UniProt:F4JMI5
type: ProteinReference
xref: UnificationXref11061
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/11903050
type: PublicationXref
id: 11903050
author: MacMullen, CM
author: Smith, TJ
author: Poncz, M
author: Hsu, BY
author: Fang, J
author: Stanley, CA
db: Pubmed
title: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
source: Biochem J 363:81-7
year: 2002

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

http://identifiers.org/pubmed/8774846
type: PublicationXref
id: 8774846
author: Cohen, P
author: Young, P R
author: Clifton, A D
db: Pubmed
title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
source: FEBS Lett. 392:209-14
year: 1996

http://identifiers.org/pubmed/8662638
type: PublicationXref
id: 8662638
author: Wilson, MP
author: Majerus, PW
db: Pubmed
title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
source: J Biol Chem 271:11904-10
year: 1996

UniProt:P18616
type: ProteinReference
xref: UnificationXref5943
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

http://identifiers.org/pubmed/17322878
type: PublicationXref
id: 17322878
author: Citri, A
author: Yarden, Y
author: Amit, I
author: Jacob-Hirsch, J
author: Siwak, D
author: Segal, E
author: Lu, Y
author: Tarcic, G
author: Amariglio, N
author: Mills, GB
author: Katz, M
author: Shay, T
author: Vaisman, N
author: Lahad, J
author: Domany, E
author: Rechavi, G
author: Alon, U
author: Zhang, F
db: Pubmed
title: A module of negative feedback regulators defines growth factor signaling
source: Nat Genet 39:503-12
year: 2007

PLC-mediated hydrolysis of PIP2
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction32
evidence: Evidence55
xref: UnificationXref1681
xref: UnificationXref1680
pathway order: PathwayStep50
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

Miscellaneous substrates
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1168
pathway component: BiochemicalReaction1167
evidence: Evidence1724
xref: UnificationXref17877
xref: UnificationXref17878
pathway order: PathwayStep1697
pathway order: PathwayStep1696
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UniProt:F4JML5
type: ProteinReference
xref: UnificationXref16762
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

IRS-related events triggered by IGF1R
type: Pathway
data source: Provenance1
pathway component: REACT 231305.1
evidence: Evidence2011
xref: UnificationXref19961
xref: UnificationXref19962
pathway order: PathwayStep1918
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/7356336
type: PublicationXref
id: 7356336
author: Logue, EA
author: Fall, RR
author: Hector, ML
author: Cochran, BC
db: Pubmed
title: Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
source: Arch Biochem Biophys 199:28-36
year: 1980

UniProt:Q9ZNV4
type: ProteinReference
xref: UnificationXref11376
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

Interferon Signaling
type: Pathway
data source: Provenance1
pathway component: REACT 259223.1
evidence: Evidence1925
xref: UnificationXref19434
xref: UnificationXref19435
xref: RelationshipXref1644
pathway order: PathwayStep1893
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UniProt:Q9ZNW0
type: ProteinReference
xref: UnificationXref11838
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/8631325
type: PublicationXref
id: 8631325
author: Peng, HL
author: Chao, YC
author: Chang, HY
author: Duggleby, RG
author: Huang, JG
db: Pubmed
title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
source: Eur J Biochem 235:173-9
year: 1996

UniProt:F4JMJ1
type: ProteinReference
xref: UnificationXref21363
organism: http://identifiers.org/taxonomy/3702

UnificationXref18325
type: UnificationXref
id: 6253571
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253571

UnificationXref18326
type: UnificationXref
id: Q56Z58
db: UniProt

UnificationXref18327
type: UnificationXref
id: 6253573
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253573

UnificationXref18328
type: UnificationXref
id: 6253574
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253574

UnificationXref18321
type: UnificationXref
id: CHEBI:78575
db: ChEBI

UnificationXref18322
type: UnificationXref
id: 5423729
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5423729

UnificationXref18323
type: UnificationXref
id: REACT_229295
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229295.1

UnificationXref18324
type: UnificationXref
id: Q8VZ23
db: UniProt

UnificationXref18320
type: UnificationXref
id: REACT_228863
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_228863.1

UniProt:Q9ZNT1
type: ProteinReference
xref: UnificationXref11397
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

UnificationXref18319
type: UnificationXref
id: 5423727
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5423727

UnificationXref18318
type: UnificationXref
id: CHEBI:53107
db: ChEBI

UnificationXref18338
type: UnificationXref
id: REACT_241431
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241431.1

UnificationXref18339
type: UnificationXref
id: 6253661
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253661

UnificationXref18336
type: UnificationXref
id: REACT_259671
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259671.1

UnificationXref18337
type: UnificationXref
id: 6253950
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253950

UnificationXref18334
type: UnificationXref
id: 6253580
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253580

UnificationXref18335
type: UnificationXref
id: 6253582
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253582

UnificationXref18332
type: UnificationXref
id: 6253578
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253578

UnificationXref18333
type: UnificationXref
id: 6253579
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253579

UnificationXref18330
type: UnificationXref
id: 6253576
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253576

UnificationXref18331
type: UnificationXref
id: 6253577
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253577

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

UnificationXref18329
type: UnificationXref
id: 6253575
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253575

UnificationXref18343
type: UnificationXref
id: O64731
db: UniProt

UnificationXref18344
type: UnificationXref
id: 6248438
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248438

UnificationXref18345
type: UnificationXref
id: Q8L6Z2
db: UniProt

UnificationXref18346
type: UnificationXref
id: 6248442
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248442

UnificationXref18347
type: UnificationXref
id: Q9LMJ6
db: UniProt

UnificationXref18348
type: UnificationXref
id: 6248444
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248444

UnificationXref18349
type: UnificationXref
id: Q8LEH2
db: UniProt

UnificationXref18340
type: UnificationXref
id: REACT_251506
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_251506.1

UnificationXref18341
type: UnificationXref
id: 1362385
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1362385

UnificationXref18342
type: UnificationXref
id: REACT_151452
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151452.1

UnificationXref18356
type: UnificationXref
id: 6248452
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248452

UnificationXref18357
type: UnificationXref
id: 6248453
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248453

UnificationXref18354
type: UnificationXref
id: 6248450
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248450

UnificationXref18355
type: UnificationXref
id: 6248451
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248451

UnificationXref18358
type: UnificationXref
id: 6248455
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248455

UnificationXref18359
type: UnificationXref
id: REACT_184311
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184311.3

UniProt:Q9ZNS0
type: ProteinReference
xref: UnificationXref8889
organism: http://identifiers.org/taxonomy/3702

UnificationXref18352
type: UnificationXref
id: 6248448
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248448

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

UnificationXref18353
type: UnificationXref
id: 6248449
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248449

UnificationXref18350
type: UnificationXref
id: 6248446
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248446

UnificationXref18351
type: UnificationXref
id: 6248447
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248447

UnificationXref18362
type: UnificationXref
id: O49627
db: UniProt

UnificationXref18361
type: UnificationXref
id: 6248395
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248395

UnificationXref18364
type: UnificationXref
id: O81433
db: UniProt

UnificationXref18363
type: UnificationXref
id: 6248399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248399

http://identifiers.org/pubmed/12700044
type: PublicationXref
id: 12700044
author: Maness, PF
author: Thelen, K
author: Panicker, AK
author: Buhusi, M
db: Pubmed
title: Cellular signalling mechanisms of neural cell adhesion molecules
source: Front Biosci 8:d900-11
year: 2003

UnificationXref18360
type: UnificationXref
id: Q9MAB6
db: UniProt

UnificationXref18369
type: UnificationXref
id: Q9ZR07
db: UniProt

UnificationXref18366
type: UnificationXref
id: 6248404
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248404

UnificationXref18365
type: UnificationXref
id: 6248403
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248403

UnificationXref18368
type: UnificationXref
id: 6248408
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248408

UnificationXref18367
type: UnificationXref
id: Q8L9E3
db: UniProt

UniProt:F4JME7
type: ProteinReference
xref: UnificationXref5813
organism: http://identifiers.org/taxonomy/3702

UnificationXref18375
type: UnificationXref
id: 6248433
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248433

UnificationXref18374
type: UnificationXref
id: 6248412
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248412

UnificationXref18373
type: UnificationXref
id: 6248411
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248411

UnificationXref18372
type: UnificationXref
id: REACT_4019
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4019.2

UnificationXref18371
type: UnificationXref
id: 113583
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113583

UnificationXref18370
type: UnificationXref
id: 6248409
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248409

UnificationXref18379
type: UnificationXref
id: REACT_184234
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184234.3

UnificationXref18378
type: UnificationXref
id: 6248434
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248434

UnificationXref18377
type: UnificationXref
id: 6248413
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248413

UnificationXref18376
type: UnificationXref
id: 6248410
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248410

http://identifiers.org/pubmed/15538381
type: PublicationXref
id: 15538381
author: Lu, M
author: Gherzi, R
author: Leuenberger, SA
author: Hemmings, BA
author: Stoecklin, G
author: Hess, D
author: Mallaun, M
author: Schmidlin, M
author: Moroni, C
author: Gross, B
db: Pubmed
title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
source: EMBO J 23:4760-9
year: 2004

UnificationXref18380
type: UnificationXref
id: Q93ZJ7
db: UniProt

UnificationXref18382
type: UnificationXref
id: Q8W3L1
db: UniProt

UnificationXref18381
type: UnificationXref
id: 6251753
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251753

UnificationXref18384
type: UnificationXref
id: 6251756
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251756

UnificationXref18383
type: UnificationXref
id: 6251755
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251755

UnificationXref18386
type: UnificationXref
id: 6251757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251757

UnificationXref18385
type: UnificationXref
id: 6251758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251758

UnificationXref18388
type: UnificationXref
id: REACT_176020
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176020.3

UnificationXref18387
type: UnificationXref
id: 6251760
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251760

UnificationXref18389
type: UnificationXref
id: CHEBI:33737
db: ChEBI

http://identifiers.org/pubmed/7635144
type: PublicationXref
id: 7635144
author: Squire, JA
author: Reck, F
author: Bendiak, B
author: Leong, P
author: Tan, J
author: D'Agostaro, AF
author: Schachter, H
author: Sarkar, M
db: Pubmed
title: The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein
source: Eur J Biochem 231:317-28
year: 1995

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

UnificationXref18393
type: UnificationXref
id: 6248417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248417

UnificationXref18392
type: UnificationXref
id: Q8LDZ8
db: UniProt

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

UnificationXref18391
type: UnificationXref
id: REACT_152181
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152181.1

UnificationXref18390
type: UnificationXref
id: 2395501
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2395501

UnificationXref18397
type: UnificationXref
id: 6248423
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248423

UnificationXref18396
type: UnificationXref
id: Q8S904
db: UniProt

UnificationXref18395
type: UnificationXref
id: 6248421
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248421

UnificationXref18394
type: UnificationXref
id: O49551
db: UniProt

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

UnificationXref18399
type: UnificationXref
id: 6248425
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248425

UnificationXref18398
type: UnificationXref
id: Q9M0V0
db: UniProt

Metabolism of water-soluble vitamins and cofactors
type: Pathway
data source: Provenance1
pathway component: REACT 187915.3
pathway component: REACT 230244.1
pathway component: REACT 247943.1
pathway component: REACT 187833.3
pathway component: REACT 236638.1
pathway component: REACT 187830.3
pathway component: REACT 239210.1
pathway component: REACT 234807.1
pathway component: REACT 247626.1
pathway component: REACT 244898.1
evidence: Evidence1034
xref: UnificationXref11886
xref: RelationshipXref727
xref: UnificationXref11887
pathway order: PathwayStep980
pathway order: PathwayStep1010
pathway order: PathwayStep975
pathway order: PathwayStep973
pathway order: PathwayStep961
pathway order: PathwayStep989
pathway order: PathwayStep1003
pathway order: PathwayStep957
pathway order: PathwayStep955
pathway order: PathwayStep968
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12345
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12346
type: SequenceSite
position status: EQUAL
sequence position: 590

SequenceSite12343
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12344
type: SequenceSite
position status: EQUAL
sequence position: 394

SequenceSite12341
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12342
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12340
type: SequenceSite
position status: EQUAL
sequence position: 236

UniProt:Q9ZP06
type: ProteinReference
xref: UnificationXref10920
organism: http://identifiers.org/taxonomy/3702

UniProt:Q9ZP05
type: ProteinReference
xref: UnificationXref10918
organism: http://identifiers.org/taxonomy/3702

SequenceSite12339
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12338
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12337
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12336
type: SequenceSite
position status: EQUAL
sequence position: 236

Eukaryotic Translation Initiation
type: Pathway
data source: Provenance1
pathway component: REACT 238761.1
pathway component: REACT 230028.1
evidence: Evidence609
xref: RelationshipXref314
xref: UnificationXref7886
xref: UnificationXref7885
pathway order: PathwayStep49
pathway order: PathwayStep588
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12354
type: SequenceSite
position status: EQUAL
sequence position: 521

SequenceSite12355
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12356
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite12357
type: SequenceSite
position status: EQUAL
sequence position: 12

SequenceSite12350
type: SequenceSite
position status: EQUAL
sequence position: 377

SequenceSite12351
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12352
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite12353
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12348
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite12347
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12349
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9712840
type: PublicationXref
id: 9712840
author: Kikuchi, Y
author: Mizutani, M
author: Katada, T
author: Imai, M
author: Hoshino, S
author: Hanaoka, F
author: Ui, M
db: Pubmed
title: Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.
source: J Biol Chem 273:22254-9
year: 1998

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

SequenceSite12360
type: SequenceSite
position status: EQUAL
sequence position: 216

SequenceSite12363
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12364
type: SequenceSite
position status: EQUAL
sequence position: 216

SequenceSite12361
type: SequenceSite
position status: EQUAL
sequence position: 12

SequenceSite12362
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite12367
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12368
type: SequenceSite
position status: EQUAL
sequence position: 216

SequenceSite12365
type: SequenceSite
position status: EQUAL
sequence position: 12

SequenceSite12366
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite12359
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12358
type: SequenceSite
position status: EQUAL
sequence position: 35

http://identifiers.org/pubmed/12445824
type: PublicationXref
id: 12445824
author: Ganapathy, V
author: Inoue, K
author: Zhuang, L
db: Pubmed
title: Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function
source: Biochem Biophys Res Commun 299:465-71
year: 2002

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

herbimycin
type: SmallMoleculeReference
name: herbimycin [ChEBI:5674]
xref: UnificationXref10067

SequenceSite12370
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12371
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12372
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12373
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12374
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12375
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12376
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12377
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12378
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12379
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12369
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12389
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12388
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12387
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12386
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12385
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12384
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12383
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12382
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12381
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12380
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12399
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12398
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12395
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12394
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12397
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12396
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12391
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12390
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12393
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12392
type: SequenceSite
position status: EQUAL
sequence position: 1130

http://identifiers.org/pubmed/7317031
type: PublicationXref
id: 7317031
author: Orford, C R
author: Scott, J E
db: Pubmed
title: Dermatan sulphate-rich proteoglycan associates with rat tail-tendon collagen at the d band in the gap region
source: Biochem. J. 197:213-6
year: 1981

UnificationXref18307
type: UnificationXref
id: 6253608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253608

UnificationXref18308
type: UnificationXref
id: F4JTK8
db: UniProt

UnificationXref18309
type: UnificationXref
id: 6253610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253610

Dual incision reaction in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1436
evidence: Evidence2289
xref: UnificationXref21961
xref: UnificationXref21962
xref: RelationshipXref1814
pathway order: PathwayStep2252
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18315
type: UnificationXref
id: 6253618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253618

UnificationXref18314
type: UnificationXref
id: 6253617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253617

UnificationXref18317
type: UnificationXref
id: REACT_247098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_247098.1

UnificationXref18316
type: UnificationXref
id: 6253620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253620

UnificationXref18311
type: UnificationXref
id: 6253614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253614

UnificationXref18310
type: UnificationXref
id: Q9C6Y8
db: UniProt

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

UnificationXref18313
type: UnificationXref
id: 6253616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253616

UnificationXref18312
type: UnificationXref
id: Q8S9L3
db: UniProt

http://identifiers.org/pubmed/18555778
type: PublicationXref
id: 18555778
author: Aarden, Lucien A
author: Mooi, Wolter J
author: Vredeveld, Liesbeth C W
author: Michaloglou, Chrysiis
author: Peeper, Daniel S
author: Douma, Sirith
author: Desmet, Christophe J
author: Kuilman, Thomas
author: van Doorn, Remco
db: Pubmed
title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
source: Cell 133:1019-31
year: 2008

http://identifiers.org/pubmed/18555777
type: PublicationXref
id: 18555777
author: Augert, Arnaud
author: Popov, Nikolay
author: Takatsu, Yoshihiro
author: Gil, Jesús
author: Acosta, Juan C
author: Banito, Ana
author: Da Costa, Marco
author: Melamed, Jonathan
author: Guijarro, Maria V
author: Raguz, Selina
author: Fumagalli, Marzia
author: Brown, Celia
author: O'Loghlen, Ana
author: Hernando, Eva
author: d'Adda di Fagagna, Fabrizio
author: Bernard, David
db: Pubmed
title: Chemokine signaling via the CXCR2 receptor reinforces senescence
source: Cell 133:1006-18
year: 2008

UnificationXref18306
type: UnificationXref
id: Q9SZM2
db: UniProt

UnificationXref18305
type: UnificationXref
id: 6253606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253606

UnificationXref18304
type: UnificationXref
id: C0Z224
db: UniProt

UnificationXref18303
type: UnificationXref
id: 6253604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253604

UnificationXref18302
type: UnificationXref
id: C0Z3E9
db: UniProt

UnificationXref18301
type: UnificationXref
id: 6253600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253600

UnificationXref18300
type: UnificationXref
id: Q9LPE9
db: UniProt

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

UniProt:F4JMQ0
type: ProteinReference
xref: UnificationXref5852
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

http://identifiers.org/pubmed/11851405
type: PublicationXref
id: 11851405
author: Lin, Zheng
author: Liu, Alice Y-C
author: Manalo, Dominador J
db: Pubmed
title: Redox-dependent regulation of the conformation and function of human heat shock factor 1
source: Biochemistry 41:2580-8
year: 2002

SequenceSite12300
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12302
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12301
type: SequenceSite
position status: EQUAL
sequence position: 1

TCR signaling
type: Pathway
data source: Provenance1
pathway component: REACT 260006.1
pathway component: REACT 241708.1
evidence: Evidence1848
xref: UnificationXref18981
xref: UnificationXref18980
xref: RelationshipXref1603
pathway order: PathwayStep1813
pathway order: PathwayStep1816
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12309
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12307
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12308
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12305
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12306
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12303
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12304
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12313
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12312
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12311
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12310
type: SequenceSite
position status: EQUAL
sequence position: 258

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

Formation of the active cofactor, UDP-glucuronate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction478
pathway component: BiochemicalReaction1176
pathway component: BiochemicalReaction594
evidence: Evidence1739
xref: RelationshipXref1526
xref: UnificationXref18022
xref: UnificationXref18021
pathway order: PathwayStep721
pathway order: PathwayStep913
pathway order: PathwayStep1712
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12314
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12315
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12316
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12317
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12318
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12319
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12320
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12322
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12321
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12324
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12323
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18367646
type: PublicationXref
id: 18367646
author: Ji, JY
author: Herr, A
author: Longworth, Michelle
author: Dyson, NJ
db: Pubmed
title: RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
source: Genes Dev 22:1011-24
year: 2008

SequenceSite12327
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12328
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12325
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12326
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12329
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12331
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12330
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12335
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12334
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12333
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12332
type: SequenceSite
position status: EQUAL
sequence position: 236

http://identifiers.org/pubmed/3931076
type: PublicationXref
id: 3931076
author: Wogan, G N
author: Zhu, J Q
author: Chen, J S
author: Groopman, J D
author: Donahue, P R
db: Pubmed
title: Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography
source: Proc. Natl. Acad. Sci. U.S.A. 82:6492-6
year: 1985

http://identifiers.org/pubmed/21356517
type: PublicationXref
id: 21356517
author: Roach, PJ
author: Glushka, John
author: Contreras, Christopher J
author: Ishihara, Mayumi
author: Heiss, Christian
author: Tagliabracci, Vincent S
author: Hurley, TD
author: Karthik, Chandra
author: Azadi, Parastoo
author: DePaoli-Roach, Anna A
db: Pubmed
title: Phosphate incorporation during glycogen synthesis and Lafora disease
source: Cell Metab. 13:274-82
year: 2011

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

Vitamins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1166
pathway component: BiochemicalReaction1165
evidence: Evidence1721
xref: RelationshipXref1324
xref: UnificationXref17866
xref: UnificationXref17865
pathway order: PathwayStep1693
pathway order: PathwayStep1694
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1349
pathway component: BiochemicalReaction1348
pathway component: BiochemicalReaction1350
evidence: Evidence2105
xref: UnificationXref20862
xref: UnificationXref20863
pathway order: PathwayStep2070
pathway order: PathwayStep2069
pathway order: PathwayStep2068
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

http://identifiers.org/pubmed/9792106
type: PublicationXref
id: 9792106
author: Hazlett, TL
author: Sanchez, SA
author: Jameson, DM
author: Brunet, JE
db: Pubmed
title: Aggregation states of mitochondrial malate dehydrogenase
source: Protein Sci 7:2184-2189
year: 1998

UnificationXref18460
type: UnificationXref
id: REACT_121861
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121861.1

UnificationXref18461
type: UnificationXref
id: 6251203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251203

UnificationXref18462
type: UnificationXref
id: REACT_237277
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237277.1

UnificationXref18463
type: UnificationXref
id: 6251205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251205

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

UnificationXref18464
type: UnificationXref
id: REACT_211077
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_211077.2

UnificationXref18465
type: UnificationXref
id: 6254367
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254367

UnificationXref18466
type: UnificationXref
id: REACT_187606
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187606.3

UnificationXref18467
type: UnificationXref
id: CHEBI:64192
db: ChEBI

UnificationXref18468
type: UnificationXref
id: 2162081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162081

UnificationXref18469
type: UnificationXref
id: REACT_122621
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122621.1

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

UnificationXref18470
type: UnificationXref
id: 6251518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251518

http://identifiers.org/pubmed/17785525
type: PublicationXref
id: 17785525
author: Boyault, Cyril
author: Garrido, Carmen
author: Gilquin, Benoit
author: Kwon, So Hee
author: Caron, Cécile
author: Fritah, Sabrina
author: Khochbin, Saadi
author: Vourc'h, Claire
author: Yao, Tso-Pang
author: Matthias, Patrick
author: Zhang, Yu
db: Pubmed
title: HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
source: Genes Dev. 21:2172-81
year: 2007

UnificationXref18473
type: UnificationXref
id: 2161194
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161194

UnificationXref18474
type: UnificationXref
id: REACT_124629
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124629.1

UnificationXref18471
type: UnificationXref
id: REACT_209861
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_209861.2

UnificationXref18472
type: UnificationXref
id: CHEBI:64112
db: ChEBI

UnificationXref18477
type: UnificationXref
id: REACT_122307
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122307.1

UnificationXref18478
type: UnificationXref
id: CHEBI:64116
db: ChEBI

UnificationXref18475
type: UnificationXref
id: CHEBI:34660
db: ChEBI

UnificationXref18476
type: UnificationXref
id: 2161175
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161175

UnificationXref18479
type: UnificationXref
id: 2161176
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161176

UnificationXref18440
type: UnificationXref
id: REACT_249971
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_249971.1

UnificationXref18441
type: UnificationXref
id: 6247810
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6247810

UnificationXref18446
type: UnificationXref
id: 6247851
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6247851

UnificationXref18447
type: UnificationXref
id: REACT_238090
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_238090.1

UnificationXref18448
type: UnificationXref
id: 6248830
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248830

UnificationXref18449
type: UnificationXref
id: REACT_245418
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245418.1

UnificationXref18442
type: UnificationXref
id: 6247812
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6247812

UnificationXref18443
type: UnificationXref
id: REACT_260820
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260820.1

UnificationXref18444
type: UnificationXref
id: 6254291
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254291

UnificationXref18445
type: UnificationXref
id: REACT_187715
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187715.3

UnificationXref18439
type: UnificationXref
id: 6248829
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248829

UniProt:F4JNC9
type: ProteinReference
xref: UnificationXref5984
organism: http://identifiers.org/taxonomy/3702

DNA Damage Bypass
type: Pathway
data source: Provenance1
pathway component: REACT 232759.1
evidence: Evidence2258
xref: UnificationXref21810
xref: UnificationXref21809
pathway order: PathwayStep2221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18451
type: UnificationXref
id: REACT_218254
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_218254.2

UnificationXref18452
type: UnificationXref
id: 6254294
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254294

UnificationXref18450
type: UnificationXref
id: 6247850
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6247850

UnificationXref18459
type: UnificationXref
id: 2161525
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161525

UnificationXref18457
type: UnificationXref
id: 2161185
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161185

UnificationXref18458
type: UnificationXref
id: REACT_121916
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121916.1

UnificationXref18455
type: UnificationXref
id: REACT_187716
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187716.3

UnificationXref18456
type: UnificationXref
id: CHEBI:421707
db: ChEBI

UnificationXref18453
type: UnificationXref
id: REACT_187717
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187717.3

UnificationXref18454
type: UnificationXref
id: 6254292
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254292

ERK1 activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction508
pathway component: BiochemicalReaction513
pathway component: BiochemicalReaction512
pathway component: BiochemicalReaction510
pathway component: BiochemicalReaction511
pathway component: BiochemicalReaction509
evidence: Evidence797
xref: UnificationXref9997
xref: UnificationXref9996
pathway order: PathwayStep769
pathway order: PathwayStep768
pathway order: PathwayStep770
pathway order: PathwayStep771
pathway order: PathwayStep772
pathway order: PathwayStep773
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

UniProt:F4JND0
type: ProteinReference
xref: UnificationXref5988
organism: http://identifiers.org/taxonomy/3702

UnificationXref18487
type: UnificationXref
id: REACT_261584
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261584.1

UnificationXref18486
type: UnificationXref
id: 6251516
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251516

UnificationXref18489
type: UnificationXref
id: 2162075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162075

UnificationXref18488
type: UnificationXref
id: CHEBI:64172
db: ChEBI

UnificationXref18483
type: UnificationXref
id: CHEBI:421843
db: ChEBI

UnificationXref18482
type: UnificationXref
id: REACT_220377
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220377.2

UnificationXref18485
type: UnificationXref
id: REACT_124205
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124205.1

UnificationXref18484
type: UnificationXref
id: 2161514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161514

UnificationXref18481
type: UnificationXref
id: 6251201
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251201

UnificationXref18480
type: UnificationXref
id: REACT_124587
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124587.1

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

http://identifiers.org/pubmed/9461497
type: PublicationXref
id: 9461497
author: Zhang, H
author: Tai, HH
author: Ensor, CM
db: Pubmed
title: Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
source: Biochem J 330:103-8
year: 1998

UnificationXref18499
type: UnificationXref
id: Q9FYE3
db: UniProt

UnificationXref18498
type: UnificationXref
id: 6248787
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248787

Synthesis of IP2, IP, and Ins in the cytosol
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction700
pathway component: BiochemicalReaction699
pathway component: BiochemicalReaction697
pathway component: BiochemicalReaction698
pathway component: BiochemicalReaction695
pathway component: BiochemicalReaction696
evidence: Evidence1092
xref: RelationshipXref742
xref: UnificationXref12367
xref: UnificationXref12368
pathway order: PathwayStep1065
pathway order: PathwayStep1064
pathway order: PathwayStep1063
pathway order: PathwayStep1062
pathway order: PathwayStep1067
pathway order: PathwayStep1066
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18497
type: UnificationXref
id: A0MFD7
db: UniProt

UnificationXref18496
type: UnificationXref
id: REACT_187604
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187604.3

UnificationXref18495
type: UnificationXref
id: 6254366
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254366

UnificationXref18494
type: UnificationXref
id: REACT_187605
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187605.3

UnificationXref18493
type: UnificationXref
id: 6254365
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254365

Chromosome Maintenance
type: Pathway
data source: Provenance1
pathway component: REACT 260642.1
evidence: Evidence351
xref: UnificationXref4364
xref: UnificationXref4363
pathway order: PathwayStep339
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18492
type: UnificationXref
id: REACT_210378
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_210378.2

UnificationXref18491
type: UnificationXref
id: 6251520
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251520

UnificationXref18490
type: UnificationXref
id: REACT_123917
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123917.1

UniProt:Q37145
type: ProteinReference
xref: UnificationXref1706
organism: http://identifiers.org/taxonomy/3702

SequenceSite12484
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12485
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12482
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12483
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12488
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12489
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12486
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12487
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12480
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12481
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12479
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12493
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12494
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12495
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12496
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12497
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12498
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12499
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

SequenceSite12490
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12491
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12492
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12466
type: SequenceSite
position status: EQUAL
sequence position: 449

SequenceSite12467
type: SequenceSite
position status: EQUAL
sequence position: 1

Butyrate Response Factor 1 (BRF1) destabilizes mRNA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction20
evidence: Evidence31
xref: UnificationXref783
xref: UnificationXref782
pathway order: PathwayStep28
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12464
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12465
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12462
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12463
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12460
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12461
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11447121
type: PublicationXref
id: 11447121
author: Morimoto, R I
author: Eriksson, J E
author: MacKintosh, C
author: Mikhailov, A
author: Hietakangas, V
author: Kallio, M
author: Sistonen, L
author: Morrice, N
author: Rantanen, J O
author: Hellman, J
author: Meinander, A
author: Holmberg, C I
db: Pubmed
title: Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
source: EMBO J. 20:3800-10
year: 2001

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

UniProt:Q9ZPQ5
type: ProteinReference
xref: UnificationXref18070
organism: http://identifiers.org/taxonomy/3702

SequenceSite12459
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12458
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12457
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12475
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12476
type: SequenceSite
position status: EQUAL
sequence position: 449

SequenceSite12477
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12478
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12471
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12472
type: SequenceSite
position status: EQUAL
sequence position: 449

SequenceSite12473
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9199292
type: PublicationXref
id: 9199292
author: Dynlacht, BD
author: Sánchez, I
author: Woo, MS
db: Pubmed
title: p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
source: Mol Cell Biol 17:3566-79
year: 1997

SequenceSite12474
type: SequenceSite
position status: EQUAL
sequence position: 449

SequenceSite12470
type: SequenceSite
position status: EQUAL
sequence position: 449

SequenceSite12469
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q9ZQ19
type: ProteinReference
xref: UnificationXref3222
organism: http://identifiers.org/taxonomy/3702

SequenceSite12468
type: SequenceSite
position status: EQUAL
sequence position: 449

UnificationXref18428
type: UnificationXref
id: B9DH12
db: UniProt

UnificationXref18429
type: UnificationXref
id: 6248775
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248775

UnificationXref18436
type: UnificationXref
id: 6248782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248782

UnificationXref18435
type: UnificationXref
id: 6248781
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248781

UnificationXref18438
type: UnificationXref
id: 6248827
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248827

UnificationXref18437
type: UnificationXref
id: 6248783
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248783

UnificationXref18432
type: UnificationXref
id: 6248778
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248778

UnificationXref18431
type: UnificationXref
id: 6248777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248777

UnificationXref18434
type: UnificationXref
id: 6248780
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248780

UnificationXref18433
type: UnificationXref
id: 6248779
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248779

UnificationXref18430
type: UnificationXref
id: 6248776
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248776

http://identifiers.org/pubmed/9469823
type: PublicationXref
id: 9469823
author: Watanabe, H
author: Gu, L
author: Hong, Y
author: Li, G M
author: McCulloch, S
db: Pubmed
title: ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
source: Nucleic Acids Res. 26:1173-8
year: 1998

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

UnificationXref18419
type: UnificationXref
id: REACT_124282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124282.1

UnificationXref18417
type: UnificationXref
id: REACT_187692
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187692.3

8-oxoguanine [ChEBI:29116]
type: SmallMoleculeReference
name: 8-oxoguanine
xref: UnificationXref21536

UnificationXref18418
type: UnificationXref
id: 1237009
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237009

UnificationXref18427
type: UnificationXref
id: 6248773
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248773

UnificationXref18426
type: UnificationXref
id: Q940K9
db: UniProt

UnificationXref18425
type: UnificationXref
id: 6248771
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248771

UnificationXref18424
type: UnificationXref
id: F4J831
db: UniProt

UnificationXref18423
type: UnificationXref
id: 6248769
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248769

UnificationXref18422
type: UnificationXref
id: O04846
db: UniProt

UnificationXref18421
type: UnificationXref
id: REACT_216507
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_216507.2

UnificationXref18420
type: UnificationXref
id: 6247814
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6247814

UnificationXref18406
type: UnificationXref
id: 6251759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6251759

UnificationXref18407
type: UnificationXref
id: REACT_176021
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176021.3

UnificationXref18408
type: UnificationXref
id: 6254389
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254389

UnificationXref18409
type: UnificationXref
id: REACT_187582
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187582.3

UnificationXref18410
type: UnificationXref
id: CHEBI:33739
db: ChEBI

UnificationXref18412
type: UnificationXref
id: REACT_151393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151393.1

UnificationXref18411
type: UnificationXref
id: 1362383
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1362383

UnificationXref18414
type: UnificationXref
id: 6248432
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248432

UnificationXref18413
type: UnificationXref
id: 6248428
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248428

UnificationXref18416
type: UnificationXref
id: 6254299
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254299

UnificationXref18415
type: UnificationXref
id: REACT_184235
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184235.3

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, Jung-Ja P
author: Wang, M
author: Paschke, R
author: Fu, Zhuji
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref7185

UnificationXref18401
type: UnificationXref
id: 6248429
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248429

UnificationXref18400
type: UnificationXref
id: 6248426
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248426

UnificationXref18405
type: UnificationXref
id: 6248427
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248427

UnificationXref18404
type: UnificationXref
id: REACT_150885
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150885.1

UnificationXref18403
type: UnificationXref
id: 2395504
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2395504

UnificationXref18402
type: UnificationXref
id: CHEBI:33738
db: ChEBI

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

http://identifiers.org/pubmed/20541618
type: PublicationXref
id: 20541618
author: Gilmour, KM
db: Pubmed
title: Perspectives on carbonic anhydrase
source: Comp Biochem Physiol A Mol Integr Physiol 157:193-7
year: 2010

UniProt:Q9ZPF5
type: ProteinReference
xref: UnificationXref17018
organism: http://identifiers.org/taxonomy/3702

SequenceSite12400
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12401
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12405
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12404
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12403
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12402
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12409
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12408
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12407
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12406
type: SequenceSite
position status: EQUAL
sequence position: 1130

SequenceSite12411
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12412
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12410
type: SequenceSite
position status: EQUAL
sequence position: 1130

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

UniProt:Q9ZPI1
type: ProteinReference
xref: UnificationXref7124
organism: http://identifiers.org/taxonomy/3702

UniProt:Q9ZPH4
type: ProteinReference
xref: UnificationXref15013
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

SequenceSite12435
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12436
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12437
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12438
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12439
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12441
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12440
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12443
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12442
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12445
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12444
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12448
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12449
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12446
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12447
type: SequenceSite
position status: EQUAL
sequence position: 1

HSF1-dependent transactivation
type: Pathway
data source: Provenance1
pathway component: REACT 249954.1
pathway component: BiochemicalReaction268
pathway component: BiochemicalReaction269
evidence: Evidence432
xref: RelationshipXref207
xref: UnificationXref5408
xref: UnificationXref5407
pathway order: PathwayStep411
pathway order: PathwayStep414
pathway order: PathwayStep412
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12452
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12451
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12450
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12456
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12455
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12454
type: SequenceSite
position status: EQUAL
sequence position: 451

SequenceSite12453
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12417
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12418
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12419
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12413
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12414
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12415
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12416
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12421
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12420
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12423
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12422
type: SequenceSite
position status: EQUAL
sequence position: 1088

http://identifiers.org/pubmed/9548747
type: PublicationXref
id: 9548747
author: Hammond, PW
author: Cech, TR
db: Pubmed
title: Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation
source: Biochemistry 37:5162-72
year: 1998

SequenceSite12428
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12429
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12426
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12427
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12424
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12425
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12434
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12433
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12432
type: SequenceSite
position status: EQUAL
sequence position: 1088

SequenceSite12431
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12430
type: SequenceSite
position status: EQUAL
sequence position: 1088

UniProt:F4JKI3
type: ProteinReference
xref: UnificationXref1847
organism: http://identifiers.org/taxonomy/3702

UniProt:Q2V4B9
type: ProteinReference
xref: UnificationXref8800
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, Pietro
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

Transport of vitamins, nucleosides, and related molecules
type: Pathway
data source: Provenance1
pathway component: REACT 245136.1
evidence: Evidence747
xref: UnificationXref9385
xref: UnificationXref9386
pathway order: PathwayStep724
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UniProt:F4JKD9
type: ProteinReference
xref: UnificationXref19107
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/11278283
type: PublicationXref
id: 11278283
author: Tsubuki, S
author: Lee, KK
author: Yajima, N
author: Ohyama, T
author: Yonehara, S
db: Pubmed
title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
source: J Biol Chem 276:19276-85
year: 2001

ER to Golgi Transport
type: Pathway
data source: Provenance1
pathway component: REACT 237852.1
evidence: Evidence380
xref: UnificationXref4684
xref: RelationshipXref169
xref: UnificationXref4685
pathway order: PathwayStep363
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/15611369
type: PublicationXref
id: 15611369
author: O'Donnell, CJ
author: Grant, SW
author: Cupples, LA
author: Waterman, MR
author: Brown, NJ
author: Demissie, S
author: Wang, Y
author: Womble, KE
author: Capdevila, JH
author: Gainer, JV
author: Bellamine, A
author: Dawson, EP
author: Guo, CY
db: Pubmed
title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension
source: Circulation 111:63-9
year: 2005

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

UnificationXref18567
type: UnificationXref
id: REACT_237546
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_237546.1

UnificationXref18568
type: UnificationXref
id: 6252293
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252293

UnificationXref18569
type: UnificationXref
id: 6252294
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252294

UnificationXref18563
type: UnificationXref
id: 6252254
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252254

UnificationXref18564
type: UnificationXref
id: 6252255
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252255

UnificationXref18565
type: UnificationXref
id: 6252256
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252256

UnificationXref18566
type: UnificationXref
id: 6252259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252259

UnificationXref18560
type: UnificationXref
id: 6252249
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252249

UnificationXref18561
type: UnificationXref
id: 6252250
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252250

UnificationXref18562
type: UnificationXref
id: Q8H1Q2
db: UniProt

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

http://identifiers.org/pubmed/8330735
type: PublicationXref
id: 8330735
author: Hernandez, N
db: Pubmed
title: TBP, a universal eukaryotic transcription factor?
source: Genes Dev 7:1291-308
year: 1993

UnificationXref18578
type: UnificationXref
id: 6252309
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252309

UniProt:A4FVN8
type: ProteinReference
xref: UnificationXref6752
organism: http://identifiers.org/taxonomy/3702

UnificationXref18579
type: UnificationXref
id: F4HQE2
db: UniProt

UnificationXref18576
type: UnificationXref
id: 6252307
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252307

UnificationXref18577
type: UnificationXref
id: Q9CA97
db: UniProt

UnificationXref18574
type: UnificationXref
id: 6252303
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252303

http://identifiers.org/pubmed/8330740
type: PublicationXref
id: 8330740
author: Greider, CW
author: Collins, K
db: Pubmed
title: Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation
source: Genes Dev 7:1364-76
year: 1993

UnificationXref18575
type: UnificationXref
id: Q0WVC5
db: UniProt

UnificationXref18572
type: UnificationXref
id: F4HUN8
db: UniProt

UnificationXref18573
type: UnificationXref
id: 6252302
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252302

UnificationXref18570
type: UnificationXref
id: F4HUN4
db: UniProt

UnificationXref18571
type: UnificationXref
id: 6252298
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252298

IGF1R signaling cascade
type: Pathway
data source: Provenance1
pathway component: REACT 220088.2
pathway component: IRS-related events triggered by IGF1R
evidence: Evidence2012
xref: UnificationXref19964
xref: UnificationXref19963
pathway order: PathwayStep1977
pathway order: PathwayStep1978
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

M/G1 Transition
type: Pathway
data source: Provenance1
pathway component: REACT 258104.1
evidence: Evidence293
xref: UnificationXref4072
xref: UnificationXref4073
pathway order: PathwayStep283
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18585
type: UnificationXref
id: A8MR89
db: UniProt

UnificationXref18586
type: UnificationXref
id: 6252286
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252286

UnificationXref18587
type: UnificationXref
id: 6252287
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252287

UnificationXref18588
type: UnificationXref
id: F4ITL5
db: UniProt

UnificationXref18589
type: UnificationXref
id: 6252271
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252271

UnificationXref18580
type: UnificationXref
id: 6252311
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252311

UnificationXref18581
type: UnificationXref
id: 6252312
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252312

UnificationXref18582
type: UnificationXref
id: 6252313
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252313

UnificationXref18583
type: UnificationXref
id: Q9C9G6
db: UniProt

UnificationXref18584
type: UnificationXref
id: 6252282
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252282

Sphingolipid de novo biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction940
pathway component: BiochemicalReaction941
pathway component: BiochemicalReaction938
pathway component: BiochemicalReaction939
pathway component: BiochemicalReaction936
pathway component: BiochemicalReaction937
pathway component: BiochemicalReaction934
pathway component: BiochemicalReaction935
pathway component: BiochemicalReaction932
pathway component: BiochemicalReaction933
pathway component: BiochemicalReaction930
pathway component: BiochemicalReaction931
evidence: Evidence1422
xref: RelationshipXref1136
xref: UnificationXref15121
xref: UnificationXref15120
pathway order: PathwayStep1395
pathway order: PathwayStep1394
pathway order: PathwayStep1393
pathway order: PathwayStep1392
pathway order: PathwayStep1391
pathway order: PathwayStep1390
pathway order: PathwayStep1389
pathway order: PathwayStep1386
pathway order: PathwayStep1385
pathway order: PathwayStep1388
pathway order: PathwayStep1396
pathway order: PathwayStep1387
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Synthesis of glycosylphosphatidylinositol (GPI)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1310
pathway component: BiochemicalReaction1309
pathway component: BiochemicalReaction1308
pathway component: BiochemicalReaction1306
pathway component: BiochemicalReaction1307
pathway component: BiochemicalReaction1304
pathway component: BiochemicalReaction1305
pathway component: BiochemicalReaction1303
evidence: Evidence2053
xref: UnificationXref20376
xref: UnificationXref20375
xref: RelationshipXref1688
pathway order: PathwayStep2015
pathway order: PathwayStep2014
pathway order: PathwayStep2013
pathway order: PathwayStep2012
pathway order: PathwayStep2018
pathway order: PathwayStep2017
pathway order: PathwayStep2016
pathway order: PathwayStep2011
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18598
type: UnificationXref
id: 6252265
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252265

UnificationXref18599
type: UnificationXref
id: 6252266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252266

UnificationXref18596
type: UnificationXref
id: 6252263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252263

UnificationXref18597
type: UnificationXref
id: Q94CL6
db: UniProt

UnificationXref18590
type: UnificationXref
id: O80990
db: UniProt

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

UnificationXref18591
type: UnificationXref
id: 6252273
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252273

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

UnificationXref18594
type: UnificationXref
id: 6252278
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252278

UnificationXref18595
type: UnificationXref
id: Q8GXY2
db: UniProt

UnificationXref18592
type: UnificationXref
id: F4JVW1
db: UniProt

UnificationXref18593
type: UnificationXref
id: 6252277
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252277

UnificationXref18531
type: UnificationXref
id: REACT_231718
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231718.1

UnificationXref18530
type: UnificationXref
id: 6248826
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248826

UnificationXref18533
type: UnificationXref
id: REACT_252080
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252080.1

UnificationXref18532
type: UnificationXref
id: 6248825
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248825

UnificationXref18535
type: UnificationXref
id: REACT_187713
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187713.3

UnificationXref18534
type: UnificationXref
id: 6254306
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254306

UniProt:F4JL94
type: ProteinReference
xref: UnificationXref16910
organism: http://identifiers.org/taxonomy/3702

UnificationXref18537
type: UnificationXref
id: REACT_160694
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160694.1

UnificationXref18536
type: UnificationXref
id: 2564759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2564759

UnificationXref18527
type: UnificationXref
id: 6248821
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248821

UnificationXref18528
type: UnificationXref
id: 6248822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248822

UnificationXref18529
type: UnificationXref
id: 6248823
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248823

UnificationXref18522
type: UnificationXref
id: 6248816
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248816

UnificationXref18521
type: UnificationXref
id: 6248815
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248815

UnificationXref18520
type: UnificationXref
id: F4HUC4
db: UniProt

UnificationXref18526
type: UnificationXref
id: 6248820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248820

UniProt:F4JKY6
type: ProteinReference
xref: UnificationXref14966
organism: http://identifiers.org/taxonomy/3702

UnificationXref18525
type: UnificationXref
id: 6248819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248819

UniProt:F4JKY3
type: ProteinReference
xref: UnificationXref14960
organism: http://identifiers.org/taxonomy/3702

UnificationXref18524
type: UnificationXref
id: 6248818
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248818

UnificationXref18523
type: UnificationXref
id: 6248817
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248817

UnificationXref18518
type: UnificationXref
id: 6248810
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248810

di-mu-sulfido-diiron(2+) [ChEBI:33737]
type: SmallMoleculeReference
name: [Fe2S2](2+)
name: [2Fe-2S](2+)
name: di-mu-sulfido-diiron(2+)
name: [Fe2(mu-S)2](2+)
xref: UnificationXref18389

UnificationXref18519
type: UnificationXref
id: REACT_245930
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245930.1

UnificationXref18516
type: UnificationXref
id: 6248811
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248811

http://identifiers.org/pubmed/9949182
type: PublicationXref
id: 9949182
author: Pébusque, MJ
author: Grégoire, MJ
author: Zhang, B
author: Jonveaux, P
author: Popovici, C
author: Lafage-Pochitaloff, M
author: Birnbaum, D
db: Pubmed
title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
source: Blood 93:1381-9
year: 1999

UnificationXref18517
type: UnificationXref
id: REACT_241512
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241512.1

[Fe2S2](+)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(1+)
name: [2Fe-2S](1+)
name: di-mu-sulfido-diiron(1+) [ChEBI:33738]
name: [Fe2(mu-S)2](+)
xref: UnificationXref18402

[Fe2(mu-S)2](0)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(0) [ChEBI:33739]
name: di-mu-sulfido-diiron(0)
name: 2Fe-2S cluster
name: [Fe2S2](0)
xref: UnificationXref18410

http://identifiers.org/pubmed/8250832
type: PublicationXref
id: 8250832
author: Serhan, CN
author: Takahashi, Y
author: Chen, XS
author: Yamamoto, S
author: Romano, M
author: Funk, CD
db: Pubmed
title: Lipoxin synthase activity of human platelet 12-lipoxygenase
source: Biochem J 296:127-33
year: 1993

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

Mitotic G1-G1/S phases
type: Pathway
data source: Provenance1
pathway component: REACT 245653.1
pathway component: REACT 240478.1
pathway component: REACT 187702.3
evidence: Evidence186
xref: UnificationXref3314
xref: UnificationXref3313
pathway order: PathwayStep176
pathway order: PathwayStep151
pathway order: PathwayStep145
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18551
type: UnificationXref
id: 6252242
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252242

UnificationXref18550
type: UnificationXref
id: 6252241
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252241

http://identifiers.org/pubmed/7925341
type: PublicationXref
id: 7925341
author: Bandoh, S
author: Takeda, O
author: Takahashi, E
author: Tanabe, T
author: Ihara, H
author: Miyata, A
author: Yokoyama, C
db: Pubmed
title: Characterization of the human gene (TBXAS1) encoding thromboxane synthase
source: Eur J Biochem 224:273-9
year: 1994

UniProt:Q5XF06
type: ProteinReference
xref: UnificationXref21061
organism: http://identifiers.org/taxonomy/3702

UnificationXref18557
type: UnificationXref
id: Q8LD16
db: UniProt

UnificationXref18556
type: UnificationXref
id: REACT_160420
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160420.1

UnificationXref18559
type: UnificationXref
id: Q6STH5
db: UniProt

SHC1 events in ERBB2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 201916.2
evidence: Evidence1976
xref: UnificationXref19601
xref: UnificationXref19600
pathway order: PathwayStep782
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18558
type: UnificationXref
id: 6252247
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252247

UnificationXref18553
type: UnificationXref
id: REACT_176213
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_176213.3

UnificationXref18552
type: UnificationXref
id: 6252243
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252243

UnificationXref18555
type: UnificationXref
id: 2566513
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2566513

UnificationXref18554
type: UnificationXref
id: CHEBI:26833
db: ChEBI

UnificationXref18549
type: UnificationXref
id: REACT_160751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160751.1

UnificationXref18540
type: UnificationXref
id: REACT_161355
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161355.1

UnificationXref18548
type: UnificationXref
id: 2564757
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2564757

UnificationXref18547
type: UnificationXref
id: 6252240
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252240

UnificationXref18546
type: UnificationXref
id: 6252239
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252239

UnificationXref18545
type: UnificationXref
id: 6252238
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252238

UnificationXref18544
type: UnificationXref
id: Q6NPS8
db: UniProt

UnificationXref18543
type: UnificationXref
id: 6252234
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252234

UnificationXref18542
type: UnificationXref
id: 6252233
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252233

UnificationXref18541
type: UnificationXref
id: Q8L7Z3
db: UniProt

UnificationXref18538
type: UnificationXref
id: CHEBI:49883
db: ChEBI

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

UnificationXref18539
type: UnificationXref
id: 2564758
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2564758

http://identifiers.org/pubmed/8131753
type: PublicationXref
id: 8131753
author: Lieber, MR
author: Harrington, JJ
db: Pubmed
title: The characterization of a mammalian DNA structure-specific endonuclease.
source: EMBO J 13:1235-46
year: 1994

SequenceSite12579
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12578
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12580
type: SequenceSite
position status: EQUAL
sequence position: 122

SequenceSite12587
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12588
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite12585
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12586
type: SequenceSite
position status: EQUAL
sequence position: 122

SequenceSite12583
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12584
type: SequenceSite
position status: EQUAL
sequence position: 122

SequenceSite12581
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

SequenceSite12582
type: SequenceSite
position status: EQUAL
sequence position: 122

UniProt:F4JL62
type: ProteinReference
xref: UnificationXref13906
organism: http://identifiers.org/taxonomy/3702

SequenceSite12589
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:F4JL60
type: ProteinReference
xref: UnificationXref13908
organism: http://identifiers.org/taxonomy/3702

SequenceSite12590
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12591
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12596
type: SequenceSite
position status: EQUAL
sequence position: 129

SequenceSite12597
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12598
type: SequenceSite
position status: EQUAL
sequence position: 129

SequenceSite12599
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12592
type: SequenceSite
position status: EQUAL
sequence position: 134

SequenceSite12593
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12594
type: SequenceSite
position status: EQUAL
sequence position: 129

SequenceSite12595
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18512
type: UnificationXref
id: 6248805
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248805

UnificationXref18513
type: UnificationXref
id: 6248806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248806

UnificationXref18514
type: UnificationXref
id: 6248807
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248807

Bile salt and organic anion SLC transporters
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction449
pathway component: REACT 238829.1
pathway component: BiochemicalReaction455
evidence: Evidence2330
xref: UnificationXref22140
xref: UnificationXref22139
pathway order: PathwayStep690
pathway order: PathwayStep689
pathway order: PathwayStep683
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref11568

UnificationXref18515
type: UnificationXref
id: 6248808
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248808

http://identifiers.org/pubmed/11294880
type: PublicationXref
id: 11294880
author: Lytton, J
author: Li, XF
author: Quednau, BD
author: Yang, R
author: Cai, X
author: Kraev, A
author: Leach, S
author: Perizzolo, M
author: Winkfein, R
author: Dong, H
author: Philipson, KD
db: Pubmed
title: Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3
source: J Biol Chem 276:23161-72
year: 2001

UnificationXref18510
type: UnificationXref
id: 6248803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248803

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

UnificationXref18511
type: UnificationXref
id: Q9SL34
db: UniProt

UnificationXref18509
type: UnificationXref
id: F4IHR4
db: UniProt

UnificationXref18506
type: UnificationXref
id: 6248797
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248797

UnificationXref18505
type: UnificationXref
id: Q8L817
db: UniProt

UnificationXref18508
type: UnificationXref
id: 6248799
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248799

UnificationXref18507
type: UnificationXref
id: 6248798
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248798

UnificationXref18503
type: UnificationXref
id: Q9LN00
db: UniProt

UnificationXref18504
type: UnificationXref
id: 6248795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248795

UnificationXref18501
type: UnificationXref
id: 6248790
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248790

UnificationXref18502
type: UnificationXref
id: 6248791
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248791

UnificationXref18500
type: UnificationXref
id: 6248789
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6248789

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

SequenceSite12542
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12541
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12544
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12543
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12540
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12538
type: SequenceSite
position status: EQUAL
sequence position: 444

Signaling by Leptin
type: Pathway
data source: Provenance1
pathway component: REACT 201916.2
evidence: Evidence2014
xref: UnificationXref19967
xref: UnificationXref19968
pathway order: PathwayStep782
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12539
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12534
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12535
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12536
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12537
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12555
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12554
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12553
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12552
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12551
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12550
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12549
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12547
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12548
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12545
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12546
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12560
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12562
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12561
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12564
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12563
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12566
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12565
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12556
type: SequenceSite
position status: EQUAL
sequence position: 446

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

SequenceSite12557
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12558
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite12559
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12573
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12572
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12571
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12570
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12577
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12576
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12575
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12574
type: SequenceSite
position status: EQUAL
sequence position: 450

UniProt:F4JL01
type: ProteinReference
xref: UnificationXref1754
organism: http://identifiers.org/taxonomy/3702

SequenceSite12569
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12567
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12568
type: SequenceSite
position status: EQUAL
sequence position: 450

UniProt:F4JL00
type: ProteinReference
xref: UnificationXref1752
organism: http://identifiers.org/taxonomy/3702

SequenceSite12500
type: SequenceSite
position status: EQUAL
sequence position: 445

chromosome, centromeric region
type: CellularLocationVocabulary
xref: UnificationXref3664

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

SequenceSite12510
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12511
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12508
type: SequenceSite
position status: EQUAL
sequence position: 445

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

SequenceSite12507
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12506
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12505
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12504
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12503
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12502
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12501
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12509
type: SequenceSite
position status: EQUAL
sequence position: 1

L-arginine removal
type: SequenceModificationVocabulary
xref: UnificationXref10552

SequenceSite12520
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12521
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12522
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12513
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12512
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12515
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12514
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12517
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12516
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12519
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12518
type: SequenceSite
position status: EQUAL
sequence position: 450

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref11851

UniProt:Q2V419
type: ProteinReference
xref: UnificationXref2534
organism: http://identifiers.org/taxonomy/3702

SequenceSite12532
type: SequenceSite
position status: EQUAL
sequence position: 444

SequenceSite12533
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12530
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12531
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12526
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12525
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12524
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12523
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12529
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12528
type: SequenceSite
position status: EQUAL
sequence position: 450

SequenceSite12527
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

SequenceSite12604
type: SequenceSite
position status: EQUAL
sequence position: 543

SequenceSite12605
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12606
type: SequenceSite
position status: EQUAL
sequence position: 545

SequenceSite12607
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12600
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12601
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12602
type: SequenceSite
position status: EQUAL
sequence position: 543

SequenceSite12603
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12608
type: SequenceSite
position status: EQUAL
sequence position: 545

SequenceSite12609
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:F4JLI5
type: ProteinReference
xref: UnificationXref11563
organism: http://identifiers.org/taxonomy/3702

SequenceSite12610
type: SequenceSite
position status: EQUAL
sequence position: 539

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

http://identifiers.org/pubmed/7890667
type: PublicationXref
id: 7890667
author: Liu, SM
author: Cheng, HF
author: Wong, LP
author: King, K
author: Jiang, MJ
author: Chen, CL
author: Lomasney, JW
db: Pubmed
title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
source: J Biol Chem 270:5495-505
year: 1995

UniProt:F4JLJ2
type: ProteinReference
xref: UnificationXref15161
organism: http://identifiers.org/taxonomy/3702

UniProt:F4JLJ3
type: ProteinReference
xref: UnificationXref798
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/19073728
type: PublicationXref
id: 19073728
author: Lenschow, DJ
author: Virgin, HW
author: Giannakopoulos, NV
author: Lai, C
author: Haas, AL
author: Arutyunova, E
db: Pubmed
title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
source: J Virol 83:1602-10
year: 2009

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref12091
type: UnificationXref
id: 6250643
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250643

UnificationXref12092
type: UnificationXref
id: 6250644
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250644

UnificationXref12093
type: UnificationXref
id: 6250645
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250645

UnificationXref12094
type: UnificationXref
id: 6250646
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250646

UnificationXref12090
type: UnificationXref
id: 6250642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250642

UnificationXref12099
type: UnificationXref
id: 6250651
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250651

UnificationXref12095
type: UnificationXref
id: 6250647
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250647

UnificationXref12096
type: UnificationXref
id: 6250648
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250648

UnificationXref12097
type: UnificationXref
id: 6250649
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250649

UnificationXref12098
type: UnificationXref
id: 6250650
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250650

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

UnificationXref12082
type: UnificationXref
id: 6250634
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250634

UnificationXref12083
type: UnificationXref
id: 6250635
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250635

UnificationXref12080
type: UnificationXref
id: 6250632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250632

UnificationXref12081
type: UnificationXref
id: 6250633
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250633

UnificationXref12088
type: UnificationXref
id: 6250640
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250640

UnificationXref12089
type: UnificationXref
id: 6250641
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250641

UnificationXref12086
type: UnificationXref
id: 6250638
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250638

UnificationXref12087
type: UnificationXref
id: 6250639
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250639

UnificationXref12084
type: UnificationXref
id: 6250636
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250636

UnificationXref12085
type: UnificationXref
id: 6250637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250637

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

UnificationXref12070
type: UnificationXref
id: 6250622
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250622

UnificationXref12071
type: UnificationXref
id: 6250623
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250623

UnificationXref12072
type: UnificationXref
id: 6250624
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250624

UnificationXref12073
type: UnificationXref
id: 6250625
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250625

UnificationXref12074
type: UnificationXref
id: 6250626
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250626

UnificationXref12075
type: UnificationXref
id: 6250627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250627

UnificationXref12076
type: UnificationXref
id: 6250628
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250628

UnificationXref12077
type: UnificationXref
id: 6250629
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250629

UnificationXref12078
type: UnificationXref
id: 6250630
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250630

UnificationXref12079
type: UnificationXref
id: 6250631
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250631

UnificationXref12060
type: UnificationXref
id: 6250612
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250612

UnificationXref12061
type: UnificationXref
id: 6250613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250613

UnificationXref12064
type: UnificationXref
id: 6250616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250616

UnificationXref12065
type: UnificationXref
id: 6250617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250617

UnificationXref12062
type: UnificationXref
id: 6250614
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250614

UnificationXref12063
type: UnificationXref
id: 6250615
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250615

UnificationXref12068
type: UnificationXref
id: 6250620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250620

UnificationXref12069
type: UnificationXref
id: 6250621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250621

Signaling by FGFR mutants
type: Pathway
data source: Provenance1
pathway component: Signaling by FGFR1 mutants
evidence: Evidence834
xref: UnificationXref10172
xref: UnificationXref10171
pathway order: PathwayStep810
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref12066
type: UnificationXref
id: 6250618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250618

UnificationXref12067
type: UnificationXref
id: 6250619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250619

UnificationXref12059
type: UnificationXref
id: 6250611
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250611

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

UnificationXref12048
type: UnificationXref
id: 6250602
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250602

UnificationXref12049
type: UnificationXref
id: 140648
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140648

UnificationXref12058
type: UnificationXref
id: 6250610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250610

UnificationXref12057
type: UnificationXref
id: 6250609
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250609

UnificationXref12056
type: UnificationXref
id: 6250608
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250608

UnificationXref12055
type: UnificationXref
id: 6250607
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250607

UnificationXref12054
type: UnificationXref
id: 6250606
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250606

UnificationXref12053
type: UnificationXref
id: 6250605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250605

UnificationXref12052
type: UnificationXref
id: 6250604
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250604

UnificationXref12051
type: UnificationXref
id: 6250603
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250603

UnificationXref12050
type: UnificationXref
id: REACT_2442
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2442.3

http://identifiers.org/pubmed/8104944
type: PublicationXref
id: 8104944
author: Brown, WC
author: Campbell, JL
db: Pubmed
title: Interaction of proliferating cell nuclear antigen with yeast DNA polymerase delta.
source: J Biol Chem 268:21706-10
year: 1993

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref12037
type: UnificationXref
id: 6250482
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250482

UnificationXref12038
type: UnificationXref
id: REACT_205481
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205481.2

UnificationXref12039
type: UnificationXref
id: 6250593
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250593

UnificationXref12045
type: UnificationXref
id: 6250599
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250599

UnificationXref12044
type: UnificationXref
id: 6250598
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250598

UnificationXref12047
type: UnificationXref
id: 6250601
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250601

UnificationXref12046
type: UnificationXref
id: 6250600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250600

UnificationXref12041
type: UnificationXref
id: 6250595
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250595

UnificationXref12040
type: UnificationXref
id: 6250594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250594

UnificationXref12043
type: UnificationXref
id: 6250597
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250597

Activation of gene expression by SREBF (SREBP)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction743
pathway component: BiochemicalReaction742
pathway component: BiochemicalReaction782
pathway component: BiochemicalReaction784
pathway component: BiochemicalReaction783
pathway component: BiochemicalReaction785
evidence: Evidence1220
xref: UnificationXref13386
xref: UnificationXref13385
pathway order: PathwayStep1138
pathway order: PathwayStep1191
pathway order: PathwayStep1193
pathway order: PathwayStep1192
pathway order: PathwayStep1131
pathway order: PathwayStep1194
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref12042
type: UnificationXref
id: 6250596
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250596

UnificationXref12028
type: UnificationXref
id: 6250472
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250472

UnificationXref12029
type: UnificationXref
id: 6250473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250473

UnificationXref12026
type: UnificationXref
id: 6250470
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250470

UnificationXref12027
type: UnificationXref
id: 6250471
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250471

UnificationXref12032
type: UnificationXref
id: 6250476
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250476

UnificationXref12031
type: UnificationXref
id: 6250475
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250475

UnificationXref12030
type: UnificationXref
id: 6250474
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250474

UnificationXref12036
type: UnificationXref
id: 6250480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250480

UnificationXref12035
type: UnificationXref
id: 6250479
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250479

UnificationXref12034
type: UnificationXref
id: 6250478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250478

UnificationXref12033
type: UnificationXref
id: 6250477
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250477

Beta oxidation of octanoyl-CoA to hexanoyl-CoA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction733
evidence: Evidence1138
xref: RelationshipXref826
xref: UnificationXref12718
xref: UnificationXref12717
pathway order: PathwayStep1113
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/16271386
type: PublicationXref
id: 16271386
author: Tomari, Y
author: Bartel, DP
author: Zamore, Phillip D
author: Shin, C
author: Matranga, C
db: Pubmed
title: Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
source: Cell 123:607-20
year: 2005

UnificationXref12015
type: UnificationXref
id: 6234483
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234483

UnificationXref12016
type: UnificationXref
id: 6234484
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234484

UnificationXref12017
type: UnificationXref
id: 6234485
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234485

UnificationXref12018
type: UnificationXref
id: 6234486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234486

UnificationXref12019
type: UnificationXref
id: 6234487
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234487

UnificationXref12021
type: UnificationXref
id: 6234489
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234489

UnificationXref12020
type: UnificationXref
id: 6234488
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234488

UnificationXref12023
type: UnificationXref
id: 6234491
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234491

UnificationXref12022
type: UnificationXref
id: 6234490
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234490

UnificationXref12025
type: UnificationXref
id: 6250469
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250469

UnificationXref12024
type: UnificationXref
id: 6250468
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250468

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

UnificationXref12009
type: UnificationXref
id: 6234478
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234478

UnificationXref12008
type: UnificationXref
id: 6234477
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234477

UnificationXref12007
type: UnificationXref
id: 6234476
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234476

UnificationXref12006
type: UnificationXref
id: 6234475
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234475

UnificationXref12005
type: UnificationXref
id: 6234474
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234474

UnificationXref12004
type: UnificationXref
id: 6234473
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234473

http://identifiers.org/pubmed/19603532
type: PublicationXref
id: 19603532
author: Dubourg, Christèle
author: Solomon, Benjamin D
author: Pineda-Alvarez, Daniel E
author: Bendavid, Claude
author: Zhou, Nan
author: Muenke, Maximilian
author: Ouspenskaia, Maia
author: Hehr, Ute
author: Lacbawan, Felicitas
author: El-Jaick, Kenia B
author: Smeets, Hubert J
author: David, Véronique
author: Bale, Sherri
author: Vélez, Jorge I
author: Odent, Sylvie
author: Roessler, Erich
author: Paulussen, Aimée
db: Pubmed
title: The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
source: Hum. Mutat. 30:E921-35
year: 2009

UnificationXref12013
type: UnificationXref
id: 6250467
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250467

UnificationXref12014
type: UnificationXref
id: 6234482
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234482

UnificationXref12011
type: UnificationXref
id: 6234480
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234480

UnificationXref12012
type: UnificationXref
id: 6234481
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234481

UnificationXref12010
type: UnificationXref
id: 6234479
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234479

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

UnificationXref12000
type: UnificationXref
id: 6234470
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234470

UnificationXref12001
type: UnificationXref
id: 6234471
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234471

UnificationXref12002
type: UnificationXref
id: 6250466
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6250466

UnificationXref12003
type: UnificationXref
id: 6234472
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6234472

UnificationXref18680
type: UnificationXref
id: 6253175
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253175

UnificationXref18681
type: UnificationXref
id: REACT_252697
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_252697.1

UnificationXref18682
type: UnificationXref
id: 6253176
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253176

UnificationXref18683
type: UnificationXref
id: 6253177
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253177

UnificationXref18688
type: UnificationXref
id: 6253171
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253171

UnificationXref18689
type: UnificationXref
id: REACT_246935
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246935.1

UnificationXref18684
type: UnificationXref
id: 6253179
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253179

UnificationXref18685
type: UnificationXref
id: REACT_229522
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229522.1

UnificationXref18686
type: UnificationXref
id: 6242594
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242594

UnificationXref18687
type: UnificationXref
id: 6253169
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253169

http://identifiers.org/pubmed/21413788
type: PublicationXref
id: 21413788
author: Dunaway-Mariano, Debra
author: Wu, Rui
author: Garland, Megan
author: Allen, Karen N
db: Pubmed
title: Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1
source: Biochemistry 50:3045-7
year: 2011

UnificationXref18693
type: UnificationXref
id: REACT_245522
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245522.1

UnificationXref18694
type: UnificationXref
id: 6253858
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253858

UnificationXref18691
type: UnificationXref
id: REACT_241347
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241347.1

UnificationXref18692
type: UnificationXref
id: 6254418
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254418

UnificationXref18690
type: UnificationXref
id: 6254417
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254417

UnificationXref18699
type: UnificationXref
id: REACT_239741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239741.1

UnificationXref18697
type: UnificationXref
id: REACT_246528
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246528.1

UnificationXref18698
type: UnificationXref
id: 6254107
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254107

UnificationXref18695
type: UnificationXref
id: REACT_190892
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_190892.3

UnificationXref18696
type: UnificationXref
id: 6240283
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240283

UnificationXref18678
type: UnificationXref
id: 6253173
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253173

UnificationXref18677
type: UnificationXref
id: 6253172
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253172

UnificationXref18679
type: UnificationXref
id: 6253174
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253174

UnificationXref18674
type: UnificationXref
id: 6240020
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240020

UnificationXref18673
type: UnificationXref
id: 6240017
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240017

UnificationXref18676
type: UnificationXref
id: 6240023
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240023

UnificationXref18675
type: UnificationXref
id: 6240021
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240021

UnificationXref18670
type: UnificationXref
id: 6240008
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240008

UnificationXref18672
type: UnificationXref
id: 6240014
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240014

UnificationXref18671
type: UnificationXref
id: 6240011
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240011

UnificationXref18669
type: UnificationXref
id: 6240005
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240005

UnificationXref18668
type: UnificationXref
id: 6240002
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6240002

UnificationXref18667
type: UnificationXref
id: 6239999
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239999

UnificationXref18666
type: UnificationXref
id: 6239996
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239996

UnificationXref18665
type: UnificationXref
id: 6239993
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239993

UnificationXref18664
type: UnificationXref
id: MOD:00113
db: MOD

UnificationXref18663
type: UnificationXref
id: MOD:00115
db: MOD

UnificationXref18662
type: UnificationXref
id: REACT_248470
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_248470.1

UnificationXref18661
type: UnificationXref
id: 6253892
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253892

UnificationXref18660
type: UnificationXref
id: REACT_245123
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245123.1

Histone acetyltransferases acetylate histones
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction73
pathway component: BiochemicalReaction74
pathway component: BiochemicalReaction72
evidence: Evidence118
xref: UnificationXref2604
xref: UnificationXref2603
pathway order: PathwayStep107
pathway order: PathwayStep109
pathway order: PathwayStep108
display name: HATs acetylate histones
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

Phase 1 - Functionalization of compounds
type: Pathway
data source: Provenance1
pathway component: REACT 243795.1
pathway component: REACT 259498.1
pathway component: REACT 245448.1
pathway component: REACT 226330.2
evidence: Evidence1737
xref: UnificationXref18008
xref: RelationshipXref1503
xref: UnificationXref18007
pathway order: PathwayStep1699
pathway order: PathwayStep1710
pathway order: PathwayStep1705
pathway order: PathwayStep1703
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18659
type: UnificationXref
id: 6253891
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253891

UnificationXref18652
type: UnificationXref
id: 6242060
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242060

UnificationXref18651
type: UnificationXref
id: REACT_257953
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_257953.1

UnificationXref18654
type: UnificationXref
id: 6241970
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6241970

UnificationXref18653
type: UnificationXref
id: 6244199
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244199

UnificationXref18656
type: UnificationXref
id: 6244203
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244203

UnificationXref18655
type: UnificationXref
id: 6244202
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244202

UnificationXref18658
type: UnificationXref
id: REACT_241104
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241104.1

UnificationXref18657
type: UnificationXref
id: 6244205
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244205

UnificationXref18650
type: UnificationXref
id: 6254245
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254245

UnificationXref18648
type: UnificationXref
id: 6254244
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254244

UnificationXref18649
type: UnificationXref
id: REACT_230384
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230384.1

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

UnificationXref18643
type: UnificationXref
id: 6246265
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246265

UnificationXref18642
type: UnificationXref
id: 6246263
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246263

UnificationXref18641
type: UnificationXref
id: 6246261
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246261

UnificationXref18640
type: UnificationXref
id: 6246259
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246259

UnificationXref18647
type: UnificationXref
id: REACT_239631
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_239631.1

UnificationXref18646
type: UnificationXref
id: 6246269
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246269

UnificationXref18645
type: UnificationXref
id: 6246267
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246267

UnificationXref18644
type: UnificationXref
id: 6246266
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246266

Signaling by Rho GTPases
type: Pathway
data source: Provenance1
pathway component: REACT 244177.1
evidence: Evidence1988
xref: UnificationXref19811
xref: RelationshipXref1653
xref: UnificationXref19810
pathway order: PathwayStep1954
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18639
type: UnificationXref
id: 6246257
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246257

UnificationXref18637
type: UnificationXref
id: 6246253
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246253

UnificationXref18638
type: UnificationXref
id: 6246255
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246255

UnificationXref18633
type: UnificationXref
id: 6253857
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253857

UnificationXref18634
type: UnificationXref
id: REACT_220958
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_220958.2

UnificationXref18635
type: UnificationXref
id: 6246249
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246249

UnificationXref18636
type: UnificationXref
id: 6246251
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6246251

http://identifiers.org/pubmed/10681536
type: PublicationXref
id: 10681536
author: Gaither, LA
author: Eide, DJ
db: Pubmed
title: Functional expression of the human hZIP2 zinc transporter
source: J Biol Chem 275:5560-4
year: 2000

UnificationXref18630
type: UnificationXref
id: REACT_260758
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260758.1

UnificationXref18631
type: UnificationXref
id: 6254169
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254169

UnificationXref18632
type: UnificationXref
id: REACT_257577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_257577.1

UnificationXref18627
type: UnificationXref
id: 6242432
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242432

UnificationXref18626
type: UnificationXref
id: 6242430
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242430

UnificationXref18629
type: UnificationXref
id: 6254168
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254168

UnificationXref18628
type: UnificationXref
id: REACT_246498
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246498.1

http://identifiers.org/pubmed/18367721
type: PublicationXref
id: 18367721
author: Skinner, SJ
author: Deleault, KM
author: Whitfield, ML
author: Brooks, SA
author: Gross, RH
author: Townley-Tilson, WH
author: Emmons, J
db: Pubmed
title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
source: RNA 14:888-902
year: 2008

UnificationXref18624
type: UnificationXref
id: REACT_260265
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260265.1

UnificationXref18625
type: UnificationXref
id: 6242429
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242429

UnificationXref18622
type: UnificationXref
id: 6242427
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242427

UnificationXref18623
type: UnificationXref
id: 6242619
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242619

UnificationXref18620
type: UnificationXref
id: REACT_234978
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_234978.1

UnificationXref18621
type: UnificationXref
id: 6242426
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242426

UnificationXref18619
type: UnificationXref
id: 6242620
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242620

UnificationXref18618
type: UnificationXref
id: 6242617
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242617

UnificationXref18617
type: UnificationXref
id: 6242434
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242434

UnificationXref18616
type: UnificationXref
id: Q8VYY5
db: UniProt

UnificationXref18615
type: UnificationXref
id: 6242616
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242616

UnificationXref18610
type: UnificationXref
id: REACT_235794
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235794.1

UnificationXref18611
type: UnificationXref
id: 6254399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254399

UnificationXref18612
type: UnificationXref
id: REACT_187927
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187927.3

UnificationXref18613
type: UnificationXref
id: 6253653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253653

SequenceSite12699
type: SequenceSite
position status: EQUAL
sequence position: 26

UnificationXref18614
type: UnificationXref
id: REACT_180023
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_180023.3

UnificationXref18605
type: UnificationXref
id: 6252315
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252315

UnificationXref18604
type: UnificationXref
id: 6252314
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252314

UnificationXref18607
type: UnificationXref
id: 6252317
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252317

UnificationXref18606
type: UnificationXref
id: 6252316
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252316

UnificationXref18609
type: UnificationXref
id: 6252319
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252319

UnificationXref18608
type: UnificationXref
id: 6252318
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252318

UnificationXref18602
type: UnificationXref
id: 6252291
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252291

UnificationXref18603
type: UnificationXref
id: 6252292
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252292

UnificationXref18600
type: UnificationXref
id: 6252267
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6252267

UnificationXref18601
type: UnificationXref
id: Q0WVF8
db: UniProt

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

SequenceSite12681
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

SequenceSite12680
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12683
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12682
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12685
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12684
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12687
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12686
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12677
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12678
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12679
type: SequenceSite
position status: EQUAL
sequence position: 153

UniProt:F4JLP5
type: ProteinReference
xref: UnificationXref15429
organism: http://identifiers.org/taxonomy/3702

SequenceSite12690
type: SequenceSite
position status: EQUAL
sequence position: 302

SequenceSite12694
type: SequenceSite
position status: EQUAL
sequence position: 484

SequenceSite12693
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12692
type: SequenceSite
position status: EQUAL
sequence position: 484

SequenceSite12691
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12698
type: SequenceSite
position status: EQUAL
sequence position: 158

SequenceSite12697
type: SequenceSite
position status: EQUAL
sequence position: 26

SequenceSite12696
type: SequenceSite
position status: EQUAL
sequence position: 484

SequenceSite12695
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12688
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12689
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12663
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12662
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12665
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12664
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12661
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12660
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12659
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12655
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12656
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12657
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12658
type: SequenceSite
position status: EQUAL
sequence position: 2

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction731
evidence: Evidence1134
xref: RelationshipXref826
xref: UnificationXref12698
xref: UnificationXref12697
pathway order: PathwayStep1109
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12676
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12675
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12674
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite12673
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite12672
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12671
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12670
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12668
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12669
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12666
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12667
type: SequenceSite
position status: EQUAL
sequence position: 153

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

SequenceSite12640
type: SequenceSite
position status: EQUAL
sequence position: 244

SequenceSite12641
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12642
type: SequenceSite
position status: EQUAL
sequence position: 527

SequenceSite12643
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/6022858
type: PublicationXref
id: 6022858
author: Younathan, ES
author: Pynes, GD
db: Pubmed
title: Purification and some properties of inorganic pyrophosphatase from human erythrocytes
source: J Biol Chem 242:2119-23
year: 1967

SequenceSite12634
type: SequenceSite
position status: EQUAL
sequence position: 108

SequenceSite12633
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12636
type: SequenceSite
position status: EQUAL
sequence position: 1192

SequenceSite12635
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12638
type: SequenceSite
position status: EQUAL
sequence position: 184

SequenceSite12637
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12639
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12650
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12653
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12654
type: SequenceSite
position status: EQUAL
sequence position: 153

SequenceSite12651
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12652
type: SequenceSite
position status: EQUAL
sequence position: 153

http://identifiers.org/pubmed/2770297
type: PublicationXref
id: 2770297
author: Thomas, JL
author: Myers, RP
author: Strickler, RC
db: Pubmed
title: Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
source: J Steroid Biochem 33:209-17
year: 1989

UniProt:F4JLM5
type: ProteinReference
xref: UnificationXref7167
organism: http://identifiers.org/taxonomy/3702

SequenceSite12647
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12646
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12645
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12644
type: SequenceSite
position status: EQUAL
sequence position: 346

SequenceSite12649
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12648
type: SequenceSite
position status: EQUAL
sequence position: 154

SequenceSite12620
type: SequenceSite
position status: EQUAL
sequence position: 531

SequenceSite12621
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

SequenceSite12619
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

SequenceSite12616
type: SequenceSite
position status: EQUAL
sequence position: 548

SequenceSite12615
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12618
type: SequenceSite
position status: EQUAL
sequence position: 531

SequenceSite12617
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12612
type: SequenceSite
position status: EQUAL
sequence position: 539

SequenceSite12611
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12614
type: SequenceSite
position status: EQUAL
sequence position: 548

SequenceSite12613
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12631
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12632
type: SequenceSite
position status: EQUAL
sequence position: 535

SequenceSite12630
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite12629
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12628
type: SequenceSite
position status: EQUAL
sequence position: 541

SequenceSite12627
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12626
type: SequenceSite
position status: EQUAL
sequence position: 531

SequenceSite12625
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12624
type: SequenceSite
position status: EQUAL
sequence position: 531

SequenceSite12623
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12622
type: SequenceSite
position status: EQUAL
sequence position: 531

Homologues of EXTL3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21332
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6250158

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LZK5
data source: Provenance1
name: DNAJB11
name: ERdj3
name: Q9LZK5
xref: UnificationXref21321
feature: FragmentFeature6427
cellular location: GO_0005788
comment: Reactome DB_ID: 6250061
display name: HEDJ

phospho-p-S724-ERN1
type: Protein
entity reference: Q9SF12
data source: Provenance1
xref: UnificationXref21297
feature: FragmentFeature6422
feature: ModificationFeature611
cellular location: GO_0005789
comment: Reactome DB_ID: 6241881

Homologues of p-S724-ERN1
type: Protein
data source: Provenance1
member physical entity: phospho-p-S724-ERN1
xref: UnificationXref21299
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6241884

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C5S2
data source: Provenance1
name: IRE1
name: Q9C5S2
xref: UnificationXref21292
feature: FragmentFeature6421
cellular location: GO_0005789
comment: Reactome DB_ID: 6241877
display name: ERN1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SF12
data source: Provenance1
name: Q9SF12
name: IRE1
xref: UnificationXref21290
feature: FragmentFeature6420
cellular location: GO_0005789
comment: Reactome DB_ID: 6241873
display name: ERN1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9CA92
data source: Provenance1
name: Q9CA92
name: DDX11_HUMAN
name: Probable ATP-dependent RNA helicase DDX11
xref: UnificationXref21317
feature: FragmentFeature6426
cellular location: GO_0005654
comment: Reactome DB_ID: 6250089
display name: DDX11

Q84RQ9
type: Protein
entity reference: Q84RQ9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CUL7_HUMAN
name: Cullin-7
xref: UnificationXref21313
feature: FragmentFeature6425
cellular location: GO_0005829
comment: Reactome DB_ID: 6250034
display name: CUL7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LY49
data source: Provenance1
name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
name: Q9LY49
name: CTDS2_HUMAN
xref: UnificationXref21309
feature: FragmentFeature6424
cellular location: GO_0005654
comment: Reactome DB_ID: 6250114
display name: CTDSP2

phospho-p-S724-ERN1
type: Protein
entity reference: Q9C5S2
data source: Provenance1
xref: UnificationXref21298
feature: FragmentFeature6423
feature: ModificationFeature612
cellular location: GO_0005789
comment: Reactome DB_ID: 6241883

http://identifiers.org/pubmed/20042001
type: PublicationXref
id: 20042001
author: Wolf, George
db: Pubmed
title: Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance
source: Nutr. Rev. 68:67-70
year: 2010

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LG66
data source: Provenance1
name: Exostosin-like 3
name: EXTL3_HUMAN
name: Q8LG66
xref: UnificationXref21327
feature: FragmentFeature6428
cellular location: GO_0005789
comment: Reactome DB_ID: 6250153
display name: EXTL3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O23145
data source: Provenance1
name: O23145
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21351
feature: FragmentFeature6435
cellular location: GO_0005829
comment: Reactome DB_ID: 6238148
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C975
data source: Provenance1
name: Exostosin-like 3
name: EXTL3_HUMAN
name: Q9C975
xref: UnificationXref21331
feature: FragmentFeature6430
cellular location: GO_0005789
comment: Reactome DB_ID: 6250157
display name: EXTL3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4HS52
data source: Provenance1
name: Exostosin-like 3
name: EXTL3_HUMAN
name: F4HS52
xref: UnificationXref21329
feature: FragmentFeature6429
cellular location: GO_0005789
comment: Reactome DB_ID: 6250155
display name: EXTL3

Homologues of GOSR2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21347
cellular location: Golgi membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6250170

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4J9Q6
data source: Provenance1
name: FK506-binding protein 14
name: F4J9Q6
name: FKB14_HUMAN
xref: UnificationXref21336
feature: FragmentFeature6431
cellular location: GO_0005788
comment: Reactome DB_ID: 6250084
display name: FKBP14

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FK28
data source: Provenance1
name: Q9FK28
name: Golgi SNAP receptor complex member 2
name: GOSR2_HUMAN
xref: UnificationXref21346
feature: FragmentFeature6433
cellular location: Golgi membrane
comment: Reactome DB_ID: 6250169
display name: GOSR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SJL6
data source: Provenance1
name: Q9SJL6
name: Golgi SNAP receptor complex member 2
name: GOSR2_HUMAN
xref: UnificationXref21344
feature: FragmentFeature6432
cellular location: Golgi membrane
comment: Reactome DB_ID: 6250165
display name: GOSR2

Q39010
type: Protein
entity reference: Q39010
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21350
feature: FragmentFeature6434
cellular location: GO_0005829
comment: Reactome DB_ID: 6238144
display name: GSK3A

Homologues of GSK3A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q39011
member physical entity: Q39010
xref: UnificationXref21360
cellular location: GO_0005829
comment: Reactome DB_ID: 6238181
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q96287
data source: Provenance1
name: Q96287
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21352
feature: FragmentFeature6436
cellular location: GO_0005829
comment: Reactome DB_ID: 6238152
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q39019
data source: Provenance1
name: Q39019
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21353
feature: FragmentFeature6437
cellular location: GO_0005829
comment: Reactome DB_ID: 6238156
display name: GSK3A

UniProt:F4K2E9
type: ProteinReference
xref: UnificationXref6300
organism: http://identifiers.org/taxonomy/3702

Homologues of KDELR3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21375
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6250109

F4JMJ1
type: Protein
entity reference: UniProt:F4JMJ1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HYOU1_HUMAN
name: Hypoxia up-regulated protein 1
xref: UnificationXref21364
feature: FragmentFeature6444
cellular location: GO_0005788
comment: Reactome DB_ID: 6250056
display name: HYOU1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q39012
data source: Provenance1
name: Q39012
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21359
feature: FragmentFeature6443
cellular location: GO_0005829
comment: Reactome DB_ID: 6238180
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VZD5
data source: Provenance1
name: Q8VZD5
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21358
feature: FragmentFeature6442
cellular location: GO_0005829
comment: Reactome DB_ID: 6238176
display name: GSK3A

Q39011
type: Protein
entity reference: Q39011
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21357
feature: FragmentFeature6441
cellular location: GO_0005829
comment: Reactome DB_ID: 6238172
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P43289
data source: Provenance1
name: P43289
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21356
feature: FragmentFeature6440
cellular location: GO_0005829
comment: Reactome DB_ID: 6238168
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P43288
data source: Provenance1
name: P43288
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21355
feature: FragmentFeature6439
cellular location: GO_0005829
comment: Reactome DB_ID: 6238164
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FVS6
data source: Provenance1
name: Q9FVS6
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
xref: UnificationXref21354
feature: FragmentFeature6438
cellular location: GO_0005829
comment: Reactome DB_ID: 6238160
display name: GSK3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LJR8
data source: Provenance1
name: ERD23_HUMAN
name: Q9LJR8
name: ER lumen protein retaining receptor 3
xref: UnificationXref21368
feature: FragmentFeature6445
cellular location: GO_0005789
comment: Reactome DB_ID: 6250100
display name: KDELR3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VWI1
data source: Provenance1
name: ERD23_HUMAN
name: ER lumen protein retaining receptor 3
name: Q8VWI1
xref: UnificationXref21370
feature: FragmentFeature6446
cellular location: GO_0005789
comment: Reactome DB_ID: 6250102
display name: KDELR3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LD09
data source: Provenance1
name: ERD23_HUMAN
name: ER lumen protein retaining receptor 3
name: Q8LD09
xref: UnificationXref21372
feature: FragmentFeature6447
cellular location: GO_0005789
comment: Reactome DB_ID: 6250104
display name: KDELR3

Homologues of PDIA6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9MAU6
xref: UnificationXref21393
cellular location: GO_0005789
comment: Reactome DB_ID: 6250124
comment: Converted from EntitySet in Reactome

O22263
type: Protein
entity reference: O22263
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Protein disulfide-isomerase A5
name: PDIA5_HUMAN
xref: UnificationXref21386
feature: FragmentFeature6451
cellular location: GO_0005789
comment: Reactome DB_ID: 6250095
display name: PDIA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O48773
data source: Provenance1
name: O48773
name: PDIA6_HUMAN
name: Protein disulfide-isomerase A6
xref: UnificationXref21390
feature: FragmentFeature6452
cellular location: GO_0005789
comment: Reactome DB_ID: 6250119
display name: PDIA6

Homologues of KLHDC3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9C6A4
xref: UnificationXref21382
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6250211

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P35402
data source: Provenance1
name: ERD23_HUMAN
name: ER lumen protein retaining receptor 3
name: P35402
xref: UnificationXref21374
feature: FragmentFeature6448
cellular location: GO_0005789
comment: Reactome DB_ID: 6250108
display name: KDELR3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4HTV1
data source: Provenance1
name: KLDC3_HUMAN
name: Kelch domain-containing protein 3
name: F4HTV1
xref: UnificationXref21381
feature: FragmentFeature6450
cellular location: GO_0005829
comment: Reactome DB_ID: 6250210
display name: KLHDC3

Q9C6A4
type: Protein
entity reference: Q9C6A4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KLDC3_HUMAN
name: Kelch domain-containing protein 3
xref: UnificationXref21379
feature: FragmentFeature6449
cellular location: GO_0005829
comment: Reactome DB_ID: 6250208
display name: KLHDC3

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1327
pathway component: BiochemicalReaction1326
pathway component: BiochemicalReaction1329
pathway component: BiochemicalReaction1337
pathway component: BiochemicalReaction1328
pathway component: BiochemicalReaction1336
pathway component: BiochemicalReaction1335
pathway component: BiochemicalReaction1325
pathway component: BiochemicalReaction1334
pathway component: BiochemicalReaction1324
pathway component: BiochemicalReaction1333
pathway component: BiochemicalReaction1332
pathway component: BiochemicalReaction1331
pathway component: BiochemicalReaction1330
pathway component: REACT 259698.1
evidence: Evidence2088
xref: UnificationXref20679
xref: RelationshipXref1742
xref: UnificationXref20678
pathway order: PathwayStep2052
pathway order: PathwayStep2053
pathway order: PathwayStep2040
pathway order: PathwayStep2043
pathway order: PathwayStep2044
pathway order: PathwayStep2041
pathway order: PathwayStep2050
pathway order: PathwayStep2042
pathway order: PathwayStep2051
pathway order: PathwayStep2047
pathway order: PathwayStep2048
pathway order: PathwayStep2045
pathway order: PathwayStep2046
pathway order: PathwayStep2039
pathway order: PathwayStep2049
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Evidence989
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17242360
xref: http://identifiers.org/pubmed/11158296
comment: Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007).

Evidence988
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11994049
xref: http://identifiers.org/pubmed/14514684
comment: The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

Evidence987
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11994049
xref: http://identifiers.org/pubmed/14514684
comment: The adenylyl transferase activity of bifunctional coenzyme A synthase (COASY) catalyzes the transfer of an adenylyl group from ATP to pantetheinephosphate (PPANT) to form dephospho-Coenzyme A (DP-CoA) (Daugherty et al. 2002). The enzyme is associated with the mitochondrial outer membrane (Zhyvoloup et al. 2003).

Evidence986
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/15581364
comment: The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit. While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

http://identifiers.org/pubmed/12949583
type: PublicationXref
id: 12949583
author: van den Bosch, M
author: Lowndes, NF
author: Bree, RT
db: Pubmed
title: The MRN complex: coordinating and mediating the response to broken chromosomes.
source: EMBO Rep 4:844-9
year: 2003

Evidence985
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/12906824
comment: The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).

Evidence984
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4915004
comment: Riboflavin (vitamin B2, E101) is an essential component for the cofactors FAD (flavin-adenine dinucleotide) and FMN (flavin mononucleotide). Together with NAD+ and NADP+, FAD and FMN are important hydrogen carriers and take part in more than 100 redox reactions involved in energy metabolism. Riboflavin is present in many vegetables and meat and during digestion, various flavoproteins from food are degraded and riboflavin is resorbed. The major degradation and excretion product in humans is riboflavin (Rivlin 1970).

Evidence983
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2775236
comment: Cytosolic, homodimeric tartrate-resistant acid phosphatase type 5 (TRAP) catalyzes the hydrolysis of flavin mononucleotide (FMN) to yield riboflavin (RIB) and orthophosphate.

Q9LJE4
type: Protein
entity reference: Q9LJE4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21222
feature: FragmentFeature6387
cellular location: GO_0005743
comment: Reactome DB_ID: 6248218
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21240
data source: Provenance1
name: P21240
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21223
feature: FragmentFeature6388
cellular location: GO_0005743
comment: Reactome DB_ID: 6248219
display name: HSPD1

Homologues of HSPD1(1-573)
type: Protein
data source: Provenance1
member physical entity: Q9LJE4
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21230
cellular location: GO_0005743
comment: Reactome DB_ID: 6248226
comment: Converted from EntitySet in Reactome

UniProt:P20115
type: ProteinReference
xref: UnificationXref15481
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93ZM7
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: Q93ZM7
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21221
feature: FragmentFeature6386
cellular location: GO_0005743
comment: Reactome DB_ID: 6248217
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7B5
data source: Provenance1
name: Q8L7B5
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21226
feature: FragmentFeature6391
cellular location: GO_0005743
comment: Reactome DB_ID: 6248222
display name: HSPD1

Evidence981
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16643857
comment: FMN can be phosphorylated and adenylated to produce the second cofactor from riboflavin origins, flavin adenine dinucleotide (FAD). The enzyme responsible , FMN adenylyltransferase (FLAD1 aka FAD synthase), is cytosolic and transfers a phosphate and an adenyl group from ATP to form FAD.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C667
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
name: Q9C667
xref: UnificationXref21227
feature: FragmentFeature6392
cellular location: GO_0005743
comment: Reactome DB_ID: 6248223
display name: HSPD1

Evidence982
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8001561
comment: Phosphatase action on flavin adenine dinucleotide (FAD) can reform flavin mononucleotide (FMN). The enzyme performing the reaction is nucleotide pyrophosphatase (ENPP1) and it exists as a homodimer on the plasma membrane.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P29197
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
name: P29197
xref: UnificationXref21224
feature: FragmentFeature6389
cellular location: GO_0005743
comment: Reactome DB_ID: 6248220
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21238
data source: Provenance1
name: P21238
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21225
feature: FragmentFeature6390
cellular location: GO_0005743
comment: Reactome DB_ID: 6248221
display name: HSPD1

Evidence980
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3060175
comment: Vitamin B1 (thiamin) is found naturally in certain foodstuffs such as green peas, spinach, liver, bananas, whole grains and legumes. Human diseases associated with thiamin deficiency include beriberi, due to a thiamin-deficient diet, TMRA, due to defects in the SLC19A2 transport protein, and Wernicke-Korsakoff Syndrome, associated with thiamin deficiency in alcoholism (Haas 1988). Thiamin is water-soluble so is not stored in the body. When pyrophosphorylated, thiamin is converted into the coenzyme thiamin pyrophosphate (ThPP, codecarboxylase) which plays an essential role in oxidative decarboxylation and group transfer reactions.

UniProt:F4K2L4
type: ProteinReference
xref: UnificationXref7136
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0Z361
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: C0Z361
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21228
feature: FragmentFeature6393
cellular location: GO_0005743
comment: Reactome DB_ID: 6248224
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q56XV8
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: Q56XV8
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21229
feature: FragmentFeature6394
cellular location: GO_0005743
comment: Reactome DB_ID: 6248225
display name: HSPD1

Evidence999
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16134170
xref: http://identifiers.org/pubmed/22123817
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/9630604
comment: Biotin (Btn) acts as a coenzyme to 4 carboxylases which exist in their inactive apo forms. In the cytosol, these apo carboxylases are biotinylated to their active halo forms by the activity of biotin-protein ligase (HCLS) (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010). HCLS is localised to the cytosol and mitochondrion so can perform this activity in either of these locations. Defects in HLCS causes holocarboxylase synthetase deficiency (HLCS deficiency aka biotin-responsive multiple carboxylase deficiency; MIM:253270). HLCS deficiency is an autosomal recessive disorder whereby deficient HLCS activity results in reduced activity of multiple carboxylases. Symptoms include metabolic acidosis, organic aciduria, lethargy, hypotonia, convulsions and dermatitis (Suzuki et al. 2005). Methylcrotonoyl-CoA carboxylase is most likely functional as a dodecamer, composed of 6 Btn-containing alpha subunits (MCCC1) and six beta subunits (MCCC2). The exact order in which this complex is constructed is unknown.

Evidence998
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10448521
xref: http://identifiers.org/pubmed/20185591
xref: http://identifiers.org/pubmed/21312325
xref: http://identifiers.org/pubmed/19832808
comment: Vitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating with a cobalt atom through four nitrogen atoms. A 5,6-dimethylbenzamidizole base coordinates with the cobalt atom in the lower axial position while a number of different species can coordinate with the cobalt atom in the upper axial position. It is the cobalt-corrin ring complex that gives all Cbls a deep red colour. Only bacteria and archaea are able to synthesize Cbl thus humans need a dietary intake to prevent deficiency (Green 2010, Quadros 2010, Watkins & Rosenblatt 2011). A common semi-synthetic form of the vitamin, cyanocobalamin (CNCbl, where a cyanide group is in the upper axial position), is produced from bacterial hydroxocobalamin and used in many pharmaceuticals, supplements and as a food additive. In mammalian cells, Cbl or CNCbl is converted to two active coenzyme derivatives; methylcobalamin (MetCbl) and adenosylcobalamin (AdoCbl). MetCbl is required for activity of the cytoplasmic enzyme methionine synthase, which converts homocysteine to methionine. AdoCbl is required for activity of the mitochondrial enzyme methylmalonyl CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA (Seetharam 1999). This pathway outlines the intake, transport and metabolism of Cbl and is assumed to be equally applicable to CNCbl.

Evidence995
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22279051
comment: Aldehyde oxidase (AOX1) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. It is active as a homodimer, with each monomer binding two distinct [2Fe2S] clusters, FAD and the molybdenum cofactor. AOX1 plays an important role in the metabolism of drugs based on its broad substrate specificity oxidising aromatic aza-heterocycles and aldehydes (Hartmann et al. 2012).

Evidence994
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10987144
xref: http://identifiers.org/pubmed/15249053
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxine (PDX) to form pyridoxine phosphate (PDXP) (Lee et al. 2000, di Salvo et al. 2004).

Evidence997
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21511966
comment: Multidrug resistance-associated protein 1 (ABCC1, MRP1) can specifically mediate the ATP-dependant export of free cobalamin (Cbl aka vitamin B12) from small intestine cells to the portal vein (Shah et al. 2011).

Evidence996
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10024608
comment: Animals cannot synthesize pyridoxal 5'-phosphate (PLP) which is a ligand in aminotransferases and other enzymes. PLP's accessible derivatives pyridoxine, pyridoxal, and pyridoxamine are traditionally called vitamins B6. They are taken up nutritionally from bacteria and plants, but also created from PLP in the body. The pathways used to recycle PLP from these three compounds can therefore be called vitamin B6 activation as well as PLP salvage. Because of the close similarity of the molecules, only two enzymes are needed for the task (McCormick & Chen, 1999).

http://identifiers.org/pubmed/12692040
type: PublicationXref
id: 12692040
author: Hirschhorn, JN
author: Chitkara, DK
author: Montgomery, RK
author: Grand, RJ
db: Pubmed
title: Changing genes; losing lactase
source: Gut 52:617-9
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZR07
data source: Provenance1
name: FRDA_HUMAN
name: FXN(42-210)
name: Frataxin, intermediate
name: Q9ZR07
xref: UnificationXref21235
feature: FragmentFeature6395
cellular location: GO_0005743
comment: Reactome DB_ID: 6247969
display name: FXN

Homologues of HSCB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21238
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6247976

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7K4
data source: Provenance1
name: HSC20_HUMAN
name: Q8L7K4
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21236
feature: FragmentFeature6396
cellular location: GO_0005743
comment: Reactome DB_ID: 6247973
display name: HSCB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FNG7
data source: Provenance1
name: Q9FNG7
name: HSC20_HUMAN
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21237
feature: FragmentFeature6397
cellular location: GO_0005743
comment: Reactome DB_ID: 6247975
display name: HSCB

Homologues of HSPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9LJE4
xref: UnificationXref21248
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248013

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93ZM7
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: Q93ZM7
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21239
feature: FragmentFeature6398
cellular location: GO_0005743
comment: Reactome DB_ID: 6247980
display name: HSPD1

Evidence990
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11158296
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/15893380
xref: http://identifiers.org/pubmed/13032008
comment: Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

Q9LJE4
type: Protein
entity reference: Q9LJE4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21240
feature: FragmentFeature6399
cellular location: GO_0005743
comment: Reactome DB_ID: 6247984
display name: HSPD1

Evidence991
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/12815048
comment: Panthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every foodstuff.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21240
data source: Provenance1
name: P21240
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21241
feature: FragmentFeature6400
cellular location: GO_0005743
comment: Reactome DB_ID: 6247988
display name: HSPD1

Evidence992
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10987144
xref: http://identifiers.org/pubmed/15249053
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxal (PXL) to form pyridoxal 5'-phosphate (PXLP) (Lee et al. 2000, di Salvo et al. 2004).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P29197
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
name: P29197
xref: UnificationXref21242
feature: FragmentFeature6401
cellular location: GO_0005743
comment: Reactome DB_ID: 6247992
display name: HSPD1

Evidence993
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10987144
xref: http://identifiers.org/pubmed/15249053
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxamine (PXA) to form pyridoxamine phosphate (PXAP) (Lee et al. 2000, di Salvo et al. 2004).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21238
data source: Provenance1
name: P21238
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21243
feature: FragmentFeature6402
cellular location: GO_0005743
comment: Reactome DB_ID: 6247996
display name: HSPD1

Translocation of GLUT4 to the plasma membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction242
pathway component: BiochemicalReaction243
pathway component: BiochemicalReaction240
pathway component: BiochemicalReaction241
evidence: Evidence400
xref: UnificationXref4978
xref: UnificationXref4977
pathway order: PathwayStep383
pathway order: PathwayStep382
pathway order: PathwayStep381
pathway order: PathwayStep380
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZR07
data source: Provenance1
name: FRDA_HUMAN
name: FXN(42-210)
name: Frataxin, intermediate
name: FXN (42-210)
name: Q9ZR07
xref: UnificationXref21253
feature: FragmentFeature6407
cellular location: GO_0005759
comment: Reactome DB_ID: 6248128
display name: FXN

Homologues of HSCB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21256
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248131

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0Z361
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: C0Z361
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21246
feature: FragmentFeature6405
cellular location: GO_0005743
comment: Reactome DB_ID: 6248008
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q56XV8
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: Q56XV8
name: CH60_HUMAN
xref: UnificationXref21247
feature: FragmentFeature6406
cellular location: GO_0005743
comment: Reactome DB_ID: 6248012
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7B5
data source: Provenance1
name: Q8L7B5
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21244
feature: FragmentFeature6403
cellular location: GO_0005743
comment: Reactome DB_ID: 6248000
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C667
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
name: Q9C667
xref: UnificationXref21245
feature: FragmentFeature6404
cellular location: GO_0005743
comment: Reactome DB_ID: 6248004
display name: HSPD1

Homologues of HSPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9LJE4
xref: UnificationXref21266
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248141

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93ZM7
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: Q93ZM7
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21257
feature: FragmentFeature6410
cellular location: GO_0005759
comment: Reactome DB_ID: 6248132
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7K4
data source: Provenance1
name: HSC20_HUMAN
name: Q8L7K4
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21254
feature: FragmentFeature6408
cellular location: GO_0005759
comment: Reactome DB_ID: 6248129
display name: HSCB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FNG7
data source: Provenance1
name: Q9FNG7
name: HSC20_HUMAN
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21255
feature: FragmentFeature6409
cellular location: GO_0005759
comment: Reactome DB_ID: 6248130
display name: HSCB

http://identifiers.org/pubmed/3130248
type: PublicationXref
id: 3130248
author: Shanina, NA
author: Gelfand, VI
author: Chernyak, VY
author: Vaisberg, EA
author: Kuznetsov, SA
author: Magretova, NN
db: Pubmed
title: The quaternary structure of bovine brain kinesin
source: EMBO J 7:353-6
year: 1988

http://identifiers.org/pubmed/11278486
type: PublicationXref
id: 11278486
author: Chong, C
author: Tan, L
author: Lim, L
author: Manser, E
db: Pubmed
title: The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
source: J Biol Chem 276:17347-53
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21238
data source: Provenance1
name: P21238
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21261
feature: FragmentFeature6414
cellular location: GO_0005759
comment: Reactome DB_ID: 6248136
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7B5
data source: Provenance1
name: Q8L7B5
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21262
feature: FragmentFeature6415
cellular location: GO_0005759
comment: Reactome DB_ID: 6248137
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C667
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
name: Q9C667
xref: UnificationXref21263
feature: FragmentFeature6416
cellular location: GO_0005759
comment: Reactome DB_ID: 6248138
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0Z361
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: C0Z361
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21264
feature: FragmentFeature6417
cellular location: GO_0005759
comment: Reactome DB_ID: 6248139
display name: HSPD1

Q9LJE4
type: Protein
entity reference: Q9LJE4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21258
feature: FragmentFeature6411
cellular location: GO_0005759
comment: Reactome DB_ID: 6248133
display name: HSPD1

PPi
type: SmallMoleculeReference
name: PPi [ChEBI:29888]
xref: UnificationXref5604

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21240
data source: Provenance1
name: P21240
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
xref: UnificationXref21259
feature: FragmentFeature6412
cellular location: GO_0005759
comment: Reactome DB_ID: 6248134
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P29197
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: CH60_HUMAN
name: P29197
xref: UnificationXref21260
feature: FragmentFeature6413
cellular location: GO_0005759
comment: Reactome DB_ID: 6248135
display name: HSPD1

UniProt:P51818
type: ProteinReference
xref: UnificationXref5270
organism: http://identifiers.org/taxonomy/3702

UniProt:F4K2K3
type: ProteinReference
xref: UnificationXref4708
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q56XV8
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSP60
name: Q56XV8
name: CH60_HUMAN
xref: UnificationXref21265
feature: FragmentFeature6418
cellular location: GO_0005759
comment: Reactome DB_ID: 6248140
display name: HSPD1

Endoplasmin
type: Protein
entity reference: Q9STX5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ENPL_HUMAN
name: HSP90B1
xref: UnificationXref21282
feature: FragmentFeature6419
cellular location: GO_0005788
comment: Reactome DB_ID: 6250186
display name: Q9STX5

Homologues of ERN1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21293
cellular location: GO_0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6241878

http://identifiers.org/pubmed/15585754
type: PublicationXref
id: 15585754
author: Hicklin, DJ
author: Ellis, LM
db: Pubmed
title: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
source: J Clin Oncol 23:1011-27
year: 2005

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

http://identifiers.org/pubmed/18772128
type: PublicationXref
id: 18772128
author: Riekhof, WR
author: Voelker, DR
author: Gijon, MA
author: Zarini, S
author: Murphy, RC
db: Pubmed
title: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
source: J Biol Chem 283:30235-45
year: 2008

http://identifiers.org/pubmed/10393322
type: PublicationXref
id: 10393322
author: Yoshioka, S
author: Ishida, N
author: Takeuchi, M
author: Chiba, Y
author: Kawakita, M
db: Pubmed
title: Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter
source: J Biochem 126:68-77
year: 1999

http://identifiers.org/pubmed/23604073
type: PublicationXref
id: 23604073
author: Ablasser, A
author: Hopfner, KP
author: Deimling, Tobias
author: Hornung, V
author: Cavlar, Taner
db: Pubmed
title: Species-specific detection of the antiviral small-molecule compound CMA by STING
source: EMBO J. 32:1440-50
year: 2013

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93YV6
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21398
feature: FragmentFeature6456
cellular location: GO_0005829
comment: Reactome DB_ID: 6241984
display name: Q93YV6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LF36
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21399
feature: FragmentFeature6457
cellular location: GO_0005829
comment: Reactome DB_ID: 6241985
display name: Q8LF36

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O04375
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21400
feature: FragmentFeature6458
cellular location: GO_0005829
comment: Reactome DB_ID: 6241986
display name: O04375

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SV41
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21401
feature: FragmentFeature6459
cellular location: GO_0005829
comment: Reactome DB_ID: 6241987
display name: Q9SV41

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZQY6
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21402
feature: FragmentFeature6460
cellular location: GO_0005829
comment: Reactome DB_ID: 6241988
display name: Q9ZQY6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LU89
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21403
feature: FragmentFeature6461
cellular location: GO_0005829
comment: Reactome DB_ID: 6241989
display name: Q9LU89

Homologues of PPP2R5B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Protein7700
xref: UnificationXref21405
cellular location: GO_0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6241991

Q9MAU6
type: Protein
entity reference: Q9MAU6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PDIA6_HUMAN
name: Protein disulfide-isomerase A6
xref: UnificationXref21392
feature: FragmentFeature6453
cellular location: GO_0005789
comment: Reactome DB_ID: 6250123
display name: PDIA6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O04376
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21397
feature: FragmentFeature6455
cellular location: GO_0005829
comment: Reactome DB_ID: 6241983
display name: O04376

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LVE2
data source: Provenance1
name: 2A5B_HUMAN
name: PPP2R5B
name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
xref: UnificationXref21396
feature: FragmentFeature6454
cellular location: GO_0005829
comment: Reactome DB_ID: 6241982
display name: Q9LVE2

http://identifiers.org/pubmed/8386433
type: PublicationXref
id: 8386433
author: Horrobin, DF
db: Pubmed
title: Fatty acid metabolism in health and disease: the role of delta-6-desaturase
source: Am J Clin Nutr 57:732S-736S; discussion 736S-737S
year: 1993

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

UniProt:F4JQU2
type: ProteinReference
xref: UnificationXref1524
organism: http://identifiers.org/taxonomy/3702

UniProt:F4JQU1
type: ProteinReference
xref: UnificationXref1532
organism: http://identifiers.org/taxonomy/3702

UniProt:F4K347
type: ProteinReference
xref: UnificationXref3843
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/22118461
type: PublicationXref
id: 22118461
author: Desai, Arshad
author: Hombauer, Hans
author: Smith, Catherine E
author: Campbell, Christopher S
author: Kolodner, Richard D
db: Pubmed
title: Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
source: Cell 147:1040-53
year: 2011

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

http://identifiers.org/pubmed/11130078
type: PublicationXref
id: 11130078
author: Sato, S
author: Takeda, K
author: Wagner, H
author: Sanjo, H
author: Takeuchi, O
author: Hoshino, K
author: Matsumoto, M
author: Kaisho, T
author: Kawai, T
author: Hemmi, H
author: Akira, S
db: Pubmed
title: A Toll-like receptor recognizes bacterial DNA
source: Nature 408:740-5
year: 2000

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

Membrane Trafficking
type: Pathway
data source: Provenance1
pathway component: REACT 250392.1
pathway component: REACT 255763.1
pathway component: Translocation of GLUT4 to the plasma membrane
pathway component: REACT 190928.3
pathway component: ER to Golgi Transport
evidence: Evidence401
xref: UnificationXref4980
xref: UnificationXref4979
xref: RelationshipXref180
pathway order: PathwayStep379
pathway order: PathwayStep364
pathway order: PathwayStep377
pathway order: PathwayStep384
pathway order: PathwayStep374
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

UniProt:Q94LA4
type: ProteinReference
xref: UnificationXref17432
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

carboxylic acid [ChEBI:33575]
type: SmallMoleculeReference
name: acidos carboxilicos
name: acide carboxylique
name: acido carboxilico
name: Carbonsaeure
name: RC(=O)OH
name: acides carboxyliques
name: Carbonsaeuren
name: carboxylic acid
name: Karbonsaeure
xref: UnificationXref15191

UniProt:Q6EWX0
type: ProteinReference
xref: UnificationXref3189
organism: http://identifiers.org/taxonomy/3702

UniProt:Q6EWX1
type: ProteinReference
xref: UnificationXref3196
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/9305837
type: PublicationXref
id: 9305837
author: Mäder, A W
author: Luger, K
author: Richmond, R K
author: Sargent, D F
author: Richmond, T J
db: Pubmed
title: Crystal structure of the nucleosome core particle at 2.8 A resolution
source: Nature 389:251-60
year: 1997

http://identifiers.org/pubmed/8399223
type: PublicationXref
id: 8399223
author: Tanhauser, SM
author: Chen, X
author: Silverman, DN
author: Laipis, PJ
author: Kresge, AJ
author: Tu, C
db: Pubmed
title: Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III
source: Biochemistry 32:10757-62
year: 1993

UnificationXref18700
type: UnificationXref
id: 6254108
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254108

UnificationXref18701
type: UnificationXref
id: REACT_229568
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_229568.1

UnificationXref18702
type: UnificationXref
id: 6253859
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253859

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

UniProt:P49078
type: ProteinReference
xref: UnificationXref16581
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/19767751
type: PublicationXref
id: 19767751
author: Kosako, H
author: Hattori, S
author: Taniguchi, H
author: Kose, S
author: Ushiyama, M
author: Nishida, E
author: Imamoto, N
author: Aranami, C
author: Yamaguchi, N
db: Pubmed
title: Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
source: Nat Struct Mol Biol 16:1026-35
year: 2009

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

UnificationXref18712
type: UnificationXref
id: Q9ZW72
db: UniProt

UnificationXref18713
type: UnificationXref
id: 6244509
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244509

UnificationXref18710
type: UnificationXref
id: Q9C902
db: UniProt

UnificationXref18711
type: UnificationXref
id: 6244504
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244504

UnificationXref18709
type: UnificationXref
id: 6236073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6236073

UnificationXref18708
type: UnificationXref
id: 6244498
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244498

UnificationXref18707
type: UnificationXref
id: 6244494
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244494

UnificationXref18706
type: UnificationXref
id: 6244491
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244491

UnificationXref18705
type: UnificationXref
id: 6244486
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244486

UnificationXref18704
type: UnificationXref
id: Q9M8J5
db: UniProt

UnificationXref18703
type: UnificationXref
id: REACT_184953
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_184953.3

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

UnificationXref18716
type: UnificationXref
id: Q9FH74
db: UniProt

UnificationXref18717
type: UnificationXref
id: 6244519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244519

UnificationXref18714
type: UnificationXref
id: Q84WF3
db: UniProt

UnificationXref18715
type: UnificationXref
id: 6244514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244514

http://identifiers.org/pubmed/15838516
type: PublicationXref
id: 15838516
author: Cobrinik, D
db: Pubmed
title: Pocket proteins and cell cycle control
source: Oncogene 24:2796-809
year: 2005

UnificationXref18718
type: UnificationXref
id: Q1PE89
db: UniProt

UnificationXref18719
type: UnificationXref
id: 6244524
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244524

UnificationXref18720
type: UnificationXref
id: Q6R2K3
db: UniProt

Evidence958
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2581946
xref: http://identifiers.org/pubmed/7396409
comment: Cytosolic ribulose-5-phosphate-3-epimerase (RPE) catalyzes the reversible interconversion of D-xylulose 5-phosphate and D-ribulose 5-phosphate (Bose and 1985). The electrophoretic properties of RPE activity detected in extracts of mouse-human somatic cell hybrids suggest that the active form of the enzyme is a homodimer (Spencer and Hopkinson 1980).

Evidence959
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9357955
comment: Cytosolic transketolase catalyzes the reversible reaction of D-xylulose 5-phosphate and D-ribose 5-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

UnificationXref18724
type: UnificationXref
id: F4JWD4
db: UniProt

UnificationXref18723
type: UnificationXref
id: 6244534
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244534

UnificationXref18722
type: UnificationXref
id: O80719
db: UniProt

UnificationXref18721
type: UnificationXref
id: 6244529
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244529

Evidence952
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15175331
xref: http://identifiers.org/pubmed/10801319
comment: Cytosolic UDP-galactose 4-epimerase catalyzes the interconversion of UDP-D-galactose and UDPglucose (Schulz et al. 2004). The active form of the enzyme is a homodimer with one molecule of bound NAD per monomer (Thoden et al. 2000).

Evidence953
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11261429
xref: PublicationXref1995
comment: The main sources of galactose in the human diet are milk and milk products. The disaccharide lactose from these sources is hydrolyzed in the intestine to its constituent monosaccharides, glucose and galactose. Galactose is metabolized primarily in the liver in a sequence of three reactions that yield one molecule of glucose 1-phosphate per molecule of galactose. First, it is phosphorylated to yield galactose 1-phosphate. Then, galactose 1-phosphate and UDP-glucose react to form UDP-galactose and glucose 1-phosphate, and UDP-galactose undergoes epimerization to form UDP-glucose. In a reaction shared with other pathways, glucose 1-phosphate can be converted into glucose 6-phosphate (Holton et al. 2001; Elsas and Lai 2001).

Evidence950
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1991
xref: PublicationXref1990
comment: Fructose occurs naturally in foods as a free monosaccharide and as a component of the disaccharide sucrose. It is also widely used as a sweetener. In the body, fructose is converted to dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, two intermediates in the glycolytic pathway, in a sequence of three reactions: fructose is phosphorylated, then cleaved by aldolase to yield dihydroxyacetone phosphate and D-glyceraldehyde, and the latter compound is phosphorylated to yield D-glyceraldehyde 3-phosphate. Other pathways exist for the conversion of D-glyceraldehyde to intermediates of glycolysis, but these appear to play only a minor role in normal fructose metabolism. The cleavage of fructose 1-phosphate is catalyzed by the same enzyme that catalyzes the reversible cleavage of fructose 1,6-bisphosphate in glycolysis. The isoform of this enzyme found in liver, kidney, and intestine (B) is approximately equally active with fructose 1-phosphate and fructose 1,6-bisphosphate as substrates, while the muscle and brain isoforms (A and C, respectively), have little activity with fructose 1-phosphate. Fructose metabolism thus occurs mainly in tissues expressing the B isoform, and mutations that affect the catalytic activity of this isoform are associated with hereditary fructose intolerance (Steinmann et al. 2001).

Evidence951
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1897530
comment: Cytosolic galactose-1-phosphate uridylyltransferase (GALT) catalyzes the reaction of alpha-D-galactose 1-phosphate and UDP glucose to form D-glucose 1-phosphate and UDP galactose (Reichardt et al. 1991).

Evidence956
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9920387
xref: http://identifiers.org/pubmed/3932573
xref: http://identifiers.org/pubmed/3994686
comment: Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).

Evidence957
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2581946
xref: http://identifiers.org/pubmed/7396409
comment: Cytosolic ribulose-5-phosphate-3-epimerase (RPE) catalyzes the reversible interconversion of D-ribulose 5-phosphate and D-xylulose 5-phosphate (Bose and 1985). The electrophoretic properties of RPE activity detected in extracts of mouse-human somatic cell hybrids suggest that the active form of the enzyme is a homodimer (Spencer and Hopkinson 1980).

Evidence954
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5666113
xref: http://identifiers.org/pubmed/10745013
comment: Cytosolic glucose-6-phosphate dehydrogenase (G6PD) catalyzes the reaction of glucose 6-phosphate and NADP+ to form D-glucono-1,5-lactone 6-phosphate and , and NADPH + H+. Biochemical studies indicate that both G6PD dimers and tetramers are catalytically active and capable or forming under physiological conditions in vivo (Au et al. 2000). Mutations that reduce the catalytic efficientcy of G6PD are remarkably common in human populations; these appear to have a protective effect against malaria (e.g., Luzzatto and Afolayan 1968).

Evidence955
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10518023
xref: http://identifiers.org/pubmed/3932573
comment: Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

UniProt:P24636
type: ProteinReference
xref: UnificationXref20001
organism: http://identifiers.org/taxonomy/3702

UnificationXref18725
type: UnificationXref
id: 6244539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244539

UnificationXref18726
type: UnificationXref
id: Q9LUL4
db: UniProt

UnificationXref18727
type: UnificationXref
id: 6244544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244544

UnificationXref18728
type: UnificationXref
id: A0MEY6
db: UniProt

UnificationXref18729
type: UnificationXref
id: 6244549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244549

Evidence947
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/183599
xref: http://identifiers.org/pubmed/4320262
comment: Cytosolic glycogen breakdown occurs via the same chemical steps in all tissues but is separately regulated via tissue specific isozymes and signaling pathways that enable distinct physiological fates for liver glycogen and that in other tissues. Glycogen phosphorylase, which can be activated by phosphorylase kinase, catalyzes the removal of glucose residues as glucose 1-phosphate from the ends of glycogen branches. The final four residues of each branch are removed in two steps catalyzed by debranching enzyme, and further glycogen phosphorylase activity completes the process of glycogen breakdown. The figure shows the actions of phosphorylase and debranching enzyme. The first glucose residue in each branch is released as free glucose; all other residues are released as glucose 1-phosphate. The latter molecule can be converted to glucose 6-phosphate in a step shared with other pathways (Villar-Palasi and Larner 1970; Hers 1976). Glycogen can also be taken up into lysosomes, where it is normally broken done by the action of a single enzyme, lysosomal alpha-glucosidase (GAA).

UniProt:F4K3A9
type: ProteinReference
xref: UnificationXref15958
organism: http://identifiers.org/taxonomy/3702

Evidence948
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Glucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood cells. Glucose utilization begins with its uptake by cells and conversion to glucose 6-phosphate, which cannot traverse the cell membrane. Fates open to cytosolic glucose 6-phosphate include glycolysis to yield pyruvate, glycogen synthesis, and the pentose phosphate pathway. In some tissues, notably the liver and kidney, glucose 6-phosphate can be synthesized from pyruvate by the pathway of gluconeogenesis.

UnificationXref18731
type: UnificationXref
id: 6244554
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244554

Evidence949
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8535439
xref: http://identifiers.org/pubmed/11679716
xref: http://identifiers.org/pubmed/2649152
comment: Cytosolic aldolase B (ALDOB) catalyzes the reaction of D-fructose 1-phosphate to form dihydroxyacetone phosphate and D-glyceraldehyde (Sakakibara et al. 1989). The active form of the enzyme is a tetramer (Dalby et al. 2001). Deficiencies in the enzyme are associated with hereditary fructose intolerance in vivo (e.g., Tolan 1995).

UnificationXref18730
type: UnificationXref
id: Q6R2J8
db: UniProt

http://identifiers.org/pubmed/9153396
type: PublicationXref
id: 9153396
author: Vousden, KH
author: Kubbutat, MH
author: Jones, SN
db: Pubmed
title: Regulation of p53 stability by Mdm2.
source: Nature 387:299-303
year: 1997

UnificationXref18733
type: UnificationXref
id: 6244557
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244557

http://identifiers.org/pubmed/9153395
type: PublicationXref
id: 9153395
author: Haupt, Y
author: Maya, R
author: Oren, M
author: Kazaz, A
db: Pubmed
title: Mdm2 promotes the rapid degradation of p53.
source: Nature 387:296-9
year: 1997

UnificationXref18732
type: UnificationXref
id: Q84UJ3
db: UniProt

UnificationXref18735
type: UnificationXref
id: 6244562
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244562

UnificationXref18734
type: UnificationXref
id: Q9LXT2
db: UniProt

Evidence940
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10949035
comment: Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).

Evidence941
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10949035
comment: Cytosolic, non-phosphorylated PGYM dimers (b form) complexed with AMP can reversibly dissociate (Rath et al. 2000).

Evidence942
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2667896
xref: http://identifiers.org/pubmed/10949035
comment: The PYGM and PYGB forms of glycogen phosphorylase catalyze the reaction of orthophosphate and glycogen-glycogenin 1 to form D-glucose 1-phosphate and limit dextrin-glycogenin 1. This reaction occurs on the surfaces of cytosolic glycogen granules. The phosphorylated forms of PYGM and PYGB dimers (a form) are catalytically active; the non-phosphorylated dimers (b form) become active when complexed with AMP. In the body, this reaction takes place in tissues other than the liver where its sensitivity to AMP allows glucose mobilization in response to acute energy needs of the individual cell, and hormonally mediated phosphorylation can stimulate increased glucose production, still for use by the individual producing cell, in response to stress signals. These reactions have not been characterized in detail but are inferred to occur from the very close similarity among PGYM, PGYB, and PGYL (Newgard et al. 1989; Rath et al. 2000).

Evidence943
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2667896
xref: http://identifiers.org/pubmed/10949035
comment: The phosphorylated PYGL dimer (a form) of glycogen phosphorylase catalyzes the reaction of orthophosphate and glycogen-glycogenin 1 to form D-glucose 1-phosphate and limit dextrin-glycogenin 1. This reaction occurs on the surfaces of cytosolic glycogen granules. Non-phosphorylated PYGL dimers (b form) are catalytically inactive even in the presence of AMP. In the body, this reaction takes place in the liver where its dependence on hormonally stimulated PYGL phosphorylation (and lack of sensitivity to AMP) allow glucose mobilization in response to a demand for glucose from the rest of the body (Newgard et al. 1989; Rath et al. 2000).

Evidence944
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2667896
xref: http://identifiers.org/pubmed/10949035
comment: The PYGM and PYGB forms of glycogen phosphorylase catalyze the reaction of orthophosphate and poly((1,4) alpha glucosyl) glycogenin-1 to form D-glucose 1-phosphate and glycogenin-1. This reaction occurs on the surfaces of cytosolic glycogen granules. The phosphorylated forms of PYGM and PYGB dimers (a form) are catalytically active; the non-phosphorylated dimers (b form) become active when complexed with AMP. In the body, this reaction takes place in tissues other than the liver where its sensitivity to AMP allows glucose mobilization in response to acute energy needs of the individual cell, and hormonally mediated phosphorylation can stimulate increased glucose production, still for use by the individual producing cell, in response to stress signals. These reactions have not been characterized in detail but are inferred to occur from the very close similarity among PGYM, PGYB, and PGYL (Newgard et al. 1989; Rath et al. 2000).

Evidence945
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2667896
xref: http://identifiers.org/pubmed/10949035
comment: The phosphorylated PYGL dimer (a form) of glycogen phosphorylase catalyzes the reaction of orthophosphate and poly((1,4)-alpha-glucosyl) glycogenin-2 to form D-glucose 1-phosphate and glycogenin-2. This reaction occurs on the surfaces of cytosolic glycogen granules. Non-phosphorylated PYGL dimers (b form) are catalytically inactive even in the presence of AMP. In the body, this reaction takes place in the liver where its dependence on hormonally stimulated PYGL phosphorylation (and lack of sensitivity to AMP) allow glucose mobilization in response to a demand for glucose from the rest of the body (Newgard et al. 1989; Rath et al. 2000).

Evidence946
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7902568
comment: Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZR07
data source: Provenance1
name: FRDA_HUMAN
name: FXN(1-210)
name: Frataxin precursor
name: Q9ZR07
xref: UnificationXref21217
feature: FragmentFeature6383
cellular location: GO_0005743
comment: Reactome DB_ID: 6248213
display name: FXN

Evidence971
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: These pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the body (as glycogen) and its mobilization during a short fast; and 3) the synthesis of glucose from pyruvate during extended fasts.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q56XV8
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: Q56XV8
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21214
feature: FragmentFeature6382
cellular location: GO_0005758
comment: Reactome DB_ID: 6248242
display name: HSPD1

Evidence970
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2168892
xref: http://identifiers.org/pubmed/8702702
xref: http://identifiers.org/pubmed/2444588
xref: http://identifiers.org/pubmed/4358634
xref: http://identifiers.org/pubmed/2537655
xref: http://identifiers.org/pubmed/8253776
xref: http://identifiers.org/pubmed/4328836
xref: http://identifiers.org/pubmed/14392173
comment: 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) is a key intermediate in both the de novo and salvage pathways of purine and pyrimidine synthesis. PRPP and the enzymatic activity responsible for its synthesis were first described by Kornberg et al. (1955). The enzyme, phosphoribosyl pyrophosphate synthetase 1, has been purified from human erythrocytes and characterized biochemically. The purified enzyme readily forms multimers; its smallest active form appears to be a dimer and for simplicity it is annotated as a dimer here. It specifically catalyzes the transfer of pyrophosphate from ATP or dATP to D-ribose 5-phosphate, and has an absolute requirement for Mg++ and orthophosphate (Fox and Kelley 1971; Roth et al. 1974). The significance of the reaction with dATP in vivo is unclear, as the concentration of cytosolic dATP is normally much lower than that of ATP. The importance of this enzyme for purine synthesis in vivo has been established by demonstrating excess phosphoribosyl pyrophosphate synthetase activity, correlated with elevated enzyme levels or altered enzyme properties, in individuals whose rates of uric acid production are constitutively abnormally high (Becker and Kim 1987; Roessler et al. 1993). Molecular cloning studies have revealed the existence of two additional genes that encode phosphoribosyl pyrophosphate synthetase-like proteins, one widely expressed (phosphoribosyl pyrophosphate synthetase 2) and one whose expression appears to be confined to the testis (phosphoribosyl pyrophosphate synthetase 1-like 1) (Taira et al. 1989; 1991). Neither of these proteins has been purified and characterized enzymatically, nor have variations in the abundance or sequence of either protein been associated with alterations in human nucleotide metabolism (Roessler et al. 1993; Becker et al. 1996), so their dimerization and ability to catalyze the synthesis of PRPP from D-ribose 5-phosphate are inferred here on the basis of their predicted amino acid sequence similarit…

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0Z361
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: C0Z361
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21212
feature: FragmentFeature6381
cellular location: GO_0005758
comment: Reactome DB_ID: 6248241
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C667
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
name: Q9C667
xref: UnificationXref21210
feature: FragmentFeature6380
cellular location: GO_0005758
comment: Reactome DB_ID: 6248240
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FNG7
data source: Provenance1
name: Q9FNG7
name: HSCB(1-235)
name: HSCB precursor
name: HSC20_HUMAN
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21219
feature: FragmentFeature6385
cellular location: GO_0005743
comment: Reactome DB_ID: 6248215
display name: HSCB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7K4
data source: Provenance1
name: HSCB(1-235)
name: HSCB precursor
name: HSC20_HUMAN
name: Q8L7K4
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21218
feature: FragmentFeature6384
cellular location: GO_0005743
comment: Reactome DB_ID: 6248214
display name: HSCB

Homologues of HSCB(1-235)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21220
cellular location: GO_0005743
comment: Reactome DB_ID: 6248216
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7B5
data source: Provenance1
name: Q8L7B5
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21208
feature: FragmentFeature6379
cellular location: GO_0005758
comment: Reactome DB_ID: 6248239
display name: HSPD1

UnificationXref18738
type: UnificationXref
id: Q9LUT0
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21238
data source: Provenance1
name: P21238
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21206
feature: FragmentFeature6378
cellular location: GO_0005758
comment: Reactome DB_ID: 6248238
display name: HSPD1

UnificationXref18739
type: UnificationXref
id: 6244570
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244570

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P29197
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
name: P29197
xref: UnificationXref21204
feature: FragmentFeature6377
cellular location: GO_0005758
comment: Reactome DB_ID: 6248237
display name: HSPD1

UnificationXref18736
type: UnificationXref
id: Q9LSE1
db: UniProt

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

UnificationXref18737
type: UnificationXref
id: 6244565
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244565

UnificationXref18746
type: UnificationXref
id: Q9LVG5
db: UniProt

UnificationXref18745
type: UnificationXref
id: 6244585
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244585

UnificationXref18744
type: UnificationXref
id: Q38979
db: UniProt

UnificationXref18743
type: UnificationXref
id: 6244580
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244580

UnificationXref18742
type: UnificationXref
id: Q84M95
db: UniProt

UnificationXref18741
type: UnificationXref
id: 6244575
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244575

UnificationXref18740
type: UnificationXref
id: Q8RWZ1
db: UniProt

Evidence978
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17222174
comment: Vitamin C (ascorbate) is an antioxidant and a cofactor in reactions catalyzed by Cu+-dependent monooxygenases and Fe++-dependent dioxygenases. Many mammals can synthesize ascorbate de novo; humans and other primates cannot due to an evolutionarily recent mutation in the gene catalyzing the last step of the biosynthetic pathway. Reactions annotated here mediate the uptake of ascorbate and its fully oxidized form, dehydroascorbate (DHA) by cells, and the reduction of DHA and monodehydroascorbate to regenerate ascorbate (Linster and Van Schaftingen 2007).

Evidence979
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11435118
xref: http://identifiers.org/pubmed/11342111
xref: http://identifiers.org/pubmed/11342117
comment: Cytosolic thiamin pyrophosphokinase (TPK1) catalyzes the reaction of thiamin (THMN) and ATP to form thiamin diphosphate (ThDP aka thiamin pyrophosphate) and ADP. ThDP is an active cofactor for transketolase, pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, enzymes involved in glycolysis and energy production. The gene encoding the human enzyme has been cloned and its protein product has been shown to have TPK1 activity (Nosaka et al. 2001; Zhao et al. 2001). Its homodomeric structure and association with Mg2+ are inferred from properties of the homologous yeast enzyme (Baker et al. 2001).

Evidence976
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7668255
xref: http://identifiers.org/pubmed/8513896
comment: Cytochrome b5 reductase (CYB5R3) catalyzes the reduction of cytosolic ferric CYB5A (CYB5A:ferriheme) to ferrous CYPB5A (CYB5A:heme), coupled to the conversion of NADH to NAD+ (Shirabe et al. 1995). CYB5R3 is associated with the outer mitochondrial membrane via a myristoyl group added post-translationally to glycine residue 2 of the protein (Borgese et al. 1993).

Evidence977
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15970797
xref: http://identifiers.org/pubmed/10783391
xref: http://identifiers.org/pubmed/16399380
comment: Cytosolic omega class glutathione transferases (GSTO1 and GSTO2) catalyze the reaction of dehydroascorbate (DHvitC) and glutathione (GSH) to form ascorbate (VitC) and oxidized glutathione (GSSG). The GSTO enzymes occur as homodimers (Board et al. 2000), and while both have dehydroascorbate reductase activity in vitro, that of GSTO2 is much greater than that of GSTO1 (Schmuck et al. 2005). Polymorphisms affecting the activities of the two enzymes have been described (Whitbread et al. 2005).

Evidence974
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11396616
xref: http://identifiers.org/pubmed/10556483
xref: http://identifiers.org/pubmed/10471399
xref: http://identifiers.org/pubmed/10556521
comment: The plasma membrane-associated transport proteins SVCT1 and SVCT2 are each capable of mediating the uptake of one molecule of ascorbate (VitC) and two sodium ions from the extracellular space to the cytosol (Daruwala et al. 1999; Rajan et al. 1999; Wang et al. 1999). In the body SVCT2 is expressed in most tissues, while SVCT1 is largely confined to epithelial cells (Liang et al. 2001). SVCT2 may mediate fetal uptake of ascorbate from the maternal circulation (Rajan et al. 1999). The transporters responsible for its uptake from the small intestine and for its release from enterocytes into the circulation have not been identified, although both SVCT1 and 2 are expressed in intestinal cells.

Evidence975
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7668255
xref: http://identifiers.org/pubmed/17222174
comment: The reduction of cytosolic semidehydroascorbate (SDA) to ascorbate (vitC) is catalyzed by cytochrome B5 (CYB5A) associated with the mitochondrial outer membrane. In the course of the reaction, the heme iron of the cytochrome is oxidized (Linster & Van Schaftingen 2007, Shirabe et al. 1995).

Evidence972
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12958597
xref: http://identifiers.org/pubmed/19469843
xref: http://identifiers.org/pubmed/9771710
xref: http://identifiers.org/pubmed/21552327
xref: http://identifiers.org/pubmed/21356517
xref: http://identifiers.org/pubmed/23913475
xref: http://identifiers.org/pubmed/9931343
xref: http://identifiers.org/pubmed/15930137
xref: http://identifiers.org/pubmed/20538597
xref: http://identifiers.org/pubmed/22248338
comment: Lafora disease is a progressive neurodegenerative disorder with onset typically late in childhood, characterized by seizures and progressive neurological deterioration and death within ten years of onset. Recessive mutations in EPM2A (laforin) and NHLRC1 (malin) have been identified as causes of the disease. The disease is classified here as one of glycogen storage as EPM2A (laforin) and NHLRC1 (malin) regulate normal glycogen turnover and defects in either protein are associated with the formation of Lafora bodies, accumulations of abnormal, insoluble glycogen molecules in tissues including brain, muscle, liver, and heart (Ramachandran et al. 2009; Roach et al. 2012). Consistent with a central role for glycogen accumulation in the disease, reduced (Turnbull et al. 2011) or absent (Pederson et al. 2013) glycogen synthase activity prevents Lafora Disease in mouse models. Type 2A disease. EPM2A (laforin) associated with cytosolic glycogen granules, normally catalyzes the removal of the phosphate groups added rarely but consistently to growing glycogen molecules (Tagliabracci et al. 2011). Defects in this catalytic activity lead to the formation of phosphorylated glycogen molecules that are insoluble and that show abnormal branching patterns (Minassian et al. 1998, Serratosa et al. 1999, Tagliabracci et al. 2011). Type 2B disease. NHLRC1 (malin) normally mediates polyubiquitination of EPM2A (laforin) and PPP1R3C (PTG). The two polyubiquitinated proteins are targeted for proteasome-mediated degradation, leaving a glycogen-glycogenin particle associated with glycogen synthase. In the absence of NHLRC1 activity, EPM2A and PPP1R3C proteins appear to persist, associated with the formation of abnormal, stable glycogen granules (Lafora bodies) (Chan et al. 2003; Gentry et al. 2005). In NHLRC1 knockout mice PPP1R3C levels are unchanged rather than increased, suggesting that NHLRC1 does not target PPP1R3C for degradation. However, EPM2A protein levels are increased in this knoc…

Evidence973
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19118303
xref: PublicationXref2029
comment: The regulated turnover of glycogen plays a central, tissue-specific role in the maintenance of blood glucose levels and in the provision of glucose to tissues such as muscle and brain in response to stress. Defects in the enzymes involved in glycogen turnover are associated with abnormal responses to fasting and exercise that can differ widely in their presentation and severity. Additional symptoms can be the result of accumulation of abnormal products of glycogen metabolism (www.ommbid.com). In this initial release, we have annotated two forms of myoclonic epilepsy of Lafora that are due to defects in proteins required for the turnover of the low levels of phosphoglycogen that accumulate in many tissues of the body. This module will be extended in future releases to cover diseases due to deficiencies in GYG1, the ubiquitously expressed form of glycogenin (GSD type XV), GYS2 and GYS1, the liver-specific and ubiquitously expressed forms of glycogen synthase (GSD type 0), GBE1, the single form of branching enzyme (GSD type IV), and in the endoplasmic reticulum-associated phosphatase (G6PC) and transporter (SLC37A4) required for export of glucose geneated by glycogen breakdown in liver (GSD type 1a and 1b, respectively). Severe congenital neutropenia type 4 (SCN4) is included in this group because its molecular basis is loss of glucose 6-phosphatase 3 (G6PC3) activity (Boztug et al. 2009). G6PC3 is a ubiquitously expressed isozyme of G6PC, the enzyme whose deficiency is the cause of glycogen storage disease type 1a (GSD 1a).

Evidence960
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9357955
comment: Cytosolic transketolase catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-xylulose 5-phosphate and D-ribose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

UnificationXref18747
type: UnificationXref
id: 6244590
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244590

UnificationXref18748
type: UnificationXref
id: A0MFG6
db: UniProt

UnificationXref18749
type: UnificationXref
id: 6244595
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244595

UnificationXref18755
type: UnificationXref
id: 6244610
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244610

UnificationXref18754
type: UnificationXref
id: Q6R2K1
db: UniProt

UnificationXref18757
type: UnificationXref
id: 6244613
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244613

UnificationXref18756
type: UnificationXref
id: F4J5Y7
db: UniProt

UnificationXref18751
type: UnificationXref
id: 6244600
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244600

Evidence969
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4328836
comment: Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

UnificationXref18750
type: UnificationXref
id: Q6R2K2
db: UniProt

UnificationXref18753
type: UnificationXref
id: 6244605
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244605

UnificationXref18752
type: UnificationXref
id: Q06BH3
db: UniProt

Evidence965
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14988808
comment: The reversible interconversion of ribulose 5-phosphate and ribose 5-phosphate is catalyzed by cytosolic ribose 5-phosphate isomerase (Huck et al. 2004).

Evidence966
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14988808
comment: The reversible interconversion of ribose 5-phosphate and ribulose 5-phosphate is catalyzed by cytosolic ribose 5-phosphate isomerase (Huck et al. 2004).

Evidence967
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18987987
xref: http://identifiers.org/pubmed/5666113
xref: http://identifiers.org/pubmed/3790084
comment: The pentose phosphate pathway is responsible for the generation of a substantial fraction of the cytoplasmic NADPH required for biosynthetic reactions, and for the generation of ribose 5-phosphate for nucleotide synthesis. Although the pentose phosphate pathway and glycolysis are distinct, they involve three common intermediates, glucose 6-phosphate, glyceraldehyde 3-phosphate, and fructose 6-phosphate, so the two pathways are interconnected. The pentose phosphate pathway consists of eight reactions:1. Conversion glucose 6-phosphate to D-glucono-1,5-lactone 6-phosphate, with the formation of NADPH; 2. Conversion of D-glucono-1,5-lactone 6-phosphate to 6-phospho-D-gluconate; 3. Conversion of 6-phospho-D-gluconate to ribulose 5-phosphate, with the formation of NADPH; 4. Conversion of ribulose 5-phosphate to xylulose 5-phosphate; 5. Conversion of ribulose 5-phosphate to ribose 5-phosphate; 6. Rearrangement of ribose 5-phosphate and xylulose 5-phosphate to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; 7. Rearrangement of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate; and 8. Rearrangement of xylulose 5-phosphate and erythrose 4-phosphate to form glyceraldehyde 3-phosphate and fructose-6-phosphate. The oxidative branch of the pentose phosphate pathway, reactions 1-3, generates NADPH and pentose 5-phosphate. The non-oxidative branch of the pathway, reactions 4-8, converts pentose 5-phosphate to other sugars. The overall pathway can operate to generate only NADPH (glucose 6-phosphate is converted to pentose 5-phosphates, which are directed to the synthesis of fructose 6-phosphate and glyceraldehyde 3-phosphate, which in turn are converted back to glucose 6-phosphate). The reactions of the non-oxidative branch can operate to generate net amounts of ribose 5-phosphate with no production of NADPH. Net flux through this network of reactions appears to depend on the metabolic state of the cell and…

Evidence968
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4328836
comment: Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyzes the reaction of D-ribose 5-phosphate and dATP to form 5-phospho-alpha-D-ribose 1-diphosphate and 2'-deoxyadenosine 5'-monophosphate. While phosphoribosyl pyrophosphate synthetase 1 works well with either ATP or dATP as a substrate in vitro, the extent of the dATP reaction in vivo is unclear, as cellular dATP concentrations are normally very low (Fox and Kelley 1971).

Evidence961
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8300619
xref: http://identifiers.org/pubmed/11283793
comment: Cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-erythrose 4-phosphate and D-fructose 6-phosphate. Protein expressed from the cloned gene has been characterized biochemically (Banki et al. 1994) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).

Evidence962
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8300619
xref: http://identifiers.org/pubmed/11283793
comment: Cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-erythrose 4-phosphate and D-fructose 6-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. Protein expressed from the cloned gene has been characterized biochemically (Banki et al. 1994) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).

Evidence963
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9357955
comment: Cytosolic transketolase catalyzes the reaction of D-erythrose 4-phosphate and D-xylulose 5-phosphate to form D-glyceraldehyde 3-phosphate and D-fructose 6-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

Evidence964
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9357955
comment: Cytosolic transketolase catalyzes the reaction of D-glyceraldehyde 3-phosphate and D-fructose 6-phosphate to form D-erythrose 4-phosphate and D-xylulose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

UnificationXref18759
type: UnificationXref
id: 6244618
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244618

UnificationXref18758
type: UnificationXref
id: Q9LRY1
db: UniProt

Evidence913
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10714828
xref: http://identifiers.org/pubmed/183598
xref: http://identifiers.org/pubmed/7144574
xref: PublicationXref1932
xref: http://identifiers.org/pubmed/18910717
xref: http://identifiers.org/pubmed/3170585
xref: http://identifiers.org/pubmed/2793178
comment: Cytosolic glyceraldehyde 3-phosphate dehydrogenase catalyzes the reversible reaction of glyceraldehyde 3-phosphate, orthophosphate, and NAD+ to form NADH + H+ and 1,3-bisphosphoglycerate, the first energy rich intermediate of glycolysis. The biochemical details of this reaction were worked out by C and G Cori and their colleagues (Taylor et al. 1948; Cori et al. 1948). While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989; Heinz and Freimuller 1982; Ercolani et al. 1988), and studies of aged human erythrocytes suggest that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

UnificationXref18760
type: UnificationXref
id: F4I7Q8
db: UniProt

Evidence912
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16511037
xref: http://identifiers.org/pubmed/6434534
comment: Cytosolic triose phosphate isomerase catalyzes the freely reversible interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (Lu et al. 1984). The active form of the enzyme is a homodimer (Kinoshita et al. 2005).

Evidence911
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6696436
xref: http://identifiers.org/pubmed/3355497
xref: http://identifiers.org/pubmed/7717389
comment: Cytosolic aldolase catalyzes the cleavage of D-fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. The active form of aldolase is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Freemont et al. 1984, 1988).

Evidence910
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7825568
xref: http://identifiers.org/pubmed/6444721
xref: http://identifiers.org/pubmed/6451249
xref: http://identifiers.org/pubmed/8117307
xref: http://identifiers.org/pubmed/2960695
comment: Cytosolic phosphofructokinase 1 catalyzes the reaction of fructose 6-phosphate and ATP to form fructose 1,6-bisphosphate and ADP. This reaction, irreversible under physiological conditions, is the rate limiting step of glycolysis. Phosphofructokinase 1 activity is allosterically regulated by ATP, citrate, and fructose 2,6-bisphosphate. Phosphofructokinase 1 is active as a tetramer (although higher order multimers, not annotated here, may form in vivo). Two isoforms of phosphofructokinase 1 monomer, L and M, are widely expressed in human tissues. Different tissues can contain different homotetramers or heterotetramers: L4 in liver, M4 in muscle, and all possible heterotetramers, L4, L3M, L2M2, LM3, and M4, in red blood cells, for example (Raben et al. 1995; Vora et al. 1980, 1987; Vora 1981). A third isoform, P, is abundant in platelets, where it is found in P4, P3L, P2L2, and PL3 tetramers (Eto et al. 1994; Vora et al. 1987).

UnificationXref18763
type: UnificationXref
id: 6244624
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244624

Evidence917
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3126495
xref: http://identifiers.org/pubmed/15982340
xref: http://identifiers.org/pubmed/15996096
xref: http://identifiers.org/pubmed/1896471
xref: http://identifiers.org/pubmed/2040271
xref: http://identifiers.org/pubmed/18191611
xref: http://identifiers.org/pubmed/11960989
comment: Cytosolic pyruvate kinase catalyzes the transfer of a high-energy phosphate from phosphoenolpyruvate to ADP, forming pyruvate and ATP. This reaction, an instance of substrate-level phosphorylation, is essentially irreversible under physiological conditions. Four isozymes of human pyruvate kinase have been described, L, R, M1 and M2. Isozymes L and R are encoded by alternatively spliced transcripts of the PKLR gene; isozymes M1 and M2 are encoded by alternatively spliced transcripts of PKM2. In the body, L pyruvate kinase is found in liver (Tani et al. 1988), R in red blood cells (Kanno et al. 1991), M1 in muscle, heart and brain (Takenaka et al. 1991), and M2 in early fetal tissues and tumors (e.g., Lee et al. 2008). In all cases, the active form of the enzyme is a homotetramer, activated by fructose 1,6-bisphosphate (Valentini et al. 2002; Dombrauckas et al. 2005). Mutations in PKLR have been associated with hemolytic anemias (e.g., Zanella et al. 2005).

UnificationXref18764
type: UnificationXref
id: Q1PEM1
db: UniProt

Evidence916
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2462567
xref: http://identifiers.org/pubmed/4413246
xref: http://identifiers.org/pubmed/3529090
xref: http://identifiers.org/pubmed/11506403
xref: http://identifiers.org/pubmed/3208766
comment: Cytosolic enolase catalyzes the reversible reaction of 2 phosphoglycerate to form phosphoenolpyruvate and water, elevating the transfer potential of the phosphoryl group. Enolase is a homodimer and requires Mg++ for activity. Three isozymes have been purified and biochemically characterized. The alpha isoform is expressed in many normal human tissues (Giallongo et al. 1986). The beta isoform is expressed in muscle. Evidence for its function in vivo in humans comes from studies of a patient in whom a point mutation in the gene encoding the enzyme was associated specifically with reduced enolase activity in muscle extracts and with other symptoms consistent with a defect in glycolysis (Comi et al. 2001). The gamma isoform of human enolase is normally expressed in neural tissue and is of possible clinical interest as a marker of some types of neuroendocrine and lung tumors (McAleese et al. 1988). Biochemical studies of the homologous rat proteins indicate that both homo- and heterodimers of enolase form and are enzymatically active (Rider and Taylor 1974).

UnificationXref18761
type: UnificationXref
id: 6244621
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244621

Evidence915
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8447317
xref: http://identifiers.org/pubmed/2846554
xref: http://identifiers.org/pubmed/4827367
xref: http://identifiers.org/pubmed/15710582
comment: Cytosolic phosphoglycerate mutase catalyzes the reversible isomerisation of 3- and 2-phosphoglycerate. The active form of the enzyme is a dimer. There are two isoforms of this enzyme, PGAM1 (isoform B, widely expressed in non-muscle tissue) and PGAM2 (isoform M, expressed in muscle) (Blouquit et al. 1988; Omenn and Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

UnificationXref18762
type: UnificationXref
id: Q9SVQ8
db: UniProt

Evidence914
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6771269
xref: http://identifiers.org/pubmed/7391027
xref: http://identifiers.org/pubmed/5009693
comment: Cytosolic phosphoglycerate kinase catalyzes the reaction of ADP and 1,3-bisphosphoglycerate to form D glyceraldehyde 3-phosphate and ATP. The active form of the enzyme is a monomer and requires Mg++ (Yoshida and Watanabe 1972; Huang et al. 1980a,b). This is the first substrate level phosphorylation reaction in glycolysis.

UnificationXref18767
type: UnificationXref
id: 6244632
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244632

UnificationXref18768
type: UnificationXref
id: Q9M8S2
db: UniProt

UnificationXref18765
type: UnificationXref
id: 6244627
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244627

Evidence919
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9792106
xref: http://identifiers.org/pubmed/16740313
comment: Mitochondrial malate dehydrogenase catalyzes the reversible reaction of oxaloacetate and NADH + H+ to form malate and NAD+ (Luo et al. 2006). Unpublished crystallographic data indicate that the protein is a dimer (PDB 3E04).

UnificationXref18766
type: UnificationXref
id: Q9LNH4
db: UniProt

Evidence918
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16051738
comment: The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate.

UnificationXref18769
type: UnificationXref
id: 6244637
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244637

UniProt:F4JRF4
type: ProteinReference
xref: UnificationXref21515
organism: http://identifiers.org/taxonomy/3702

Evidence900
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3897250
xref: http://identifiers.org/pubmed/12547908
xref: PublicationXref1896
comment: Maltotriose is representative of linear glucose oligomers containing more than two residues. The 1-4 linkages of extracellular maltotriose are hydrolyzed to yield maltose and glucose in a reaction catalyzed by the exoglucosidase activity of sucrase-isomaltase (Nichols et al. 1998; Semenza et al. 2001). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on maltotriose derived directly from the diet and from the hydrolysis of starch, although with lower activity than maltase-glucoamylase.

UnificationXref18770
type: UnificationXref
id: F4HYK7
db: UniProt

Evidence902
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3897250
xref: http://identifiers.org/pubmed/12547908
comment: The alpha-1,4 linkages of extracellular maltose are hydrolyzed to yield glucose in a reaction catalyzed by sucrase-maltase (Nichols et al. 1998; Semenza et al. 2001). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on maltose derived directly from the diet and from the hydrolysis of starch.

UnificationXref18771
type: UnificationXref
id: 6244642
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244642

Evidence901
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3897250
xref: http://identifiers.org/pubmed/12547908
comment: The alpha-1,4 linkages of extracellular maltose are hydrolyzed to yield glucose in a reaction catalyzed by maltase-glucoamylase (Nichols et al. 1998; Semenza et al. 2001). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985), and acts on maltose derived directly from the diet and from the hydrolysis of starch.

UnificationXref18772
type: UnificationXref
id: F4K946
db: UniProt

Evidence904
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/807575
xref: http://identifiers.org/pubmed/3800897
xref: http://identifiers.org/pubmed/3897250
comment: Extracellular sucrose is hydrolyzed to yield glucose and fructose in a reaction catalyzed by the sucrase domain of sucrase-isomaltase (Conklin et al. 1975). In the body, this enzyme is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). The sucrase-isomaltase polypeptide is cleaved into its sucrase and isomaltase domains, which remain associated and, by analogy to the corresponding pig enzyme, are thought to dimerize (Cowell et al. 1986).

UnificationXref18773
type: UnificationXref
id: 6244645
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244645

Evidence903
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12692040
xref: http://identifiers.org/pubmed/8951031
xref: http://identifiers.org/pubmed/7487100
xref: http://identifiers.org/pubmed/14616060
xref: http://identifiers.org/pubmed/3897250
comment: Extracellular lactose is hydrolyzed to yield molecules of glucose and galactose, in a reaction catalyzed by the lactase activity of lactase-phlorizin hydrolase associated with the plasma membrane. In the body, lactase-phlorzin hydrolase is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). Expression of the enzyme is developmentally regulated and subject to a genetic polymorphism: enzyme levels fall after weaning but the extent of the fall varies sharply between human populations (Grand et al. 2003; Swallow 2003). The lactase-phlorizin hydrolase polypeptide undergoes dimerization and two rounds of proteolytic cleavage in the course of its maturation and transport to the cell surface (Grunberg and Sterchi 1995; Wuthrich et al. 1996).

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

UnificationXref18774
type: UnificationXref
id: Q9LZ05
db: UniProt

Evidence906
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1896
comment: Carbohydrate is a major component of the human diet, and includes starch (amylose and amylopectin) and disaccharides such as sucrose, lactose, maltose and, in small amounts, trehalose. The digestion of starch begins with the action of amylase enzymes secreted in the saliva and small intestine, which convert it to maltotriose, maltose, limit dextrins, and some glucose. Digestion of the limit dextrins and disaccharides, both dietary and starch-derived, to monosaccharides - glucose, galactose, and fructose - is accomplished by enzymes located on the luminal surfaces of enterocytes lining the microvilli of the small intestine (Semenza et al. 2001).

UnificationXref18775
type: UnificationXref
id: 6244650
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244650

Evidence905
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6466686
xref: http://identifiers.org/pubmed/1697585
xref: http://identifiers.org/pubmed/9427547
comment: Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and the protein product of the clone has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.

UnificationXref18776
type: UnificationXref
id: Q9SIB6
db: UniProt

Evidence908
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'pPF2K-Pase complex' is present. At the end of this reaction, 1 molecule of 'Orthophosphate', and 1 molecule of 'PF2K-Pase1 homodimer' are present. This reaction takes place in the 'cytosol' and is mediated by the 'phosphatidate phosphatase activity' of 'PP2A-ABdeltaC complex'.

UnificationXref18777
type: UnificationXref
id: 6244653
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244653

Evidence907
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1907
xref: http://identifiers.org/pubmed/7989588
xref: http://identifiers.org/pubmed/13538944
xref: PublicationXref1908
xref: http://identifiers.org/pubmed/11371164
comment: Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

UnificationXref18778
type: UnificationXref
id: F4JEQ2
db: UniProt

UnificationXref18779
type: UnificationXref
id: 6244656
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244656

Evidence909
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15896703
xref: http://identifiers.org/pubmed/7574501
xref: http://identifiers.org/pubmed/10095107
xref: http://identifiers.org/pubmed/9464277
xref: http://identifiers.org/pubmed/2837207
xref: http://identifiers.org/pubmed/3052289
comment: The 6-phosphofructo-2-kinase activity of cytosolic PFKFB (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase) homodimer catalyzes the reaction of fructose 6-phosphate and ATP to form fructose 2,6-bisphosphate and ADP (Pilkis et al. 1988). Fructose 2,6-bisphosphate is not itself on the pathway of glycolysis. Rather, it acts as a positive allosteric effector of phosphofructokinase 1, greatly increasing the rate of synthesis of fructose 1,6-bisphosphate and hence the overall rate of glycolysis. The conversion of PFKFB between its dephosphorylated form, which catalyzes the synthesis of fructose 2,6-bisphosphate as described here, and its phosphorylated form, which catalyzes the hydrolysis of fructose 2,6-bisphosphate to fructose 6-phosphate and orthophosphate plays a central role in the short-term regulation of glycolysis (Pilkis et al. 1995). Four isoforms of PFKFB protein encoded by four different genes exhibit tissue-specific expression patterns. PFKFB1 is expressed in the liver (Algaier and Uyeda 1988), PFKFB2 is expressed in the heart (Hirata et al. 1998), PFKFB3 is ubiquitously expressed (Manes and el-Maghrabi 2005), and PFKFB4, originally described as a testis-specific gene product (Manzano et al. 1999), may also be expressed in several kinds of tumors.

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

http://identifiers.org/pubmed/59727
type: PublicationXref
id: 59727
author: Nachman, RL
author: Harpel, PC
db: Pubmed
title: Platelet alpha2-macroglobulin and alpha1-antitrypsin
source: J Biol Chem 251:4512-21
year: 1976

UnificationXref18781
type: UnificationXref
id: 6244661
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244661

Evidence935
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7902568
xref: http://identifiers.org/pubmed/17804405
xref: http://identifiers.org/pubmed/8257433
xref: http://identifiers.org/pubmed/1840235
comment: Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 6-phosphate to glucose 1-phosphate (Drago et al. 1991). Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.

UnificationXref18782
type: UnificationXref
id: Q9FE20
db: UniProt

Evidence934
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8379904
comment: The reactions of gluconeogenesis convert mitochondrial pyruvate to cytosolic glucose 6-phosphate which in turn can be hydrolyzed to glucose and exported from the cell. Gluconeogenesis is confined to cells of the liver and kidney and enables glucose synthesis from molecules such as lactate and alanine and other amino acids when exogenous glucose is not available (reviewed, e.g., by Gerich 1993). The process of gluconeogenesis as diagrammed below occurs in two parts: a network of reactions converts mitochondrial pyruvate to cytosolic phosphoenolpyruvate; then phosphoenolpyruvate is converted to glucose 6-phosphate in a single sequence of cytosolic reactions. Three variants of the first part of the process are physiologically important. 1) A series of transport and transamination reactions convert mitochondrial oxaloacetate to cytosolic oxaloacetate which is converted to phosphoenolpyruvate by a hormonally regulated, cytosolic isoform of phosphoenolpyruvate carboxykinase. This variant allows regulated glucose synthesis from lactate. 2) Mitochondrial oxaloacetate is reduced to malate, which is exported to the cytosol and re-oxidized to oxaloacetate. This variant provides reducing equivalents to the cytosol, needed for glucose synthesis from amino acids such as alanine and glutamine. 3) Constitutively expressed mitochondrial phosphoenolpyruvate carboxykinase catalyzes the conversion of mitochondrial oxaloacetate to phosphoenolpyruvate which is then transported to the cytosol. The exact path followed by any one molecule of pyruvate through this reaction network is determined by the tissue in which the reactions are occurring, the source of the pyruvate, and the physiological stress that triggered gluconeogenesis. In all cases, the synthesis of glucose from two molecules of pyruvate requires the generation and consumption of two reducing equivalents as cytosolic NADH + H+. For pyruvate derived from lactate (variants 1 and 3), NADH + H+ is generated with the oxidation of la…

Evidence933
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7989588
xref: http://identifiers.org/pubmed/13538944
xref: PublicationXref1908
comment: The reversible isomerization of fructose-6-phosphate to form glucose-6-phosphate is catalyzed by cytosolic phosphoglucose isomerase (Noltman 1972; Xu and Beutler 1994; Tsuboi et al. 1958).

UnificationXref18780
type: UnificationXref
id: Q8RWW0
db: UniProt

Evidence932
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7574501
comment: The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).

Evidence931
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9382095
xref: http://identifiers.org/pubmed/9678974
comment: Cytosolic fructose-1,6-bisphosphatase catalyzes the physiologically irreversible hydrolysis of fructose-1,6-bisphosphate to form fructose-6-phosphate and orthophosphate. In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).

Evidence930
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3355497
xref: http://identifiers.org/pubmed/7717389
comment: In this freely reversible cytosolic reaction, dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate react to form D-fructose 1,6-bisphosphate. The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).

UnificationXref18789
type: UnificationXref
id: 6244679
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244679

UnificationXref18787
type: UnificationXref
id: 6244674
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244674

UnificationXref18788
type: UnificationXref
id: Q1PDW3
db: UniProt

UnificationXref18785
type: UnificationXref
id: 6244671
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244671

Evidence939
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Cytosolic, non-phosphorylated PGYB dimers (b form) complexed with AMP can reversibly dissociate. This reaction is inferred from the AMP-binding properties of the closely homologous PGYM complex (Rath et al. 2000).

UnificationXref18786
type: UnificationXref
id: Q9LR92
db: UniProt

Evidence938
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2667896
xref: http://identifiers.org/pubmed/10949035
comment: Cytosolic, non-phosphorylated PGYB dimers (b form) can reversibly bind AMP. This reaction is inferred from the AMP-binding properties of human PGYL and closely homologous PGYM proteins from other species (Newgard et al. 1989; Rath et al. 2000).

UnificationXref18783
type: UnificationXref
id: 6244666
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244666

Evidence937
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18651836
xref: http://identifiers.org/pubmed/22248338
xref: http://identifiers.org/pubmed/9806880
comment: Glycogen, a highly branched glucose polymer, is formed and broken down in most human tissues, but is most abundant in liver and muscle, where it serves as a major stored fuel. Glycogen metabolism has been studied in most detail in muscle, although considerable experimental data are available concerning these reactions in liver as well. Glycogen metabolism in other tissues has not been studied as extensively, and is thought to resemble the muscle process. Glycogen synthesis involves five reactions. The first two, conversion of glucose 6-phosphate to glucose 1-phosphate and synthesis of UDP-glucose from glucose 1-phosphate and UTP, are shared with several other pathways. The next three reactions, the auto-catalyzed synthesis of a glucose oligomer on glycogenin, the linear extension of the glucose oligomer catalyzed by glycogen synthase, and the formation of branches catalyzed by glycogen branching enzyme, are unique to glycogen synthesis. Repetition of the last two reactions generates large, extensively branched glycogen polymers. The catalysis of glycogenin glucosylation and oligoglucose chain extension by distinct isozymes in liver and nonhepatic tissues allows them to be regulated independently (Agius 2008; Bollen et al. 1998; Roach et al. 2012).

UnificationXref18784
type: UnificationXref
id: Q9LVG6
db: UniProt

Evidence936
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8631325
xref: http://identifiers.org/pubmed/5427280
xref: http://identifiers.org/pubmed/5348606
comment: Cytosolic UDP-glucose pyrophosphorylase 2 (UGP2) catalyzes the reaction of UTP and glucose 1-phosphate to form UDP glucose and pyrophosphate (Knop and Hansen 1970; Duggleby et al. 1996). UGP2 is inferred to occur in the cell as a homooctamer from studies of its bovine homologue (Levine et al. 1969).

UniProt:F4JRD3
type: ProteinReference
xref: UnificationXref6828
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

UnificationXref18790
type: UnificationXref
id: Q9LQQ8
db: UniProt

Evidence922
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4687397
xref: http://identifiers.org/pubmed/8597574
xref: http://identifiers.org/pubmed/16920706
comment: The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

UnificationXref18791
type: UnificationXref
id: 6244684
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244684

Evidence921
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4052435
comment: Mitochondrial aspartate aminotransferase catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

UnificationXref18792
type: UnificationXref
id: P93749
db: UniProt

Evidence924
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8666394
xref: http://identifiers.org/pubmed/4719206
xref: http://identifiers.org/pubmed/11946196
xref: http://identifiers.org/pubmed/11945784
xref: http://identifiers.org/pubmed/9254007
comment: SLC25A1, in the inner mitochondrial membrane, mediates the exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate. The exchange is physiologically irreversible because of the potential of the inner mitochondrial membrane. The gene encoding human SLC25A1 has been cloned and its expression pattern has been characterized (Heisterkamp et al. 1995; Iacobazzi et al. 1997), but the biochemical details of the transport process are inferred from those worked out for the well-characterized rat system (Robinson 1971; Soling et al. 1971; Kleineke et al. 1973).

UnificationXref18793
type: UnificationXref
id: 6244689
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244689

Evidence923
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2241899
comment: Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer).

Evidence920
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2775751
xref: http://identifiers.org/pubmed/15565635
comment: Cytosolic malate dehydrogenase catalyzes the reaction of malate and NAD+ to form oxaloacetate and NADH + H+ (Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).

UnificationXref18798
type: UnificationXref
id: Q9SFT7
db: UniProt

UnificationXref18799
type: UnificationXref
id: 6244704
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244704

Evidence929
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8571957
xref: http://identifiers.org/pubmed/6434534
comment: The reversible conversion of glyceraldehyde-3-phosphate to dihydroxyacetone phosphate is catalyzed by cytosolic triose phosphate isomerase (Watanabe et al. 1996; Lu et al. 1984).

UnificationXref18794
type: UnificationXref
id: Q9C8M9
db: UniProt

Evidence926
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8447317
xref: http://identifiers.org/pubmed/15710582
comment: Cytosolic phosphoglycerate mutase dimer catalyzes the reversible isomerisation of 2- and 3-phosphoglycerate. There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Repiso et al. 2005; Tsujino et al. 1993).

UnificationXref18795
type: UnificationXref
id: 6244694
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244694

Evidence925
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2462567
xref: http://identifiers.org/pubmed/7689884
xref: http://identifiers.org/pubmed/3529090
xref: http://identifiers.org/pubmed/11506403
xref: http://identifiers.org/pubmed/3208766
comment: Cytosolic enolase dimer catalyzes the reversible reaction of phosphoenolpyruvate and water to form 2-phosphoglycerate. Three enolase isozymes have been purified and biochemically characterized. The alpha isoform is widely expressed (Giallongo et al. 1986). The beta isoform is expressed in muscle. Evidence for its function in vivo in humans comes from studies of a patient in whom a point mutation in the gene encoding the enzyme was associated specifically with reduced enolase activity in muscle extracts, and with other symptoms consistent with a defect in glycolysis (Comi et al. 2001). The gamma isoform of human enolase is normally expressed in neural tissue. It is not known to have distinctive biochemical functions, but is of possible clinical interest as a marker of some types of neuroendocrine and lung tumors (McAleese et al. 1988). Verma and Kurl (1993) identifed a possible fourth isoform, a "lung-specific" enolase whose expression is increased in response to dexamethasone treatment. The protein has not been biochemically characterized, however, nor have the levels of mRNA and protein in other tissues been examined. Thus, the observation that this protein is particularly similar in its predicted amino acid sequence to a duck crystallin (Wistow et al. 1988) raises the possibility that its normal function is unrelated to glycolysis.

UnificationXref18796
type: UnificationXref
id: Q9M1Q2
db: UniProt

Evidence928
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10714828
xref: http://identifiers.org/pubmed/183598
xref: http://identifiers.org/pubmed/7144574
xref: http://identifiers.org/pubmed/3170585
comment: The reversible reduction of 1,3-bisphosphoglycerate to form glyceraldehyde-3-phosphate is catalyzed by cytosolic glyceraldehyde-3-phosphate dehydrogenase tetramer. There are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, but only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

UnificationXref18797
type: UnificationXref
id: 6244699
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244699

Evidence927
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6771269
xref: http://identifiers.org/pubmed/7391027
comment: Cytosolic phosphoglycerate kinase complexed with magnesium catalyzes the reversible phosphorylation of 3-phosphoglycerate to form 1,3-bisphosphoglycerate (Huang et al. 1980a, 1980b).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LN27
data source: Provenance1
name: TI17A_HUMAN
name: TIMM17A
name: Mitochondrial import inner membrane translocase subunit Tim17-A
xref: UnificationXref21120
feature: FragmentFeature6334
cellular location: GO_0005743
comment: Reactome DB_ID: 6248027
display name: Q9LN27

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

ATP synthase beta chain precursor
type: Protein
entity reference: P19366
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21134
feature: FragmentFeature6340
cellular location: GO_0005758
comment: Reactome DB_ID: 6248249
display name: P19366

ATP synthase beta chain precursor
type: Protein
entity reference: P83483
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21132
feature: FragmentFeature6339
cellular location: GO_0005758
comment: Reactome DB_ID: 6248248
display name: P83483

Homologues of ATP5B(1-529)
type: Protein
data source: Provenance1
member physical entity: ATP synthase beta chain precursor
xref: UnificationXref21145
cellular location: GO_0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248255

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SP35
data source: Provenance1
name: TIMM17B
name: Mitochondrial import inner membrane translocase subunit Tim17-B
name: TI17B_HUMAN
xref: UnificationXref21126
feature: FragmentFeature6338
cellular location: GO_0005743
comment: Reactome DB_ID: 6248035
display name: Q9SP35

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LN27
data source: Provenance1
name: TIMM17B
name: Mitochondrial import inner membrane translocase subunit Tim17-B
name: TI17B_HUMAN
xref: UnificationXref21125
feature: FragmentFeature6337
cellular location: GO_0005743
comment: Reactome DB_ID: 6248034
display name: Q9LN27

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LYG1
data source: Provenance1
name: TIMM17B
name: Mitochondrial import inner membrane translocase subunit Tim17-B
name: TI17B_HUMAN
xref: UnificationXref21124
feature: FragmentFeature6336
cellular location: GO_0005743
comment: Reactome DB_ID: 6248033
display name: Q9LYG1

Homologues of TIMM17B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21127
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248036

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SP35
data source: Provenance1
name: TI17A_HUMAN
name: TIMM17A
name: Mitochondrial import inner membrane translocase subunit Tim17-A
xref: UnificationXref21122
feature: FragmentFeature6335
cellular location: GO_0005743
comment: Reactome DB_ID: 6248031
display name: Q9SP35

ATP synthase beta chain precursor
type: Protein
entity reference: Q42052
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21136
feature: FragmentFeature6341
cellular location: GO_0005758
comment: Reactome DB_ID: 6248250
display name: Q42052

ATP synthase beta chain precursor
type: Protein
entity reference: Q0WM57
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21138
feature: FragmentFeature6342
cellular location: GO_0005758
comment: Reactome DB_ID: 6248251
display name: Q0WM57

ATP synthase beta chain precursor
type: Protein
entity reference: Q9C5A9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21140
feature: FragmentFeature6343
cellular location: GO_0005758
comment: Reactome DB_ID: 6248252
display name: Q9C5A9

Homologues of ATP5B(1-529)
type: Protein
data source: Provenance1
member physical entity: ATP synthase beta chain precursor
xref: UnificationXref21159
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248167

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q94AX4
data source: Provenance1
name: LDHD(1-507)
name: Q94AX4
name: Probable D-lactate dehydrogenase, mitochondrial
name: LDHD precursor
name: LDHD_HUMAN
xref: UnificationXref21150
feature: FragmentFeature6348
cellular location: GO_0005758
comment: Reactome DB_ID: 6248258
display name: LDHD

ATP synthase beta chain precursor
type: Protein
entity reference: P19366
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21153
feature: FragmentFeature6350
cellular location: GO_0005743
comment: Reactome DB_ID: 6248152
display name: P19366

ATP synthase beta chain precursor
type: Protein
entity reference: P83483
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21152
feature: FragmentFeature6349
cellular location: GO_0005743
comment: Reactome DB_ID: 6248148
display name: P83483

ATP synthase beta chain precursor
type: Protein
entity reference: P83484
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21144
feature: FragmentFeature6345
cellular location: GO_0005758
comment: Reactome DB_ID: 6248254
display name: P83484

ATP synthase beta chain precursor
type: Protein
entity reference: Q8H135
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21142
feature: FragmentFeature6344
cellular location: GO_0005758
comment: Reactome DB_ID: 6248253
display name: Q8H135

UniProt:F4JRI7
type: ProteinReference
xref: UnificationXref19088
organism: http://identifiers.org/taxonomy/3702

Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
type: Protein
entity reference: Q93YP7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: COQ2(1-371)
name: COQ2 precursor
name: Q93YP7
name: COQ2_HUMAN
xref: UnificationXref21148
feature: FragmentFeature6347
cellular location: GO_0005758
comment: Reactome DB_ID: 6248257
display name: COQ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60112
data source: Provenance1
name: ATP5G1 precursor
name: ATP synthase proteolipid P1
name: ATPase sununit C
name: ATP synthase lipid-binding protein precursor
name: ATPase protein 9
name: ATP5G1(1-136)
xref: UnificationXref21147
feature: FragmentFeature6346
cellular location: GO_0005758
comment: Reactome DB_ID: 6248256
display name: P60112

http://identifiers.org/pubmed/16616430
type: PublicationXref
id: 16616430
author: Conti, F
author: Varoqui, H
author: Melone, M
author: Erickson, JD
db: Pubmed
title: Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex
source: Neuroscience 140:281-92
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C8X4
data source: Provenance1
name: Q9C8X4
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
xref: UnificationXref21089
feature: FragmentFeature6319
cellular location: GO_0005743
comment: Reactome DB_ID: 6248105
display name: GRPEL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LB47
data source: Provenance1
name: Q8LB47
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
xref: UnificationXref21087
feature: FragmentFeature6318
cellular location: GO_0005743
comment: Reactome DB_ID: 6248101
display name: GRPEL1

MyD88 dependent cascade initiated on endosome
type: Pathway
data source: Provenance1
pathway component: REACT 210244.2
evidence: Evidence1880
xref: UnificationXref19149
xref: UnificationXref19148
pathway order: PathwayStep1848
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9XQC7
data source: Provenance1
name: Q9XQC7
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
xref: UnificationXref21085
feature: FragmentFeature6317
cellular location: GO_0005743
comment: Reactome DB_ID: 6248097
display name: GRPEL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FLP3
data source: Provenance1
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
name: Q9FLP3
xref: UnificationXref21097
feature: FragmentFeature6323
cellular location: GO_0005743
comment: Reactome DB_ID: 6248115
display name: GRPEL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LA37
data source: Provenance1
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
name: Q8LA37
xref: UnificationXref21095
feature: FragmentFeature6322
cellular location: GO_0005743
comment: Reactome DB_ID: 6248113
display name: GRPEL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LDE9
data source: Provenance1
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
name: Q8LDE9
xref: UnificationXref21093
feature: FragmentFeature6321
cellular location: GO_0005743
comment: Reactome DB_ID: 6248111
display name: GRPEL1

Q9SZ18
type: Protein
entity reference: Q9SZ18
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
xref: UnificationXref21091
feature: FragmentFeature6320
cellular location: GO_0005743
comment: Reactome DB_ID: 6248107
display name: GRPEL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LB47
data source: Provenance1
name: Q8LB47
name: GRPE2_HUMAN
name: GrpE protein homolog 2, mitochondrial
xref: UnificationXref21101
feature: FragmentFeature6325
cellular location: GO_0005743
comment: Reactome DB_ID: 6248119
display name: GRPEL2

Homologues of GRPEL2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9SZ18
xref: UnificationXref21105
cellular location: GO_0005743
comment: Reactome DB_ID: 6248123
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q94K56
data source: Provenance1
name: Q94K56
name: GRPE1_HUMAN
name: GrpE protein homolog 1, mitochondrial
xref: UnificationXref21099
feature: FragmentFeature6324
cellular location: GO_0005743
comment: Reactome DB_ID: 6248117
display name: GRPEL1

UniProt:Q5XF59
type: ProteinReference
xref: UnificationXref16808
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/15526160
type: PublicationXref
id: 15526160
author: Rönnstrand, L
db: Pubmed
title: Signal transduction via the stem cell factor receptor/c-Kit
source: Cell Mol Life Sci 61:2535-48
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LDE9
data source: Provenance1
name: GRPE2_HUMAN
name: GrpE protein homolog 2, mitochondrial
name: Q8LDE9
xref: UnificationXref21103
feature: FragmentFeature6327
cellular location: GO_0005743
comment: Reactome DB_ID: 6248121
display name: GRPEL2

Q9SZ18
type: Protein
entity reference: Q9SZ18
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GRPE2_HUMAN
name: GrpE protein homolog 2, mitochondrial
xref: UnificationXref21102
feature: FragmentFeature6326
cellular location: GO_0005743
comment: Reactome DB_ID: 6248120
display name: GRPEL2

Homologues of DNAJC19
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21113
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248054

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FLP3
data source: Provenance1
name: GRPE2_HUMAN
name: GrpE protein homolog 2, mitochondrial
name: Q9FLP3
xref: UnificationXref21104
feature: FragmentFeature6328
cellular location: GO_0005743
comment: Reactome DB_ID: 6248122
display name: GRPEL2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LYY2
data source: Provenance1
name: Mitochondrial import inner membrane translocase subunit TIM14
name: TIM14_HUMAN
name: DNAJC19
name: DNAJC19 (TIM14) (PAM18)
xref: UnificationXref21110
feature: FragmentFeature6330
cellular location: GO_0005743
comment: Reactome DB_ID: 6248049
display name: Q9LYY2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SF33
data source: Provenance1
name: Mitochondrial import inner membrane translocase subunit TIM14
name: TIM14_HUMAN
name: DNAJC19
name: DNAJC19 (TIM14) (PAM18)
xref: UnificationXref21108
feature: FragmentFeature6329
cellular location: GO_0005743
comment: Reactome DB_ID: 6248045
display name: Q9SF33

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VYE2
data source: Provenance1
name: TIM50_HUMAN
name: Mitochondrial import inner membrane translocase subunit TIM50
name: Q8VYE2
xref: UnificationXref21116
feature: FragmentFeature6332
cellular location: GO_0005743
comment: Reactome DB_ID: 6248018
display name: TIMM50

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8RV04
data source: Provenance1
name: Mitochondrial import inner membrane translocase subunit TIM14
name: TIM14_HUMAN
name: DNAJC19
name: DNAJC19 (TIM14) (PAM18)
xref: UnificationXref21112
feature: FragmentFeature6331
cellular location: GO_0005743
comment: Reactome DB_ID: 6248053
display name: Q8RV04

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LYG1
data source: Provenance1
name: TI17A_HUMAN
name: TIMM17A
name: Mitochondrial import inner membrane translocase subunit Tim17-A
xref: UnificationXref21118
feature: FragmentFeature6333
cellular location: GO_0005743
comment: Reactome DB_ID: 6248023
display name: Q9LYG1

Homologues of TIMM17A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21123
cellular location: GO_0005743
comment: Reactome DB_ID: 6248032
comment: Converted from EntitySet in Reactome

Homologues of PAM16
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21074
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248067

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q5XF06
data source: Provenance1
name: TIM44_HUMAN
name: Mitochondrial import inner membrane translocase subunit TIM44
name: TIMM44(?-452)
name: Q5XF06
xref: UnificationXref21062
feature: FragmentFeature6307
cellular location: GO_0005743
comment: Reactome DB_ID: 6248071
display name: TIMM44

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1PF33
data source: Provenance1
name: TIM44_HUMAN
name: Mitochondrial import inner membrane translocase subunit TIM44
name: TIMM44(?-452)
name: Q1PF33
xref: UnificationXref21064
feature: FragmentFeature6308
cellular location: GO_0005743
comment: Reactome DB_ID: 6248075
display name: TIMM44

(Indol-3-yl)pyruvate
type: SmallMoleculeReference
name: ChEBI:29750 3-(indol-3-yl)pyruvic acid
name: Indolepyruvic acid
name: 3-(Indol-3-yl)pyruvate
name: Indole-3-pyruvate
name: Indolepyruvate
name: 3-(indol-3-yl)pyruvic acid
xref: UnificationXref16892

Q1G3L1
type: Protein
entity reference: Q1G3L1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: C18orf55 (TIM21L)
name: TIM21-like protein, mitochondrial
name: TI21L_HUMAN
name: C18orf55
xref: UnificationXref21060
feature: FragmentFeature6306
cellular location: GO_0005743
comment: Reactome DB_ID: 6248041
display name: TIMM21

RNA Polymerase II Transcription Elongation
type: Pathway
data source: Provenance1
pathway component: Formation of the Early Elongation Complex
pathway component: REACT 246864.1
evidence: Evidence503
xref: RelationshipXref228
xref: UnificationXref6252
xref: UnificationXref6251
pathway order: PathwayStep480
pathway order: PathwayStep482
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Homologues of TIMM44(?-452)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21065
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248076

Small ubiquitin-related modifier 2
type: Protein
entity reference: P55852
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBE2I-G93-SUMO2
name: SUMO2_HUMAN
xref: UnificationXref21042
feature: FragmentFeature6304
feature: ModificationFeature609
cellular location: GO_0005654
comment: Reactome DB_ID: 6252556
display name: P55852

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q9FLP6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBE2I-G93-SUMO2
name: SUMO2_HUMAN
xref: UnificationXref21043
feature: FragmentFeature6305
feature: ModificationFeature610
cellular location: GO_0005654
comment: Reactome DB_ID: 6252558
display name: Q9FLP6

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q8VZI7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBE2I-G93-SUMO2
name: SUMO2_HUMAN
xref: UnificationXref21040
feature: FragmentFeature6302
feature: ModificationFeature607
cellular location: GO_0005654
comment: Reactome DB_ID: 6252552
display name: Q8VZI7

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q9FLP5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBE2I-G93-SUMO2
name: SUMO2_HUMAN
xref: UnificationXref21041
feature: FragmentFeature6303
feature: ModificationFeature608
cellular location: GO_0005654
comment: Reactome DB_ID: 6252554
display name: Q9FLP5

Small ubiquitin-related modifier 2
type: Protein
entity reference: B3H5R8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBE2I-G93-SUMO2
name: SUMO2_HUMAN
xref: UnificationXref21039
feature: ModificationFeature606
feature: FragmentFeature6301
cellular location: GO_0005654
comment: Reactome DB_ID: 6252550
display name: B3H5R8

Stress-70 protein, mitochondrial
type: Protein
entity reference: Q9STW6
data source: Provenance1
name: HSPA9 (mtHsp70)
name: Q9STW6
name: Note: the coordinates are copied over from Homo sapiens.
name: GRP75_HUMAN
xref: UnificationXref21078
feature: FragmentFeature6314
cellular location: GO_0005743
comment: Reactome DB_ID: 6248084
display name: HSPA9

Stress-70 protein, mitochondrial
type: Protein
entity reference: Q8GUM2
data source: Provenance1
name: HSPA9 (mtHsp70)
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8GUM2
name: GRP75_HUMAN
xref: UnificationXref21080
feature: FragmentFeature6315
cellular location: GO_0005743
comment: Reactome DB_ID: 6248088
display name: HSPA9

Stress-70 protein, mitochondrial
type: Protein
entity reference: Q9LTX9
data source: Provenance1
name: HSPA9 (mtHsp70)
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9LTX9
name: GRP75_HUMAN
xref: UnificationXref21082
feature: FragmentFeature6316
cellular location: GO_0005743
comment: Reactome DB_ID: 6248092
display name: HSPA9

http://identifiers.org/pubmed/17035228
type: PublicationXref
id: 17035228
author: Ron, D
author: Zilpa, T
author: Shabtay, A
author: Dym, N
author: Preger, E
author: Ziv, I
author: Harduf, H
author: Fuchs, Y
db: Pubmed
title: The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate
source: J Biol Chem 281:39225-35
year: 2006

Homologues of GRPEL1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9SZ18
xref: UnificationXref21100
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248118

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LX43
data source: Provenance1
name: TIM16_HUMAN
name: PAM16 (TIM16)
name: Q9LX43
name: Mitochondrial import inner membrane translocase subunit TIM16
xref: UnificationXref21071
feature: FragmentFeature6311
cellular location: GO_0005743
comment: Reactome DB_ID: 6248064
display name: PAM16

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93VV9
data source: Provenance1
name: TIM16_HUMAN
name: PAM16 (TIM16)
name: Q93VV9
name: Mitochondrial import inner membrane translocase subunit TIM16
xref: UnificationXref21073
feature: FragmentFeature6312
cellular location: GO_0005743
comment: Reactome DB_ID: 6248066
display name: PAM16

Homologues of HSPA9
type: Protein
data source: Provenance1
member physical entity: Stress-70 protein, mitochondrial
xref: UnificationXref21083
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248093

Stress-70 protein, mitochondrial
type: Protein
entity reference: Q9LDZ0
data source: Provenance1
name: HSPA9 (mtHsp70)
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9LDZ0
name: GRP75_HUMAN
xref: UnificationXref21076
feature: FragmentFeature6313
cellular location: GO_0005743
comment: Reactome DB_ID: 6248080
display name: HSPA9

http://identifiers.org/pubmed/10496324
type: PublicationXref
id: 10496324
author: Dharmawardhane, S
author: Lennartz, M
author: Bokoch, GM
author: Brownson, D
db: Pubmed
title: Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
source: J Leukoc Biol 66:521-7
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FLS3
data source: Provenance1
name: TIM16_HUMAN
name: PAM16 (TIM16)
name: Mitochondrial import inner membrane translocase subunit TIM16
name: Q9FLS3
xref: UnificationXref21067
feature: FragmentFeature6309
cellular location: GO_0005743
comment: Reactome DB_ID: 6248058
display name: PAM16

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93W66
data source: Provenance1
name: TIM16_HUMAN
name: PAM16 (TIM16)
name: Q93W66
name: Mitochondrial import inner membrane translocase subunit TIM16
xref: UnificationXref21069
feature: FragmentFeature6310
cellular location: GO_0005743
comment: Reactome DB_ID: 6248060
display name: PAM16

UniProt:Q5XEY4
type: ProteinReference
xref: UnificationXref2175
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

http://identifiers.org/pubmed/9741684
type: PublicationXref
id: 9741684
author: Edwards, PA
author: Shell, BK
author: Greene, JM
author: Ericsson, J
author: Carter, KC
author: Florence, C
author: Duan, DR
db: Pubmed
title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
source: J Lipid Res 39:1731-9
year: 1998

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FLP5
data source: Provenance1
name: Small ubiquitin-related modifier 3
name: SUMO3_HUMAN
name: UBA2-G92-SUMO3
xref: UnificationXref21023
feature: FragmentFeature6296
feature: ModificationFeature602
cellular location: GO_0005654
comment: Reactome DB_ID: 6252519
display name: Q9FLP5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P55852
data source: Provenance1
name: Small ubiquitin-related modifier 3
name: SUMO3_HUMAN
name: UBA2-G92-SUMO3
xref: UnificationXref21024
feature: ModificationFeature603
feature: FragmentFeature6297
cellular location: GO_0005654
comment: Reactome DB_ID: 6252521
display name: P55852

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FLP6
data source: Provenance1
name: Small ubiquitin-related modifier 3
name: SUMO3_HUMAN
name: UBA2-G92-SUMO3
xref: UnificationXref21025
feature: ModificationFeature604
feature: FragmentFeature6298
cellular location: GO_0005654
comment: Reactome DB_ID: 6252523
display name: Q9FLP6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q42551
data source: Provenance1
name: Q42551
name: SUMO-conjugating enzyme UBC9
name: UBC9_HUMAN
name: UBE2I (UBC9)
xref: UnificationXref21034
feature: FragmentFeature6299
cellular location: GO_0005654
comment: Reactome DB_ID: 6252517
display name: UBE2I

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q42551
data source: Provenance1
name: SUMO-conjugating enzyme UBC9
name: SUMO3 S-glycyl-cys93 UBE2I
name: SUMO3-C93-UBE2I
name: UBC9_HUMAN
xref: UnificationXref21035
feature: ModificationFeature605
feature: FragmentFeature6300
cellular location: GO_0005654
comment: Reactome DB_ID: 6252528
display name: Q42551

Homologues of UBE2I-G93-SUMO2
type: Protein
data source: Provenance1
member physical entity: Small ubiquitin-related modifier 2
xref: UnificationXref21044
cellular location: GO_0005654
comment: Reactome DB_ID: 6252559
comment: Converted from EntitySet in Reactome

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q9FLP5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SUMO2_HUMAN
name: UBA2-G93-SUMO2
xref: UnificationXref21015
feature: ModificationFeature599
feature: FragmentFeature6293
cellular location: GO_0005654
comment: Reactome DB_ID: 6252540
display name: Q9FLP5

Small ubiquitin-related modifier 2
type: Protein
entity reference: P55852
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SUMO2_HUMAN
name: UBA2-G93-SUMO2
xref: UnificationXref21016
feature: FragmentFeature6294
feature: ModificationFeature600
cellular location: GO_0005654
comment: Reactome DB_ID: 6252542
display name: P55852

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q9FLP6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SUMO2_HUMAN
name: UBA2-G93-SUMO2
xref: UnificationXref21017
feature: FragmentFeature6295
feature: ModificationFeature601
cellular location: GO_0005654
comment: Reactome DB_ID: 6252544
display name: Q9FLP6

Homologues of UBA2-G92-SUMO3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21026
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6252524

http://identifiers.org/pubmed/10101268
type: PublicationXref
id: 10101268
author: Heilmeyer LM, Jr
author: Gehrmann, T
author: Balla, A
author: Herberg, FW
author: Mayr, Georg W
author: Suer, S
author: Gülkan, H
author: Vereb, G
db: Pubmed
title: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230
source: Biochim Biophys Acta 1437:341-56
year: 1999

http://identifiers.org/pubmed/10615129
type: PublicationXref
id: 10615129
author: Mauro, T
author: Ikeda, S
author: Bonifas, JM
author: Beech, J
author: Bench, G
author: Ogawa, H
author: Hu, Z
author: Shigihara, T
author: Epstein EH, Jr
db: Pubmed
title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
source: Nat Genet 24:61-5
year: 2000

http://identifiers.org/pubmed/15175005
type: PublicationXref
id: 15175005
author: Stewart, AJ
author: Sadler, PJ
author: Roberts, SJ
author: Farquharson, C
db: Pubmed
title: Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities
source: Biochem J 382:59-65
year: 2004

http://identifiers.org/pubmed/11322953
type: PublicationXref
id: 11322953
author: Ishida, N
author: Kawakita, M
author: Muraoka, M
db: Pubmed
title: Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
source: FEBS Lett 495:87-93
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21240
data source: Provenance1
name: P21240
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21202
feature: FragmentFeature6376
cellular location: GO_0005758
comment: Reactome DB_ID: 6248236
display name: HSPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FNG7
data source: Provenance1
name: Q9FNG7
name: HSCB(1-235)
name: HSCB precursor
name: HSC20_HUMAN
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21195
feature: FragmentFeature6373
cellular location: GO_0005758
comment: Reactome DB_ID: 6248232
display name: HSCB

Homologues of HSPD1(1-573)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9LJE4
xref: UnificationXref21215
cellular location: GO_0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248243

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93ZM7
data source: Provenance1
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: Q93ZM7
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21198
feature: FragmentFeature6374
cellular location: GO_0005758
comment: Reactome DB_ID: 6248234
display name: HSPD1

Q9LJE4
type: Protein
entity reference: Q9LJE4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 60 kDa heat shock protein, mitochondrial
name: HSPD1(1-573)
name: HSP60 precursor
name: CH60_HUMAN
xref: UnificationXref21200
feature: FragmentFeature6375
cellular location: GO_0005758
comment: Reactome DB_ID: 6248235
display name: HSPD1

phagocytic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref9852

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZR07
data source: Provenance1
name: FRDA_HUMAN
name: FXN(1-210)
name: Frataxin precursor
name: Q9ZR07
xref: UnificationXref21191
feature: FragmentFeature6371
cellular location: GO_0005758
comment: Reactome DB_ID: 6248230
display name: FXN

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q42290
data source: Provenance1
name: Mitochondrial-processing peptidase subunit beta
name: Q42290
name: MPPB_HUMAN
xref: UnificationXref21185
feature: FragmentFeature6370
cellular location: GO_0005759
comment: Reactome DB_ID: 6248209
display name: PMPCB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L7K4
data source: Provenance1
name: HSCB(1-235)
name: HSCB precursor
name: HSC20_HUMAN
name: Q8L7K4
name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
xref: UnificationXref21193
feature: FragmentFeature6372
cellular location: GO_0005758
comment: Reactome DB_ID: 6248231
display name: HSCB

Homologues of HSCB(1-235)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21196
cellular location: GO_0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248233

synaptic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref191

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O04308
data source: Provenance1
name: Mitochondrial-processing peptidase subunit alpha
name: O04308
name: MPPA_HUMAN
xref: UnificationXref21182
feature: FragmentFeature6369
cellular location: GO_0005759
comment: Reactome DB_ID: 6248204
display name: PMPCA

UniProt:F4K456
type: ProteinReference
xref: UnificationXref6826
organism: http://identifiers.org/taxonomy/3702

UniProt:F4K455
type: ProteinReference
xref: UnificationXref6820
organism: http://identifiers.org/taxonomy/3702

secretory granule membrane
type: CellularLocationVocabulary
xref: UnificationXref9085

Golgi-associated vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref4759

http://identifiers.org/pubmed/11459976
type: PublicationXref
id: 11459976
author: Bell, SP
author: Klemm, RD
db: Pubmed
title: ATP bound to the origin recognition complex is important for preRC formation.
source: Proc Natl Acad Sci U S A 98:8361-7
year: 2001

ATP synthase beta chain precursor
type: Protein
entity reference: Q8H135
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21157
feature: FragmentFeature6354
cellular location: GO_0005743
comment: Reactome DB_ID: 6248164
display name: Q8H135

ATP synthase beta chain precursor
type: Protein
entity reference: P83484
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21158
feature: FragmentFeature6355
cellular location: GO_0005743
comment: Reactome DB_ID: 6248166
display name: P83484

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60112
data source: Provenance1
name: ATP5G1 precursor
name: ATP synthase proteolipid P1
name: ATPase sununit C
name: ATP synthase lipid-binding protein precursor
name: ATPase protein 9
name: ATP5G1(1-136)
xref: UnificationXref21160
feature: FragmentFeature6356
cellular location: GO_0005743
comment: Reactome DB_ID: 6248173
display name: P60112

Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
type: Protein
entity reference: Q93YP7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: COQ2(1-371)
name: COQ2 precursor
name: Q93YP7
name: COQ2_HUMAN
xref: UnificationXref21161
feature: FragmentFeature6357
cellular location: GO_0005743
comment: Reactome DB_ID: 6248177
display name: COQ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q94AX4
data source: Provenance1
name: LDHD(1-507)
name: Q94AX4
name: Probable D-lactate dehydrogenase, mitochondrial
name: LDHD precursor
name: LDHD_HUMAN
xref: UnificationXref21162
feature: FragmentFeature6358
cellular location: GO_0005743
comment: Reactome DB_ID: 6248181
display name: LDHD

Homologues of ATP5B
type: Protein
data source: Provenance1
member physical entity: Q9C5A9
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P83484
member physical entity: P83483
xref: UnificationXref21174
cellular location: GO_0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248191

P83483
type: Protein
entity reference: P83483
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
xref: UnificationXref21167
feature: FragmentFeature6359
cellular location: GO_0005743
comment: Reactome DB_ID: 6248184
display name: ATP5B

ATP synthase beta chain precursor
type: Protein
entity reference: Q42052
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21154
feature: FragmentFeature6351
cellular location: GO_0005743
comment: Reactome DB_ID: 6248156
display name: Q42052

ATP synthase beta chain precursor
type: Protein
entity reference: Q9C5A9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21156
feature: FragmentFeature6353
cellular location: GO_0005743
comment: Reactome DB_ID: 6248162
display name: Q9C5A9

ATP synthase beta chain precursor
type: Protein
entity reference: Q0WM57
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase subunit beta, mitochondrial
name: ATP5B precursor
name: ATP5B(1-529)
xref: UnificationXref21155
feature: FragmentFeature6352
cellular location: GO_0005743
comment: Reactome DB_ID: 6248158
display name: Q0WM57

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60112
data source: Provenance1
name: P60112
name: ATP synthase proteolipid P1
name: ATPase sununit C
name: ATPase protein 9
name: ATP synthase lipid-binding protein
xref: UnificationXref21175
feature: FragmentFeature6366
cellular location: GO_0005743
comment: Reactome DB_ID: 6248192
display name: ATP5G1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q94AX4
data source: Provenance1
name: Q94AX4
name: Probable D-lactate dehydrogenase, mitochondrial
name: LDHD_HUMAN
name: LDHD(18-507)
xref: UnificationXref21176
feature: FragmentFeature6367
cellular location: GO_0005743
comment: Reactome DB_ID: 6248194
display name: LDHD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8H135
data source: Provenance1
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
name: Q8H135
xref: UnificationXref21172
feature: FragmentFeature6364
cellular location: GO_0005743
comment: Reactome DB_ID: 6248189
display name: ATP5B

P83484
type: Protein
entity reference: P83484
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
xref: UnificationXref21173
feature: FragmentFeature6365
cellular location: GO_0005743
comment: Reactome DB_ID: 6248190
display name: ATP5B

Homologues of PMPCA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21183
cellular location: GO_0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6248205

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZU25
data source: Provenance1
name: Mitochondrial-processing peptidase subunit alpha
name: MPPA_HUMAN
name: Q9ZU25
xref: UnificationXref21180
feature: FragmentFeature6368
cellular location: GO_0005759
comment: Reactome DB_ID: 6248200
display name: PMPCA

Q9C5A9
type: Protein
entity reference: Q9C5A9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
xref: UnificationXref21171
feature: FragmentFeature6363
cellular location: GO_0005743
comment: Reactome DB_ID: 6248188
display name: ATP5B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0WM57
data source: Provenance1
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
name: Q0WM57
xref: UnificationXref21170
feature: FragmentFeature6362
cellular location: GO_0005743
comment: Reactome DB_ID: 6248187
display name: ATP5B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q42052
data source: Provenance1
name: Q42052
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
xref: UnificationXref21169
feature: FragmentFeature6361
cellular location: GO_0005743
comment: Reactome DB_ID: 6248186
display name: ATP5B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P19366
data source: Provenance1
name: P19366
name: ATP synthase beta chain
name: ATP synthase subunit beta, mitochondrial
xref: UnificationXref21168
feature: FragmentFeature6360
cellular location: GO_0005743
comment: Reactome DB_ID: 6248185
display name: ATP5B

http://identifiers.org/pubmed/22178396
type: PublicationXref
id: 22178396
author: Anderton, Emma
author: Shinkai, Y
author: Kuninaka, Shinji
author: Saya, H
author: Imai, Yoshinori
author: Peters, Gordon
author: Hara, Eiji
author: Yamakoshi, Kimi
author: Yoshimoto, Shin
author: Takeuchi, Takashi
author: Ohtani, Naoko
author: Takahashi, Akiko
author: Hori, Satoshi
author: Tachibana, M
db: Pubmed
title: DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
source: Mol. Cell 45:123-31
year: 2012

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

http://identifiers.org/pubmed/11459989
type: PublicationXref
id: 11459989
author: Paulusma, C
author: Wyman, C
author: Kanaar, R
author: Ristic, D
db: Pubmed
title: The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.
source: Proc Natl Acad Sci U S A 98:8454-60
year: 2001

UniProt:F4K3X8
type: ProteinReference
xref: UnificationXref2227
organism: http://identifiers.org/taxonomy/3702

(1R-cis)-2-amino-1,9-dihydro-9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one
type: SmallMoleculeReference
name: (-)-carbovir
name: carbovir
name: CBV
name: 2-amino-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-9H-purin-6-ol
name: (-)-carbovir [ChEBI:421843]
xref: UnificationXref18483

UniProt:B2C6R6
type: ProteinReference
xref: UnificationXref6071
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/9856482
type: PublicationXref
id: 9856482
author: Schnetkamp, PP
author: Tucker, JE
author: Walter, MA
author: Friedman, JS
author: Winkfein, RJ
author: Murthy, SK
author: Demetrick, DJ
db: Pubmed
title: Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger
source: Hum Genet 103:411-4
year: 1998

http://identifiers.org/pubmed/7506871
type: PublicationXref
id: 7506871
author: Hübner, S
author: Appelhans, H
author: Wagner, S
author: Drenckhahn, D
author: Kollert-Jöns, A
db: Pubmed
title: Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
source: Am J Physiol 265:F813-21
year: 1993

http://identifiers.org/pubmed/19373259
type: PublicationXref
id: 19373259
author: Pauli, Silke
author: Koch, HG
author: Linnebank, Michael
author: Häberle, Johannes
author: Berning, Christoph
db: Pubmed
title: TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations
source: J. Hum. Genet. 54:331-4
year: 2009

http://identifiers.org/pubmed/20198122
type: PublicationXref
id: 20198122
author: La Cava, Antonio
author: Matarese, Giuseppe
author: Lam, Queenie Lai Kwan
author: Lu, Liwei
author: Iikuni, Noriko
db: Pubmed
title: Leptin and Inflammation
source: Curr Immunol Rev 4:70-79
year: 2008

http://identifiers.org/pubmed/18022816
type: PublicationXref
id: 18022816
author: Garcia, S
author: López-Colomé, AM
author: López, E
db: Pubmed
title: Glutamate accelerates RPE cell proliferation through ERK1/2 activation via distinct receptor-specific mechanisms
source: J Cell Biochem 104:377-90
year: 2008

transport vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref8447

cytoplasmic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref4861

UnificationXref18820
type: UnificationXref
id: Q9LDZ5
db: UniProt

UnificationXref18821
type: UnificationXref
id: 6244749
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244749

UnificationXref18822
type: UnificationXref
id: Q0V7T5
db: UniProt

UnificationXref18823
type: UnificationXref
id: 6244754
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244754

UnificationXref18818
type: UnificationXref
id: A0MF69
db: UniProt

UnificationXref18817
type: UnificationXref
id: 6244743
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244743

UnificationXref18819
type: UnificationXref
id: 6244746
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244746

UnificationXref18814
type: UnificationXref
id: O04245
db: UniProt

UnificationXref18813
type: UnificationXref
id: 6244735
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244735

UnificationXref18816
type: UnificationXref
id: B9DFG5
db: UniProt

UnificationXref18815
type: UnificationXref
id: 6244738
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244738

UnificationXref18833
type: UnificationXref
id: 6244777
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244777

UnificationXref18834
type: UnificationXref
id: F4JTH2
db: UniProt

UnificationXref18831
type: UnificationXref
id: 6244772
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244772

UnificationXref18832
type: UnificationXref
id: Q84WC3
db: UniProt

UnificationXref18830
type: UnificationXref
id: F4IRL7
db: UniProt

UnificationXref18829
type: UnificationXref
id: 6244767
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244767

UnificationXref18828
type: UnificationXref
id: P93036
db: UniProt

UnificationXref18827
type: UnificationXref
id: 6244764
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244764

UnificationXref18826
type: UnificationXref
id: Q8H1G6
db: UniProt

UnificationXref18825
type: UnificationXref
id: 6244759
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244759

UnificationXref18824
type: UnificationXref
id: F4HWU0
db: UniProt

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

UnificationXref18800
type: UnificationXref
id: Q8GYQ4
db: UniProt

UnificationXref18801
type: UnificationXref
id: 6244707
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244707

CDK-mediated phosphorylation and removal of Cdc6
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction124
pathway component: BiochemicalReaction126
pathway component: BiochemicalReaction125
evidence: Evidence203
xref: UnificationXref3410
xref: UnificationXref3411
pathway order: PathwayStep193
pathway order: PathwayStep192
pathway order: PathwayStep191
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UnificationXref18811
type: UnificationXref
id: 6244730
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244730

UnificationXref18812
type: UnificationXref
id: O49339
db: UniProt

UnificationXref18810
type: UnificationXref
id: F4HX16
db: UniProt

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

UnificationXref18805
type: UnificationXref
id: 6244717
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244717

UnificationXref18804
type: UnificationXref
id: Q9FG24
db: UniProt

UnificationXref18803
type: UnificationXref
id: 6244712
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244712

UnificationXref18802
type: UnificationXref
id: Q67YK2
db: UniProt

UnificationXref18809
type: UnificationXref
id: 6244725
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244725

UnificationXref18808
type: UnificationXref
id: Q8L7V7
db: UniProt

UnificationXref18807
type: UnificationXref
id: 6244720
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244720

UnificationXref18806
type: UnificationXref
id: Q9LJU5
db: UniProt

SequenceSite12010
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite12012
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12011
type: SequenceSite
position status: EQUAL
sequence position: 174

SequenceSite12014
type: SequenceSite
position status: EQUAL
sequence position: 174

UnificationXref18859
type: UnificationXref
id: 6244819
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244819

SequenceSite12013
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite12016
type: SequenceSite
position status: EQUAL
sequence position: 559

UnificationXref18857
type: UnificationXref
id: 6244817
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244817

SequenceSite12015
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18858
type: UnificationXref
id: 6244818
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244818

http://identifiers.org/pubmed/23599745
type: PublicationXref
id: 23599745
author: Hamid, Abdu Selim
author: Tesfamariam, Isaias Goitom
author: Zhang, Zhen Gui
author: Zhang, Yucheng
db: Pubmed
title: Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention
source: Oncol Lett 5:1087-1092
year: 2013

SequenceSite12006
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18867
type: UnificationXref
id: 6254225
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254225

SequenceSite12007
type: SequenceSite
position status: EQUAL
sequence position: 559

UnificationXref18866
type: UnificationXref
id: REACT_246911
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_246911.1

SequenceSite12008
type: SequenceSite
position status: EQUAL
sequence position: 174

UnificationXref18865
type: UnificationXref
id: 6244831
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244831

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

SequenceSite12009
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18864
type: UnificationXref
id: REACT_261170
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_261170.1

UnificationXref18863
type: UnificationXref
id: 6254228
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254228

UnificationXref18862
type: UnificationXref
id: REACT_230067
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230067.1

UnificationXref18861
type: UnificationXref
id: 6244822
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244822

UnificationXref18860
type: UnificationXref
id: 6244820
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244820

SequenceSite12001
type: SequenceSite
position status: EQUAL
sequence position: 1148

SequenceSite12000
type: SequenceSite
position status: EQUAL
sequence position: 1108

SequenceSite12005
type: SequenceSite
position status: EQUAL
sequence position: 174

UnificationXref18868
type: UnificationXref
id: REACT_231757
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231757.1

SequenceSite12004
type: SequenceSite
position status: EQUAL
sequence position: 1599

UnificationXref18869
type: UnificationXref
id: 6239071
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239071

SequenceSite12003
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12002
type: SequenceSite
position status: EQUAL
sequence position: 1192

UnificationXref18870
type: UnificationXref
id: 6239072
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239072

UnificationXref18876
type: UnificationXref
id: 6239078
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239078

UnificationXref18875
type: UnificationXref
id: 6239077
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239077

UnificationXref18878
type: UnificationXref
id: 6239080
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239080

UnificationXref18877
type: UnificationXref
id: 6239079
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239079

UnificationXref18872
type: UnificationXref
id: 6239074
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239074

UnificationXref18871
type: UnificationXref
id: 6239073
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239073

http://identifiers.org/pubmed/7596435
type: PublicationXref
id: 7596435
author: Rossant, J
author: Shalaby, F
author: Gertsenstein, M
author: Schuh, A C
author: Yamaguchi, T P
author: Breitman, M L
author: Wu, X F
db: Pubmed
title: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
source: Nature 376:62-6
year: 1995

UnificationXref18874
type: UnificationXref
id: 6239076
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239076

UnificationXref18873
type: UnificationXref
id: 6239075
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239075

UnificationXref18837
type: UnificationXref
id: 6244785
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244785

UnificationXref18838
type: UnificationXref
id: Q0WRY5
db: UniProt

UnificationXref18835
type: UnificationXref
id: 6244782
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244782

UniProt:F4K4E3
type: ProteinReference
xref: UnificationXref478
organism: http://identifiers.org/taxonomy/3702

UnificationXref18836
type: UnificationXref
id: F4JTH1
db: UniProt

UnificationXref18839
type: UnificationXref
id: 6244788
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244788

UnificationXref18841
type: UnificationXref
id: 6244791
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244791

http://identifiers.org/pubmed/12438414
type: PublicationXref
id: 12438414
author: Michael, WM
author: Van Hatten, RA
author: Holway, AH
author: Tutter, AV
author: Khederian, AM
author: Walter, JC
db: Pubmed
title: The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.
source: J Cell Biol 159:541-7
year: 2002

UnificationXref18840
type: UnificationXref
id: Q9FFD4
db: UniProt

UnificationXref18845
type: UnificationXref
id: 6244797
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244797

UnificationXref18844
type: UnificationXref
id: F4IQ85
db: UniProt

UnificationXref18843
type: UnificationXref
id: 6244794
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244794

UnificationXref18842
type: UnificationXref
id: Q93Y19
db: UniProt

UnificationXref18846
type: UnificationXref
id: Q9SX57
db: UniProt

UnificationXref18847
type: UnificationXref
id: 6244800
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244800

UnificationXref18848
type: UnificationXref
id: F4IRL6
db: UniProt

UnificationXref18849
type: UnificationXref
id: 6244803
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244803

http://identifiers.org/pubmed/9251237
type: PublicationXref
id: 9251237
author: Gallagher, JT
author: Stringer, SE
db: Pubmed
title: Heparan sulphate
source: Int J Biochem Cell Biol 29:709-14
year: 1997

UnificationXref18850
type: UnificationXref
id: Q1PDV6
db: UniProt

UnificationXref18852
type: UnificationXref
id: Q9SFX0
db: UniProt

UnificationXref18851
type: UnificationXref
id: 6244806
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244806

UnificationXref18854
type: UnificationXref
id: Q8LPR4
db: UniProt

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

UnificationXref18853
type: UnificationXref
id: 6244809
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244809

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

UnificationXref18856
type: UnificationXref
id: O49338
db: UniProt

UnificationXref18855
type: UnificationXref
id: 6244812
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6244812

SequenceSite12050
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12051
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12052
type: SequenceSite
position status: EQUAL
sequence position: 188

UniProt:F4JSG3
type: ProteinReference
xref: UnificationXref3238
organism: http://identifiers.org/taxonomy/3702

SequenceSite12053
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12054
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12055
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12056
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12057
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

SequenceSite12058
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12059
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9593755
type: PublicationXref
id: 9593755
author: Garber, Ellen A
author: Miatkowski, Konrad
author: Wang, Elizabeth A
author: Baker, Darren P
author: Bixler, Sarah A
author: Rayhorn, Paul
author: Williams, Kevin P
author: Ambrose, Christine M
author: Pepinsky, R Blake
author: Zeng, Chenhui
author: Wen, Dingyi
author: Taylor, Frederick R
author: Galdes, Alphonse
db: Pubmed
title: Identification of a palmitic acid-modified form of human Sonic hedgehog
source: J. Biol. Chem. 273:14037-45
year: 1998

SequenceSite12040
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12041
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12044
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12045
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12042
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12043
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12048
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12049
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12046
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12047
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12039
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12030
type: SequenceSite
position status: EQUAL
sequence position: 552

SequenceSite12035
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12036
type: SequenceSite
position status: EQUAL
sequence position: 188

SequenceSite12037
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12038
type: SequenceSite
position status: EQUAL
sequence position: 188

UnificationXref18879
type: UnificationXref
id: 6239081
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239081

SequenceSite12031
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12032
type: SequenceSite
position status: EQUAL
sequence position: 552

SequenceSite12033
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12034
type: SequenceSite
position status: EQUAL
sequence position: 382

UnificationXref18884
type: UnificationXref
id: 6239086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239086

UnificationXref18885
type: UnificationXref
id: 6239087
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239087

UnificationXref18882
type: UnificationXref
id: 6239084
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239084

UnificationXref18883
type: UnificationXref
id: 6239085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239085

SequenceSite12029
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18888
type: UnificationXref
id: 6239090
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239090

SequenceSite12028
type: SequenceSite
position status: EQUAL
sequence position: 552

UnificationXref18889
type: UnificationXref
id: 6239091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239091

UnificationXref18886
type: UnificationXref
id: 6239088
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239088

UnificationXref18887
type: UnificationXref
id: 6239089
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239089

UnificationXref18880
type: UnificationXref
id: 6239082
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239082

UnificationXref18881
type: UnificationXref
id: 6239083
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239083

SequenceSite12026
type: SequenceSite
position status: EQUAL
sequence position: 552

SequenceSite12027
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12024
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite12025
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12022
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite12023
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12020
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite12021
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18893
type: UnificationXref
id: 6239095
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239095

UnificationXref18894
type: UnificationXref
id: 6239096
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239096

UnificationXref18895
type: UnificationXref
id: 6239097
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239097

UnificationXref18896
type: UnificationXref
id: 6239098
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239098

UnificationXref18897
type: UnificationXref
id: 6239099
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239099

SequenceSite12019
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18898
type: UnificationXref
id: 6239100
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239100

SequenceSite12018
type: SequenceSite
position status: EQUAL
sequence position: 559

UnificationXref18899
type: UnificationXref
id: 6239101
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239101

SequenceSite12017
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18890
type: UnificationXref
id: 6239092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239092

UnificationXref18891
type: UnificationXref
id: 6239093
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239093

UnificationXref18892
type: UnificationXref
id: 6239094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239094

http://identifiers.org/pubmed/12807873
type: PublicationXref
id: 12807873
author: Kömüves, LG
author: Ng, CK
author: Topper, JN
author: Wasserman, SM
author: Yang, RB
author: Gerritsen, ME
db: Pubmed
title: A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling
source: J Biol Chem 278:33232-8
year: 2003

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

http://identifiers.org/pubmed/22090471
type: PublicationXref
id: 22090471
author: Jan, Lily Y
author: Huang, Fen
author: Wong, Xiuming
db: Pubmed
title: International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels
source: Pharmacol. Rev. 64:1-15
year: 2012

http://identifiers.org/pubmed/18481987
type: PublicationXref
id: 18481987
author: Sandler, H
author: Stoecklin, G
db: Pubmed
title: Control of mRNA decay by phosphorylation of tristetraprolin
source: Biochem Soc Trans 36:491-6
year: 2008

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

http://identifiers.org/pubmed/12807890
type: PublicationXref
id: 12807890
author: Walker, JE
author: Dionisi-Vici, C
author: Dolce, V
author: Palmieri, F
author: Fiermonte, G
author: David, L
author: Santorelli, FM
db: Pubmed
title: The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
source: J Biol Chem 278:32778-83
year: 2003

Signaling by FGFR1 fusion mutants
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction526
pathway component: BiochemicalReaction529
pathway component: BiochemicalReaction528
pathway component: BiochemicalReaction527
pathway component: BiochemicalReaction530
pathway component: BiochemicalReaction531
evidence: Evidence832
xref: UnificationXref10167
xref: UnificationXref10168
pathway order: PathwayStep806
pathway order: PathwayStep805
pathway order: PathwayStep808
pathway order: PathwayStep807
pathway order: PathwayStep804
pathway order: PathwayStep803
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction961
evidence: Evidence1461
xref: UnificationXref15383
xref: UnificationXref15382
pathway order: PathwayStep1434
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12061
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12060
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12063
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12062
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12065
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12064
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12067
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12066
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12069
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12068
type: SequenceSite
position status: EQUAL
sequence position: 202

http://identifiers.org/pubmed/9799232
type: PublicationXref
id: 9799232
author: Wagner, H
author: Mischak, H
author: Sparwasser, T
author: Lipford, GB
author: Schmid, R
author: Heeg, K
author: Miethke, T
author: Hacker, H
author: Liptay, S
db: Pubmed
title: CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
source: EMBO J 17:6230-40
year: 1998

http://identifiers.org/pubmed/9799231
type: PublicationXref
id: 9799231
author: Guillemot, JC
author: Chavrier, P
author: Montcourrier, P
author: Massol, P
db: Pubmed
title: Fc receptor-mediated phagocytosis requires CDC42 and Rac1
source: EMBO J 17:6219-29
year: 1998

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

SequenceSite12070
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12074
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12073
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12072
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12071
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12078
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12077
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12076
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12075
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12079
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12083
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12082
type: SequenceSite
position status: EQUAL
sequence position: 211

UniProt:P49201
type: ProteinReference
xref: UnificationXref1220
organism: http://identifiers.org/taxonomy/3702

SequenceSite12085
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P49200
type: ProteinReference
xref: UnificationXref1299
organism: http://identifiers.org/taxonomy/3702

SequenceSite12084
type: SequenceSite
position status: EQUAL
sequence position: 211

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

SequenceSite12081
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12080
type: SequenceSite
position status: EQUAL
sequence position: 211

UniProt:P49209
type: ProteinReference
xref: UnificationXref1021
organism: http://identifiers.org/taxonomy/3702

SequenceSite12087
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P49206
type: ProteinReference
xref: UnificationXref1163
organism: http://identifiers.org/taxonomy/3702

SequenceSite12086
type: SequenceSite
position status: EQUAL
sequence position: 211

UniProt:P49205
type: ProteinReference
xref: UnificationXref1237
organism: http://identifiers.org/taxonomy/3702

SequenceSite12089
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P49204
type: ProteinReference
xref: UnificationXref1330
organism: http://identifiers.org/taxonomy/3702

SequenceSite12088
type: SequenceSite
position status: EQUAL
sequence position: 211

http://identifiers.org/pubmed/12032886
type: PublicationXref
id: 12032886
author: Zhou, B
author: Wang, K
author: Gitschier, J
author: Zemansky, J
author: Kuo, YM
db: Pubmed
title: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
source: Am J Hum Genet 71:66-73
year: 2002

SequenceSite12096
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12095
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12094
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12093
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12092
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12091
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12090
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12099
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12098
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12097
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

UniProt:Q94K13
type: ProteinReference
xref: UnificationXref11221
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

UniProt:P49227
type: ProteinReference
xref: UnificationXref1026
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/16682955
type: PublicationXref
id: 16682955
author: Hays, S
author: Westbrook, L
author: Qu, Z
author: Kern, FG
author: Thottassery, JV
author: Rentz, SS
author: Manuvakhova, M
db: Pubmed
title: Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
source: Oncogene 25:6003-14
year: 2006

UniProt:Q94K08
type: ProteinReference
xref: UnificationXref11460
organism: http://identifiers.org/taxonomy/3702

UniProt:Q94K05
type: ProteinReference
xref: UnificationXref20103
organism: http://identifiers.org/taxonomy/3702

UniProt:P49211
type: ProteinReference
xref: UnificationXref951
organism: http://identifiers.org/taxonomy/3702

UniProt:Q94K30
type: ProteinReference
xref: UnificationXref14531
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/11427893
type: PublicationXref
id: 11427893
author: Ramaswamy, S
author: Eklund, H
author: Eriksson, S
author: Piskur, J
author: Munch-Petersen, B
author: Johansson, K
author: Knecht, W
author: Ljungcrantz, C
db: Pubmed
title: Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
source: Nat Struct Biol 8:616-620
year: 2001

UniProt:Q94JQ3
type: ProteinReference
xref: UnificationXref11798
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

ubiquitinylated lysine
type: SequenceModificationVocabulary
xref: UnificationXref601

http://identifiers.org/pubmed/15591024
type: PublicationXref
id: 15591024
author: Takano, K
author: Yoshida, M
author: Asai, M
author: Oiso, Y
author: Itoi, K
author: Yamamori, E
author: Iwasaki, Y
db: Pubmed
title: Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
source: J Mol Endocrinol 33:639-49
year: 2004

http://identifiers.org/pubmed/8163536
type: PublicationXref
id: 8163536
author: Sidorenko, SP
author: Chandran, KA
author: Clark, EA
author: Disteche, CM
author: Edelhoff, S
author: Law, CL
author: Weiss, A
author: Chan, AC
author: Draves, KE
db: Pubmed
title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex
source: J Biol Chem 269:12310-9
year: 1994

UniProt:Q94K57
type: ProteinReference
xref: UnificationXref16145
organism: http://identifiers.org/taxonomy/3702

UniProt:Q94K56
type: ProteinReference
xref: UnificationXref21098
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/15270074
type: PublicationXref
id: 15270074
author: Kingston, Robert E
author: Chen, Will C
author: Trinklein, Nathan D
author: Myers, Richard M
db: Pubmed
title: Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
source: Cell Stress Chaperones 9:21-8
year: 2004

http://identifiers.org/pubmed/11735028
type: PublicationXref
id: 11735028
author: Minoshima, S
author: Hiratsuka, M
author: Inui, K
author: Kure, S
author: Narisawa, K
author: Yang, X
author: Aoki, Y
author: Ohki, M
author: Kudoh, J
author: Shintani, A
author: Christensen, E
author: Kubota, M
author: Li, X
author: Taheri, S
author: Suzuki, Y
author: Kawasaki, K
author: Sakamoto, O
author: Shimizu, N
author: Asakawa, S
author: Shibuya, K
author: Ohira, M
author: Matsubara, Y
db: Pubmed
title: Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiency
source: Hum. Genet. 109:526-34
year: 2001

SequenceSite1900
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1902
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1901
type: SequenceSite
position status: EQUAL
sequence position: 2442

SequenceSite1905
type: SequenceSite
position status: EQUAL
sequence position: 2442

SequenceSite1906
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1903
type: SequenceSite
position status: EQUAL
sequence position: 2442

SequenceSite1904
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q94K41
type: ProteinReference
xref: UnificationXref14566
organism: http://identifiers.org/taxonomy/3702

SequenceSite1909
type: SequenceSite
position status: EQUAL
sequence position: 2442

SequenceSite1907
type: SequenceSite
position status: EQUAL
sequence position: 2442

SequenceSite1908
type: SequenceSite
position status: EQUAL
sequence position: 1

Signaling by Vascular Epithelial Growth Factors (VEGF)
type: Pathway
data source: Provenance1
pathway component: REACT 261506.1
evidence: Evidence1974
xref: RelationshipXref1658
xref: UnificationXref19596
xref: UnificationXref19597
pathway order: PathwayStep1940
display name: Signaling by VEGF
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite1913
type: SequenceSite
position status: EQUAL
sequence position: 547

SequenceSite1912
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1911
type: SequenceSite
position status: EQUAL
sequence position: 1332

SequenceSite1910
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q94K73
type: ProteinReference
xref: UnificationXref7556
organism: http://identifiers.org/taxonomy/3702

UniProt:F4K0J5
type: ProteinReference
xref: UnificationXref6961
organism: http://identifiers.org/taxonomy/3702

UniProt:Q94JU6
type: ProteinReference
xref: UnificationXref2221
organism: http://identifiers.org/taxonomy/3702

UnificationXref18913
type: UnificationXref
id: REACT_206984
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206984.2

UnificationXref18912
type: UnificationXref
id: 6239588
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239588

UnificationXref18915
type: UnificationXref
id: REACT_208246
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_208246.2

UnificationXref18914
type: UnificationXref
id: 6254086
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254086

UnificationXref18917
type: UnificationXref
id: REACT_206508
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_206508.2

UnificationXref18916
type: UnificationXref
id: 6254083
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254083

UnificationXref18919
type: UnificationXref
id: REACT_205287
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_205287.2

UnificationXref18918
type: UnificationXref
id: 6254085
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254085

SequenceSite1954
type: SequenceSite
position status: EQUAL
sequence position: 410

SequenceSite1955
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1956
type: SequenceSite
position status: EQUAL
sequence position: 410

SequenceSite1957
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1950
type: SequenceSite
position status: EQUAL
sequence position: 499

SequenceSite1951
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1952
type: SequenceSite
position status: EQUAL
sequence position: 718

SequenceSite1953
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1948
type: SequenceSite
position status: EQUAL
sequence position: 297

SequenceSite1947
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1949
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17555535
type: PublicationXref
id: 17555535
author: Sherwood, MW
author: Burgoyne, RD
author: Dolman, NJ
author: Haynes, LP
db: Pubmed
title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta
source: Traffic 8:1080-92
year: 2007

UnificationXref18920
type: UnificationXref
id: 6253871
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253871

UnificationXref18921
type: UnificationXref
id: REACT_224601
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_224601.2

UnificationXref18922
type: UnificationXref
id: 6253879
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253879

UnificationXref18926
type: UnificationXref
id: Q8GWW6
db: UniProt

UnificationXref18925
type: UnificationXref
id: 6249347
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249347

UnificationXref18924
type: UnificationXref
id: O65340
db: UniProt

UnificationXref18923
type: UnificationXref
id: REACT_221601
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_221601.2

UnificationXref18929
type: UnificationXref
id: O23507
db: UniProt

UnificationXref18928
type: UnificationXref
id: 6249349
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249349

UnificationXref18927
type: UnificationXref
id: 6249348
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249348

SequenceSite1945
type: SequenceSite
position status: EQUAL
sequence position: 398

SequenceSite1946
type: SequenceSite
position status: EQUAL
sequence position: 14

SequenceSite1943
type: SequenceSite
position status: EQUAL
sequence position: 433

SequenceSite1944
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1941
type: SequenceSite
position status: EQUAL
sequence position: 297

UniProt:Q94IV0
type: ProteinReference
xref: UnificationXref3761
organism: http://identifiers.org/taxonomy/3702

SequenceSite1942
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1940
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1939
type: SequenceSite
position status: EQUAL
sequence position: 731

SequenceSite1938
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1937
type: SequenceSite
position status: EQUAL
sequence position: 3056

SequenceSite1936
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18932
type: UnificationXref
id: 6249351
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249351

UnificationXref18933
type: UnificationXref
id: Q84W77
db: UniProt

UnificationXref18930
type: UnificationXref
id: 6249350
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249350

UnificationXref18931
type: UnificationXref
id: Q8LET7
db: UniProt

UnificationXref18939
type: UnificationXref
id: 6249333
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249333

UnificationXref18938
type: UnificationXref
id: 6249332
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249332

UnificationXref18935
type: UnificationXref
id: 6249353
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249353

UnificationXref18934
type: UnificationXref
id: 6249352
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249352

UnificationXref18937
type: UnificationXref
id: 6249330
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249330

UnificationXref18936
type: UnificationXref
id: 6249354
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249354

SequenceSite1930
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1931
type: SequenceSite
position status: EQUAL
sequence position: 731

SequenceSite1932
type: SequenceSite
position status: EQUAL
sequence position: 387

SequenceSite1933
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1934
type: SequenceSite
position status: EQUAL
sequence position: 731

SequenceSite1935
type: SequenceSite
position status: EQUAL
sequence position: 1981

SequenceSite1926
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1925
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite1928
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1927
type: SequenceSite
position status: EQUAL
sequence position: 361

SequenceSite1929
type: SequenceSite
position status: EQUAL
sequence position: 375

UnificationXref18941
type: UnificationXref
id: 6249398
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249398

UnificationXref18942
type: UnificationXref
id: 6249399
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249399

UnificationXref18943
type: UnificationXref
id: 6249400
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249400

UnificationXref18944
type: UnificationXref
id: 6249401
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249401

UnificationXref18940
type: UnificationXref
id: 6249397
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249397

UnificationXref18949
type: UnificationXref
id: 6254323
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254323

UnificationXref18948
type: UnificationXref
id: REACT_187658
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187658.3

UnificationXref18947
type: UnificationXref
id: 6254322
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254322

UnificationXref18946
type: UnificationXref
id: REACT_192231
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_192231.3

UnificationXref18945
type: UnificationXref
id: 6249402
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6249402

Formation of the Early Elongation Complex
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction314
pathway component: BiochemicalReaction315
evidence: Evidence500
xref: RelationshipXref228
xref: UnificationXref6240
xref: UnificationXref6239
pathway order: PathwayStep478
pathway order: PathwayStep479
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite1920
type: SequenceSite
position status: EQUAL
sequence position: 4

SequenceSite1923
type: SequenceSite
position status: EQUAL
sequence position: 4

SequenceSite1924
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1921
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1922
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite1917
type: SequenceSite
position status: EQUAL
sequence position: 424

SequenceSite1916
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1915
type: SequenceSite
position status: EQUAL
sequence position: 826

SequenceSite1914
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1919
type: SequenceSite
position status: EQUAL
sequence position: 266

SequenceSite1918
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18954
type: UnificationXref
id: REACT_244173
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244173.1

UnificationXref18955
type: UnificationXref
id: 6239536
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239536

UnificationXref18952
type: UnificationXref
id: REACT_187657
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187657.3

UnificationXref18953
type: UnificationXref
id: 6253795
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253795

UnificationXref18950
type: UnificationXref
id: REACT_187650
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187650.3

UnificationXref18951
type: UnificationXref
id: 6254324
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254324

SequenceSite1999
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1998
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1995
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1994
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1997
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/1703535
type: PublicationXref
id: 1703535
author: Purdue, PE
author: Danpure, CJ
author: Takada, Y
db: Pubmed
title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
source: J Cell Biol 111:2341-51
year: 1990

SequenceSite1996
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1991
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1990
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1993
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1992
type: SequenceSite
position status: EQUAL
sequence position: 700

http://identifiers.org/pubmed/11863375
type: PublicationXref
id: 11863375
author: Yang, RZ
author: Shuldiner, AR
author: Gong, DW
author: Blaileanu, G
author: Hansen, BC
db: Pubmed
title: cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
source: Genomics 79:445-50
year: 2002

SequenceSite1989
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1988
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1987
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1986
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1985
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1984
type: SequenceSite
position status: EQUAL
sequence position: 700

SequenceSite1983
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1982
type: SequenceSite
position status: EQUAL
sequence position: 346

SequenceSite1981
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1980
type: SequenceSite
position status: EQUAL
sequence position: 346

abacavir [ChEBI:421707]
type: SmallMoleculeReference
name: abacavir
name: {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
xref: UnificationXref18456

SequenceSite1973
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1972
type: SequenceSite
position status: EQUAL
sequence position: 482

SequenceSite1975
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1974
type: SequenceSite
position status: EQUAL
sequence position: 482

SequenceSite1977
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1976
type: SequenceSite
position status: EQUAL
sequence position: 1139

SequenceSite1979
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1978
type: SequenceSite
position status: EQUAL
sequence position: 346

http://identifiers.org/pubmed/11435118
type: PublicationXref
id: 11435118
author: Timm, DE
author: Harris, RA
author: Dorocke, JA
author: Baker, LJ
db: Pubmed
title: The crystal structure of yeast thiamin pyrophosphokinase
source: Structure 9:539-46
year: 2001

SequenceSite1971
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1970
type: SequenceSite
position status: EQUAL
sequence position: 482

UnificationXref18900
type: UnificationXref
id: 6239102
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239102

SequenceSite1969
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1964
type: SequenceSite
position status: EQUAL
sequence position: 413

SequenceSite1963
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1962
type: SequenceSite
position status: EQUAL
sequence position: 413

SequenceSite1961
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10783391
type: PublicationXref
id: 10783391
author: Gabel, CA
author: Schulte, GK
author: Hoth, LR
author: Chelvanayagam, G
author: Chrunyk, BA
author: Geoghegan, KF
author: Coggan, M
author: Easteal, S
author: Kamath, AV
author: Board, PG
author: Jermiin, LS
author: Pandit, J
author: Rosner, MH
author: Perregaux, DE
author: Danley, DE
author: Griffor, MC
db: Pubmed
title: Identification, characterization, and crystal structure of the Omega class glutathione transferases
source: J Biol Chem 275:24798-806
year: 2000

SequenceSite1968
type: SequenceSite
position status: EQUAL
sequence position: 1068

SequenceSite1967
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

UnificationXref18909
type: UnificationXref
id: REACT_230985
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_230985.1

SequenceSite1966
type: SequenceSite
position status: EQUAL
sequence position: 413

SequenceSite1965
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref18907
type: UnificationXref
id: 6239109
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239109

UnificationXref18908
type: UnificationXref
id: 6239111
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239111

UnificationXref18905
type: UnificationXref
id: 6239107
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239107

UnificationXref18906
type: UnificationXref
id: 6239108
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239108

UnificationXref18903
type: UnificationXref
id: 6239105
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239105

SequenceSite1960
type: SequenceSite
position status: EQUAL
sequence position: 446

UnificationXref18904
type: UnificationXref
id: 6239106
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239106

UnificationXref18901
type: UnificationXref
id: 6239103
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239103

UnificationXref18902
type: UnificationXref
id: 6239104
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239104

UnificationXref18911
type: UnificationXref
id: 6239586
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239586

UnificationXref18910
type: UnificationXref
id: Q9M8K7
db: UniProt

SequenceSite1958
type: SequenceSite
position status: EQUAL
sequence position: 446

SequenceSite1959
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12149
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12156
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12157
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12158
type: SequenceSite
position status: EQUAL
sequence position: 618

SequenceSite12159
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12152
type: SequenceSite
position status: EQUAL
sequence position: 189

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

SequenceSite12153
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12154
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12155
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12150
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12151
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12139
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12138
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12147
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12148
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12145
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12146
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12143
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12144
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12141
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12142
type: SequenceSite
position status: EQUAL
sequence position: 189

SequenceSite12140
type: SequenceSite
position status: EQUAL
sequence position: 189

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

SequenceSite12174
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite12175
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12176
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite12177
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12178
type: SequenceSite
position status: EQUAL
sequence position: 993

Homologues of TCEA1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21988
cellular location: GO_0005654
comment: Reactome DB_ID: 6234073
comment: Converted from EntitySet in Reactome

SequenceSite12179
type: SequenceSite
position status: EQUAL
sequence position: 321

Homologues of ERCC8
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22001
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6234094

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q93ZG3
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: Q93ZG3
name: CSA protein
xref: UnificationXref21990
feature: FragmentFeature6547
cellular location: GO_0005654
comment: Reactome DB_ID: 6234081
display name: ERCC8

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZVH8
data source: Provenance1
name: Transcription elongation factor TFIIS.o
name: TFIIS protein
name: Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)
name: Transcription elongation factor A protein 1
name: Q9ZVH8
name: Transcription elongation factor S-II protein 1
xref: UnificationXref21985
feature: FragmentFeature6545
cellular location: GO_0005654
comment: Reactome DB_ID: 6234070
display name: TCEA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VXZ6
data source: Provenance1
name: Transcription elongation factor TFIIS.o
name: TFIIS protein
name: Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)
name: Transcription elongation factor A protein 1
name: Q8VXZ6
name: Transcription elongation factor S-II protein 1
xref: UnificationXref21987
feature: FragmentFeature6546
cellular location: GO_0005654
comment: Reactome DB_ID: 6234072
display name: TCEA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4HQX6
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: CSA protein
name: F4HQX6
xref: UnificationXref21996
feature: FragmentFeature6550
cellular location: GO_0005654
comment: Reactome DB_ID: 6234089
display name: ERCC8

SequenceSite12170
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9C6N4
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: Q9C6N4
name: CSA protein
xref: UnificationXref21998
feature: FragmentFeature6551
cellular location: GO_0005654
comment: Reactome DB_ID: 6234091
display name: ERCC8

SequenceSite12171
type: SequenceSite
position status: EQUAL
sequence position: 321

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q680F0
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: Q680F0
name: CSA protein
xref: UnificationXref21992
feature: FragmentFeature6548
cellular location: GO_0005654
comment: Reactome DB_ID: 6234083
display name: ERCC8

SequenceSite12172
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FXH4
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: Q9FXH4
name: CSA protein
xref: UnificationXref21994
feature: FragmentFeature6549
cellular location: GO_0005654
comment: Reactome DB_ID: 6234087
display name: ERCC8

SequenceSite12173
type: SequenceSite
position status: EQUAL
sequence position: 321

http://identifiers.org/pubmed/1968462
type: PublicationXref
id: 1968462
author: Edwards, PA
author: Kutsunai, SY
author: Wilkin, DJ
db: Pubmed
title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester
source: J Biol Chem 265:4607-14
year: 1990

3-Ureidoisobutyrate
type: SmallMoleculeReference
name: 3-ureidoisobutyric acid
name: ChEBI:1670 3-ureidoisobutyric acid
xref: UnificationXref16187

SequenceSite12165
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12166
type: SequenceSite
position status: EQUAL
sequence position: 618

SequenceSite12163
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12164
type: SequenceSite
position status: EQUAL
sequence position: 618

SequenceSite12169
type: SequenceSite
position status: EQUAL
sequence position: 321

KSRP destabilizes mRNA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction22
pathway component: BiochemicalReaction23
evidence: Evidence36
xref: UnificationXref823
xref: UnificationXref822
pathway order: PathwayStep33
pathway order: PathwayStep32
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12167
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12168
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite12161
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12162
type: SequenceSite
position status: EQUAL
sequence position: 618

SequenceSite12160
type: SequenceSite
position status: EQUAL
sequence position: 618

SequenceSite12109
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18962
type: UnificationXref
id: 6239543
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239543

UnificationXref18961
type: UnificationXref
id: 6239542
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239542

UnificationXref18960
type: UnificationXref
id: 6239541
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239541

SequenceSite12105
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18966
type: UnificationXref
id: 6239547
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239547

SequenceSite12106
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18965
type: UnificationXref
id: 6239546
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239546

SequenceSite12107
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18964
type: UnificationXref
id: 6239545
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239545

SequenceSite12108
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18963
type: UnificationXref
id: 6239544
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239544

IRS-related events
type: Pathway
data source: Provenance1
pathway component: REACT 231305.1
evidence: Evidence1952
xref: UnificationXref19537
xref: UnificationXref19538
pathway order: PathwayStep1918
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O65607
data source: Provenance1
name: MSH3_HUMAN
name: O65607
name: DNA mismatch repair protein Msh3
xref: UnificationXref22105
feature: FragmentFeature6565
cellular location: GO_0005654
comment: Reactome DB_ID: 6253494
display name: MSH3

Exonuclease 1
type: Protein
entity reference: Q9LMS6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9LMS6
name: EXO1_HUMAN
xref: UnificationXref22091
feature: FragmentFeature6564
cellular location: GO_0005654
comment: Reactome DB_ID: 6253518
display name: EXO1

Exonuclease 1
type: Protein
entity reference: F4IAM4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EXO1_HUMAN
name: F4IAM4
xref: UnificationXref22089
feature: FragmentFeature6563
cellular location: GO_0005654
comment: Reactome DB_ID: 6253516
display name: EXO1

SequenceSite12113
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18958
type: UnificationXref
id: 6239539
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239539

Exonuclease 1
type: Protein
entity reference: Q94A33
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EXO1_HUMAN
name: Q94A33
xref: UnificationXref22087
feature: FragmentFeature6562
cellular location: GO_0005654
comment: Reactome DB_ID: 6253514
display name: EXO1

SequenceSite12112
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18959
type: UnificationXref
id: 6239540
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239540

Homologues of EXO1
type: Protein
data source: Provenance1
member physical entity: Exonuclease 1
xref: UnificationXref22092
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6253519

SequenceSite12115
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18956
type: UnificationXref
id: 6239537
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239537

SequenceSite12114
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18957
type: UnificationXref
id: 6239538
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239538

SequenceSite12111
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10092647
type: PublicationXref
id: 10092647
author: Wang, X
author: Nowatzke, W
author: Ramanadham, S
author: Ma, Z
author: Turk, J
db: Pubmed
title: Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1
source: J Biol Chem 274:9607-16
year: 1999

SequenceSite12110
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18971
type: UnificationXref
id: REACT_260006
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_260006.1

http://identifiers.org/pubmed/17170135
type: PublicationXref
id: 17170135
author: Li, JL
author: Gimeno, RE
author: Li, D
author: Tobin, JF
author: Cao, J
db: Pubmed
title: Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
source: Proc Natl Acad Sci U S A 103:19695-700
year: 2006

UnificationXref18970
type: UnificationXref
id: 6254094
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254094

UnificationXref18973
type: UnificationXref
id: REACT_253057
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_253057.1

UnificationXref18972
type: UnificationXref
id: 6239535
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239535

UnificationXref18975
type: UnificationXref
id: 6239518
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239518

UnificationXref18974
type: UnificationXref
id: 6239514
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239514

UnificationXref18977
type: UnificationXref
id: REACT_231995
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231995.1

UnificationXref18976
type: UnificationXref
id: 6239519
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239519

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4HUT3
data source: Provenance1
name: DNA excision repair protein ERCC-8
name: Cockayne syndrome WD-repeat protein CSA
name: F4HUT3
name: CSA protein
xref: UnificationXref22000
feature: FragmentFeature6552
cellular location: GO_0005654
comment: Reactome DB_ID: 6234093
display name: ERCC8

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O04716
data source: Provenance1
name: O04716
name: DNA mismatch repair protein Msh6
name: MSH6_HUMAN
xref: UnificationXref22064
feature: FragmentFeature6559
cellular location: GO_0005654
comment: Reactome DB_ID: 6253486
display name: MSH6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O24617
data source: Provenance1
name: DNA mismatch repair protein Msh2
name: O24617
name: MSH2_HUMAN
xref: UnificationXref22062
feature: FragmentFeature6558
cellular location: GO_0005654
comment: Reactome DB_ID: 6253482
display name: MSH2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZRV4
data source: Provenance1
name: MLH1_HUMAN
name: Q9ZRV4
name: DNA mismatch repair protein Mlh1
xref: UnificationXref22076
feature: FragmentFeature6561
cellular location: GO_0005654
comment: Reactome DB_ID: 6246568
display name: MLH1

Q941I6
type: Protein
entity reference: Q941I6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PMS2_HUMAN
name: Mismatch repair endonuclease PMS2 ecNumber3.1.-.-/ecNumber
xref: UnificationXref22074
feature: FragmentFeature6560
cellular location: GO_0005654
comment: Reactome DB_ID: 6253477
display name: PMS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B3H5R7
data source: Provenance1
name: FANCI_HUMAN
name: Fanconi anemia group I protein
name: B3H5R7
xref: UnificationXref22040
feature: FragmentFeature6555
cellular location: GO_0005654
comment: Reactome DB_ID: 6242605
display name: FANCI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4K4R1
data source: Provenance1
name: FANCI_HUMAN
name: F4K4R1
name: Fanconi anemia group I protein
xref: UnificationXref22038
feature: FragmentFeature6554
cellular location: GO_0005654
comment: Reactome DB_ID: 6242603
display name: FANCI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4JIJ1
data source: Provenance1
name: FACD2_HUMAN
name: F4JIJ1
name: Fanconi anemia group D2 protein
xref: UnificationXref22046
feature: FragmentFeature6557
cellular location: GO_0005654
comment: Reactome DB_ID: 6242598
display name: FANCD2

http://identifiers.org/pubmed/10371034
type: PublicationXref
id: 10371034
author: Rüegsegger, U
author: Wahle, E
db: Pubmed
title: 3'-End processing of pre-mRNA in eukaryotes.
source: FEMS Microbiol Rev 23:277-95
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FH23
data source: Provenance1
name: FANCI_HUMAN
name: Q9FH23
name: Fanconi anemia group I protein
xref: UnificationXref22042
feature: FragmentFeature6556
cellular location: GO_0005654
comment: Reactome DB_ID: 6242607
display name: FANCI

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

SequenceSite12104
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18967
type: UnificationXref
id: REACT_231798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_231798.1

SequenceSite12103
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18968
type: UnificationXref
id: 6239549
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6239549

Homologues of FANCI
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref22043
cellular location: GO_0005654
comment: Reactome DB_ID: 6242608
comment: Converted from EntitySet in Reactome

SequenceSite12102
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18969
type: UnificationXref
id: REACT_235547
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_235547.1

Q9LKU3
type: Protein
entity reference: Q9LKU3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HCNP protein
name: PP3898
name: XPA-binding protein 2
xref: UnificationXref22003
feature: FragmentFeature6553
cellular location: GO_0005654
comment: Reactome DB_ID: 6234077
display name: XAB2

SequenceSite12101
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12100
type: SequenceSite
position status: EQUAL
sequence position: 236

SequenceSite12127
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18988
type: UnificationXref
id: 6242063
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242063

SequenceSite12128
type: SequenceSite
position status: EQUAL
sequence position: 258

UnificationXref18987
type: UnificationXref
id: 6242062
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242062

SequenceSite12129
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18986
type: UnificationXref
id: 6242061
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242061

UnificationXref18985
type: UnificationXref
id: 6242059
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242059

UnificationXref18984
type: UnificationXref
id: 6241357
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6241357

UnificationXref18983
type: UnificationXref
id: REACT_187589
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187589.3

UnificationXref18982
type: UnificationXref
id: 6254387
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254387

UnificationXref18981
type: UnificationXref
id: REACT_254770
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_254770.1

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

UnificationXref18980
type: UnificationXref
id: 6254092
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254092

SequenceSite12131
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12130
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12133
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12132
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12135
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12134
type: SequenceSite
position status: EQUAL
sequence position: 258

http://identifiers.org/pubmed/21540551
type: PublicationXref
id: 21540551
author: Matejas, V
author: Kispert, A
author: Casarin, A
author: Faul, C
author: Pertegato, V
author: Akman, S
author: Kusakabe, T
author: Wang, S
author: Santos-Ocaña, C
author: Krick, S
author: Doimo, M
author: Hildebrandt, F
author: Chernin, G
author: Vega-Warner, V
author: McLaughlin, HM
author: Nürnberg, G
author: Navas, P
author: Chaki, M
author: Schoeb, DS
author: Becker, C
author: Saisawat, P
author: Heeringa, SF
author: Varpizen, S
author: Prokisch, H
author: Wiggins, RC
author: Nürnberg, P
author: Beissert, A
author: Zhou, W
author: Bakkaloglu, A
author: Ji, Z
author: Xie, LX
author: Hinkes, B
author: Bakkaloglu, SA
author: Salviati, L
author: Reiser, J
author: Vlangos, CN
author: Mir, S
author: Airik, R
author: Topaloglu, R
author: Sloan, AJ
author: Rötig, A
author: Trevisson, E
author: Gbadegesin, R
author: Raphael, Y
author: Zenker, M
author: Clarke, CF
author: Ozaltin, F
author: Soliman, NA
author: Müller, D
author: Berdeli, A
author: Ashraf, S
author: Killen, PD
author: Mundel, P
author: Hurd, TW
author: Giorgi, G
author: Ovunc, B
db: Pubmed
title: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
source: J Clin Invest 121:2013-24
year: 2011

SequenceSite12137
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18978
type: UnificationXref
id: 6254091
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254091

SequenceSite12136
type: SequenceSite
position status: EQUAL
sequence position: 258

UnificationXref18979
type: UnificationXref
id: REACT_241708
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_241708.1

SequenceSite12118
type: SequenceSite
position status: EQUAL
sequence position: 258

UnificationXref18997
type: UnificationXref
id: REACT_187584
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187584.3

SequenceSite12119
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18996
type: UnificationXref
id: 6254156
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254156

SequenceSite12116
type: SequenceSite
position status: EQUAL
sequence position: 236

UnificationXref18999
type: UnificationXref
id: REACT_245460
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_245460.1

SequenceSite12117
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref18998
type: UnificationXref
id: 6253766
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6253766

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

UnificationXref18993
type: UnificationXref
id: REACT_244798
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_244798.1

UnificationXref18992
type: UnificationXref
id: 6254154
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254154

UnificationXref18995
type: UnificationXref
id: REACT_187585
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_187585.3

UnificationXref18994
type: UnificationXref
id: 6254155
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6254155

UnificationXref18991
type: UnificationXref
id: REACT_259892
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_259892.1

UnificationXref18990
type: UnificationXref
id: 6242065
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242065

http://identifiers.org/pubmed/3391615
type: PublicationXref
id: 3391615
author: Robertson, D A
author: Baker, E G
author: Morris, C P
author: Hopwood, J J
author: Callen, D F
db: Pubmed
title: Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
source: Hum. Genet. 79:175-8
year: 1988

SequenceSite12122
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12121
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12120
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12126
type: SequenceSite
position status: EQUAL
sequence position: 258

UnificationXref18989
type: UnificationXref
id: 6242064
db: Reactome Database ID Release 49
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6242064

SequenceSite12125
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12124
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite12123
type: SequenceSite
position status: EQUAL
sequence position: 1

O64795
type: Protein
entity reference: O64795
data source: Provenance1
xref: UnificationXref21789
cellular location: GO_0005654
comment: Reactome DB_ID: 6234280

Q9CAG6
type: Protein
entity reference: Q9CAG6
data source: Provenance1
xref: UnificationXref21785
cellular location: GO_0005654
comment: Reactome DB_ID: 6234276

F4HTM5
type: Protein
entity reference: F4HTM5
data source: Provenance1
xref: UnificationXref21787
cellular location: GO_0005654
comment: Reactome DB_ID: 6234278

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8H2D5
data source: Provenance1
name: Q8H2D5
name: DNA polymerase eta
name: Pol eta protein
xref: UnificationXref21771
feature: FragmentFeature6510
cellular location: GO_0005654
comment: Reactome DB_ID: 6234265
display name: POLH

Homologues of hREV3(1-?)
type: Protein
data source: Provenance1
member physical entity: O64795
member physical entity: Q9CAG6
member physical entity: F4HTM5
member physical entity: Q766Z3
xref: UnificationXref21792
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6234283

P45951
type: Protein
entity reference: P45951
data source: Provenance1
xref: UnificationXref21688
cellular location: GO_0005654
comment: Reactome DB_ID: 6234297

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3EWL3
data source: Provenance1
name: DNA repair protein REV1 ecNumber2.7.7.-/ecNumber
name: REV1_HUMAN
name: A3EWL3
xref: UnificationXref21753
feature: FragmentFeature6509
cellular location: GO_0005654
comment: Reactome DB_ID: 6234254
display name: REV1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VZT5
data source: Provenance1
name: Q8VZT5
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21625
feature: FragmentFeature6507
cellular location: GO_0005654
comment: Reactome DB_ID: 6234188
display name: NTHL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q94EJ4
data source: Provenance1
name: Q94EJ4
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21627
feature: FragmentFeature6508
cellular location: GO_0005654
comment: Reactome DB_ID: 6234190
display name: NTHL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FT83
data source: Provenance1
name: Q9FT83
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21623
feature: FragmentFeature6506
cellular location: GO_0005654
comment: Reactome DB_ID: 6234186
display name: NTHL1

phospho-p-MDC1
type: Protein
entity reference: Q9LVF7
data source: Provenance1
xref: UnificationXref21825
feature: ModificationFeature614
feature: FragmentFeature6516
cellular location: GO_0005654
comment: Reactome DB_ID: 6233192

phospho-p-MDC1
type: Protein
entity reference: F4JI52
data source: Provenance1
xref: UnificationXref21826
feature: ModificationFeature615
feature: FragmentFeature6517
cellular location: GO_0005654
comment: Reactome DB_ID: 6233194

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LVF7
data source: Provenance1
name: Q9LVF7
name: MDC1/NFBD1
xref: UnificationXref21820
feature: FragmentFeature6513
cellular location: GO_0005654
comment: Reactome DB_ID: 6233185
display name: MDC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4JI52
data source: Provenance1
name: F4JI52
name: MDC1/NFBD1
xref: UnificationXref21822
feature: FragmentFeature6514
cellular location: GO_0005654
comment: Reactome DB_ID: 6233187
display name: MDC1

Homologues of p-MDC1
type: Protein
data source: Provenance1
member physical entity: phospho-p-MDC1
xref: UnificationXref21827
cellular location: GO_0005654
comment: Reactome DB_ID: 6233195
comment: Converted from EntitySet in Reactome

phospho-p-MDC1
type: Protein
entity reference: Q9ZR18
data source: Provenance1
xref: UnificationXref21824
feature: FragmentFeature6515
feature: ModificationFeature613
cellular location: GO_0005654
comment: Reactome DB_ID: 6233190

Q766Z3
type: Protein
entity reference: Q766Z3
data source: Provenance1
xref: UnificationXref21791
cellular location: GO_0005654
comment: Reactome DB_ID: 6234282

Mitotic spindle assembly checkpoint protein MAD2B
type: Protein
entity reference: Q94FL5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitotic spindle assembly checkpoint protein MAD2B (MAD2-like 2) (hREV7)
name: hREV7
name: MAD2L2
name: Q94FL5
name: MAD2-like 2
xref: UnificationXref21794
feature: FragmentFeature6511
cellular location: GO_0005654
comment: Reactome DB_ID: 6234287
display name: HREV7

Homologues of MDC1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21823
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6233188

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9ZR18
data source: Provenance1
name: Q9ZR18
name: MDC1/NFBD1
xref: UnificationXref21818
feature: FragmentFeature6512
cellular location: GO_0005654
comment: Reactome DB_ID: 6233181
display name: MDC1

Q39069
type: Protein
entity reference: Q39069
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21580
feature: FragmentFeature6495
cellular location: GO_0005654
comment: Reactome DB_ID: 6234149
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q39068
data source: Provenance1
name: Q39068
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21581
feature: FragmentFeature6496
cellular location: GO_0005654
comment: Reactome DB_ID: 6234150
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q39072
data source: Provenance1
name: UNG2
name: Uracil-DNA glycosylase 2
name: Q39072
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21578
feature: FragmentFeature6493
cellular location: GO_0005654
comment: Reactome DB_ID: 6234147
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SFW6
data source: Provenance1
name: Q9SFW6
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21579
feature: FragmentFeature6494
cellular location: GO_0005654
comment: Reactome DB_ID: 6234148
display name: CCNO

Homologues of MBD4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21603
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6234168

Q9SA32
type: Protein
entity reference: Q9SA32
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21573
feature: FragmentFeature6488
cellular location: GO_0005654
comment: Reactome DB_ID: 6234142
display name: CCNO

UniProt:Q94KI8
type: ProteinReference
xref: UnificationXref9776
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q39070
data source: Provenance1
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Q39070
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21576
feature: FragmentFeature6491
cellular location: GO_0005654
comment: Reactome DB_ID: 6234145
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LDM4
data source: Provenance1
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Q9LDM4
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21577
feature: FragmentFeature6492
cellular location: GO_0005654
comment: Reactome DB_ID: 6234146
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P30183
data source: Provenance1
name: UNG2
name: Uracil-DNA glycosylase 2
name: P30183
name: UDG 2
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21574
feature: FragmentFeature6489
cellular location: GO_0005654
comment: Reactome DB_ID: 6234143
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LM91
data source: Provenance1
name: UNG2
name: Uracil-DNA glycosylase 2
name: UDG 2
name: Q9LM91
name: Uracil-DNA glycosylase 2 (EC 3.2.2.-)
xref: UnificationXref21575
feature: FragmentFeature6490
cellular location: GO_0005654
comment: Reactome DB_ID: 6234144
display name: CCNO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SIC4
data source: Provenance1
name: Q9SIC4
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21615
feature: FragmentFeature6502
cellular location: GO_0005654
comment: Reactome DB_ID: 6234176
display name: NTHL1

Q8LF57
type: Protein
entity reference: Q8LF57
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21617
feature: FragmentFeature6503
cellular location: GO_0005654
comment: Reactome DB_ID: 6234178
display name: NTHL1

B9DFZ0
type: Protein
entity reference: B9DFZ0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21619
feature: FragmentFeature6504
cellular location: GO_0005654
comment: Reactome DB_ID: 6234182
display name: NTHL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9MA35
data source: Provenance1
name: Q9MA35
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref21621
feature: FragmentFeature6505
cellular location: GO_0005654
comment: Reactome DB_ID: 6234184
display name: NTHL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q3EBA6
data source: Provenance1
name: Methyl-CpG-binding domain protein 4
name: MBD4 glycosylase
name: Q3EBA6
name: MBD4_HUMAN
xref: UnificationXref21594
feature: FragmentFeature6497
cellular location: GO_0005654
comment: Reactome DB_ID: 6234159
display name: MBD4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8LB76
data source: Provenance1
name: Methyl-CpG-binding domain protein 4
name: MBD4 glycosylase
name: MBD4_HUMAN
name: Q8LB76
xref: UnificationXref21596
feature: FragmentFeature6498
cellular location: GO_0005654
comment: Reactome DB_ID: 6234161
display name: MBD4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4JFQ3
data source: Provenance1
name: Methyl-CpG-binding domain protein 4
name: MBD4 glycosylase
name: MBD4_HUMAN
name: F4JFQ3
xref: UnificationXref21598
feature: FragmentFeature6499
cellular location: GO_0005654
comment: Reactome DB_ID: 6234163
display name: MBD4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SFC1
data source: Provenance1
name: Q9SFC1
name: Methyl-CpG-binding domain protein 4
name: MBD4 glycosylase
name: MBD4_HUMAN
xref: UnificationXref21600
feature: FragmentFeature6500
cellular location: GO_0005654
comment: Reactome DB_ID: 6234165
display name: MBD4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q0IGK1
data source: Provenance1
name: Methyl-CpG-binding domain protein 4
name: MBD4 glycosylase
name: MBD4_HUMAN
name: Q0IGK1
xref: UnificationXref21602
feature: FragmentFeature6501
cellular location: GO_0005654
comment: Reactome DB_ID: 6234167
display name: MBD4

Homologues of NTHL1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8LF57
member physical entity: B9DFZ0
xref: UnificationXref21628
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6234191

The canonical retinoid cycle in rods (twilight vision)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction552
evidence: Evidence884
xref: UnificationXref10492
xref: UnificationXref10491
xref: RelationshipXref545
pathway order: PathwayStep860
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

UniProt:F4JPD8
type: ProteinReference
xref: UnificationXref16421
organism: http://identifiers.org/taxonomy/3702

Q9ZV43
type: Protein
entity reference: Q9ZV43
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA excision repair protein ERCC-6
name: Cockayne syndrome protein CSB
name: Excision repair protein ERCC-6 (Cockayne syndrome protein CSB)
name: CSB protein
xref: UnificationXref21983
feature: FragmentFeature6544
cellular location: GO_0005654
comment: Reactome DB_ID: 6234098
display name: ERCC6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9MA98
data source: Provenance1
name: ERCC1, DNA excision repair protein
name: Q9MA98
name: DNA excision repair protein ERCC-1
xref: UnificationXref21947
feature: FragmentFeature6543
cellular location: GO_0005654
comment: Reactome DB_ID: 6232602
display name: ERCC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LKI5
data source: Provenance1
name: XPF protein
name: DNA excision repair protein ERCC-4
name: Q9LKI5
name: DNA-repair protein complementing XP-F cell
name: DNA-repair protein complementing XP-F cell (Xeroderma pigmentosum group F complementing protein) (DNA excision repair protein ERCC-4)
name: Xeroderma pigmentosum group F complementing protein
xref: UnificationXref21945
feature: FragmentFeature6542
cellular location: GO_0005654
comment: Reactome DB_ID: 6232606
display name: ERCC4

DDB1, DNA damage binding protein 1
type: Protein
entity reference: Q84R20
data source: Provenance1
name: Q84R20
name: DNA damage binding protein 1
name: XAP-1
name: Damage-specific DNA binding protein 1
name: DDB p127 subunit
name: DDBa
name: Note: the coordinates are copied over from Homo sapiens.
name: Xeroderma pigmentosum group E complementing protein
name: X- associated protein 1
name: UV-damaged DNA-binding protein 1
name: XPCe
name: UV-DDB 1
xref: UnificationXref21936
feature: FragmentFeature6541
cellular location: GO_0005654
comment: Reactome DB_ID: 6232593
display name: DDB1

UniProt:F4K1D3
type: ProteinReference
xref: UnificationXref1570
organism: http://identifiers.org/taxonomy/3702

DDB1, DNA damage binding protein 1
type: Protein
entity reference: Q9M0V3
data source: Provenance1
name: DNA damage binding protein 1
name: XAP-1
name: Damage-specific DNA binding protein 1
name: DDB p127 subunit
name: DDBa
name: Note: the coordinates are copied over from Homo sapiens.
name: Xeroderma pigmentosum group E complementing protein
name: X- associated protein 1
name: Q9M0V3
name: UV-damaged DNA-binding protein 1
name: XPCe
name: UV-DDB 1
xref: UnificationXref21934
feature: FragmentFeature6540
cellular location: GO_0005654
comment: Reactome DB_ID: 6232591
display name: DDB1

DDB1, DNA damage binding protein 1
type: Protein
entity reference: O49552
data source: Provenance1
name: DNA damage binding protein 1
name: XAP-1
name: Damage-specific DNA binding protein 1
name: DDB p127 subunit
name: DDBa
name: Note: the coordinates are copied over from Homo sapiens.
name: Xeroderma pigmentosum group E complementing protein
name: X- associated protein 1
name: O49552
name: UV-damaged DNA-binding protein 1
name: XPCe
name: UV-DDB 1
xref: UnificationXref21932
feature: FragmentFeature6539
cellular location: GO_0005654
comment: Reactome DB_ID: 6232587
display name: DDB1

DDB1, DNA damage binding protein 1
type: Protein
entity reference: F4J8K5
data source: Provenance1
name: DNA damage binding protein 1
name: XAP-1
name: F4J8K5
name: Damage-specific DNA binding protein 1
name: DDB p127 subunit
name: DDBa
name: Note: the coordinates are copied over from Homo sapiens.
name: Xeroderma pigmentosum group E complementing protein
name: X- associated protein 1
name: UV-damaged DNA-binding protein 1
name: XPCe
name: UV-DDB 1
xref: UnificationXref21930
feature: FragmentFeature6538
cellular location: GO_0005654
comment: Reactome DB_ID: 6232583
display name: DDB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8L6Z7
data source: Provenance1
name: Q8L6Z7
name: DNA excision repair protein ERCC-5
name: DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G complementing protein) (DNA excision repair protein ERCC-5)
name: Xeroderma pigmentosum group G complementing protein
name: DNA-repair protein complementing XP-G cells
name: ERCC5 or XPGC
name: XPG protein
xref: UnificationXref21928
feature: FragmentFeature6537
cellular location: GO_0005654
comment: Reactome DB_ID: 6232503
display name: ERCC5

Homologues of DDB1
type: Protein
data source: Provenance1
member physical entity: DDB1, DNA damage binding protein 1
xref: UnificationXref21937
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6232594

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

Q6NQ88
type: Protein
entity reference: Q6NQ88
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UV-DDB 2
name: Damage-specific DNA binding protein 2
name: DNA damage binding protein 2
name: DDB2, DNA damage binding protein 2
name: UV-damaged DNA-binding protein 2
name: DDBb
name: DDB p48 subunit
xref: UnificationXref21926
feature: FragmentFeature6536
cellular location: GO_0005654
comment: Reactome DB_ID: 6232579
display name: DDB2

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

http://identifiers.org/pubmed/7913309
type: PublicationXref
id: 7913309
author: Rokosz, LL
author: Cueto, MA
author: Butkiewicz, EA
author: Hermes, JD
author: Boulton, DA
author: Sanyal, G
author: Lachance, PA
db: Pubmed
title: Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
source: Arch Biochem Biophys 312:1-13
year: 1994

http://identifiers.org/pubmed/8033208
type: PublicationXref
id: 8033208
author: Shirodkar, S
author: Kaelin WG, Jr
author: Livingston, DM
author: Ewen, ME
author: Krek, W
author: Arany, Z
db: Pubmed
title: Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
source: Cell 78:161-72
year: 1994

UniProt:F4JPD9
type: ProteinReference
xref: UnificationXref16415
organism: http://identifiers.org/taxonomy/3702

Q7Y1C4
type: Protein
entity reference: Q7Y1C4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Breast cancer type 2 susceptibility protein
xref: UnificationXref21850
feature: FragmentFeature6521
cellular location: GO_0005654
comment: Reactome DB_ID: 6233671
display name: BRCA2

SequenceSite12186
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7Y1C5
data source: Provenance1
name: Breast cancer type 2 susceptibility protein
name: Q7Y1C5
xref: UnificationXref21848
feature: FragmentFeature6520
cellular location: GO_0005654
comment: Reactome DB_ID: 6233667
display name: BRCA2

SequenceSite12185
type: SequenceSite
position status: EQUAL
sequence position: 321

Homologues of BRCA2
type: Protein
data source: Provenance1
member physical entity: Q7Y1C4
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21859
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6233680

SequenceSite12188
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9SL02
data source: Provenance1
name: Q9SL02
xref: UnificationXref21837
feature: FragmentFeature6519
cellular location: GO_0005654
comment: Reactome DB_ID: 6233170
display name: RAD50

SequenceSite12187
type: SequenceSite
position status: EQUAL
sequence position: 321

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4JGU5
data source: Provenance1
name: Breast cancer type 2 susceptibility protein
name: F4JGU5
xref: UnificationXref21858
feature: FragmentFeature6525
cellular location: GO_0005654
comment: Reactome DB_ID: 6233679
display name: BRCA2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9M164
data source: Provenance1
name: Q9M164
name: Breast cancer type 2 susceptibility protein
xref: UnificationXref21856
feature: FragmentFeature6524
cellular location: GO_0005654
comment: Reactome DB_ID: 6233677
display name: BRCA2

SequenceSite12189
type: SequenceSite
position status: EQUAL
sequence position: 321

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0Z3E3
data source: Provenance1
name: C0Z3E3
name: Breast cancer type 2 susceptibility protein
xref: UnificationXref21854
feature: FragmentFeature6523
cellular location: GO_0005654
comment: Reactome DB_ID: 6233675
display name: BRCA2

Ketone body metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 254888.1
pathway component: REACT 252096.1
evidence: Evidence1153
xref: RelationshipXref837
xref: UnificationXref12790
xref: UnificationXref12789
pathway order: PathwayStep1126
pathway order: PathwayStep1128
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84W87
data source: Provenance1
name: Breast cancer type 2 susceptibility protein
name: Q84W87
xref: UnificationXref21852
feature: FragmentFeature6522
cellular location: GO_0005654
comment: Reactome DB_ID: 6233673
display name: BRCA2

SequenceSite12180
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P94102
data source: Provenance1
name: P94102
name: HsRAD51
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: hRAD51
xref: UnificationXref21861
feature: FragmentFeature6526
cellular location: GO_0005654
comment: Reactome DB_ID: 6233663
display name: RAD51

SequenceSite12182
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite12181
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12184
type: SequenceSite
position status: EQUAL
sequence position: 993

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

SequenceSite12183
type: SequenceSite
position status: EQUAL
sequence position: 321

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

Signaling by FGFR1 mutants
type: Pathway
data source: Provenance1
pathway component: Signaling by FGFR1 fusion mutants
evidence: Evidence833
xref: UnificationXref10170
xref: UnificationXref10169
pathway order: PathwayStep809
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

HSF1 activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction264
pathway component: BiochemicalReaction265
pathway component: BiochemicalReaction262
pathway component: BiochemicalReaction263
pathway component: BiochemicalReaction266
pathway component: BiochemicalReaction267
evidence: Evidence427
xref: UnificationXref5335
xref: UnificationXref5334
xref: RelationshipXref205
pathway order: PathwayStep404
pathway order: PathwayStep409
pathway order: PathwayStep405
pathway order: PathwayStep406
pathway order: PathwayStep407
pathway order: PathwayStep408
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

MRE11 homolog 1
type: Protein
entity reference: Q9XGM2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Double-strand break repair protein MRE11A
name: Q9XGM2
xref: UnificationXref21835
feature: FragmentFeature6518
cellular location: GO_0005654
comment: Reactome DB_ID: 6233174
display name: MRE11A

Homologues of RAD23B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref21916
cellular location: GO_0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 6232493

SequenceSite12199
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8W489
data source: Provenance1
name: XPC protein
name: xeroderma pigmentosum, complementation group C
name: Xeroderma pigmentosum group C complementing protein
name: DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C complementing protein) (P125)
name: p125
name: DNA-repair protein complementing XP-C cells
name: Q8W489
xref: UnificationXref21903
feature: FragmentFeature6529
cellular location: GO_0005654
comment: Reactome DB_ID: 6232497
display name: XPC

SequenceSite12198
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: F4KCN6
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: HHR23B
name: F4KCN6
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21907
feature: FragmentFeature6531
cellular location: GO_0005654
comment: Reactome DB_ID: 6232476
display name: P58

SequenceSite12197
type: SequenceSite
position status: EQUAL
sequence position: 321

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9LF19
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: HHR23B
name: Q9LF19
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21905
feature: FragmentFeature6530
cellular location: GO_0005654
comment: Reactome DB_ID: 6232474
display name: P58

SequenceSite12196
type: SequenceSite
position status: EQUAL
sequence position: 993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84L31
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: HHR23B
name: Q84L31
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21911
feature: FragmentFeature6533
cellular location: GO_0005654
comment: Reactome DB_ID: 6232484
display name: P58

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84L30
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: HHR23B
name: Q84L30
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21909
feature: FragmentFeature6532
cellular location: GO_0005654
comment: Reactome DB_ID: 6232480
display name: P58

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84L32
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: Q84L32
name: HHR23B
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21915
feature: FragmentFeature6535
cellular location: GO_0005654
comment: Reactome DB_ID: 6232492
display name: P58

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q84L33
data source: Provenance1
name: RAD23 homolog B (S. cerevisiae)
name: HR23B, RAD23B homolog protein
name: RAD23B
name: Q84L33
name: HHR23B
name: UV excision repair protein RAD23 homolog B
name: XP-C repair complementing complex 58 kDa protein
name: UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58)
xref: UnificationXref21913
feature: FragmentFeature6534
cellular location: GO_0005654
comment: Reactome DB_ID: 6232488
display name: P58

SequenceSite12191
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12190
type: SequenceSite
position status: EQUAL
sequence position: 993

http://identifiers.org/pubmed/9852097
type: PublicationXref
id: 9852097
author: Kerr, TA
author: Russell, DW
author: Li, WP
author: Sakai, J
author: Lund, EG
db: Pubmed
title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
source: J Biol Chem 273:34316-27
year: 1998

SequenceSite12195
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12194
type: SequenceSite
position status: EQUAL
sequence position: 993

SequenceSite12193
type: SequenceSite
position status: EQUAL
sequence position: 321

SequenceSite12192
type: SequenceSite
position status: EQUAL
sequence position: 993

http://identifiers.org/pubmed/12176987
type: PublicationXref
id: 12176987
author: Tanabe, K
author: Tanaka, AR
author: Ueda, K
author: Morita, M
author: Kurisu, M
author: Matsuo, M
author: Kasiwayama, Y
author: Kioka, N
author: Imanaka, T
author: Amachi, T
db: Pubmed
title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
source: J Biol Chem 277:40142-7
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9FQ08
data source: Provenance1
name: Q9FQ08
name: ATP-dependent DNA helicase II, 70 kDa subunit
name: CTC75
name: XRCC6
name: CTCBF
name: Thyroid-lupus autoantigen
name: 70 kDa subunit of Ku antigen
name: TLAA
name: Lupus Ku autoantigen protein p70
name: CTC box binding factor 75 kDa subunit
xref: UnificationXref21891
feature: FragmentFeature6527
cellular location: GO_0005654
comment: Reactome DB_ID: 6233404
display name: Ku70

XRCC5
type: Protein
entity reference: Q9FQ09
data source: Provenance1
name: DNA-repair protein XRCC5
name: 86 kDa subunit of Ku antigen
name: Lupus Ku autoantigen protein p86
name: Nuclear factor IV
name: TLAA
name: CTC box binding factor 85 kDa subunit
name: Note: the coordinates are copied over from Homo sapiens.
name: Thyroid- lupus autoantigen
name: ATP-dependent DNA helicase II, 80 kDa subunit
name: Q9FQ09
name: Ku80
name: CTCBF
name: CTC85
xref: UnificationXref21893
feature: FragmentFeature6528
cellular location: GO_0005654
comment: Reactome DB_ID: 6233408
display name: Ku86

http://identifiers.org/pubmed/7816143
type: PublicationXref
id: 7816143
author: Glover, JN
author: Harrison, SC
db: Pubmed
title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
source: Nature 373:257-61
year: 1995

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

http://identifiers.org/pubmed/20154325
type: PublicationXref
id: 20154325
author: Beese, Lorena S
author: Tsai, Miaw-Sheue
author: Genschel, Jochen
author: Modrich, Paul
author: Iyer, Ravi R
author: Pluciennik, Anna
db: Pubmed
title: MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta
source: J. Biol. Chem. 285:11730-9
year: 2010

http://identifiers.org/pubmed/12176931
type: PublicationXref
id: 12176931
author: Lamond, AI
author: Ryder, U
author: Rappsilber, J
author: Mann, M
db: Pubmed
title: Large-scale proteomic analysis of the human spliceosome.
source: Genome Res 12:1231-45
year: 2002

http://identifiers.org/pubmed/11274057
type: PublicationXref
id: 11274057
author: Jiricny, J
author: Kleczkowska, H E
author: Lettieri, T
author: Marra, G
db: Pubmed
title: hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
source: Genes Dev. 15:724-36
year: 2001

http://identifiers.org/pubmed/12496762
type: PublicationXref
id: 12496762
author: Yamaguchi, Yu
author: Nguyen, Louis N
author: Murai, Keith K
author: Pasquale, Elena B
author: Irie, Fumitoshi
db: Pubmed
title: Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
source: Nat. Neurosci. 6:153-60
year: 2003

http://identifiers.org/pubmed/12807903
type: PublicationXref
id: 12807903
author: Nagai, M
author: Sudol, M
author: Navin, NE
author: Komuro, A
db: Pubmed
title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
source: J Biol Chem 278:33334-41
year: 2003

Assembly of the pre-replicative complex
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction177
pathway component: BiochemicalReaction175
pathway component: REACT 250858.1
pathway component: REACT 255146.1
evidence: Evidence291
xref: UnificationXref4069
xref: UnificationXref4068
pathway order: PathwayStep277
pathway order: PathwayStep278
pathway order: PathwayStep281
pathway order: PathwayStep280
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

Molybdopterin
type: SmallMoleculeReference
name: Molybdopterin [ChEBI:6969]
xref: UnificationXref11571

Stoichiometry8
type: Stoichiometry
physical entity: Protein113
stoichiometric coefficient: 1.0

Stoichiometry9
type: Stoichiometry
physical entity: Protein117
stoichiometric coefficient: 1.0

Stoichiometry4
type: Stoichiometry
physical entity: Protein105
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: Protein108
stoichiometric coefficient: 1.0

Stoichiometry6
type: Stoichiometry
physical entity: Protein109
stoichiometric coefficient: 1.0

Stoichiometry7
type: Stoichiometry
physical entity: Protein112
stoichiometric coefficient: 1.0

Stoichiometry1
type: Stoichiometry
physical entity: SmallMolecule2
stoichiometric coefficient: 2.0

Stoichiometry2
type: Stoichiometry
physical entity: SmallMolecule23
stoichiometric coefficient: 2.0

Stoichiometry3
type: Stoichiometry
physical entity: Protein104
stoichiometric coefficient: 1.0

Golgi membrane
type: CellularLocationVocabulary
xref: UnificationXref4686

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

SequenceSite1810
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1811
type: SequenceSite
position status: EQUAL
sequence position: 193

SequenceSite1812
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1813
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite1814
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12210
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12213
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12214
type: SequenceSite
position status: EQUAL
sequence position: 445

SequenceSite12211
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12212
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12207
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12206
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12205
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12204
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12209
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12208
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite1805
type: SequenceSite
position status: EQUAL
sequence position: 808

SequenceSite1804
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1807
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite1806
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1809
type: SequenceSite
position status: EQUAL
sequence position: 620

SequenceSite1808
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q94JZ0
type: ProteinReference
xref: UnificationXref19900
organism: http://identifiers.org/taxonomy/3702

SequenceSite1802
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1803
type: SequenceSite
position status: EQUAL
sequence position: 597

SequenceSite1800
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1801
type: SequenceSite
position status: EQUAL
sequence position: 147

SequenceSite12200
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12201
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12202
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite12203
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:F4JQ95
type: ProteinReference
xref: UnificationXref1845
organism: http://identifiers.org/taxonomy/3702

SequenceSite1833
type: SequenceSite
position status: EQUAL
sequence position: 205

SequenceSite1834
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1835
type: SequenceSite
position status: EQUAL
sequence position: 499

SequenceSite1836
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1830
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1831
type: SequenceSite
position status: EQUAL
sequence position: 328

UniProt:Q94JW0
type: ProteinReference
xref: UnificationXref20244
organism: http://identifiers.org/taxonomy/3702

SequenceSite1832
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

SequenceSite1827
type: SequenceSite
position status: EQUAL
sequence position: 328

SequenceSite1826
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1829
type: SequenceSite
position status: EQUAL
sequence position: 328

SequenceSite1828
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1824
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1825
type: SequenceSite
position status: EQUAL
sequence position: 1050

http://identifiers.org/pubmed/12851482
type: PublicationXref
id: 12851482
author: Poon, RY
author: Woo, RA
db: Pubmed
title: Cyclin-dependent kinases and S phase control in mammalian cells
source: Cell Cycle 2:316-24
year: 2003

SequenceSite1822
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1823
type: SequenceSite
position status: EQUAL
sequence position: 599

SequenceSite1820
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1821
type: SequenceSite
position status: EQUAL
sequence position: 185

UniProt:P24704
type: ProteinReference
xref: UnificationXref1929
organism: http://identifiers.org/taxonomy/3702

SequenceSite1819
type: SequenceSite
position status: EQUAL
sequence position: 824

SequenceSite1818
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1817
type: SequenceSite
position status: EQUAL
sequence position: 824

SequenceSite1816
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1815
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite1850
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1852
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1851
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1854
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1853
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1856
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1855
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1858
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1857
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1848
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1849
type: SequenceSite
position status: EQUAL
sequence position: 465

http://identifiers.org/pubmed/9153422
type: PublicationXref
id: 9153422
author: Batelier, G
author: Soulié, S
author: Melki, R
author: Williams RC, Jr
db: Pubmed
title: Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
source: Biochemistry 36:5817-26
year: 1997

SequenceSite1843
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1842
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1841
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1840
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1847
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1846
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1845
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1844
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1839
type: SequenceSite
position status: EQUAL
sequence position: 465

UniProt:F4JQ51
type: ProteinReference
xref: UnificationXref2265
organism: http://identifiers.org/taxonomy/3702

SequenceSite1837
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite1838
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1870
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1872
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1871
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1878
type: SequenceSite
position status: EQUAL
sequence position: 297

SequenceSite1877
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1879
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1874
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1873
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1876
type: SequenceSite
position status: EQUAL
sequence position: 161

SequenceSite1875
type: SequenceSite
position status: EQUAL
sequence position: 432

UniProt:F4JPW1
type: ProteinReference
xref: UnificationXref8915
organism: http://identifiers.org/taxonomy/3702

Glutamate Neurotransmitter Release Cycle
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction413
evidence: Evidence637
xref: RelationshipXref334
xref: UnificationXref8142
xref: UnificationXref8143
pathway order: PathwayStep615
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite1861
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1860
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1869
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1868
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1867
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1866
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1865
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1864
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1863
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1862
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1859
type: SequenceSite
position status: EQUAL
sequence position: 432

SequenceSite1897
type: SequenceSite
position status: EQUAL
sequence position: 9

SequenceSite1898
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1895
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12290
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite1896
type: SequenceSite
position status: EQUAL
sequence position: 419

SequenceSite12291
type: SequenceSite
position status: EQUAL
sequence position: 1

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction81
pathway component: BiochemicalReaction82
pathway component: BiochemicalReaction83
evidence: Evidence138
xref: UnificationXref2686
xref: UnificationXref2685
pathway order: PathwayStep128
pathway order: PathwayStep127
pathway order: PathwayStep126
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: http://identifiers.org/taxonomy/3702

SequenceSite12292
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12293
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1899
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite12294
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12295
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12296
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite1890
type: SequenceSite
position status: EQUAL
sequence position: 425

SequenceSite12297
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12298
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12299
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1893
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1894
type: SequenceSite
position status: EQUAL
sequence position: 425

SequenceSite1891
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1892
type: SequenceSite
position status: EQUAL
sequence position: 425

SequenceSite1884
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite1885
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1886
type: SequenceSite
position status: EQUAL
sequence position: 425

http://identifiers.org/pubmed/10092594
type: PublicationXref
id: 10092594
author: Jones, JM
author: Gould, SJ
author: Geraghty, MT
author: Nau, K
author: Erdmann, R
db: Pubmed
title: Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
source: J Biol Chem 274:9216-23
year: 1999

SequenceSite1887
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12282
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite1888
type: SequenceSite
position status: EQUAL
sequence position: 425

SequenceSite12283
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1889
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite12280
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite12281
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12286
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12287
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite12284
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite12285
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1880
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite1881
type: SequenceSite
position status: EQUAL
sequence position: 6

SequenceSite12288
type: SequenceSite
position status: EQUAL
sequence position: 202