 5643428
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643428

RelationshipXref270
type: RelationshipXref
id: GO:0015018
db: GENE ONTOLOGY
relationship type: MI:0355

P45894
type: Protein
entity reference: P45894
data source: Provenance1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1
name: Note: the coordinates are copied over from Homo sapiens.
name: AAPK1_HUMAN
name: AMPK alpha1
xref: UnificationXref22784
feature: FragmentFeature5759
cellular location: GO_0005829
comment: Reactome DB_ID: 5628208
display name: PRKAA1

Homologues of PRKAA1
type: Protein
data source: Provenance1
member physical entity: P45894
member physical entity: 5'-AMP-activated protein kinase catalytic subunit alpha-1
xref: UnificationXref22786
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628210

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: Protein
entity reference: Q95ZQ4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q95ZQ4
name: AAPK1_HUMAN
name: AMPK alpha1
xref: UnificationXref22785
feature: FragmentFeature5760
cellular location: GO_0005829
comment: Reactome DB_ID: 5628209
display name: PRKAA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q95ZQ4
data source: Provenance1
name: AMPK alpha2 (inactive)
name: Q95ZQ4
xref: UnificationXref22788
feature: FragmentFeature5762
cellular location: GO_0005829
comment: Reactome DB_ID: 5628212
display name: PRKAA2

AMPK gamma
type: Protein
data source: Provenance1
member physical entity: Protein2680
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22793
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628225

Homologues of PRKAA2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P45894
xref: UnificationXref22789
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628213

P45894
type: Protein
entity reference: P45894
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: AMPK alpha2 (inactive)
xref: UnificationXref22787
feature: FragmentFeature5761
cellular location: GO_0005829
comment: Reactome DB_ID: 5628211
display name: PRKAA2

Homologues of PRKAB1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22796
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628217

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9NAH7
data source: Provenance1
name: AAKB1_HUMAN
name: 5'-AMP-activated protein kinase subunit beta-1
name: Q9NAH7
name: AMPK beta1
xref: UnificationXref22794
feature: FragmentFeature5765
cellular location: GO_0005829
comment: Reactome DB_ID: 5628215
display name: PRKAB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9BHL6
data source: Provenance1
name: Q9BHL6
name: 5'-AMP-activated protein kinase subunit gamma-1
name: AMPK gamma1
name: AAKG1_HUMAN
xref: UnificationXref22791
feature: FragmentFeature5763
cellular location: GO_0005829
comment: Reactome DB_ID: 5628222
display name: PRKAG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9BHL6
data source: Provenance1
name: Q9BHL6
name: AAKG3_HUMAN
name: AMPK gamma3
name: 5'-AMP-activated protein kinase subunit gamma-3
xref: UnificationXref22792
feature: FragmentFeature5764
cellular location: GO_0005829
comment: Reactome DB_ID: 5628224
display name: PRKAG3

Homologues of p-T174-PRKAA1
type: Protein
data source: Provenance1
member physical entity: phospho-p-T174-PRKAA1
xref: UnificationXref22801
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5628234

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XUY2
data source: Provenance1
name: Q9XUY2
name: AAKB1_HUMAN
name: 5'-AMP-activated protein kinase subunit beta-1
name: AMPK beta1
xref: UnificationXref22795
feature: FragmentFeature5766
cellular location: GO_0005829
comment: Reactome DB_ID: 5628216
display name: PRKAB1

RelationshipXref299
type: RelationshipXref
id: GO:0030204
db: GENE ONTOLOGY
relationship type: MI:0359

phospho-p-T174-PRKAA1
type: Protein
entity reference: Q95ZQ4
data source: Provenance1
xref: UnificationXref22800
feature: ModificationFeature1225
feature: FragmentFeature5768
cellular location: GO_0005829
comment: Reactome DB_ID: 5628233

RelationshipXref298
type: RelationshipXref
id: GO:0030207
db: GENE ONTOLOGY
relationship type: MI:0359

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P49596
data source: Provenance1
name: P49596
xref: UnificationXref22808
feature: FragmentFeature5769
cellular location: GO_0005829
comment: Reactome DB_ID: 5631947
display name: PPM1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EED4
data source: Provenance1
name: G5EED4
name: TRB-3
xref: UnificationXref22827
feature: FragmentFeature5770
cellular location: GO_0005829
comment: Reactome DB_ID: 5623424
display name: TRIB3

Homologues of p-4S-SOS1
type: Protein
data source: Provenance1
member physical entity: phospho-p-4S-SOS1
xref: UnificationXref22845
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5623485

phospho-p-4S-SOS1
type: Protein
entity reference: Q9N5D3
data source: Provenance1
xref: UnificationXref22843
feature: ModificationFeature1227
feature: ModificationFeature1228
feature: ModificationFeature1226
feature: ModificationFeature1229
feature: FragmentFeature5771
cellular location: GO_0005829
comment: Reactome DB_ID: 5623479

phospho-p-4S-SOS1
type: Protein
entity reference: Q9NBD3
data source: Provenance1
xref: UnificationXref22844
feature: ModificationFeature1232
feature: ModificationFeature1233
feature: FragmentFeature5772
feature: ModificationFeature1230
feature: ModificationFeature1231
cellular location: GO_0005829
comment: Reactome DB_ID: 5623484

Mitogen-activated protein kinase
type: Protein
data source: Provenance1
member physical entity: Protein933
xref: UnificationXref22847
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5623490

insulin receptor alpha subunit
type: Protein
entity reference: Q968Y9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q968Y9
name: INSR(28-758)
xref: UnificationXref22857
feature: FragmentFeature5773
cellular location: GO_0010008
comment: Reactome DB_ID: 5622333
display name: INSR

RelationshipXref291
type: RelationshipXref
id: 5643558
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643558

RelationshipXref290
type: RelationshipXref
id: GO:0050510
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref293
type: RelationshipXref
id: 5643554
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5643554

RelationshipXref292
type: RelationshipXref
id: GO:0047238
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref295
type: RelationshipXref
id: GO:0030208
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref294
type: RelationshipXref
id: GO:0030206
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref297
type: RelationshipXref
id: 5641980
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5641980

RelationshipXref296
type: RelationshipXref
id: GO:0003943
db: GENE ONTOLOGY
relationship type: MI:0355

phospho-p-T174-PRKAA1
type: Protein
entity reference: P45894
data source: Provenance1
xref: UnificationXref22799
feature: FragmentFeature5767
feature: ModificationFeature1224
cellular location: GO_0005829
comment: Reactome DB_ID: 5628231

insulin receptor beta subunit
type: Protein
entity reference: Q968Y9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: INSR(763-1382)
xref: UnificationXref22858
feature: FragmentFeature5774
cellular location: GO_0010008
comment: Reactome DB_ID: 5622342
display name: Q968Y9

SequenceSite3089
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10327068
type: PublicationXref
id: 10327068
author: Ueno, H
author: Takahashi, T
author: Shibuya, M
db: Pubmed
title: VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
source: Oncogene 18:2221-30
year: 1999

SequenceSite3087
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3088
type: SequenceSite
position status: EQUAL
sequence position: 316

SequenceSite3085
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3086
type: SequenceSite
position status: EQUAL
sequence position: 579

SequenceSite3083
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of PMS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22641
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5652345

SequenceSite3084
type: SequenceSite
position status: EQUAL
sequence position: 547

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XU10
data source: Provenance1
name: MLH1_HUMAN
name: Q9XU10
name: DNA mismatch repair protein Mlh1
xref: UnificationXref22636
feature: FragmentFeature5714
cellular location: GO_0005654
comment: Reactome DB_ID: 5652338
display name: MLH1

SequenceSite3081
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3082
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite3080
type: SequenceSite
position status: EQUAL
sequence position: 134

phospho-p-Y-SHC1
type: Protein
entity reference: H2KZG2
data source: Provenance1
xref: UnificationXref22682
feature: ModificationFeature1192
feature: FragmentFeature5720
cellular location: GO_0005829
comment: Reactome DB_ID: 5622367

phospho-p-Y-SHC1
type: Protein
entity reference: Q9TYT3
data source: Provenance1
xref: UnificationXref22683
feature: ModificationFeature1193
feature: FragmentFeature5721
cellular location: GO_0005829
comment: Reactome DB_ID: 5622370

phospho-p-Y-SHC1
type: Protein
entity reference: H2KZG1
data source: Provenance1
xref: UnificationXref22680
feature: FragmentFeature5718
feature: ModificationFeature1190
cellular location: GO_0005829
comment: Reactome DB_ID: 5622361

phospho-p-Y-SHC1
type: Protein
entity reference: H2KZG0
data source: Provenance1
xref: UnificationXref22681
feature: ModificationFeature1191
feature: FragmentFeature5719
cellular location: GO_0005829
comment: Reactome DB_ID: 5622364

Exonuclease 1
type: Protein
entity reference: O62245
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EXO1_HUMAN
name: O62245
xref: UnificationXref22652
feature: FragmentFeature5717
cellular location: GO_0005654
comment: Reactome DB_ID: 5652373
display name: EXO1

Homologues of p-Y-SHC1
type: Protein
data source: Provenance1
member physical entity: phospho-p-Y-SHC1
xref: UnificationXref22684
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5622371

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XXM5
data source: Provenance1
name: PMS2_HUMAN
name: Q9XXM5
name: Mismatch repair endonuclease PMS2 ecNumber3.1.-.-/ecNumber
xref: UnificationXref22638
feature: FragmentFeature5715
cellular location: GO_0005654
comment: Reactome DB_ID: 5652342
display name: PMS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EFG5
data source: Provenance1
name: PMS2_HUMAN
name: G5EFG5
name: Mismatch repair endonuclease PMS2 ecNumber3.1.-.-/ecNumber
xref: UnificationXref22640
feature: FragmentFeature5716
cellular location: GO_0005654
comment: Reactome DB_ID: 5652344
display name: PMS2

SequenceSite3078
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite3079
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3074
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite3075
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3076
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite3077
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3070
type: SequenceSite
position status: EQUAL
sequence position: 1458

Homologues of p-Y-SHC2
type: Protein
data source: Provenance1
member physical entity: phospho-p-Y-SHC2
xref: UnificationXref22689
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5622376

SequenceSite3071
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite3072
type: SequenceSite
position status: EQUAL
sequence position: 1458

phospho-p-Y-SHC2
type: Protein
entity reference: H2KZG0
data source: Provenance1
xref: UnificationXref22686
feature: ModificationFeature1191
feature: FragmentFeature5723
cellular location: GO_0005829
comment: Reactome DB_ID: 5622373

SequenceSite3073
type: SequenceSite
position status: EQUAL
sequence position: 2

phospho-p-Y-SHC2
type: Protein
entity reference: H2KZG1
data source: Provenance1
xref: UnificationXref22685
feature: ModificationFeature1190
feature: FragmentFeature5722
cellular location: GO_0005829
comment: Reactome DB_ID: 5622372

http://identifiers.org/pubmed/16399380
type: PublicationXref
id: 16399380
author: Schmuck, E
author: Masoumi, A
author: Coggan, M
author: Tetlow, N
author: Board, PG
author: Whitbread, AK
db: Pubmed
title: Characterization of the omega class of glutathione transferases
source: Methods Enzymol 401:78-99
year: 2005

SequenceSite19400
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19401
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19403
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-Y-SHC3
type: Protein
entity reference: H2KZG0
data source: Provenance1
xref: UnificationXref22691
feature: ModificationFeature1191
feature: FragmentFeature5727
cellular location: GO_0005829
comment: Reactome DB_ID: 5622378

SequenceSite19402
type: SequenceSite
position status: EQUAL
sequence position: 1497

phospho-p-Y-SHC3
type: Protein
entity reference: H2KZG2
data source: Provenance1
xref: UnificationXref22692
feature: ModificationFeature1192
feature: FragmentFeature5728
cellular location: GO_0005829
comment: Reactome DB_ID: 5622379

SequenceSite19405
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-Y-SHC3
type: Protein
entity reference: Q9TYT3
data source: Provenance1
xref: UnificationXref22693
feature: FragmentFeature5729
feature: ModificationFeature1193
cellular location: GO_0005829
comment: Reactome DB_ID: 5622380

SequenceSite19404
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19407
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-Y-SHC2
type: Protein
entity reference: H2KZG2
data source: Provenance1
xref: UnificationXref22687
feature: ModificationFeature1192
feature: FragmentFeature5724
cellular location: GO_0005829
comment: Reactome DB_ID: 5622374

SequenceSite19406
type: SequenceSite
position status: EQUAL
sequence position: 1497

phospho-p-Y-SHC2
type: Protein
entity reference: Q9TYT3
data source: Provenance1
xref: UnificationXref22688
feature: ModificationFeature1193
feature: FragmentFeature5725
cellular location: GO_0005829
comment: Reactome DB_ID: 5622375

SequenceSite19409
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of p-Y-SHC3
type: Protein
data source: Provenance1
member physical entity: phospho-p-Y-SHC3
xref: UnificationXref22694
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5622381

SequenceSite19408
type: SequenceSite
position status: EQUAL
sequence position: 1497

phospho-p-Y-SHC3
type: Protein
entity reference: H2KZG1
data source: Provenance1
xref: UnificationXref22690
feature: ModificationFeature1190
feature: FragmentFeature5726
cellular location: GO_0005829
comment: Reactome DB_ID: 5622377

Evidence1794
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1722671
comment: The first step in the biogenesis of thyroid hormones is the oxidation of iodide (I-) by H2O2/peroxidase after being taken up by the thyroid gland. This event is known as organification.

Evidence1795
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Tyrosines can be iodinated in thyroglobulin to produce precursors for thyroid hormone synthesis.

Evidence1792
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1684650
xref: http://identifiers.org/pubmed/363400
xref: http://identifiers.org/pubmed/10691773
comment: The catecholamine neurotransmitters dopamine, noradrenaline and adrenaline are found in nervous tissue of animals. They are synthesized in catecholaminergic neurons by four enzymes from tyrosine to adrenaline: tyrosine hydroxylase (TH); aromatic L-amino acid decarboxylase (AADC); dopamine beta-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT).

Evidence1793
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8806637
comment: Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- symporter (sodium/iodide). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration 30-40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I-.

Evidence1790
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1857555
xref: http://identifiers.org/pubmed/3443096
xref: http://identifiers.org/pubmed/7961964
comment: Dopamine beta-hydroxylase (DBH; dopamine beta-monooxygenase) is a copper-containing glycoprotein consisting of four identical subunits and catalyzes the oxidation of dopamine to norepinephrine. It requires ascorbic acid as an electron donor. DBH is localized in the norepinephrinergic and epinephrinergic neurons in the central nervous system. The enzyme exists in the secretory vesicles as both soluble and membrane-bound forms. The soluble form is secreted with catecholamines by exocytosis whereas the membrane-bound form is recycled into the vesicles.

Evidence1791
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3372503
comment: Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in catecholamine biosynthesis. It performs transmethylation of noradrenaline to adrenaline using S-adenosyl L-methionine (SAM) as the methyl donor.

SequenceSite19411
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19412
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19410
type: SequenceSite
position status: EQUAL
sequence position: 1497

Homologues of AKT2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22719
cellular location: GO_0005829
comment: Reactome DB_ID: 5623433
comment: Converted from EntitySet in Reactome

phospho-p-S318-PDE3B
type: Protein
entity reference: Q8I0P7
data source: Provenance1
xref: UnificationXref22716
feature: ModificationFeature1194
feature: FragmentFeature5731
cellular location: GO_0005829
comment: Reactome DB_ID: 5624634

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I0P7
data source: Provenance1
name: Phosphodiesterase 3B
name: Q8I0P7
xref: UnificationXref22715
feature: FragmentFeature5730
cellular location: GO_0005829
comment: Reactome DB_ID: 5624632
display name: PDE3B

PI3K-regulatory subunit
type: Protein
data source: Provenance1
member physical entity: Protein948
member physical entity: Protein3036
xref: UnificationXref22709
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5623291

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9NAH6
data source: Provenance1
name: RPS6KB1
name: Q9NAH6
xref: UnificationXref22727
feature: FragmentFeature5734
cellular location: GO_0005829
comment: Reactome DB_ID: 5624870
display name: S6K1

SequenceSite19419
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-S371,T389-RPS6KB1
type: Protein
entity reference: Q9NAH6
data source: Provenance1
xref: UnificationXref22728
feature: FragmentFeature5735
feature: ModificationFeature1195
feature: ModificationFeature1196
cellular location: GO_0005829
comment: Reactome DB_ID: 5624873

SequenceSite19418
type: SequenceSite
position status: EQUAL
sequence position: 1497

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XTG7
data source: Provenance1
name: Protein kinase Akt-2
name: RAC-PK-beta
name: Q9XTG7
name: PKB beta
name: Protein kinase B, beta
name: RAC-beta serine/threonine protein kinase
xref: UnificationXref22717
feature: FragmentFeature5732
cellular location: GO_0005829
comment: Reactome DB_ID: 5623428
display name: AKT2

SequenceSite19417
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q17941
data source: Provenance1
name: Q17941
name: Protein kinase Akt-2
name: RAC-PK-beta
name: PKB beta
name: Protein kinase B, beta
name: RAC-beta serine/threonine protein kinase
xref: UnificationXref22718
feature: FragmentFeature5733
cellular location: GO_0005829
comment: Reactome DB_ID: 5623432
display name: AKT2

SequenceSite19416
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19415
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19414
type: SequenceSite
position status: EQUAL
sequence position: 1497

Homologues of RPTOR
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22733
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5624901

SequenceSite19413
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EEV7
data source: Provenance1
name: G5EEV7
name: Regulatory-associated protein of mTOR
name: RPTOR_HUMAN
xref: UnificationXref22730
feature: FragmentFeature5736
cellular location: GO_0005829
comment: Reactome DB_ID: 5624896
display name: RPTOR

Evidence1799
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Mono- and di-iodinated tyrosine can combine to form tri-iodothyronine (T3). The hormone thyrotropin can stimulate the production of T3 and T4.

Evidence1798
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16910871
comment: The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).

Evidence1797
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Tyrosines can be iodinated in thyroglobulin to produce precursors for thyroid hormone synthesis.

Evidence1796
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16910871
comment: The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).

SequenceSite3096
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite3097
type: SequenceSite
position status: EQUAL
sequence position: 112

SequenceSite3098
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3099
type: SequenceSite
position status: EQUAL
sequence position: 533

SequenceSite19420
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19421
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19422
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3090
type: SequenceSite
position status: EQUAL
sequence position: 316

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EF88
data source: Provenance1
name: Regulatory-associated protein of mTOR
name: G5EF88
name: RPTOR_HUMAN
xref: UnificationXref22731
feature: FragmentFeature5737
cellular location: GO_0005829
comment: Reactome DB_ID: 5624898
display name: RPTOR

SequenceSite19423
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3091
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3092
type: SequenceSite
position status: EQUAL
sequence position: 316

Homologues of p-S722,S792-RPTOR
type: Protein
data source: Provenance1
member physical entity: phospho-p-S722,S792-RPTOR
xref: UnificationXref22741
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5624913

SequenceSite3093
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q68TI8
data source: Provenance1
name: Q68TI8
name: Regulatory-associated protein of mTOR
name: RPTOR_HUMAN
xref: UnificationXref22732
feature: FragmentFeature5738
cellular location: GO_0005829
comment: Reactome DB_ID: 5624900
display name: RPTOR

SequenceSite3094
type: SequenceSite
position status: EQUAL
sequence position: 323

phospho-p-S722,S792-RPTOR
type: Protein
entity reference: G5EF88
data source: Provenance1
xref: UnificationXref22739
feature: FragmentFeature5740
feature: ModificationFeature1200
feature: ModificationFeature1199
cellular location: GO_0005829
comment: Reactome DB_ID: 5624909

SequenceSite3095
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-S722,S792-RPTOR
type: Protein
entity reference: G5EEV7
data source: Provenance1
xref: UnificationXref22738
feature: FragmentFeature5739
feature: ModificationFeature1197
feature: ModificationFeature1198
cellular location: GO_0005829
comment: Reactome DB_ID: 5624906

SequenceSite19429
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-S722,S792-RPTOR
type: Protein
entity reference: Q68TI8
data source: Provenance1
xref: UnificationXref22740
feature: ModificationFeature1202
feature: FragmentFeature5741
feature: ModificationFeature1201
cellular location: GO_0005829
comment: Reactome DB_ID: 5624912

SequenceSite19428
type: SequenceSite
position status: EQUAL
sequence position: 1497

phospho-p-5S-RPS6
type: Protein
entity reference: Q9NEN6
data source: Provenance1
xref: UnificationXref22742
feature: ModificationFeature1207
feature: ModificationFeature1206
feature: ModificationFeature1205
feature: ModificationFeature1204
feature: FragmentFeature5742
feature: ModificationFeature1203
cellular location: GO_0005829
comment: Reactome DB_ID: 5624921

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O01991
data source: Provenance1
name: eEF2K
name: O01991
xref: UnificationXref22746
feature: FragmentFeature5743
cellular location: GO_0005829
comment: Reactome DB_ID: 5624927
display name: EEF2K

phospho-p-S366-EEF2K
type: Protein
entity reference: O01991
data source: Provenance1
xref: UnificationXref22747
feature: ModificationFeature1208
feature: FragmentFeature5744
cellular location: GO_0005829
comment: Reactome DB_ID: 5624929

SequenceSite19425
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of p-S1108,S1148,S1192-EIF4G1
type: Protein
data source: Provenance1
member physical entity: phospho-p-S1108,S1148,S1192-EIF4G1
xref: UnificationXref22755
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5624951

SequenceSite19424
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19427
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19426
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3029
type: SequenceSite
position status: EQUAL
sequence position: 533

SequenceSite3027
type: SequenceSite
position status: EQUAL
sequence position: 91

SequenceSite3028
type: SequenceSite
position status: EQUAL
sequence position: 37

UnificationXref22701
type: UnificationXref
id: 5652650
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652650

UnificationXref22702
type: UnificationXref
id: REACT_248145
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248145.1

UnificationXref22700
type: UnificationXref
id: REACT_254030
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254030.1

SequenceSite19448
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19449
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19446
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19447
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19445
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19444
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22709
type: UnificationXref
id: 5623291
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623291

SequenceSite19443
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22708
type: UnificationXref
id: 5623417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623417

SequenceSite19442
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22707
type: UnificationXref
id: REACT_5133
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5133.3

SequenceSite19441
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22706
type: UnificationXref
id: 38117
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=38117

SequenceSite19440
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22705
type: UnificationXref
id: CHEBI:16618
db: ChEBI

UnificationXref11661
type: UnificationXref
id: 111399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111399

UnificationXref22704
type: UnificationXref
id: REACT_256461
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256461.1

UnificationXref11660
type: UnificationXref
id: CHEBI:18319
db: ChEBI

UnificationXref22703
type: UnificationXref
id: 5652651
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652651

UnificationXref11663
type: UnificationXref
id: 5621880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621880

SequenceSite3033
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/3722183
type: PublicationXref
id: 3722183
author: Fessler, JH
author: Doege, KJ
db: Pubmed
title: Folding of carboxyl domain and assembly of procollagen I
source: J Biol Chem 261:8924-35
year: 1986

UnificationXref11662
type: UnificationXref
id: REACT_3661
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3661.2

SequenceSite3032
type: SequenceSite
position status: EQUAL
sequence position: 533

UnificationXref11665
type: UnificationXref
id: CHEBI:18406
db: ChEBI

SequenceSite3031
type: SequenceSite
position status: EQUAL
sequence position: 37

UnificationXref11664
type: UnificationXref
id: REACT_261835
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261835.1

SequenceSite3030
type: SequenceSite
position status: EQUAL
sequence position: 91

http://identifiers.org/pubmed/10567430
type: PublicationXref
id: 10567430
author: Wedegaertner, PB
author: Parent, JL
author: Kozasa, T
author: Gilman, AG
author: Carman, CV
author: Sternweis, PM
author: Benovic, JL
author: Pronin, AN
author: Day, PW
db: Pubmed
title: Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2
source: J Biol Chem 274:34483-92
year: 1999

UnificationXref11667
type: UnificationXref
id: REACT_2302
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2302.2

SequenceSite3037
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11666
type: UnificationXref
id: 111409
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111409

SequenceSite3036
type: SequenceSite
position status: EQUAL
sequence position: 135

UnificationXref11669
type: UnificationXref
id: 29586
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29586

SequenceSite3035
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11668
type: UnificationXref
id: CHEBI:37154
db: ChEBI

SequenceSite3034
type: SequenceSite
position status: EQUAL
sequence position: 135

SequenceSite3038
type: SequenceSite
position status: EQUAL
sequence position: 135

SequenceSite3039
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11659
type: UnificationXref
id: REACT_254372
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254372.1

SequenceSite19439
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22710
type: UnificationXref
id: 5623296
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623296

UnificationXref22711
type: UnificationXref
id: 5623418
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623418

UnificationXref22712
type: UnificationXref
id: 5623420
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623420

UnificationXref22713
type: UnificationXref
id: REACT_231458
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231458.1

SequenceSite19435
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19436
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19437
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19438
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19432
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22719
type: UnificationXref
id: 5623433
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623433

SequenceSite19431
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22718
type: UnificationXref
id: 5623432
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623432

SequenceSite19434
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19433
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11650
type: UnificationXref
id: 5621888
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621888

UnificationXref22715
type: UnificationXref
id: 5624632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624632

UnificationXref22714
type: UnificationXref
id: Q8I0P7
db: UniProt

SequenceSite19430
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3040
type: SequenceSite
position status: EQUAL
sequence position: 135

UnificationXref22717
type: UnificationXref
id: 5623428
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623428

UnificationXref22716
type: UnificationXref
id: 5624634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624634

UnificationXref11654
type: UnificationXref
id: REACT_3113
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3113.2

SequenceSite3042
type: SequenceSite
position status: EQUAL
sequence position: 135

UnificationXref11653
type: UnificationXref
id: 111395
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111395

SequenceSite3041
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11652
type: UnificationXref
id: CHEBI:28413
db: ChEBI

SequenceSite3044
type: SequenceSite
position status: EQUAL
sequence position: 393

UnificationXref11651
type: UnificationXref
id: REACT_233098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233098.1

SequenceSite3043
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11658
type: UnificationXref
id: 5621882
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621882

SequenceSite3046
type: SequenceSite
position status: EQUAL
sequence position: 393

UnificationXref11657
type: UnificationXref
id: 5621878
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621878

SequenceSite3045
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11656
type: UnificationXref
id: 5621877
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621877

SequenceSite3048
type: SequenceSite
position status: EQUAL
sequence position: 393

UnificationXref11655
type: UnificationXref
id: Q10457
db: UniProt

SequenceSite3047
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3049
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22720
type: UnificationXref
id: 5623435
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623435

SequenceSite19468
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19469
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22723
type: UnificationXref
id: 5624638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624638

UnificationXref22724
type: UnificationXref
id: REACT_234901
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234901.1

UnificationXref22721
type: UnificationXref
id: 5624636
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624636

UnificationXref22722
type: UnificationXref
id: REACT_240955
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240955.1

SequenceSite19463
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11681
type: UnificationXref
id: Q7JNV5
db: UniProt

SequenceSite3051
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref22728
type: UnificationXref
id: 5624873
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624873

SequenceSite19462
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11680
type: UnificationXref
id: 5621856
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621856

SequenceSite3050
type: SequenceSite
position status: EQUAL
sequence position: 393

UnificationXref22727
type: UnificationXref
id: 5624870
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624870

SequenceSite19461
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11683
type: UnificationXref
id: Q95QQ5
db: UniProt

UnificationXref22726
type: UnificationXref
id: REACT_253534
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253534.1

SequenceSite19460
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11682
type: UnificationXref
id: 5621858
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621858

UnificationXref22725
type: UnificationXref
id: 5652863
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652863

SequenceSite19467
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19466
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19465
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19464
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22729
type: UnificationXref
id: 5624892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624892

UnificationXref11689
type: UnificationXref
id: 5621864
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621864

SequenceSite3059
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11688
type: UnificationXref
id: REACT_259780
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259780.1

SequenceSite3058
type: SequenceSite
position status: EQUAL
sequence position: 1458

SequenceSite3057
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite3056
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref11685
type: UnificationXref
id: 5621861
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621861

SequenceSite3055
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11684
type: UnificationXref
id: 5621860
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621860

SequenceSite3054
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref11687
type: UnificationXref
id: 5621866
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621866

SequenceSite3053
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11686
type: UnificationXref
id: 5621862
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621862

SequenceSite3052
type: SequenceSite
position status: EQUAL
sequence position: 1458

http://identifiers.org/pubmed/8709637
type: PublicationXref
id: 8709637
author: Löwenberg, B
author: Pouwels, K
author: Touw, IP
author: Hoefsloot, Lies H
author: van der Plas, DC
author: Smiers, F
db: Pubmed
title: Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
source: Leukemia 10:1317-25
year: 1996

SequenceSite19457
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19458
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19459
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22730
type: UnificationXref
id: 5624896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624896

UnificationXref22731
type: UnificationXref
id: 5624898
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624898

UnificationXref22732
type: UnificationXref
id: 5624900
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624900

UnificationXref22733
type: UnificationXref
id: 5624901
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624901

UnificationXref22734
type: UnificationXref
id: 5624902
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624902

UnificationXref22735
type: UnificationXref
id: 5624914
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624914

SequenceSite19450
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11672
type: UnificationXref
id: 5621870
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621870

SequenceSite3060
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref22737
type: UnificationXref
id: 5624915
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624915

UnificationXref11671
type: UnificationXref
id: Q21774
db: UniProt

UnificationXref22736
type: UnificationXref
id: REACT_253969
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253969.1

SequenceSite19452
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11670
type: UnificationXref
id: REACT_5412
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5412.3

SequenceSite3062
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref22739
type: UnificationXref
id: 5624909
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624909

SequenceSite19451
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3061
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref22738
type: UnificationXref
id: 5624906
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624906

SequenceSite19454
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19453
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19456
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19455
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3068
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref11679
type: UnificationXref
id: Q95QQ4
db: UniProt

SequenceSite3067
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11678
type: UnificationXref
id: REACT_4103
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4103.2

UnificationXref11677
type: UnificationXref
id: 111427
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111427

SequenceSite3069
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11676
type: UnificationXref
id: CHEBI:18381
db: ChEBI

SequenceSite3064
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref11675
type: UnificationXref
id: REACT_250604
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250604.1

SequenceSite3063
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref11674
type: UnificationXref
id: 5621873
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621873

SequenceSite3066
type: SequenceSite
position status: EQUAL
sequence position: 1458

UnificationXref11673
type: UnificationXref
id: 5621871
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621871

SequenceSite3065
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref22746
type: UnificationXref
id: 5624927
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624927

UnificationXref22745
type: UnificationXref
id: O01991
db: UniProt

UnificationXref22744
type: UnificationXref
id: REACT_245148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245148.1

UnificationXref22743
type: UnificationXref
id: 5624923
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624923

UnificationXref22742
type: UnificationXref
id: 5624921
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624921

UnificationXref22741
type: UnificationXref
id: 5624913
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624913

UnificationXref22740
type: UnificationXref
id: 5624912
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624912

Pristanal
type: SmallMoleculeReference
name: ChEBI:49189 Pristanal
xref: UnificationXref8642

SequenceSite19480
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19481
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of APEX1(1-?)
type: Protein
data source: Provenance1
member physical entity: Q564V5
member physical entity: G5EBR7
xref: UnificationXref22383
cellular location: GO_0005654
comment: Reactome DB_ID: 5623643
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54137
data source: Provenance1
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: P54137
name: Endonuclease III-like protein 1
xref: UnificationXref22330
feature: FragmentFeature5690
cellular location: GO_0005654
comment: Reactome DB_ID: 5623595
display name: NTHL1

SequenceSite19488
type: SequenceSite
position status: EQUAL
sequence position: 1497

Q09615
type: Protein
entity reference: Q09615
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA repair protein REV1 ecNumber2.7.7.-/ecNumber
name: REV1_HUMAN
xref: UnificationXref22418
feature: FragmentFeature5692
cellular location: GO_0005654
comment: Reactome DB_ID: 5623614
display name: REV1

SequenceSite19489
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9N3T2
data source: Provenance1
name: Maturation factor 1
name: Q9N3T2
name: FEN1
name: Flap endonuclease-1
xref: UnificationXref22402
feature: FragmentFeature5691
cellular location: GO_0005654
comment: Reactome DB_ID: 5623652
display name: MF1

SequenceSite19486
type: SequenceSite
position status: EQUAL
sequence position: 1497

Q564V5
type: Protein
entity reference: Q564V5
data source: Provenance1
xref: UnificationXref22382
cellular location: GO_0005654
comment: Reactome DB_ID: 5623642

SequenceSite19487
type: SequenceSite
position status: EQUAL
sequence position: 1

G5EBR7
type: Protein
entity reference: G5EBR7
data source: Provenance1
xref: UnificationXref22380
cellular location: GO_0005654
comment: Reactome DB_ID: 5623640

SequenceSite19484
type: SequenceSite
position status: EQUAL
sequence position: 1497

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q9U1Y0
data source: Provenance1
name: Q9U1Y0
name: Note: the coordinates are copied over from Homo sapiens.
name: Methylated-DNA--protein-cysteine methyltransferase
name: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase)
xref: UnificationXref22456
feature: FragmentFeature5695
cellular location: GO_0005654
comment: Reactome DB_ID: 5621912
display name: MGMT

UnificationXref22749
type: UnificationXref
id: REACT_250680
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_250680.1

SequenceSite19485
type: SequenceSite
position status: EQUAL
sequence position: 1

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q2HQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Methylated-DNA--protein-cysteine methyltransferase
name: Q2HQK2
name: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase)
xref: UnificationXref22454
feature: FragmentFeature5694
cellular location: GO_0005654
comment: Reactome DB_ID: 5621910
display name: MGMT

SequenceSite19482
type: SequenceSite
position status: EQUAL
sequence position: 1497

Homologues of MGMT
type: Protein
data source: Provenance1
member physical entity: 6-O- methylguanine-DNA methyltransferase
xref: UnificationXref22457
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5621913

UnificationXref22747
type: UnificationXref
id: 5624929
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624929

SequenceSite19483
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: G5EFY1
data source: Provenance1
name: G5EFY1
name: DNA polymerase eta
name: Pol eta protein
xref: UnificationXref22436
feature: FragmentFeature5693
cellular location: GO_0005654
comment: Reactome DB_ID: 5623625
display name: POLH

UnificationXref22748
type: UnificationXref
id: 5624930
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624930

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93559
data source: Provenance1
name: HERPUD1
name: HERP1_HUMAN
name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
xref: UnificationXref22318
feature: FragmentFeature5689
cellular location: GO_0005789
comment: Reactome DB_ID: 5642758
display name: Q93559

UnificationXref22755
type: UnificationXref
id: 5624951
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624951

UnificationXref22754
type: UnificationXref
id: 5624950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624950

UnificationXref22757
type: UnificationXref
id: REACT_247574
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247574.1

UnificationXref22756
type: UnificationXref
id: 5624952
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624952

UnificationXref22751
type: UnificationXref
id: 5624938
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624938

SequenceSite19479
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22750
type: UnificationXref
id: 5624934
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624934

UnificationXref22753
type: UnificationXref
id: 5624946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624946

UnificationXref22752
type: UnificationXref
id: 5624942
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624942

UnificationXref11697
type: UnificationXref
id: 5621851
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621851

UnificationXref11698
type: UnificationXref
id: REACT_245211
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245211.1

UnificationXref11695
type: UnificationXref
id: 5621848
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621848

SequenceSite19470
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11696
type: UnificationXref
id: 5621849
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621849

SequenceSite3000
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3001
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3002
type: SequenceSite
position status: EQUAL
sequence position: 2322

UnificationXref11699
type: UnificationXref
id: 5621852
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621852

SequenceSite3003
type: SequenceSite
position status: EQUAL
sequence position: 30

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O16466
data source: Provenance1
name: O16466
name: WIPI1_HUMAN
name: WD repeat domain phosphoinositide-interacting protein 1
xref: UnificationXref22283
feature: FragmentFeature5682
cellular location: Golgi membrane
comment: Reactome DB_ID: 5642927
display name: WIPI1

SequenceSite3004
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite19475
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of YIF1A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22294
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5642832

SequenceSite19476
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11690
type: UnificationXref
id: REACT_229771
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229771.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: H2KYN5
data source: Provenance1
name: H2KYN5
name: WIPI1_HUMAN
name: WD repeat domain phosphoinositide-interacting protein 1
xref: UnificationXref22285
feature: FragmentFeature5683
cellular location: Golgi membrane
comment: Reactome DB_ID: 5642929
display name: WIPI1

SequenceSite19477
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q20913
data source: Provenance1
name: Protein YIF1A
name: Q20913
name: YIF1A_HUMAN
xref: UnificationXref22293
feature: FragmentFeature5685
cellular location: GO_0005789
comment: Reactome DB_ID: 5642831
display name: YIF1A

SequenceSite19478
type: SequenceSite
position status: EQUAL
sequence position: 1497

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2PJ77
data source: Provenance1
name: Q2PJ77
name: Protein YIF1A
name: YIF1A_HUMAN
xref: UnificationXref22291
feature: FragmentFeature5684
cellular location: GO_0005789
comment: Reactome DB_ID: 5642829
display name: YIF1A

SequenceSite19471
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11693
type: UnificationXref
id: REACT_3823
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3823.2

Homologues of DNAJC3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22307
cellular location: GO_0005788
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 5642877

UnificationXref22758
type: UnificationXref
id: 5652882
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652882

SequenceSite19472
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11694
type: UnificationXref
id: Q9GZH3
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O01960
data source: Provenance1
name: O01960
name: ZBT17_HUMAN
name: Zinc finger and BTB domain-containing protein 17
xref: UnificationXref22299
feature: FragmentFeature5686
cellular location: GO_0005654
comment: Reactome DB_ID: 5642949
display name: ZBTB17

UnificationXref22759
type: UnificationXref
id: REACT_245115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245115.1

SequenceSite19473
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11691
type: UnificationXref
id: CHEBI:15652
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P91189
data source: Provenance1
name: P91189
name: p58IPK
xref: UnificationXref22306
feature: FragmentFeature5688
cellular location: GO_0005788
comment: Reactome DB_ID: 5642876
display name: DNAJC3

SequenceSite19474
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11692
type: UnificationXref
id: 111584
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111584

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9N3E0
data source: Provenance1
name: p58IPK
name: Q9N3E0
xref: UnificationXref22304
feature: FragmentFeature5687
cellular location: GO_0005788
comment: Reactome DB_ID: 5642872
display name: DNAJC3

UnificationXref22764
type: UnificationXref
id: Q21643
db: UniProt

UnificationXref22763
type: UnificationXref
id: REACT_237603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237603.1

UnificationXref22762
type: UnificationXref
id: 5652880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652880

UnificationXref22761
type: UnificationXref
id: REACT_262178
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_262178.1

UnificationXref22768
type: UnificationXref
id: O18211
db: UniProt

UnificationXref22767
type: UnificationXref
id: 5628243
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628243

UnificationXref22766
type: UnificationXref
id: Q7Z2A5
db: UniProt

UnificationXref22765
type: UnificationXref
id: 5628241
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628241

SequenceSite3009
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3008
type: SequenceSite
position status: EQUAL
sequence position: 2322

UnificationXref22760
type: UnificationXref
id: 5652879
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652879

SequenceSite3007
type: SequenceSite
position status: EQUAL
sequence position: 30

http://identifiers.org/pubmed/18215623
type: PublicationXref
id: 18215623
author: Lustig, LR
author: Edwards, RH
author: Glowatzki, E
author: Grant, L
author: Weber, CM
author: Clause, A
author: Yoo, J
author: Noebels, JL
author: Seal, RP
author: Akil, O
author: Yi, E
author: Kandler, K
db: Pubmed
title: Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
source: Neuron 57:263-75
year: 2008

SequenceSite3006
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3005
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3014
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3015
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3012
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3013
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3010
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3011
type: SequenceSite
position status: EQUAL
sequence position: 30

http://identifiers.org/pubmed/9050246
type: PublicationXref
id: 9050246
author: Nikinmaa, M
db: Pubmed
title: Oxygen and carbon dioxide transport in vertebrate erythrocytes: an evolutionary change in the role of membrane transport
source: J Exp Biol 200:369-80
year: 1997

UnificationXref22769
type: UnificationXref
id: 5628247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628247

RelationshipXref2103
type: RelationshipXref
id: 5624675
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624675

UnificationXref22773
type: UnificationXref
id: 5628251
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628251

RelationshipXref2102
type: RelationshipXref
id: GO:0000225
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22772
type: UnificationXref
id: 5628250
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628250

RelationshipXref2101
type: RelationshipXref
id: GO:0043687
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22775
type: UnificationXref
id: 5628253
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628253

RelationshipXref2100
type: RelationshipXref
id: GO:0008612
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22774
type: UnificationXref
id: 5628252
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628252

RelationshipXref2107
type: RelationshipXref
id: GO:0004376
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22777
type: UnificationXref
id: G5ECN5
db: UniProt

RelationshipXref2106
type: RelationshipXref
id: 5624662
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624662

UnificationXref22776
type: UnificationXref
id: 5628237
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628237

RelationshipXref2105
type: RelationshipXref
id: GO:0016780
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22779
type: UnificationXref
id: 5628258
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628258

RelationshipXref2104
type: RelationshipXref
id: 5624652
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624652

UnificationXref22778
type: UnificationXref
id: 5628257
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628257

SequenceSite3017
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3016
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3019
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref22771
type: UnificationXref
id: 5628249
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628249

SequenceSite3018
type: SequenceSite
position status: EQUAL
sequence position: 2322

UnificationXref22770
type: UnificationXref
id: 5628248
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628248

SequenceSite3023
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3024
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite3025
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite3026
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite19490
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3020
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite19491
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3021
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite19492
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3022
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite19493
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15167709
type: PublicationXref
id: 15167709
author: Blanchard, RL
author: Buck, J
author: Freimuth, RR
author: Coughtrie, MW
author: Weinshilboum, RM
db: Pubmed
title: A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
source: Pharmacogenetics 14:199-211
year: 2004

SequenceSite19494
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19495
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2108
type: RelationshipXref
id: 5624681
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624681

SequenceSite19496
type: SequenceSite
position status: EQUAL
sequence position: 1497

RelationshipXref2109
type: RelationshipXref
id: 5624669
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624669

SequenceSite19497
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19498
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19499
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2119
type: RelationshipXref
id: GO:0004360
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1701
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19235232
comment: Serine biosynthesis starts from 3-phosphoglycerate, a glycolysis intermediate. Its dehydrogenation is catalysed by tetrameric phosphoglycerate dehydrogenase PHGDH. (Tabatabaie et al. 2009).

Evidence1702
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12633500
comment: The amino group needed for serine biosynthesis comes from glutamate. Its transfer onto 3-phosphonooxpyruvate is catalysed by the PSAT1 dimer which needs pyridoxal phosphate as cofactor. (Baek et al. 2003)

RelationshipXref2110
type: RelationshipXref
id: GO:0016254
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22780
type: UnificationXref
id: 5628259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628259

Evidence1703
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9188776
comment: Dephosphorylation of O-phospho-L-serine to L-serine proceeds through a phospho-enzyme intermediate of the catalysing phosphatase PSP (Collet et al. 1997).

UnificationXref22781
type: UnificationXref
id: 5628260
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628260

Evidence1704
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15021249
comment: L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).

UnificationXref22782
type: UnificationXref
id: 5631946
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631946

Evidence1700
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7883047
xref: http://identifiers.org/pubmed/19338303
xref: http://identifiers.org/pubmed/8294935
xref: http://identifiers.org/pubmed/15364907
comment: CCBL1 (KAT 1) catalyzes the reaction of glutamine and pyruvate to form 2-oxoglutaramate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

Evidence1709
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9165094
xref: http://identifiers.org/pubmed/11264579
xref: http://identifiers.org/pubmed/12269802
comment: Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.

RelationshipXref2117
type: RelationshipXref
id: 5635796
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635796

UnificationXref22787
type: UnificationXref
id: 5628211
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628211

RelationshipXref2118
type: RelationshipXref
id: GO:0006489
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22788
type: UnificationXref
id: 5628212
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628212

RelationshipXref2115
type: RelationshipXref
id: 5651228
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651228

UnificationXref22789
type: UnificationXref
id: 5628213
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628213

RelationshipXref2116
type: RelationshipXref
id: GO:0004168
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1705
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: These reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four amino acids for glucose synthesis under fasting conditions. These reactions also provide a means to collect nitrogen, both as ammonia and as amino groups, and direct it towards urea synthesis. Transamination, the conversion of an amino acid to the corresponding alpha-keto acid coupled to the conversion of a molecule of alpha-ketoglutarate to glutamate, is the first step in the catabolism of most amino acids. Transamination reactions are freely reversible so they also provide a means to balance concentrations of various amino acids and alpha-keto (2-oxo) acids in the cytosol.

RelationshipXref2113
type: RelationshipXref
id: 5651226
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651226

UnificationXref22783
type: UnificationXref
id: REACT_213537
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_213537.2

Evidence1706
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16141215
comment: Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Hutson and colleagues have argues that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue (Goto et al. 2005).

RelationshipXref2114
type: RelationshipXref
id: GO:0016628
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22784
type: UnificationXref
id: 5628208
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628208

Evidence1707
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16141215
comment: Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (2-oxoglutarate). The active enzyme is a homodimer (Goto et al. 2005).

RelationshipXref2111
type: RelationshipXref
id: GO:0006501
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22785
type: UnificationXref
id: 5628209
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628209

Evidence1708
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9165094
xref: http://identifiers.org/pubmed/11264579
xref: http://identifiers.org/pubmed/12269802
comment: Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.

RelationshipXref2112
type: RelationshipXref
id: GO:0016765
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22786
type: UnificationXref
id: 5628210
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628210

UnificationXref22792
type: UnificationXref
id: 5628224
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628224

UnificationXref22793
type: UnificationXref
id: 5628225
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628225

RelationshipXref2120
type: RelationshipXref
id: 5635978
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635978

UnificationXref22790
type: UnificationXref
id: 5628214
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628214

RelationshipXref2121
type: RelationshipXref
id: GO:0004343
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22791
type: UnificationXref
id: 5628222
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628222

RelationshipXref2126
type: RelationshipXref
id: 5635830
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635830

RelationshipXref2127
type: RelationshipXref
id: GO:0006048
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2128
type: RelationshipXref
id: GO:0004476
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22798
type: UnificationXref
id: 5628226
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628226

RelationshipXref2129
type: RelationshipXref
id: 5636828
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636828

UnificationXref22799
type: UnificationXref
id: 5628231
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628231

RelationshipXref2122
type: RelationshipXref
id: 5635992
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635992

UnificationXref22796
type: UnificationXref
id: 5628217
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628217

RelationshipXref2123
type: RelationshipXref
id: GO:0004610
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22797
type: UnificationXref
id: 5628221
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628221

RelationshipXref2124
type: RelationshipXref
id: 5635747
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635747

UnificationXref22794
type: UnificationXref
id: 5628215
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628215

RelationshipXref2125
type: RelationshipXref
id: GO:0003977
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22795
type: UnificationXref
id: 5628216
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628216

UnificationXref11603
type: UnificationXref
id: REACT_5071
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5071.2

UnificationXref11602
type: UnificationXref
id: 111284
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111284

UnificationXref11601
type: UnificationXref
id: CHEBI:17909
db: ChEBI

UnificationXref11600
type: UnificationXref
id: 5621902
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621902

UnificationXref11608
type: UnificationXref
id: 5623668
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623668

UnificationXref11609
type: UnificationXref
id: CHEBI:17345
db: ChEBI

UnificationXref11606
type: UnificationXref
id: 5623666
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623666

RelationshipXref2131
type: RelationshipXref
id: 5635811
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635811

UnificationXref11607
type: UnificationXref
id: REACT_238655
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238655.1

RelationshipXref2132
type: RelationshipXref
id: GO:0004475
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11604
type: UnificationXref
id: 5621903
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621903

UnificationXref11605
type: UnificationXref
id: 5623665
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623665

RelationshipXref2130
type: RelationshipXref
id: GO:0004615
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

RelationshipXref2135
type: RelationshipXref
id: GO:0004581
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2136
type: RelationshipXref
id: 5635854
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635854

RelationshipXref2133
type: RelationshipXref
id: 5635883
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635883

RelationshipXref2134
type: RelationshipXref
id: GO:0009298
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2139
type: RelationshipXref
id: 5635784
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635784

RelationshipXref2137
type: RelationshipXref
id: GO:0018279
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2138
type: RelationshipXref
id: GO:0003975
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

RelationshipXref2140
type: RelationshipXref
id: GO:0004577
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2141
type: RelationshipXref
id: 5635836
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635836

RelationshipXref2142
type: RelationshipXref
id: GO:0004578
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2143
type: RelationshipXref
id: 5635869
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635869

RelationshipXref2144
type: RelationshipXref
id: GO:0000033
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2145
type: RelationshipXref
id: 5635842
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635842

RelationshipXref2146
type: RelationshipXref
id: GO:0000009
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2147
type: RelationshipXref
id: 5635980
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635980

RelationshipXref2148
type: RelationshipXref
id: GO:0000026
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2149
type: RelationshipXref
id: 5635753
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635753

UnificationXref11620
type: UnificationXref
id: CHEBI:17284
db: ChEBI

UnificationXref11621
type: UnificationXref
id: 111292
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111292

UnificationXref11624
type: UnificationXref
id: REACT_238439
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238439.1

UnificationXref11625
type: UnificationXref
id: CHEBI:18349
db: ChEBI

UnificationXref11622
type: UnificationXref
id: REACT_4144
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4144.2

UnificationXref11623
type: UnificationXref
id: 5621905
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621905

http://identifiers.org/pubmed/8365415
type: PublicationXref
id: 8365415
author: Miyasaka, Hitoshi
author: Li, Steven S
author: Choudhury, Barun K
author: Hou, Esther W
db: Pubmed
title: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein
source: Eur. J. Biochem. 216:343-52
year: 1993

RelationshipXref2159
type: RelationshipXref
id: 5635790
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635790

RelationshipXref2158
type: RelationshipXref
id: 5635773
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635773

RelationshipXref2157
type: RelationshipXref
id: 5635817
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635817

RelationshipXref2156
type: RelationshipXref
id: GO:0004583
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2155
type: RelationshipXref
id: 5635802
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635802

UnificationXref11629
type: UnificationXref
id: 5621886
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621886

RelationshipXref2154
type: RelationshipXref
id: GO:0000030
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11628
type: UnificationXref
id: Q20143
db: UniProt

RelationshipXref2153
type: RelationshipXref
id: 5635860
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635860

UnificationXref11627
type: UnificationXref
id: REACT_5626
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5626.2

RelationshipXref2152
type: RelationshipXref
id: 5635762
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635762

UnificationXref11626
type: UnificationXref
id: 111338
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111338

RelationshipXref2151
type: RelationshipXref
id: 5635848
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635848

RelationshipXref2150
type: RelationshipXref
id: GO:0034202
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11610
type: UnificationXref
id: 113578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113578

UnificationXref11611
type: UnificationXref
id: REACT_2761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2761.1

UnificationXref11612
type: UnificationXref
id: 5623669
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623669

UnificationXref11613
type: UnificationXref
id: CHEBI:17202
db: ChEBI

UnificationXref11614
type: UnificationXref
id: 29602
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29602

RelationshipXref2167
type: RelationshipXref
id: GO:0003980
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2166
type: RelationshipXref
id: 5637675
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637675

RelationshipXref2169
type: RelationshipXref
id: 5639200
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639200

RelationshipXref2168
type: RelationshipXref
id: 5636975
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636975

UnificationXref11616
type: UnificationXref
id: 5623667
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623667

RelationshipXref2163
type: RelationshipXref
id: GO:0033919
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11615
type: UnificationXref
id: REACT_2342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2342.1

RelationshipXref2162
type: RelationshipXref
id: 5636863
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636863

UnificationXref11618
type: UnificationXref
id: REACT_254661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254661.1

RelationshipXref2165
type: RelationshipXref
id: GO:0004559
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11617
type: UnificationXref
id: 5623670
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623670

RelationshipXref2164
type: RelationshipXref
id: 5636855
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636855

UnificationXref11619
type: UnificationXref
id: 5623671
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623671

RelationshipXref2161
type: RelationshipXref
id: GO:0004573
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2160
type: RelationshipXref
id: GO:0006488
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref11646
type: UnificationXref
id: REACT_251947
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251947.1

UnificationXref11647
type: UnificationXref
id: CHEBI:28843
db: ChEBI

UnificationXref11644
type: UnificationXref
id: 5621892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621892

UnificationXref11645
type: UnificationXref
id: 5621894
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621894

UnificationXref11642
type: UnificationXref
id: REACT_2513
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2513.2

UnificationXref11643
type: UnificationXref
id: Q19311
db: UniProt

UnificationXref11640
type: UnificationXref
id: CHEBI:18413
db: ChEBI

UnificationXref11641
type: UnificationXref
id: 111369
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111369

RelationshipXref2179
type: RelationshipXref
id: 5638551
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638551

http://identifiers.org/pubmed/20869317
type: PublicationXref
id: 20869317
author: Shastri, N
author: Blanchard, N
db: Pubmed
title: Topological journey of parasite-derived antigens for presentation by MHC class I molecules
source: Trends Immunol 31:414-21
year: 2010

RelationshipXref2178
type: RelationshipXref
id: GO:0008455
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2177
type: RelationshipXref
id: 5638545
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638545

RelationshipXref2172
type: RelationshipXref
id: GO:0004571
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2171
type: RelationshipXref
id: 5638295
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638295

RelationshipXref2170
type: RelationshipXref
id: GO:0005537
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2176
type: RelationshipXref
id: GO:0004572
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2175
type: RelationshipXref
id: 5638330
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638330

UnificationXref11649
type: UnificationXref
id: REACT_4927
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4927.2

RelationshipXref2174
type: RelationshipXref
id: GO:0003827
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11648
type: UnificationXref
id: 111370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111370

RelationshipXref2173
type: RelationshipXref
id: 5638313
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638313

UnificationXref11633
type: UnificationXref
id: 419151
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=419151

UnificationXref11634
type: UnificationXref
id: REACT_18590
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18590.3

UnificationXref11635
type: UnificationXref
id: CHEBI:18272
db: ChEBI

UnificationXref11636
type: UnificationXref
id: 111354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111354

UnificationXref11630
type: UnificationXref
id: 5621898
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621898

UnificationXref11631
type: UnificationXref
id: REACT_229430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229430.1

UnificationXref11632
type: UnificationXref
id: CHEBI:15637
db: ChEBI

RelationshipXref2190
type: RelationshipXref
id: GO:0036066
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref304
type: RelationshipXref
id: GO:0003834
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref305
type: RelationshipXref
id: 5638532
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638532

RelationshipXref302
type: RelationshipXref
id: GO:0050253
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref303
type: RelationshipXref
id: 5638514
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638514

RelationshipXref300
type: RelationshipXref
id: GO:0070290
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref301
type: RelationshipXref
id: 5648387
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648387

RelationshipXref2189
type: RelationshipXref
id: 5651769
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651769

RelationshipXref2188
type: RelationshipXref
id: GO:0016757
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref309
type: RelationshipXref
id: 5649314
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5649314

RelationshipXref308
type: RelationshipXref
id: GO:0004033
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref307
type: RelationshipXref
id: 5651721
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651721

RelationshipXref306
type: RelationshipXref
id: GO:0016702
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2181
type: RelationshipXref
id: 5639206
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5639206

RelationshipXref2180
type: RelationshipXref
id: GO:0008424
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2183
type: RelationshipXref
id: 5638557
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638557

RelationshipXref2182
type: RelationshipXref
id: GO:0030144
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11638
type: UnificationXref
id: 5621896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621896

RelationshipXref2185
type: RelationshipXref
id: 5638576
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5638576

UnificationXref11637
type: UnificationXref
id: REACT_3395
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3395.2

RelationshipXref2184
type: RelationshipXref
id: GO:0003831
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref2187
type: RelationshipXref
id: 5651783
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5651783

UnificationXref11639
type: UnificationXref
id: REACT_244608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244608.1

RelationshipXref2186
type: RelationshipXref
id: GO:0046922
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1877
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10224133
comment: PAP is generated as a byproduct of sulfonation reactions in vivo; its hydrolysis to AMP and orthophosphate returns its constituents to the pool of molecules available for cytosolic nucleotide metabolism. Bisphosphate 3'-nucleotidase 1catalyzes this reaction efficiently in vitro; whether other nucleotidases also play a role in PAP breakdown in vivo is unknown.

Evidence1878
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15167709
xref: http://identifiers.org/pubmed/12372849
xref: http://identifiers.org/pubmed/16322073
xref: http://identifiers.org/pubmed/9034160
xref: PublicationXref3029
xref: http://identifiers.org/pubmed/11154739
xref: http://identifiers.org/pubmed/10503886
comment: Two groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfonated acceptor and 3-phosphoadenosine 5-phosphate (PAP). One is localized to the Golgi apparatus and mediates the sulfonation of proteoglycans. The second, annotated here, is cytosolic and mediates the sulfonation of a diverse array of small molecules, increasing their solubilities in water and modifying their physiological functions. There are probably thirteen or more human cytosolic SULT enzymes; eleven of these have been purified and characterized enzymatically, and are annotated here (Blanchard et al. 2004; Gamage et al. 2005). These enzymes appear to be active as dimers. Their substrate specificities are typically broad, and not related in an obvious way to their structures; indeed, apparently orthologous human and rodent SULT enzymes can have different substrate specificities (Glatt 2000), and none has been exhaustively characterized. The substrates listed in the table and annotated here are a sample of the known ones, chosen to indicate the range of activity of these enzymes and to capture some of their known physiologically important targets. Absence of a small molecule - enzyme pair from the table, however, may only mean that it has not yet been studied.

Formation of a pool of free 40S subunits
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1848
pathway component: BiochemicalReaction1847
evidence: Evidence2570
xref: UnificationXref20786
xref: UnificationXref20785
pathway order: PathwayStep2551
pathway order: PathwayStep2552
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

Evidence1879
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref3029
comment: At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of '6-Methylmercaptopurine', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of '6-Mercaptopurine', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present. This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.

Evidence1873
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8185618
xref: http://identifiers.org/pubmed/7779757
xref: http://identifiers.org/pubmed/7678732
comment: Sulfonation of estrone is catalyzed by SULT1E1 (Aksoy et al. 1994; Falany et al. 1995), and also by SULT2A1 (Comer et al. 1993), although the efficiency of SULT2A1 catalysis is unknown.

Evidence1874
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11457664
xref: http://identifiers.org/pubmed/8185618
xref: http://identifiers.org/pubmed/2268288
comment: Sulfonation of dehydroepiandrosterone (DHEA) is catalyzed by SULT1E1 (Aksoy et al. 1994), SULT2A1 (Radominska et al. 1990) and the a and b isoforms of SULT2B1 (Meloche and Falany 2001).

Evidence1875
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2268288
comment: Sulfonation of lithocholate is catalyzed by SULT2A1 (Radominska et al. 1990).

Evidence1876
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2268288
comment: Sulfonation of taurolithocholate is catalyzed by SULT2A1 (Radominska et al. 1990).

Evidence1870
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11416019
xref: http://identifiers.org/pubmed/12730293
xref: http://identifiers.org/pubmed/12145317
comment: The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).

Evidence1872
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11457664
xref: http://identifiers.org/pubmed/12145317
comment: The sulfonation of pregnenolone (PREG) is catalyzed by both the a and b isoforms of SULT2B1, although the a isoform is more active in assays in vitro (Fuda et al. 2002; Meloche and Falany 2001).

Evidence1871
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11416019
comment: The sulfonation of 27-hydroxycholesterol (27HCHOL) is catalyzed by both the a and b isoforms of SULT2B1 (Javitt et al. 2001).

RelationshipXref341
type: RelationshipXref
id: 5626415
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626415

RelationshipXref340
type: RelationshipXref
id: GO:0004558
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref343
type: RelationshipXref
id: GO:0000016
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref342
type: RelationshipXref
id: 5626436
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626436

RelationshipXref345
type: RelationshipXref
id: GO:0004575
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref344
type: RelationshipXref
id: 5626427
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626427

RelationshipXref347
type: RelationshipXref
id: GO:0004555
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref346
type: RelationshipXref
id: 5626429
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626429

RelationshipXref349
type: RelationshipXref
id: GO:0044245
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref348
type: RelationshipXref
id: 5626406
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626406

RelationshipXref339
type: RelationshipXref
id: 5626366
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626366

Evidence1888
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16081649
xref: http://identifiers.org/pubmed/20085333
xref: http://identifiers.org/pubmed/12211029
xref: http://identifiers.org/pubmed/10587441
xref: http://identifiers.org/pubmed/22522127
xref: http://identifiers.org/pubmed/10329152
xref: http://identifiers.org/pubmed/8182750
xref: http://identifiers.org/pubmed/9839448
xref: http://identifiers.org/pubmed/20083122
xref: http://identifiers.org/pubmed/21668448
xref: http://identifiers.org/pubmed/16548513
xref: http://identifiers.org/pubmed/21106529
xref: http://identifiers.org/pubmed/9551553
xref: http://identifiers.org/pubmed/8431482
xref: http://identifiers.org/pubmed/8331657
xref: http://identifiers.org/pubmed/16298388
xref: http://identifiers.org/pubmed/11327815
xref: http://identifiers.org/pubmed/12627223
xref: http://identifiers.org/pubmed/8203914
xref: http://identifiers.org/pubmed/12042665
xref: http://identifiers.org/pubmed/10783391
comment: The glutathione S-transferases (GSTs) catalyze the nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulphur atom. Their substrates include halogenonitrobenzenes, arene oxides, quinones, and alpha, beta-unsaturated carbonyls. Three major families of proteins are widely distributed in nature. Two of these, the cytosolic and mitochondrial GST, comprise soluble enzymes that are only distantly related whilst the third family comprises microsomal GST, referred to as membrane-associated proteins in eicosanoid and glutathione (MAPEG) metabolism. At least 16 cytosolic GST subunits exist in human which are all in a dimeric form. Based on amino acid sequence similarities, seven classes of cytosolic GST are recognized in mammalian species; Alpha, Mu, Pi, Sigma, Theta, Omega, and Zeta (25). As well as being homodimers, the Alpha and Mu classes are also able to form heterodimers so a large number of isozymes are possible from all cytosolic GST subunits (Sinning et al. 1993, LeTrong et al. 2002, Ahmad et al. 1993, Pastore et al. 1998, Tars et al. 2010, Bruns et al. 1999, Balogh et al. 2010, Morel et al. 2002, Li et al. 2005, Patskovsky et al. 2006, Raghunathan et al. 1994, Patskovsky et al. 1999, Comstock et al. 1994, Board et al. 2000, Zhou et al. 2011, Zhou et al. 2012, Sun et al. 2011, Tars et al. 2006, Rossjohn et al. 1998, Polekhina et al. 2001, Inoue et al. 2003). Typical electrophilic substrates are chosen as examples for which the majority of the cytosolic GST isozymes act on.

Evidence1889
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref3029
comment: Glutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are encoded by at least 5 gene families (alpha, mu, pi, theta and zeta GST) whereas membrane-bound enzymes are encoded by single genes. Soluble GSTs are homo- or hetero-dimeric enzymes (approximately 25KDa subunits) which can act on a wide range of endogenous and exogenous electrophiles. GSTs mediate conjugation using glutathione (GSH), a tripeptide synthesized from its precursor amino acids gamma-glutamate, cysteine and glycine. A generalized reaction is RX + GSH -> HX + GSR Glutathione conjugates are excreted in bile and converted to cysteine and mercapturic acid conjugates in the intestine and kidneys. GSH is the major, low molecular weight, non-protein thiol synthesized de novo in mammalian cells. As well as taking part in conjugation reactions, GSH also has antioxidant ability and can metabolize endogenous and exogenous compounds. The nucleophilic GSH attacks the electrophilic substrate forming a thioether bond between the cysteine residue of GSH and the electrophile. The result is generally a less reactive and more water-soluble conjugate that can be easily excreted. In some cases, GSTs can activate compounds to reactive species such as certain haloalkanes and haloalkenes. Substrates for GSTs include epoxides, alkenes and compounds with electrophilic carbon, sulfur or nitrogen centres. There are two types of conjugation reaction with glutathione: displacement reactions where glutathione displaces an electron-withdrawing group and addition reactions where glutathione is added to activated double bond structures or strained ring systems.

Evidence1886
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17932939
xref: http://identifiers.org/pubmed/18515354
comment: Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al, 2008) can catalyzes the formation of 5-oxoproline from gamma-glutamyl-amino acid products and thus can play a role in glutathione homeostasis (Oakley et al, 2008).

Evidence1887
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053703
comment: The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).

Evidence1884
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7646467
comment: In the second step in the formation of glutathione, gamma-glutamylcysteine ligates with glycine to form glutathione (Gali and Board, 1995; ).

Evidence1885
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19463
xref: http://identifiers.org/pubmed/18357469
xref: http://identifiers.org/pubmed/2573352
comment: Extracellular glutathione can be hydrolyzed to give cysteinylglycine (Cys-Gly) and gamma glutamate, which, in the presence of amino acids, can form a gamma-glutamate:AA product (Heisterkamp et al, 2008). This hydrolysis provides cells with a cysteine supply and contributes to the maintainance of intracellular glutathione levels (Tate and Ross, 1977; Pawlak et al, 1989).

Evidence1883
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17932939
xref: http://identifiers.org/pubmed/18515354
comment: Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al, 2008) catalyzes the formation of 5-oxoproline from gamma-glutamylcysteine and thus, may play a role in glutathione homeostasis (Oakley et al, 2008).

Evidence1882
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9516961
comment: 5-oxoprolinase catalyzes the cleavage of 5-oxoproline to form L-glutamate, coupled to the hydrolysis of ATP to ADP and inorganic phosphate (Chen et al, 1998).

Evidence1881
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15130560
xref: http://identifiers.org/pubmed/10898761
xref: http://identifiers.org/pubmed/10331075
xref: PublicationXref3029
comment: Methylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the second most widely used enzyme substrate after ATP and is involved in a wide range of important biological processes. SAM is sythesized from methionine's reaction with ATP, catalyzed by methionine adenosyltransferase (MAT). There are two genes, MAT1A and MAT2A, which encode for two homologous MAT catalytic subunits, 1 and 2. During conjugation with nucleophilic substrates, the methyl group attached to the sulfonium ion of SAM is transferred to the substrate forming the conjugate. SAM, having lost the methyl moiety, is converted to S-adenosylhomocysteine (SAH). SAH can be hydrolyzed to form adenosine and homocysteine. Homocysteine can either be converted to glutathione or methylated to form methionine, thus forming the starting point for SAM synthesis and completing the cycle. Fuctional groups attacked are phenols, catechols, aliphatic and aromatic amines and sulfhydryl-containing groups. The enzymes that catalyze the transfer of the methyl group to these functional groups are the methyltransferases (MT). MTs are small, cytosolic, monomeric enzymes that utilize SAM as a methyl donor. There are many MTs but the best studied ones are named on the basis of their prototypical substrates: COMT (catechol O-methyltransferase), TPMT (thiopurine methyltransferase), TMT (thiol methyltransferase), HNMT (histamine N-methyltransferase) and NNMT (nicotinamide N-methyltransferase). An example of each enzyme mentioned is given. In each case, a typical substrate for the enzyme is shown.

http://identifiers.org/pubmed/10582339
type: PublicationXref
id: 10582339
author: Linnekin, D
db: Pubmed
title: Early signaling pathways activated by c-Kit in hematopoietic cells
source: Int J Biochem Cell Biol 31:1053-74
year: 1999

Evidence1880
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Pyridine is a typical substrate for Nicotinamide N-methyltransferase

RelationshipXref330
type: RelationshipXref
id: 5648069
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648069

http://identifiers.org/pubmed/6696436
type: PublicationXref
id: 6696436
author: Freemont, PS
author: Fothergill, LA
author: Dunbar, B
db: Pubmed
title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments
source: Arch Biochem Biophys 228:342-52
year: 1984

RelationshipXref334
type: RelationshipXref
id: 5648168
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648168

RelationshipXref333
type: RelationshipXref
id: 5648163
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5648163

RelationshipXref332
type: RelationshipXref
id: 5647855
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5647855

RelationshipXref331
type: RelationshipXref
id: 5647996
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5647996

RelationshipXref338
type: RelationshipXref
id: GO:0004556
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref337
type: RelationshipXref
id: GO:0006103
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref336
type: RelationshipXref
id: 5637598
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637598

RelationshipXref335
type: RelationshipXref
id: GO:0051990
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref328
type: RelationshipXref
id: GO:0022400
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref329
type: RelationshipXref
id: GO:0007603
db: GENE ONTOLOGY
relationship type: MI:0359

SRP-dependent cotranslational protein targeting to membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1866
pathway component: BiochemicalReaction1863
pathway component: BiochemicalReaction1862
pathway component: BiochemicalReaction1865
pathway component: BiochemicalReaction1864
evidence: Evidence2597
xref: UnificationXref20988
xref: UnificationXref20987
xref: RelationshipXref2080
pathway order: PathwayStep2579
pathway order: PathwayStep2578
pathway order: PathwayStep2575
pathway order: PathwayStep2577
pathway order: PathwayStep2576
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

Evidence1895
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19463
xref: http://identifiers.org/pubmed/18357469
xref: http://identifiers.org/pubmed/2573352
comment: To be excreted in urine, glutathione conjugates undergo several hydrolysis steps to form mercapturic acids which are readily excreted. The first step is the hydrolysis of a gamma-glutamyl residue from the conjugate catalysed by gamma-glutamyltransferases (GGTs). These are membrane-bound, heterodimeric enzymes composed of light and heavy peptide chains. GGT1 and 2 are well characterised while GGT3P, 5, 6 and 7 are putative transferases. Extracellular glutathione or its conjugates can be hydrolysed to give cysteinylglycine (CG, or CG conjugates) and free glutamate (L-Glu) (Heisterkamp et al. 2008, Tate & Ross 1977, Pawlak et al. 1989).

Evidence1896
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12933810
comment: Aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acetylated amino acids and N-acetylcysteine-S-conjugates (Lindner et al. 2003). They are functional as dimers and utilise zinc as a cofactor.

http://identifiers.org/pubmed/18268517
type: PublicationXref
id: 18268517
author: Lew, AM
author: Lin, ML
author: Villadangos, JA
author: Zhan, Y
db: Pubmed
title: The cell biology of cross-presentation and the role of dendritic cell subsets
source: Immunol Cell Biol 86:353-62
year: 2008

Evidence1897
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9675258
xref: http://identifiers.org/pubmed/12435844
xref: http://identifiers.org/pubmed/19514968
xref: http://identifiers.org/pubmed/23599745
xref: PublicationXref3088
comment: Aflatoxins are among the principal mycotoxins produced as secondary metabolites by the molds Aspergillus flavus and Aspergillus parasiticus that contaminate economically important food and feed crops (Wild & Turner 2002). Aflatoxin B1 (AFB1) is the most potent naturally occurring carcinogen known and is also an immunosuppressant. It is a potent hepatocarcinogenic agent in many species, and has been implicated in the etiology of human hepatocellular carcinoma. Poultry, especially turkeys, are extremely sensitive to the toxic and carcinogenic action of AFB1 present in animal feed, resulting in multi-million dollar losses to the industry. Discerning the biochemical and molecular mechanisms of this extreme sensitivity of poultry to AFB1 will help with the development of new strategies to increase aflatoxin resistance (Rawal et al. 2010, Diaz & Murcia 2011). AFB1 has one major genotoxic metabolic fate, conversion to AFXBO, and several others that are less mutagenic but that can still be quite toxic, causing [X, Y, and Z]. AFB1 can be oxidised to the toxic AFB1 exo 8,9 epoxide (AFXBO) product by several cytochrome P450 enzymes, especially P450 3A4 in the liver. This 8,9 epoxide can react with the N7 atom of a guanyl base of DNA to produce adducts by intercalating between DNA base pairs. The exo epoxide is unstable in solution, however, and can react spontaneously to form a diol that is no longer reactive with DNA. The diol product in turn undergoes base-catalysed rearrangement to a dialdehyde that can react with protein lysine residues. AFB1 can also be metabolised to products (AFQ1, AFM1, AFM1E) which have far less genotoxic consequences than AFB1. The main route of detoxification of AFB1 is conjugation of its reactive 8,9-epoxide form with glutathione (GSH). This reaction is carried out by trimeric glutathione transferases (GSTs), providing a chemoprotective mechanism against toxicity. Glutathione conjugates are usually excreted as mercapturic acids in urine (Guengerich…

Evidence1898
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref3023
comment: All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat solubility) is also the main reason organisms have developed mechanisms that convert them to hydrophilic (favours water solubility) compounds which are readily excreted via bile and urine. Otherwise, lipophilic chemicals would accumulate in the body and overwhelm defense mechanisms. This process is called biotransformation and is catalyzed by enzymes mainly in the liver of higher organisms but a number of other organs have considerable ability to process xenobiotica such as kidneys, gut and lungs. As well as xenobiotics, many endogenous compounds are commonly eliminated by this process. This mechanism is of ancient origin and a major factor for its development in animals is plants. Most animals are plant eaters and thus are subject to a huge variety of chemical compounds which plants produce to stop themselves being eaten. This complex set of enzymes have several features which make them ideal for biotransformation; (1) metabolites of the parent chemical are usually made more water soluble so it favours rapid excretion via bile and urine (2) the enzymes possess broad and overlapping specificity to be able to deal with newly exposed chemicals (3) metabolites of the parent generally don't have adverse biological effects. In the real world however, all these criteria have exceptions. Many chemicals are transformed into reactive metabolites. In pharmacology, the metabolites of some parent drugs exert the desired pharmacological effect but in the case of polycyclic aromatic hydrocarbons (PAHs), which can undergo epoxidation, it results in the formation of an electrophile which can …

Evidence1899
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: As inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. Defects in Mitoferrin-1 and Mitoferrin-2 cause a reduction in mitochondrial iron acquisition and biogenesis of iron-sulfur clusters and heme.

Evidence1890
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11805192
xref: PublicationXref3029
comment: Phase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Although most conjugations result in pharmacological inactivation or detoxification, some can result in bioactivation. Most of the phase II enzymes are located in the cytosol except UDP-glucuronosyltransferases (UGT), which are microsomal. Phase II reactions are typically much faster than phase I reactions therefore the rate-limiting step for biotransformation of a compound is usually the phase I reaction. Phase II metabolism can deal with all the products of phase I metabolism, be they reactive (Type I substrate) or unreactive/poorly active (Type II substrate) compounds. With the exception of glutathione, the conjugating species needs to be made chemically reactive after synthesis. The availability of the cofactor in the synthesis may be a rate-limiting factor in some phase II pathways as it may prevent the formation of enough conjugating species to deal with the substrate or it's metabolite. As many substrates and/or their metabolites are chemically reactive, their continued presence may lead to toxicity.

Evidence1892
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7766804
comment: Aflatoxin B1 (AFB1) undergoes extensive oxidation, which is catalysed by cytochrome P450s. In addition to formation of the 8,9-oxide, oxidation by CYP1A2 yields a stable metabolite, aflatoxin M1 (AFM1), that is excreted in milk and urine (Ueng et al. 1995). AFM1 is less carcinogenic or mutagenic than AFB1, but is equally toxic.

Evidence1891
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8975785
xref: http://identifiers.org/pubmed/1643250
xref: http://identifiers.org/pubmed/3931076
comment: Metabolites that are formed from aflatoxin B1 (AFB1) include AFQ1, AFM1 and AFP1 (Gallagher et al. 1996). These metabolites and other naturally occurring aflatoxins (G1, B2 and G2) are poorer substrates for epoxidation and, consequently, are less mutagenic, carcinogenic and toxic than AFB1. AFB1 metabolites can be useful biomarkers of human exposure to aflatoxins and AFM1, AFQ1 and AFP1 have all been detected in human urine samples (Groopman et al. 1985). Cytochrome P450 3A4 and 3A5 are the predominant enzymes involved in AFQ1 (3-hydroxy aflatoxin) production (Raney et al. 1992).

Evidence1894
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7766804
xref: http://identifiers.org/pubmed/1504254
comment: Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFNBO). CYP3A4 and CYP1A2 can also produce aflatoxin B1-endo-8,9-epoxide (Raney et al. 1992, Ueng et al. 1995).

Evidence1893
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8975785
xref: http://identifiers.org/pubmed/16385575
comment: Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFXBO). This conversion is carried out by at least four P450s; 1A2, 3A4, 3A5 and 2A13. CYP3A4 mainly produces the exo form whereas CYP1A2 produces a racemic mixture of exo and endo forms (Gallagher et al. 1996, He et al. 2006).

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http://identifiers.org/pubmed/12356719
type: PublicationXref
id: 12356719
author: Tasanen, K
author: Tryggvason, K
author: Schäcke, H
author: Lee, DC
author: Fahrenholz, F
author: Sunnarborg, S
author: Mauch, C
author: Zigrino, P
author: Bruckner-Tuderman, L
author: Franzke, CW
author: Zhou, Z
db: Pubmed
title: Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
source: EMBO J 21:5026-35
year: 2002

http://identifiers.org/pubmed/12450384
type: PublicationXref
id: 12450384
author: Zhang, Y
author: Desharnais, J
author: Beardsley, GP
author: Wilson, IA
author: Greasley, SE
author: Boger, DL
db: Pubmed
title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
source: Biochemistry 41:14206-14215
year: 2002

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Evidence1834
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. Transport of these molecuels across lipid bilayer membranes is annotated separately as part of the module on "transmembrane transport of small molecules".

Evidence1833
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16702333
comment: The main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic. This group of reactions contains all processes that 1) break down sulfur amino acids, 2) interconvert between them, and 3) synthesize them from solved sulfide which comes from sulfate assimilation and reduction. Only plants and microorganisms employ all processes. Humans cannot de novo synthesize any sulfur amino acid, nor convert cysteine to methionine (Brosnan & Brosnan, 2006).

Evidence1836
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12474143
xref: http://identifiers.org/pubmed/9878253
xref: http://identifiers.org/pubmed/15863660
xref: http://identifiers.org/pubmed/15235026
comment: Heme A is the prosthetic group of cytochrome c oxidase, the terminal enzyme in the respiratory chain. It is formed by the action of cytochrome c oxidase assembly protein COX15 homolog (COX15) on heme O (Petruzzella et al. 1998, Antonicka et al. 2003). Defects in COX15 cause of mitochondrial complex IV deficiency (MT-C4D; MIM:220110), also called cytochrome c oxidase deficiency resulting in a disorder of the mitochondrial respiratory chain seen as heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs (Antonicka et al. 2003). Defects in COX15 also cause Leigh syndrome (LS; MIM:256000), an early-onset progressive neurodegenerative disorder characterised by the presence of focal, bilateral lesions in one or more areas of the central nervous system (Oquendo et al. 2004, Bugiani et al. 2005).

Evidence1835
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8078902
xref: http://identifiers.org/pubmed/9177788
comment: Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).

Evidence1830
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10585886
xref: http://identifiers.org/pubmed/4441366
comment: Sulfate leaves the mitochondrion with the help of the dicarboxylate carrier, via antiport with malate (Crompton et al. 1974, Fiemont et al. 1999)

Evidence1832
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20162368
comment: While in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulfide, have uses in other biological processes (Stipanuk & Ueki 2011).

Evidence1831
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20162368
comment: While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters. The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).

Evidence1838
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Porphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the name itself, porphyrin, is derived from the Greek word for purple. The aromatic character of porphyrins can be seen by NMR spectroscopy. Porphyrins readily combine with metals by coordinating them in the central cavity. Iron (heme) and magnesium (chlorophyll) are two well known examples although zinc, copper, nickel and cobalt form other known metal-containing phorphyrins. A porphyrin which has no metal in the cavity is called a free base. Some iron-containing porphyrins are called hemes (heme-containing proteins or hemoproteins) and these are found extensively in nature ie. hemoglobin. Hemoglobin is quantitatively the most important hemoprotein. The hemoglobin iron is the transfer site of oxygen and carries it in the blood all round the body for cell respiration. Other examples are cytochromes present in mitochondria and endoplasmic reticulum which takes part in electron transfer events, catalase and peroxidase whic protect the body against the oxidant hydrogen peroxide and tryptophan oxygenase which is present in intermediary metabolism. Hemoproteins are synthesized in all mammalian cells and the major sites are erythropoietic tissue and the liver. The processes by which heme is synthesized, transported, and metabolized are a critical part of human iron metabolism (Severance and Hamze 2009); here the core processes of heme biosynthesis and catabolism have been annotated.

Evidence1837
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10522552
xref: http://identifiers.org/pubmed/16839620
comment: Eight enzymes are involved in heme biosynthesis, four each in the mitochondria and the cytosol. The process starts in the mitochondria with the condensation of succinyl CoA (from the TCA cycle) and glycine to form 5-aminolevulinate (ALA). The next four steps take place in the cytosol. Two molecules of ALA are condensed to form the monopyrrole porphobilinogen (PBG). The next two steps convert four molecules of PBG into the cyclic tetrapyrrole uroporphyringen III, which is then decarboxylated into coproporphyrinogen III. The last three steps occur in the mitochondria and involve modifications to the tetrapyrrole side chains and finally, insertion of iron. In addition to these synthetic steps, a spontaneous cytosolic reaction allows the formation of uroporphyringen I which is then enzymatically decarboxylated to coproporphyrinogen I, which cannot be metabolized further in humans. Also, lead can inactivate ALAD, the enzyme that catalyzes PBG synthesis, and ferrochelatase, the enzyme that catalyzes heme synthesis. The porphyrias are disorders that arise from defects in the enzymes of heme biosynthesis. Defective pathway enzymes after ALA synthase result in accumulated substrates which can cause either skin problems, neurological complications, or both due to their toxicity in higher concentrations. They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction of the substrate. Each defect is described together with the reaction it affects.

Evidence1839
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11555828
comment: Cytochrome P450 1B1 (CYP1B1) can oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. CYP1B1 can also activate a range of procarcinogens. A specific substrate is the female sex hormone estradiol-17beta which is hydroxylated at position 4.

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comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619481

http://identifiers.org/pubmed/19303758
type: PublicationXref
id: 19303758
author: Hemmings, BA
author: Bozulic, L
db: Pubmed
title: PIKKing on PKB: regulation of PKB activity by phosphorylation
source: Curr Opin Cell Biol 21:256-61
year: 2009

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Evidence1847
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15454734
xref: http://identifiers.org/pubmed/8975785
comment: Aflatoxins are produced by the fungal molds Aspergillus flavus and Aspergillus parasiticus. Dietary contamination accounts for adverse health problems including liver cancer therby classifying aflatoxins as Group 1 carcinogens in humans. The B1 form of aflatoxin (AFB1) is especially carcinogenic in a number of species including humans. AFB1 requires microsomal oxidation to produce epoxides which are the cause of their toxic and carcinogenic effects. In humans, both CYP3A4 and CYP3A5 are able to produce epoxide stereoisomers of AFB1, the most potent being aflatoxin B1 exo-8,9-oxide (AFXBO) (Gallagher et al. 1996).

Evidence1846
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15365656
comment: The CYP3A family are the most abundantly expressed P450s in human liver, accounting for around 50% of xenobiotic drug metabolism. CYP3A4 is the most abundant member of the family and possesses broad specificity to a range of xenobiotics. Loperamide (LOP), an antidiarrheal, is mainly metabolized to desmethylloperamide (DLOP) through the N-demethylation pathway. This initial N-demethylation is carried out by CYP3A4.

Evidence1845
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: CYP1A2 oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. It is most active in catalyzing N-hydroxylation or N-dealkylation reactions.

Evidence1844
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1934265
xref: http://identifiers.org/pubmed/9111224
comment: Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.

Evidence1843
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8553685
comment: Caffeine is one of the world's most frequently consumed xenobiotic. The major source of caffeine comes from tea and coffee. Caffeine is extensively metabolized in humans with at least 17 metabolites formed in its biotransformation. CYP1A2 is a prominent enzyme in the formation of an important metabolite of caffeine (paraxanthine) by N3-demethylation.

Evidence1842
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12464245
xref: http://identifiers.org/pubmed/7217086
comment: A simple example of epoxidation is the oxidation of an alkene (olefin) to the epoxide (oxirane), catalysed by CYP1A1. Even the simplest of epoxides (ethylene oxide) can react with DNA and amino groups in a protein.

Evidence1841
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/16872679
comment: A number of CYPs take part in cholesterol biosynthesis and elimination, thus playing an important role in maintaining cholesterol homeostasis. Under normal physiological conditions, cholesterol intake (diet or synthesized de novo from acetyl CoA) equals cholesterol elimination (degraded to bile salts, secreted in bile and used in steroid hormone synthesis). These processes are under tight regulatory control and any disruption leads to increased cholesterol levels resulting in cardiovacular disease. The CYPs involved in cholesterol homeostasis could serve as potential targets for cholesterol-lowering drugs.

Evidence1840
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11856349
xref: http://identifiers.org/pubmed/2592361
comment: P450 11B2 (steroid 11 beta-hydroxylase) is a mitochondrial cytochrome P-450 enzyme necessary for cortisol biosynthesis.The synthesis of the most important glucocorticoid and mineralocorticoid hormones in humans (cortisol and aldosterone, respectively), take place in the adrenal gland. The 11?- and 18-hydroxylation of the substrate 11-deoxycorticosterone (DOC) leads to corticosterone (B)band 18-hydroxycorticosterone (18-OH-B), whose 18-oxidation yields aldosterone. CYP11B1 is also able to produce corticosterone from 11-deoxycorticosterone but it cannot convert corticosterone into aldosterone.

http://identifiers.org/pubmed/8787677
type: PublicationXref
id: 8787677
author: Schuster, VL
author: Kanai, N
author: Lu, R
author: Bao, Y
db: Pubmed
title: Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)
source: J Clin Invest 98:1142-9
year: 1996

Evidence1849
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/12369887
comment: Of the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.

Evidence1848
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9644715
comment: CYP3A7 is only expressed in fetal liver and not in adults. It has lower biotransformation capability than other members of the CYP3A family such as 3A4 or 3A5 but possesses a similar broad specificity. CYP3A7 plays a major role in fetal steroid hydroxylation, an example being the 6beta-hydroxylation of testosterone.

http://identifiers.org/pubmed/15809071
type: PublicationXref
id: 15809071
author: Ishibashi, K
author: Uchida, S
author: Ko, SB
author: Sasaki, S
author: Kuwahara, M
author: Rai, T
author: Itoh, T
db: Pubmed
title: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
source: Biochem Biophys Res Commun 330:832-8
year: 2005

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db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619464

RelationshipXref379
type: RelationshipXref
id: GO:0004743
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref370
type: RelationshipXref
id: 5619304
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619304

RelationshipXref373
type: RelationshipXref
id: GO:0004365
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref374
type: RelationshipXref
id: 5619403
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619403

RelationshipXref371
type: RelationshipXref
id: GO:0004807
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref372
type: RelationshipXref
id: 5619410
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619410

Evidence1852
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/16126164
xref: http://identifiers.org/pubmed/17786643
comment: Approximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental evidence to know that all these proteins get made and can catalyze CYP-like reactions in vitro, evidence of in vivo function and substrate specificity is insufficient to allow them to be placed in any of the classes in the functional scheme.

Evidence1851
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15548719
xref: http://identifiers.org/pubmed/11160876
comment: CYP3A43 belongs to the CYP3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards testosterone. Thus, CYP3A43 may be involved in the etiology of prostate cancer.

Evidence1854
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15987777
comment: Tamoxifen (TAM) is an antiestrogen and currently used extensively for breast cancer therapy. FMOs, especially FMO1 can N-oxidze TAM to tamoxifen N-oxide (TNO). TNO can be reduced back to TAM by the P450 system. TNO appears to be just as potent as TAM but with fewer side-effects so this metabolic cycling could play a part in the use of TNO in the treatment of breast cancer.

Evidence1853
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/12369887
xref: http://identifiers.org/pubmed/15128046
comment: The P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate specificity, acting upon xenobiotica and endogenous compounds. It is also called the mixed-function oxidase system, the P450 monooxygenases and the heme-thiolate protein system. All P450 enzymes are a group of heme-containing isozymes which are located on the membrane of the smooth endoplasmic reticulum. They can be found in all tissues of the human body but are most concentrated in the liver. The name "cytochrome P450" (CYP) is derived from the spectral absorbance maximum at 450nm when carbon monoxide binds to CYP in its reduced (ferrous, Fe2+) state. The basic reaction catalyzed by CYP is mono-oxygenation, that is the transfer of one oxygen atom from molecular oxygen to a substrate. The other oxygen atom is reduced to water during the reaction with the equivalents coming from the cofactor NADPH. The basic reaction is; RH (substrate) + O2 + NADPH + H+ = ROH (product) + H2O + NADP+ The end results of this reaction can be (N-)hydroxylation, epoxidation, heteroatom (N-, S-) oxygenation, heteroatom (N-, S-, O-) dealkylation, ester cleavage, isomerization, dehydrogenation, replacement by oxygen or even reduction under anaerobic conditions. The metabolites produced from these reactions can either be mere intermediates which have relatively little reactivity towards cellular sysytems and are readily conjugated, or, they can be disruptive to cellular systems. Indeed, inert compounds need to be prepared for conjugation and thus the formation of potentially reactive metabolites is in most cases unavoidable. There are 57 human CYPs (in 18 families and 42 subfamilies), mostly concentrated in the endoplasmic reticulum of liver cells although many tissues have them to some extent (Nelson DR et al, 2004). CYPs are grouped into 14 families according to their sequence similarity. General…

Evidence1856
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4195988
xref: http://identifiers.org/pubmed/5048998
comment: Trimethylamine (TMA) is present in the diet (in fish) but primarily formed in vivo from the breakdown of choline. It is N-oxidized by FMO3 in the liver, the major isoform active towards TMA Trimethylaminuria (âfish-odour syndromeâ) is a human genetic disorder characterized by an impaired ability to convert the malodourous TMA to its odourless N-oxide.

Evidence1855
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11744609
comment: Methimazole is a drug used to treat hyperthyroidism, a condition arising when the thyroid gland is producing too much thyroid hormone. FMO2 is able to the S-oxidized form of methimazole.

Evidence1858
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11468017
xref: http://identifiers.org/pubmed/6206782
comment: Polyamine oxidases (PAOs), like MAOs, are also FAD-dependant and form aldehydes and hydrogen peroxide. PAOs are approximately 60KDa in size, are monomers and are located in peroxisomes. They act on endogenous polyamines as well as some xenobiotics. The polyamines of the spermine and spermidine families are important physiologically as they mediate cell function and growth and also play a role in programmed cell death. The balance between biosynthesis, degradation and uptake of these polyamines is strictly controlled in cells and the PAO system is one of a set of enzymes that maintains this regulation.

Evidence1857
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15922018
xref: http://identifiers.org/pubmed/12951812
comment: Flavin-containing monooxygenases (FMOs) are the second family of microsomal oxidative enzymes with broad and overlapping specificity. The major reactions FMOs catalyze are nucleophilic hetero-atom compounds such as nitrogen, sulfur or phosphorus as the hetero-atom to form N-oxides, S-oxides or P-oxides respectively. Despite the functional overlap with cytochrome P450s, the mechanism of action differs. FMOs bind and activate molecular oxygen before the substrate binds to the enzyme (picture). They also require flavin adenosine dinucleotide (FAD) as a cofactor. Unlike cytochrome P450 enzymes, FMOs are heat-labile, a useful way to distinguish which enzyme system is at work for researchers studying metabolism. Also, FMOs are not inducible by substrates, unlike the P450 enzymes.\n(1) NADPH binds to the enzyme and reduces the prosthetic group FAD to FADH2. NADP+ remains bound to the enzyme.\n(2) Incorporation of molecular oxygen to form a hydroperoxide.\n(3) A peroxide oxygen is transferred to the substrate.\n(4) Water is released.\n(5) NADP+ dissociates returning the enzyme to its initial state.\n\nTo date, there are 6 isozymes of FMO (FMO1-6) in humans, the most prominent and active one being FMO3. The FMO6 gene does not encode for a functional enzyme although it has the greatest sequence similarity with FMO3 (71%), whilst the others range from 50-58% sequence similarity with FMO3. FMO1-3 are the ones that exhibit activity towards nucleophiles, the others are insignificant in this respect.

http://identifiers.org/pubmed/9499401
type: PublicationXref
id: 9499401
author: Morimoto, R I
author: Shi, Y
author: Mosser, D D
db: Pubmed
title: Molecular chaperones as HSF1-specific transcriptional repressors
source: Genes Dev. 12:654-66
year: 1998

Evidence1859
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11468017
xref: http://identifiers.org/pubmed/6206782
xref: http://identifiers.org/pubmed/9443166
comment: Human amine oxidases (AO) catalyze the oxidative deamination of biogenic amines (neurotransmitters such as serotonin, noradrenaline, the hormone adrenaline and polyamines such as the spermines) and xenobiotic amines (exogenous dietary tyramine and phenylethylamine). The basic reaction is the oxidative cleavage of the alpha-H to form an imine product with the concomitant reduction of a FAD cofactor. The imine product then hydrolyses to an aldehyde and ammonia (or amine for secondary and tertiary amine substrates). Reduced FAD is reoxidized to form hydrogen peroxide to complete the catalytic cycle. The reaction can be summarized as RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 The resultant hydrogen peroxide is the source of the most toxic free radical, the hydroxyl radical (.OH). This free radical is produced in the Fenton reaction with the use of ferrous (Fe2+) iron.

http://identifiers.org/pubmed/9499402
type: PublicationXref
id: 9499402
author: Van Etten, R L
author: Daniel, T O
author: Stein, E
author: Schoecklmann, H O
author: Schroff, A D
author: Cerretti, D P
author: Lane, A A
db: Pubmed
title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
source: Genes Dev. 12:667-78
year: 1998

RelationshipXref368
type: RelationshipXref
id: 5619428
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619428

RelationshipXref369
type: RelationshipXref
id: GO:0004332
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref364
type: RelationshipXref
id: 5624814
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624814

RelationshipXref365
type: RelationshipXref
id: GO:0003873
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref366
type: RelationshipXref
id: 5620511
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5620511

http://identifiers.org/pubmed/11684289
type: PublicationXref
id: 11684289
author: Villadangos, JA
db: Pubmed
title: Presentation of antigens by MHC class II molecules: getting the most out of them
source: Mol Immunol 38:329-46
year: 2001

RelationshipXref367
type: RelationshipXref
id: GO:0003872
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref360
type: RelationshipXref
id: GO:0015758
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref361
type: RelationshipXref
id: GO:0008645
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref362
type: RelationshipXref
id: GO:0004347
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref363
type: RelationshipXref
id: 5619443
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619443

Evidence1850
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/7922394
comment: Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidonic acid.

Evidence1865
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11322953
comment: The human gene SLC35D1 encodes the UDP-glucuronic acid transporter which transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen (Muraoka et al. 2001).

Evidence1864
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15044486
comment: UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Evidence1863
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17125408
xref: PublicationXref3023
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/12369887
comment: Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions. There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides.

Evidence1862
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3893466
xref: http://identifiers.org/pubmed/224930
xref: http://identifiers.org/pubmed/18110463
xref: http://identifiers.org/pubmed/10441588
xref: http://identifiers.org/pubmed/9982
xref: http://identifiers.org/pubmed/17567461
xref: http://identifiers.org/pubmed/2729894
comment: Ethanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep process first described by Racker (1949). First, in the cytosol, ethanol is oxidized to acetaldehyde, with the formation of NADH. Second, in the mitochondrion, acetaldehyde is oxidized to acetate with the formation of NADH. Finally, acetate in the mitochondrion can be condensed with coenzyme A to form acetyl CoA. Polymorphisms in the enzymes catalyzing the first two steps are associated with variation in the efficiency of alcohol catabolism in human populations (Chen et al. 1999; Lange et al. 1976; Jornvall 1985). The molecular mechanism by which cytosolic acetaldehyde enters the mitochondrial matrix is not known (Lemasters 2007). Cytosolic enzymes capable of oxidizing acetaldehyde to acetate have also been identified and characterized in vitro (Inoue et al. 1979) so a purely cytosolic pathway for ethanol oxidation to acetate and conversion to acetyl-CoA can be annotated. The role of this pathway in vivo is unclear, though limited attempts to correlate deficiencies in the cytosolic enzyme with alcohol intolerance have yielded suggestive data (Yoshida et al. 1989). Additional peroxisomal and microsomal pathways for the oxidation of ethanol to acetaldehyde have been described; their physiological significance is unclear and they are not annotated here.

Evidence1869
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10512730
xref: http://identifiers.org/pubmed/9463486
xref: http://identifiers.org/pubmed/11739018
xref: http://identifiers.org/pubmed/10199779
xref: http://identifiers.org/pubmed/11077054
xref: http://identifiers.org/pubmed/12039030
xref: http://identifiers.org/pubmed/8126143
comment: 3,5,3'-Triiodothyronine (T3) 4-sulfate is a major metabolite of T3 in humans (LoPresti and Nicoloff 1994), and seven SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), 2A1 (Li and Anderson 1999), and 4A1 (Sakakibara et al. 2002) can catalyze this reaction in vitro or in tissue culture model systems. All of these enzymes except SULT4A1 also catalyze the sulfonation of 3,3'-diiodothyronine (T2).

Evidence1868
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10512730
xref: http://identifiers.org/pubmed/9463486
xref: http://identifiers.org/pubmed/11739018
xref: http://identifiers.org/pubmed/10199779
xref: http://identifiers.org/pubmed/11077054
comment: Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).

Evidence1867
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref3029
xref: http://identifiers.org/pubmed/10836148
xref: http://identifiers.org/pubmed/14977861
comment: Glucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17) to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in phase II metabolism and accounts for approximately 35% of drug conjugation. UGTs are microsomal membrane-bound and catalyze the transfer of a glucuronate group of uridine diphosphoglucuronate (UDPGA, a co-substrate) to the functional group of specific substrates. UDPGA is synthesized from glucose-1-phosphate (G1P). G1P is required for glycolysis and is present in high concentrations in the cell, making it is unlikely to be a limiting factor in UDPGA synthesis. UDP is added to G1P to form UDP-glucose which is then dehydrogenated to form UDPGA. The basic reaction is UDP-Glucuronate + acceptor -> UDP + acceptor-beta-D-glucuronide The effect of this conjugation is to confer polarity to the substrate which can then be easily excreted in urine or bile. Functional groups acted on include hydroxyl, carboxylate, amino and sulfate groups. There are 2 families of UGTs, UGT1 and UGT2 which are further sub-divided into 3 subfamilies, UGT1A, UGT2A and UGT2B. There are more than 26 different isozymes in humans, of which 18 are functional proteins. They are composed of 527-530 residues and have a molecular weight of 50-57KDa. The UGT1 family comprises of 9 proteins (UGT1A1, 1A3-1A10) but only 5 have been isolated in humans. Example substrates which are glucuronidated are acetaminophen by UGT1A6 and bilirubin by UGT1A1. Members of the UGT2 subfamily are each encoded by their own genes, in contrast to UGT1As which are encoded at the UGT1 locus. Example substrates are morphine conjugation by UGT2B7 and androgenic steroid conjugation by UGT2B17. Xenobiotics conjugated with glucuronic acid can be substrates for beta-glucuronidase, an enzyme common in gut microflora. This enzyme can release the parent or phase I metabolite which can be reabsorbed. It can then either re-exert it's original eff…

Evidence1866
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17482904
comment: Glucose 1-phosphate and UTP are the precursors to UDP-glucuronate formation. After oxidation of the resultant complex, UDP-glucuronate is transported to the ER lumen.

RelationshipXref359
type: RelationshipXref
id: GO:0010827
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref357
type: RelationshipXref
id: GO:0004340
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref358
type: RelationshipXref
id: 5619382
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619382

RelationshipXref355
type: RelationshipXref
id: 5619366
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619366

RelationshipXref356
type: RelationshipXref
id: 5636002
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636002

RelationshipXref353
type: RelationshipXref
id: 5626453
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626453

RelationshipXref354
type: RelationshipXref
id: GO:0005355
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref351
type: RelationshipXref
id: 5626449
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626449

RelationshipXref352
type: RelationshipXref
id: GO:0015149
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref350
type: RelationshipXref
id: GO:0005353
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1860
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4065146
xref: http://identifiers.org/pubmed/10631996
xref: http://identifiers.org/pubmed/18196
comment: ALDH2 (aldehyde dehydrogenase) in the mitochondrial matrix catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Greenfield and Pietruszko 1977; Hempel et al. 1985). The active form of the enzyme is a tetramer (Ni et al. 1999).

Evidence1861
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10843999
comment: Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).

UnificationXref11498
type: UnificationXref
id: REACT_249145
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249145.1

UnificationXref11497
type: UnificationXref
id: 5619929
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619929

UnificationXref11499
type: UnificationXref
id: CHEBI:18012
db: ChEBI

UnificationXref11494
type: UnificationXref
id: P53588
db: UniProt

UnificationXref11493
type: UnificationXref
id: REACT_234657
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234657.1

UnificationXref11496
type: UnificationXref
id: 5619927
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619927

UnificationXref11495
type: UnificationXref
id: 5619926
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619926

UnificationXref11490
type: UnificationXref
id: 5619922
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619922

UnificationXref11492
type: UnificationXref
id: 5620494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5620494

UnificationXref11491
type: UnificationXref
id: 5620492
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5620492

RelationshipXref394
type: RelationshipXref
id: 5630605
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630605

RelationshipXref393
type: RelationshipXref
id: GO:0015172
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref396
type: RelationshipXref
id: GO:0004613
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref395
type: RelationshipXref
id: 5619524
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619524

RelationshipXref390
type: RelationshipXref
id: 5619557
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619557

RelationshipXref392
type: RelationshipXref
id: 5627703
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5627703

RelationshipXref391
type: RelationshipXref
id: GO:0015367
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref398
type: RelationshipXref
id: 5630647
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5630647

RelationshipXref397
type: RelationshipXref
id: 5619248
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619248

RelationshipXref399
type: RelationshipXref
id: GO:0015142
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/17296555
type: PublicationXref
id: 17296555
author: Komai, S
author: Kiyama, Y
author: Mizuno, H
author: Mitchell, KJ
author: Fujisawa, H
author: Kamiya, H
author: Manabe, T
author: Chédotal, A
author: Yagi, T
author: Hiromi, Y
author: Shimizu, M
author: Tsuboi, M
author: Sanbo, M
author: Suto, F
db: Pubmed
title: Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers
source: Neuron 53:535-47
year: 2007

Adrenoceptors
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1062
pathway component: BiochemicalReaction2128
evidence: Evidence3074
xref: UnificationXref23998
xref: UnificationXref23999
pathway order: PathwayStep1481
pathway order: PathwayStep3046
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

http://identifiers.org/pubmed/3539386
type: PublicationXref
id: 3539386
author: Wood, T
db: Pubmed
title: Physiological functions of the pentose phosphate pathway
source: Cell Biochem Funct 4:241-7
year: 1986

SequenceSite19300
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19301
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19302
type: SequenceSite
position status: EQUAL
sequence position: 717

http://identifiers.org/pubmed/11222639
type: PublicationXref
id: 11222639
author: Maness, PF
author: Thelen, K
author: Needham, LK
db: Pubmed
title: Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions
source: J Neurosci 21:1490-500
year: 2001

SequenceSite19308
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19307
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19309
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19304
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19303
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19306
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19305
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18678926
type: PublicationXref
id: 18678926
author: Rajnarayanan, RV
author: Cohly, HH
author: Isokpehi, R
db: Pubmed
title: Compartmentalization of aquaporins in the human intestine
source: Int J Environ Res Public Health 5:115-9
year: 2008

SequenceSite3191
type: SequenceSite
position status: EQUAL
sequence position: 51

SequenceSite3192
type: SequenceSite
position status: EQUAL
sequence position: 1108

SequenceSite3193
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3194
type: SequenceSite
position status: EQUAL
sequence position: 200

SequenceSite3190
type: SequenceSite
position status: EQUAL
sequence position: 1103

SequenceSite3199
type: SequenceSite
position status: EQUAL
sequence position: 1068

SequenceSite3195
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3196
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite3197
type: SequenceSite
position status: EQUAL
sequence position: 542

SequenceSite3198
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19349
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19347
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19348
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22602
type: UnificationXref
id: 109960
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109960

UnificationXref22603
type: UnificationXref
id: REACT_2556
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2556.2

UnificationXref22600
type: UnificationXref
id: 110303
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110303

UnificationXref22601
type: UnificationXref
id: REACT_5428
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5428.1

UnificationXref11568
type: UnificationXref
id: 73663
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73663

UnificationXref11567
type: UnificationXref
id: CHEBI:16389
db: ChEBI

SequenceSite3179
type: SequenceSite
position status: EQUAL
sequence position: 52

SequenceSite3178
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11569
type: UnificationXref
id: REACT_4901
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4901.2

SequenceSite3177
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11564
type: UnificationXref
id: REACT_183184
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_183184.3

SequenceSite3176
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11563
type: UnificationXref
id: 5653309
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653309

SequenceSite3175
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11566
type: UnificationXref
id: REACT_245682
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245682.1

SequenceSite3174
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11565
type: UnificationXref
id: 5652510
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652510

SequenceSite3173
type: SequenceSite
position status: EQUAL
sequence position: 52

SequenceSite19342
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11560
type: UnificationXref
id: REACT_209114
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209114.2

SequenceSite3172
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref22607
type: UnificationXref
id: REACT_261362
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261362.1

SequenceSite19341
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3171
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref22606
type: UnificationXref
id: 5652781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652781

SequenceSite19340
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11562
type: UnificationXref
id: REACT_206911
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206911.2

SequenceSite3170
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref22605
type: UnificationXref
id: REACT_229827
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229827.1

UnificationXref11561
type: UnificationXref
id: 5637582
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637582

UnificationXref22604
type: UnificationXref
id: 5623577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623577

SequenceSite19346
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19345
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19344
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22609
type: UnificationXref
id: REACT_5433
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5433.1

SequenceSite19343
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22608
type: UnificationXref
id: 110295
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110295

SequenceSite19336
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19337
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19338
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19339
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22610
type: UnificationXref
id: 5623578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623578

UnificationXref22611
type: UnificationXref
id: REACT_258982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258982.1

UnificationXref22612
type: UnificationXref
id: 5652782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652782

UnificationXref22613
type: UnificationXref
id: REACT_242854
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242854.1

UnificationXref22614
type: UnificationXref
id: 5623579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623579

UnificationXref11559
type: UnificationXref
id: 5637572
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637572

SequenceSite3189
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11558
type: UnificationXref
id: 5637570
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637570

SequenceSite3188
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11557
type: UnificationXref
id: Q9U2M4
db: UniProt

UnificationXref11556
type: UnificationXref
id: REACT_26786
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26786.2

UnificationXref11555
type: UnificationXref
id: 880041
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880041

SequenceSite3185
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11554
type: UnificationXref
id: CHEBI:16724
db: ChEBI

SequenceSite3184
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11553
type: UnificationXref
id: REACT_24442
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24442.2

SequenceSite3187
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11552
type: UnificationXref
id: 880046
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880046

SequenceSite3186
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11551
type: UnificationXref
id: CHEBI:16265
db: ChEBI

SequenceSite3181
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref22616
type: UnificationXref
id: REACT_261167
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261167.1

UnificationXref11550
type: UnificationXref
id: REACT_25934
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25934.1

SequenceSite3180
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref22615
type: UnificationXref
id: 5623580
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623580

SequenceSite19331
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3183
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref22618
type: UnificationXref
id: REACT_231236
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231236.1

SequenceSite19330
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3182
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref22617
type: UnificationXref
id: 5652780
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652780

SequenceSite19333
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19332
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22619
type: UnificationXref
id: 5652603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652603

SequenceSite19335
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19334
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19329
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19327
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19328
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19325
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19326
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11549
type: UnificationXref
id: 880067
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880067

SequenceSite3148
type: SequenceSite
position status: EQUAL
sequence position: 209

SequenceSite3149
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11542
type: UnificationXref
id: 5637578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637578

SequenceSite3154
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11541
type: UnificationXref
id: 5637576
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637576

SequenceSite3153
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11544
type: UnificationXref
id: 5637580
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637580

SequenceSite3152
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11543
type: UnificationXref
id: REACT_224517
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224517.2

SequenceSite3151
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11546
type: UnificationXref
id: REACT_26586
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26586.1

SequenceSite3158
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11545
type: UnificationXref
id: 880069
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880069

SequenceSite3157
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11548
type: UnificationXref
id: 5637579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637579

SequenceSite3156
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11547
type: UnificationXref
id: 5637581
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637581

SequenceSite3155
type: SequenceSite
position status: EQUAL
sequence position: 52

SequenceSite19324
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19323
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19322
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19321
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19320
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite3150
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11540
type: UnificationXref
id: G5EE46
db: UniProt

SequenceSite19318
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19319
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19314
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19315
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19316
type: SequenceSite
position status: EQUAL
sequence position: 717

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

SequenceSite19317
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3159
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11538
type: UnificationXref
id: 879997
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879997

UnificationXref11539
type: UnificationXref
id: REACT_25542
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25542.2

UnificationXref11533
type: UnificationXref
id: REACT_26282
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26282.2

SequenceSite3163
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11532
type: UnificationXref
id: 880013
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880013

SequenceSite3162
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11531
type: UnificationXref
id: CHEBI:32797
db: ChEBI

SequenceSite3165
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11530
type: UnificationXref
id: REACT_232421
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_232421.1

SequenceSite3164
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11537
type: UnificationXref
id: REACT_221308
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221308.2

SequenceSite3167
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11536
type: UnificationXref
id: 5637588
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637588

SequenceSite3166
type: SequenceSite
position status: EQUAL
sequence position: 1103

UnificationXref11535
type: UnificationXref
id: 5637586
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5637586

SequenceSite3169
type: SequenceSite
position status: EQUAL
sequence position: 52

UnificationXref11534
type: UnificationXref
id: Q9N4Z0
db: UniProt

SequenceSite3168
type: SequenceSite
position status: EQUAL
sequence position: 1103

SequenceSite19311
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19310
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite19313
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19312
type: SequenceSite
position status: EQUAL
sequence position: 717

SequenceSite3161
type: SequenceSite
position status: EQUAL
sequence position: 52

SequenceSite3160
type: SequenceSite
position status: EQUAL
sequence position: 1103

SequenceSite3129
type: SequenceSite
position status: EQUAL
sequence position: 478

SequenceSite3128
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3127
type: SequenceSite
position status: EQUAL
sequence position: 478

SequenceSite3126
type: SequenceSite
position status: EQUAL
sequence position: 2

Potassium Channels
type: Pathway
data source: Provenance1
pathway component: REACT 234915.1
pathway component: REACT 212368.2
pathway component: REACT 254187.1
pathway component: Tandem pore domain potassium channels
evidence: Evidence2083
xref: UnificationXref15840
xref: UnificationXref15839
pathway order: PathwayStep2069
pathway order: PathwayStep2046
pathway order: PathwayStep2049
pathway order: PathwayStep2056
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

RelationshipXref2211
type: RelationshipXref
id: 5623605
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623605

UnificationXref22643
type: UnificationXref
id: 5652357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652357

RelationshipXref2210
type: RelationshipXref
id: GO:0000703
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22642
type: UnificationXref
id: 5652346
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652346

RelationshipXref2213
type: RelationshipXref
id: GO:0004520
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22641
type: UnificationXref
id: 5652345
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652345

RelationshipXref2212
type: RelationshipXref
id: GO:0006285
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22640
type: UnificationXref
id: 5652344
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652344

RelationshipXref2215
type: RelationshipXref
id: GO:0006284
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22647
type: UnificationXref
id: REACT_228484
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228484.1

RelationshipXref2214
type: RelationshipXref
id: 5623647
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623647

UnificationXref22646
type: UnificationXref
id: 5358526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5358526

RelationshipXref2217
type: RelationshipXref
id: 5623620
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623620

UnificationXref22645
type: UnificationXref
id: REACT_233503
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_233503.1

RelationshipXref2216
type: RelationshipXref
id: 5623618
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623618

UnificationXref22644
type: UnificationXref
id: 5652358
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652358

SequenceSite19385
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2218
type: RelationshipXref
id: 5623629
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623629

SequenceSite19386
type: SequenceSite
position status: EQUAL
sequence position: 1497

RelationshipXref2219
type: RelationshipXref
id: 5623631
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623631

SequenceSite19383
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref22648
type: UnificationXref
id: 5652364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652364

SequenceSite19384
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22649
type: UnificationXref
id: 5652366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652366

SequenceSite19389
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19387
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19388
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3135
type: SequenceSite
position status: EQUAL
sequence position: 478

SequenceSite3136
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3133
type: SequenceSite
position status: EQUAL
sequence position: 478

SequenceSite3134
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite19381
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3131
type: SequenceSite
position status: EQUAL
sequence position: 478

SequenceSite19382
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3132
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite19380
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite3130
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3138
type: SequenceSite
position status: EQUAL
sequence position: 350

RelationshipXref2220
type: RelationshipXref
id: GO:0003908
db: GENE ONTOLOGY
relationship type: MI:0355

ezetimibe
type: SmallMoleculeReference
name: ChEBI:49040 ezetimibe
xref: UnificationXref7841

SequenceSite3137
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref22650
type: UnificationXref
id: REACT_234148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234148.1

SequenceSite3139
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2224
type: RelationshipXref
id: GO:0046777
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22652
type: UnificationXref
id: 5652373
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652373

RelationshipXref2223
type: RelationshipXref
id: GO:0006281
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22651
type: UnificationXref
id: O62245
db: UniProt

RelationshipXref2222
type: RelationshipXref
id: GO:0006307
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22654
type: UnificationXref
id: 5652378
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652378

RelationshipXref2221
type: RelationshipXref
id: 5621919
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621919

UnificationXref22653
type: UnificationXref
id: 5652377
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652377

RelationshipXref2228
type: RelationshipXref
id: GO:0000715
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22656
type: UnificationXref
id: 5358610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5358610

RelationshipXref2227
type: RelationshipXref
id: GO:0006302
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22655
type: UnificationXref
id: REACT_229521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229521.1

RelationshipXref2226
type: RelationshipXref
id: GO:0000724
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22658
type: UnificationXref
id: 5652376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652376

RelationshipXref2225
type: RelationshipXref
id: GO:0000730
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22657
type: UnificationXref
id: REACT_228610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228610.1

SequenceSite19372
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11594
type: UnificationXref
id: REACT_245327
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245327.1

UnificationXref22659
type: UnificationXref
id: REACT_235384
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235384.1

SequenceSite19373
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11595
type: UnificationXref
id: 5652869
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652869

SequenceSite19374
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11592
type: UnificationXref
id: REACT_247058
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247058.1

RelationshipXref2229
type: RelationshipXref
id: 5621998
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5621998

SequenceSite19375
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11593
type: UnificationXref
id: 5652868
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652868

SequenceSite19376
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11590
type: UnificationXref
id: 5625109
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625109

SequenceSite19377
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11591
type: UnificationXref
id: 5625111
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625111

SequenceSite19378
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19379
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3144
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite3145
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3146
type: SequenceSite
position status: EQUAL
sequence position: 200

SequenceSite3147
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11598
type: UnificationXref
id: REACT_184602
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184602.3

SequenceSite3140
type: SequenceSite
position status: EQUAL
sequence position: 496

UnificationXref11599
type: UnificationXref
id: Q22134
db: UniProt

SequenceSite3141
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19370
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11596
type: UnificationXref
id: REACT_234962
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234962.1

SequenceSite3142
type: SequenceSite
position status: EQUAL
sequence position: 498

SequenceSite19371
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11597
type: UnificationXref
id: 5652511
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652511

SequenceSite3143
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/7970720
type: PublicationXref
id: 7970720
author: Daly, RJ
author: Sutherland, RL
author: deFazio, A
author: Janes, PW
db: Pubmed
title: Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
source: Oncogene 9:3601-8
year: 1994

SequenceSite3107
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3106
type: SequenceSite
position status: EQUAL
sequence position: 2273

SequenceSite3105
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3104
type: SequenceSite
position status: EQUAL
sequence position: 2215

SequenceSite3109
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3108
type: SequenceSite
position status: EQUAL
sequence position: 302

http://identifiers.org/pubmed/12118249
type: PublicationXref
id: 12118249
author: Kato, RM
author: Guo, B
author: Leitges, M
author: Kawakami, T
author: Humphries, LA
author: Patrone, L
author: Wall, R
author: Sommer, K
author: Kang, S
author: Kawakami, Y
author: Teitell, M
author: Su, TT
author: Chae, K
author: Rawlings, DJ
db: Pubmed
title: PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
source: Nat Immunol 3:780-6
year: 2002

UnificationXref22625
type: UnificationXref
id: Q9N3T8
db: UniProt

UnificationXref22624
type: UnificationXref
id: 5652350
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652350

UnificationXref22623
type: UnificationXref
id: Q9TXR4
db: UniProt

UnificationXref22622
type: UnificationXref
id: REACT_228358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228358.1

UnificationXref22621
type: UnificationXref
id: 5358514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5358514

UnificationXref22620
type: UnificationXref
id: REACT_256859
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_256859.1

SequenceSite19369
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19367
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19368
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19365
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19366
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11580
type: UnificationXref
id: 5625097
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625097

SequenceSite19363
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11581
type: UnificationXref
id: Q9TXI4
db: UniProt

UnificationXref22628
type: UnificationXref
id: 5652368
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652368

SequenceSite19364
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11582
type: UnificationXref
id: 5625101
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625101

UnificationXref22629
type: UnificationXref
id: 5652369
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652369

SequenceSite19361
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11583
type: UnificationXref
id: 159448
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159448

UnificationXref22626
type: UnificationXref
id: 5652354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652354

SequenceSite19362
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11584
type: UnificationXref
id: REACT_6438
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6438.3

UnificationXref22627
type: UnificationXref
id: 5652367
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652367

UnificationXref11585
type: UnificationXref
id: 5625102
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625102

SequenceSite19360
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11586
type: UnificationXref
id: 5625103
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625103

SequenceSite3110
type: SequenceSite
position status: EQUAL
sequence position: 1251

UnificationXref11587
type: UnificationXref
id: 5625105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625105

UnificationXref11588
type: UnificationXref
id: REACT_262134
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_262134.1

UnificationXref11589
type: UnificationXref
id: Q11190
db: UniProt

SequenceSite3113
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3114
type: SequenceSite
position status: EQUAL
sequence position: 1099

SequenceSite3111
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3112
type: SequenceSite
position status: EQUAL
sequence position: 690

SequenceSite3116
type: SequenceSite
position status: EQUAL
sequence position: 1099

SequenceSite3115
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3118
type: SequenceSite
position status: EQUAL
sequence position: 1099

SequenceSite3117
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3119
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2206
type: RelationshipXref
id: 5631958
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631958

UnificationXref22634
type: UnificationXref
id: REACT_236632
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_236632.1

RelationshipXref2205
type: RelationshipXref
id: GO:0006987
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22633
type: UnificationXref
id: 5652379
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652379

RelationshipXref2204
type: RelationshipXref
id: GO:0006626
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22636
type: UnificationXref
id: 5652338
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652338

RelationshipXref2203
type: RelationshipXref
id: 5640417
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640417

UnificationXref22635
type: UnificationXref
id: Q9XU10
db: UniProt

SequenceSite19359
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref2202
type: RelationshipXref
id: GO:0008320
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22630
type: UnificationXref
id: REACT_242993
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_242993.1

SequenceSite19358
type: SequenceSite
position status: EQUAL
sequence position: 1497

RelationshipXref2201
type: RelationshipXref
id: 5640495
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640495

RelationshipXref2200
type: RelationshipXref
id: 5640460
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5640460

UnificationXref22632
type: UnificationXref
id: 5652356
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652356

UnificationXref22631
type: UnificationXref
id: 5652355
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652355

http://identifiers.org/pubmed/2188967
type: PublicationXref
id: 2188967
author: Hackert, ML
author: Reed, LJ
db: Pubmed
title: Structure-function relationships in dihydrolipoamide acyltransferases.
source: J Biol Chem 265:8971-4
year: 1990

SequenceSite19354
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19355
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19356
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19357
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19350
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11572
type: UnificationXref
id: 5624683
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624683

RelationshipXref2209
type: RelationshipXref
id: GO:0045008
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22637
type: UnificationXref
id: Q9XXM5
db: UniProt

SequenceSite19351
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11573
type: UnificationXref
id: 5624684
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624684

UnificationXref22638
type: UnificationXref
id: 5652342
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652342

SequenceSite19352
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref11570
type: UnificationXref
id: 164934
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=164934

RelationshipXref2207
type: RelationshipXref
id: GO:0030968
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22639
type: UnificationXref
id: G5EFG5
db: UniProt

SequenceSite19353
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref11571
type: UnificationXref
id: REACT_6663
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6663.1

RelationshipXref2208
type: RelationshipXref
id: GO:0044267
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref11576
type: UnificationXref
id: REACT_2762
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2762.2

UnificationXref11577
type: UnificationXref
id: 5624686
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624686

UnificationXref11574
type: UnificationXref
id: CHEBI:17976
db: ChEBI

SequenceSite3120
type: SequenceSite
position status: EQUAL
sequence position: 350

UnificationXref11575
type: UnificationXref
id: 76633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76633

SequenceSite3121
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3122
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3123
type: SequenceSite
position status: EQUAL
sequence position: 350

UnificationXref11578
type: UnificationXref
id: REACT_257067
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_257067.1

SequenceSite3124
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref11579
type: UnificationXref
id: Q93615
db: UniProt

SequenceSite3125
type: SequenceSite
position status: EQUAL
sequence position: 386

http://identifiers.org/pubmed/1934265
type: PublicationXref
id: 1934265
author: Teitel, CH
author: Butler, MA
author: Kadlubar, FF
author: Turesky, RJ
author: Lang, NP
db: Pubmed
title: Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
source: Carcinogenesis 12:1839-45
year: 1991

Evidence1804
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16942634
xref: http://identifiers.org/pubmed/18155917
comment: Serotonin (5-HT) is a hormone and neurotransmitter used for regulatory purposes in animal CNS. In the human brain, serotonin is involved in many physiological functions such as sleep, pain, mood and is the precursor to melatonin, a hormone produced in the pineal gland.

UnificationXref22684
type: UnificationXref
id: 5622371
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622371

RelationshipXref2256
type: RelationshipXref
id: GO:0008286
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1805
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/3297964
xref: http://identifiers.org/pubmed/16942634
comment: Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan.

UnificationXref22685
type: UnificationXref
id: 5622372
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622372

RelationshipXref2257
type: RelationshipXref
id: 5629167
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5629167

Evidence1806
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16616139
xref: http://identifiers.org/pubmed/17088322
comment: Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).

UnificationXref22686
type: UnificationXref
id: 5622373
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622373

RelationshipXref2254
type: RelationshipXref
id: 5623443
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623443

Evidence1807
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12899834
xref: http://identifiers.org/pubmed/1703535
xref: http://identifiers.org/pubmed/2363689
xref: http://identifiers.org/pubmed/15802217
xref: http://identifiers.org/pubmed/3416563
comment: Alanine-glyoxylate transaminase (AGXT) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Danpure and Jennings 1988). The active form of the enzyme is a homodimer (Zhang et al. 2003) with one molecule of pyridoxal phosphate bound to each subunit (Coulter-Mackie et al. 2005). Mutations in this enzyme are associated with primary hyperoxaluria type I. Mutant alleles encode both catalytically inactive proteins and active ones that are mis-localized to mitochondria (Purdue et al. 1990; Takada et al. 1990).

UnificationXref22687
type: UnificationXref
id: 5622374
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622374

RelationshipXref2255
type: RelationshipXref
id: 5623491
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623491

Evidence1808
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2158891
xref: http://identifiers.org/pubmed/20018850
comment: Mitochondrial AGXT2 (alanine-glyoxylate transaminase 2) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Rodionov et al. 2010). The active form of the enzyme is inferred to be a homotetramer from the properties of the homologous rat protein, which has been purified and characterized in vitro (Tamaki et al.990). Most conversion of glyoxylate to glycine in vivo appears to occur in the peroxisome, catalyzed by AGXT, and the physiological role of the AGXT2 reaction is unclear.

UnificationXref22688
type: UnificationXref
id: 5622375
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622375

Evidence1809
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10524214
xref: http://identifiers.org/pubmed/10484776
comment: Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).

UnificationXref22689
type: UnificationXref
id: 5622376
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622376

RelationshipXref2258
type: RelationshipXref
id: GO:0043065
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2259
type: RelationshipXref
id: GO:0097190
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1800
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Thyroxine (T4) can be formed by the combination of two diiodotyrosines. The hormone thyrotropin can stimulate the production of T3 and T4.

UnificationXref22680
type: UnificationXref
id: 5622361
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622361

RelationshipXref2252
type: RelationshipXref
id: 5635911
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635911

Evidence1801
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3297964
comment: Thyroxine (3,5,3',5'-tetraiodothyronine, T4) promotes normal growth and development. It also regulates heat and energy production. T4 is released from the thyroid gland, the largest endocrine organ in the human body. The primary hormone released is T4 although T3 (3,5,3'-triiodothyronine) is also released in small quantities. Tyrosine residues in thyroglobulin (a glycoprotein scaffold containing many tyrosine residues) are iodinated to form mono- or diiodo-tyrosine which can then couple to form either T3 or T4.

UnificationXref22681
type: UnificationXref
id: 5622364
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622364

RelationshipXref2253
type: RelationshipXref
id: GO:0007050
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1802
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12511643
xref: http://identifiers.org/pubmed/12379098
xref: http://identifiers.org/pubmed/10872454
comment: The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

UnificationXref22682
type: UnificationXref
id: 5622367
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622367

RelationshipXref2250
type: RelationshipXref
id: 5628261
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628261

Evidence1803
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1540578
xref: http://identifiers.org/pubmed/2590185
comment: Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both dopa and 5-hydroxytryptophan to dopamine and serotonin, respectively. AADC functions as a homodimer, utilizing pyridoxal phosphate as a cofactor.

UnificationXref22683
type: UnificationXref
id: 5622370
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622370

RelationshipXref2251
type: RelationshipXref
id: 5631948
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5631948

SequenceSite3103
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3102
type: SequenceSite
position status: EQUAL
sequence position: 533

SequenceSite3101
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite3100
type: SequenceSite
position status: EQUAL
sequence position: 112

UnificationXref22697
type: UnificationXref
id: 5622384
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622384

RelationshipXref2265
type: RelationshipXref
id: GO:0001609
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22698
type: UnificationXref
id: REACT_204201
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_204201.2

RelationshipXref2266
type: RelationshipXref
id: 5626300
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626300

UnificationXref22695
type: UnificationXref
id: 5622382
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622382

RelationshipXref2267
type: RelationshipXref
id: GO:0007190
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22696
type: UnificationXref
id: 5622383
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622383

RelationshipXref2268
type: RelationshipXref
id: GO:0007169
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2269
type: RelationshipXref
id: GO:0008321
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22699
type: UnificationXref
id: 5623472
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623472

UnificationXref22690
type: UnificationXref
id: 5622377
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622377

RelationshipXref2260
type: RelationshipXref
id: GO:0005089
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref22693
type: UnificationXref
id: 5622380
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622380

RelationshipXref2261
type: RelationshipXref
id: 5626961
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5626961

UnificationXref22694
type: UnificationXref
id: 5622381
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622381

RelationshipXref2262
type: RelationshipXref
id: GO:0050771
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22691
type: UnificationXref
id: 5622378
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622378

RelationshipXref2263
type: RelationshipXref
id: GO:0050770
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22692
type: UnificationXref
id: 5622379
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622379

RelationshipXref2264
type: RelationshipXref
id: GO:0048011
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2238
type: RelationshipXref
id: GO:0006283
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22666
type: UnificationXref
id: 5358521
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5358521

RelationshipXref2239
type: RelationshipXref
id: GO:0006289
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22667
type: UnificationXref
id: REACT_228934
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228934.1

RelationshipXref2236
type: RelationshipXref
id: GO:0000716
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22668
type: UnificationXref
id: 5652361
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652361

RelationshipXref2237
type: RelationshipXref
id: 5623575
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623575

UnificationXref22669
type: UnificationXref
id: 5652363
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652363

Evidence1826
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12832624
xref: http://identifiers.org/pubmed/18494801
comment: When SQR is in the oxidized state, it can bind hydrogen sulfide as persulfide to one of its own cysteine residue, the electrons being transferred to ubiquinone. After that the additional sulfur is dioxygenated by another enzyme (ETHE1). The activity of human SQR was deduced from the orthologue in Arenicola marina (Theissen et al. 2003, Hildebrandt & Grieshaber 2008).

RelationshipXref2234
type: RelationshipXref
id: GO:0000718
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22662
type: UnificationXref
id: 5358527
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5358527

Evidence1827
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19136963
comment: The sulfur dioxygenase ETHE1 converts persulfides to sulfite. Loss of this activity leads to the rare ethylmalonyl encephalopathy where the body can no longer detoxify H2S (Tiranti et al, 2009).

RelationshipXref2235
type: RelationshipXref
id: GO:0006297
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22663
type: UnificationXref
id: REACT_229232
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229232.1

Evidence1828
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18494801
comment: The main reaction catalyzed by rhodanase is not the name-giving detoxification of cyanide to thiocyanate, but the transfer of a sulfur atom from SQR-S-SH onto sulfite yielding thiosulfate during sulfide oxidation. The activity of human rhodanase was inferred from the rat orthologue by Hildebrandt & Grieshaber, 2008.

RelationshipXref2232
type: RelationshipXref
id: 5622011
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5622011

UnificationXref22664
type: UnificationXref
id: 5652359
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652359

Evidence1829
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17459792
xref: http://identifiers.org/pubmed/16475804
comment: Sulfite oxidase oxidizes sulfite to sulfate which is among the most important macronutrients in cells and the fourth most abundant anion in human plasma (300 micromolar). The enzyme has a molybdenum-molybdopterin cofactor (MoCo) bound (Wilson et al. 2006, Feng et al. 2007).

RelationshipXref2233
type: RelationshipXref
id: GO:0006295
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref22665
type: UnificationXref
id: 5652360
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652360

Evidence1822
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17135237
comment: Oxidation of the thiol moiety of cysteine yields sulfinoalanine, which itself is processed to hypotaurine by an as of yet uncharacterized enzyme in humans . Whether further oxidation of hypotaurine to taurine needs an enzyme is unknown at present (Ye et al. 2007).

RelationshipXref2230
type: RelationshipXref
id: GO:0000717
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1823
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/236774
comment: Cysteine sulfinic acid decarboxylase (CSAD) mediates the decarboxylase of 3-sulfinoalanine to produce hypotuarine. CSAD functions as a homodimer and requires pyridoxal phosphate as a cofactor. Purification, characterisation and activity of CSAD has been determined from rat liver (Guion-Rain et al. 1975).

RelationshipXref2231
type: RelationshipXref
id: GO:0006293
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1824
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

UnificationXref22660
type: UnificationXref
id: 5653555
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653555

Evidence1825
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

UnificationXref22661
type: UnificationXref
id: REACT_243976
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_243976.1

Evidence1820
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Evidence1821
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

SequenceSite19393
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19392
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19391
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/19513348
type: PublicationXref
id: 19513348
author: Szczepanowska, J
db: Pubmed
title: Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements
source: Acta Biochim Pol 56:225-34
year: 2009

SequenceSite19390
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19399
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19398
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19397
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19396
type: SequenceSite
position status: EQUAL
sequence position: 1497

SequenceSite19395
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19394
type: SequenceSite
position status: EQUAL
sequence position: 1497

UnificationXref22679
type: UnificationXref
id: REACT_240885
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_240885.1

RelationshipXref2247
type: RelationshipXref
id: 5624637
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624637

RelationshipXref2248
type: RelationshipXref
id: 5624903
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624903

Evidence1819
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12473676
comment: A cytosolic, non-specific peptidase can hydrolyze cysteinylglycine to release cysteine and glycine (Tuefel et al, 2003).

UnificationXref22677
type: UnificationXref
id: REACT_253210
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253210.1

RelationshipXref2249
type: RelationshipXref
id: 5624922
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624922

UnificationXref22678
type: UnificationXref
id: 5652598
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652598

Evidence1817
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20817827
xref: http://identifiers.org/pubmed/15497768
comment: Transsulfuration is the interconversion of homocysteine and cysteine, and it fully takes place in bacteria and some plants and fungi. Animals however have only one direction of this bidirectional path, the synthesis of cysteine from homocysteine via cystathionine. Because excess cysteine is degraded to hydrogen sulfide, which is now known as a neuromodulator and smooth muscle relaxant, this pathway is also the main source of its production, which takes place in the cytosol, as well as in extracellular space (Dominy & Stipanuk 2004, Bearden et al. 2010).

UnificationXref22675
type: UnificationXref
id: REACT_247610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247610.1

RelationshipXref2243
type: RelationshipXref
id: 5623471
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623471

Evidence1818
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7826375
xref: http://identifiers.org/pubmed/9675072
comment: The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalyzed by the dimeric protein glutamate-cysteine ligase (Gipp et al, 1995; Misra and Griffith, 1998).

UnificationXref22676
type: UnificationXref
id: 5653556
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653556

RelationshipXref2244
type: RelationshipXref
id: 5623419
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5623419

Evidence1815
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11524006
comment: The first step of homocysteine conversion to cysteine is catalyzed by cystathionine beta-lyase, which adds a serine molecule to the substrate. The enzyme is a tetramer with two heme molecules as cofactor (Janosik et al. 2001).

UnificationXref22673
type: UnificationXref
id: REACT_231184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231184.1

RelationshipXref2245
type: RelationshipXref
id: 5624635
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5624635

Evidence1816
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999).

UnificationXref22674
type: UnificationXref
id: 5653557
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5653557

RelationshipXref2246
type: RelationshipXref
id: GO:0004114
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence1813
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12163696
xref: http://identifiers.org/pubmed/9175157
comment: S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is a precursor in the synthesis of polyamines. Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). A third gene MAT2B has been identified and is known to be a part of MAT II heterotetramer complex.

UnificationXref22671
type: UnificationXref
id: 5652374
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652374

Evidence1814
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'S-adenosylhomocysteine', and 1 molecule of 'H2O' are present. At the end of this reaction, 1 molecule of 'adenosine', and 1 molecule of 'Homocysteine' are present. This reaction takes place in the 'cytosol' and is mediated by the 'adenosylhomocysteinase activity' of 'SAH hydrolase homotetramer'.

RelationshipXref2240
type: RelationshipXref
id: 5652365
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652365

UnificationXref22672
type: UnificationXref
id: 5652375
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652375

Evidence1811
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10978532
xref: http://identifiers.org/pubmed/18215067
xref: http://identifiers.org/pubmed/17669354
xref: http://identifiers.org/pubmed/10777549
comment: Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glyoxylate to form oxalate. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

RelationshipXref2241
type: RelationshipXref
id: GO:0006298
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence1812
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15956068
comment: Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate (Danpure 2005). The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified.

RelationshipXref2242
type: RelationshipXref
id: 5652362
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652362

UnificationXref22670
type: UnificationXref
id: REACT_230834
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230834.1

Evidence1810
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10978532
xref: http://identifiers.org/pubmed/18215067
xref: http://identifiers.org/pubmed/17669354
xref: http://identifiers.org/pubmed/10777549
comment: Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glycolate and O2 to form glyoxylate and H2O2. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

RelationshipXref412
type: RelationshipXref
id: GO:0008466
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref413
type: RelationshipXref
id: 5650442
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650442

RelationshipXref414
type: RelationshipXref
id: 5650401
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650401

RelationshipXref415
type: RelationshipXref
id: 5650432
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650432

RelationshipXref410
type: RelationshipXref
id: GO:0003983
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref411
type: RelationshipXref
id: 5619290
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619290

UnificationXref11525
type: UnificationXref
id: 5636266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5636266

UnificationXref11526
type: UnificationXref
id: REACT_193765
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_193765.3

UnificationXref11523
type: UnificationXref
id: 5619887
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619887

UnificationXref11524
type: UnificationXref
id: REACT_260289
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260289.1

UnificationXref11521
type: UnificationXref
id: 5619884
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619884

UnificationXref11522
type: UnificationXref
id: 5619885
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619885

UnificationXref11520
type: UnificationXref
id: O17214
db: UniProt

RelationshipXref2293
type: RelationshipXref
id: 5652321
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652321

RelationshipXref2292
type: RelationshipXref
id: 5652064
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652064

RelationshipXref2291
type: RelationshipXref
id: 5628054
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628054

RelationshipXref2290
type: RelationshipXref
id: 5628018
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5628018

RelationshipXref2297
type: RelationshipXref
id: 5652068
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652068

UnificationXref11529
type: UnificationXref
id: 5652526
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652526

RelationshipXref2296
type: RelationshipXref
id: 5652104
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652104

UnificationXref11528
type: UnificationXref
id: REACT_231548
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231548.1

RelationshipXref2295
type: RelationshipXref
id: 5645627
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5645627

UnificationXref11527
type: UnificationXref
id: 5619880
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619880

RelationshipXref2294
type: RelationshipXref
id: 5652332
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652332

RelationshipXref2299
type: RelationshipXref
id: 5652079
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652079

RelationshipXref2298
type: RelationshipXref
id: 5652041
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5652041

RelationshipXref417
type: RelationshipXref
id: GO:0004373
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref416
type: RelationshipXref
id: 5650439
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650439

RelationshipXref419
type: RelationshipXref
id: 5650445
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650445

RelationshipXref418
type: RelationshipXref
id: 5650395
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650395

RelationshipXref425
type: RelationshipXref
id: 5650805
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650805

RelationshipXref426
type: RelationshipXref
id: GO:0019203
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref423
type: RelationshipXref
id: GO:0061547
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref424
type: RelationshipXref
id: 5650830
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650830

RelationshipXref421
type: RelationshipXref
id: GO:0003844
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref422
type: RelationshipXref
id: 5650411
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650411

RelationshipXref420
type: RelationshipXref
id: 5650429
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650429

UnificationXref11512
type: UnificationXref
id: 113591
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113591

UnificationXref11513
type: UnificationXref
id: REACT_4380
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4380.1

UnificationXref11514
type: UnificationXref
id: 5619902
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619902

Toll-Like Receptors Cascades
type: Pathway
data source: Provenance1
pathway component: REACT 261637.1
pathway component: REACT 260673.1
pathway component: REACT 240159.1
pathway component: REACT 251476.1
pathway component: REACT 245780.1
pathway component: REACT 247327.1
pathway component: REACT 240910.1
evidence: Evidence3318
xref: UnificationXref25585
xref: UnificationXref25586
xref: RelationshipXref2415
pathway order: PathwayStep3279
pathway order: PathwayStep3278
pathway order: PathwayStep3269
pathway order: PathwayStep3283
pathway order: PathwayStep3273
pathway order: PathwayStep3274
pathway order: PathwayStep3286
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/6239

UnificationXref11515
type: UnificationXref
id: P41956
db: UniProt

UnificationXref11510
type: UnificationXref
id: Q09545
db: UniProt

UnificationXref11511
type: UnificationXref
id: 5619901
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619901

UnificationXref11517
type: UnificationXref
id: 5619911
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619911

UnificationXref11516
type: UnificationXref
id: 5619906
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619906

UnificationXref11519
type: UnificationXref
id: REACT_258868
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_258868.1

UnificationXref11518
type: UnificationXref
id: 5619913
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619913

RelationshipXref429
type: RelationshipXref
id: GO:0005978
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/16087667
type: PublicationXref
id: 16087667
author: Harris, CL
author: Neal, Jim W
author: Mizuno, Masashi
author: Griffiths, Mark
author: Gasque, Philippe
author: Elward, Kristina
author: Morgan, B Paul
db: Pubmed
title: CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells
source: J. Biol. Chem. 280:36342-54
year: 2005

RelationshipXref428
type: RelationshipXref
id: 5650811
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650811

RelationshipXref427
type: RelationshipXref
id: 5650825
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5650825

UnificationXref11500
type: UnificationXref
id: 113588
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113588

UnificationXref11503
type: UnificationXref
id: 5619891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619891

UnificationXref11504
type: UnificationXref
id: Q09508
db: UniProt

http://identifiers.org/pubmed/10567352
type: PublicationXref
id: 10567352
author: Painter, GF
author: Cooke, FT
author: Holmes, AB
author: McEwen, RK
author: Ohya, Y
author: Shisheva, A
author: Michell, RH
author: Parker, PJ
author: Dove, SK
db: Pubmed
title: Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
source: J Biol Chem 274:33905-12
year: 1999

UnificationXref11501
type: UnificationXref
id: REACT_5289
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5289.2

UnificationXref11502
type: UnificationXref
id: O44954
db: UniProt

UnificationXref11508
type: UnificationXref
id: O62215
db: UniProt

RelationshipXref2275
type: RelationshipXref
id: 5625208
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625208

UnificationXref11507
type: UnificationXref
id: 5619897
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619897

RelationshipXref2274
type: RelationshipXref
id: 5625374
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625374

UnificationXref11506
type: UnificationXref
id: 5619896
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619896

RelationshipXref2273
type: RelationshipXref
id: 5625397
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625397

UnificationXref11505
type: UnificationXref
id: 5619895
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619895

RelationshipXref2272
type: RelationshipXref
id: GO:0007264
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/3053703
type: PublicationXref
id: 3053703
author: Meister, A
db: Pubmed
title: Glutathione metabolism and its selective modification
source: J Biol Chem 263:17205-8
year: 1988

RelationshipXref2271
type: RelationshipXref
id: GO:0007265
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2270
type: RelationshipXref
id: 5625447
db: Reactome Database ID Release 49
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5625447

http://identifiers.org/pubmed/3053705
type: PublicationXref
id: 3053705
author: Sample, C
author: Bell, GI
author: Sanke, T
author: Rubenstein, AH
author: Steiner, DF
db: Pubmed
title: An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing
source: J Biol Chem 263:17243-6
year: 1988

UnificationXref11509
type: UnificationXref
id: 5619910
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5619910