Arenicola marina
type: BioSource
xref: UnificationXref12

Catalysis1
type: Catalysis
data source: Reactome
controlled: Sqr oxidizes sulfide to bound persulfide
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: Sqr:FAD

Stoichiometry7
type: Stoichiometry
physical entity: Flavin adenine dinucleotide
stoichiometric coefficient: 1.0

Stoichiometry6
type: Stoichiometry
physical entity: Sqr-S-SH
stoichiometric coefficient: 2.0

Stoichiometry8
type: Stoichiometry
physical entity: Sqr(ox.)
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: H2S
stoichiometric coefficient: 2.0

Stoichiometry2
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 4.0

FAD [ChEBI:16238]
type: SmallMoleculeReference
name: FAD
name: Flavin adenine dinucleotide
xref: UnificationXref23

Stoichiometry5
type: Stoichiometry
physical entity: Coenzyme QH2
stoichiometric coefficient: 2.0

Stoichiometry4
type: Stoichiometry
physical entity: Sqr(ox.)
stoichiometric coefficient: 2.0

mitochondrial inner membrane
type: CellularLocationVocabulary
xref: UnificationXref1

L-cysteine persulfide
type: SequenceModificationVocabulary
xref: UnificationXref20

UnificationXref30
type: UnificationXref
id: REACT_200669
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_200669.1

Stoichiometry1
type: Stoichiometry
physical entity: Coenzyme Q
stoichiometric coefficient: 2.0

UnificationXref13
type: UnificationXref
id: B0LD08
db: UniProt

Sqr-S-SH
type: Protein
entity reference: SQR
data source: Reactome
xref: UnificationXref22
xref: UnificationXref21
feature: ModificationFeature3
feature: FragmentFeature2
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 1614658

UnificationXref12
type: UnificationXref
id: 6344
db: NCBI Taxonomy

UnificationXref11
type: UnificationXref
id: REACT_116358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116358.1

Sqr(ox.)
type: Protein
entity reference: SQR
data source: Reactome
xref: UnificationXref16
xref: UnificationXref15
feature: ModificationFeature1
feature: ModificationFeature2
feature: FragmentFeature1
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 1614620

UnificationXref10
type: UnificationXref
id: 1614532
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614532

UnificationXref17
type: UnificationXref
id: CHEBI:17976
db: ChEBI

UnificationXref16
type: UnificationXref
id: REACT_201712
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201712.1

UnificationXref15
type: UnificationXref
id: 1614620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614620

UnificationXref14
type: UnificationXref
id: MOD:00798
db: MOD

H+
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref7
xref: UnificationXref6
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 1614597

SQR
type: ProteinReference
name: UniProt:B0LD08
xref: UnificationXref13
organism: Arenicola marina

H2S
type: SmallMolecule
entity reference: Hydrogen sulfide [ChEBI:5787]
data source: Reactome
xref: UnificationXref11
xref: UnificationXref10
cellular location: cytosol
comment: Reactome DB_ID: 1614532

Coenzyme QH2
type: SmallMolecule
entity reference: Coenzyme QH2
data source: Reactome
name: CoQH2
name: ubiquinol
xref: UnificationXref19
xref: UnificationXref18
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 76633
display name: QH2

UnificationXref19
type: UnificationXref
id: REACT_2762
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2762.2

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: FAD [ChEBI:16238]
data source: Reactome
xref: UnificationXref24
xref: UnificationXref25
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 113597
display name: FAD

UnificationXref18
type: UnificationXref
id: 76633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76633

Sqr oxidizes sulfide to bound persulfide
type: BiochemicalReaction
data source: Reactome
conversion direction: LEFT_TO_RIGHT
xref: http://identifiers.org/pubmed/18248458
xref: UnificationXref29
xref: UnificationXref30
participant stoichiometry: Stoichiometry6
participant stoichiometry: Stoichiometry3
participant stoichiometry: Stoichiometry2
participant stoichiometry: Stoichiometry5
participant stoichiometry: Stoichiometry4
participant stoichiometry: Stoichiometry1
left: Sqr(ox.)
left: H+
left: H2S
left: Coenzyme Q
comment: When Sqr is in the oxidized state, it can bind hydrogen sulfide as persulfide to one of its own cysteine residue, the electrons being transferred to ubiquinone. After that, the additional sulfur is dioxygenated by another enzyme (SDO). (Theissen & Martin, 2008).
comment: Authored: Stephan, R, 2010-10-24
right: Sqr-S-SH
right: Coenzyme QH2

Coenzyme Q
type: SmallMolecule
entity reference: CoQ
data source: Reactome
name: CoQ
name: ubiquinone
xref: UnificationXref4
xref: UnificationXref3
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 73663
display name: Q

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref28

http://identifiers.org/pubmed/18248458
type: PublicationXref
id: 18248458
author: Theissen, U
author: Martin, W
db: Pubmed
title: Sulfide : quinone oxidoreductase (SQR) from the lugworm Arenicola marina shows cyanide- and thioredoxin-dependent activity
source: FEBS J 275:1131-9
year: 2008

Reactome
type: Provenance
comment: http://www.reactome.org

CoQ
type: SmallMoleculeReference
name: Coenzyme Q
name: Q
name: Ubiquinone
name: Ubiquinone [ChEBI:16389]
xref: UnificationXref2

Sqr:FAD
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry7
component stoichiometry: Stoichiometry8
component: Sqr(ox.)
component: Flavin adenine dinucleotide
xref: UnificationXref26
xref: UnificationXref27
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 1614552

UnificationXref20
type: UnificationXref
id: MOD:00274
db: MOD

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref5

UnificationXref22
type: UnificationXref
id: REACT_201811
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201811.1

UnificationXref21
type: UnificationXref
id: 1614658
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614658

UnificationXref24
type: UnificationXref
id: 113597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113597

UnificationXref23
type: UnificationXref
id: CHEBI:16238
db: ChEBI

UnificationXref26
type: UnificationXref
id: 1614552
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614552

UnificationXref25
type: UnificationXref
id: REACT_3156
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3156.1

UnificationXref28
type: UnificationXref
id: MI:0355
db: MI

UnificationXref27
type: UnificationXref
id: REACT_201510
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_201510.1

UnificationXref29
type: UnificationXref
id: 1614571
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614571

Same Catalyst Activity
type: RelationshipTypeVocabulary

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 458

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 208

RelationshipXref2
type: RelationshipXref
id: 1614520
db: Reactome Database ID Release 49
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614520

cytosol
type: CellularLocationVocabulary
xref: UnificationXref8

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 356

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 208

Coenzyme QH2
type: SmallMoleculeReference
name: QH2
name: CoQH2
name: ubiquinol
name: ubiquinol [ChEBI:17976]
xref: UnificationXref17

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref14

RelationshipXref1
type: RelationshipXref
id: GO:0070224
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref8
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref7
type: UnificationXref
id: REACT_117647
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117647.1

UnificationXref6
type: UnificationXref
id: 1614597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614597

UnificationXref5
type: UnificationXref
id: CHEBI:15378
db: ChEBI

UnificationXref4
type: UnificationXref
id: REACT_4901
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4901.2

UnificationXref3
type: UnificationXref
id: 73663
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73663

UnificationXref2
type: UnificationXref
id: CHEBI:16389
db: ChEBI

UnificationXref1
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Hydrogen sulfide [ChEBI:5787]
type: SmallMoleculeReference
name: H2S
name: Hydrogen-sulfide
name: Hydrogen sulfide
xref: UnificationXref9

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 458

UnificationXref9
type: UnificationXref
id: CHEBI:16136
db: ChEBI