CHEMBL_MEC_1664
type: Mechanism
chembl id: CHEMBL_MEC_1664
has molecule: CHEMBL22
has target: CHEMBL2364669
mechanism description: Bacterial dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_340
type: Mechanism
chembl id: CHEMBL_MEC_340
has molecule: CHEMBL35
has target: CHEMBL1874
mechanism description: Sodium-(potassium)-chloride cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1905
type: Mechanism
chembl id: CHEMBL_MEC_1905
has molecule: CHEMBL5
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4555
type: Mechanism
chembl id: CHEMBL_MEC_4555
has molecule: CHEMBL6318
has target: CHEMBL2093866
mechanism description: Estrogen receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_902
type: Mechanism
chembl id: CHEMBL_MEC_902
has molecule: CHEMBL405
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_687
type: Mechanism
chembl id: CHEMBL_MEC_687
has molecule: CHEMBL405
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1588
type: Mechanism
chembl id: CHEMBL_MEC_1588
has molecule: CHEMBL407
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel allosteric antagonist
mechanism action type: ALLOSTERIC ANTAGONIST

CHEMBL_MEC_1222
type: Mechanism
chembl id: CHEMBL_MEC_1222
has molecule: CHEMBL6622
has target: CHEMBL2111348
has binding site: CHEMBL BS 2654
mechanism description: Soluble guanylate cyclase activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_41
type: Mechanism
chembl id: CHEMBL_MEC_41
has molecule: CHEMBL14
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1320
type: Mechanism
chembl id: CHEMBL_MEC_1320
has molecule: CHEMBL409
has target: CHEMBL1871
mechanism description: Androgen Receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1987
type: Mechanism
chembl id: CHEMBL_MEC_1987
has molecule: CHEMBL16
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_17
type: Mechanism
chembl id: CHEMBL_MEC_17
has molecule: CHEMBL20
has target: CHEMBL261
mechanism description: Carbonic anhydrase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_959
type: Mechanism
chembl id: CHEMBL_MEC_959
has molecule: CHEMBL20
has target: CHEMBL3729
mechanism description: Carbonic anhydrase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_928
type: Mechanism
chembl id: CHEMBL_MEC_928
has molecule: CHEMBL20
has target: CHEMBL3242
mechanism description: Carbonic anhydrase XII inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_92
type: Mechanism
chembl id: CHEMBL_MEC_92
has molecule: CHEMBL20
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_867
type: Mechanism
chembl id: CHEMBL_MEC_867
has molecule: CHEMBL411
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_391
type: Mechanism
chembl id: CHEMBL_MEC_391
has molecule: CHEMBL433
has target: CHEMBL1911
mechanism description: Succinate semialdehyde dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1658
type: Mechanism
chembl id: CHEMBL_MEC_1658
has molecule: CHEMBL453
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1660
type: Mechanism
chembl id: CHEMBL_MEC_1660
has molecule: CHEMBL439
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1648
type: Mechanism
chembl id: CHEMBL_MEC_1648
has molecule: CHEMBL21
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1610
type: Mechanism
chembl id: CHEMBL_MEC_1610
has molecule: CHEMBL450
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1599
type: Mechanism
chembl id: CHEMBL_MEC_1599
has molecule: CHEMBL454
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1590
type: Mechanism
chembl id: CHEMBL_MEC_1590
has molecule: CHEMBL451
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1797
type: Mechanism
chembl id: CHEMBL_MEC_1797
has molecule: CHEMBL1201558
has target: CHEMBL2364170
mechanism description: Interferon alpha/beta receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2120
type: Mechanism
chembl id: CHEMBL_MEC_2120
has molecule: CHEMBL1201516
mechanism description: Unknown

CHEMBL_MEC_237
type: Mechanism
chembl id: CHEMBL_MEC_237
has molecule: CHEMBL1201535
has target: CHEMBL229
mechanism description: Alpha-1a adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_877
type: Mechanism
chembl id: CHEMBL_MEC_877
has molecule: CHEMBL1201535
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1653
type: Mechanism
chembl id: CHEMBL_MEC_1653
has molecule: CHEMBL443
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_338
type: Mechanism
chembl id: CHEMBL_MEC_338
has molecule: CHEMBL456
has target: CHEMBL1874
mechanism description: Sodium-(potassium)-chloride cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2143
type: Mechanism
chembl id: CHEMBL_MEC_2143
has molecule: CHEMBL52
mechanism description: Unknown

CHEMBL_MEC_1466
type: Mechanism
chembl id: CHEMBL_MEC_1466
has molecule: CHEMBL465
has target: CHEMBL218
mechanism description: Cannabinoid CB1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_526
type: Mechanism
chembl id: CHEMBL_MEC_526
has molecule: CHEMBL488
has target: CHEMBL1978
mechanism description: Cytochrome P450 19A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_758
type: Mechanism
chembl id: CHEMBL_MEC_758
has molecule: CHEMBL488
has target: CHEMBL2033
mechanism description: Cytochrome P450 11A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_830
type: Mechanism
chembl id: CHEMBL_MEC_830
has molecule: CHEMBL57
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_624
type: Mechanism
chembl id: CHEMBL_MEC_624
has molecule: CHEMBL479
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2019
type: Mechanism
chembl id: CHEMBL_MEC_2019
has molecule: CHEMBL479
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_606
type: Mechanism
chembl id: CHEMBL_MEC_606
has molecule: CHEMBL479
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_500
type: Mechanism
chembl id: CHEMBL_MEC_500
has molecule: CHEMBL473
has target: CHEMBL240
mechanism description: HERG blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1868
type: Mechanism
chembl id: CHEMBL_MEC_1868
has molecule: CHEMBL476
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1085
type: Mechanism
chembl id: CHEMBL_MEC_1085
has molecule: CHEMBL480
has target: CHEMBL2095173
has binding site: CHEMBL BS 2651
mechanism description: Potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2133
type: Mechanism
chembl id: CHEMBL_MEC_2133
has molecule: CHEMBL61
mechanism description: Unknown

CHEMBL_MEC_4147
type: Mechanism
chembl id: CHEMBL_MEC_4147
has molecule: CHEMBL9960
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2206
type: Mechanism
chembl id: CHEMBL_MEC_2206
has molecule: CHEMBL74
mechanism description: Unknown

CHEMBL_MEC_4567
type: Mechanism
chembl id: CHEMBL_MEC_4567
has molecule: CHEMBL10041
has target: CHEMBL4245
mechanism description: Estrogen-related receptor gamma antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4566
type: Mechanism
chembl id: CHEMBL_MEC_4566
has molecule: CHEMBL10041
has target: CHEMBL2093866
mechanism description: Estrogen receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_331
type: Mechanism
chembl id: CHEMBL_MEC_331
has molecule: CHEMBL499
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1365
type: Mechanism
chembl id: CHEMBL_MEC_1365
has molecule: CHEMBL499
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1399
type: Mechanism
chembl id: CHEMBL_MEC_1399
has molecule: CHEMBL496
has target: CHEMBL2364678
mechanism description: Bacterial enoyl-[acyl-carrier-protein] reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_665
type: Mechanism
chembl id: CHEMBL_MEC_665
has molecule: CHEMBL494
has target: CHEMBL1995
mechanism description: Prostanoid IP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_900
type: Mechanism
chembl id: CHEMBL_MEC_900
has molecule: CHEMBL501
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_688
type: Mechanism
chembl id: CHEMBL_MEC_688
has molecule: CHEMBL501
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1872
type: Mechanism
chembl id: CHEMBL_MEC_1872
has molecule: CHEMBL11359
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1446
type: Mechanism
chembl id: CHEMBL_MEC_1446
has molecule: CHEMBL91
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1859
type: Mechanism
chembl id: CHEMBL_MEC_1859
has molecule: CHEMBL515
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_190
type: Mechanism
chembl id: CHEMBL_MEC_190
has molecule: CHEMBL98
has target: CHEMBL1829
mechanism description: Histone deacetylase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1489
type: Mechanism
chembl id: CHEMBL_MEC_1489
has molecule: CHEMBL98
has target: CHEMBL1937
mechanism description: Histone deacetylase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_121
type: Mechanism
chembl id: CHEMBL_MEC_121
has molecule: CHEMBL98
has target: CHEMBL325
mechanism description: Histone deacetylase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_307
type: Mechanism
chembl id: CHEMBL_MEC_307
has molecule: CHEMBL98
has target: CHEMBL1865
mechanism description: Histone deacetylase 6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1205
type: Mechanism
chembl id: CHEMBL_MEC_1205
has molecule: CHEMBL101
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1442
type: Mechanism
chembl id: CHEMBL_MEC_1442
has molecule: CHEMBL104
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1018
type: Mechanism
chembl id: CHEMBL_MEC_1018
has molecule: CHEMBL103
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1972
type: Mechanism
chembl id: CHEMBL_MEC_1972
has molecule: CHEMBL108
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_42
type: Mechanism
chembl id: CHEMBL_MEC_42
has molecule: CHEMBL550
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_2369
type: Mechanism
chembl id: CHEMBL_MEC_2369
has molecule: CHEMBL550
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1172
type: Mechanism
chembl id: CHEMBL_MEC_1172
has molecule: CHEMBL112
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2227
type: Mechanism
chembl id: CHEMBL_MEC_2227
has molecule: CHEMBL112
has target: CHEMBL4794
mechanism description: Vanilloid receptor opener
mechanism action type: OPENER

CHEMBL_MEC_2226
type: Mechanism
chembl id: CHEMBL_MEC_2226
has molecule: CHEMBL112
has target: CHEMBL2243
mechanism description: Anandamide amidohydrolase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1106
type: Mechanism
chembl id: CHEMBL_MEC_1106
has molecule: CHEMBL107
has target: CHEMBL2095182
has binding site: CHEMBL BS 2628
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_392
type: Mechanism
chembl id: CHEMBL_MEC_392
has molecule: CHEMBL109
has target: CHEMBL1911
mechanism description: Succinate semialdehyde dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2031
type: Mechanism
chembl id: CHEMBL_MEC_2031
has molecule: CHEMBL15891
has target: CHEMBL2364024
mechanism description: GABA-A receptor negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_2032
type: Mechanism
chembl id: CHEMBL_MEC_2032
has molecule: CHEMBL15891
has target: CHEMBL2364025
mechanism description: GABA-A receptor negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1302
type: Mechanism
chembl id: CHEMBL_MEC_1302
has molecule: CHEMBL559
has target: CHEMBL2111462
mechanism description: Thyroid hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5403
type: Mechanism
chembl id: CHEMBL_MEC_5403
has molecule: CHEMBL23261
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5404
type: Mechanism
chembl id: CHEMBL_MEC_5404
has molecule: CHEMBL23261
has target: CHEMBL1785
mechanism description: Endothelin receptor ET-B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1463
type: Mechanism
chembl id: CHEMBL_MEC_1463
has molecule: CHEMBL622
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2254
type: Mechanism
chembl id: CHEMBL_MEC_2254
has molecule: CHEMBL139
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2067
type: Mechanism
chembl id: CHEMBL_MEC_2067
has molecule: CHEMBL126
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1659
type: Mechanism
chembl id: CHEMBL_MEC_1659
has molecule: CHEMBL700
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1541
type: Mechanism
chembl id: CHEMBL_MEC_1541
has molecule: CHEMBL24828
has target: CHEMBL2363043
mechanism description: Ephrin receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1034
type: Mechanism
chembl id: CHEMBL_MEC_1034
has molecule: CHEMBL24828
has target: CHEMBL4128
mechanism description: Tyrosine-protein kinase TIE-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_683
type: Mechanism
chembl id: CHEMBL_MEC_683
has molecule: CHEMBL24828
has target: CHEMBL267
mechanism description: Tyrosine-protein kinase SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1265
type: Mechanism
chembl id: CHEMBL_MEC_1265
has molecule: CHEMBL24828
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1519
type: Mechanism
chembl id: CHEMBL_MEC_1519
has molecule: CHEMBL24828
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1546
type: Mechanism
chembl id: CHEMBL_MEC_1546
has molecule: CHEMBL24828
has target: CHEMBL2363049
mechanism description: Epidermal growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_984
type: Mechanism
chembl id: CHEMBL_MEC_984
has molecule: CHEMBL24828
has target: CHEMBL4601
mechanism description: Tyrosine-protein kinase BRK inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5140
type: Mechanism
chembl id: CHEMBL_MEC_5140
has molecule: CHEMBL17350
has target: CHEMBL1907603
mechanism description: Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1921
type: Mechanism
chembl id: CHEMBL_MEC_1921
has molecule: CHEMBL940
has target: CHEMBL2363032
has binding site: CHEMBL BS 2657
mechanism description: Voltage-gated calcium channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_2215
type: Mechanism
chembl id: CHEMBL_MEC_2215
has molecule: CHEMBL706
mechanism description: Unknown

CHEMBL_MEC_495
type: Mechanism
chembl id: CHEMBL_MEC_495
has molecule: CHEMBL1201489
has target: CHEMBL1965
mechanism description: Melanocortin receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1068
type: Mechanism
chembl id: CHEMBL_MEC_1068
has molecule: CHEMBL1201468
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1438
type: Mechanism
chembl id: CHEMBL_MEC_1438
has molecule: CHEMBL685
has target: CHEMBL2364705
has binding site: CHEMBL BS 2632
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1434
type: Mechanism
chembl id: CHEMBL_MEC_1434
has molecule: CHEMBL685
has target: CHEMBL2364704
has binding site: CHEMBL BS 2631
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_196
type: Mechanism
chembl id: CHEMBL_MEC_196
has molecule: CHEMBL728
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1193
type: Mechanism
chembl id: CHEMBL_MEC_1193
has molecule: CHEMBL751
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1609
type: Mechanism
chembl id: CHEMBL_MEC_1609
has molecule: CHEMBL591
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1571
type: Mechanism
chembl id: CHEMBL_MEC_1571
has molecule: CHEMBL628
has target: CHEMBL2363066
mechanism description: 3',5'-cyclic phosphodiesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1211
type: Mechanism
chembl id: CHEMBL_MEC_1211
has molecule: CHEMBL628
has target: CHEMBL2094257
mechanism description: Adenosine A2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1824
type: Mechanism
chembl id: CHEMBL_MEC_1824
has molecule: CHEMBL137
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1545
type: Mechanism
chembl id: CHEMBL_MEC_1545
has molecule: CHEMBL141
has target: CHEMBL2363047
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_834
type: Mechanism
chembl id: CHEMBL_MEC_834
has molecule: CHEMBL141
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1926
type: Mechanism
chembl id: CHEMBL_MEC_1926
has molecule: CHEMBL141
has target: CHEMBL2362994
mechanism description: DNA polymerase/reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1543
type: Mechanism
chembl id: CHEMBL_MEC_1543
has molecule: CHEMBL141
has target: CHEMBL2363048
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1544
type: Mechanism
chembl id: CHEMBL_MEC_1544
has molecule: CHEMBL141
has target: CHEMBL2363046
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1597
type: Mechanism
chembl id: CHEMBL_MEC_1597
has molecule: CHEMBL661
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5057
type: Mechanism
chembl id: CHEMBL_MEC_5057
has molecule: CHEMBL22055
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1974
type: Mechanism
chembl id: CHEMBL_MEC_1974
has molecule: CHEMBL698
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2153
type: Mechanism
chembl id: CHEMBL_MEC_2153
has molecule: CHEMBL720
mechanism description: Unknown

CHEMBL_MEC_5646
type: Mechanism
chembl id: CHEMBL_MEC_5646
has molecule: CHEMBL27759
has target: CHEMBL2093865
mechanism description: Histone deacetylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1956
type: Mechanism
chembl id: CHEMBL_MEC_1956
has molecule: CHEMBL744
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1861
type: Mechanism
chembl id: CHEMBL_MEC_1861
has molecule: CHEMBL671
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_440
type: Mechanism
chembl id: CHEMBL_MEC_440
has molecule: CHEMBL16694
has target: CHEMBL1930
mechanism description: Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_790
type: Mechanism
chembl id: CHEMBL_MEC_790
has molecule: CHEMBL650
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1306
type: Mechanism
chembl id: CHEMBL_MEC_1306
has molecule: CHEMBL701
has target: CHEMBL2111463
mechanism description: GABA-B receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_760
type: Mechanism
chembl id: CHEMBL_MEC_760
has molecule: CHEMBL635
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1447
type: Mechanism
chembl id: CHEMBL_MEC_1447
has molecule: CHEMBL22587
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_194
type: Mechanism
chembl id: CHEMBL_MEC_194
has molecule: CHEMBL567
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1671
type: Mechanism
chembl id: CHEMBL_MEC_1671
has molecule: CHEMBL719
has target: CHEMBL2364671
mechanism description: Isoleucyl-tRNA synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_562
type: Mechanism
chembl id: CHEMBL_MEC_562
has molecule: CHEMBL719
has target: CHEMBL1982
mechanism description: Isoleucyl-tRNA synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1057
type: Mechanism
chembl id: CHEMBL_MEC_1057
has molecule: CHEMBL690
has target: CHEMBL402
mechanism description: HMG-CoA reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_441
type: Mechanism
chembl id: CHEMBL_MEC_441
has molecule: CHEMBL711
has target: CHEMBL1930
mechanism description: Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2184
type: Mechanism
chembl id: CHEMBL_MEC_2184
has molecule: CHEMBL604
mechanism description: Unknown

CHEMBL_MEC_1081
type: Mechanism
chembl id: CHEMBL_MEC_1081
has molecule: CHEMBL1201863
has target: CHEMBL2095173
has binding site: CHEMBL BS 2651
mechanism description: Potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_59
type: Mechanism
chembl id: CHEMBL_MEC_59
has molecule: CHEMBL1201866
has target: CHEMBL1784
mechanism description: Glucagon-like peptide 1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1883
type: Mechanism
chembl id: CHEMBL_MEC_1883
has molecule: CHEMBL803
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1916
type: Mechanism
chembl id: CHEMBL_MEC_1916
has molecule: CHEMBL803
has target: CHEMBL2363042
mechanism description: DNA polymerase (alpha/delta/epsilon) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1893
type: Mechanism
chembl id: CHEMBL_MEC_1893
has molecule: CHEMBL803
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1229
type: Mechanism
chembl id: CHEMBL_MEC_1229
has molecule: CHEMBL802
has target: CHEMBL2095198
has binding site: CHEMBL BS 2655
mechanism description: Sulfonylurea receptor 2, Kir6.2 opener
mechanism action type: OPENER

CHEMBL_MEC_856
type: Mechanism
chembl id: CHEMBL_MEC_856
has molecule: CHEMBL786
has target: CHEMBL206
mechanism description: Estrogen receptor alpha modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4535
type: Mechanism
chembl id: CHEMBL_MEC_4535
has molecule: CHEMBL29919
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4536
type: Mechanism
chembl id: CHEMBL_MEC_4536
has molecule: CHEMBL29919
has target: CHEMBL4478
mechanism description: Voltage-gated N-type calcium channel alpha-1B subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4537
type: Mechanism
chembl id: CHEMBL_MEC_4537
has molecule: CHEMBL29919
has target: CHEMBL4266
mechanism description: Voltage-gated P/Q-type calcium channel alpha-1A subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4534
type: Mechanism
chembl id: CHEMBL_MEC_4534
has molecule: CHEMBL29919
has target: CHEMBL5163
mechanism description: Sodium channel protein type III alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4533
type: Mechanism
chembl id: CHEMBL_MEC_4533
has molecule: CHEMBL29919
has target: CHEMBL4187
mechanism description: Sodium channel protein type II alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1991
type: Mechanism
chembl id: CHEMBL_MEC_1991
has molecule: CHEMBL741
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1865
type: Mechanism
chembl id: CHEMBL_MEC_1865
has molecule: CHEMBL810
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1253
type: Mechanism
chembl id: CHEMBL_MEC_1253
has molecule: CHEMBL783
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_953
type: Mechanism
chembl id: CHEMBL_MEC_953
has molecule: CHEMBL606
has target: CHEMBL3710
mechanism description: Prostanoid EP3 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1254
type: Mechanism
chembl id: CHEMBL_MEC_1254
has molecule: CHEMBL782
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_740
type: Mechanism
chembl id: CHEMBL_MEC_740
has molecule: CHEMBL812
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5876
type: Mechanism
chembl id: CHEMBL_MEC_5876
has molecule: CHEMBL848
has target: CHEMBL3833061
mechanism description: CRL4(CRBN) E3 ubiquitin ligase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1981
type: Mechanism
chembl id: CHEMBL_MEC_1981
has molecule: CHEMBL605
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_909
type: Mechanism
chembl id: CHEMBL_MEC_909
has molecule: CHEMBL796
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_700
type: Mechanism
chembl id: CHEMBL_MEC_700
has molecule: CHEMBL796
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_678
type: Mechanism
chembl id: CHEMBL_MEC_678
has molecule: CHEMBL614
has target: CHEMBL2011
mechanism description: Fatty acid synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2071
type: Mechanism
chembl id: CHEMBL_MEC_2071
has molecule: CHEMBL614
has target: CHEMBL2363965
has binding site: CHEMBL BS 2659
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2216
type: Mechanism
chembl id: CHEMBL_MEC_2216
has molecule: CHEMBL46286
mechanism description: Protein synthesis inhibitor

CHEMBL_MEC_456
type: Mechanism
chembl id: CHEMBL_MEC_456
has molecule: CHEMBL902
has target: CHEMBL1941
mechanism description: Histamine H2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1408
type: Mechanism
chembl id: CHEMBL_MEC_1408
has molecule: CHEMBL734
has target: CHEMBL2364683
mechanism description: Bacterial urease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_483
type: Mechanism
chembl id: CHEMBL_MEC_483
has molecule: CHEMBL917
has target: CHEMBL1952
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5402
type: Mechanism
chembl id: CHEMBL_MEC_5402
has molecule: CHEMBL49429
has target: CHEMBL1790
mechanism description: Vasopressin V2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_755
type: Mechanism
chembl id: CHEMBL_MEC_755
has molecule: CHEMBL771
has target: CHEMBL2030
mechanism description: D-alanylalanine synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1378
type: Mechanism
chembl id: CHEMBL_MEC_1378
has molecule: CHEMBL771
has target: CHEMBL2031
mechanism description: Alanine racemase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5602
type: Mechanism
chembl id: CHEMBL_MEC_5602
has molecule: CHEMBL889
has target: CHEMBL2311221
mechanism description: DNA cross-linking agent
mechanism action type: CROSS-LINKING AGENT

CHEMBL_MEC_202
type: Mechanism
chembl id: CHEMBL_MEC_202
has molecule: CHEMBL908
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_247
type: Mechanism
chembl id: CHEMBL_MEC_247
has molecule: CHEMBL908
has target: CHEMBL234
mechanism description: Dopamine D3 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_632
type: Mechanism
chembl id: CHEMBL_MEC_632
has molecule: CHEMBL908
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_577
type: Mechanism
chembl id: CHEMBL_MEC_577
has molecule: CHEMBL908
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6163
type: Mechanism
chembl id: CHEMBL_MEC_6163
has molecule: CHEMBL48582
has target: CHEMBL2039
mechanism description: Monoamine oxidase B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5591
type: Mechanism
chembl id: CHEMBL_MEC_5591
has molecule: CHEMBL49642
has target: CHEMBL2095182
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_423
type: Mechanism
chembl id: CHEMBL_MEC_423
has molecule: CHEMBL843
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_1178
type: Mechanism
chembl id: CHEMBL_MEC_1178
has molecule: CHEMBL898
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1721
type: Mechanism
chembl id: CHEMBL_MEC_1721
has molecule: CHEMBL44354
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1932
type: Mechanism
chembl id: CHEMBL_MEC_1932
has molecule: CHEMBL847
has target: CHEMBL2366043
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_343
type: Mechanism
chembl id: CHEMBL_MEC_343
has molecule: CHEMBL878
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3877
type: Mechanism
chembl id: CHEMBL_MEC_3877
has molecule: CHEMBL52885
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3878
type: Mechanism
chembl id: CHEMBL_MEC_3878
has molecule: CHEMBL52885
has target: CHEMBL2363074
mechanism description: SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3880
type: Mechanism
chembl id: CHEMBL_MEC_3880
has molecule: CHEMBL52885
has target: CHEMBL2095217
mechanism description: Fibroblast growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3876
type: Mechanism
chembl id: CHEMBL_MEC_3876
has molecule: CHEMBL52885
has target: CHEMBL4722
mechanism description: Serine/threonine-protein kinase Aurora-A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3879
type: Mechanism
chembl id: CHEMBL_MEC_3879
has molecule: CHEMBL52885
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3881
type: Mechanism
chembl id: CHEMBL_MEC_3881
has molecule: CHEMBL52885
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1476
type: Mechanism
chembl id: CHEMBL_MEC_1476
has molecule: CHEMBL880
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1461
type: Mechanism
chembl id: CHEMBL_MEC_1461
has molecule: CHEMBL865
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1614
type: Mechanism
chembl id: CHEMBL_MEC_1614
has molecule: CHEMBL969
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1858
type: Mechanism
chembl id: CHEMBL_MEC_1858
has molecule: CHEMBL852
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1400
type: Mechanism
chembl id: CHEMBL_MEC_1400
has molecule: CHEMBL849
has target: CHEMBL2364678
mechanism description: Bacterial enoyl-[acyl-carrier-protein] reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1622
type: Mechanism
chembl id: CHEMBL_MEC_1622
has molecule: CHEMBL967
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1907
type: Mechanism
chembl id: CHEMBL_MEC_1907
has molecule: CHEMBL850
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1640
type: Mechanism
chembl id: CHEMBL_MEC_1640
has molecule: CHEMBL850
has target: CHEMBL2363076
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1032
type: Mechanism
chembl id: CHEMBL_MEC_1032
has molecule: CHEMBL832
has target: CHEMBL6120
mechanism description: Solute carrier family 22 member 12 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_344
type: Mechanism
chembl id: CHEMBL_MEC_344
has molecule: CHEMBL61593
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2408
type: Mechanism
chembl id: CHEMBL_MEC_2408
has molecule: CHEMBL65375
has target: CHEMBL3106
mechanism description: Thymidine phosphorylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1750
type: Mechanism
chembl id: CHEMBL_MEC_1750
has molecule: CHEMBL976
has target: CHEMBL2363080
mechanism description: Voltage-activated calcium channel beta 2 subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1749
type: Mechanism
chembl id: CHEMBL_MEC_1749
has molecule: CHEMBL976
has target: CHEMBL2363079
mechanism description: Voltage-activated calcium channel beta 1 subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1732
type: Mechanism
chembl id: CHEMBL_MEC_1732
has molecule: CHEMBL43708
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1538
type: Mechanism
chembl id: CHEMBL_MEC_1538
has molecule: CHEMBL983
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4559
type: Mechanism
chembl id: CHEMBL_MEC_4559
has molecule: CHEMBL75133
has target: CHEMBL2363070
mechanism description: Retinoid X receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_853
type: Mechanism
chembl id: CHEMBL_MEC_853
has molecule: CHEMBL1029
has target: CHEMBL2063
mechanism description: Ceramide glucosyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5744
type: Mechanism
chembl id: CHEMBL_MEC_5744
has molecule: CHEMBL73822
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1299
type: Mechanism
chembl id: CHEMBL_MEC_1299
has molecule: CHEMBL928
has target: CHEMBL2062
mechanism description: Ryanodine receptor 3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_248
type: Mechanism
chembl id: CHEMBL_MEC_248
has molecule: CHEMBL928
has target: CHEMBL1846
mechanism description: Ryanodine receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_220
type: Mechanism
chembl id: CHEMBL_MEC_220
has molecule: CHEMBL995
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_742
type: Mechanism
chembl id: CHEMBL_MEC_742
has molecule: CHEMBL1025
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1183
type: Mechanism
chembl id: CHEMBL_MEC_1183
has molecule: CHEMBL1021
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1049
type: Mechanism
chembl id: CHEMBL_MEC_1049
has molecule: CHEMBL924
has target: CHEMBL1782
mechanism description: Farnesyl diphosphate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_246
type: Mechanism
chembl id: CHEMBL_MEC_246
has molecule: CHEMBL1009
has target: CHEMBL234
mechanism description: Dopamine D3 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_831
type: Mechanism
chembl id: CHEMBL_MEC_831
has molecule: CHEMBL991
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5216
type: Mechanism
chembl id: CHEMBL_MEC_5216
has molecule: CHEMBL68055
has target: CHEMBL2093866
mechanism description: Estrogen receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_1460
type: Mechanism
chembl id: CHEMBL_MEC_1460
has molecule: CHEMBL1070
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1249
type: Mechanism
chembl id: CHEMBL_MEC_1249
has molecule: CHEMBL1073
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_642
type: Mechanism
chembl id: CHEMBL_MEC_642
has molecule: CHEMBL1051
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_147
type: Mechanism
chembl id: CHEMBL_MEC_147
has molecule: CHEMBL998
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1204
type: Mechanism
chembl id: CHEMBL_MEC_1204
has molecule: CHEMBL1071
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2244
type: Mechanism
chembl id: CHEMBL_MEC_2244
has molecule: CHEMBL87992
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_515
type: Mechanism
chembl id: CHEMBL_MEC_515
has molecule: CHEMBL1042
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5332
type: Mechanism
chembl id: CHEMBL_MEC_5332
has molecule: CHEMBL276711
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5331
type: Mechanism
chembl id: CHEMBL_MEC_5331
has molecule: CHEMBL276711
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5300
type: Mechanism
chembl id: CHEMBL_MEC_5300
has molecule: CHEMBL91829
has target: CHEMBL3045
mechanism description: Protein kinase C beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_336
type: Mechanism
chembl id: CHEMBL_MEC_336
has molecule: CHEMBL1046
has target: CHEMBL1873
mechanism description: Tissue-type plasminogen activator inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_86
type: Mechanism
chembl id: CHEMBL_MEC_86
has molecule: CHEMBL1046
has target: CHEMBL1801
mechanism description: Plasminogen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1041
type: Mechanism
chembl id: CHEMBL_MEC_1041
has molecule: CHEMBL1111
has target: CHEMBL2096678
mechanism description: Endothelin receptor, ET-A/ET-B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5321
type: Mechanism
chembl id: CHEMBL_MEC_5321
has molecule: CHEMBL101253
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5320
type: Mechanism
chembl id: CHEMBL_MEC_5320
has molecule: CHEMBL101253
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5322
type: Mechanism
chembl id: CHEMBL_MEC_5322
has molecule: CHEMBL101253
has target: CHEMBL1844
mechanism description: Macrophage colony stimulating factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5319
type: Mechanism
chembl id: CHEMBL_MEC_5319
has molecule: CHEMBL101253
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_649
type: Mechanism
chembl id: CHEMBL_MEC_649
has molecule: CHEMBL1116
has target: CHEMBL242
mechanism description: Estrogen receptor beta modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4588
type: Mechanism
chembl id: CHEMBL_MEC_4588
has molecule: CHEMBL93747
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5333
type: Mechanism
chembl id: CHEMBL_MEC_5333
has molecule: CHEMBL274654
has target: CHEMBL2095217
mechanism description: Fibroblast growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5334
type: Mechanism
chembl id: CHEMBL_MEC_5334
has molecule: CHEMBL274654
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5335
type: Mechanism
chembl id: CHEMBL_MEC_5335
has molecule: CHEMBL274654
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2097
type: Mechanism
chembl id: CHEMBL_MEC_2097
has molecule: CHEMBL1100
has target: CHEMBL2362995
mechanism description: Voltage-gated T-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4589
type: Mechanism
chembl id: CHEMBL_MEC_4589
has molecule: CHEMBL107367
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5733
type: Mechanism
chembl id: CHEMBL_MEC_5733
has molecule: CHEMBL109480
has target: CHEMBL2095165
mechanism description: Heat shock protein HSP90 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1182
type: Mechanism
chembl id: CHEMBL_MEC_1182
has molecule: CHEMBL1120
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1961
type: Mechanism
chembl id: CHEMBL_MEC_1961
has molecule: CHEMBL1095
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1527
type: Mechanism
chembl id: CHEMBL_MEC_1527
has molecule: CHEMBL1134
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_2218
type: Mechanism
chembl id: CHEMBL_MEC_2218
has molecule: CHEMBL1141
mechanism description: Unknown

CHEMBL_MEC_2165
type: Mechanism
chembl id: CHEMBL_MEC_2165
has molecule: CHEMBL108545
mechanism description: Unknown

CHEMBL_MEC_743
type: Mechanism
chembl id: CHEMBL_MEC_743
has molecule: CHEMBL1128
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4768
type: Mechanism
chembl id: CHEMBL_MEC_4768
has molecule: CHEMBL124660
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4769
type: Mechanism
chembl id: CHEMBL_MEC_4769
has molecule: CHEMBL124660
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4767
type: Mechanism
chembl id: CHEMBL_MEC_4767
has molecule: CHEMBL124660
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4163
type: Mechanism
chembl id: CHEMBL_MEC_4163
has molecule: CHEMBL103667
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5386
type: Mechanism
chembl id: CHEMBL_MEC_5386
has molecule: CHEMBL119709
has target: CHEMBL256
mechanism description: Adenosine A3 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1578
type: Mechanism
chembl id: CHEMBL_MEC_1578
has molecule: CHEMBL1131
has target: CHEMBL2363071
mechanism description: Retinoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2212
type: Mechanism
chembl id: CHEMBL_MEC_2212
has molecule: CHEMBL1079604
mechanism description: Unknown

CHEMBL_MEC_5535
type: Mechanism
chembl id: CHEMBL_MEC_5535
has molecule: CHEMBL113461
has target: CHEMBL2362996
mechanism description: Voltage-gated potassium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_5204
type: Mechanism
chembl id: CHEMBL_MEC_5204
has molecule: CHEMBL111659
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1481
type: Mechanism
chembl id: CHEMBL_MEC_1481
has molecule: CHEMBL117785
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1934
type: Mechanism
chembl id: CHEMBL_MEC_1934
has molecule: CHEMBL1220
has target: CHEMBL2366045
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1015
type: Mechanism
chembl id: CHEMBL_MEC_1015
has molecule: CHEMBL1162
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1706
type: Mechanism
chembl id: CHEMBL_MEC_1706
has molecule: CHEMBL1232
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2147
type: Mechanism
chembl id: CHEMBL_MEC_2147
has molecule: CHEMBL1177
mechanism description: Unknown

CHEMBL_MEC_1900
type: Mechanism
chembl id: CHEMBL_MEC_1900
has molecule: CHEMBL1208
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_78
type: Mechanism
chembl id: CHEMBL_MEC_78
has molecule: CHEMBL1166
has target: CHEMBL204
mechanism description: Thrombin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4120
type: Mechanism
chembl id: CHEMBL_MEC_4120
has molecule: CHEMBL129857
has target: CHEMBL1991
mechanism description: Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4121
type: Mechanism
chembl id: CHEMBL_MEC_4121
has molecule: CHEMBL129857
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1902
type: Mechanism
chembl id: CHEMBL_MEC_1902
has molecule: CHEMBL1202
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1275
type: Mechanism
chembl id: CHEMBL_MEC_1275
has molecule: CHEMBL1280
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1542
type: Mechanism
chembl id: CHEMBL_MEC_1542
has molecule: CHEMBL1308
has target: CHEMBL2363044
mechanism description: Alcohol dehydrogenase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5604
type: Mechanism
chembl id: CHEMBL_MEC_5604
has molecule: CHEMBL148674
has target: CHEMBL3474
mechanism description: Phospholipase A2 group IIA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2210
type: Mechanism
chembl id: CHEMBL_MEC_2210
has molecule: CHEMBL1239
mechanism description: Unknown

CHEMBL_MEC_4579
type: Mechanism
chembl id: CHEMBL_MEC_4579
has molecule: CHEMBL146032
has target: CHEMBL208
mechanism description: Progesterone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1221
type: Mechanism
chembl id: CHEMBL_MEC_1221
has molecule: CHEMBL1311
has target: CHEMBL2111348
has binding site: CHEMBL BS 2654
mechanism description: Soluble guanylate cyclase activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_3900
type: Mechanism
chembl id: CHEMBL_MEC_3900
has molecule: CHEMBL146506
has target: CHEMBL2363071
mechanism description: Retinoid receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_48
type: Mechanism
chembl id: CHEMBL_MEC_48
has molecule: CHEMBL1231
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1513
type: Mechanism
chembl id: CHEMBL_MEC_1513
has molecule: CHEMBL1231
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_677
type: Mechanism
chembl id: CHEMBL_MEC_677
has molecule: CHEMBL1265
has target: CHEMBL2363069
mechanism description: Retinoic acid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2156
type: Mechanism
chembl id: CHEMBL_MEC_2156
has molecule: CHEMBL1243
mechanism description: Unknown

CHEMBL_MEC_4183
type: Mechanism
chembl id: CHEMBL_MEC_4183
has molecule: CHEMBL150894
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2175
type: Mechanism
chembl id: CHEMBL_MEC_2175
has molecule: CHEMBL1314
mechanism description: Reducing agent

CHEMBL_MEC_1928
type: Mechanism
chembl id: CHEMBL_MEC_1928
has molecule: CHEMBL1292
has target: CHEMBL2366041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1307
type: Mechanism
chembl id: CHEMBL_MEC_1307
has molecule: CHEMBL1337
has target: CHEMBL1861
mechanism description: 4-hydroxyphenylpyruvate dioxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1151
type: Mechanism
chembl id: CHEMBL_MEC_1151
has molecule: CHEMBL1275
has target: CHEMBL2096905
mechanism description: Dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1458
type: Mechanism
chembl id: CHEMBL_MEC_1458
has molecule: CHEMBL1316
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_884
type: Mechanism
chembl id: CHEMBL_MEC_884
has molecule: CHEMBL1345
has target: CHEMBL222
mechanism description: Norepinephrine transporter substrate
mechanism action type: SUBSTRATE

CHEMBL_MEC_1000
type: Mechanism
chembl id: CHEMBL_MEC_1000
has molecule: CHEMBL1326
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1549
type: Mechanism
chembl id: CHEMBL_MEC_1549
has molecule: CHEMBL1341
has target: CHEMBL2363052
has binding site: CHEMBL BS 2639
mechanism description: Glycine receptor (alpha-1/beta) agonist
mechanism action type: AGONIST

CHEMBL_MEC_1587
type: Mechanism
chembl id: CHEMBL_MEC_1587
has molecule: CHEMBL1341
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_684
type: Mechanism
chembl id: CHEMBL_MEC_684
has molecule: CHEMBL1373
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2316
type: Mechanism
chembl id: CHEMBL_MEC_2316
has molecule: CHEMBL189963
has target: CHEMBL2111455
mechanism description: CDK6/cyclin D1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2317
type: Mechanism
chembl id: CHEMBL_MEC_2317
has molecule: CHEMBL189963
has target: CHEMBL1907601
mechanism description: CDK4/cyclin D1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5230
type: Mechanism
chembl id: CHEMBL_MEC_5230
has molecule: CHEMBL186179
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5229
type: Mechanism
chembl id: CHEMBL_MEC_5229
has molecule: CHEMBL186179
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_2220
type: Mechanism
chembl id: CHEMBL_MEC_2220
has molecule: CHEMBL1366
mechanism description: Unknown

CHEMBL_MEC_5164
type: Mechanism
chembl id: CHEMBL_MEC_5164
has molecule: CHEMBL182066
has target: CHEMBL1907603
mechanism description: Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1855
type: Mechanism
chembl id: CHEMBL_MEC_1855
has molecule: CHEMBL1351
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5047
type: Mechanism
chembl id: CHEMBL_MEC_5047
has molecule: CHEMBL189676
has target: CHEMBL218
mechanism description: Cannabinoid CB1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1321
type: Mechanism
chembl id: CHEMBL_MEC_1321
has molecule: CHEMBL1395
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1062
type: Mechanism
chembl id: CHEMBL_MEC_1062
has molecule: CHEMBL193240
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1375
type: Mechanism
chembl id: CHEMBL_MEC_1375
has molecule: CHEMBL198362
has target: CHEMBL244
mechanism description: Coagulation factor X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4365
type: Mechanism
chembl id: CHEMBL_MEC_4365
has molecule: CHEMBL190333
has target: CHEMBL3961
mechanism description: MAP kinase p38 beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4364
type: Mechanism
chembl id: CHEMBL_MEC_4364
has molecule: CHEMBL190333
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5658
type: Mechanism
chembl id: CHEMBL_MEC_5658
has molecule: CHEMBL190412
has target: CHEMBL1744525
mechanism description: Nicotinamide phosphoribosyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_812
type: Mechanism
chembl id: CHEMBL_MEC_812
has molecule: CHEMBL1370
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5126
type: Mechanism
chembl id: CHEMBL_MEC_5126
has molecule: CHEMBL188462
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_4453
type: Mechanism
chembl id: CHEMBL_MEC_4453
has molecule: CHEMBL197669
has target: CHEMBL251
mechanism description: Adenosine A2a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5017
type: Mechanism
chembl id: CHEMBL_MEC_5017
has molecule: CHEMBL189475
has target: CHEMBL2434
mechanism description: Interleukin-8 receptor B modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5016
type: Mechanism
chembl id: CHEMBL_MEC_5016
has molecule: CHEMBL189475
has target: CHEMBL4029
mechanism description: Interleukin-8 receptor A modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5113
type: Mechanism
chembl id: CHEMBL_MEC_5113
has molecule: CHEMBL207433
has target: CHEMBL4794
mechanism description: Vanilloid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_945
type: Mechanism
chembl id: CHEMBL_MEC_945
has molecule: CHEMBL204656
has target: CHEMBL3471
mechanism description: Human immunodeficiency virus type 1 integrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4739
type: Mechanism
chembl id: CHEMBL_MEC_4739
has molecule: CHEMBL206834
has target: CHEMBL3905
mechanism description: Tyrosine-protein kinase Lyn inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4738
type: Mechanism
chembl id: CHEMBL_MEC_4738
has molecule: CHEMBL206834
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4888
type: Mechanism
chembl id: CHEMBL_MEC_4888
has molecule: CHEMBL208427
has target: CHEMBL246
mechanism description: Beta-3 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4359
type: Mechanism
chembl id: CHEMBL_MEC_4359
has molecule: CHEMBL203567
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_871
type: Mechanism
chembl id: CHEMBL_MEC_871
has molecule: CHEMBL1404
has target: CHEMBL2072
mechanism description: Sodium channel protein type IV alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_529
type: Mechanism
chembl id: CHEMBL_MEC_529
has molecule: CHEMBL1404
has target: CHEMBL1980
mechanism description: Sodium channel protein type V alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2312
type: Mechanism
chembl id: CHEMBL_MEC_2312
has molecule: CHEMBL206253
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4992
type: Mechanism
chembl id: CHEMBL_MEC_4992
has molecule: CHEMBL207197
has target: CHEMBL3798
mechanism description: Calcitonin gene-related peptide type 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_383
type: Mechanism
chembl id: CHEMBL_MEC_383
has molecule: CHEMBL413
has target: CHEMBL1902
mechanism description: FK506-binding protein 1A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1668
type: Mechanism
chembl id: CHEMBL_MEC_1668
has molecule: CHEMBL1439
has target: CHEMBL2364670
mechanism description: Bacterial beta-lactamase TEM inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1615
type: Mechanism
chembl id: CHEMBL_MEC_1615
has molecule: CHEMBL856
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1960
type: Mechanism
chembl id: CHEMBL_MEC_1960
has molecule: CHEMBL856
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1472
type: Mechanism
chembl id: CHEMBL_MEC_1472
has molecule: CHEMBL184
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4586
type: Mechanism
chembl id: CHEMBL_MEC_4586
has molecule: CHEMBL219586
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_827
type: Mechanism
chembl id: CHEMBL_MEC_827
has molecule: CHEMBL223228
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1995
type: Mechanism
chembl id: CHEMBL_MEC_1995
has molecule: CHEMBL750
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1895
type: Mechanism
chembl id: CHEMBL_MEC_1895
has molecule: CHEMBL185
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_486
type: Mechanism
chembl id: CHEMBL_MEC_486
has molecule: CHEMBL185
has target: CHEMBL1952
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1888
type: Mechanism
chembl id: CHEMBL_MEC_1888
has molecule: CHEMBL185
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_87
type: Mechanism
chembl id: CHEMBL_MEC_87
has molecule: CHEMBL220491
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_474
type: Mechanism
chembl id: CHEMBL_MEC_474
has molecule: CHEMBL160
has target: CHEMBL1949
mechanism description: Cyclophilin A modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5168
type: Mechanism
chembl id: CHEMBL_MEC_5168
has molecule: CHEMBL222460
has target: CHEMBL4304
mechanism description: Calcium-activated potassium channel subunit alpha-1 activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_1280
type: Mechanism
chembl id: CHEMBL_MEC_1280
has molecule: CHEMBL1428
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_662
type: Mechanism
chembl id: CHEMBL_MEC_662
has molecule: CHEMBL1428
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_737
type: Mechanism
chembl id: CHEMBL_MEC_737
has molecule: CHEMBL211471
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1285
type: Mechanism
chembl id: CHEMBL_MEC_1285
has molecule: CHEMBL215645
has target: CHEMBL2095233
mechanism description: Cholinesterases; ACHE & BCHE inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1153
type: Mechanism
chembl id: CHEMBL_MEC_1153
has molecule: CHEMBL1423
has target: CHEMBL2096905
mechanism description: Dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_600
type: Mechanism
chembl id: CHEMBL_MEC_600
has molecule: CHEMBL1423
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2200
type: Mechanism
chembl id: CHEMBL_MEC_2200
has molecule: CHEMBL1413
has target: CHEMBL2363058
mechanism description: Iron chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_2224
type: Mechanism
chembl id: CHEMBL_MEC_2224
has molecule: CHEMBL1413
has target: CHEMBL2366381
mechanism description: Aluminium chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_19
type: Mechanism
chembl id: CHEMBL_MEC_19
has molecule: CHEMBL1450
has target: CHEMBL1777
mechanism description: Cytochrome b inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_442
type: Mechanism
chembl id: CHEMBL_MEC_442
has molecule: CHEMBL1466
has target: CHEMBL1930
mechanism description: Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1284
type: Mechanism
chembl id: CHEMBL_MEC_1284
has molecule: CHEMBL231813
has target: CHEMBL2095231
mechanism description: Hepatitis C virus serine protease, NS3/NS4A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4500
type: Mechanism
chembl id: CHEMBL_MEC_4500
has molecule: CHEMBL229430
has target: CHEMBL4794
mechanism description: Vanilloid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1405
type: Mechanism
chembl id: CHEMBL_MEC_1405
has molecule: CHEMBL1463
has target: CHEMBL2364680
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_975
type: Mechanism
chembl id: CHEMBL_MEC_975
has molecule: CHEMBL1463
has target: CHEMBL4665
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1063
type: Mechanism
chembl id: CHEMBL_MEC_1063
has molecule: CHEMBL190
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1136
type: Mechanism
chembl id: CHEMBL_MEC_1136
has molecule: CHEMBL190
has target: CHEMBL2094125
mechanism description: Phosphodiesterase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1216
type: Mechanism
chembl id: CHEMBL_MEC_1216
has molecule: CHEMBL190
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1330
type: Mechanism
chembl id: CHEMBL_MEC_1330
has molecule: CHEMBL1445
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1762
type: Mechanism
chembl id: CHEMBL_MEC_1762
has molecule: CHEMBL1446
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4827
type: Mechanism
chembl id: CHEMBL_MEC_4827
has molecule: CHEMBL230011
has target: CHEMBL3267
mechanism description: PI3-kinase p110-gamma subunit inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4828
type: Mechanism
chembl id: CHEMBL_MEC_4828
has molecule: CHEMBL230011
has target: CHEMBL3130
mechanism description: PI3-kinase p110-delta subunit inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2435
type: Mechanism
chembl id: CHEMBL_MEC_2435
has molecule: CHEMBL238804
has target: CHEMBL1995
mechanism description: Prostanoid IP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1371
type: Mechanism
chembl id: CHEMBL_MEC_1371
has molecule: CHEMBL1471
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_843
type: Mechanism
chembl id: CHEMBL_MEC_843
has molecule: CHEMBL240597
has target: CHEMBL2047
mechanism description: Bile acid receptor FXR agonist
mechanism action type: AGONIST

CHEMBL_MEC_1857
type: Mechanism
chembl id: CHEMBL_MEC_1857
has molecule: CHEMBL1455
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_467
type: Mechanism
chembl id: CHEMBL_MEC_467
has molecule: CHEMBL237500
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4990
type: Mechanism
chembl id: CHEMBL_MEC_4990
has molecule: CHEMBL244243
has target: CHEMBL1889
mechanism description: Vasopressin V1a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5060
type: Mechanism
chembl id: CHEMBL_MEC_5060
has molecule: CHEMBL257978
has target: CHEMBL229
mechanism description: Alpha-1a adrenergic receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_4382
type: Mechanism
chembl id: CHEMBL_MEC_4382
has molecule: CHEMBL258805
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1011
type: Mechanism
chembl id: CHEMBL_MEC_1011
has molecule: CHEMBL1531
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4777
type: Mechanism
chembl id: CHEMBL_MEC_4777
has molecule: CHEMBL253969
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1080
type: Mechanism
chembl id: CHEMBL_MEC_1080
has molecule: CHEMBL1503
has target: CHEMBL2095173
has binding site: CHEMBL BS 2651
mechanism description: Potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1584
type: Mechanism
chembl id: CHEMBL_MEC_1584
has molecule: CHEMBL254219
has target: CHEMBL2095186
has binding site: CHEMBL BS 2653
mechanism description: Sodium/potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_652
type: Mechanism
chembl id: CHEMBL_MEC_652
has molecule: CHEMBL1489
has target: CHEMBL1992
mechanism description: DNA (cytosine-5)-methyltransferase 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_654
type: Mechanism
chembl id: CHEMBL_MEC_654
has molecule: CHEMBL1489
has target: CHEMBL1993
mechanism description: DNA (cytosine-5)-methyltransferase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1894
type: Mechanism
chembl id: CHEMBL_MEC_1894
has molecule: CHEMBL1489
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1873
type: Mechanism
chembl id: CHEMBL_MEC_1873
has molecule: CHEMBL1489
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4760
type: Mechanism
chembl id: CHEMBL_MEC_4760
has molecule: CHEMBL254760
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4763
type: Mechanism
chembl id: CHEMBL_MEC_4763
has molecule: CHEMBL254760
has target: CHEMBL4128
mechanism description: Tyrosine-protein kinase TIE-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4762
type: Mechanism
chembl id: CHEMBL_MEC_4762
has molecule: CHEMBL254760
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4761
type: Mechanism
chembl id: CHEMBL_MEC_4761
has molecule: CHEMBL254760
has target: CHEMBL2689
mechanism description: Macrophage-stimulating protein receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_663
type: Mechanism
chembl id: CHEMBL_MEC_663
has molecule: CHEMBL1480
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1282
type: Mechanism
chembl id: CHEMBL_MEC_1282
has molecule: CHEMBL1480
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_869
type: Mechanism
chembl id: CHEMBL_MEC_869
has molecule: CHEMBL1098
has target: CHEMBL2072
mechanism description: Sodium channel protein type IV alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_5719
type: Mechanism
chembl id: CHEMBL_MEC_5719
has molecule: CHEMBL257704
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1738
type: Mechanism
chembl id: CHEMBL_MEC_1738
has molecule: CHEMBL1525
has target: CHEMBL2362985
mechanism description: Voltage-sensitive sodium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_5156
type: Mechanism
chembl id: CHEMBL_MEC_5156
has molecule: CHEMBL238465
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1600
type: Mechanism
chembl id: CHEMBL_MEC_1600
has molecule: CHEMBL452
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1804
type: Mechanism
chembl id: CHEMBL_MEC_1804
has molecule: CHEMBL267345
has target: CHEMBL2364028
mechanism description: Ergosterol sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_1022
type: Mechanism
chembl id: CHEMBL_MEC_1022
has molecule: CHEMBL1533
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5264
type: Mechanism
chembl id: CHEMBL_MEC_5264
has molecule: CHEMBL270995
has target: CHEMBL2095217
mechanism description: Fibroblast growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5265
type: Mechanism
chembl id: CHEMBL_MEC_5265
has molecule: CHEMBL270995
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_638
type: Mechanism
chembl id: CHEMBL_MEC_638
has molecule: CHEMBL266481
has target: CHEMBL1985
mechanism description: Glucagon receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5427
type: Mechanism
chembl id: CHEMBL_MEC_5427
has molecule: CHEMBL266510
has target: CHEMBL2925
mechanism description: Voltage-gated potassium channel subunit Kv7.5 activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_5428
type: Mechanism
chembl id: CHEMBL_MEC_5428
has molecule: CHEMBL266510
has target: CHEMBL3576
mechanism description: Voltage-gated potassium channel subunit Kv7.4 activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_5430
type: Mechanism
chembl id: CHEMBL_MEC_5430
has molecule: CHEMBL266510
has target: CHEMBL2221348
mechanism description: Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_5426
type: Mechanism
chembl id: CHEMBL_MEC_5426
has molecule: CHEMBL266510
has target: CHEMBL4304
mechanism description: Calcium-activated potassium channel subunit alpha-1 opener
mechanism action type: OPENER

CHEMBL_MEC_5429
type: Mechanism
chembl id: CHEMBL_MEC_5429
has molecule: CHEMBL266510
has target: CHEMBL2476
mechanism description: Voltage-gated potassium channel subunit Kv7.2 activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_5431
type: Mechanism
chembl id: CHEMBL_MEC_5431
has molecule: CHEMBL266510
has target: CHEMBL3707192
mechanism description: Voltage-gated potassium channel KCNQ3/KCNQ4 activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_89
type: Mechanism
chembl id: CHEMBL_MEC_89
has molecule: CHEMBL17
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_16
type: Mechanism
chembl id: CHEMBL_MEC_16
has molecule: CHEMBL17
has target: CHEMBL261
mechanism description: Carbonic anhydrase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_956
type: Mechanism
chembl id: CHEMBL_MEC_956
has molecule: CHEMBL17
has target: CHEMBL3729
mechanism description: Carbonic anhydrase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_927
type: Mechanism
chembl id: CHEMBL_MEC_927
has molecule: CHEMBL17
has target: CHEMBL3242
mechanism description: Carbonic anhydrase XII inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5223
type: Mechanism
chembl id: CHEMBL_MEC_5223
has molecule: CHEMBL267431
has target: CHEMBL208
mechanism description: Progesterone receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_1559
type: Mechanism
chembl id: CHEMBL_MEC_1559
has molecule: CHEMBL1430
has target: CHEMBL2363057
mechanism description: Copper chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_680
type: Mechanism
chembl id: CHEMBL_MEC_680
has molecule: CHEMBL1539
has target: CHEMBL2013
mechanism description: Dihydropteroate synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1618
type: Mechanism
chembl id: CHEMBL_MEC_1618
has molecule: CHEMBL448
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_716
type: Mechanism
chembl id: CHEMBL_MEC_716
has molecule: CHEMBL270190
has target: CHEMBL233
mechanism description: Mu opioid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_249
type: Mechanism
chembl id: CHEMBL_MEC_249
has molecule: CHEMBL64
has target: CHEMBL1849
mechanism description: Enoyl-[acyl-carrier-protein] reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1247
type: Mechanism
chembl id: CHEMBL_MEC_1247
has molecule: CHEMBL498
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4072
type: Mechanism
chembl id: CHEMBL_MEC_4072
has molecule: CHEMBL271220
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_947
type: Mechanism
chembl id: CHEMBL_MEC_947
has molecule: CHEMBL271227
has target: CHEMBL3522
mechanism description: Cytochrome P450 17A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1390
type: Mechanism
chembl id: CHEMBL_MEC_1390
has molecule: CHEMBL264241
has target: CHEMBL2364673
mechanism description: 1,3-beta-glucan synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_350
type: Mechanism
chembl id: CHEMBL_MEC_350
has molecule: CHEMBL435
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_767
type: Mechanism
chembl id: CHEMBL_MEC_767
has molecule: CHEMBL1549
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5807
type: Mechanism
chembl id: CHEMBL_MEC_5807
has molecule: CHEMBL260046
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4464
type: Mechanism
chembl id: CHEMBL_MEC_4464
has molecule: CHEMBL260933
has target: CHEMBL255
mechanism description: Adenosine A2b receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5508
type: Mechanism
chembl id: CHEMBL_MEC_5508
has molecule: CHEMBL262075
has target: CHEMBL1962
mechanism description: GABA receptor alpha-1 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1862
type: Mechanism
chembl id: CHEMBL_MEC_1862
has molecule: CHEMBL416
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1782
type: Mechanism
chembl id: CHEMBL_MEC_1782
has molecule: CHEMBL1506
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_231
type: Mechanism
chembl id: CHEMBL_MEC_231
has molecule: CHEMBL1515
has target: CHEMBL1839
mechanism description: Thyroid peroxidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1852
type: Mechanism
chembl id: CHEMBL_MEC_1852
has molecule: CHEMBL514
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_221
type: Mechanism
chembl id: CHEMBL_MEC_221
has molecule: CHEMBL1513
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1536
type: Mechanism
chembl id: CHEMBL_MEC_1536
has molecule: CHEMBL984
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1444
type: Mechanism
chembl id: CHEMBL_MEC_1444
has molecule: CHEMBL638
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1882
type: Mechanism
chembl id: CHEMBL_MEC_1882
has molecule: CHEMBL513
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1892
type: Mechanism
chembl id: CHEMBL_MEC_1892
has molecule: CHEMBL513
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_933
type: Mechanism
chembl id: CHEMBL_MEC_933
has molecule: CHEMBL513
has target: CHEMBL2755
mechanism description: Glutathione reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5062
type: Mechanism
chembl id: CHEMBL_MEC_5062
has molecule: CHEMBL279260
has target: CHEMBL246
mechanism description: Beta-3 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_891
type: Mechanism
chembl id: CHEMBL_MEC_891
has molecule: CHEMBL612
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1486
type: Mechanism
chembl id: CHEMBL_MEC_1486
has molecule: CHEMBL612
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_693
type: Mechanism
chembl id: CHEMBL_MEC_693
has molecule: CHEMBL612
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_5231
type: Mechanism
chembl id: CHEMBL_MEC_5231
has molecule: CHEMBL282686
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_5232
type: Mechanism
chembl id: CHEMBL_MEC_5232
has molecule: CHEMBL282686
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_691
type: Mechanism
chembl id: CHEMBL_MEC_691
has molecule: CHEMBL904
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_890
type: Mechanism
chembl id: CHEMBL_MEC_890
has molecule: CHEMBL904
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1999
type: Mechanism
chembl id: CHEMBL_MEC_1999
has molecule: CHEMBL679
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_516
type: Mechanism
chembl id: CHEMBL_MEC_516
has molecule: CHEMBL1536
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1457
type: Mechanism
chembl id: CHEMBL_MEC_1457
has molecule: CHEMBL122
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1214
type: Mechanism
chembl id: CHEMBL_MEC_1214
has molecule: CHEMBL113
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1255
type: Mechanism
chembl id: CHEMBL_MEC_1255
has molecule: CHEMBL585
has target: CHEMBL2107836
has binding site: CHEMBL BS 2634
mechanism description: Amiloride-sensitive sodium channel, ENaC blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1573
type: Mechanism
chembl id: CHEMBL_MEC_1573
has molecule: CHEMBL548
has target: CHEMBL2363068
mechanism description: Prostaglandin E2 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1439
type: Mechanism
chembl id: CHEMBL_MEC_1439
has molecule: CHEMBL625
has target: CHEMBL2364705
has binding site: CHEMBL BS 2632
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1435
type: Mechanism
chembl id: CHEMBL_MEC_1435
has molecule: CHEMBL625
has target: CHEMBL2364704
has binding site: CHEMBL BS 2631
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5849
type: Mechanism
chembl id: CHEMBL_MEC_5849
has molecule: CHEMBL272980
has target: CHEMBL3192
mechanism description: Histone deacetylase 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5846
type: Mechanism
chembl id: CHEMBL_MEC_5846
has molecule: CHEMBL272980
has target: CHEMBL1937
mechanism description: Histone deacetylase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5651
type: Mechanism
chembl id: CHEMBL_MEC_5651
has molecule: CHEMBL272980
has target: CHEMBL325
mechanism description: Histone deacetylase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5847
type: Mechanism
chembl id: CHEMBL_MEC_5847
has molecule: CHEMBL272980
has target: CHEMBL1829
mechanism description: Histone deacetylase 3
mechanism action type: INHIBITOR

CHEMBL_MEC_5848
type: Mechanism
chembl id: CHEMBL_MEC_5848
has molecule: CHEMBL272980
has target: CHEMBL3310
mechanism description: Histone deacetylase 11
mechanism action type: INHIBITOR

CHEMBL_MEC_1462
type: Mechanism
chembl id: CHEMBL_MEC_1462
has molecule: CHEMBL118
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1433
type: Mechanism
chembl id: CHEMBL_MEC_1433
has molecule: CHEMBL562
has target: CHEMBL2364703
has binding site: CHEMBL BS 2630
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1733
type: Mechanism
chembl id: CHEMBL_MEC_1733
has molecule: CHEMBL530
has target: CHEMBL2354313
mechanism description: Bacterial penicillin-binding protein 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1360
type: Mechanism
chembl id: CHEMBL_MEC_1360
has molecule: CHEMBL500
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_316
type: Mechanism
chembl id: CHEMBL_MEC_316
has molecule: CHEMBL500
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_1923
type: Mechanism
chembl id: CHEMBL_MEC_1923
has molecule: CHEMBL713
has target: CHEMBL2362994
mechanism description: DNA polymerase/reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_712
type: Mechanism
chembl id: CHEMBL_MEC_712
has molecule: CHEMBL688
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_842
type: Mechanism
chembl id: CHEMBL_MEC_842
has molecule: CHEMBL1551
has target: CHEMBL2047
mechanism description: Bile acid receptor FXR agonist
mechanism action type: AGONIST

CHEMBL_MEC_348
type: Mechanism
chembl id: CHEMBL_MEC_348
has molecule: CHEMBL1532
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1788
type: Mechanism
chembl id: CHEMBL_MEC_1788
has molecule: CHEMBL529
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1303
type: Mechanism
chembl id: CHEMBL_MEC_1303
has molecule: CHEMBL1544
has target: CHEMBL2111462
mechanism description: Thyroid hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1832
type: Mechanism
chembl id: CHEMBL_MEC_1832
has molecule: CHEMBL572
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1338
type: Mechanism
chembl id: CHEMBL_MEC_1338
has molecule: CHEMBL714
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_320
type: Mechanism
chembl id: CHEMBL_MEC_320
has molecule: CHEMBL649
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1354
type: Mechanism
chembl id: CHEMBL_MEC_1354
has molecule: CHEMBL649
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1989
type: Mechanism
chembl id: CHEMBL_MEC_1989
has molecule: CHEMBL919
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1380
type: Mechanism
chembl id: CHEMBL_MEC_1380
has molecule: CHEMBL799
has target: CHEMBL241
mechanism description: Phosphodiesterase 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2098
type: Mechanism
chembl id: CHEMBL_MEC_2098
has molecule: CHEMBL697
has target: CHEMBL2362995
mechanism description: Voltage-gated T-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1445
type: Mechanism
chembl id: CHEMBL_MEC_1445
has molecule: CHEMBL295698
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1595
type: Mechanism
chembl id: CHEMBL_MEC_1595
has molecule: CHEMBL979
has target: CHEMBL2093872
has binding site: CHEMBL BS 2616
mechanism description: GABA-A receptor; anion channel agonist
mechanism action type: AGONIST

CHEMBL_MEC_1040
type: Mechanism
chembl id: CHEMBL_MEC_1040
has molecule: CHEMBL957
has target: CHEMBL2096678
mechanism description: Endothelin receptor, ET-A/ET-B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1558
type: Mechanism
chembl id: CHEMBL_MEC_1558
has molecule: CHEMBL497
has target: CHEMBL2363056
mechanism description: Zinc chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1564
type: Mechanism
chembl id: CHEMBL_MEC_1564
has molecule: CHEMBL497
has target: CHEMBL2363058
mechanism description: Iron chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1561
type: Mechanism
chembl id: CHEMBL_MEC_1561
has molecule: CHEMBL497
has target: CHEMBL2363057
mechanism description: Copper chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_5577
type: Mechanism
chembl id: CHEMBL_MEC_5577
has molecule: CHEMBL289228
has target: CHEMBL2094108
mechanism description: Protein farnesyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1619
type: Mechanism
chembl id: CHEMBL_MEC_1619
has molecule: CHEMBL971
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1173
type: Mechanism
chembl id: CHEMBL_MEC_1173
has molecule: CHEMBL154
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2173
type: Mechanism
chembl id: CHEMBL_MEC_2173
has molecule: CHEMBL942
mechanism description: Unknown

CHEMBL_MEC_1396
type: Mechanism
chembl id: CHEMBL_MEC_1396
has molecule: CHEMBL937
has target: CHEMBL2364676
mechanism description: Nematode GABA-A receptor positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1495
type: Mechanism
chembl id: CHEMBL_MEC_1495
has molecule: CHEMBL114
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_185
type: Mechanism
chembl id: CHEMBL_MEC_185
has molecule: CHEMBL779
has target: CHEMBL1827
mechanism description: Phosphodiesterase 5A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5270
type: Mechanism
chembl id: CHEMBL_MEC_5270
has molecule: CHEMBL290352
has target: CHEMBL1908389
mechanism description: Mitogen-activated protein kinase kinase kinase 12 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5266
type: Mechanism
chembl id: CHEMBL_MEC_5266
has molecule: CHEMBL290352
has target: CHEMBL2708
mechanism description: Mitogen-activated protein kinase kinase kinase 11 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5267
type: Mechanism
chembl id: CHEMBL_MEC_5267
has molecule: CHEMBL290352
has target: CHEMBL2873
mechanism description: Mitogen-activated protein kinase kinase kinase 10 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5268
type: Mechanism
chembl id: CHEMBL_MEC_5268
has molecule: CHEMBL290352
has target: CHEMBL2872
mechanism description: Mitogen-activated protein kinase kinase kinase 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5269
type: Mechanism
chembl id: CHEMBL_MEC_5269
has molecule: CHEMBL290352
has target: CHEMBL1163124
mechanism description: Mitogen-activated protein kinase kinase kinase 13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_85
type: Mechanism
chembl id: CHEMBL_MEC_85
has molecule: CHEMBL877
has target: CHEMBL1801
mechanism description: Plasminogen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1037
type: Mechanism
chembl id: CHEMBL_MEC_1037
has molecule: CHEMBL897
has target: CHEMBL1641348
mechanism description: Solute carrier family 22 member 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1042
type: Mechanism
chembl id: CHEMBL_MEC_1042
has molecule: CHEMBL897
has target: CHEMBL2073677
mechanism description: Solute carrier family 22 member 11 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1036
type: Mechanism
chembl id: CHEMBL_MEC_1036
has molecule: CHEMBL897
has target: CHEMBL1641347
mechanism description: Solute carrier family 22 member 6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5613
type: Mechanism
chembl id: CHEMBL_MEC_5613
has molecule: CHEMBL286738
has target: CHEMBL3559
mechanism description: Steryl-sulfatase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1929
type: Mechanism
chembl id: CHEMBL_MEC_1929
has molecule: CHEMBL788
has target: CHEMBL2366042
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_445
type: Mechanism
chembl id: CHEMBL_MEC_445
has molecule: CHEMBL964
has target: CHEMBL1935
mechanism description: Aldehyde dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1828
type: Mechanism
chembl id: CHEMBL_MEC_1828
has molecule: CHEMBL869
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_823
type: Mechanism
chembl id: CHEMBL_MEC_823
has molecule: CHEMBL929
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_986
type: Mechanism
chembl id: CHEMBL_MEC_986
has molecule: CHEMBL294199
has target: CHEMBL4794
mechanism description: Vanilloid receptor opener
mechanism action type: OPENER

CHEMBL_MEC_1700
type: Mechanism
chembl id: CHEMBL_MEC_1700
has molecule: CHEMBL927
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2387
type: Mechanism
chembl id: CHEMBL_MEC_2387
has molecule: CHEMBL1200467
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1059
type: Mechanism
chembl id: CHEMBL_MEC_1059
has molecule: CHEMBL1064
has target: CHEMBL402
mechanism description: HMG-CoA reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_833
type: Mechanism
chembl id: CHEMBL_MEC_833
has molecule: CHEMBL308954
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_337
type: Mechanism
chembl id: CHEMBL_MEC_337
has molecule: CHEMBL1072
has target: CHEMBL1874
mechanism description: Sodium-(potassium)-chloride cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2359
type: Mechanism
chembl id: CHEMBL_MEC_2359
has molecule: CHEMBL296419
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_346
type: Mechanism
chembl id: CHEMBL_MEC_346
has molecule: CHEMBL842
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1667
type: Mechanism
chembl id: CHEMBL_MEC_1667
has molecule: CHEMBL1003
has target: CHEMBL2364670
mechanism description: Bacterial beta-lactamase TEM inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1920
type: Mechanism
chembl id: CHEMBL_MEC_1920
has molecule: CHEMBL1059
has target: CHEMBL2363032
has binding site: CHEMBL BS 2657
mechanism description: Voltage-gated calcium channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5629
type: Mechanism
chembl id: CHEMBL_MEC_5629
has molecule: CHEMBL298734
has target: CHEMBL2094108
mechanism description: Protein farnesyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5588
type: Mechanism
chembl id: CHEMBL_MEC_5588
has molecule: CHEMBL313006
has target: CHEMBL3572
mechanism description: Cholesteryl ester transfer protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5642
type: Mechanism
chembl id: CHEMBL_MEC_5642
has molecule: CHEMBL325424
has target: CHEMBL3475
mechanism description: Plasminogen activator inhibitor-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_802
type: Mechanism
chembl id: CHEMBL_MEC_802
has molecule: CHEMBL1161
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_801
type: Mechanism
chembl id: CHEMBL_MEC_801
has molecule: CHEMBL1091
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5874
type: Mechanism
chembl id: CHEMBL_MEC_5874
has molecule: CHEMBL1169
has target: CHEMBL6065
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1514
type: Mechanism
chembl id: CHEMBL_MEC_1514
has molecule: CHEMBL1133
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_49
type: Mechanism
chembl id: CHEMBL_MEC_49
has molecule: CHEMBL1133
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5014
type: Mechanism
chembl id: CHEMBL_MEC_5014
has molecule: CHEMBL324547
has target: CHEMBL298
mechanism description: Cholecystokinin B receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1930
type: Mechanism
chembl id: CHEMBL_MEC_1930
has molecule: CHEMBL1129
has target: CHEMBL2366042
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_585
type: Mechanism
chembl id: CHEMBL_MEC_585
has molecule: CHEMBL1112
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_205
type: Mechanism
chembl id: CHEMBL_MEC_205
has molecule: CHEMBL1112
has target: CHEMBL217
mechanism description: Dopamine D2 receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_472
type: Mechanism
chembl id: CHEMBL_MEC_472
has molecule: CHEMBL1112
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_1605
type: Mechanism
chembl id: CHEMBL_MEC_1605
has molecule: CHEMBL1102
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1576
type: Mechanism
chembl id: CHEMBL_MEC_1576
has molecule: CHEMBL1023
has target: CHEMBL2363070
mechanism description: Retinoid X receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1431
type: Mechanism
chembl id: CHEMBL_MEC_1431
has molecule: CHEMBL325041
has target: CHEMBL2364701
has binding site: CHEMBL BS 2633
mechanism description: 26S proteosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1829
type: Mechanism
chembl id: CHEMBL_MEC_1829
has molecule: CHEMBL1103
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_608
type: Mechanism
chembl id: CHEMBL_MEC_608
has molecule: CHEMBL1201
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_212
type: Mechanism
chembl id: CHEMBL_MEC_212
has molecule: CHEMBL1201
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_811
type: Mechanism
chembl id: CHEMBL_MEC_811
has molecule: CHEMBL1152
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2188
type: Mechanism
chembl id: CHEMBL_MEC_2188
has molecule: CHEMBL1233
mechanism description: Unknown

CHEMBL_MEC_64
type: Mechanism
chembl id: CHEMBL_MEC_64
has molecule: CHEMBL344159
has target: CHEMBL1790
mechanism description: Vasopressin V2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1137
type: Mechanism
chembl id: CHEMBL_MEC_1137
has molecule: CHEMBL1218
has target: CHEMBL2094268
mechanism description: Melatonin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5053
type: Mechanism
chembl id: CHEMBL_MEC_5053
has molecule: CHEMBL345237
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5580
type: Mechanism
chembl id: CHEMBL_MEC_5580
has molecule: CHEMBL348475
has target: CHEMBL4302
mechanism description: P-glycoprotein 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4752
type: Mechanism
chembl id: CHEMBL_MEC_4752
has molecule: CHEMBL362558
has target: CHEMBL262
mechanism description: Glycogen synthase kinase-3 beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4753
type: Mechanism
chembl id: CHEMBL_MEC_4753
has molecule: CHEMBL362558
has target: CHEMBL2850
mechanism description: Glycogen synthase kinase-3 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1563
type: Mechanism
chembl id: CHEMBL_MEC_1563
has molecule: CHEMBL1234
has target: CHEMBL2363058
mechanism description: Iron chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_2025
type: Mechanism
chembl id: CHEMBL_MEC_2025
has molecule: CHEMBL1303
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1010
type: Mechanism
chembl id: CHEMBL_MEC_1010
has molecule: CHEMBL1387
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4435
type: Mechanism
chembl id: CHEMBL_MEC_4435
has molecule: CHEMBL375611
has target: CHEMBL5137
mechanism description: Metabotropic glutamate receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_4436
type: Mechanism
chembl id: CHEMBL_MEC_4436
has molecule: CHEMBL375611
has target: CHEMBL2888
mechanism description: Metabotropic glutamate receptor 3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1318
type: Mechanism
chembl id: CHEMBL_MEC_1318
has molecule: CHEMBL1274
has target: CHEMBL1871
mechanism description: Androgen Receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1925
type: Mechanism
chembl id: CHEMBL_MEC_1925
has molecule: CHEMBL374731
has target: CHEMBL2362994
mechanism description: DNA polymerase/reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_508
type: Mechanism
chembl id: CHEMBL_MEC_508
has molecule: CHEMBL1388
has target: CHEMBL1973
mechanism description: Tyrosinase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5653
type: Mechanism
chembl id: CHEMBL_MEC_5653
has molecule: CHEMBL377559
has target: CHEMBL2095165
mechanism description: Heat shock protein HSP90 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_258
type: Mechanism
chembl id: CHEMBL_MEC_258
has molecule: CHEMBL1252
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1453
type: Mechanism
chembl id: CHEMBL_MEC_1453
has molecule: CHEMBL1397
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2034
type: Mechanism
chembl id: CHEMBL_MEC_2034
has molecule: CHEMBL1401
has target: CHEMBL2364027
mechanism description: Pyruvate:ferredoxin oxidoreductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2033
type: Mechanism
chembl id: CHEMBL_MEC_2033
has molecule: CHEMBL1401
has target: CHEMBL2364026
mechanism description: Pyruvate:ferredoxin oxidoreductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1771
type: Mechanism
chembl id: CHEMBL_MEC_1771
has molecule: CHEMBL1440
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_813
type: Mechanism
chembl id: CHEMBL_MEC_813
has molecule: CHEMBL384467
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4501
type: Mechanism
chembl id: CHEMBL_MEC_4501
has molecule: CHEMBL398338
has target: CHEMBL4794
mechanism description: Vanilloid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1503
type: Mechanism
chembl id: CHEMBL_MEC_1503
has molecule: CHEMBL398435
has target: CHEMBL2001
mechanism description: Purinergic receptor P2Y12 negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_985
type: Mechanism
chembl id: CHEMBL_MEC_985
has molecule: CHEMBL181
has target: CHEMBL4770
mechanism description: Potassium channel, inwardly rectifying, subfamily J, member 8 opener
mechanism action type: OPENER

CHEMBL_MEC_360
type: Mechanism
chembl id: CHEMBL_MEC_360
has molecule: CHEMBL181
has target: CHEMBL1886
mechanism description: Potassium channel, inwardly rectifying, subfamily J, member 11 opener
mechanism action type: OPENER

CHEMBL_MEC_857
type: Mechanism
chembl id: CHEMBL_MEC_857
has molecule: CHEMBL1405
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1811
type: Mechanism
chembl id: CHEMBL_MEC_1811
has molecule: CHEMBL387675
has target: CHEMBL2364031
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_416
type: Mechanism
chembl id: CHEMBL_MEC_416
has molecule: CHEMBL1421
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_301
type: Mechanism
chembl id: CHEMBL_MEC_301
has molecule: CHEMBL1421
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_446
type: Mechanism
chembl id: CHEMBL_MEC_446
has molecule: CHEMBL1421
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_854
type: Mechanism
chembl id: CHEMBL_MEC_854
has molecule: CHEMBL1421
has target: CHEMBL2068
mechanism description: Ephrin type-A receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1634
type: Mechanism
chembl id: CHEMBL_MEC_1634
has molecule: CHEMBL1421
has target: CHEMBL2363074
mechanism description: SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5581
type: Mechanism
chembl id: CHEMBL_MEC_5581
has molecule: CHEMBL395091
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_776
type: Mechanism
chembl id: CHEMBL_MEC_776
has molecule: CHEMBL1512
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5342
type: Mechanism
chembl id: CHEMBL_MEC_5342
has molecule: CHEMBL405821
has target: CHEMBL4305
mechanism description: Intermediate conductance calcium-activated potassium channel protein 4 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4791
type: Mechanism
chembl id: CHEMBL_MEC_4791
has molecule: CHEMBL402548
has target: CHEMBL3430911
mechanism description: Serine/threonine-protein kinase Aurora inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_844
type: Mechanism
chembl id: CHEMBL_MEC_844
has molecule: CHEMBL395429
has target: CHEMBL2049
mechanism description: Oxytocin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_860
type: Mechanism
chembl id: CHEMBL_MEC_860
has molecule: CHEMBL1511
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1058
type: Mechanism
chembl id: CHEMBL_MEC_1058
has molecule: CHEMBL393220
has target: CHEMBL402
mechanism description: HMG-CoA reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1276
type: Mechanism
chembl id: CHEMBL_MEC_1276
has molecule: CHEMBL193
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1833
type: Mechanism
chembl id: CHEMBL_MEC_1833
has molecule: CHEMBL409542
has target: CHEMBL2364096
has binding site: CHEMBL BS 2626
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1834
type: Mechanism
chembl id: CHEMBL_MEC_1834
has molecule: CHEMBL409542
has target: CHEMBL2364103
has binding site: CHEMBL BS 2625
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4835
type: Mechanism
chembl id: CHEMBL_MEC_4835
has molecule: CHEMBL403989
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4834
type: Mechanism
chembl id: CHEMBL_MEC_4834
has molecule: CHEMBL403989
has target: CHEMBL1868
mechanism description: Vascular endothelial growth factor receptor 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4832
type: Mechanism
chembl id: CHEMBL_MEC_4832
has molecule: CHEMBL403989
has target: CHEMBL4142
mechanism description: Fibroblast growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4830
type: Mechanism
chembl id: CHEMBL_MEC_4830
has molecule: CHEMBL403989
has target: CHEMBL5147
mechanism description: Ephrin type-B receptor 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4829
type: Mechanism
chembl id: CHEMBL_MEC_4829
has molecule: CHEMBL403989
has target: CHEMBL2363074
mechanism description: SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4833
type: Mechanism
chembl id: CHEMBL_MEC_4833
has molecule: CHEMBL403989
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4831
type: Mechanism
chembl id: CHEMBL_MEC_4831
has molecule: CHEMBL403989
has target: CHEMBL3650
mechanism description: Fibroblast growth factor receptor 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5575
type: Mechanism
chembl id: CHEMBL_MEC_5575
has molecule: CHEMBL1516
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1426
type: Mechanism
chembl id: CHEMBL_MEC_1426
has molecule: CHEMBL1164
has target: CHEMBL2363021
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5256
type: Mechanism
chembl id: CHEMBL_MEC_5256
has molecule: CHEMBL415049
has target: CHEMBL2185
mechanism description: Serine/threonine-protein kinase Aurora-B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1655
type: Mechanism
chembl id: CHEMBL_MEC_1655
has molecule: CHEMBL1109
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4411
type: Mechanism
chembl id: CHEMBL_MEC_4411
has molecule: CHEMBL405130
has target: CHEMBL2148
mechanism description: Tyrosine-protein kinase JAK3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1145
type: Mechanism
chembl id: CHEMBL_MEC_1145
has molecule: CHEMBL134
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_2279
type: Mechanism
chembl id: CHEMBL_MEC_2279
has molecule: CHEMBL408513
has target: CHEMBL2093865
mechanism description: Histone deacetylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4799
type: Mechanism
chembl id: CHEMBL_MEC_4799
has molecule: CHEMBL411907
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_280
type: Mechanism
chembl id: CHEMBL_MEC_280
has molecule: CHEMBL1092
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1004
type: Mechanism
chembl id: CHEMBL_MEC_1004
has molecule: CHEMBL422330
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5155
type: Mechanism
chembl id: CHEMBL_MEC_5155
has molecule: CHEMBL430497
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1224
type: Mechanism
chembl id: CHEMBL_MEC_1224
has molecule: CHEMBL866
has target: CHEMBL2111369
mechanism description: Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4940
type: Mechanism
chembl id: CHEMBL_MEC_4940
has molecule: CHEMBL426084
has target: CHEMBL233
mechanism description: Mu opioid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1579
type: Mechanism
chembl id: CHEMBL_MEC_1579
has molecule: CHEMBL464
has target: CHEMBL2363071
mechanism description: Retinoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4137
type: Mechanism
chembl id: CHEMBL_MEC_4137
has molecule: CHEMBL422872
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_671
type: Mechanism
chembl id: CHEMBL_MEC_671
has molecule: CHEMBL932
has target: CHEMBL1997
mechanism description: Equilibrative nucleoside transporter 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2260
type: Mechanism
chembl id: CHEMBL_MEC_2260
has molecule: CHEMBL932
has target: CHEMBL2363066
mechanism description: 3',5'-cyclic phosphodiesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4584
type: Mechanism
chembl id: CHEMBL_MEC_4584
has molecule: CHEMBL424133
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1627
type: Mechanism
chembl id: CHEMBL_MEC_1627
has molecule: CHEMBL970
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_157
type: Mechanism
chembl id: CHEMBL_MEC_157
has molecule: CHEMBL1224
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1766
type: Mechanism
chembl id: CHEMBL_MEC_1766
has molecule: CHEMBL1136
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_264
type: Mechanism
chembl id: CHEMBL_MEC_264
has molecule: CHEMBL1251
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4513
type: Mechanism
chembl id: CHEMBL_MEC_4513
has molecule: CHEMBL429317
has target: CHEMBL2492
mechanism description: Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1102
type: Mechanism
chembl id: CHEMBL_MEC_1102
has molecule: CHEMBL428647
has target: CHEMBL2095182
has binding site: CHEMBL BS 2629
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5289
type: Mechanism
chembl id: CHEMBL_MEC_5289
has molecule: CHEMBL428690
has target: CHEMBL2508
mechanism description: Cyclin-dependent kinase 6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5291
type: Mechanism
chembl id: CHEMBL_MEC_5291
has molecule: CHEMBL428690
has target: CHEMBL308
mechanism description: Cyclin-dependent kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5287
type: Mechanism
chembl id: CHEMBL_MEC_5287
has molecule: CHEMBL428690
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5292
type: Mechanism
chembl id: CHEMBL_MEC_5292
has molecule: CHEMBL428690
has target: CHEMBL3055
mechanism description: Cyclin-dependent kinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5290
type: Mechanism
chembl id: CHEMBL_MEC_5290
has molecule: CHEMBL428690
has target: CHEMBL3116
mechanism description: Cyclin-dependent kinase 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5288
type: Mechanism
chembl id: CHEMBL_MEC_5288
has molecule: CHEMBL428690
has target: CHEMBL331
mechanism description: Cyclin-dependent kinase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_814
type: Mechanism
chembl id: CHEMBL_MEC_814
has molecule: CHEMBL1497
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1753
type: Mechanism
chembl id: CHEMBL_MEC_1753
has molecule: CHEMBL1517
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1924
type: Mechanism
chembl id: CHEMBL_MEC_1924
has molecule: CHEMBL922
has target: CHEMBL2362994
mechanism description: DNA polymerase/reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5871
type: Mechanism
chembl id: CHEMBL_MEC_5871
has molecule: CHEMBL429876
has target: CHEMBL2096675
mechanism description: Integrin alpha-V/beta-5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5640
type: Mechanism
chembl id: CHEMBL_MEC_5640
has molecule: CHEMBL429876
has target: CHEMBL1907598
mechanism description: Integrin alpha-V/beta-3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1478
type: Mechanism
chembl id: CHEMBL_MEC_1478
has molecule: CHEMBL1668
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5105
type: Mechanism
chembl id: CHEMBL_MEC_5105
has molecule: CHEMBL448343
has target: CHEMBL2064
mechanism description: GABA-B receptor 1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_5106
type: Mechanism
chembl id: CHEMBL_MEC_5106
has molecule: CHEMBL448343
has target: CHEMBL5034
mechanism description: GABA-B receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1325
type: Mechanism
chembl id: CHEMBL_MEC_1325
has molecule: CHEMBL1200335
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1577
type: Mechanism
chembl id: CHEMBL_MEC_1577
has molecule: CHEMBL705
has target: CHEMBL2363071
mechanism description: Retinoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4942
type: Mechanism
chembl id: CHEMBL_MEC_4942
has molecule: CHEMBL447664
has target: CHEMBL251
mechanism description: Adenosine A2a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5850
type: Mechanism
chembl id: CHEMBL_MEC_5850
has molecule: CHEMBL443684
has target: CHEMBL4625
mechanism description: Apoptosis regulator Bcl-X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5740
type: Mechanism
chembl id: CHEMBL_MEC_5740
has molecule: CHEMBL443684
has target: CHEMBL4860
mechanism description: Apoptosis regulator Bcl-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5851
type: Mechanism
chembl id: CHEMBL_MEC_5851
has molecule: CHEMBL443684
has target: CHEMBL4677
mechanism description: Apoptosis regulator Bcl-W inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2217
type: Mechanism
chembl id: CHEMBL_MEC_2217
has molecule: CHEMBL1576
mechanism description: Unknown

CHEMBL_MEC_1583
type: Mechanism
chembl id: CHEMBL_MEC_1583
has molecule: CHEMBL1614
has target: CHEMBL2095186
has binding site: CHEMBL BS 2653
mechanism description: Sodium/potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4943
type: Mechanism
chembl id: CHEMBL_MEC_4943
has molecule: CHEMBL447955
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1387
type: Mechanism
chembl id: CHEMBL_MEC_1387
has molecule: CHEMBL444633
has target: CHEMBL2364672
has binding site: CHEMBL BS 2638
mechanism description: Bacterial DNA-directed RNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_327
type: Mechanism
chembl id: CHEMBL_MEC_327
has molecule: CHEMBL1200337
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_114
type: Mechanism
chembl id: CHEMBL_MEC_114
has molecule: CHEMBL1560
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1430
type: Mechanism
chembl id: CHEMBL_MEC_1430
has molecule: CHEMBL451887
has target: CHEMBL2364701
has binding site: CHEMBL BS 2633
mechanism description: 26S proteosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_841
type: Mechanism
chembl id: CHEMBL_MEC_841
has molecule: CHEMBL1566
has target: CHEMBL2045
mechanism description: Pancreatic alpha-amylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_873
type: Mechanism
chembl id: CHEMBL_MEC_873
has molecule: CHEMBL1566
has target: CHEMBL2074
mechanism description: Maltase-glucoamylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_522
type: Mechanism
chembl id: CHEMBL_MEC_522
has molecule: CHEMBL1571
has target: CHEMBL1978
mechanism description: Cytochrome P450 19A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_932
type: Mechanism
chembl id: CHEMBL_MEC_932
has molecule: CHEMBL1372
has target: CHEMBL2755
mechanism description: Glutathione reductase

CHEMBL_MEC_4071
type: Mechanism
chembl id: CHEMBL_MEC_4071
has molecule: CHEMBL454138
has target: CHEMBL2047
mechanism description: Bile acid receptor FXR agonist
mechanism action type: AGONIST

CHEMBL_MEC_389
type: Mechanism
chembl id: CHEMBL_MEC_389
has molecule: CHEMBL1580
has target: CHEMBL1910
mechanism description: Adenosine deaminase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4604
type: Mechanism
chembl id: CHEMBL_MEC_4604
has molecule: CHEMBL457748
has target: CHEMBL1947
mechanism description: Thyroid hormone receptor beta-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1742
type: Mechanism
chembl id: CHEMBL_MEC_1742
has molecule: CHEMBL1607
has target: CHEMBL2362989
mechanism description: DNA topoisomerase I, mitochondrial inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1724
type: Mechanism
chembl id: CHEMBL_MEC_1724
has molecule: CHEMBL454446
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1767
type: Mechanism
chembl id: CHEMBL_MEC_1767
has molecule: CHEMBL453087
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1389
type: Mechanism
chembl id: CHEMBL_MEC_1389
has molecule: CHEMBL1617
has target: CHEMBL2364672
has binding site: CHEMBL BS 2638
mechanism description: Bacterial DNA-directed RNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_944
type: Mechanism
chembl id: CHEMBL_MEC_944
has molecule: CHEMBL1200340
has target: CHEMBL3377
mechanism description: Neuraminidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_845
type: Mechanism
chembl id: CHEMBL_MEC_845
has molecule: CHEMBL1200340
has target: CHEMBL2051
mechanism description: Neuraminidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4676
type: Mechanism
chembl id: CHEMBL_MEC_4676
has molecule: CHEMBL460702
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_880
type: Mechanism
chembl id: CHEMBL_MEC_880
has molecule: CHEMBL1574
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_351
type: Mechanism
chembl id: CHEMBL_MEC_351
has molecule: CHEMBL1684
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1449
type: Mechanism
chembl id: CHEMBL_MEC_1449
has molecule: CHEMBL1559
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1812
type: Mechanism
chembl id: CHEMBL_MEC_1812
has molecule: CHEMBL1628
has target: CHEMBL2364031
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1990
type: Mechanism
chembl id: CHEMBL_MEC_1990
has molecule: CHEMBL1200341
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_777
type: Mechanism
chembl id: CHEMBL_MEC_777
has molecule: CHEMBL1200342
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_170
type: Mechanism
chembl id: CHEMBL_MEC_170
has molecule: CHEMBL1633
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1679
type: Mechanism
chembl id: CHEMBL_MEC_1679
has molecule: CHEMBL1618
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_803
type: Mechanism
chembl id: CHEMBL_MEC_803
has molecule: CHEMBL1651
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1574
type: Mechanism
chembl id: CHEMBL_MEC_1574
has molecule: CHEMBL1657
has target: CHEMBL2363069
mechanism description: Retinoic acid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5381
type: Mechanism
chembl id: CHEMBL_MEC_5381
has molecule: CHEMBL462605
has target: CHEMBL264
mechanism description: Histamine H3 receptor inverse agonist
mechanism action type: INVERSE AGONIST

CHEMBL_MEC_4060
type: Mechanism
chembl id: CHEMBL_MEC_4060
has molecule: CHEMBL467888
has target: CHEMBL1871
mechanism description: Androgen Receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_306
type: Mechanism
chembl id: CHEMBL_MEC_306
has molecule: CHEMBL461806
has target: CHEMBL1864
mechanism description: Thrombopoietin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_759
type: Mechanism
chembl id: CHEMBL_MEC_759
has molecule: CHEMBL1670
has target: CHEMBL2033
mechanism description: Cytochrome P450 11A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1369
type: Mechanism
chembl id: CHEMBL_MEC_1369
has molecule: CHEMBL1670
has target: CHEMBL1908
mechanism description: Cytochrome P450 11B1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5728
type: Mechanism
chembl id: CHEMBL_MEC_5728
has molecule: CHEMBL463981
has target: CHEMBL2094135
mechanism description: Gamma-secretase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1555
type: Mechanism
chembl id: CHEMBL_MEC_1555
has molecule: CHEMBL1597
has target: CHEMBL2363053
mechanism description: Heavy metals chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_163
type: Mechanism
chembl id: CHEMBL_MEC_163
has molecule: CHEMBL1653
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4380
type: Mechanism
chembl id: CHEMBL_MEC_4380
has molecule: CHEMBL482767
has target: CHEMBL3430911
mechanism description: Serine/threonine-protein kinase Aurora inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1359
type: Mechanism
chembl id: CHEMBL_MEC_1359
has molecule: CHEMBL1671
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_321
type: Mechanism
chembl id: CHEMBL_MEC_321
has molecule: CHEMBL1671
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2183
type: Mechanism
chembl id: CHEMBL_MEC_2183
has molecule: CHEMBL1584
mechanism description: Unknown

CHEMBL_MEC_1863
type: Mechanism
chembl id: CHEMBL_MEC_1863
has molecule: CHEMBL1585
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_162
type: Mechanism
chembl id: CHEMBL_MEC_162
has molecule: CHEMBL1620
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4944
type: Mechanism
chembl id: CHEMBL_MEC_4944
has molecule: CHEMBL476323
has target: CHEMBL264
mechanism description: Histamine H3 receptor inverse agonist
mechanism action type: INVERSE AGONIST

CHEMBL_MEC_5748
type: Mechanism
chembl id: CHEMBL_MEC_5748
has molecule: CHEMBL490665
has target: CHEMBL237
mechanism description: Kappa opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_596
type: Mechanism
chembl id: CHEMBL_MEC_596
has molecule: CHEMBL1621
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_211
type: Mechanism
chembl id: CHEMBL_MEC_211
has molecule: CHEMBL1621
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_793
type: Mechanism
chembl id: CHEMBL_MEC_793
has molecule: CHEMBL1676
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5258
type: Mechanism
chembl id: CHEMBL_MEC_5258
has molecule: CHEMBL491473
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5259
type: Mechanism
chembl id: CHEMBL_MEC_5259
has molecule: CHEMBL491473
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5257
type: Mechanism
chembl id: CHEMBL_MEC_5257
has molecule: CHEMBL491473
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5821
type: Mechanism
chembl id: CHEMBL_MEC_5821
has molecule: CHEMBL484785
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1716
type: Mechanism
chembl id: CHEMBL_MEC_1716
has molecule: CHEMBL491571
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5722
type: Mechanism
chembl id: CHEMBL_MEC_5722
has molecule: CHEMBL492399
has target: CHEMBL2095182
mechanism description: Tubulin disrupting agent
mechanism action type: DISRUPTING AGENT

CHEMBL_MEC_999
type: Mechanism
chembl id: CHEMBL_MEC_999
has molecule: CHEMBL1630
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4945
type: Mechanism
chembl id: CHEMBL_MEC_4945
has molecule: CHEMBL489095
has target: CHEMBL2203
mechanism description: Motilin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1271
type: Mechanism
chembl id: CHEMBL_MEC_1271
has molecule: CHEMBL1648
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4720
type: Mechanism
chembl id: CHEMBL_MEC_4720
has molecule: CHEMBL482968
has target: CHEMBL1844
mechanism description: Macrophage colony stimulating factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4716
type: Mechanism
chembl id: CHEMBL_MEC_4716
has molecule: CHEMBL482968
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4718
type: Mechanism
chembl id: CHEMBL_MEC_4718
has molecule: CHEMBL482968
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4717
type: Mechanism
chembl id: CHEMBL_MEC_4717
has molecule: CHEMBL482968
has target: CHEMBL2742
mechanism description: Fibroblast growth factor receptor 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4719
type: Mechanism
chembl id: CHEMBL_MEC_4719
has molecule: CHEMBL482968
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4715
type: Mechanism
chembl id: CHEMBL_MEC_4715
has molecule: CHEMBL482968
has target: CHEMBL2185
mechanism description: Serine/threonine-protein kinase Aurora-B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4714
type: Mechanism
chembl id: CHEMBL_MEC_4714
has molecule: CHEMBL482968
has target: CHEMBL4722
mechanism description: Serine/threonine-protein kinase Aurora-A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_451
type: Mechanism
chembl id: CHEMBL_MEC_451
has molecule: CHEMBL1642
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_304
type: Mechanism
chembl id: CHEMBL_MEC_304
has molecule: CHEMBL1642
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_418
type: Mechanism
chembl id: CHEMBL_MEC_418
has molecule: CHEMBL1642
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1311
type: Mechanism
chembl id: CHEMBL_MEC_1311
has molecule: CHEMBL511142
has target: CHEMBL237
mechanism description: Kappa opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_733
type: Mechanism
chembl id: CHEMBL_MEC_733
has molecule: CHEMBL511142
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_148
type: Mechanism
chembl id: CHEMBL_MEC_148
has molecule: CHEMBL1659
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1539
type: Mechanism
chembl id: CHEMBL_MEC_1539
has molecule: CHEMBL1687
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4429
type: Mechanism
chembl id: CHEMBL_MEC_4429
has molecule: CHEMBL1206245
has target: CHEMBL3610
mechanism description: G1/S-specific cyclin D1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_349
type: Mechanism
chembl id: CHEMBL_MEC_349
has molecule: CHEMBL1577
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4946
type: Mechanism
chembl id: CHEMBL_MEC_4946
has molecule: CHEMBL514270
has target: CHEMBL1800
mechanism description: Corticotropin releasing factor receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1108
type: Mechanism
chembl id: CHEMBL_MEC_1108
has molecule: CHEMBL501867
has target: CHEMBL2095182
has binding site: CHEMBL BS 2627
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5078
type: Mechanism
chembl id: CHEMBL_MEC_5078
has molecule: CHEMBL522302
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5586
type: Mechanism
chembl id: CHEMBL_MEC_5586
has molecule: CHEMBL512351
has target: CHEMBL244
mechanism description: Coagulation factor X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2020
type: Mechanism
chembl id: CHEMBL_MEC_2020
has molecule: CHEMBL1616
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5228
type: Mechanism
chembl id: CHEMBL_MEC_5228
has molecule: CHEMBL519504
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5227
type: Mechanism
chembl id: CHEMBL_MEC_5227
has molecule: CHEMBL519504
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1510
type: Mechanism
chembl id: CHEMBL_MEC_1510
has molecule: CHEMBL517712
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_31
type: Mechanism
chembl id: CHEMBL_MEC_31
has molecule: CHEMBL517712
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_289
type: Mechanism
chembl id: CHEMBL_MEC_289
has molecule: CHEMBL517712
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4783
type: Mechanism
chembl id: CHEMBL_MEC_4783
has molecule: CHEMBL507361
has target: CHEMBL2964
mechanism description: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4782
type: Mechanism
chembl id: CHEMBL_MEC_4782
has molecule: CHEMBL507361
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_946
type: Mechanism
chembl id: CHEMBL_MEC_946
has molecule: CHEMBL518520
has target: CHEMBL3471
mechanism description: Human immunodeficiency virus type 1 integrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_741
type: Mechanism
chembl id: CHEMBL_MEC_741
has molecule: CHEMBL1555
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_804
type: Mechanism
chembl id: CHEMBL_MEC_804
has molecule: CHEMBL1683
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2320
type: Mechanism
chembl id: CHEMBL_MEC_2320
has molecule: CHEMBL521686
has target: CHEMBL3390820
mechanism description: PARP 1, 2 & 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1006
type: Mechanism
chembl id: CHEMBL_MEC_1006
has molecule: CHEMBL1643
has target: CHEMBL5375
mechanism description: Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1580
type: Mechanism
chembl id: CHEMBL_MEC_1580
has molecule: CHEMBL1643
has target: CHEMBL2363073
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_126
type: Mechanism
chembl id: CHEMBL_MEC_126
has molecule: CHEMBL1643
has target: CHEMBL1822
mechanism description: Inosine-5'-monophosphate dehydrogenase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_394
type: Mechanism
chembl id: CHEMBL_MEC_394
has molecule: CHEMBL1708
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5129
type: Mechanism
chembl id: CHEMBL_MEC_5129
has molecule: CHEMBL1207366
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1967
type: Mechanism
chembl id: CHEMBL_MEC_1967
has molecule: CHEMBL1611
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1914
type: Mechanism
chembl id: CHEMBL_MEC_1914
has molecule: CHEMBL544665
has target: CHEMBL2363041
mechanism description: Sphingosine 1-phosphate receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_113
type: Mechanism
chembl id: CHEMBL_MEC_113
has molecule: CHEMBL1694
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1368
type: Mechanism
chembl id: CHEMBL_MEC_1368
has molecule: CHEMBL1695
has target: CHEMBL1903
mechanism description: GABA transporter 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_690
type: Mechanism
chembl id: CHEMBL_MEC_690
has molecule: CHEMBL1698
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_907
type: Mechanism
chembl id: CHEMBL_MEC_907
has molecule: CHEMBL1698
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1361
type: Mechanism
chembl id: CHEMBL_MEC_1361
has molecule: CHEMBL1700
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_323
type: Mechanism
chembl id: CHEMBL_MEC_323
has molecule: CHEMBL1700
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_504
type: Mechanism
chembl id: CHEMBL_MEC_504
has molecule: CHEMBL1700
has target: CHEMBL240
mechanism description: HERG blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1142
type: Mechanism
chembl id: CHEMBL_MEC_1142
has molecule: CHEMBL1705
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_422
type: Mechanism
chembl id: CHEMBL_MEC_422
has molecule: CHEMBL1715
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5019
type: Mechanism
chembl id: CHEMBL_MEC_5019
has molecule: CHEMBL541758
has target: CHEMBL3157
mechanism description: Bradykinin B2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_399
type: Mechanism
chembl id: CHEMBL_MEC_399
has molecule: CHEMBL1709
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1079
type: Mechanism
chembl id: CHEMBL_MEC_1079
has molecule: CHEMBL1704
has target: CHEMBL2093869
mechanism description: Integrin alpha-IIb/beta-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2009
type: Mechanism
chembl id: CHEMBL_MEC_2009
has molecule: CHEMBL542257
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_706
type: Mechanism
chembl id: CHEMBL_MEC_706
has molecule: CHEMBL1707
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1740
type: Mechanism
chembl id: CHEMBL_MEC_1740
has molecule: CHEMBL525076
has target: CHEMBL2362987
mechanism description: Transmembrane glycoprotein gp41 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1845
type: Mechanism
chembl id: CHEMBL_MEC_1845
has molecule: CHEMBL1554
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_35
type: Mechanism
chembl id: CHEMBL_MEC_35
has molecule: CHEMBL551466
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1129
type: Mechanism
chembl id: CHEMBL_MEC_1129
has molecule: CHEMBL1699
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5045
type: Mechanism
chembl id: CHEMBL_MEC_5045
has molecule: CHEMBL539843
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1744
type: Mechanism
chembl id: CHEMBL_MEC_1744
has molecule: CHEMBL1542
has target: CHEMBL2362992
mechanism description: Amidophosphoribosyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1874
type: Mechanism
chembl id: CHEMBL_MEC_1874
has molecule: CHEMBL1542
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2006
type: Mechanism
chembl id: CHEMBL_MEC_2006
has molecule: CHEMBL1713
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_578
type: Mechanism
chembl id: CHEMBL_MEC_578
has molecule: CHEMBL1713
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1272
type: Mechanism
chembl id: CHEMBL_MEC_1272
has molecule: CHEMBL1697
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2370
type: Mechanism
chembl id: CHEMBL_MEC_2370
has molecule: CHEMBL1703
has target: CHEMBL3391681
mechanism description: Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1570
type: Mechanism
chembl id: CHEMBL_MEC_1570
has molecule: CHEMBL1703
has target: CHEMBL2363065
mechanism description: Mitochondrial complex I (NADH dehydrogenase) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1234
type: Mechanism
chembl id: CHEMBL_MEC_1234
has molecule: CHEMBL1706
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_5005
type: Mechanism
chembl id: CHEMBL_MEC_5005
has molecule: CHEMBL539423
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5004
type: Mechanism
chembl id: CHEMBL_MEC_5004
has molecule: CHEMBL539423
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1192
type: Mechanism
chembl id: CHEMBL_MEC_1192
has molecule: CHEMBL6
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2421
type: Mechanism
chembl id: CHEMBL_MEC_2421
has molecule: CHEMBL2364637
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_187
type: Mechanism
chembl id: CHEMBL_MEC_187
has molecule: CHEMBL1737
has target: CHEMBL1827
mechanism description: Phosphodiesterase 5A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2151
type: Mechanism
chembl id: CHEMBL_MEC_2151
has molecule: CHEMBL1746
has target: CHEMBL2366039
mechanism description: Glutamine sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_2177
type: Mechanism
chembl id: CHEMBL_MEC_2177
has molecule: CHEMBL567597
mechanism description: Unknown

CHEMBL_MEC_4103
type: Mechanism
chembl id: CHEMBL_MEC_4103
has molecule: CHEMBL551064
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5354
type: Mechanism
chembl id: CHEMBL_MEC_5354
has molecule: CHEMBL562668
has target: CHEMBL218
mechanism description: Cannabinoid CB1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1562
type: Mechanism
chembl id: CHEMBL_MEC_1562
has molecule: CHEMBL550348
has target: CHEMBL2363058
mechanism description: Iron chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1001
type: Mechanism
chembl id: CHEMBL_MEC_1001
has molecule: CHEMBL566534
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4674
type: Mechanism
chembl id: CHEMBL_MEC_4674
has molecule: CHEMBL575448
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4675
type: Mechanism
chembl id: CHEMBL_MEC_4675
has molecule: CHEMBL575448
has target: CHEMBL1981
mechanism description: Insulin receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1915
type: Mechanism
chembl id: CHEMBL_MEC_1915
has molecule: CHEMBL1750
has target: CHEMBL2363042
mechanism description: DNA polymerase (alpha/delta/epsilon) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1259
type: Mechanism
chembl id: CHEMBL_MEC_1259
has molecule: CHEMBL1750
has target: CHEMBL2095215
has binding site: CHEMBL BS 2652
mechanism description: Ribonucleoside-diphosphate reductase RR1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1879
type: Mechanism
chembl id: CHEMBL_MEC_1879
has molecule: CHEMBL1750
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1281
type: Mechanism
chembl id: CHEMBL_MEC_1281
has molecule: CHEMBL1726
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1125
type: Mechanism
chembl id: CHEMBL_MEC_1125
has molecule: CHEMBL1711
has target: CHEMBL2094118
mechanism description: Adrenergic receptor beta agonist
mechanism action type: AGONIST

CHEMBL_MEC_2073
type: Mechanism
chembl id: CHEMBL_MEC_2073
has molecule: CHEMBL1747
has target: CHEMBL2364022
has binding site: CHEMBL BS 2624
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1908
type: Mechanism
chembl id: CHEMBL_MEC_1908
has molecule: CHEMBL1728
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4792
type: Mechanism
chembl id: CHEMBL_MEC_4792
has molecule: CHEMBL564829
has target: CHEMBL308
mechanism description: Cyclin-dependent kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4795
type: Mechanism
chembl id: CHEMBL_MEC_4795
has molecule: CHEMBL564829
has target: CHEMBL2815
mechanism description: Nerve growth factor receptor Trk-A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4794
type: Mechanism
chembl id: CHEMBL_MEC_4794
has molecule: CHEMBL564829
has target: CHEMBL331
mechanism description: Cyclin-dependent kinase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4793
type: Mechanism
chembl id: CHEMBL_MEC_4793
has molecule: CHEMBL564829
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5221
type: Mechanism
chembl id: CHEMBL_MEC_5221
has molecule: CHEMBL566315
has target: CHEMBL2047
mechanism description: Bile acid receptor FXR agonist
mechanism action type: AGONIST

CHEMBL_MEC_5249
type: Mechanism
chembl id: CHEMBL_MEC_5249
has molecule: CHEMBL576982
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5252
type: Mechanism
chembl id: CHEMBL_MEC_5252
has molecule: CHEMBL576982
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5251
type: Mechanism
chembl id: CHEMBL_MEC_5251
has molecule: CHEMBL576982
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5248
type: Mechanism
chembl id: CHEMBL_MEC_5248
has molecule: CHEMBL576982
has target: CHEMBL1844
mechanism description: Macrophage colony stimulating factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5250
type: Mechanism
chembl id: CHEMBL_MEC_5250
has molecule: CHEMBL576982
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4764
type: Mechanism
chembl id: CHEMBL_MEC_4764
has molecule: CHEMBL572878
has target: CHEMBL3430911
mechanism description: Serine/threonine-protein kinase Aurora inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2182
type: Mechanism
chembl id: CHEMBL_MEC_2182
has molecule: CHEMBL1749
has target: CHEMBL2364030
mechanism description: Calcium chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_352
type: Mechanism
chembl id: CHEMBL_MEC_352
has molecule: CHEMBL1763
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4751
type: Mechanism
chembl id: CHEMBL_MEC_4751
has molecule: CHEMBL571546
has target: CHEMBL267
mechanism description: Tyrosine-protein kinase SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5044
type: Mechanism
chembl id: CHEMBL_MEC_5044
has molecule: CHEMBL582857
has target: CHEMBL1921
mechanism description: Vasopressin V1b receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1441
type: Mechanism
chembl id: CHEMBL_MEC_1441
has molecule: CHEMBL1690
has target: CHEMBL5936
mechanism description: Toll-like receptor 7 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1005
type: Mechanism
chembl id: CHEMBL_MEC_1005
has molecule: CHEMBL1690
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1582
type: Mechanism
chembl id: CHEMBL_MEC_1582
has molecule: CHEMBL1690
has target: CHEMBL5804
mechanism description: Toll-like receptor 9 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_794
type: Mechanism
chembl id: CHEMBL_MEC_794
has molecule: CHEMBL1766
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_454
type: Mechanism
chembl id: CHEMBL_MEC_454
has molecule: CHEMBL588912
has target: CHEMBL1939
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_28
type: Mechanism
chembl id: CHEMBL_MEC_28
has molecule: CHEMBL1768
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1507
type: Mechanism
chembl id: CHEMBL_MEC_1507
has molecule: CHEMBL1768
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_4606
type: Mechanism
chembl id: CHEMBL_MEC_4606
has molecule: CHEMBL605525
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4788
type: Mechanism
chembl id: CHEMBL_MEC_4788
has molecule: CHEMBL592445
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4787
type: Mechanism
chembl id: CHEMBL_MEC_4787
has molecule: CHEMBL592445
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5203
type: Mechanism
chembl id: CHEMBL_MEC_5203
has molecule: CHEMBL593430
has target: CHEMBL2363032
mechanism description: Voltage-gated calcium channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_955
type: Mechanism
chembl id: CHEMBL_MEC_955
has molecule: CHEMBL601719
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_973
type: Mechanism
chembl id: CHEMBL_MEC_973
has molecule: CHEMBL601719
has target: CHEMBL4247
mechanism description: ALK tyrosine kinase receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1714
type: Mechanism
chembl id: CHEMBL_MEC_1714
has molecule: CHEMBL606260
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1331
type: Mechanism
chembl id: CHEMBL_MEC_1331
has molecule: CHEMBL1082407
has target: CHEMBL1871
mechanism description: Androgen Receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4643
type: Mechanism
chembl id: CHEMBL_MEC_4643
has molecule: CHEMBL1078983
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1656
type: Mechanism
chembl id: CHEMBL_MEC_1656
has molecule: CHEMBL1200351
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4342
type: Mechanism
chembl id: CHEMBL_MEC_4342
has molecule: CHEMBL384304
has target: CHEMBL331
mechanism description: Cyclin-dependent kinase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4340
type: Mechanism
chembl id: CHEMBL_MEC_4340
has molecule: CHEMBL384304
has target: CHEMBL308
mechanism description: Cyclin-dependent kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4341
type: Mechanism
chembl id: CHEMBL_MEC_4341
has molecule: CHEMBL384304
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4713
type: Mechanism
chembl id: CHEMBL_MEC_4713
has molecule: CHEMBL607707
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2168
type: Mechanism
chembl id: CHEMBL_MEC_2168
has molecule: CHEMBL607710
mechanism description: Unknown

CHEMBL_MEC_5274
type: Mechanism
chembl id: CHEMBL_MEC_5274
has molecule: CHEMBL603469
has target: CHEMBL4898
mechanism description: Neurotrophic tyrosine kinase receptor type 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5276
type: Mechanism
chembl id: CHEMBL_MEC_5276
has molecule: CHEMBL603469
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5271
type: Mechanism
chembl id: CHEMBL_MEC_5271
has molecule: CHEMBL603469
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5275
type: Mechanism
chembl id: CHEMBL_MEC_5275
has molecule: CHEMBL603469
has target: CHEMBL5608
mechanism description: NT-3 growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5273
type: Mechanism
chembl id: CHEMBL_MEC_5273
has molecule: CHEMBL603469
has target: CHEMBL2815
mechanism description: Nerve growth factor receptor Trk-A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5272
type: Mechanism
chembl id: CHEMBL_MEC_5272
has molecule: CHEMBL603469
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1984
type: Mechanism
chembl id: CHEMBL_MEC_1984
has molecule: CHEMBL1769
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_243
type: Mechanism
chembl id: CHEMBL_MEC_243
has molecule: CHEMBL1079742
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5922
type: Mechanism
chembl id: CHEMBL_MEC_5922
has molecule: CHEMBL1094636
has target: CHEMBL3105
mechanism description: Poly [ADP-ribose] polymerase-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5681
type: Mechanism
chembl id: CHEMBL_MEC_5681
has molecule: CHEMBL1094636
has target: CHEMBL5366
mechanism description: Poly [ADP-ribose] polymerase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5056
type: Mechanism
chembl id: CHEMBL_MEC_5056
has molecule: CHEMBL1094785
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4801
type: Mechanism
chembl id: CHEMBL_MEC_4801
has molecule: CHEMBL1090089
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5318
type: Mechanism
chembl id: CHEMBL_MEC_5318
has molecule: CHEMBL608533
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5317
type: Mechanism
chembl id: CHEMBL_MEC_5317
has molecule: CHEMBL608533
has target: CHEMBL2093867
mechanism description: Protein kinase C (PKC) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5315
type: Mechanism
chembl id: CHEMBL_MEC_5315
has molecule: CHEMBL608533
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5316
type: Mechanism
chembl id: CHEMBL_MEC_5316
has molecule: CHEMBL608533
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5314
type: Mechanism
chembl id: CHEMBL_MEC_5314
has molecule: CHEMBL608533
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2285
type: Mechanism
chembl id: CHEMBL_MEC_2285
has molecule: CHEMBL1083659
has target: CHEMBL3307226
mechanism description: Orexin receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2295
type: Mechanism
chembl id: CHEMBL_MEC_2295
has molecule: CHEMBL373742
has target: CHEMBL2363078
mechanism description: Vasopressin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5008
type: Mechanism
chembl id: CHEMBL_MEC_5008
has molecule: CHEMBL1096146
has target: CHEMBL4333
mechanism description: Sphingosine 1-phosphate receptor Edg-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1890
type: Mechanism
chembl id: CHEMBL_MEC_1890
has molecule: CHEMBL1096885
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_104
type: Mechanism
chembl id: CHEMBL_MEC_104
has molecule: CHEMBL1096885
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4375
type: Mechanism
chembl id: CHEMBL_MEC_4375
has molecule: CHEMBL1090173
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4709
type: Mechanism
chembl id: CHEMBL_MEC_4709
has molecule: CHEMBL1097999
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4710
type: Mechanism
chembl id: CHEMBL_MEC_4710
has molecule: CHEMBL1097999
has target: CHEMBL3956
mechanism description: Mitogen-activated protein kinase kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4846
type: Mechanism
chembl id: CHEMBL_MEC_4846
has molecule: CHEMBL1090090
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2355
type: Mechanism
chembl id: CHEMBL_MEC_2355
has molecule: CHEMBL1213250
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5669
type: Mechanism
chembl id: CHEMBL_MEC_5669
has molecule: CHEMBL1095032
has target: CHEMBL244
mechanism description: Coagulation factor X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4409
type: Mechanism
chembl id: CHEMBL_MEC_4409
has molecule: CHEMBL1079593
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4408
type: Mechanism
chembl id: CHEMBL_MEC_4408
has molecule: CHEMBL1079593
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_502
type: Mechanism
chembl id: CHEMBL_MEC_502
has molecule: CHEMBL1083993
has target: CHEMBL240
mechanism description: HERG blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1688
type: Mechanism
chembl id: CHEMBL_MEC_1688
has molecule: CHEMBL1095930
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4627
type: Mechanism
chembl id: CHEMBL_MEC_4627
has molecule: CHEMBL1088750
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5255
type: Mechanism
chembl id: CHEMBL_MEC_5255
has molecule: CHEMBL217092
has target: CHEMBL267
mechanism description: Tyrosine-protein kinase SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5254
type: Mechanism
chembl id: CHEMBL_MEC_5254
has molecule: CHEMBL217092
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4220
type: Mechanism
chembl id: CHEMBL_MEC_4220
has molecule: CHEMBL1090479
has target: CHEMBL2185
mechanism description: Serine/threonine-protein kinase Aurora-B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4221
type: Mechanism
chembl id: CHEMBL_MEC_4221
has molecule: CHEMBL1090479
has target: CHEMBL3935
mechanism description: Serine/threonine-protein kinase Aurora-C inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1209
type: Mechanism
chembl id: CHEMBL_MEC_1209
has molecule: CHEMBL44657
has target: CHEMBL2094255
mechanism description: DNA topoisomerase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1805
type: Mechanism
chembl id: CHEMBL_MEC_1805
has molecule: CHEMBL229383
has target: CHEMBL2364028
mechanism description: Ergosterol sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_4294
type: Mechanism
chembl id: CHEMBL_MEC_4294
has molecule: CHEMBL1094408
has target: CHEMBL3024
mechanism description: Serine/threonine-protein kinase PLK1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_438
type: Mechanism
chembl id: CHEMBL_MEC_438
has molecule: CHEMBL1164729
has target: CHEMBL1929
mechanism description: Xanthine dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1705
type: Mechanism
chembl id: CHEMBL_MEC_1705
has molecule: CHEMBL1644
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_3892
type: Mechanism
chembl id: CHEMBL_MEC_3892
has molecule: CHEMBL216981
has target: CHEMBL2434
mechanism description: Interleukin-8 receptor B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1881
type: Mechanism
chembl id: CHEMBL_MEC_1881
has molecule: CHEMBL1773
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1891
type: Mechanism
chembl id: CHEMBL_MEC_1891
has molecule: CHEMBL1773
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_485
type: Mechanism
chembl id: CHEMBL_MEC_485
has molecule: CHEMBL1773
has target: CHEMBL1952
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5743
type: Mechanism
chembl id: CHEMBL_MEC_5743
has molecule: CHEMBL1215923
has target: CHEMBL3831288
mechanism description: Selectin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5726
type: Mechanism
chembl id: CHEMBL_MEC_5726
has molecule: CHEMBL1169880
has target: CHEMBL2337
mechanism description: Glycine transporter 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2235
type: Mechanism
chembl id: CHEMBL_MEC_2235
has molecule: CHEMBL1213165
has target: CHEMBL3471
mechanism description: Human immunodeficiency virus type 1 integrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_291
type: Mechanism
chembl id: CHEMBL_MEC_291
has molecule: CHEMBL1187846
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1347
type: Mechanism
chembl id: CHEMBL_MEC_1347
has molecule: CHEMBL1160544
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_859
type: Mechanism
chembl id: CHEMBL_MEC_859
has molecule: CHEMBL1200430
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_210
type: Mechanism
chembl id: CHEMBL_MEC_210
has molecule: CHEMBL1200419
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_592
type: Mechanism
chembl id: CHEMBL_MEC_592
has molecule: CHEMBL1200419
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_969
type: Mechanism
chembl id: CHEMBL_MEC_969
has molecule: CHEMBL1201821
has target: CHEMBL4142
mechanism description: Fibroblast growth factor receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_56
type: Mechanism
chembl id: CHEMBL_MEC_56
has molecule: CHEMBL1201825
has target: CHEMBL1783
mechanism description: Vascular endothelial growth factor A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1397
type: Mechanism
chembl id: CHEMBL_MEC_1397
has molecule: CHEMBL1201826
has target: CHEMBL2364677
mechanism description: Heparan sulfate hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_1289
type: Mechanism
chembl id: CHEMBL_MEC_1289
has molecule: CHEMBL1201830
has target: CHEMBL1909490
mechanism description: Interleukin-1 beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_181
type: Mechanism
chembl id: CHEMBL_MEC_181
has molecule: CHEMBL1201831
has target: CHEMBL1825
mechanism description: TNF-alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_184
type: Mechanism
chembl id: CHEMBL_MEC_184
has molecule: CHEMBL1201833
has target: CHEMBL1825
mechanism description: TNF-alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1288
type: Mechanism
chembl id: CHEMBL_MEC_1288
has molecule: CHEMBL1201834
has target: CHEMBL1909490
mechanism description: Interleukin-1 beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_673
type: Mechanism
chembl id: CHEMBL_MEC_673
has molecule: CHEMBL1201837
has target: CHEMBL2000
mechanism description: Plasma kallikrein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2193
type: Mechanism
chembl id: CHEMBL_MEC_2193
has molecule: CHEMBL1200358
has target: CHEMBL2366039
mechanism description: Glutamine sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_1976
type: Mechanism
chembl id: CHEMBL_MEC_1976
has molecule: CHEMBL1200440
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_100
type: Mechanism
chembl id: CHEMBL_MEC_100
has molecule: CHEMBL1200475
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1876
type: Mechanism
chembl id: CHEMBL_MEC_1876
has molecule: CHEMBL1200475
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_437
type: Mechanism
chembl id: CHEMBL_MEC_437
has molecule: CHEMBL1200477
has target: CHEMBL1929
mechanism description: Xanthine dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_72
type: Mechanism
chembl id: CHEMBL_MEC_72
has molecule: CHEMBL1200681
has target: CHEMBL1798
mechanism description: Cysteinyl leukotriene receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_260
type: Mechanism
chembl id: CHEMBL_MEC_260
has molecule: CHEMBL1200501
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1758
type: Mechanism
chembl id: CHEMBL_MEC_1758
has molecule: CHEMBL1200510
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_54
type: Mechanism
chembl id: CHEMBL_MEC_54
has molecule: CHEMBL1200512
has target: CHEMBL1781
mechanism description: DNA topoisomerase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_745
type: Mechanism
chembl id: CHEMBL_MEC_745
has molecule: CHEMBL1200514
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1188
type: Mechanism
chembl id: CHEMBL_MEC_1188
has molecule: CHEMBL1200613
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_139
type: Mechanism
chembl id: CHEMBL_MEC_139
has molecule: CHEMBL1200750
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1745
type: Mechanism
chembl id: CHEMBL_MEC_1745
has molecule: CHEMBL1200751
has target: CHEMBL2362992
mechanism description: Amidophosphoribosyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1885
type: Mechanism
chembl id: CHEMBL_MEC_1885
has molecule: CHEMBL1200751
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1528
type: Mechanism
chembl id: CHEMBL_MEC_1528
has molecule: CHEMBL1200757
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1456
type: Mechanism
chembl id: CHEMBL_MEC_1456
has molecule: CHEMBL1200836
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_774
type: Mechanism
chembl id: CHEMBL_MEC_774
has molecule: CHEMBL1200909
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_894
type: Mechanism
chembl id: CHEMBL_MEC_894
has molecule: CHEMBL1200992
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1482
type: Mechanism
chembl id: CHEMBL_MEC_1482
has molecule: CHEMBL1200992
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_696
type: Mechanism
chembl id: CHEMBL_MEC_696
has molecule: CHEMBL1200992
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1530
type: Mechanism
chembl id: CHEMBL_MEC_1530
has molecule: CHEMBL1200993
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1774
type: Mechanism
chembl id: CHEMBL_MEC_1774
has molecule: CHEMBL1201071
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1651
type: Mechanism
chembl id: CHEMBL_MEC_1651
has molecule: CHEMBL1200910
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2192
type: Mechanism
chembl id: CHEMBL_MEC_2192
has molecule: CHEMBL1201154
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1524
type: Mechanism
chembl id: CHEMBL_MEC_1524
has molecule: CHEMBL1201733
has target: CHEMBL2959
mechanism description: Tyrosine-protein kinase ITK/TSK inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1116
type: Mechanism
chembl id: CHEMBL_MEC_1116
has molecule: CHEMBL1201733
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_950
type: Mechanism
chembl id: CHEMBL_MEC_950
has molecule: CHEMBL1201733
has target: CHEMBL3650
mechanism description: Fibroblast growth factor receptor 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1267
type: Mechanism
chembl id: CHEMBL_MEC_1267
has molecule: CHEMBL1201733
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_931
type: Mechanism
chembl id: CHEMBL_MEC_931
has molecule: CHEMBL1201733
has target: CHEMBL2742
mechanism description: Fibroblast growth factor receptor 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_840
type: Mechanism
chembl id: CHEMBL_MEC_840
has molecule: CHEMBL1201733
has target: CHEMBL258
mechanism description: Tyrosine-protein kinase LCK inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_235
type: Mechanism
chembl id: CHEMBL_MEC_235
has molecule: CHEMBL1201733
has target: CHEMBL1844
mechanism description: Macrophage colony stimulating factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_447
type: Mechanism
chembl id: CHEMBL_MEC_447
has molecule: CHEMBL1201733
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_789
type: Mechanism
chembl id: CHEMBL_MEC_789
has molecule: CHEMBL1201064
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1964
type: Mechanism
chembl id: CHEMBL_MEC_1964
has molecule: CHEMBL1200478
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1228
type: Mechanism
chembl id: CHEMBL_MEC_1228
has molecule: CHEMBL1200480
has target: CHEMBL2111436
mechanism description: Somatostatin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1830
type: Mechanism
chembl id: CHEMBL_MEC_1830
has molecule: CHEMBL1200596
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1978
type: Mechanism
chembl id: CHEMBL_MEC_1978
has molecule: CHEMBL1200597
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_770
type: Mechanism
chembl id: CHEMBL_MEC_770
has molecule: CHEMBL1200600
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_915
type: Mechanism
chembl id: CHEMBL_MEC_915
has molecule: CHEMBL1200724
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_2103
type: Mechanism
chembl id: CHEMBL_MEC_2103
has molecule: CHEMBL1200728
has target: CHEMBL2362996
mechanism description: Voltage-gated potassium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1731
type: Mechanism
chembl id: CHEMBL_MEC_1731
has molecule: CHEMBL1200820
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_527
type: Mechanism
chembl id: CHEMBL_MEC_527
has molecule: CHEMBL1200822
has target: CHEMBL1980
mechanism description: Sodium channel protein type V alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1241
type: Mechanism
chembl id: CHEMBL_MEC_1241
has molecule: CHEMBL1200895
has target: CHEMBL2095205
mechanism description: Monoamine oxidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_436
type: Mechanism
chembl id: CHEMBL_MEC_436
has molecule: CHEMBL1200978
has target: CHEMBL1927
mechanism description: Thioredoxin reductase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1604
type: Mechanism
chembl id: CHEMBL_MEC_1604
has molecule: CHEMBL1200982
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_866
type: Mechanism
chembl id: CHEMBL_MEC_866
has molecule: CHEMBL1201151
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1352
type: Mechanism
chembl id: CHEMBL_MEC_1352
has molecule: CHEMBL1201153
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_571
type: Mechanism
chembl id: CHEMBL_MEC_571
has molecule: CHEMBL1200521
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_368
type: Mechanism
chembl id: CHEMBL_MEC_368
has molecule: CHEMBL1200521
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_97
type: Mechanism
chembl id: CHEMBL_MEC_97
has molecule: CHEMBL1200521
has target: CHEMBL1805
mechanism description: Serotonin 1f (5-HT1f) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_798
type: Mechanism
chembl id: CHEMBL_MEC_798
has molecule: CHEMBL1200732
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1919
type: Mechanism
chembl id: CHEMBL_MEC_1919
has molecule: CHEMBL1200382
has target: CHEMBL2363032
mechanism description: Voltage-gated calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1983
type: Mechanism
chembl id: CHEMBL_MEC_1983
has molecule: CHEMBL1200464
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1996
type: Mechanism
chembl id: CHEMBL_MEC_1996
has molecule: CHEMBL1200323
has target: CHEMBL2331074
mechanism description: Adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2388
type: Mechanism
chembl id: CHEMBL_MEC_2388
has molecule: CHEMBL1200434
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2389
type: Mechanism
chembl id: CHEMBL_MEC_2389
has molecule: CHEMBL1200434
has target: CHEMBL2094125
mechanism description: Phosphodiesterase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2390
type: Mechanism
chembl id: CHEMBL_MEC_2390
has molecule: CHEMBL1200434
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1672
type: Mechanism
chembl id: CHEMBL_MEC_1672
has molecule: CHEMBL1200424
has target: CHEMBL2366037
mechanism description: Radioactive metals chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1143
type: Mechanism
chembl id: CHEMBL_MEC_1143
has molecule: CHEMBL1200432
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1455
type: Mechanism
chembl id: CHEMBL_MEC_1455
has molecule: CHEMBL1200398
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_469
type: Mechanism
chembl id: CHEMBL_MEC_469
has molecule: CHEMBL1200399
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_1203
type: Mechanism
chembl id: CHEMBL_MEC_1203
has molecule: CHEMBL1201141
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1702
type: Mechanism
chembl id: CHEMBL_MEC_1702
has molecule: CHEMBL1200482
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_994
type: Mechanism
chembl id: CHEMBL_MEC_994
has molecule: CHEMBL1200485
has target: CHEMBL5145
mechanism description: Serine/threonine-protein kinase B-raf inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1517
type: Mechanism
chembl id: CHEMBL_MEC_1517
has molecule: CHEMBL1200485
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1266
type: Mechanism
chembl id: CHEMBL_MEC_1266
has molecule: CHEMBL1200485
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_510
type: Mechanism
chembl id: CHEMBL_MEC_510
has molecule: CHEMBL1200485
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_388
type: Mechanism
chembl id: CHEMBL_MEC_388
has molecule: CHEMBL1200485
has target: CHEMBL1906
mechanism description: Serine/threonine-protein kinase RAF inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_417
type: Mechanism
chembl id: CHEMBL_MEC_417
has molecule: CHEMBL1200485
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_449
type: Mechanism
chembl id: CHEMBL_MEC_449
has molecule: CHEMBL1200485
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2186
type: Mechanism
chembl id: CHEMBL_MEC_2186
has molecule: CHEMBL1200922
mechanism description: Unknown

CHEMBL_MEC_1165
type: Mechanism
chembl id: CHEMBL_MEC_1165
has molecule: CHEMBL1201167
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1121
type: Mechanism
chembl id: CHEMBL_MEC_1121
has molecule: CHEMBL1201167
has target: CHEMBL2094118
mechanism description: Adrenergic receptor beta antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_621
type: Mechanism
chembl id: CHEMBL_MEC_621
has molecule: CHEMBL1201741
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_595
type: Mechanism
chembl id: CHEMBL_MEC_595
has molecule: CHEMBL1201741
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2008
type: Mechanism
chembl id: CHEMBL_MEC_2008
has molecule: CHEMBL1201741
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_108
type: Mechanism
chembl id: CHEMBL_MEC_108
has molecule: CHEMBL1200534
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_313
type: Mechanism
chembl id: CHEMBL_MEC_313
has molecule: CHEMBL1200745
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1356
type: Mechanism
chembl id: CHEMBL_MEC_1356
has molecule: CHEMBL1200745
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1850
type: Mechanism
chembl id: CHEMBL_MEC_1850
has molecule: CHEMBL1200981
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1213
type: Mechanism
chembl id: CHEMBL_MEC_1213
has molecule: CHEMBL1200569
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_879
type: Mechanism
chembl id: CHEMBL_MEC_879
has molecule: CHEMBL1200594
has target: CHEMBL222
mechanism description: Norepinephrine transporter substrate
mechanism action type: SUBSTRATE

CHEMBL_MEC_1912
type: Mechanism
chembl id: CHEMBL_MEC_1912
has molecule: CHEMBL1200621
has target: CHEMBL2311225
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2044
type: Mechanism
chembl id: CHEMBL_MEC_2044
has molecule: CHEMBL1200621
has target: CHEMBL2363033
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_36
type: Mechanism
chembl id: CHEMBL_MEC_36
has molecule: CHEMBL1200764
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_744
type: Mechanism
chembl id: CHEMBL_MEC_744
has molecule: CHEMBL1200367
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_778
type: Mechanism
chembl id: CHEMBL_MEC_778
has molecule: CHEMBL1200384
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_199
type: Mechanism
chembl id: CHEMBL_MEC_199
has molecule: CHEMBL1200587
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1694
type: Mechanism
chembl id: CHEMBL_MEC_1694
has molecule: CHEMBL1200589
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_645
type: Mechanism
chembl id: CHEMBL_MEC_645
has molecule: CHEMBL1200963
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_413
type: Mechanism
chembl id: CHEMBL_MEC_413
has molecule: CHEMBL1200492
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_593
type: Mechanism
chembl id: CHEMBL_MEC_593
has molecule: CHEMBL1200492
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_619
type: Mechanism
chembl id: CHEMBL_MEC_619
has molecule: CHEMBL1200492
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_911
type: Mechanism
chembl id: CHEMBL_MEC_911
has molecule: CHEMBL1200492
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_569
type: Mechanism
chembl id: CHEMBL_MEC_569
has molecule: CHEMBL1200601
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_369
type: Mechanism
chembl id: CHEMBL_MEC_369
has molecule: CHEMBL1200601
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_32
type: Mechanism
chembl id: CHEMBL_MEC_32
has molecule: CHEMBL1200604
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_61
type: Mechanism
chembl id: CHEMBL_MEC_61
has molecule: CHEMBL1200826
has target: CHEMBL1786
mechanism description: Inositol-1(or 4)-monophosphatase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1113
type: Mechanism
chembl id: CHEMBL_MEC_1113
has molecule: CHEMBL1200826
has target: CHEMBL2095188
mechanism description: Glycogen synthase kinase-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_281
type: Mechanism
chembl id: CHEMBL_MEC_281
has molecule: CHEMBL1200828
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_609
type: Mechanism
chembl id: CHEMBL_MEC_609
has molecule: CHEMBL1200902
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_213
type: Mechanism
chembl id: CHEMBL_MEC_213
has molecule: CHEMBL1200902
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1262
type: Mechanism
chembl id: CHEMBL_MEC_1262
has molecule: CHEMBL1200983
has target: CHEMBL2095215
has binding site: CHEMBL BS 2658
mechanism description: Ribonucleoside-diphosphate reductase RR1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1557
type: Mechanism
chembl id: CHEMBL_MEC_1557
has molecule: CHEMBL1200983
has target: CHEMBL2363055
mechanism description: Hydroxyapatite sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_2017
type: Mechanism
chembl id: CHEMBL_MEC_2017
has molecule: CHEMBL1200986
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor inverse agonist
mechanism action type: INVERSE AGONIST

CHEMBL_MEC_603
type: Mechanism
chembl id: CHEMBL_MEC_603
has molecule: CHEMBL1200986
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_455
type: Mechanism
chembl id: CHEMBL_MEC_455
has molecule: CHEMBL1201059
has target: CHEMBL1939
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_835
type: Mechanism
chembl id: CHEMBL_MEC_835
has molecule: CHEMBL1201142
has target: CHEMBL2039
mechanism description: Monoamine oxidase B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1013
type: Mechanism
chembl id: CHEMBL_MEC_1013
has molecule: CHEMBL1201146
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_788
type: Mechanism
chembl id: CHEMBL_MEC_788
has molecule: CHEMBL1200968
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_300
type: Mechanism
chembl id: CHEMBL_MEC_300
has molecule: CHEMBL1201740
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_746
type: Mechanism
chembl id: CHEMBL_MEC_746
has molecule: CHEMBL1200541
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_268
type: Mechanism
chembl id: CHEMBL_MEC_268
has molecule: CHEMBL1200760
has target: CHEMBL215
mechanism description: Arachidonate 5-lipoxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_425
type: Mechanism
chembl id: CHEMBL_MEC_425
has molecule: CHEMBL1200760
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_1191
type: Mechanism
chembl id: CHEMBL_MEC_1191
has molecule: CHEMBL1200760
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_648
type: Mechanism
chembl id: CHEMBL_MEC_648
has molecule: CHEMBL1200761
has target: CHEMBL242
mechanism description: Estrogen receptor beta modulator
mechanism action type: MODULATOR

CHEMBL_MEC_228
type: Mechanism
chembl id: CHEMBL_MEC_228
has molecule: CHEMBL1200843
has target: CHEMBL1833
mechanism description: Serotonin 2b (5-HT2b) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_852
type: Mechanism
chembl id: CHEMBL_MEC_852
has molecule: CHEMBL1200843
has target: CHEMBL2056
mechanism description: Dopamine D1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1169
type: Mechanism
chembl id: CHEMBL_MEC_1169
has molecule: CHEMBL1200914
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2000
type: Mechanism
chembl id: CHEMBL_MEC_2000
has molecule: CHEMBL1200996
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_634
type: Mechanism
chembl id: CHEMBL_MEC_634
has molecule: CHEMBL1201155
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_588
type: Mechanism
chembl id: CHEMBL_MEC_588
has molecule: CHEMBL1201155
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2013
type: Mechanism
chembl id: CHEMBL_MEC_2013
has molecule: CHEMBL1201155
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_711
type: Mechanism
chembl id: CHEMBL_MEC_711
has molecule: CHEMBL1201159
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_133
type: Mechanism
chembl id: CHEMBL_MEC_133
has molecule: CHEMBL1200491
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_134
type: Mechanism
chembl id: CHEMBL_MEC_134
has molecule: CHEMBL1200497
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1937
type: Mechanism
chembl id: CHEMBL_MEC_1937
has molecule: CHEMBL1200448
has target: CHEMBL2366048
mechanism description: ATP inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2157
type: Mechanism
chembl id: CHEMBL_MEC_2157
has molecule: CHEMBL1200456
mechanism description: Unknown

CHEMBL_MEC_906
type: Mechanism
chembl id: CHEMBL_MEC_906
has molecule: CHEMBL1200387
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_692
type: Mechanism
chembl id: CHEMBL_MEC_692
has molecule: CHEMBL1200387
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_2135
type: Mechanism
chembl id: CHEMBL_MEC_2135
has molecule: CHEMBL1200391
mechanism description: Unknown

CHEMBL_MEC_765
type: Mechanism
chembl id: CHEMBL_MEC_765
has molecule: CHEMBL389621
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1784
type: Mechanism
chembl id: CHEMBL_MEC_1784
has molecule: CHEMBL1200407
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1870
type: Mechanism
chembl id: CHEMBL_MEC_1870
has molecule: CHEMBL1200410
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_396
type: Mechanism
chembl id: CHEMBL_MEC_396
has molecule: CHEMBL1200710
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2131
type: Mechanism
chembl id: CHEMBL_MEC_2131
has molecule: CHEMBL1200711
mechanism description: Unknown

CHEMBL_MEC_151
type: Mechanism
chembl id: CHEMBL_MEC_151
has molecule: CHEMBL1200967
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1635
type: Mechanism
chembl id: CHEMBL_MEC_1635
has molecule: CHEMBL1200969
has target: CHEMBL2363075
mechanism description: Steroid 5-alpha-reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1690
type: Mechanism
chembl id: CHEMBL_MEC_1690
has molecule: CHEMBL1200971
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1693
type: Mechanism
chembl id: CHEMBL_MEC_1693
has molecule: CHEMBL1201046
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1498
type: Mechanism
chembl id: CHEMBL_MEC_1498
has molecule: CHEMBL1201127
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2358
type: Mechanism
chembl id: CHEMBL_MEC_2358
has molecule: CHEMBL1201130
has target: CHEMBL3391661
mechanism description: Betaine-homocysteine S-methyltransferase substrate
mechanism action type: SUBSTRATE

CHEMBL_MEC_5522
type: Mechanism
chembl id: CHEMBL_MEC_5522
has molecule: CHEMBL1201341
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1230
type: Mechanism
chembl id: CHEMBL_MEC_1230
has molecule: CHEMBL1200338
has target: CHEMBL2095198
has binding site: CHEMBL BS 2655
mechanism description: Sulfonylurea receptor 2, Kir6.2 opener
mechanism action type: OPENER

CHEMBL_MEC_115
type: Mechanism
chembl id: CHEMBL_MEC_115
has molecule: CHEMBL1200343
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_644
type: Mechanism
chembl id: CHEMBL_MEC_644
has molecule: CHEMBL1200896
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_998
type: Mechanism
chembl id: CHEMBL_MEC_998
has molecule: CHEMBL1200901
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1096
type: Mechanism
chembl id: CHEMBL_MEC_1096
has molecule: CHEMBL1201132
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta agonist
mechanism action type: AGONIST

CHEMBL_MEC_1552
type: Mechanism
chembl id: CHEMBL_MEC_1552
has molecule: CHEMBL1200694
has target: CHEMBL2363052
has binding site: CHEMBL BS 2639
mechanism description: Glycine receptor (alpha-1/beta) positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_2050
type: Mechanism
chembl id: CHEMBL_MEC_2050
has molecule: CHEMBL1200694
has target: CHEMBL2321613
mechanism description: Potassium channel subfamily K member 3 opener
mechanism action type: OPENER

CHEMBL_MEC_1621
type: Mechanism
chembl id: CHEMBL_MEC_1621
has molecule: CHEMBL1200694
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_2062
type: Mechanism
chembl id: CHEMBL_MEC_2062
has molecule: CHEMBL1200694
has target: CHEMBL2321615
mechanism description: Potassium channel subfamily K member 2 opener
mechanism action type: OPENER

CHEMBL_MEC_1946
type: Mechanism
chembl id: CHEMBL_MEC_1946
has molecule: CHEMBL1200694
has target: CHEMBL2331042
mechanism description: Potassium channel subfamily K member 18 opener
mechanism action type: OPENER

CHEMBL_MEC_1941
type: Mechanism
chembl id: CHEMBL_MEC_1941
has molecule: CHEMBL1200694
has target: CHEMBL2331041
mechanism description: Potassium channel subfamily K member 10 opener
mechanism action type: OPENER

CHEMBL_MEC_2056
type: Mechanism
chembl id: CHEMBL_MEC_2056
has molecule: CHEMBL1200694
has target: CHEMBL2321614
mechanism description: Potassium channel subfamily K member 9 opener
mechanism action type: OPENER

CHEMBL_MEC_109
type: Mechanism
chembl id: CHEMBL_MEC_109
has molecule: CHEMBL1200697
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_739
type: Mechanism
chembl id: CHEMBL_MEC_739
has molecule: CHEMBL1200933
has target: CHEMBL220
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_315
type: Mechanism
chembl id: CHEMBL_MEC_315
has molecule: CHEMBL1201177
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1363
type: Mechanism
chembl id: CHEMBL_MEC_1363
has molecule: CHEMBL1201177
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_431
type: Mechanism
chembl id: CHEMBL_MEC_431
has molecule: CHEMBL1201745
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_724
type: Mechanism
chembl id: CHEMBL_MEC_724
has molecule: CHEMBL1201163
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1144
type: Mechanism
chembl id: CHEMBL_MEC_1144
has molecule: CHEMBL1200494
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1847
type: Mechanism
chembl id: CHEMBL_MEC_1847
has molecule: CHEMBL1201001
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1345
type: Mechanism
chembl id: CHEMBL_MEC_1345
has molecule: CHEMBL1201160
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1074
type: Mechanism
chembl id: CHEMBL_MEC_1074
has molecule: CHEMBL1201165
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_166
type: Mechanism
chembl id: CHEMBL_MEC_166
has molecule: CHEMBL1200550
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1134
type: Mechanism
chembl id: CHEMBL_MEC_1134
has molecule: CHEMBL1200759
has target: CHEMBL2094125
mechanism description: Phosphodiesterase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_772
type: Mechanism
chembl id: CHEMBL_MEC_772
has molecule: CHEMBL1200762
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_168
type: Mechanism
chembl id: CHEMBL_MEC_168
has molecule: CHEMBL1201759
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_769
type: Mechanism
chembl id: CHEMBL_MEC_769
has molecule: CHEMBL1200495
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1955
type: Mechanism
chembl id: CHEMBL_MEC_1955
has molecule: CHEMBL1200606
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_400
type: Mechanism
chembl id: CHEMBL_MEC_400
has molecule: CHEMBL1200609
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_234
type: Mechanism
chembl id: CHEMBL_MEC_234
has molecule: CHEMBL1200748
has target: CHEMBL1843
mechanism description: DOPA decarboxylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1402
type: Mechanism
chembl id: CHEMBL_MEC_1402
has molecule: CHEMBL1200832
has target: CHEMBL2364679
mechanism description: Squalene monooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_273
type: Mechanism
chembl id: CHEMBL_MEC_273
has molecule: CHEMBL1200906
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_23
type: Mechanism
chembl id: CHEMBL_MEC_23
has molecule: CHEMBL1200906
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_226
type: Mechanism
chembl id: CHEMBL_MEC_226
has molecule: CHEMBL1200987
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_405
type: Mechanism
chembl id: CHEMBL_MEC_405
has molecule: CHEMBL1201066
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_922
type: Mechanism
chembl id: CHEMBL_MEC_922
has molecule: CHEMBL1201066
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1095
type: Mechanism
chembl id: CHEMBL_MEC_1095
has molecule: CHEMBL1201149
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_482
type: Mechanism
chembl id: CHEMBL_MEC_482
has molecule: CHEMBL1200644
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_1808
type: Mechanism
chembl id: CHEMBL_MEC_1808
has molecule: CHEMBL1200394
has target: CHEMBL2364030
mechanism description: Calcium chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_484
type: Mechanism
chembl id: CHEMBL_MEC_484
has molecule: CHEMBL1200373
has target: CHEMBL1952
mechanism description: Thymidylate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_850
type: Mechanism
chembl id: CHEMBL_MEC_850
has molecule: CHEMBL1200373
has target: CHEMBL202
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_963
type: Mechanism
chembl id: CHEMBL_MEC_963
has molecule: CHEMBL1200373
has target: CHEMBL3972
mechanism description: GAR transformylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1355
type: Mechanism
chembl id: CHEMBL_MEC_1355
has molecule: CHEMBL1201731
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_329
type: Mechanism
chembl id: CHEMBL_MEC_329
has molecule: CHEMBL1201731
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_567
type: Mechanism
chembl id: CHEMBL_MEC_567
has molecule: CHEMBL1201003
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_96
type: Mechanism
chembl id: CHEMBL_MEC_96
has molecule: CHEMBL1201003
has target: CHEMBL1805
mechanism description: Serotonin 1f (5-HT1f) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_365
type: Mechanism
chembl id: CHEMBL_MEC_365
has molecule: CHEMBL1201003
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_142
type: Mechanism
chembl id: CHEMBL_MEC_142
has molecule: CHEMBL1201006
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1741
type: Mechanism
chembl id: CHEMBL_MEC_1741
has molecule: CHEMBL1200468
has target: CHEMBL2362988
mechanism description: Acetylcholinesterase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1617
type: Mechanism
chembl id: CHEMBL_MEC_1617
has molecule: CHEMBL1200472
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_402
type: Mechanism
chembl id: CHEMBL_MEC_402
has molecule: CHEMBL1200595
has target: CHEMBL228
mechanism description: Serotonin transporter substrate
mechanism action type: SUBSTRATE

CHEMBL_MEC_1957
type: Mechanism
chembl id: CHEMBL_MEC_1957
has molecule: CHEMBL1200715
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_298
type: Mechanism
chembl id: CHEMBL_MEC_298
has molecule: CHEMBL1200891
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_50
type: Mechanism
chembl id: CHEMBL_MEC_50
has molecule: CHEMBL1200891
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1319
type: Mechanism
chembl id: CHEMBL_MEC_1319
has molecule: CHEMBL1201048
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1332
type: Mechanism
chembl id: CHEMBL_MEC_1332
has molecule: CHEMBL1200412
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1770
type: Mechanism
chembl id: CHEMBL_MEC_1770
has molecule: CHEMBL1200506
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_257
type: Mechanism
chembl id: CHEMBL_MEC_257
has molecule: CHEMBL1200511
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_45
type: Mechanism
chembl id: CHEMBL_MEC_45
has molecule: CHEMBL1200950
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_294
type: Mechanism
chembl id: CHEMBL_MEC_294
has molecule: CHEMBL1200950
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_452
type: Mechanism
chembl id: CHEMBL_MEC_452
has molecule: CHEMBL1201187
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_261
type: Mechanism
chembl id: CHEMBL_MEC_261
has molecule: CHEMBL1200509
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1473
type: Mechanism
chembl id: CHEMBL_MEC_1473
has molecule: CHEMBL1200454
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_787
type: Mechanism
chembl id: CHEMBL_MEC_787
has molecule: CHEMBL1200908
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1195
type: Mechanism
chembl id: CHEMBL_MEC_1195
has molecule: CHEMBL1201124
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_582
type: Mechanism
chembl id: CHEMBL_MEC_582
has molecule: CHEMBL1200798
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_404
type: Mechanism
chembl id: CHEMBL_MEC_404
has molecule: CHEMBL1200798
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_626
type: Mechanism
chembl id: CHEMBL_MEC_626
has molecule: CHEMBL1200798
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_117
type: Mechanism
chembl id: CHEMBL_MEC_117
has molecule: CHEMBL1200659
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2204
type: Mechanism
chembl id: CHEMBL_MEC_2204
has molecule: CHEMBL1200661
mechanism description: Unknown

CHEMBL_MEC_1866
type: Mechanism
chembl id: CHEMBL_MEC_1866
has molecule: CHEMBL1200863
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1199
type: Mechanism
chembl id: CHEMBL_MEC_1199
has molecule: CHEMBL1200864
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2194
type: Mechanism
chembl id: CHEMBL_MEC_2194
has molecule: CHEMBL1200943
mechanism description: Unknown

CHEMBL_MEC_1962
type: Mechanism
chembl id: CHEMBL_MEC_1962
has molecule: CHEMBL1201020
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1163
type: Mechanism
chembl id: CHEMBL_MEC_1163
has molecule: CHEMBL1201103
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1827
type: Mechanism
chembl id: CHEMBL_MEC_1827
has molecule: CHEMBL1201104
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_167
type: Mechanism
chembl id: CHEMBL_MEC_167
has molecule: CHEMBL1201190
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1748
type: Mechanism
chembl id: CHEMBL_MEC_1748
has molecule: CHEMBL1200580
has target: CHEMBL2362993
mechanism description: Dihydropteroate synthase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1316
type: Mechanism
chembl id: CHEMBL_MEC_1316
has molecule: CHEMBL1200585
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2002
type: Mechanism
chembl id: CHEMBL_MEC_2002
has molecule: CHEMBL1200705
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_26
type: Mechanism
chembl id: CHEMBL_MEC_26
has molecule: CHEMBL1200880
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_276
type: Mechanism
chembl id: CHEMBL_MEC_276
has molecule: CHEMBL1200880
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_406
type: Mechanism
chembl id: CHEMBL_MEC_406
has molecule: CHEMBL1200964
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_904
type: Mechanism
chembl id: CHEMBL_MEC_904
has molecule: CHEMBL1200964
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_905
type: Mechanism
chembl id: CHEMBL_MEC_905
has molecule: CHEMBL1200332
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_415
type: Mechanism
chembl id: CHEMBL_MEC_415
has molecule: CHEMBL1200332
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1537
type: Mechanism
chembl id: CHEMBL_MEC_1537
has molecule: CHEMBL1200648
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1806
type: Mechanism
chembl id: CHEMBL_MEC_1806
has molecule: CHEMBL1200656
has target: CHEMBL2364028
mechanism description: Ergosterol sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_786
type: Mechanism
chembl id: CHEMBL_MEC_786
has molecule: CHEMBL1200877
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2160
type: Mechanism
chembl id: CHEMBL_MEC_2160
has molecule: CHEMBL1200887
mechanism description: Unknown

CHEMBL_MEC_1525
type: Mechanism
chembl id: CHEMBL_MEC_1525
has molecule: CHEMBL1201121
has target: CHEMBL2362973
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_655
type: Mechanism
chembl id: CHEMBL_MEC_655
has molecule: CHEMBL1201129
has target: CHEMBL1993
mechanism description: DNA (cytosine-5)-methyltransferase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_653
type: Mechanism
chembl id: CHEMBL_MEC_653
has molecule: CHEMBL1201129
has target: CHEMBL1992
mechanism description: DNA (cytosine-5)-methyltransferase 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1880
type: Mechanism
chembl id: CHEMBL_MEC_1880
has molecule: CHEMBL1201129
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_145
type: Mechanism
chembl id: CHEMBL_MEC_145
has molecule: CHEMBL1200532
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2209
type: Mechanism
chembl id: CHEMBL_MEC_2209
has molecule: CHEMBL1200625
mechanism description: Unknown

CHEMBL_MEC_20
type: Mechanism
chembl id: CHEMBL_MEC_20
has molecule: CHEMBL1200771
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_286
type: Mechanism
chembl id: CHEMBL_MEC_286
has molecule: CHEMBL1200771
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1994
type: Mechanism
chembl id: CHEMBL_MEC_1994
has molecule: CHEMBL1200773
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1470
type: Mechanism
chembl id: CHEMBL_MEC_1470
has molecule: CHEMBL1200850
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1050
type: Mechanism
chembl id: CHEMBL_MEC_1050
has molecule: CHEMBL1201008
has target: CHEMBL1782
mechanism description: Farnesyl diphosphate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_198
type: Mechanism
chembl id: CHEMBL_MEC_198
has molecule: CHEMBL1201087
has target: CHEMBL217
mechanism description: Dopamine D2 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_223
type: Mechanism
chembl id: CHEMBL_MEC_223
has molecule: CHEMBL1200670
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2148
type: Mechanism
chembl id: CHEMBL_MEC_2148
has molecule: CHEMBL1200676
mechanism description: Unknown

CHEMBL_MEC_1631
type: Mechanism
chembl id: CHEMBL_MEC_1631
has molecule: CHEMBL1200789
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1612
type: Mechanism
chembl id: CHEMBL_MEC_1612
has molecule: CHEMBL1200790
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_197
type: Mechanism
chembl id: CHEMBL_MEC_197
has molecule: CHEMBL1200792
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_458
type: Mechanism
chembl id: CHEMBL_MEC_458
has molecule: CHEMBL1200949
has target: CHEMBL1941
mechanism description: Histamine H2 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1567
type: Mechanism
chembl id: CHEMBL_MEC_1567
has molecule: CHEMBL1200952
has target: CHEMBL2363064
mechanism description: Monoamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1958
type: Mechanism
chembl id: CHEMBL_MEC_1958
has molecule: CHEMBL1201022
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1351
type: Mechanism
chembl id: CHEMBL_MEC_1351
has molecule: CHEMBL1201026
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_816
type: Mechanism
chembl id: CHEMBL_MEC_816
has molecule: CHEMBL1200617
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1997
type: Mechanism
chembl id: CHEMBL_MEC_1997
has molecule: CHEMBL1200833
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_781
type: Mechanism
chembl id: CHEMBL_MEC_781
has molecule: CHEMBL1201081
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1170
type: Mechanism
chembl id: CHEMBL_MEC_1170
has molecule: CHEMBL1201091
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_848
type: Mechanism
chembl id: CHEMBL_MEC_848
has molecule: CHEMBL1201746
has target: CHEMBL202
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1105
type: Mechanism
chembl id: CHEMBL_MEC_1105
has molecule: CHEMBL1201748
has target: CHEMBL2095182
has binding site: CHEMBL BS 2629
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_763
type: Mechanism
chembl id: CHEMBL_MEC_763
has molecule: CHEMBL1201749
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_817
type: Mechanism
chembl id: CHEMBL_MEC_817
has molecule: CHEMBL1200844
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2169
type: Mechanism
chembl id: CHEMBL_MEC_2169
has molecule: CHEMBL1200559
mechanism description: pH lowering agent

CHEMBL_MEC_1162
type: Mechanism
chembl id: CHEMBL_MEC_1162
has molecule: CHEMBL1200561
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_710
type: Mechanism
chembl id: CHEMBL_MEC_710
has molecule: CHEMBL1200665
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4873
type: Mechanism
chembl id: CHEMBL_MEC_4873
has molecule: CHEMBL1215661
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_475
type: Mechanism
chembl id: CHEMBL_MEC_475
has molecule: CHEMBL1201414
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_251
type: Mechanism
chembl id: CHEMBL_MEC_251
has molecule: CHEMBL1201419
has target: CHEMBL1854
mechanism description: Luteinizing hormone/Choriogonadotropin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_82
type: Mechanism
chembl id: CHEMBL_MEC_82
has molecule: CHEMBL1201420
has target: CHEMBL1801
mechanism description: Plasminogen activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_1792
type: Mechanism
chembl id: CHEMBL_MEC_1792
has molecule: CHEMBL1201439
has target: CHEMBL2364167
has binding site: CHEMBL BS 2648
mechanism description: Interleukin-2 receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1809
type: Mechanism
chembl id: CHEMBL_MEC_1809
has molecule: CHEMBL1201441
has target: CHEMBL2364031
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2121
type: Mechanism
chembl id: CHEMBL_MEC_2121
has molecule: CHEMBL1201444
mechanism description: Unknown

CHEMBL_MEC_2127
type: Mechanism
chembl id: CHEMBL_MEC_2127
has molecule: CHEMBL1201447
mechanism description: Surfactant agent

CHEMBL_MEC_505
type: Mechanism
chembl id: CHEMBL_MEC_505
has molecule: CHEMBL1201461
has target: CHEMBL1972
mechanism description: Glutamate [NMDA] receptor subunit epsilon 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_332
type: Mechanism
chembl id: CHEMBL_MEC_332
has molecule: CHEMBL1201461
has target: CHEMBL287
mechanism description: Sigma opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1090
type: Mechanism
chembl id: CHEMBL_MEC_1090
has molecule: CHEMBL1201463
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta agonist
mechanism action type: AGONIST

CHEMBL_MEC_252
type: Mechanism
chembl id: CHEMBL_MEC_252
has molecule: CHEMBL1201464
has target: CHEMBL1854
mechanism description: Luteinizing hormone/Choriogonadotropin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2089
type: Mechanism
chembl id: CHEMBL_MEC_2089
has molecule: CHEMBL1201465
has target: CHEMBL2364181
mechanism description: Polypeptides proteolytic enzyme
mechanism action type: PROTEOLYTIC ENZYME

CHEMBL_MEC_1810
type: Mechanism
chembl id: CHEMBL_MEC_1810
has molecule: CHEMBL1201469
has target: CHEMBL2364031
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2090
type: Mechanism
chembl id: CHEMBL_MEC_2090
has molecule: CHEMBL1201482
has target: CHEMBL2364181
mechanism description: Polypeptides hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_1950
type: Mechanism
chembl id: CHEMBL_MEC_1950
has molecule: CHEMBL1201486
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2091
type: Mechanism
chembl id: CHEMBL_MEC_2091
has molecule: CHEMBL1201487
has target: CHEMBL2364182
mechanism description: Sucrose hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_756
type: Mechanism
chembl id: CHEMBL_MEC_756
has molecule: CHEMBL1201490
has target: CHEMBL2032
mechanism description: Growth hormone-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2093
type: Mechanism
chembl id: CHEMBL_MEC_2093
has molecule: CHEMBL1201492
has target: CHEMBL2364184
mechanism description: Phosphate sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_559
type: Mechanism
chembl id: CHEMBL_MEC_559
has molecule: CHEMBL1201496
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_550
type: Mechanism
chembl id: CHEMBL_MEC_550
has molecule: CHEMBL1201497
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1843
type: Mechanism
chembl id: CHEMBL_MEC_1843
has molecule: CHEMBL1201506
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_233
type: Mechanism
chembl id: CHEMBL_MEC_233
has molecule: CHEMBL1201506
has target: CHEMBL1842
mechanism description: Myeloid cell surface antigen CD33 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_2122
type: Mechanism
chembl id: CHEMBL_MEC_2122
has molecule: CHEMBL1201507
mechanism description: Unknown

CHEMBL_MEC_2095
type: Mechanism
chembl id: CHEMBL_MEC_2095
has molecule: CHEMBL1201512
has target: CHEMBL2364186
mechanism description: Major intermediate early region 2 mRNA antisense inhibitor
mechanism action type: ANTISENSE INHIBITOR

CHEMBL_MEC_480
type: Mechanism
chembl id: CHEMBL_MEC_480
has molecule: CHEMBL1201513
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_514
type: Mechanism
chembl id: CHEMBL_MEC_514
has molecule: CHEMBL1201515
has target: CHEMBL1976
mechanism description: Growth hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_490
type: Mechanism
chembl id: CHEMBL_MEC_490
has molecule: CHEMBL1201533
has target: CHEMBL1963
mechanism description: Thyroid stimulating hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_478
type: Mechanism
chembl id: CHEMBL_MEC_478
has molecule: CHEMBL1201534
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_1043
type: Mechanism
chembl id: CHEMBL_MEC_1043
has molecule: CHEMBL1201536
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_551
type: Mechanism
chembl id: CHEMBL_MEC_551
has molecule: CHEMBL1201539
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_531
type: Mechanism
chembl id: CHEMBL_MEC_531
has molecule: CHEMBL1201540
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_554
type: Mechanism
chembl id: CHEMBL_MEC_554
has molecule: CHEMBL1201541
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_536
type: Mechanism
chembl id: CHEMBL_MEC_536
has molecule: CHEMBL1201543
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_557
type: Mechanism
chembl id: CHEMBL_MEC_557
has molecule: CHEMBL1201546
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2125
type: Mechanism
chembl id: CHEMBL_MEC_2125
has molecule: CHEMBL1201548
mechanism description: Surfactant agent

CHEMBL_MEC_69
type: Mechanism
chembl id: CHEMBL_MEC_69
has molecule: CHEMBL1201549
has target: CHEMBL1793
mechanism description: Parathyroid hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1636
type: Mechanism
chembl id: CHEMBL_MEC_1636
has molecule: CHEMBL1201761
has target: CHEMBL2363076
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1897
type: Mechanism
chembl id: CHEMBL_MEC_1897
has molecule: CHEMBL1201761
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1799
type: Mechanism
chembl id: CHEMBL_MEC_1799
has molecule: CHEMBL1201560
has target: CHEMBL2364170
mechanism description: Interferon alpha/beta receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1803
type: Mechanism
chembl id: CHEMBL_MEC_1803
has molecule: CHEMBL1201564
has target: CHEMBL2364171
mechanism description: Interferon gamma receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_669
type: Mechanism
chembl id: CHEMBL_MEC_669
has molecule: CHEMBL1201567
has target: CHEMBL1996
mechanism description: Granulocyte colony stimulating factor receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1418
type: Mechanism
chembl id: CHEMBL_MEC_1418
has molecule: CHEMBL1201569
has target: CHEMBL2364160
mechanism description: Vesicle-associated membrane protein 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_838
type: Mechanism
chembl id: CHEMBL_MEC_838
has molecule: CHEMBL1201571
has target: CHEMBL2040
mechanism description: T-cell surface antigen CD2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1385
type: Mechanism
chembl id: CHEMBL_MEC_1385
has molecule: CHEMBL1201573
has target: CHEMBL2050
mechanism description: Interleukin 11 receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_2042
type: Mechanism
chembl id: CHEMBL_MEC_2042
has molecule: CHEMBL1201575
has target: CHEMBL2364172
has binding site: CHEMBL BS 2644
mechanism description: Integrin alpha-L/beta-2 (LFA-1) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_182
type: Mechanism
chembl id: CHEMBL_MEC_182
has molecule: CHEMBL1201580
has target: CHEMBL1825
mechanism description: TNF-alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_58
type: Mechanism
chembl id: CHEMBL_MEC_58
has molecule: CHEMBL1201583
has target: CHEMBL1783
mechanism description: Vascular endothelial growth factor A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1294
type: Mechanism
chembl id: CHEMBL_MEC_1294
has molecule: CHEMBL1201584
has target: CHEMBL1907598
has binding site: CHEMBL BS 2645
mechanism description: Integrin alpha-V/beta-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1077
type: Mechanism
chembl id: CHEMBL_MEC_1077
has molecule: CHEMBL1201584
has target: CHEMBL2093869
has binding site: CHEMBL BS 2643
mechanism description: Integrin alpha-IIb/beta-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_127
type: Mechanism
chembl id: CHEMBL_MEC_127
has molecule: CHEMBL1201585
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1423
type: Mechanism
chembl id: CHEMBL_MEC_1423
has molecule: CHEMBL1201586
has target: CHEMBL2364165
mechanism description: Fusion glycoprotein F0 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1370
type: Mechanism
chembl id: CHEMBL_MEC_1370
has molecule: CHEMBL1201587
has target: CHEMBL1912
mechanism description: CAMPATH-1 antigen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1372
type: Mechanism
chembl id: CHEMBL_MEC_1372
has molecule: CHEMBL1201782
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1818
type: Mechanism
chembl id: CHEMBL_MEC_1818
has molecule: CHEMBL1200558
has target: CHEMBL2364036
mechanism description: C55-isoprenyl pyrophosphate inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1148
type: Mechanism
chembl id: CHEMBL_MEC_1148
has molecule: CHEMBL1200560
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_658
type: Mechanism
chembl id: CHEMBL_MEC_658
has molecule: CHEMBL1201010
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1680
type: Mechanism
chembl id: CHEMBL_MEC_1680
has molecule: CHEMBL1201018
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1703
type: Mechanism
chembl id: CHEMBL_MEC_1703
has molecule: CHEMBL1200672
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_224
type: Mechanism
chembl id: CHEMBL_MEC_224
has molecule: CHEMBL1200692
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1591
type: Mechanism
chembl id: CHEMBL_MEC_1591
has molecule: CHEMBL1200703
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_779
type: Mechanism
chembl id: CHEMBL_MEC_779
has molecule: CHEMBL1200538
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_633
type: Mechanism
chembl id: CHEMBL_MEC_633
has molecule: CHEMBL1200636
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_580
type: Mechanism
chembl id: CHEMBL_MEC_580
has molecule: CHEMBL1200636
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_357
type: Mechanism
chembl id: CHEMBL_MEC_357
has molecule: CHEMBL1200776
has target: CHEMBL1878
mechanism description: Calcium sensing receptor positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1682
type: Mechanism
chembl id: CHEMBL_MEC_1682
has molecule: CHEMBL1200855
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2195
type: Mechanism
chembl id: CHEMBL_MEC_2195
has molecule: CHEMBL1201787
mechanism description: Unknown

CHEMBL_MEC_1020
type: Mechanism
chembl id: CHEMBL_MEC_1020
has molecule: CHEMBL1200934
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_106
type: Mechanism
chembl id: CHEMBL_MEC_106
has molecule: CHEMBL1201011
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_819
type: Mechanism
chembl id: CHEMBL_MEC_819
has molecule: CHEMBL1201012
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_175
type: Mechanism
chembl id: CHEMBL_MEC_175
has molecule: CHEMBL1201089
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2219
type: Mechanism
chembl id: CHEMBL_MEC_2219
has molecule: CHEMBL1201093
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2163
type: Mechanism
chembl id: CHEMBL_MEC_2163
has molecule: CHEMBL1201175
mechanism description: Unknown

CHEMBL_MEC_501
type: Mechanism
chembl id: CHEMBL_MEC_501
has molecule: CHEMBL1200564
has target: CHEMBL240
mechanism description: HERG blocker
mechanism action type: BLOCKER

CHEMBL_MEC_980
type: Mechanism
chembl id: CHEMBL_MEC_980
has molecule: CHEMBL1200567
has target: CHEMBL4588
mechanism description: Matrix metalloproteinase 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_968
type: Mechanism
chembl id: CHEMBL_MEC_968
has molecule: CHEMBL1200567
has target: CHEMBL4073
mechanism description: Matrix metalloproteinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_988
type: Mechanism
chembl id: CHEMBL_MEC_988
has molecule: CHEMBL1200567
has target: CHEMBL332
mechanism description: Matrix metalloproteinase-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_983
type: Mechanism
chembl id: CHEMBL_MEC_983
has molecule: CHEMBL1200567
has target: CHEMBL280
mechanism description: Matrix metalloproteinase 13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1305
type: Mechanism
chembl id: CHEMBL_MEC_1305
has molecule: CHEMBL1200682
has target: CHEMBL2111463
mechanism description: GABA-B receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_149
type: Mechanism
chembl id: CHEMBL_MEC_149
has molecule: CHEMBL1200795
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1846
type: Mechanism
chembl id: CHEMBL_MEC_1846
has molecule: CHEMBL1200796
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1236
type: Mechanism
chembl id: CHEMBL_MEC_1236
has molecule: CHEMBL1200873
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1248
type: Mechanism
chembl id: CHEMBL_MEC_1248
has molecule: CHEMBL1200874
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1225
type: Mechanism
chembl id: CHEMBL_MEC_1225
has molecule: CHEMBL1200955
has target: CHEMBL2111369
mechanism description: Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2159
type: Mechanism
chembl id: CHEMBL_MEC_2159
has molecule: CHEMBL1201799
mechanism description: Unknown

CHEMBL_MEC_230
type: Mechanism
chembl id: CHEMBL_MEC_230
has molecule: CHEMBL1201589
has target: CHEMBL1834
mechanism description: Ig epsilon chain C region inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_84
type: Mechanism
chembl id: CHEMBL_MEC_84
has molecule: CHEMBL1201593
has target: CHEMBL1801
mechanism description: Plasminogen activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_1675
type: Mechanism
chembl id: CHEMBL_MEC_1675
has molecule: CHEMBL1201594
has target: CHEMBL2364183
mechanism description: Uric acid oxidative enzyme
mechanism action type: OXIDATIVE ENZYME

CHEMBL_MEC_2119
type: Mechanism
chembl id: CHEMBL_MEC_2119
has molecule: CHEMBL1201603
mechanism description: Unknown

CHEMBL_MEC_1790
type: Mechanism
chembl id: CHEMBL_MEC_1790
has molecule: CHEMBL1201605
has target: CHEMBL2364167
has binding site: CHEMBL BS 2648
mechanism description: Interleukin-2 receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1295
type: Mechanism
chembl id: CHEMBL_MEC_1295
has molecule: CHEMBL1201607
has target: CHEMBL1907599
has binding site: CHEMBL BS 2641
mechanism description: Integrin alpha-4/beta-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1112
type: Mechanism
chembl id: CHEMBL_MEC_1112
has molecule: CHEMBL1201607
has target: CHEMBL2095184
has binding site: CHEMBL BS 2642
mechanism description: Integrin alpha-4/beta-7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_493
type: Mechanism
chembl id: CHEMBL_MEC_493
has molecule: CHEMBL1201609
has target: CHEMBL1965
mechanism description: Melanocortin receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_545
type: Mechanism
chembl id: CHEMBL_MEC_545
has molecule: CHEMBL1201611
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_548
type: Mechanism
chembl id: CHEMBL_MEC_548
has molecule: CHEMBL1201613
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_83
type: Mechanism
chembl id: CHEMBL_MEC_83
has molecule: CHEMBL1201619
has target: CHEMBL1801
mechanism description: Plasminogen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_674
type: Mechanism
chembl id: CHEMBL_MEC_674
has molecule: CHEMBL1201619
has target: CHEMBL2000
mechanism description: Plasma kallikrein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_513
type: Mechanism
chembl id: CHEMBL_MEC_513
has molecule: CHEMBL1201621
has target: CHEMBL1976
mechanism description: Growth hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2116
type: Mechanism
chembl id: CHEMBL_MEC_2116
has molecule: CHEMBL1201624
mechanism description: Surfactant agent

CHEMBL_MEC_2075
type: Mechanism
chembl id: CHEMBL_MEC_2075
has molecule: CHEMBL1201625
has target: CHEMBL2364175
mechanism description: Bile acids sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_541
type: Mechanism
chembl id: CHEMBL_MEC_541
has molecule: CHEMBL1201628
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_532
type: Mechanism
chembl id: CHEMBL_MEC_532
has molecule: CHEMBL1201629
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_542
type: Mechanism
chembl id: CHEMBL_MEC_542
has molecule: CHEMBL1201630
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_546
type: Mechanism
chembl id: CHEMBL_MEC_546
has molecule: CHEMBL1201634
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_540
type: Mechanism
chembl id: CHEMBL_MEC_540
has molecule: CHEMBL1201635
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2040
type: Mechanism
chembl id: CHEMBL_MEC_2040
has molecule: CHEMBL1201637
has target: CHEMBL2364711
mechanism description: Fatty acids hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_544
type: Mechanism
chembl id: CHEMBL_MEC_544
has molecule: CHEMBL1201638
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_534
type: Mechanism
chembl id: CHEMBL_MEC_534
has molecule: CHEMBL1201639
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_552
type: Mechanism
chembl id: CHEMBL_MEC_552
has molecule: CHEMBL1201640
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_549
type: Mechanism
chembl id: CHEMBL_MEC_549
has molecule: CHEMBL1201642
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_555
type: Mechanism
chembl id: CHEMBL_MEC_555
has molecule: CHEMBL1201643
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_533
type: Mechanism
chembl id: CHEMBL_MEC_533
has molecule: CHEMBL1201644
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2086
type: Mechanism
chembl id: CHEMBL_MEC_2086
has molecule: CHEMBL1201648
has target: CHEMBL2364180
mechanism description: Starch hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_1070
type: Mechanism
chembl id: CHEMBL_MEC_1070
has molecule: CHEMBL1201649
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2113
type: Mechanism
chembl id: CHEMBL_MEC_2113
has molecule: CHEMBL1201650
mechanism description: Iodine storage agent

CHEMBL_MEC_2041
type: Mechanism
chembl id: CHEMBL_MEC_2041
has molecule: CHEMBL1201651
has target: CHEMBL2364712
mechanism description: Heparin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_553
type: Mechanism
chembl id: CHEMBL_MEC_553
has molecule: CHEMBL1201655
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2118
type: Mechanism
chembl id: CHEMBL_MEC_2118
has molecule: CHEMBL1201658
mechanism description: Unknown

CHEMBL_MEC_73
type: Mechanism
chembl id: CHEMBL_MEC_73
has molecule: CHEMBL1201662
has target: CHEMBL204
mechanism description: Thrombin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_560
type: Mechanism
chembl id: CHEMBL_MEC_560
has molecule: CHEMBL1201664
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_75
type: Mechanism
chembl id: CHEMBL_MEC_75
has molecule: CHEMBL1201666
has target: CHEMBL204
mechanism description: Thrombin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_749
type: Mechanism
chembl id: CHEMBL_MEC_749
has molecule: CHEMBL1201692
has target: CHEMBL2024
mechanism description: Follicle stimulating hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_751
type: Mechanism
chembl id: CHEMBL_MEC_751
has molecule: CHEMBL1201692
has target: CHEMBL2024
mechanism description: Follicle stimulating hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_488
type: Mechanism
chembl id: CHEMBL_MEC_488
has molecule: CHEMBL1201716
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2114
type: Mechanism
chembl id: CHEMBL_MEC_2114
has molecule: CHEMBL1201723
mechanism description: Unknown

CHEMBL_MEC_660
type: Mechanism
chembl id: CHEMBL_MEC_660
has molecule: CHEMBL1200592
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1073
type: Mechanism
chembl id: CHEMBL_MEC_1073
has molecule: CHEMBL1200598
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1174
type: Mechanism
chembl id: CHEMBL_MEC_1174
has molecule: CHEMBL1200806
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1208
type: Mechanism
chembl id: CHEMBL_MEC_1208
has molecule: CHEMBL571
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_901
type: Mechanism
chembl id: CHEMBL_MEC_901
has molecule: CHEMBL1200328
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_409
type: Mechanism
chembl id: CHEMBL_MEC_409
has molecule: CHEMBL1200328
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2368
type: Mechanism
chembl id: CHEMBL_MEC_2368
has molecule: CHEMBL1200330
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_43
type: Mechanism
chembl id: CHEMBL_MEC_43
has molecule: CHEMBL1200330
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1529
type: Mechanism
chembl id: CHEMBL_MEC_1529
has molecule: CHEMBL1200641
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_192
type: Mechanism
chembl id: CHEMBL_MEC_192
has molecule: CHEMBL1200856
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1826
type: Mechanism
chembl id: CHEMBL_MEC_1826
has molecule: CHEMBL1200869
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1227
type: Mechanism
chembl id: CHEMBL_MEC_1227
has molecule: CHEMBL1200875
has target: CHEMBL2111411
mechanism description: Phosphodiesterase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1572
type: Mechanism
chembl id: CHEMBL_MEC_1572
has molecule: CHEMBL1200875
has target: CHEMBL2363067
mechanism description: Phosphodiesterase 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1065
type: Mechanism
chembl id: CHEMBL_MEC_1065
has molecule: CHEMBL1200875
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_65
type: Mechanism
chembl id: CHEMBL_MEC_65
has molecule: CHEMBL1201108
has target: CHEMBL1790
mechanism description: Vasopressin V2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_362
type: Mechanism
chembl id: CHEMBL_MEC_362
has molecule: CHEMBL1201108
has target: CHEMBL1889
mechanism description: Vasopressin V1a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2078
type: Mechanism
chembl id: CHEMBL_MEC_2078
has molecule: CHEMBL1201865
has target: CHEMBL2364176
mechanism description: Glucocerebroside hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_4319
type: Mechanism
chembl id: CHEMBL_MEC_4319
has molecule: CHEMBL1230607
has target: CHEMBL3559691
mechanism description: Cyclin-dependent kinase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4726
type: Mechanism
chembl id: CHEMBL_MEC_4726
has molecule: CHEMBL1230609
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4727
type: Mechanism
chembl id: CHEMBL_MEC_4727
has molecule: CHEMBL1230609
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4730
type: Mechanism
chembl id: CHEMBL_MEC_4730
has molecule: CHEMBL1230609
has target: CHEMBL4128
mechanism description: Tyrosine-protein kinase TIE-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4731
type: Mechanism
chembl id: CHEMBL_MEC_4731
has molecule: CHEMBL1230609
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4728
type: Mechanism
chembl id: CHEMBL_MEC_4728
has molecule: CHEMBL1230609
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4729
type: Mechanism
chembl id: CHEMBL_MEC_4729
has molecule: CHEMBL1230609
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_937
type: Mechanism
chembl id: CHEMBL_MEC_937
has molecule: CHEMBL1201775
has target: CHEMBL3076
mechanism description: Phenylalanine-4-hydroxylase activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_2201
type: Mechanism
chembl id: CHEMBL_MEC_2201
has molecule: CHEMBL975
mechanism description: Unknown

CHEMBL_MEC_995
type: Mechanism
chembl id: CHEMBL_MEC_995
has molecule: CHEMBL1229517
has target: CHEMBL5145
mechanism description: Serine/threonine-protein kinase B-raf inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5875
type: Mechanism
chembl id: CHEMBL_MEC_5875
has molecule: CHEMBL468
has target: CHEMBL3833061
mechanism description: CRL4(CRBN) E3 ubiquitin ligase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1884
type: Mechanism
chembl id: CHEMBL_MEC_1884
has molecule: CHEMBL1200847
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1896
type: Mechanism
chembl id: CHEMBL_MEC_1896
has molecule: CHEMBL1200847
has target: CHEMBL2311222
mechanism description: RNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1691
type: Mechanism
chembl id: CHEMBL_MEC_1691
has molecule: CHEMBL1200965
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2076
type: Mechanism
chembl id: CHEMBL_MEC_2076
has molecule: CHEMBL1201473
has target: CHEMBL2364175
mechanism description: Bile acids sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_1521
type: Mechanism
chembl id: CHEMBL_MEC_1521
has molecule: CHEMBL1201576
has target: CHEMBL2058
mechanism description: B-lymphocyte antigen CD20 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2126
type: Mechanism
chembl id: CHEMBL_MEC_2126
has molecule: CHEMBL1201622
mechanism description: Surfactant agent

CHEMBL_MEC_131
type: Mechanism
chembl id: CHEMBL_MEC_131
has molecule: CHEMBL1201659
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_179
type: Mechanism
chembl id: CHEMBL_MEC_179
has molecule: CHEMBL1200948
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_628
type: Mechanism
chembl id: CHEMBL_MEC_628
has molecule: CHEMBL1200948
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_215
type: Mechanism
chembl id: CHEMBL_MEC_215
has molecule: CHEMBL1200948
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_611
type: Mechanism
chembl id: CHEMBL_MEC_611
has molecule: CHEMBL1200948
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1158
type: Mechanism
chembl id: CHEMBL_MEC_1158
has molecule: CHEMBL1200948
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_921
type: Mechanism
chembl id: CHEMBL_MEC_921
has molecule: CHEMBL1200948
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_800
type: Mechanism
chembl id: CHEMBL_MEC_800
has molecule: CHEMBL1201014
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1424
type: Mechanism
chembl id: CHEMBL_MEC_1424
has molecule: CHEMBL1201041
has target: CHEMBL2363020
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1849
type: Mechanism
chembl id: CHEMBL_MEC_1849
has molecule: CHEMBL1201112
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1713
type: Mechanism
chembl id: CHEMBL_MEC_1713
has molecule: CHEMBL1541
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_923
type: Mechanism
chembl id: CHEMBL_MEC_923
has molecule: CHEMBL18442
has target: CHEMBL2107
mechanism description: C-X-C chemokine receptor type 4 partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_71
type: Mechanism
chembl id: CHEMBL_MEC_71
has molecule: CHEMBL603
has target: CHEMBL1798
mechanism description: Cysteinyl leukotriene receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1286
type: Mechanism
chembl id: CHEMBL_MEC_1286
has molecule: CHEMBL636
has target: CHEMBL2095233
mechanism description: Cholinesterases; ACHE & BCHE inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_525
type: Mechanism
chembl id: CHEMBL_MEC_525
has molecule: CHEMBL1200374
has target: CHEMBL1978
mechanism description: Cytochrome P450 19A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_135
type: Mechanism
chembl id: CHEMBL_MEC_135
has molecule: CHEMBL1200618
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1166
type: Mechanism
chembl id: CHEMBL_MEC_1166
has molecule: CHEMBL1200461
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_2154
type: Mechanism
chembl id: CHEMBL_MEC_2154
has molecule: CHEMBL1201050
mechanism description: Unknown

CHEMBL_MEC_874
type: Mechanism
chembl id: CHEMBL_MEC_874
has molecule: CHEMBL1201483
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_2080
type: Mechanism
chembl id: CHEMBL_MEC_2080
has molecule: CHEMBL1201632
has target: CHEMBL2364176
mechanism description: Glucocerebroside hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_822
type: Mechanism
chembl id: CHEMBL_MEC_822
has molecule: CHEMBL853
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1497
type: Mechanism
chembl id: CHEMBL_MEC_1497
has molecule: CHEMBL222559
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1502
type: Mechanism
chembl id: CHEMBL_MEC_1502
has molecule: CHEMBL1717
has target: CHEMBL2001
mechanism description: Purinergic receptor P2Y12 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_910
type: Mechanism
chembl id: CHEMBL_MEC_910
has molecule: CHEMBL1722
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_699
type: Mechanism
chembl id: CHEMBL_MEC_699
has molecule: CHEMBL1722
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1069
type: Mechanism
chembl id: CHEMBL_MEC_1069
has molecule: CHEMBL1201466
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1522
type: Mechanism
chembl id: CHEMBL_MEC_1522
has molecule: CHEMBL1201836
has target: CHEMBL2058
mechanism description: B-lymphocyte antigen CD20 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5617
type: Mechanism
chembl id: CHEMBL_MEC_5617
has molecule: CHEMBL218650
has target: CHEMBL2111188
mechanism description: Mycobacterium tuberculosis H37Rv inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4698
type: Mechanism
chembl id: CHEMBL_MEC_4698
has molecule: CHEMBL1230165
has target: CHEMBL3629
mechanism description: Casein kinase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4974
type: Mechanism
chembl id: CHEMBL_MEC_4974
has molecule: CHEMBL1198855
has target: CHEMBL1878
mechanism description: Calcium sensing receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2138
type: Mechanism
chembl id: CHEMBL_MEC_2138
has molecule: CHEMBL1200582
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1190
type: Mechanism
chembl id: CHEMBL_MEC_1190
has molecule: CHEMBL1200584
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2072
type: Mechanism
chembl id: CHEMBL_MEC_2072
has molecule: CHEMBL1200780
has target: CHEMBL2364022
has binding site: CHEMBL BS 2624
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_47
type: Mechanism
chembl id: CHEMBL_MEC_47
has molecule: CHEMBL1201024
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_295
type: Mechanism
chembl id: CHEMBL_MEC_295
has molecule: CHEMBL1201024
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_282
type: Mechanism
chembl id: CHEMBL_MEC_282
has molecule: CHEMBL1201035
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2179
type: Mechanism
chembl id: CHEMBL_MEC_2179
has molecule: CHEMBL1201795
mechanism description: Unknown

CHEMBL_MEC_1765
type: Mechanism
chembl id: CHEMBL_MEC_1765
has molecule: CHEMBL1200474
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1638
type: Mechanism
chembl id: CHEMBL_MEC_1638
has molecule: CHEMBL1200735
has target: CHEMBL2363076
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1906
type: Mechanism
chembl id: CHEMBL_MEC_1906
has molecule: CHEMBL1200735
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2367
type: Mechanism
chembl id: CHEMBL_MEC_2367
has molecule: CHEMBL1201729
has target: CHEMBL1250417
mechanism description: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2366
type: Mechanism
chembl id: CHEMBL_MEC_2366
has molecule: CHEMBL1201729
has target: CHEMBL1914276
mechanism description: Inward rectifier potassium channel 2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1963
type: Mechanism
chembl id: CHEMBL_MEC_1963
has molecule: CHEMBL1201729
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1273
type: Mechanism
chembl id: CHEMBL_MEC_1273
has molecule: CHEMBL1201729
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1279
type: Mechanism
chembl id: CHEMBL_MEC_1279
has molecule: CHEMBL1200326
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1815
type: Mechanism
chembl id: CHEMBL_MEC_1815
has molecule: CHEMBL1200626
has target: CHEMBL2364032
mechanism description: Cell outer membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1547
type: Mechanism
chembl id: CHEMBL_MEC_1547
has molecule: CHEMBL1200633
has target: CHEMBL2363050
mechanism description: Glutamate-gated chloride channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_1548
type: Mechanism
chembl id: CHEMBL_MEC_1548
has molecule: CHEMBL1200633
has target: CHEMBL2363051
mechanism description: Glutamate-gated chloride channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_2139
type: Mechanism
chembl id: CHEMBL_MEC_2139
has molecule: CHEMBL1200838
mechanism description: Antifoaming agent

CHEMBL_MEC_1685
type: Mechanism
chembl id: CHEMBL_MEC_1685
has molecule: CHEMBL1200852
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2181
type: Mechanism
chembl id: CHEMBL_MEC_2181
has molecule: CHEMBL1200354
mechanism description: Unknown

CHEMBL_MEC_607
type: Mechanism
chembl id: CHEMBL_MEC_607
has molecule: CHEMBL1200916
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2018
type: Mechanism
chembl id: CHEMBL_MEC_2018
has molecule: CHEMBL1200916
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_625
type: Mechanism
chembl id: CHEMBL_MEC_625
has molecule: CHEMBL1200916
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1217
type: Mechanism
chembl id: CHEMBL_MEC_1217
has molecule: CHEMBL1200578
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1064
type: Mechanism
chembl id: CHEMBL_MEC_1064
has molecule: CHEMBL1200578
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1133
type: Mechanism
chembl id: CHEMBL_MEC_1133
has molecule: CHEMBL1200578
has target: CHEMBL2094125
mechanism description: Phosphodiesterase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1673
type: Mechanism
chembl id: CHEMBL_MEC_1673
has molecule: CHEMBL1200698
has target: CHEMBL2366037
mechanism description: Radioactive metals chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_643
type: Mechanism
chembl id: CHEMBL_MEC_643
has molecule: CHEMBL1200799
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1189
type: Mechanism
chembl id: CHEMBL_MEC_1189
has molecule: CHEMBL1200804
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2049
type: Mechanism
chembl id: CHEMBL_MEC_2049
has molecule: CHEMBL1200876
has target: CHEMBL2321613
mechanism description: Potassium channel subfamily K member 3 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2055
type: Mechanism
chembl id: CHEMBL_MEC_2055
has molecule: CHEMBL1200876
has target: CHEMBL2321614
mechanism description: Potassium channel subfamily K member 9 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_806
type: Mechanism
chembl id: CHEMBL_MEC_806
has molecule: CHEMBL1200878
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_444
type: Mechanism
chembl id: CHEMBL_MEC_444
has molecule: CHEMBL1200879
has target: CHEMBL1930
mechanism description: Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1315
type: Mechanism
chembl id: CHEMBL_MEC_1315
has molecule: CHEMBL1201037
has target: CHEMBL1869
mechanism description: Ornithine decarboxylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1367
type: Mechanism
chembl id: CHEMBL_MEC_1367
has molecule: CHEMBL1201115
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_312
type: Mechanism
chembl id: CHEMBL_MEC_312
has molecule: CHEMBL1201115
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1692
type: Mechanism
chembl id: CHEMBL_MEC_1692
has molecule: CHEMBL1201118
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1985
type: Mechanism
chembl id: CHEMBL_MEC_1985
has molecule: CHEMBL1201754
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_723
type: Mechanism
chembl id: CHEMBL_MEC_723
has molecule: CHEMBL1201770
has target: CHEMBL233
mechanism description: Mu opioid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_657
type: Mechanism
chembl id: CHEMBL_MEC_657
has molecule: CHEMBL1200542
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1309
type: Mechanism
chembl id: CHEMBL_MEC_1309
has molecule: CHEMBL1200543
has target: CHEMBL237
mechanism description: Kappa opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_730
type: Mechanism
chembl id: CHEMBL_MEC_730
has molecule: CHEMBL1200543
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1903
type: Mechanism
chembl id: CHEMBL_MEC_1903
has molecule: CHEMBL1200779
has target: CHEMBL2311224
mechanism description: Bacterial DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1641
type: Mechanism
chembl id: CHEMBL_MEC_1641
has molecule: CHEMBL1200779
has target: CHEMBL2363076
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1761
type: Mechanism
chembl id: CHEMBL_MEC_1761
has molecule: CHEMBL1200937
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_427
type: Mechanism
chembl id: CHEMBL_MEC_427
has molecule: CHEMBL1201013
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_271
type: Mechanism
chembl id: CHEMBL_MEC_271
has molecule: CHEMBL1201013
has target: CHEMBL215
mechanism description: Arachidonate 5-lipoxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1197
type: Mechanism
chembl id: CHEMBL_MEC_1197
has molecule: CHEMBL1201013
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2066
type: Mechanism
chembl id: CHEMBL_MEC_2066
has molecule: CHEMBL1201097
has target: CHEMBL2363853
has binding site: CHEMBL BS 2622
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1093
type: Mechanism
chembl id: CHEMBL_MEC_1093
has molecule: CHEMBL1201099
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta agonist
mechanism action type: AGONIST

CHEMBL_MEC_1175
type: Mechanism
chembl id: CHEMBL_MEC_1175
has molecule: CHEMBL1201180
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_647
type: Mechanism
chembl id: CHEMBL_MEC_647
has molecule: CHEMBL1200721
has target: CHEMBL242
mechanism description: Estrogen receptor beta
mechanism action type: MODULATOR

CHEMBL_MEC_2225
type: Mechanism
chembl id: CHEMBL_MEC_2225
has molecule: CHEMBL1200721
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_808
type: Mechanism
chembl id: CHEMBL_MEC_808
has molecule: CHEMBL1201148
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1842
type: Mechanism
chembl id: CHEMBL_MEC_1842
has molecule: CHEMBL1201459
has target: CHEMBL2311221
mechanism description: DNA hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_535
type: Mechanism
chembl id: CHEMBL_MEC_535
has molecule: CHEMBL1201542
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1023
type: Mechanism
chembl id: CHEMBL_MEC_1023
has molecule: CHEMBL260538
has target: CHEMBL208
mechanism description: Progesterone receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4379
type: Mechanism
chembl id: CHEMBL_MEC_4379
has molecule: CHEMBL1236107
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_453
type: Mechanism
chembl id: CHEMBL_MEC_453
has molecule: CHEMBL36
has target: CHEMBL1939
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2152
type: Mechanism
chembl id: CHEMBL_MEC_2152
has molecule: CHEMBL1231723
mechanism description: Unknown

CHEMBL_MEC_4641
type: Mechanism
chembl id: CHEMBL_MEC_4641
has molecule: CHEMBL1231124
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4596
type: Mechanism
chembl id: CHEMBL_MEC_4596
has molecule: CHEMBL1236924
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4223
type: Mechanism
chembl id: CHEMBL_MEC_4223
has molecule: CHEMBL1236962
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4222
type: Mechanism
chembl id: CHEMBL_MEC_4222
has molecule: CHEMBL1236962
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5153
type: Mechanism
chembl id: CHEMBL_MEC_5153
has molecule: CHEMBL127071
has target: CHEMBL3038461
mechanism description: Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_5154
type: Mechanism
chembl id: CHEMBL_MEC_5154
has molecule: CHEMBL127071
has target: CHEMBL2109237
mechanism description: Neuronal acetylcholine receptor; alpha6/beta2 partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_2155
type: Mechanism
chembl id: CHEMBL_MEC_2155
has molecule: CHEMBL1201864
mechanism description: Unknown

CHEMBL_MEC_5597
type: Mechanism
chembl id: CHEMBL_MEC_5597
has molecule: CHEMBL48361
has target: CHEMBL204
mechanism description: Thrombin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1975
type: Mechanism
chembl id: CHEMBL_MEC_1975
has molecule: CHEMBL58323
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_888
type: Mechanism
chembl id: CHEMBL_MEC_888
has molecule: CHEMBL1201735
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_689
type: Mechanism
chembl id: CHEMBL_MEC_689
has molecule: CHEMBL1201735
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_597
type: Mechanism
chembl id: CHEMBL_MEC_597
has molecule: CHEMBL1201732
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_206
type: Mechanism
chembl id: CHEMBL_MEC_206
has molecule: CHEMBL1201732
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_238
type: Mechanism
chembl id: CHEMBL_MEC_238
has molecule: CHEMBL24778
has target: CHEMBL229
mechanism description: Alpha-1a adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1839
type: Mechanism
chembl id: CHEMBL_MEC_1839
has molecule: CHEMBL1237022
has target: CHEMBL2364155
mechanism description: Interleukin-6 receptor alpha subunit inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1420
type: Mechanism
chembl id: CHEMBL_MEC_1420
has molecule: CHEMBL1237023
has target: CHEMBL2364162
mechanism description: Tumor necrosis factor ligand superfamily member 11 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2092
type: Mechanism
chembl id: CHEMBL_MEC_2092
has molecule: CHEMBL1237025
has target: CHEMBL2364183
mechanism description: Uric acid oxidative enzyme
mechanism action type: OXIDATIVE ENZYME

CHEMBL_MEC_242
type: Mechanism
chembl id: CHEMBL_MEC_242
has molecule: CHEMBL1201577
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1377
type: Mechanism
chembl id: CHEMBL_MEC_1377
has molecule: CHEMBL1138
has target: CHEMBL2027
mechanism description: Niemann-Pick C1-like protein 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2141
type: Mechanism
chembl id: CHEMBL_MEC_2141
has molecule: CHEMBL915
mechanism description: Unknown

CHEMBL_MEC_1722
type: Mechanism
chembl id: CHEMBL_MEC_1722
has molecule: CHEMBL1010
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_828
type: Mechanism
chembl id: CHEMBL_MEC_828
has molecule: CHEMBL129
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_584
type: Mechanism
chembl id: CHEMBL_MEC_584
has molecule: CHEMBL1108
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2011
type: Mechanism
chembl id: CHEMBL_MEC_2011
has molecule: CHEMBL1108
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5635
type: Mechanism
chembl id: CHEMBL_MEC_5635
has molecule: CHEMBL90983
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_725
type: Mechanism
chembl id: CHEMBL_MEC_725
has molecule: CHEMBL596
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1913
type: Mechanism
chembl id: CHEMBL_MEC_1913
has molecule: CHEMBL826
has target: CHEMBL2311244
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1642
type: Mechanism
chembl id: CHEMBL_MEC_1642
has molecule: CHEMBL826
has target: CHEMBL2363077
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1051
type: Mechanism
chembl id: CHEMBL_MEC_1051
has molecule: CHEMBL676
has target: CHEMBL1782
mechanism description: Farnesyl diphosphate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_858
type: Mechanism
chembl id: CHEMBL_MEC_858
has molecule: CHEMBL135
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_5041
type: Mechanism
chembl id: CHEMBL_MEC_5041
has molecule: CHEMBL45305
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1450
type: Mechanism
chembl id: CHEMBL_MEC_1450
has molecule: CHEMBL106
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_851
type: Mechanism
chembl id: CHEMBL_MEC_851
has molecule: CHEMBL1026
has target: CHEMBL2056
mechanism description: Dopamine D1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1568
type: Mechanism
chembl id: CHEMBL_MEC_1568
has molecule: CHEMBL781
has target: CHEMBL2363064
mechanism description: Monoamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4702
type: Mechanism
chembl id: CHEMBL_MEC_4702
has molecule: CHEMBL14762
has target: CHEMBL308
mechanism description: Cyclin-dependent kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4700
type: Mechanism
chembl id: CHEMBL_MEC_4700
has molecule: CHEMBL14762
has target: CHEMBL3055
mechanism description: Cyclin-dependent kinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4701
type: Mechanism
chembl id: CHEMBL_MEC_4701
has molecule: CHEMBL14762
has target: CHEMBL3116
mechanism description: Cyclin-dependent kinase 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4703
type: Mechanism
chembl id: CHEMBL_MEC_4703
has molecule: CHEMBL14762
has target: CHEMBL4036
mechanism description: Cyclin-dependent kinase 5 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4699
type: Mechanism
chembl id: CHEMBL_MEC_4699
has molecule: CHEMBL14762
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2100
type: Mechanism
chembl id: CHEMBL_MEC_2100
has molecule: CHEMBL695
has target: CHEMBL2362995
mechanism description: Voltage-gated T-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1710
type: Mechanism
chembl id: CHEMBL_MEC_1710
has molecule: CHEMBL1082
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_764
type: Mechanism
chembl id: CHEMBL_MEC_764
has molecule: CHEMBL632
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_766
type: Mechanism
chembl id: CHEMBL_MEC_766
has molecule: CHEMBL1504
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1624
type: Mechanism
chembl id: CHEMBL_MEC_1624
has molecule: CHEMBL738
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5659
type: Mechanism
chembl id: CHEMBL_MEC_5659
has molecule: CHEMBL371405
has target: CHEMBL3831201
mechanism description: 20S Proteasome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1094
type: Mechanism
chembl id: CHEMBL_MEC_1094
has molecule: CHEMBL284671
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta agonist
mechanism action type: AGONIST

CHEMBL_MEC_1317
type: Mechanism
chembl id: CHEMBL_MEC_1317
has molecule: CHEMBL806
has target: CHEMBL1871
mechanism description: Androgen Receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1730
type: Mechanism
chembl id: CHEMBL_MEC_1730
has molecule: CHEMBL1126
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5734
type: Mechanism
chembl id: CHEMBL_MEC_5734
has molecule: CHEMBL142703
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_342
type: Mechanism
chembl id: CHEMBL_MEC_342
has molecule: CHEMBL406
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_227
type: Mechanism
chembl id: CHEMBL_MEC_227
has molecule: CHEMBL1017
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2263
type: Mechanism
chembl id: CHEMBL_MEC_2263
has molecule: CHEMBL1238
mechanism description: Unknown

CHEMBL_MEC_5711
type: Mechanism
chembl id: CHEMBL_MEC_5711
has molecule: CHEMBL180101
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1493
type: Mechanism
chembl id: CHEMBL_MEC_1493
has molecule: CHEMBL116
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_826
type: Mechanism
chembl id: CHEMBL_MEC_826
has molecule: CHEMBL885
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1677
type: Mechanism
chembl id: CHEMBL_MEC_1677
has molecule: CHEMBL1201043
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_426
type: Mechanism
chembl id: CHEMBL_MEC_426
has molecule: CHEMBL704
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_270
type: Mechanism
chembl id: CHEMBL_MEC_270
has molecule: CHEMBL704
has target: CHEMBL215
mechanism description: Arachidonate 5-lipoxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1202
type: Mechanism
chembl id: CHEMBL_MEC_1202
has molecule: CHEMBL704
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1459
type: Mechanism
chembl id: CHEMBL_MEC_1459
has molecule: CHEMBL599
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1440
type: Mechanism
chembl id: CHEMBL_MEC_1440
has molecule: CHEMBL1282
has target: CHEMBL5936
mechanism description: Toll-like receptor 7 agonist
mechanism action type: AGONIST

CHEMBL_MEC_639
type: Mechanism
chembl id: CHEMBL_MEC_639
has molecule: CHEMBL1201508
has target: CHEMBL1985
mechanism description: Glucagon receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_465
type: Mechanism
chembl id: CHEMBL_MEC_465
has molecule: CHEMBL227529
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_575
type: Mechanism
chembl id: CHEMBL_MEC_575
has molecule: CHEMBL128
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_371
type: Mechanism
chembl id: CHEMBL_MEC_371
has molecule: CHEMBL128
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1251
type: Mechanism
chembl id: CHEMBL_MEC_1251
has molecule: CHEMBL817
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_4590
type: Mechanism
chembl id: CHEMBL_MEC_4590
has molecule: CHEMBL181954
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_4591
type: Mechanism
chembl id: CHEMBL_MEC_4591
has molecule: CHEMBL181954
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_398
type: Mechanism
chembl id: CHEMBL_MEC_398
has molecule: CHEMBL1409
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4947
type: Mechanism
chembl id: CHEMBL_MEC_4947
has molecule: CHEMBL517140
has target: CHEMBL264
mechanism description: Histamine H3 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_288
type: Mechanism
chembl id: CHEMBL_MEC_288
has molecule: CHEMBL1761
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1662
type: Mechanism
chembl id: CHEMBL_MEC_1662
has molecule: CHEMBL455
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1044
type: Mechanism
chembl id: CHEMBL_MEC_1044
has molecule: CHEMBL3
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_4939
type: Mechanism
chembl id: CHEMBL_MEC_4939
has molecule: CHEMBL412262
has target: CHEMBL218
mechanism description: Cannabinoid CB1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_325
type: Mechanism
chembl id: CHEMBL_MEC_325
has molecule: CHEMBL1691
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_153
type: Mechanism
chembl id: CHEMBL_MEC_153
has molecule: CHEMBL1200590
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_565
type: Mechanism
chembl id: CHEMBL_MEC_565
has molecule: CHEMBL1200517
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_347
type: Mechanism
chembl id: CHEMBL_MEC_347
has molecule: CHEMBL1200616
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_517
type: Mechanism
chembl id: CHEMBL_MEC_517
has molecule: CHEMBL1200666
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_401
type: Mechanism
chembl id: CHEMBL_MEC_401
has molecule: CHEMBL1201082
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1698
type: Mechanism
chembl id: CHEMBL_MEC_1698
has molecule: CHEMBL1200544
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2190
type: Mechanism
chembl id: CHEMBL_MEC_2190
has molecule: CHEMBL1200471
mechanism description: Unknown

CHEMBL_MEC_1825
type: Mechanism
chembl id: CHEMBL_MEC_1825
has molecule: CHEMBL64894
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5393
type: Mechanism
chembl id: CHEMBL_MEC_5393
has molecule: CHEMBL61780
has target: CHEMBL1785
mechanism description: Endothelin receptor ET-B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5392
type: Mechanism
chembl id: CHEMBL_MEC_5392
has molecule: CHEMBL61780
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5712
type: Mechanism
chembl id: CHEMBL_MEC_5712
has molecule: CHEMBL520733
has target: CHEMBL2094135
mechanism description: Gamma-secretase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_262
type: Mechanism
chembl id: CHEMBL_MEC_262
has molecule: CHEMBL1200516
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1409
type: Mechanism
chembl id: CHEMBL_MEC_1409
has molecule: CHEMBL1200453
has target: CHEMBL2364696
mechanism description: Envelope glycoprotein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_705
type: Mechanism
chembl id: CHEMBL_MEC_705
has molecule: CHEMBL1200611
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_155
type: Mechanism
chembl id: CHEMBL_MEC_155
has molecule: CHEMBL1200974
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4230
type: Mechanism
chembl id: CHEMBL_MEC_4230
has molecule: CHEMBL494089
has target: CHEMBL2093867
mechanism description: Protein kinase C (PKC) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4229
type: Mechanism
chembl id: CHEMBL_MEC_4229
has molecule: CHEMBL494089
has target: CHEMBL2094138
mechanism description: cAMP-dependent protein kinase (PKA) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4228
type: Mechanism
chembl id: CHEMBL_MEC_4228
has molecule: CHEMBL494089
has target: CHEMBL2111353
mechanism description: Serine/threonine-protein kinase AKT inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4989
type: Mechanism
chembl id: CHEMBL_MEC_4989
has molecule: CHEMBL431733
has target: CHEMBL256
mechanism description: Adenosine A3 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5050
type: Mechanism
chembl id: CHEMBL_MEC_5050
has molecule: CHEMBL303960
has target: CHEMBL1836
mechanism description: Prostanoid EP4 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4057
type: Mechanism
chembl id: CHEMBL_MEC_4057
has molecule: CHEMBL37676
has target: CHEMBL1871
mechanism description: Androgen Receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4557
type: Mechanism
chembl id: CHEMBL_MEC_4557
has molecule: CHEMBL1232583
has target: CHEMBL3559683
mechanism description: Peroxisome proliferator-activated receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1475
type: Mechanism
chembl id: CHEMBL_MEC_1475
has molecule: CHEMBL1200380
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1341
type: Mechanism
chembl id: CHEMBL_MEC_1341
has molecule: CHEMBL1201061
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1404
type: Mechanism
chembl id: CHEMBL_MEC_1404
has molecule: CHEMBL1200493
has target: CHEMBL2364679
mechanism description: Squalene monooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4610
type: Mechanism
chembl id: CHEMBL_MEC_4610
has molecule: CHEMBL565612
has target: CHEMBL2093867
mechanism description: Protein kinase C (PKC) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2335
type: Mechanism
chembl id: CHEMBL_MEC_2335
has molecule: CHEMBL205596
mechanism description: Unknown

CHEMBL_MEC_5737
type: Mechanism
chembl id: CHEMBL_MEC_5737
has molecule: CHEMBL481958
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5723
type: Mechanism
chembl id: CHEMBL_MEC_5723
has molecule: CHEMBL1090771
has target: CHEMBL2094135
mechanism description: Gamma-secretase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5624
type: Mechanism
chembl id: CHEMBL_MEC_5624
has molecule: CHEMBL117287
has target: CHEMBL1875
mechanism description: Serotonin 4 (5-HT4) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1681
type: Mechanism
chembl id: CHEMBL_MEC_1681
has molecule: CHEMBL1604
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4808
type: Mechanism
chembl id: CHEMBL_MEC_4808
has molecule: CHEMBL521851
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2246
type: Mechanism
chembl id: CHEMBL_MEC_2246
has molecule: CHEMBL523299
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2094
type: Mechanism
chembl id: CHEMBL_MEC_2094
has molecule: CHEMBL502097
has target: CHEMBL2364185
mechanism description: Apo-B 100 mRNA antisense inhibitor
mechanism action type: ANTISENSE INHIBITOR

CHEMBL_MEC_2256
type: Mechanism
chembl id: CHEMBL_MEC_2256
has molecule: CHEMBL34259
has target: CHEMBL202
mechanism description: Dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5534
type: Mechanism
chembl id: CHEMBL_MEC_5534
has molecule: CHEMBL1083390
has target: CHEMBL3371
mechanism description: Serotonin 6 (5-HT6) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2045
type: Mechanism
chembl id: CHEMBL_MEC_2045
has molecule: CHEMBL31
has target: CHEMBL2363033
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1911
type: Mechanism
chembl id: CHEMBL_MEC_1911
has molecule: CHEMBL31
has target: CHEMBL2311225
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5149
type: Mechanism
chembl id: CHEMBL_MEC_5149
has molecule: CHEMBL559478
has target: CHEMBL2492
mechanism description: Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_203
type: Mechanism
chembl id: CHEMBL_MEC_203
has molecule: CHEMBL1201102
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1734
type: Mechanism
chembl id: CHEMBL_MEC_1734
has molecule: CHEMBL1200701
has target: CHEMBL2362972
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2262
type: Mechanism
chembl id: CHEMBL_MEC_2262
has molecule: CHEMBL1200628
has target: CHEMBL3041361
mechanism description: Peptidoglycan inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2357
type: Mechanism
chembl id: CHEMBL_MEC_2357
has molecule: CHEMBL1200800
has target: CHEMBL2364184
mechanism description: Phosphate sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_397
type: Mechanism
chembl id: CHEMBL_MEC_397
has molecule: CHEMBL1200781
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1327
type: Mechanism
chembl id: CHEMBL_MEC_1327
has molecule: CHEMBL1200436
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_284
type: Mechanism
chembl id: CHEMBL_MEC_284
has molecule: CHEMBL1201067
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1719
type: Mechanism
chembl id: CHEMBL_MEC_1719
has molecule: CHEMBL1200758
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1098
type: Mechanism
chembl id: CHEMBL_MEC_1098
has molecule: CHEMBL1718
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6175
type: Mechanism
chembl id: CHEMBL_MEC_6175
has molecule: CHEMBL1540
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1252
type: Mechanism
chembl id: CHEMBL_MEC_1252
has molecule: CHEMBL1272
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1467
type: Mechanism
chembl id: CHEMBL_MEC_1467
has molecule: CHEMBL754
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4632
type: Mechanism
chembl id: CHEMBL_MEC_4632
has molecule: CHEMBL445813
has target: CHEMBL3559691
mechanism description: Cyclin-dependent kinase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_883
type: Mechanism
chembl id: CHEMBL_MEC_883
has molecule: CHEMBL1095292
has target: CHEMBL222
mechanism description: Norepinephrine transporter substrate
mechanism action type: SUBSTRATE

CHEMBL_MEC_1388
type: Mechanism
chembl id: CHEMBL_MEC_1388
has molecule: CHEMBL1660
has target: CHEMBL2364672
has binding site: CHEMBL BS 2638
mechanism description: Bacterial DNA-directed RNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4206
type: Mechanism
chembl id: CHEMBL_MEC_4206
has molecule: CHEMBL482967
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4205
type: Mechanism
chembl id: CHEMBL_MEC_4205
has molecule: CHEMBL482967
has target: CHEMBL3430911
mechanism description: Serine/threonine-protein kinase Aurora inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1867
type: Mechanism
chembl id: CHEMBL_MEC_1867
has molecule: CHEMBL1619
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1231
type: Mechanism
chembl id: CHEMBL_MEC_1231
has molecule: CHEMBL1201454
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1071
type: Mechanism
chembl id: CHEMBL_MEC_1071
has molecule: CHEMBL1201467
has target: CHEMBL2093866
mechanism description: Estrogen receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2038
type: Mechanism
chembl id: CHEMBL_MEC_2038
has molecule: CHEMBL1201505
has target: CHEMBL2364709
mechanism description: Fibrinogen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2117
type: Mechanism
chembl id: CHEMBL_MEC_2117
has molecule: CHEMBL1201531
mechanism description: Unknown

CHEMBL_MEC_543
type: Mechanism
chembl id: CHEMBL_MEC_543
has molecule: CHEMBL1201545
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1844
type: Mechanism
chembl id: CHEMBL_MEC_1844
has molecule: CHEMBL1201734
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1532
type: Mechanism
chembl id: CHEMBL_MEC_1532
has molecule: CHEMBL1200549
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4200
type: Mechanism
chembl id: CHEMBL_MEC_4200
has molecule: CHEMBL598797
has target: CHEMBL2093865
mechanism description: Histone deacetylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4198
type: Mechanism
chembl id: CHEMBL_MEC_4198
has molecule: CHEMBL598797
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4199
type: Mechanism
chembl id: CHEMBL_MEC_4199
has molecule: CHEMBL598797
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_537
type: Mechanism
chembl id: CHEMBL_MEC_537
has molecule: CHEMBL1201631
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_530
type: Mechanism
chembl id: CHEMBL_MEC_530
has molecule: CHEMBL1201631
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_254
type: Mechanism
chembl id: CHEMBL_MEC_254
has molecule: CHEMBL1201697
has target: CHEMBL1854
mechanism description: Luteinizing hormone/Choriogonadotropin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_930
type: Mechanism
chembl id: CHEMBL_MEC_930
has molecule: CHEMBL1561
has target: CHEMBL2608
mechanism description: Lysosomal alpha-glucosidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_872
type: Mechanism
chembl id: CHEMBL_MEC_872
has molecule: CHEMBL1561
has target: CHEMBL2074
mechanism description: Maltase-glucoamylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_377
type: Mechanism
chembl id: CHEMBL_MEC_377
has molecule: CHEMBL1720
has target: CHEMBL1899
mechanism description: Serotonin 3a (5-HT3a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_464
type: Mechanism
chembl id: CHEMBL_MEC_464
has molecule: CHEMBL1689
has target: CHEMBL1941
mechanism description: Histamine H2 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1240
type: Mechanism
chembl id: CHEMBL_MEC_1240
has molecule: CHEMBL1689
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_178
type: Mechanism
chembl id: CHEMBL_MEC_178
has molecule: CHEMBL1689
has target: CHEMBL231
mechanism description: Histamine H1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5689
type: Mechanism
chembl id: CHEMBL_MEC_5689
has molecule: CHEMBL416146
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1687
type: Mechanism
chembl id: CHEMBL_MEC_1687
has molecule: CHEMBL1632
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1411
type: Mechanism
chembl id: CHEMBL_MEC_1411
has molecule: CHEMBL1201823
has target: CHEMBL2364156
mechanism description: T-lymphocyte activation antigen CD86 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1412
type: Mechanism
chembl id: CHEMBL_MEC_1412
has molecule: CHEMBL1201823
has target: CHEMBL2364157
mechanism description: T-lymphocyte activation antigen CD80 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_68
type: Mechanism
chembl id: CHEMBL_MEC_68
has molecule: CHEMBL525610
has target: CHEMBL1793
mechanism description: Parathyroid hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1593
type: Mechanism
chembl id: CHEMBL_MEC_1593
has molecule: CHEMBL1522
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5282
type: Mechanism
chembl id: CHEMBL_MEC_5282
has molecule: CHEMBL1088752
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5283
type: Mechanism
chembl id: CHEMBL_MEC_5283
has molecule: CHEMBL1088752
has target: CHEMBL3961
mechanism description: MAP kinase p38 beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_876
type: Mechanism
chembl id: CHEMBL_MEC_876
has molecule: CHEMBL1118
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_393
type: Mechanism
chembl id: CHEMBL_MEC_393
has molecule: CHEMBL1118
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4312
type: Mechanism
chembl id: CHEMBL_MEC_4312
has molecule: CHEMBL1084546
has target: CHEMBL2695
mechanism description: Focal adhesion kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1149
type: Mechanism
chembl id: CHEMBL_MEC_1149
has molecule: CHEMBL677
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_899
type: Mechanism
chembl id: CHEMBL_MEC_899
has molecule: CHEMBL1113
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_407
type: Mechanism
chembl id: CHEMBL_MEC_407
has molecule: CHEMBL1113
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1152
type: Mechanism
chembl id: CHEMBL_MEC_1152
has molecule: CHEMBL1113
has target: CHEMBL2096905
mechanism description: Dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_461
type: Mechanism
chembl id: CHEMBL_MEC_461
has molecule: CHEMBL30
has target: CHEMBL1941
mechanism description: Histamine H2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1709
type: Mechanism
chembl id: CHEMBL_MEC_1709
has molecule: CHEMBL1605
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_864
type: Mechanism
chembl id: CHEMBL_MEC_864
has molecule: CHEMBL1200973
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_429
type: Mechanism
chembl id: CHEMBL_MEC_429
has molecule: CHEMBL1201616
has target: CHEMBL1925
mechanism description: Secretin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1508
type: Mechanism
chembl id: CHEMBL_MEC_1508
has molecule: CHEMBL1201765
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_38
type: Mechanism
chembl id: CHEMBL_MEC_38
has molecule: CHEMBL1201765
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1147
type: Mechanism
chembl id: CHEMBL_MEC_1147
has molecule: CHEMBL459
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1089
type: Mechanism
chembl id: CHEMBL_MEC_1089
has molecule: CHEMBL1201470
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta agonist
mechanism action type: AGONIST

CHEMBL_MEC_355
type: Mechanism
chembl id: CHEMBL_MEC_355
has molecule: CHEMBL1587
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_107
type: Mechanism
chembl id: CHEMBL_MEC_107
has molecule: CHEMBL1519
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_241
type: Mechanism
chembl id: CHEMBL_MEC_241
has molecule: CHEMBL1201827
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1067
type: Mechanism
chembl id: CHEMBL_MEC_1067
has molecule: CHEMBL1213490
has target: CHEMBL2093865
mechanism description: Histone deacetylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5674
type: Mechanism
chembl id: CHEMBL_MEC_5674
has molecule: CHEMBL1173055
has target: CHEMBL3390820
mechanism description: PARP 1, 2 and 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1743
type: Mechanism
chembl id: CHEMBL_MEC_1743
has molecule: CHEMBL1201780
has target: CHEMBL2362990
mechanism description: Carbamoyl-phosphate synthase [ammonia], mitochondrial positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1287
type: Mechanism
chembl id: CHEMBL_MEC_1287
has molecule: CHEMBL1677
has target: CHEMBL2095233
mechanism description: Cholinesterases; ACHE & BCHE inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5647
type: Mechanism
chembl id: CHEMBL_MEC_5647
has molecule: CHEMBL315985
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_885
type: Mechanism
chembl id: CHEMBL_MEC_885
has molecule: CHEMBL1702
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2029
type: Mechanism
chembl id: CHEMBL_MEC_2029
has molecule: CHEMBL1712
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_629
type: Mechanism
chembl id: CHEMBL_MEC_629
has molecule: CHEMBL1712
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_612
type: Mechanism
chembl id: CHEMBL_MEC_612
has molecule: CHEMBL1712
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5025
type: Mechanism
chembl id: CHEMBL_MEC_5025
has molecule: CHEMBL1096896
has target: CHEMBL251
mechanism description: Adenosine A2a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1421
type: Mechanism
chembl id: CHEMBL_MEC_1421
has molecule: CHEMBL1201828
has target: CHEMBL2364163
mechanism description: Complement C5 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_681
type: Mechanism
chembl id: CHEMBL_MEC_681
has molecule: CHEMBL1201056
has target: CHEMBL2013
mechanism description: Dihydropteroate synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2054
type: Mechanism
chembl id: CHEMBL_MEC_2054
has molecule: CHEMBL1200733
has target: CHEMBL2321614
mechanism description: Potassium channel subfamily K member 9 opener
mechanism action type: OPENER

CHEMBL_MEC_2060
type: Mechanism
chembl id: CHEMBL_MEC_2060
has molecule: CHEMBL1200733
has target: CHEMBL2321615
mechanism description: Potassium channel subfamily K member 2 opener
mechanism action type: OPENER

CHEMBL_MEC_1940
type: Mechanism
chembl id: CHEMBL_MEC_1940
has molecule: CHEMBL1200733
has target: CHEMBL2331041
mechanism description: Potassium channel subfamily K member 10 opener
mechanism action type: OPENER

CHEMBL_MEC_1945
type: Mechanism
chembl id: CHEMBL_MEC_1945
has molecule: CHEMBL1200733
has target: CHEMBL2331042
mechanism description: Potassium channel subfamily K member 18 opener
mechanism action type: OPENER

CHEMBL_MEC_1550
type: Mechanism
chembl id: CHEMBL_MEC_1550
has molecule: CHEMBL1200733
has target: CHEMBL2363052
has binding site: CHEMBL BS 2639
mechanism description: Glycine receptor (alpha-1/beta) positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_2048
type: Mechanism
chembl id: CHEMBL_MEC_2048
has molecule: CHEMBL1200733
has target: CHEMBL2321613
mechanism description: Potassium channel subfamily K member 3 opener
mechanism action type: OPENER

CHEMBL_MEC_1601
type: Mechanism
chembl id: CHEMBL_MEC_1601
has molecule: CHEMBL1200733
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1210
type: Mechanism
chembl id: CHEMBL_MEC_1210
has molecule: CHEMBL452231
has target: CHEMBL2094255
mechanism description: DNA topoisomerase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1061
type: Mechanism
chembl id: CHEMBL_MEC_1061
has molecule: CHEMBL1752
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1382
type: Mechanism
chembl id: CHEMBL_MEC_1382
has molecule: CHEMBL1752
has target: CHEMBL241
mechanism description: Phosphodiesterase 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_491
type: Mechanism
chembl id: CHEMBL_MEC_491
has molecule: CHEMBL1201532
has target: CHEMBL1963
mechanism description: Thyroid stimulating hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_378
type: Mechanism
chembl id: CHEMBL_MEC_378
has molecule: CHEMBL1201111
has target: CHEMBL1899
mechanism description: Serotonin 3a (5-HT3a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4085
type: Mechanism
chembl id: CHEMBL_MEC_4085
has molecule: CHEMBL284121
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_825
type: Mechanism
chembl id: CHEMBL_MEC_825
has molecule: CHEMBL1486
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5649
type: Mechanism
chembl id: CHEMBL_MEC_5649
has molecule: CHEMBL289351
has target: CHEMBL2095182
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1535
type: Mechanism
chembl id: CHEMBL_MEC_1535
has molecule: CHEMBL1739
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1048
type: Mechanism
chembl id: CHEMBL_MEC_1048
has molecule: CHEMBL1654
has target: CHEMBL1782
mechanism description: Farnesyl diphosphate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1168
type: Mechanism
chembl id: CHEMBL_MEC_1168
has molecule: CHEMBL1558
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6166
type: Mechanism
chembl id: CHEMBL_MEC_6166
has molecule: CHEMBL1201891
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1566
type: Mechanism
chembl id: CHEMBL_MEC_1566
has molecule: CHEMBL41355
has target: CHEMBL2363063
mechanism description: KCNQ (Kv7) potassium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1474
type: Mechanism
chembl id: CHEMBL_MEC_1474
has molecule: CHEMBL1090
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5184
type: Mechanism
chembl id: CHEMBL_MEC_5184
has molecule: CHEMBL41306
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor blocker
mechanism action type: BLOCKER

CHEMBL_MEC_5073
type: Mechanism
chembl id: CHEMBL_MEC_5073
has molecule: CHEMBL431651
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5074
type: Mechanism
chembl id: CHEMBL_MEC_5074
has molecule: CHEMBL431651
has target: CHEMBL1785
mechanism description: Endothelin receptor ET-B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4872
type: Mechanism
chembl id: CHEMBL_MEC_4872
has molecule: CHEMBL105060
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5637
type: Mechanism
chembl id: CHEMBL_MEC_5637
has molecule: CHEMBL235191
has target: CHEMBL2093865
mechanism description: Histone deacetylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4594
type: Mechanism
chembl id: CHEMBL_MEC_4594
has molecule: CHEMBL490029
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4924
type: Mechanism
chembl id: CHEMBL_MEC_4924
has molecule: CHEMBL291657
has target: CHEMBL1800
mechanism description: Corticotropin releasing factor receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1490
type: Mechanism
chembl id: CHEMBL_MEC_1490
has molecule: CHEMBL282042
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_302
type: Mechanism
chembl id: CHEMBL_MEC_302
has molecule: CHEMBL288441
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_682
type: Mechanism
chembl id: CHEMBL_MEC_682
has molecule: CHEMBL288441
has target: CHEMBL267
mechanism description: Tyrosine-protein kinase SRC inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_940
type: Mechanism
chembl id: CHEMBL_MEC_940
has molecule: CHEMBL288441
has target: CHEMBL3905
mechanism description: Tyrosine-protein kinase Lyn inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_926
type: Mechanism
chembl id: CHEMBL_MEC_926
has molecule: CHEMBL288441
has target: CHEMBL3234
mechanism description: Tyrosine-protein kinase HCK inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_55
type: Mechanism
chembl id: CHEMBL_MEC_55
has molecule: CHEMBL1201421
has target: CHEMBL1783
mechanism description: Vascular endothelial growth factor A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_487
type: Mechanism
chembl id: CHEMBL_MEC_487
has molecule: CHEMBL1201717
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_439
type: Mechanism
chembl id: CHEMBL_MEC_439
has molecule: CHEMBL1467
has target: CHEMBL1929
mechanism description: Xanthine dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_518
type: Mechanism
chembl id: CHEMBL_MEC_518
has molecule: CHEMBL1200622
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2172
type: Mechanism
chembl id: CHEMBL_MEC_2172
has molecule: CHEMBL1200709
mechanism description: Unknown

CHEMBL_MEC_1362
type: Mechanism
chembl id: CHEMBL_MEC_1362
has molecule: CHEMBL1200920
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1723
type: Mechanism
chembl id: CHEMBL_MEC_1723
has molecule: CHEMBL1201016
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_67
type: Mechanism
chembl id: CHEMBL_MEC_67
has molecule: CHEMBL1201184
has target: CHEMBL1792
mechanism description: Somatostatin receptor 5 agonist
mechanism action type: AGONIST

CHEMBL_MEC_95
type: Mechanism
chembl id: CHEMBL_MEC_95
has molecule: CHEMBL1201184
has target: CHEMBL1804
mechanism description: Somatostatin receptor 2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_539
type: Mechanism
chembl id: CHEMBL_MEC_539
has molecule: CHEMBL1201653
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_574
type: Mechanism
chembl id: CHEMBL_MEC_574
has molecule: CHEMBL1201150
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_372
type: Mechanism
chembl id: CHEMBL_MEC_372
has molecule: CHEMBL1201150
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_521
type: Mechanism
chembl id: CHEMBL_MEC_521
has molecule: CHEMBL1200810
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_70
type: Mechanism
chembl id: CHEMBL_MEC_70
has molecule: CHEMBL175247
has target: CHEMBL1796
mechanism description: Gastric lipase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_122
type: Mechanism
chembl id: CHEMBL_MEC_122
has molecule: CHEMBL175247
has target: CHEMBL1812
mechanism description: Pancreatic lipase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_140
type: Mechanism
chembl id: CHEMBL_MEC_140
has molecule: CHEMBL1200809
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1194
type: Mechanism
chembl id: CHEMBL_MEC_1194
has molecule: CHEMBL563
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4807
type: Mechanism
chembl id: CHEMBL_MEC_4807
has molecule: CHEMBL558752
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4806
type: Mechanism
chembl id: CHEMBL_MEC_4806
has molecule: CHEMBL558752
has target: CHEMBL5145
mechanism description: Serine/threonine-protein kinase B-raf inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4995
type: Mechanism
chembl id: CHEMBL_MEC_4995
has molecule: CHEMBL560993
has target: CHEMBL5071
mechanism description: G protein-coupled receptor 44 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2110
type: Mechanism
chembl id: CHEMBL_MEC_2110
has molecule: CHEMBL252518
mechanism description: Unknown

CHEMBL_MEC_5390
type: Mechanism
chembl id: CHEMBL_MEC_5390
has molecule: CHEMBL266125
has target: CHEMBL2327
mechanism description: Neurokinin 2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_768
type: Mechanism
chembl id: CHEMBL_MEC_768
has molecule: CHEMBL1159650
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4162
type: Mechanism
chembl id: CHEMBL_MEC_4162
has molecule: CHEMBL258940
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5077
type: Mechanism
chembl id: CHEMBL_MEC_5077
has molecule: CHEMBL329123
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5076
type: Mechanism
chembl id: CHEMBL_MEC_5076
has molecule: CHEMBL329123
has target: CHEMBL3911
mechanism description: Leukotriene B4 receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4138
type: Mechanism
chembl id: CHEMBL_MEC_4138
has molecule: CHEMBL488436
has target: CHEMBL3559691
mechanism description: Cyclin-dependent kinase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_476
type: Mechanism
chembl id: CHEMBL_MEC_476
has molecule: CHEMBL1201476
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_2134
type: Mechanism
chembl id: CHEMBL_MEC_2134
has molecule: CHEMBL301267
mechanism description: Unknown

CHEMBL_MEC_4463
type: Mechanism
chembl id: CHEMBL_MEC_4463
has molecule: CHEMBL440115
has target: CHEMBL226
mechanism description: Adenosine A1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5375
type: Mechanism
chembl id: CHEMBL_MEC_5375
has molecule: CHEMBL240624
has target: CHEMBL251
mechanism description: Adenosine A2a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_732
type: Mechanism
chembl id: CHEMBL_MEC_732
has molecule: CHEMBL299400
has target: CHEMBL233
mechanism description: Mu opioid receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_1313
type: Mechanism
chembl id: CHEMBL_MEC_1313
has molecule: CHEMBL299400
has target: CHEMBL237
mechanism description: Kappa opioid receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_5784
type: Mechanism
chembl id: CHEMBL_MEC_5784
has molecule: CHEMBL166863
has target: CHEMBL230
mechanism description: Cyclooxygenase-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5835
type: Mechanism
chembl id: CHEMBL_MEC_5835
has molecule: CHEMBL166863
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5836
type: Mechanism
chembl id: CHEMBL_MEC_5836
has molecule: CHEMBL166863
has target: CHEMBL261
mechanism description: Carbonic anhydrase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5299
type: Mechanism
chembl id: CHEMBL_MEC_5299
has molecule: CHEMBL300138
has target: CHEMBL3045
mechanism description: Protein kinase C beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5710
type: Mechanism
chembl id: CHEMBL_MEC_5710
has molecule: CHEMBL197672
has target: CHEMBL3831289
mechanism description: Caspase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2292
type: Mechanism
chembl id: CHEMBL_MEC_2292
has molecule: CHEMBL443052
has target: CHEMBL3307222
mechanism description: Leucine-tRNA ligase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4842
type: Mechanism
chembl id: CHEMBL_MEC_4842
has molecule: CHEMBL462018
has target: CHEMBL2111353
mechanism description: Serine/threonine-protein kinase AKT inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4503
type: Mechanism
chembl id: CHEMBL_MEC_4503
has molecule: CHEMBL504652
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5049
type: Mechanism
chembl id: CHEMBL_MEC_5049
has molecule: CHEMBL261244
has target: CHEMBL2001
mechanism description: Purinergic receptor P2Y12 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5700
type: Mechanism
chembl id: CHEMBL_MEC_5700
has molecule: CHEMBL550755
has target: CHEMBL4338
mechanism description: Purine nucleoside phosphorylase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1647
type: Mechanism
chembl id: CHEMBL_MEC_1647
has molecule: CHEMBL446
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_581
type: Mechanism
chembl id: CHEMBL_MEC_581
has molecule: CHEMBL71
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2005
type: Mechanism
chembl id: CHEMBL_MEC_2005
has molecule: CHEMBL71
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_358
type: Mechanism
chembl id: CHEMBL_MEC_358
has molecule: CHEMBL495
has target: CHEMBL1881
mechanism description: Prostanoid EP2 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_120
type: Mechanism
chembl id: CHEMBL_MEC_120
has molecule: CHEMBL495
has target: CHEMBL1811
mechanism description: Prostanoid EP1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2334
type: Mechanism
chembl id: CHEMBL_MEC_2334
has molecule: CHEMBL139367
has target: CHEMBL2051
mechanism description: Neuraminidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2333
type: Mechanism
chembl id: CHEMBL_MEC_2333
has molecule: CHEMBL139367
has target: CHEMBL3377
mechanism description: Neuraminidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1206
type: Mechanism
chembl id: CHEMBL_MEC_1206
has molecule: CHEMBL527
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1180
type: Mechanism
chembl id: CHEMBL_MEC_1180
has molecule: CHEMBL521
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4785
type: Mechanism
chembl id: CHEMBL_MEC_4785
has molecule: CHEMBL1234354
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4786
type: Mechanism
chembl id: CHEMBL_MEC_4786
has molecule: CHEMBL1234354
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4251
type: Mechanism
chembl id: CHEMBL_MEC_4251
has molecule: CHEMBL406381
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1047
type: Mechanism
chembl id: CHEMBL_MEC_1047
has molecule: CHEMBL675
has target: CHEMBL1782
mechanism description: Farnesyl diphosphate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1110
type: Mechanism
chembl id: CHEMBL_MEC_1110
has molecule: CHEMBL378544
has target: CHEMBL2095182
has binding site: CHEMBL BS 2627
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_339
type: Mechanism
chembl id: CHEMBL_MEC_339
has molecule: CHEMBL1148
has target: CHEMBL1874
mechanism description: Sodium-(potassium)-chloride cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1012
type: Mechanism
chembl id: CHEMBL_MEC_1012
has molecule: CHEMBL1201139
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1491
type: Mechanism
chembl id: CHEMBL_MEC_1491
has molecule: CHEMBL163
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5705
type: Mechanism
chembl id: CHEMBL_MEC_5705
has molecule: CHEMBL190083
has target: CHEMBL2094135
mechanism description: Gamma-secretase modulator
mechanism action type: MODULATOR

CHEMBL_MEC_1376
type: Mechanism
chembl id: CHEMBL_MEC_1376
has molecule: CHEMBL1518
has target: CHEMBL2019
mechanism description: Type I iodothyronine deiodinase (Type-I 5'deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_232
type: Mechanism
chembl id: CHEMBL_MEC_232
has molecule: CHEMBL1518
has target: CHEMBL1839
mechanism description: Thyroid peroxidase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5310
type: Mechanism
chembl id: CHEMBL_MEC_5310
has molecule: CHEMBL1091644
has target: CHEMBL1981
mechanism description: Insulin receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5309
type: Mechanism
chembl id: CHEMBL_MEC_5309
has molecule: CHEMBL1091644
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4514
type: Mechanism
chembl id: CHEMBL_MEC_4514
has molecule: CHEMBL214268
has target: CHEMBL2492
mechanism description: Neuronal acetylcholine receptor protein alpha-7 subunit agonist
mechanism action type: AGONIST

CHEMBL_MEC_5434
type: Mechanism
chembl id: CHEMBL_MEC_5434
has molecule: CHEMBL572881
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5437
type: Mechanism
chembl id: CHEMBL_MEC_5437
has molecule: CHEMBL572881
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5435
type: Mechanism
chembl id: CHEMBL_MEC_5435
has molecule: CHEMBL572881
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5436
type: Mechanism
chembl id: CHEMBL_MEC_5436
has molecule: CHEMBL572881
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_664
type: Mechanism
chembl id: CHEMBL_MEC_664
has molecule: CHEMBL1237119
has target: CHEMBL1995
mechanism description: Prostanoid IP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_878
type: Mechanism
chembl id: CHEMBL_MEC_878
has molecule: CHEMBL1237135
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5090
type: Mechanism
chembl id: CHEMBL_MEC_5090
has molecule: CHEMBL1090488
has target: CHEMBL259
mechanism description: Melanocortin receptor 4 agonist
mechanism action type: AGONIST

CHEMBL_MEC_5338
type: Mechanism
chembl id: CHEMBL_MEC_5338
has molecule: CHEMBL522892
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5339
type: Mechanism
chembl id: CHEMBL_MEC_5339
has molecule: CHEMBL522892
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5337
type: Mechanism
chembl id: CHEMBL_MEC_5337
has molecule: CHEMBL522892
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5340
type: Mechanism
chembl id: CHEMBL_MEC_5340
has molecule: CHEMBL522892
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5336
type: Mechanism
chembl id: CHEMBL_MEC_5336
has molecule: CHEMBL522892
has target: CHEMBL2742
mechanism description: Fibroblast growth factor receptor 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1854
type: Mechanism
chembl id: CHEMBL_MEC_1854
has molecule: CHEMBL1237054
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_704
type: Mechanism
chembl id: CHEMBL_MEC_704
has molecule: CHEMBL1237055
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_707
type: Mechanism
chembl id: CHEMBL_MEC_707
has molecule: CHEMBL1237065
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2145
type: Mechanism
chembl id: CHEMBL_MEC_2145
has molecule: CHEMBL1237068
mechanism description: Colonic bacteria substrate

CHEMBL_MEC_1392
type: Mechanism
chembl id: CHEMBL_MEC_1392
has molecule: CHEMBL1237070
has target: CHEMBL2364673
mechanism description: 1,3-beta-glucan synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_375
type: Mechanism
chembl id: CHEMBL_MEC_375
has molecule: CHEMBL1237080
has target: CHEMBL1899
mechanism description: Serotonin 3a (5-HT3a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1291
type: Mechanism
chembl id: CHEMBL_MEC_1291
has molecule: CHEMBL1237082
has target: CHEMBL1907594
mechanism description: Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1531
type: Mechanism
chembl id: CHEMBL_MEC_1531
has molecule: CHEMBL1237099
has target: CHEMBL2362997
mechanism description: Muscle-type nicotinic acetylcholine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_719
type: Mechanism
chembl id: CHEMBL_MEC_719
has molecule: CHEMBL1237104
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_646
type: Mechanism
chembl id: CHEMBL_MEC_646
has molecule: CHEMBL1237105
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4790
type: Mechanism
chembl id: CHEMBL_MEC_4790
has molecule: CHEMBL1088751
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4836
type: Mechanism
chembl id: CHEMBL_MEC_4836
has molecule: CHEMBL574737
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4837
type: Mechanism
chembl id: CHEMBL_MEC_4837
has molecule: CHEMBL574737
has target: CHEMBL331
mechanism description: Cyclin-dependent kinase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4841
type: Mechanism
chembl id: CHEMBL_MEC_4841
has molecule: CHEMBL574737
has target: CHEMBL2093867
mechanism description: Protein kinase C (PKC) inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4840
type: Mechanism
chembl id: CHEMBL_MEC_4840
has molecule: CHEMBL574737
has target: CHEMBL2534
mechanism description: 3-phosphoinositide dependent protein kinase-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4839
type: Mechanism
chembl id: CHEMBL_MEC_4839
has molecule: CHEMBL574737
has target: CHEMBL4630
mechanism description: Serine/threonine-protein kinase Chk1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4838
type: Mechanism
chembl id: CHEMBL_MEC_4838
has molecule: CHEMBL574737
has target: CHEMBL2508
mechanism description: Cyclin-dependent kinase 6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5285
type: Mechanism
chembl id: CHEMBL_MEC_5285
has molecule: CHEMBL180022
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5286
type: Mechanism
chembl id: CHEMBL_MEC_5286
has molecule: CHEMBL180022
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_481
type: Mechanism
chembl id: CHEMBL_MEC_481
has molecule: CHEMBL1201448
has target: CHEMBL1950
mechanism description: Antithrombin-III activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_218
type: Mechanism
chembl id: CHEMBL_MEC_218
has molecule: CHEMBL1201661
has target: CHEMBL1832
mechanism description: Calcitonin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2016
type: Mechanism
chembl id: CHEMBL_MEC_2016
has molecule: CHEMBL1764
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4568
type: Mechanism
chembl id: CHEMBL_MEC_4568
has molecule: CHEMBL450940
has target: CHEMBL242
mechanism description: Estrogen receptor beta agonist
mechanism action type: AGONIST

CHEMBL_MEC_1686
type: Mechanism
chembl id: CHEMBL_MEC_1686
has molecule: CHEMBL158
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4614
type: Mechanism
chembl id: CHEMBL_MEC_4614
has molecule: CHEMBL587723
has target: CHEMBL1868
mechanism description: Vascular endothelial growth factor receptor 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4612
type: Mechanism
chembl id: CHEMBL_MEC_4612
has molecule: CHEMBL587723
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4613
type: Mechanism
chembl id: CHEMBL_MEC_4613
has molecule: CHEMBL587723
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4611
type: Mechanism
chembl id: CHEMBL_MEC_4611
has molecule: CHEMBL587723
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_528
type: Mechanism
chembl id: CHEMBL_MEC_528
has molecule: CHEMBL1200612
has target: CHEMBL1980
mechanism description: Sodium channel protein type V alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1007
type: Mechanism
chembl id: CHEMBL_MEC_1007
has molecule: CHEMBL1200612
has target: CHEMBL5451
mechanism description: Sodium channel protein type X alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1953
type: Mechanism
chembl id: CHEMBL_MEC_1953
has molecule: CHEMBL1200654
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_176
type: Mechanism
chembl id: CHEMBL_MEC_176
has molecule: CHEMBL1201023
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1130
type: Mechanism
chembl id: CHEMBL_MEC_1130
has molecule: CHEMBL1201023
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1979
type: Mechanism
chembl id: CHEMBL_MEC_1979
has molecule: CHEMBL1201023
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_913
type: Mechanism
chembl id: CHEMBL_MEC_913
has molecule: CHEMBL1201023
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1712
type: Mechanism
chembl id: CHEMBL_MEC_1712
has molecule: CHEMBL1201098
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1301
type: Mechanism
chembl id: CHEMBL_MEC_1301
has molecule: CHEMBL1201119
has target: CHEMBL2111462
mechanism description: Thyroid hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_309
type: Mechanism
chembl id: CHEMBL_MEC_309
has molecule: CHEMBL24
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1851
type: Mechanism
chembl id: CHEMBL_MEC_1851
has molecule: CHEMBL820
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_222
type: Mechanism
chembl id: CHEMBL_MEC_222
has molecule: CHEMBL1069
has target: CHEMBL227
mechanism description: Type-1 angiotensin II receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1959
type: Mechanism
chembl id: CHEMBL_MEC_1959
has molecule: CHEMBL1200437
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1480
type: Mechanism
chembl id: CHEMBL_MEC_1480
has molecule: CHEMBL1200515
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1395
type: Mechanism
chembl id: CHEMBL_MEC_1395
has molecule: CHEMBL1200842
has target: CHEMBL2364676
mechanism description: Nematode GABA-A receptor positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1726
type: Mechanism
chembl id: CHEMBL_MEC_1726
has molecule: CHEMBL127
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1853
type: Mechanism
chembl id: CHEMBL_MEC_1853
has molecule: CHEMBL414804
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4975
type: Mechanism
chembl id: CHEMBL_MEC_4975
has molecule: CHEMBL1272307
has target: CHEMBL5113
mechanism description: Orexin receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4976
type: Mechanism
chembl id: CHEMBL_MEC_4976
has molecule: CHEMBL1272307
has target: CHEMBL4792
mechanism description: Orexin receptor 2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5688
type: Mechanism
chembl id: CHEMBL_MEC_5688
has molecule: CHEMBL431770
has target: CHEMBL251
mechanism description: Adenosine A2a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1250
type: Mechanism
chembl id: CHEMBL_MEC_1250
has molecule: CHEMBL1589
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2137
type: Mechanism
chembl id: CHEMBL_MEC_2137
has molecule: CHEMBL542541
mechanism description: Unknown

CHEMBL_MEC_4424
type: Mechanism
chembl id: CHEMBL_MEC_4424
has molecule: CHEMBL571948
has target: CHEMBL2111459
mechanism description: Rho-associated protein kinase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_136
type: Mechanism
chembl id: CHEMBL_MEC_136
has molecule: CHEMBL1716
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_717
type: Mechanism
chembl id: CHEMBL_MEC_717
has molecule: CHEMBL1701
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4107
type: Mechanism
chembl id: CHEMBL_MEC_4107
has molecule: CHEMBL496102
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4819
type: Mechanism
chembl id: CHEMBL_MEC_4819
has molecule: CHEMBL514201
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5643
type: Mechanism
chembl id: CHEMBL_MEC_5643
has molecule: CHEMBL591118
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_359
type: Mechanism
chembl id: CHEMBL_MEC_359
has molecule: CHEMBL1770
has target: CHEMBL1884
mechanism description: Nicotinic acetylcholine receptor alpha subunit agonist
mechanism action type: AGONIST

CHEMBL_MEC_156
type: Mechanism
chembl id: CHEMBL_MEC_156
has molecule: CHEMBL1201747
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_617
type: Mechanism
chembl id: CHEMBL_MEC_617
has molecule: CHEMBL1200938
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_471
type: Mechanism
chembl id: CHEMBL_MEC_471
has molecule: CHEMBL1200938
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_229
type: Mechanism
chembl id: CHEMBL_MEC_229
has molecule: CHEMBL1200938
has target: CHEMBL1833
mechanism description: Serotonin 2b (5-HT2b) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1661
type: Mechanism
chembl id: CHEMBL_MEC_1661
has molecule: CHEMBL1200359
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_616
type: Mechanism
chembl id: CHEMBL_MEC_616
has molecule: CHEMBL1200426
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_292
type: Mechanism
chembl id: CHEMBL_MEC_292
has molecule: CHEMBL1200426
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1560
type: Mechanism
chembl id: CHEMBL_MEC_1560
has molecule: CHEMBL1200783
has target: CHEMBL2363057
mechanism description: Copper chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1353
type: Mechanism
chembl id: CHEMBL_MEC_1353
has molecule: CHEMBL1200947
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_317
type: Mechanism
chembl id: CHEMBL_MEC_317
has molecule: CHEMBL1200947
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_896
type: Mechanism
chembl id: CHEMBL_MEC_896
has molecule: CHEMBL1200483
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_702
type: Mechanism
chembl id: CHEMBL_MEC_702
has molecule: CHEMBL1200483
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2144
type: Mechanism
chembl id: CHEMBL_MEC_2144
has molecule: CHEMBL1200747
mechanism description: Unknown

CHEMBL_MEC_1666
type: Mechanism
chembl id: CHEMBL_MEC_1666
has molecule: CHEMBL1201080
has target: CHEMBL2364669
mechanism description: Bacterial dihydrofolate reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1654
type: Mechanism
chembl id: CHEMBL_MEC_1654
has molecule: CHEMBL1200321
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_324
type: Mechanism
chembl id: CHEMBL_MEC_324
has molecule: CHEMBL1200898
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_174
type: Mechanism
chembl id: CHEMBL_MEC_174
has molecule: CHEMBL1200959
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1124
type: Mechanism
chembl id: CHEMBL_MEC_1124
has molecule: CHEMBL1201002
has target: CHEMBL2094118
mechanism description: Adrenergic receptor beta antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1678
type: Mechanism
chembl id: CHEMBL_MEC_1678
has molecule: CHEMBL1200991
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_468
type: Mechanism
chembl id: CHEMBL_MEC_468
has molecule: CHEMBL1201743
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1350
type: Mechanism
chembl id: CHEMBL_MEC_1350
has molecule: CHEMBL1200812
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1623
type: Mechanism
chembl id: CHEMBL_MEC_1623
has molecule: CHEMBL1201065
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1786
type: Mechanism
chembl id: CHEMBL_MEC_1786
has molecule: CHEMBL1200688
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1017
type: Mechanism
chembl id: CHEMBL_MEC_1017
has molecule: CHEMBL1200853
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_780
type: Mechanism
chembl id: CHEMBL_MEC_780
has molecule: CHEMBL1200637
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_886
type: Mechanism
chembl id: CHEMBL_MEC_886
has molecule: CHEMBL1200912
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1707
type: Mechanism
chembl id: CHEMBL_MEC_1707
has molecule: CHEMBL1200768
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1977
type: Mechanism
chembl id: CHEMBL_MEC_1977
has molecule: CHEMBL1200334
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1132
type: Mechanism
chembl id: CHEMBL_MEC_1132
has molecule: CHEMBL1714
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5662
type: Mechanism
chembl id: CHEMBL_MEC_5662
has molecule: CHEMBL506871
has target: CHEMBL3390820
mechanism description: PARP 1, 2 and 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1451
type: Mechanism
chembl id: CHEMBL_MEC_1451
has molecule: CHEMBL1200348
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_783
type: Mechanism
chembl id: CHEMBL_MEC_783
has molecule: CHEMBL1200386
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1171
type: Mechanism
chembl id: CHEMBL_MEC_1171
has molecule: CHEMBL1241153
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_435
type: Mechanism
chembl id: CHEMBL_MEC_435
has molecule: CHEMBL981
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_5818
type: Mechanism
chembl id: CHEMBL_MEC_5818
has molecule: CHEMBL1241348
has target: CHEMBL2095231
mechanism description: Hepatitis C virus serine protease, NS3/NS4A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5520
type: Mechanism
chembl id: CHEMBL_MEC_5520
has molecule: CHEMBL1255654
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1823
type: Mechanism
chembl id: CHEMBL_MEC_1823
has molecule: CHEMBL1256137
has target: CHEMBL2364039
mechanism description: Cystine reducing agent
mechanism action type: REDUCING AGENT

CHEMBL_MEC_5295
type: Mechanism
chembl id: CHEMBL_MEC_5295
has molecule: CHEMBL1289494
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2311
type: Mechanism
chembl id: CHEMBL_MEC_2311
has molecule: CHEMBL1256391
mechanism description: Unknown

CHEMBL_MEC_2247
type: Mechanism
chembl id: CHEMBL_MEC_2247
has molecule: CHEMBL1259059
has target: CHEMBL5375
mechanism description: Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5084
type: Mechanism
chembl id: CHEMBL_MEC_5084
has molecule: CHEMBL1256717
has target: CHEMBL298
mechanism description: Cholecystokinin B receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4863
type: Mechanism
chembl id: CHEMBL_MEC_4863
has molecule: CHEMBL586701
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1264
type: Mechanism
chembl id: CHEMBL_MEC_1264
has molecule: CHEMBL1289926
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1998
type: Mechanism
chembl id: CHEMBL_MEC_1998
has molecule: CHEMBL1256958
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5326
type: Mechanism
chembl id: CHEMBL_MEC_5326
has molecule: CHEMBL1287853
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5327
type: Mechanism
chembl id: CHEMBL_MEC_5327
has molecule: CHEMBL1287853
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4874
type: Mechanism
chembl id: CHEMBL_MEC_4874
has molecule: CHEMBL1287935
has target: CHEMBL1800
mechanism description: Corticotropin releasing factor receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1292
type: Mechanism
chembl id: CHEMBL_MEC_1292
has molecule: CHEMBL1318287
has target: CHEMBL1907594
mechanism description: Neuronal acetylcholine receptor; alpha3/beta4 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4406
type: Mechanism
chembl id: CHEMBL_MEC_4406
has molecule: CHEMBL1320667
mechanism description: Unknown

CHEMBL_MEC_5011
type: Mechanism
chembl id: CHEMBL_MEC_5011
has molecule: CHEMBL1254771
has target: CHEMBL4308
mechanism description: Bradykinin B1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5200
type: Mechanism
chembl id: CHEMBL_MEC_5200
has molecule: CHEMBL1277001
has target: CHEMBL2096670
mechanism description: Glutamate receptor ionotropic AMPA positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5278
type: Mechanism
chembl id: CHEMBL_MEC_5278
has molecule: CHEMBL545315
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5277
type: Mechanism
chembl id: CHEMBL_MEC_5277
has molecule: CHEMBL545315
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5279
type: Mechanism
chembl id: CHEMBL_MEC_5279
has molecule: CHEMBL545315
has target: CHEMBL3009
mechanism description: Receptor protein-tyrosine kinase erbB-4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2001
type: Mechanism
chembl id: CHEMBL_MEC_2001
has molecule: CHEMBL1356607
has target: CHEMBL2331074
mechanism description: Adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1212
type: Mechanism
chembl id: CHEMBL_MEC_1212
has molecule: CHEMBL1370561
has target: CHEMBL2111329
mechanism description: Adenosine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1066
type: Mechanism
chembl id: CHEMBL_MEC_1066
has molecule: CHEMBL1370561
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1135
type: Mechanism
chembl id: CHEMBL_MEC_1135
has molecule: CHEMBL1370561
has target: CHEMBL2094125
mechanism description: Phosphodiesterase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1886
type: Mechanism
chembl id: CHEMBL_MEC_1886
has molecule: CHEMBL1417019
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_103
type: Mechanism
chembl id: CHEMBL_MEC_103
has molecule: CHEMBL1417019
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2363
type: Mechanism
chembl id: CHEMBL_MEC_2363
has molecule: CHEMBL1534525
has target: CHEMBL2362995
mechanism description: Voltage-gated T-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1649
type: Mechanism
chembl id: CHEMBL_MEC_1649
has molecule: CHEMBL1525826
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5599
type: Mechanism
chembl id: CHEMBL_MEC_5599
has molecule: CHEMBL515387
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_334
type: Mechanism
chembl id: CHEMBL_MEC_334
has molecule: CHEMBL1200349
has target: CHEMBL287
mechanism description: Sigma opioid receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_293
type: Mechanism
chembl id: CHEMBL_MEC_293
has molecule: CHEMBL1200970
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1735
type: Mechanism
chembl id: CHEMBL_MEC_1735
has molecule: CHEMBL1200344
has target: CHEMBL2362972
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2199
type: Mechanism
chembl id: CHEMBL_MEC_2199
has molecule: CHEMBL1200660
mechanism description: Unknown

CHEMBL_MEC_1277
type: Mechanism
chembl id: CHEMBL_MEC_1277
has molecule: CHEMBL1200805
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2115
type: Mechanism
chembl id: CHEMBL_MEC_2115
has molecule: CHEMBL1201481
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_637
type: Mechanism
chembl id: CHEMBL_MEC_637
has molecule: CHEMBL1201618
has target: CHEMBL1985
mechanism description: Glucagon receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1140
type: Mechanism
chembl id: CHEMBL_MEC_1140
has molecule: CHEMBL1200329
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_538
type: Mechanism
chembl id: CHEMBL_MEC_538
has molecule: CHEMBL1201656
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1718
type: Mechanism
chembl id: CHEMBL_MEC_1718
has molecule: CHEMBL1201005
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1793
type: Mechanism
chembl id: CHEMBL_MEC_1793
has molecule: CHEMBL1201608
has target: CHEMBL2364168
has binding site: CHEMBL BS 2656
mechanism description: T cell surface glycoprotein CD3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4648
type: Mechanism
chembl id: CHEMBL_MEC_4648
has molecule: CHEMBL1614701
has target: CHEMBL2964
mechanism description: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4647
type: Mechanism
chembl id: CHEMBL_MEC_4647
has molecule: CHEMBL1614701
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4384
type: Mechanism
chembl id: CHEMBL_MEC_4384
has molecule: CHEMBL1614707
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4299
type: Mechanism
chembl id: CHEMBL_MEC_4299
has molecule: CHEMBL1614710
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4300
type: Mechanism
chembl id: CHEMBL_MEC_4300
has molecule: CHEMBL1614710
has target: CHEMBL2095227
mechanism description: Vascular endothelial growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4685
type: Mechanism
chembl id: CHEMBL_MEC_4685
has molecule: CHEMBL1614713
has target: CHEMBL2276
mechanism description: c-Jun N-terminal kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4687
type: Mechanism
chembl id: CHEMBL_MEC_4687
has molecule: CHEMBL1614713
has target: CHEMBL2637
mechanism description: c-Jun N-terminal kinase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4686
type: Mechanism
chembl id: CHEMBL_MEC_4686
has molecule: CHEMBL1614713
has target: CHEMBL4179
mechanism description: c-Jun N-terminal kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2214
type: Mechanism
chembl id: CHEMBL_MEC_2214
has molecule: CHEMBL1615371
mechanism description: Unknown

CHEMBL_MEC_589
type: Mechanism
chembl id: CHEMBL_MEC_589
has molecule: CHEMBL1615372
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2022
type: Mechanism
chembl id: CHEMBL_MEC_2022
has molecule: CHEMBL1615372
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_403
type: Mechanism
chembl id: CHEMBL_MEC_403
has molecule: CHEMBL1615374
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_473
type: Mechanism
chembl id: CHEMBL_MEC_473
has molecule: CHEMBL1615374
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_1078
type: Mechanism
chembl id: CHEMBL_MEC_1078
has molecule: CHEMBL1174
has target: CHEMBL2093869
mechanism description: Integrin alpha-IIb/beta-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1468
type: Mechanism
chembl id: CHEMBL_MEC_1468
has molecule: CHEMBL152
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4938
type: Mechanism
chembl id: CHEMBL_MEC_4938
has molecule: CHEMBL392149
has target: CHEMBL226
mechanism description: Adenosine A1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4805
type: Mechanism
chembl id: CHEMBL_MEC_4805
has molecule: CHEMBL475251
has target: CHEMBL2599
mechanism description: Tyrosine-protein kinase SYK inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1308
type: Mechanism
chembl id: CHEMBL_MEC_1308
has molecule: CHEMBL1685
has target: CHEMBL237
mechanism description: Kappa opioid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_729
type: Mechanism
chembl id: CHEMBL_MEC_729
has molecule: CHEMBL1685
has target: CHEMBL233
mechanism description: Mu opioid receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_4128
type: Mechanism
chembl id: CHEMBL_MEC_4128
has molecule: CHEMBL574738
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4129
type: Mechanism
chembl id: CHEMBL_MEC_4129
has molecule: CHEMBL574738
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2096
type: Mechanism
chembl id: CHEMBL_MEC_2096
has molecule: CHEMBL797
has target: CHEMBL2362995
mechanism description: Voltage-gated T-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1802
type: Mechanism
chembl id: CHEMBL_MEC_1802
has molecule: CHEMBL1201557
has target: CHEMBL2364170
mechanism description: Interferon alpha/beta receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1082
type: Mechanism
chembl id: CHEMBL_MEC_1082
has molecule: CHEMBL1567328
has target: CHEMBL2095173
has binding site: CHEMBL BS 2651
mechanism description: Potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_747
type: Mechanism
chembl id: CHEMBL_MEC_747
has molecule: CHEMBL748
has target: CHEMBL220
mechanism description: Acetylcholinesterase activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_659
type: Mechanism
chembl id: CHEMBL_MEC_659
has molecule: CHEMBL1393
has target: CHEMBL1994
mechanism description: Mineralocorticoid receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4391
type: Mechanism
chembl id: CHEMBL_MEC_4391
has molecule: CHEMBL1615025
has target: CHEMBL2964
mechanism description: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4390
type: Mechanism
chembl id: CHEMBL_MEC_4390
has molecule: CHEMBL1615025
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4360
type: Mechanism
chembl id: CHEMBL_MEC_4360
has molecule: CHEMBL1614766
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4361
type: Mechanism
chembl id: CHEMBL_MEC_4361
has molecule: CHEMBL1614766
has target: CHEMBL2964
mechanism description: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_570
type: Mechanism
chembl id: CHEMBL_MEC_570
has molecule: CHEMBL1185
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_364
type: Mechanism
chembl id: CHEMBL_MEC_364
has molecule: CHEMBL1185
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5856
type: Mechanism
chembl id: CHEMBL_MEC_5856
has molecule: CHEMBL1615835
has target: CHEMBL3107
mechanism description: Basic fibroblast growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5866
type: Mechanism
chembl id: CHEMBL_MEC_5866
has molecule: CHEMBL1615835
has target: CHEMBL1783
mechanism description: Vascular endothelial growth factor A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5780
type: Mechanism
chembl id: CHEMBL_MEC_5780
has molecule: CHEMBL1615835
has target: CHEMBL3921
mechanism description: Heparanase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5865
type: Mechanism
chembl id: CHEMBL_MEC_5865
has molecule: CHEMBL1615835
has target: CHEMBL2120
mechanism description: Acidic fibroblast growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1196
type: Mechanism
chembl id: CHEMBL_MEC_1196
has molecule: CHEMBL15770
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1798
type: Mechanism
chembl id: CHEMBL_MEC_1798
has molecule: CHEMBL1201562
has target: CHEMBL2364170
mechanism description: Interferon alpha/beta receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1269
type: Mechanism
chembl id: CHEMBL_MEC_1269
has molecule: CHEMBL1237132
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2130
type: Mechanism
chembl id: CHEMBL_MEC_2130
has molecule: CHEMBL1593906
mechanism description: Unknown

CHEMBL_MEC_110
type: Mechanism
chembl id: CHEMBL_MEC_110
has molecule: CHEMBL1168
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1711
type: Mechanism
chembl id: CHEMBL_MEC_1711
has molecule: CHEMBL174
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1752
type: Mechanism
chembl id: CHEMBL_MEC_1752
has molecule: CHEMBL1164318
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1717
type: Mechanism
chembl id: CHEMBL_MEC_1717
has molecule: CHEMBL1200366
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1452
type: Mechanism
chembl id: CHEMBL_MEC_1452
has molecule: CHEMBL1200438
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1922
type: Mechanism
chembl id: CHEMBL_MEC_1922
has molecule: CHEMBL1628502
has target: CHEMBL2363032
has binding site: CHEMBL BS 2657
mechanism description: Voltage-gated calcium channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_832
type: Mechanism
chembl id: CHEMBL_MEC_832
has molecule: CHEMBL1628504
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_865
type: Mechanism
chembl id: CHEMBL_MEC_865
has molecule: CHEMBL1200980
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_881
type: Mechanism
chembl id: CHEMBL_MEC_881
has molecule: CHEMBL1628234
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_356
type: Mechanism
chembl id: CHEMBL_MEC_356
has molecule: CHEMBL1628240
has target: CHEMBL1877
mechanism description: Arabinosyltransferase A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_685
type: Mechanism
chembl id: CHEMBL_MEC_685
has molecule: CHEMBL1201192
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1769
type: Mechanism
chembl id: CHEMBL_MEC_1769
has molecule: CHEMBL1237086
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2068
type: Mechanism
chembl id: CHEMBL_MEC_2068
has molecule: CHEMBL564085
has target: CHEMBL2363853
has binding site: CHEMBL BS 2622
mechanism description: 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5139
type: Mechanism
chembl id: CHEMBL_MEC_5139
has molecule: CHEMBL1258006
has target: CHEMBL2492
mechanism description: Neuronal acetylcholine receptor protein alpha-7 subunit agonist
mechanism action type: AGONIST

CHEMBL_MEC_4101
type: Mechanism
chembl id: CHEMBL_MEC_4101
has molecule: CHEMBL1645462
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4102
type: Mechanism
chembl id: CHEMBL_MEC_4102
has molecule: CHEMBL1645462
has target: CHEMBL3009
mechanism description: Receptor protein-tyrosine kinase erbB-4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4100
type: Mechanism
chembl id: CHEMBL_MEC_4100
has molecule: CHEMBL1645462
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1848
type: Mechanism
chembl id: CHEMBL_MEC_1848
has molecule: CHEMBL1651906
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5134
type: Mechanism
chembl id: CHEMBL_MEC_5134
has molecule: CHEMBL1255840
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1646
type: Mechanism
chembl id: CHEMBL_MEC_1646
has molecule: CHEMBL1382627
has target: CHEMBL2364668
mechanism description: Bacterial dihydropteroate synthase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5081
type: Mechanism
chembl id: CHEMBL_MEC_5081
has molecule: CHEMBL419667
has target: CHEMBL2049
mechanism description: Oxytocin receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5080
type: Mechanism
chembl id: CHEMBL_MEC_5080
has molecule: CHEMBL419667
has target: CHEMBL1889
mechanism description: Vasopressin V1a receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2264
type: Mechanism
chembl id: CHEMBL_MEC_2264
has molecule: CHEMBL514800
has target: CHEMBL2093863
mechanism description: Phosphodiesterase 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4385
type: Mechanism
chembl id: CHEMBL_MEC_4385
has molecule: CHEMBL1614725
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4386
type: Mechanism
chembl id: CHEMBL_MEC_4386
has molecule: CHEMBL1614725
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1346
type: Mechanism
chembl id: CHEMBL_MEC_1346
has molecule: CHEMBL1789842
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5344
type: Mechanism
chembl id: CHEMBL_MEC_5344
has molecule: CHEMBL1628688
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1585
type: Mechanism
chembl id: CHEMBL_MEC_1585
has molecule: CHEMBL1751
has target: CHEMBL2095186
has binding site: CHEMBL BS 2653
mechanism description: Sodium/potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_799
type: Mechanism
chembl id: CHEMBL_MEC_799
has molecule: CHEMBL1200989
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5280
type: Mechanism
chembl id: CHEMBL_MEC_5280
has molecule: CHEMBL1078178
has target: CHEMBL2835
mechanism description: Tyrosine-protein kinase JAK1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5281
type: Mechanism
chembl id: CHEMBL_MEC_5281
has molecule: CHEMBL1078178
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5382
type: Mechanism
chembl id: CHEMBL_MEC_5382
has molecule: CHEMBL482950
has target: CHEMBL1800
mechanism description: Corticotropin releasing factor receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1283
type: Mechanism
chembl id: CHEMBL_MEC_1283
has molecule: CHEMBL218394
has target: CHEMBL2095231
mechanism description: Hepatitis C virus serine protease, NS3/NS4A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5175
type: Mechanism
chembl id: CHEMBL_MEC_5175
has molecule: CHEMBL1688243
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4877
type: Mechanism
chembl id: CHEMBL_MEC_4877
has molecule: CHEMBL1631540
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4878
type: Mechanism
chembl id: CHEMBL_MEC_4878
has molecule: CHEMBL1631540
has target: CHEMBL228
mechanism description: Serotonin transporter antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4875
type: Mechanism
chembl id: CHEMBL_MEC_4875
has molecule: CHEMBL1631540
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4876
type: Mechanism
chembl id: CHEMBL_MEC_4876
has molecule: CHEMBL1631540
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1674
type: Mechanism
chembl id: CHEMBL_MEC_1674
has molecule: CHEMBL1200945
has target: CHEMBL2366037
mechanism description: Radioactive metals chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1864
type: Mechanism
chembl id: CHEMBL_MEC_1864
has molecule: CHEMBL105
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_862
type: Mechanism
chembl id: CHEMBL_MEC_862
has molecule: CHEMBL691
has target: CHEMBL206
mechanism description: Estrogen receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_1632
type: Mechanism
chembl id: CHEMBL_MEC_1632
has molecule: CHEMBL1723343
has target: CHEMBL2111392
has binding site: CHEMBL BS 2619
mechanism description: GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_132
type: Mechanism
chembl id: CHEMBL_MEC_132
has molecule: CHEMBL1713082
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1407
type: Mechanism
chembl id: CHEMBL_MEC_1407
has molecule: CHEMBL1374379
has target: CHEMBL2364682
mechanism description: Slowly adapting pulmonary stretch receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1104
type: Mechanism
chembl id: CHEMBL_MEC_1104
has molecule: CHEMBL1683544
has target: CHEMBL2095182
has binding site: CHEMBL BS 2627
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1727
type: Mechanism
chembl id: CHEMBL_MEC_1727
has molecule: CHEMBL1697708
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4304
type: Mechanism
chembl id: CHEMBL_MEC_4304
has molecule: CHEMBL1684984
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4603
type: Mechanism
chembl id: CHEMBL_MEC_4603
has molecule: CHEMBL1716091
has target: CHEMBL2061
mechanism description: Retinoid X receptor alpha modulator
mechanism action type: MODULATOR

CHEMBL_MEC_4704
type: Mechanism
chembl id: CHEMBL_MEC_4704
has molecule: CHEMBL1738757
has target: CHEMBL1862
mechanism description: Tyrosine-protein kinase ABL inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5235
type: Mechanism
chembl id: CHEMBL_MEC_5235
has molecule: CHEMBL1762621
has target: CHEMBL235
mechanism description: Peroxisome proliferator-activated receptor gamma antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5237
type: Mechanism
chembl id: CHEMBL_MEC_5237
has molecule: CHEMBL1762621
has target: CHEMBL3038498
mechanism description: Keap1/Nrf2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5236
type: Mechanism
chembl id: CHEMBL_MEC_5236
has molecule: CHEMBL1762621
has target: CHEMBL1991
mechanism description: Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5079
type: Mechanism
chembl id: CHEMBL_MEC_5079
has molecule: CHEMBL10188
has target: CHEMBL4429
mechanism description: Neurokinin 3 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_433
type: Mechanism
chembl id: CHEMBL_MEC_433
has molecule: CHEMBL672
has target: CHEMBL239
mechanism description: Peroxisome proliferator-activated receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_623
type: Mechanism
chembl id: CHEMBL_MEC_623
has molecule: CHEMBL85
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_601
type: Mechanism
chembl id: CHEMBL_MEC_601
has molecule: CHEMBL85
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2012
type: Mechanism
chembl id: CHEMBL_MEC_2012
has molecule: CHEMBL85
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1207
type: Mechanism
chembl id: CHEMBL_MEC_1207
has molecule: CHEMBL956
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5698
type: Mechanism
chembl id: CHEMBL_MEC_5698
has molecule: CHEMBL1767407
has target: CHEMBL4398
mechanism description: Purinergic receptor P2Y2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1785
type: Mechanism
chembl id: CHEMBL_MEC_1785
has molecule: CHEMBL1275977
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1777
type: Mechanism
chembl id: CHEMBL_MEC_1777
has molecule: CHEMBL1607480
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_290
type: Mechanism
chembl id: CHEMBL_MEC_290
has molecule: CHEMBL1529
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_602
type: Mechanism
chembl id: CHEMBL_MEC_602
has molecule: CHEMBL54
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2026
type: Mechanism
chembl id: CHEMBL_MEC_2026
has molecule: CHEMBL54
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor inverse agonist
mechanism action type: INVERSE AGONIST

CHEMBL_MEC_13
type: Mechanism
chembl id: CHEMBL_MEC_13
has molecule: CHEMBL19
has target: CHEMBL2326
mechanism description: Carbonic anhydrase VII inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_957
type: Mechanism
chembl id: CHEMBL_MEC_957
has molecule: CHEMBL19
has target: CHEMBL3729
mechanism description: Carbonic anhydrase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_90
type: Mechanism
chembl id: CHEMBL_MEC_90
has molecule: CHEMBL19
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_18
type: Mechanism
chembl id: CHEMBL_MEC_18
has molecule: CHEMBL19
has target: CHEMBL261
mechanism description: Carbonic anhydrase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_144
type: Mechanism
chembl id: CHEMBL_MEC_144
has molecule: CHEMBL1719
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_169
type: Mechanism
chembl id: CHEMBL_MEC_169
has molecule: CHEMBL1564
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4337
type: Mechanism
chembl id: CHEMBL_MEC_4337
has molecule: CHEMBL1766582
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1030
type: Mechanism
chembl id: CHEMBL_MEC_1030
has molecule: CHEMBL473417
has target: CHEMBL5971
mechanism description: Smoothened homolog inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_847
type: Mechanism
chembl id: CHEMBL_MEC_847
has molecule: CHEMBL535396
has target: CHEMBL2052
mechanism description: Influenza virus A matrix protein M2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1109
type: Mechanism
chembl id: CHEMBL_MEC_1109
has molecule: CHEMBL538943
has target: CHEMBL2095182
has binding site: CHEMBL BS 2627
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5401
type: Mechanism
chembl id: CHEMBL_MEC_5401
has molecule: CHEMBL1742408
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1056
type: Mechanism
chembl id: CHEMBL_MEC_1056
has molecule: CHEMBL1744447
has target: CHEMBL402
mechanism description: HMG-CoA reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_775
type: Mechanism
chembl id: CHEMBL_MEC_775
has molecule: CHEMBL131
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2023
type: Mechanism
chembl id: CHEMBL_MEC_2023
has molecule: CHEMBL715
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_620
type: Mechanism
chembl id: CHEMBL_MEC_620
has molecule: CHEMBL715
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_594
type: Mechanism
chembl id: CHEMBL_MEC_594
has molecule: CHEMBL715
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1218
type: Mechanism
chembl id: CHEMBL_MEC_1218
has molecule: CHEMBL730
has target: CHEMBL2111348
has binding site: CHEMBL BS 2654
mechanism description: Soluble guanylate cyclase activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_4465
type: Mechanism
chembl id: CHEMBL_MEC_4465
has molecule: CHEMBL1672627
has target: CHEMBL255
mechanism description: Adenosine A2b receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5218
type: Mechanism
chembl id: CHEMBL_MEC_5218
has molecule: CHEMBL1738889
has target: CHEMBL1871
mechanism description: Androgen Receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_1052
type: Mechanism
chembl id: CHEMBL_MEC_1052
has molecule: CHEMBL503
has target: CHEMBL402
mechanism description: HMG-CoA reductase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5345
type: Mechanism
chembl id: CHEMBL_MEC_5345
has molecule: CHEMBL1668019
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1337
type: Mechanism
chembl id: CHEMBL_MEC_1337
has molecule: CHEMBL1084172
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1499
type: Mechanism
chembl id: CHEMBL_MEC_1499
has molecule: CHEMBL1735
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5443
type: Mechanism
chembl id: CHEMBL_MEC_5443
has molecule: CHEMBL1742981
has target: CHEMBL3580482
mechanism description: Mucin-16 other
mechanism action type: OTHER

CHEMBL_MEC_5978
type: Mechanism
chembl id: CHEMBL_MEC_5978
has molecule: CHEMBL1742983
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5979
type: Mechanism
chembl id: CHEMBL_MEC_5979
has molecule: CHEMBL1742984
has target: CHEMBL3712878
mechanism description: Mesothelin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5983
type: Mechanism
chembl id: CHEMBL_MEC_5983
has molecule: CHEMBL1742986
has target: CHEMBL3713436
mechanism description: Tumor necrosis factor ligand superfamily member 13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5982
type: Mechanism
chembl id: CHEMBL_MEC_5982
has molecule: CHEMBL1742986
has target: CHEMBL2364158
mechanism description: Tumor necrosis factor ligand superfamily member 13B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5867
type: Mechanism
chembl id: CHEMBL_MEC_5867
has molecule: CHEMBL1742986
has target: CHEMBL3713436
mechanism description: Tumor necrosis factor ligand superfamily member 13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5528
type: Mechanism
chembl id: CHEMBL_MEC_5528
has molecule: CHEMBL1742986
has target: CHEMBL2364158
mechanism description: Tumor necrosis factor ligand superfamily member 13B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5984
type: Mechanism
chembl id: CHEMBL_MEC_5984
has molecule: CHEMBL1742988
has target: CHEMBL3833421
mechanism description: Heterotrimeric lymphotoxin LTa1b2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5985
type: Mechanism
chembl id: CHEMBL_MEC_5985
has molecule: CHEMBL1742988
has target: CHEMBL3712914
mechanism description: Tumor necrosis factor ligand superfamily member 14 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5986
type: Mechanism
chembl id: CHEMBL_MEC_5986
has molecule: CHEMBL1742989
has target: CHEMBL3833422
mechanism description: Phosphatidylserine inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1410
type: Mechanism
chembl id: CHEMBL_MEC_1410
has molecule: CHEMBL1742990
has target: CHEMBL2364156
mechanism description: T-lymphocyte activation antigen CD86 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1413
type: Mechanism
chembl id: CHEMBL_MEC_1413
has molecule: CHEMBL1742990
has target: CHEMBL2364157
mechanism description: T-lymphocyte activation antigen CD80 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5444
type: Mechanism
chembl id: CHEMBL_MEC_5444
has molecule: CHEMBL1742991
has target: CHEMBL3580483
mechanism description: Interleukin-5 receptor subunit alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2322
type: Mechanism
chembl id: CHEMBL_MEC_2322
has molecule: CHEMBL1742992
has target: CHEMBL2364168
mechanism description: T cell surface glycoprotein CD3 cross-linking agent
mechanism action type: CROSS-LINKING AGENT

CHEMBL_MEC_2323
type: Mechanism
chembl id: CHEMBL_MEC_2323
has molecule: CHEMBL1742992
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 cross-linking agent
mechanism action type: CROSS-LINKING AGENT

CHEMBL_MEC_5955
type: Mechanism
chembl id: CHEMBL_MEC_5955
has molecule: CHEMBL1742993
has target: CHEMBL3580487
mechanism description: Sclerostin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1101
type: Mechanism
chembl id: CHEMBL_MEC_1101
has molecule: CHEMBL1742994
has target: CHEMBL2095182
has binding site: CHEMBL BS 2627
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1419
type: Mechanism
chembl id: CHEMBL_MEC_1419
has molecule: CHEMBL1742994
has target: CHEMBL2364161
mechanism description: Tumor necrosis factor receptor superfamily member 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5448
type: Mechanism
chembl id: CHEMBL_MEC_5448
has molecule: CHEMBL1742996
has target: CHEMBL3580485
mechanism description: Interleukin-17 receptor A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5987
type: Mechanism
chembl id: CHEMBL_MEC_5987
has molecule: CHEMBL1742997
has target: CHEMBL3580494
mechanism description: Mucin-1 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_5988
type: Mechanism
chembl id: CHEMBL_MEC_5988
has molecule: CHEMBL1742998
has target: CHEMBL3580494
mechanism description: Mucin-1 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_5989
type: Mechanism
chembl id: CHEMBL_MEC_5989
has molecule: CHEMBL1742999
has target: CHEMBL1649052
mechanism description: C-C motif chemokine 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5956
type: Mechanism
chembl id: CHEMBL_MEC_5956
has molecule: CHEMBL1743000
has target: CHEMBL3580493
mechanism description: Epithelial cell adhesion molecule binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_5990
type: Mechanism
chembl id: CHEMBL_MEC_5990
has molecule: CHEMBL1743001
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5991
type: Mechanism
chembl id: CHEMBL_MEC_5991
has molecule: CHEMBL1743003
has target: CHEMBL1075153
mechanism description: Tumor necrosis factor receptor superfamily member 10B agonist
mechanism action type: AGONIST

CHEMBL_MEC_5993
type: Mechanism
chembl id: CHEMBL_MEC_5993
has molecule: CHEMBL1743005
has target: CHEMBL1250358
mechanism description: Tumor necrosis factor receptor superfamily member 5 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5995
type: Mechanism
chembl id: CHEMBL_MEC_5995
has molecule: CHEMBL1743008
has target: CHEMBL1075153
mechanism description: Tumor necrosis factor receptor superfamily member 10B agonist
mechanism action type: AGONIST

CHEMBL_MEC_5449
type: Mechanism
chembl id: CHEMBL_MEC_5449
has molecule: CHEMBL1743009
has target: CHEMBL3580503
mechanism description: Heat shock protein 90 homolog inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5957
type: Mechanism
chembl id: CHEMBL_MEC_5957
has molecule: CHEMBL1743011
has target: CHEMBL3712850
mechanism description: Tumor necrosis factor receptor superfamily member 12A agonist
mechanism action type: AGONIST

CHEMBL_MEC_5996
type: Mechanism
chembl id: CHEMBL_MEC_5996
has molecule: CHEMBL1743012
has target: CHEMBL3712932
mechanism description: Interleukin-9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5958
type: Mechanism
chembl id: CHEMBL_MEC_5958
has molecule: CHEMBL1743013
has target: CHEMBL3713020
mechanism description: Mucin-5AC other
mechanism action type: OTHER

CHEMBL_MEC_5450
type: Mechanism
chembl id: CHEMBL_MEC_5450
has molecule: CHEMBL1743015
has target: CHEMBL2979
mechanism description: Integrin beta-7 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5451
type: Mechanism
chembl id: CHEMBL_MEC_5451
has molecule: CHEMBL1743016
has target: CHEMBL2121
mechanism description: Folate receptor alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5998
type: Mechanism
chembl id: CHEMBL_MEC_5998
has molecule: CHEMBL1743017
has target: CHEMBL3712915
mechanism description: Interleukin-22 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5999
type: Mechanism
chembl id: CHEMBL_MEC_5999
has molecule: CHEMBL1743018
has target: CHEMBL5479
mechanism description: Hepatocyte growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5452
type: Mechanism
chembl id: CHEMBL_MEC_5452
has molecule: CHEMBL1743019
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6002
type: Mechanism
chembl id: CHEMBL_MEC_6002
has molecule: CHEMBL1743022
has target: CHEMBL3712903
mechanism description: Transforming growth factor beta-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6001
type: Mechanism
chembl id: CHEMBL_MEC_6001
has molecule: CHEMBL1743022
has target: CHEMBL3217393
mechanism description: Transforming growth factor beta-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6000
type: Mechanism
chembl id: CHEMBL_MEC_6000
has molecule: CHEMBL1743022
has target: CHEMBL1795178
mechanism description: Transforming growth factor beta-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5453
type: Mechanism
chembl id: CHEMBL_MEC_5453
has molecule: CHEMBL1743023
has target: CHEMBL1649058
mechanism description: Beta-nerve growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5454
type: Mechanism
chembl id: CHEMBL_MEC_5454
has molecule: CHEMBL1743024
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5456
type: Mechanism
chembl id: CHEMBL_MEC_5456
has molecule: CHEMBL1743026
has target: CHEMBL1909490
mechanism description: Interleukin-1 beta negative allosteric modulator
mechanism action type: NEGATIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5457
type: Mechanism
chembl id: CHEMBL_MEC_5457
has molecule: CHEMBL1743027
has target: CHEMBL3594
mechanism description: Carbonic anhydrase IX other
mechanism action type: OTHER

CHEMBL_MEC_6003
type: Mechanism
chembl id: CHEMBL_MEC_6003
has molecule: CHEMBL1743028
has target: CHEMBL3712919
mechanism description: Transmembrane glycoprotein NMB binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_6004
type: Mechanism
chembl id: CHEMBL_MEC_6004
has molecule: CHEMBL1743029
has target: CHEMBL2754
mechanism description: T-cell surface antigen CD4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5458
type: Mechanism
chembl id: CHEMBL_MEC_5458
has molecule: CHEMBL1743035
has target: CHEMBL3580486
mechanism description: Interleukin-13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5459
type: Mechanism
chembl id: CHEMBL_MEC_5459
has molecule: CHEMBL1743042
has target: CHEMBL2364165
mechanism description: Fusion glycoprotein F0 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5460
type: Mechanism
chembl id: CHEMBL_MEC_5460
has molecule: CHEMBL1743043
has target: CHEMBL3218
mechanism description: CD22 other
mechanism action type: OTHER

CHEMBL_MEC_2427
type: Mechanism
chembl id: CHEMBL_MEC_2427
has molecule: CHEMBL1743047
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2241
type: Mechanism
chembl id: CHEMBL_MEC_2241
has molecule: CHEMBL1743048
has target: CHEMBL2058
mechanism description: B-lymphocyte antigen CD20 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6014
type: Mechanism
chembl id: CHEMBL_MEC_6014
has molecule: CHEMBL1743049
has target: CHEMBL2007
mechanism description: Platelet-derived growth factor receptor alpha antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6015
type: Mechanism
chembl id: CHEMBL_MEC_6015
has molecule: CHEMBL1743050
has target: CHEMBL1795129
mechanism description: Interleukin-6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6016
type: Mechanism
chembl id: CHEMBL_MEC_6016
has molecule: CHEMBL1743052
has target: CHEMBL3580493
mechanism description: Epithelial cell adhesion molecule binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_5462
type: Mechanism
chembl id: CHEMBL_MEC_5462
has molecule: CHEMBL1743053
has target: CHEMBL1975
mechanism description: T-cell surface glycoprotein CD3 epsilon chain other
mechanism action type: OTHER

CHEMBL_MEC_6018
type: Mechanism
chembl id: CHEMBL_MEC_6018
has molecule: CHEMBL1743056
has target: CHEMBL2059
mechanism description: TNF-beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6020
type: Mechanism
chembl id: CHEMBL_MEC_6020
has molecule: CHEMBL1743058
has target: CHEMBL2487
mechanism description: Beta amyloid A4 protein other
mechanism action type: OTHER

CHEMBL_MEC_1245
type: Mechanism
chembl id: CHEMBL_MEC_1245
has molecule: CHEMBL1481
has target: CHEMBL2096972
mechanism description: Sulfonylurea receptor 1, Kir6.2 blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2039
type: Mechanism
chembl id: CHEMBL_MEC_2039
has molecule: CHEMBL1863515
has target: CHEMBL2364710
mechanism description: Methotrexate hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_5343
type: Mechanism
chembl id: CHEMBL_MEC_5343
has molecule: CHEMBL1208155
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2273
type: Mechanism
chembl id: CHEMBL_MEC_2273
has molecule: CHEMBL1743062
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5463
type: Mechanism
chembl id: CHEMBL_MEC_5463
has molecule: CHEMBL1743063
has target: CHEMBL5479
mechanism description: Hepatocyte growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6021
type: Mechanism
chembl id: CHEMBL_MEC_6021
has molecule: CHEMBL1743064
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6022
type: Mechanism
chembl id: CHEMBL_MEC_6022
has molecule: CHEMBL1743065
has target: CHEMBL3712996
mechanism description: Blood group Rh(D) polypeptide inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6023
type: Mechanism
chembl id: CHEMBL_MEC_6023
has molecule: CHEMBL1743067
has target: CHEMBL3712870
mechanism description: OX-2 membrane glycoprotein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2327
type: Mechanism
chembl id: CHEMBL_MEC_2327
has molecule: CHEMBL1743068
has target: CHEMBL3390822
mechanism description: Interleukin 17A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2274
type: Mechanism
chembl id: CHEMBL_MEC_2274
has molecule: CHEMBL1743070
has target: CHEMBL1795129
mechanism description: Interleukin-6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5464
type: Mechanism
chembl id: CHEMBL_MEC_5464
has molecule: CHEMBL1743071
has target: CHEMBL1795129
mechanism description: Interleukin-6 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6024
type: Mechanism
chembl id: CHEMBL_MEC_6024
has molecule: CHEMBL1743073
has target: CHEMBL3588735
mechanism description: Inhibin beta A chain inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5466
type: Mechanism
chembl id: CHEMBL_MEC_5466
has molecule: CHEMBL1743075
has target: CHEMBL2364158
mechanism description: Tumor necrosis factor ligand superfamily member 13B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6026
type: Mechanism
chembl id: CHEMBL_MEC_6026
has molecule: CHEMBL1743077
has target: CHEMBL3712856
mechanism description: Tenascin other
mechanism action type: OTHER

CHEMBL_MEC_5467
type: Mechanism
chembl id: CHEMBL_MEC_5467
has molecule: CHEMBL1743078
has target: CHEMBL1975
mechanism description: T-cell surface glycoprotein CD3 epsilon chain other
mechanism action type: OTHER

CHEMBL_MEC_5977
type: Mechanism
chembl id: CHEMBL_MEC_5977
has molecule: CHEMBL1743079
has target: CHEMBL1957
mechanism description: Insulin-like growth factor I receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5468
type: Mechanism
chembl id: CHEMBL_MEC_5468
has molecule: CHEMBL1743080
has target: CHEMBL1075153
mechanism description: Tumor necrosis factor receptor superfamily member 10B agonist
mechanism action type: AGONIST

CHEMBL_MEC_5469
type: Mechanism
chembl id: CHEMBL_MEC_5469
has molecule: CHEMBL1743081
has target: CHEMBL3580486
mechanism description: Interleukin-13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6027
type: Mechanism
chembl id: CHEMBL_MEC_6027
has molecule: CHEMBL1743083
has target: CHEMBL2754
mechanism description: T-cell surface antigen CD4 agonist
mechanism action type: AGONIST

CHEMBL_MEC_6028
type: Mechanism
chembl id: CHEMBL_MEC_6028
has molecule: CHEMBL1743085
has target: CHEMBL3712857
mechanism description: Tumor necrosis factor receptor superfamily member 9 agonist
mechanism action type: AGONIST

CHEMBL_MEC_6029
type: Mechanism
chembl id: CHEMBL_MEC_6029
has molecule: CHEMBL1743086
has target: CHEMBL4998
mechanism description: Integrin alpha-2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6030
type: Mechanism
chembl id: CHEMBL_MEC_6030
has molecule: CHEMBL1743088
has target: CHEMBL2058
mechanism description: B-lymphocyte antigen CD20 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4504
type: Mechanism
chembl id: CHEMBL_MEC_4504
has molecule: CHEMBL1783256
has target: CHEMBL4956
mechanism description: GABA receptor alpha-2 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_4505
type: Mechanism
chembl id: CHEMBL_MEC_4505
has molecule: CHEMBL1783256
has target: CHEMBL3026
mechanism description: GABA receptor alpha-3 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5120
type: Mechanism
chembl id: CHEMBL_MEC_5120
has molecule: CHEMBL1783282
has target: CHEMBL3026
mechanism description: GABA receptor alpha-3 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5119
type: Mechanism
chembl id: CHEMBL_MEC_5119
has molecule: CHEMBL1783282
has target: CHEMBL4956
mechanism description: GABA receptor alpha-2 subunit positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5370
type: Mechanism
chembl id: CHEMBL_MEC_5370
has molecule: CHEMBL220360
has target: CHEMBL218
mechanism description: Cannabinoid CB1 receptor inverse agonist
mechanism action type: INVERSE AGONIST

CHEMBL_MEC_2268
type: Mechanism
chembl id: CHEMBL_MEC_2268
has molecule: CHEMBL125
mechanism description: Unknown

CHEMBL_MEC_523
type: Mechanism
chembl id: CHEMBL_MEC_523
has molecule: CHEMBL1399
has target: CHEMBL1978
mechanism description: Cytochrome P450 19A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1414
type: Mechanism
chembl id: CHEMBL_MEC_1414
has molecule: CHEMBL1789843
has target: CHEMBL2364158
mechanism description: Tumor necrosis factor ligand superfamily member 13B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1422
type: Mechanism
chembl id: CHEMBL_MEC_1422
has molecule: CHEMBL1789844
has target: CHEMBL2364164
mechanism description: Cytotoxic T-lymphocyte protein 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4519
type: Mechanism
chembl id: CHEMBL_MEC_4519
has molecule: CHEMBL561132
has target: CHEMBL5071
mechanism description: G protein-coupled receptor 44 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_672
type: Mechanism
chembl id: CHEMBL_MEC_672
has molecule: CHEMBL1286
has target: CHEMBL1998
mechanism description: Synaptic vesicle glycoprotein 2A modulator
mechanism action type: MODULATOR

CHEMBL_MEC_990
type: Mechanism
chembl id: CHEMBL_MEC_990
has molecule: CHEMBL1286
has target: CHEMBL4478
mechanism description: Voltage-gated N-type calcium channel alpha-1B subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_965
type: Mechanism
chembl id: CHEMBL_MEC_965
has molecule: CHEMBL2010601
has target: CHEMBL4051
mechanism description: Cystic fibrosis transmembrane conductance regulator positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_354
type: Mechanism
chembl id: CHEMBL_MEC_354
has molecule: CHEMBL1055
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1492
type: Mechanism
chembl id: CHEMBL_MEC_1492
has molecule: CHEMBL1205
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5380
type: Mechanism
chembl id: CHEMBL_MEC_5380
has molecule: CHEMBL414157
has target: CHEMBL226
mechanism description: Adenosine A1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1167
type: Mechanism
chembl id: CHEMBL_MEC_1167
has molecule: CHEMBL1200339
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_29
type: Mechanism
chembl id: CHEMBL_MEC_29
has molecule: CHEMBL1578
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_279
type: Mechanism
chembl id: CHEMBL_MEC_279
has molecule: CHEMBL1578
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1344
type: Mechanism
chembl id: CHEMBL_MEC_1344
has molecule: CHEMBL1082607
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_57
type: Mechanism
chembl id: CHEMBL_MEC_57
has molecule: CHEMBL1742982
has target: CHEMBL1783
mechanism description: Vascular endothelial growth factor A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1035
type: Mechanism
chembl id: CHEMBL_MEC_1035
has molecule: CHEMBL1742982
has target: CHEMBL1697671
mechanism description: Placenta growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4691
type: Mechanism
chembl id: CHEMBL_MEC_4691
has molecule: CHEMBL105442
has target: CHEMBL3587
mechanism description: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4692
type: Mechanism
chembl id: CHEMBL_MEC_4692
has molecule: CHEMBL105442
has target: CHEMBL2964
mechanism description: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5171
type: Mechanism
chembl id: CHEMBL_MEC_5171
has molecule: CHEMBL604710
has target: CHEMBL4478
mechanism description: Voltage-gated N-type calcium channel alpha-1B subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2167
type: Mechanism
chembl id: CHEMBL_MEC_2167
has molecule: CHEMBL1006
mechanism description: Reactive metabolite scavenging agent

CHEMBL_MEC_5391
type: Mechanism
chembl id: CHEMBL_MEC_5391
has molecule: CHEMBL74355
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1176
type: Mechanism
chembl id: CHEMBL_MEC_1176
has molecule: CHEMBL1034
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_353
type: Mechanism
chembl id: CHEMBL_MEC_353
has molecule: CHEMBL1054
has target: CHEMBL1876
mechanism description: Thiazide-sensitive sodium-chloride cotransporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_497
type: Mechanism
chembl id: CHEMBL_MEC_497
has molecule: CHEMBL960
has target: CHEMBL1966
mechanism description: Dihydroorotate dehydrogenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1764
type: Mechanism
chembl id: CHEMBL_MEC_1764
has molecule: CHEMBL376140
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_524
type: Mechanism
chembl id: CHEMBL_MEC_524
has molecule: CHEMBL1444
has target: CHEMBL1978
mechanism description: Cytochrome P450 19A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1871
type: Mechanism
chembl id: CHEMBL_MEC_1871
has molecule: CHEMBL1475
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4765
type: Mechanism
chembl id: CHEMBL_MEC_4765
has molecule: CHEMBL1079175
has target: CHEMBL2111353
mechanism description: Serine/threonine-protein kinase AKT inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4165
type: Mechanism
chembl id: CHEMBL_MEC_4165
has molecule: CHEMBL296468
has target: CHEMBL3055
mechanism description: Cyclin-dependent kinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4164
type: Mechanism
chembl id: CHEMBL_MEC_4164
has molecule: CHEMBL296468
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4166
type: Mechanism
chembl id: CHEMBL_MEC_4166
has molecule: CHEMBL296468
has target: CHEMBL3116
mechanism description: Cyclin-dependent kinase 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_161
type: Mechanism
chembl id: CHEMBL_MEC_161
has molecule: CHEMBL1172
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1606
type: Mechanism
chembl id: CHEMBL_MEC_1606
has molecule: CHEMBL2068724
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_1127
type: Mechanism
chembl id: CHEMBL_MEC_1127
has molecule: CHEMBL2068724
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_217
type: Mechanism
chembl id: CHEMBL_MEC_217
has molecule: CHEMBL1201445
has target: CHEMBL1832
mechanism description: Calcitonin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1787
type: Mechanism
chembl id: CHEMBL_MEC_1787
has molecule: CHEMBL1741
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4109
type: Mechanism
chembl id: CHEMBL_MEC_4109
has molecule: CHEMBL585902
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_171
type: Mechanism
chembl id: CHEMBL_MEC_171
has molecule: CHEMBL1200403
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_39
type: Mechanism
chembl id: CHEMBL_MEC_39
has molecule: CHEMBL1200473
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1028
type: Mechanism
chembl id: CHEMBL_MEC_1028
has molecule: CHEMBL1479
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1333
type: Mechanism
chembl id: CHEMBL_MEC_1333
has molecule: CHEMBL1479
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1324
type: Mechanism
chembl id: CHEMBL_MEC_1324
has molecule: CHEMBL1170
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1816
type: Mechanism
chembl id: CHEMBL_MEC_1816
has molecule: CHEMBL1289
has target: CHEMBL2364033
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1715
type: Mechanism
chembl id: CHEMBL_MEC_1715
has molecule: CHEMBL1200356
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1596
type: Mechanism
chembl id: CHEMBL_MEC_1596
has molecule: CHEMBL70418
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1598
type: Mechanism
chembl id: CHEMBL_MEC_1598
has molecule: CHEMBL646
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_5593
type: Mechanism
chembl id: CHEMBL_MEC_5593
has molecule: CHEMBL481611
has target: CHEMBL268
mechanism description: Cathepsin K inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2174
type: Mechanism
chembl id: CHEMBL_MEC_2174
has molecule: CHEMBL1863513
mechanism description: Unknown

CHEMBL_MEC_2228
type: Mechanism
chembl id: CHEMBL_MEC_2228
has molecule: CHEMBL1863514
has target: CHEMBL2364706
mechanism description: Asparagine hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_5026
type: Mechanism
chembl id: CHEMBL_MEC_5026
has molecule: CHEMBL592435
has target: CHEMBL226
mechanism description: Adenosine A1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_27
type: Mechanism
chembl id: CHEMBL_MEC_27
has molecule: CHEMBL1200479
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_285
type: Mechanism
chembl id: CHEMBL_MEC_285
has molecule: CHEMBL1200479
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_784
type: Mechanism
chembl id: CHEMBL_MEC_784
has molecule: CHEMBL1200500
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_868
type: Mechanism
chembl id: CHEMBL_MEC_868
has molecule: CHEMBL1200749
has target: CHEMBL2072
mechanism description: Sodium channel protein type IV alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1025
type: Mechanism
chembl id: CHEMBL_MEC_1025
has molecule: CHEMBL1200624
has target: CHEMBL208
mechanism description: Progesterone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_159
type: Mechanism
chembl id: CHEMBL_MEC_159
has molecule: CHEMBL1200769
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_635
type: Mechanism
chembl id: CHEMBL_MEC_635
has molecule: CHEMBL1201060
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2021
type: Mechanism
chembl id: CHEMBL_MEC_2021
has molecule: CHEMBL1201060
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_587
type: Mechanism
chembl id: CHEMBL_MEC_587
has molecule: CHEMBL1201060
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1779
type: Mechanism
chembl id: CHEMBL_MEC_1779
has molecule: CHEMBL1200881
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1644
type: Mechanism
chembl id: CHEMBL_MEC_1644
has molecule: CHEMBL1200690
has target: CHEMBL2363078
mechanism description: Vasopressin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_310
type: Mechanism
chembl id: CHEMBL_MEC_310
has molecule: CHEMBL1200837
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1454
type: Mechanism
chembl id: CHEMBL_MEC_1454
has molecule: CHEMBL1200725
has target: CHEMBL1780
mechanism description: Cytochrome P450 51 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2223
type: Mechanism
chembl id: CHEMBL_MEC_2223
has molecule: CHEMBL1200851
mechanism description: Unknown

CHEMBL_MEC_917
type: Mechanism
chembl id: CHEMBL_MEC_917
has molecule: CHEMBL1200695
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_240
type: Mechanism
chembl id: CHEMBL_MEC_240
has molecule: CHEMBL1200695
has target: CHEMBL229
mechanism description: Alpha-1a adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_99
type: Mechanism
chembl id: CHEMBL_MEC_99
has molecule: CHEMBL1200645
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5767
type: Mechanism
chembl id: CHEMBL_MEC_5767
has molecule: CHEMBL1812161
has target: CHEMBL3623
mechanism description: Quinone reductase 1 modulator
mechanism action type: MODULATOR

CHEMBL_MEC_590
type: Mechanism
chembl id: CHEMBL_MEC_590
has molecule: CHEMBL1201052
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_208
type: Mechanism
chembl id: CHEMBL_MEC_208
has molecule: CHEMBL1201052
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_88
type: Mechanism
chembl id: CHEMBL_MEC_88
has molecule: CHEMBL1201162
has target: CHEMBL205
mechanism description: Carbonic anhydrase II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_443
type: Mechanism
chembl id: CHEMBL_MEC_443
has molecule: CHEMBL1200772
has target: CHEMBL1930
mechanism description: Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_14
type: Mechanism
chembl id: CHEMBL_MEC_14
has molecule: CHEMBL1201117
has target: CHEMBL261
mechanism description: Carbonic anhydrase I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1097
type: Mechanism
chembl id: CHEMBL_MEC_1097
has molecule: CHEMBL1201152
has target: CHEMBL2095181
mechanism description: Opioid receptors; mu/kappa/delta antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_934
type: Mechanism
chembl id: CHEMBL_MEC_934
has molecule: CHEMBL1795071
has target: CHEMBL2835
mechanism description: Tyrosine-protein kinase JAK1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_936
type: Mechanism
chembl id: CHEMBL_MEC_936
has molecule: CHEMBL1795071
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5619
type: Mechanism
chembl id: CHEMBL_MEC_5619
has molecule: CHEMBL552212
has target: CHEMBL2095182
mechanism description: Tubulin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1933
type: Mechanism
chembl id: CHEMBL_MEC_1933
has molecule: CHEMBL1448
has target: CHEMBL2366044
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1931
type: Mechanism
chembl id: CHEMBL_MEC_1931
has molecule: CHEMBL1448
has target: CHEMBL2366043
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2213
type: Mechanism
chembl id: CHEMBL_MEC_2213
has molecule: CHEMBL1201171
mechanism description: Unknown

CHEMBL_MEC_903
type: Mechanism
chembl id: CHEMBL_MEC_903
has molecule: CHEMBL1200900
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_138
type: Mechanism
chembl id: CHEMBL_MEC_138
has molecule: CHEMBL1200638
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_797
type: Mechanism
chembl id: CHEMBL_MEC_797
has molecule: CHEMBL1200562
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1500
type: Mechanism
chembl id: CHEMBL_MEC_1500
has molecule: CHEMBL1200678
has target: CHEMBL243
mechanism description: Human immunodeficiency virus type 1 protease inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_200
type: Mechanism
chembl id: CHEMBL_MEC_200
has molecule: CHEMBL1200854
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2004
type: Mechanism
chembl id: CHEMBL_MEC_2004
has molecule: CHEMBL1200503
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1695
type: Mechanism
chembl id: CHEMBL_MEC_1695
has molecule: CHEMBL1200530
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1509
type: Mechanism
chembl id: CHEMBL_MEC_1509
has molecule: CHEMBL1200935
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_34
type: Mechanism
chembl id: CHEMBL_MEC_34
has molecule: CHEMBL1200935
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_191
type: Mechanism
chembl id: CHEMBL_MEC_191
has molecule: CHEMBL1201074
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1783
type: Mechanism
chembl id: CHEMBL_MEC_1783
has molecule: CHEMBL532
has target: CHEMBL2363135
has binding site: CHEMBL BS 2621
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5094
type: Mechanism
chembl id: CHEMBL_MEC_5094
has molecule: CHEMBL1817709
has target: CHEMBL1889
mechanism description: Vasopressin V1a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1754
type: Mechanism
chembl id: CHEMBL_MEC_1754
has molecule: CHEMBL2068727
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_697
type: Mechanism
chembl id: CHEMBL_MEC_697
has molecule: CHEMBL1693
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_895
type: Mechanism
chembl id: CHEMBL_MEC_895
has molecule: CHEMBL1693
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_563
type: Mechanism
chembl id: CHEMBL_MEC_563
has molecule: CHEMBL2068726
has target: CHEMBL1982
mechanism description: Isoleucyl-tRNA synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1670
type: Mechanism
chembl id: CHEMBL_MEC_1670
has molecule: CHEMBL2068726
has target: CHEMBL2364671
mechanism description: Isoleucyl-tRNA synthetase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5997
type: Mechanism
chembl id: CHEMBL_MEC_5997
has molecule: CHEMBL1743014
has target: CHEMBL1907598
mechanism description: Integrin alpha-V/beta-3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5039
type: Mechanism
chembl id: CHEMBL_MEC_5039
has molecule: CHEMBL1779046
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5419
type: Mechanism
chembl id: CHEMBL_MEC_5419
has molecule: CHEMBL596802
has target: CHEMBL217
mechanism description: Dopamine D2 receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_2102
type: Mechanism
chembl id: CHEMBL_MEC_2102
has molecule: CHEMBL284348
has target: CHEMBL2362996
mechanism description: Voltage-gated potassium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_118
type: Mechanism
chembl id: CHEMBL_MEC_118
has molecule: CHEMBL1200831
has target: CHEMBL1808
mechanism description: Angiotensin-converting enzyme inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2015
type: Mechanism
chembl id: CHEMBL_MEC_2015
has molecule: CHEMBL1200411
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1146
type: Mechanism
chembl id: CHEMBL_MEC_1146
has molecule: CHEMBL1200379
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_718
type: Mechanism
chembl id: CHEMBL_MEC_718
has molecule: CHEMBL1200825
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1736
type: Mechanism
chembl id: CHEMBL_MEC_1736
has molecule: CHEMBL693
has target: CHEMBL2362972
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_379
type: Mechanism
chembl id: CHEMBL_MEC_379
has molecule: CHEMBL1200885
has target: CHEMBL1899
mechanism description: Serotonin 3a (5-HT3a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_40
type: Mechanism
chembl id: CHEMBL_MEC_40
has molecule: CHEMBL1184
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 agonist
mechanism action type: AGONIST

CHEMBL_MEC_278
type: Mechanism
chembl id: CHEMBL_MEC_278
has molecule: CHEMBL1724
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_24
type: Mechanism
chembl id: CHEMBL_MEC_24
has molecule: CHEMBL1724
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_263
type: Mechanism
chembl id: CHEMBL_MEC_263
has molecule: CHEMBL1200554
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_713
type: Mechanism
chembl id: CHEMBL_MEC_713
has molecule: CHEMBL1200890
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1084
type: Mechanism
chembl id: CHEMBL_MEC_1084
has molecule: CHEMBL1200408
has target: CHEMBL2095173
has binding site: CHEMBL BS 2651
mechanism description: Potassium-transporting ATPase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1235
type: Mechanism
chembl id: CHEMBL_MEC_1235
has molecule: CHEMBL1200413
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_296
type: Mechanism
chembl id: CHEMBL_MEC_296
has molecule: CHEMBL1200383
has target: CHEMBL216
mechanism description: Muscarinic acetylcholine receptor M1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1200
type: Mechanism
chembl id: CHEMBL_MEC_1200
has molecule: CHEMBL1200463
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2171
type: Mechanism
chembl id: CHEMBL_MEC_2171
has molecule: CHEMBL1200375
mechanism description: Unknown

CHEMBL_MEC_914
type: Mechanism
chembl id: CHEMBL_MEC_914
has molecule: CHEMBL1200395
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1126
type: Mechanism
chembl id: CHEMBL_MEC_1126
has molecule: CHEMBL1200395
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1980
type: Mechanism
chembl id: CHEMBL_MEC_1980
has molecule: CHEMBL1200395
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_177
type: Mechanism
chembl id: CHEMBL_MEC_177
has molecule: CHEMBL1200395
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1432
type: Mechanism
chembl id: CHEMBL_MEC_1432
has molecule: CHEMBL1201131
has target: CHEMBL2364702
mechanism description: Cytochrome P450 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_172
type: Mechanism
chembl id: CHEMBL_MEC_172
has molecule: CHEMBL1200406
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_322
type: Mechanism
chembl id: CHEMBL_MEC_322
has molecule: CHEMBL1200363
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1357
type: Mechanism
chembl id: CHEMBL_MEC_1357
has molecule: CHEMBL1200363
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1339
type: Mechanism
chembl id: CHEMBL_MEC_1339
has molecule: CHEMBL1200444
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1807
type: Mechanism
chembl id: CHEMBL_MEC_1807
has molecule: CHEMBL1201073
has target: CHEMBL2364029
mechanism description: Lead chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_1817
type: Mechanism
chembl id: CHEMBL_MEC_1817
has molecule: CHEMBL1200647
has target: CHEMBL2364035
mechanism description: Cell membrane inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_195
type: Mechanism
chembl id: CHEMBL_MEC_195
has molecule: CHEMBL1200707
has target: CHEMBL217
mechanism description: Dopamine D2 receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_158
type: Mechanism
chembl id: CHEMBL_MEC_158
has molecule: CHEMBL1200450
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2046
type: Mechanism
chembl id: CHEMBL_MEC_2046
has molecule: CHEMBL1200393
has target: CHEMBL2363033
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1910
type: Mechanism
chembl id: CHEMBL_MEC_1910
has molecule: CHEMBL1200393
has target: CHEMBL2311225
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1401
type: Mechanism
chembl id: CHEMBL_MEC_1401
has molecule: CHEMBL1200397
has target: CHEMBL2364679
mechanism description: Squalene monooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1938
type: Mechanism
chembl id: CHEMBL_MEC_1938
has molecule: CHEMBL1201042
has target: CHEMBL2366048
mechanism description: ATP inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_598
type: Mechanism
chembl id: CHEMBL_MEC_598
has molecule: CHEMBL1200469
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2014
type: Mechanism
chembl id: CHEMBL_MEC_2014
has molecule: CHEMBL1200469
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1278
type: Mechanism
chembl id: CHEMBL_MEC_1278
has molecule: CHEMBL1200402
has target: CHEMBL2095229
mechanism description: Voltage-gated L-type calcium channel blocker
mechanism action type: BLOCKER

CHEMBL_MEC_1613
type: Mechanism
chembl id: CHEMBL_MEC_1613
has molecule: CHEMBL1200420
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_762
type: Mechanism
chembl id: CHEMBL_MEC_762
has molecule: CHEMBL1201173
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1237
type: Mechanism
chembl id: CHEMBL_MEC_1237
has molecule: CHEMBL1200791
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha agonist
mechanism action type: AGONIST

CHEMBL_MEC_785
type: Mechanism
chembl id: CHEMBL_MEC_785
has molecule: CHEMBL1200545
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1239
type: Mechanism
chembl id: CHEMBL_MEC_1239
has molecule: CHEMBL1200787
has target: CHEMBL2095203
mechanism description: Adrenergic receptor alpha antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_193
type: Mechanism
chembl id: CHEMBL_MEC_193
has molecule: CHEMBL1200951
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1772
type: Mechanism
chembl id: CHEMBL_MEC_1772
has molecule: CHEMBL1200872
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1603
type: Mechanism
chembl id: CHEMBL_MEC_1603
has molecule: CHEMBL1200802
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_807
type: Mechanism
chembl id: CHEMBL_MEC_807
has molecule: CHEMBL1200975
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1310
type: Mechanism
chembl id: CHEMBL_MEC_1310
has molecule: CHEMBL1201047
has target: CHEMBL237
mechanism description: Kappa opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_728
type: Mechanism
chembl id: CHEMBL_MEC_728
has molecule: CHEMBL1201047
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_466
type: Mechanism
chembl id: CHEMBL_MEC_466
has molecule: CHEMBL1201174
has target: CHEMBL284
mechanism description: Dipeptidyl peptidase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_829
type: Mechanism
chembl id: CHEMBL_MEC_829
has molecule: CHEMBL1200619
has target: CHEMBL247
mechanism description: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_892
type: Mechanism
chembl id: CHEMBL_MEC_892
has molecule: CHEMBL1200782
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_694
type: Mechanism
chembl id: CHEMBL_MEC_694
has molecule: CHEMBL1200782
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1485
type: Mechanism
chembl id: CHEMBL_MEC_1485
has molecule: CHEMBL1200782
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_395
type: Mechanism
chembl id: CHEMBL_MEC_395
has molecule: CHEMBL1200322
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_818
type: Mechanism
chembl id: CHEMBL_MEC_818
has molecule: CHEMBL1200953
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_761
type: Mechanism
chembl id: CHEMBL_MEC_761
has molecule: CHEMBL1200845
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_380
type: Mechanism
chembl id: CHEMBL_MEC_380
has molecule: CHEMBL1200940
has target: CHEMBL1899
mechanism description: Serotonin 3a (5-HT3a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_209
type: Mechanism
chembl id: CHEMBL_MEC_209
has molecule: CHEMBL1200940
has target: CHEMBL217
mechanism description: Dopamine D2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1336
type: Mechanism
chembl id: CHEMBL_MEC_1336
has molecule: CHEMBL1200940
has target: CHEMBL1875
mechanism description: Serotonin 4 (5-HT4) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1697
type: Mechanism
chembl id: CHEMBL_MEC_1697
has molecule: CHEMBL1201019
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_782
type: Mechanism
chembl id: CHEMBL_MEC_782
has molecule: CHEMBL1201109
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2161
type: Mechanism
chembl id: CHEMBL_MEC_2161
has molecule: CHEMBL1200680
mechanism description: Unknown

CHEMBL_MEC_1477
type: Mechanism
chembl id: CHEMBL_MEC_1477
has molecule: CHEMBL1201110
has target: CHEMBL1872
mechanism description: Human herpesvirus 1 DNA polymerase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1988
type: Mechanism
chembl id: CHEMBL_MEC_1988
has molecule: CHEMBL1200586
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2146
type: Mechanism
chembl id: CHEMBL_MEC_2146
has molecule: CHEMBL1201015
mechanism description: Unknown

CHEMBL_MEC_33
type: Mechanism
chembl id: CHEMBL_MEC_33
has molecule: CHEMBL1200803
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1505
type: Mechanism
chembl id: CHEMBL_MEC_1505
has molecule: CHEMBL1200803
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1526
type: Mechanism
chembl id: CHEMBL_MEC_1526
has molecule: CHEMBL1201116
has target: CHEMBL2362973
mechanism description: Penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_709
type: Mechanism
chembl id: CHEMBL_MEC_709
has molecule: CHEMBL1200599
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1831
type: Mechanism
chembl id: CHEMBL_MEC_1831
has molecule: CHEMBL1201000
has target: CHEMBL2364041
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_698
type: Mechanism
chembl id: CHEMBL_MEC_698
has molecule: CHEMBL1201178
has target: CHEMBL238
mechanism description: Dopamine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_1487
type: Mechanism
chembl id: CHEMBL_MEC_1487
has molecule: CHEMBL1201178
has target: CHEMBL1893
mechanism description: Synaptic vesicular amine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_920
type: Mechanism
chembl id: CHEMBL_MEC_920
has molecule: CHEMBL1201178
has target: CHEMBL222
mechanism description: Norepinephrine transporter releasing agent
mechanism action type: RELEASING AGENT

CHEMBL_MEC_333
type: Mechanism
chembl id: CHEMBL_MEC_333
has molecule: CHEMBL1200327
has target: CHEMBL287
mechanism description: Sigma opioid receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_463
type: Mechanism
chembl id: CHEMBL_MEC_463
has molecule: CHEMBL1200988
has target: CHEMBL1941
mechanism description: Histamine H2 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1186
type: Mechanism
chembl id: CHEMBL_MEC_1186
has molecule: CHEMBL1200990
has target: CHEMBL2094253
mechanism description: Cyclooxygenase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_381
type: Mechanism
chembl id: CHEMBL_MEC_381
has molecule: CHEMBL1200755
has target: CHEMBL1901
mechanism description: Cholecystokinin A receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1328
type: Mechanism
chembl id: CHEMBL_MEC_1328
has molecule: CHEMBL1201101
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1626
type: Mechanism
chembl id: CHEMBL_MEC_1626
has molecule: CHEMBL1200602
has target: CHEMBL2093872
has binding site: CHEMBL BS 2617
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_726
type: Mechanism
chembl id: CHEMBL_MEC_726
has molecule: CHEMBL1200817
has target: CHEMBL233
mechanism description: Mu opioid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1381
type: Mechanism
chembl id: CHEMBL_MEC_1381
has molecule: CHEMBL1200977
has target: CHEMBL241
mechanism description: Phosphodiesterase 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_152
type: Mechanism
chembl id: CHEMBL_MEC_152
has molecule: CHEMBL1201068
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_105
type: Mechanism
chembl id: CHEMBL_MEC_105
has molecule: CHEMBL1200976
has target: CHEMBL1806
mechanism description: DNA topoisomerase II alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1889
type: Mechanism
chembl id: CHEMBL_MEC_1889
has molecule: CHEMBL1200976
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_314
type: Mechanism
chembl id: CHEMBL_MEC_314
has molecule: CHEMBL1200708
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1746
type: Mechanism
chembl id: CHEMBL_MEC_1746
has molecule: CHEMBL1200400
has target: CHEMBL2362992
mechanism description: Amidophosphoribosyltransferase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1875
type: Mechanism
chembl id: CHEMBL_MEC_1875
has molecule: CHEMBL1200400
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_976
type: Mechanism
chembl id: CHEMBL_MEC_976
has molecule: CHEMBL1795072
has target: CHEMBL4478
mechanism description: Voltage-gated N-type calcium channel alpha-1B subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_60
type: Mechanism
chembl id: CHEMBL_MEC_60
has molecule: CHEMBL414357
has target: CHEMBL1784
mechanism description: Glucagon-like peptide 1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4663
type: Mechanism
chembl id: CHEMBL_MEC_4663
has molecule: CHEMBL1879463
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4662
type: Mechanism
chembl id: CHEMBL_MEC_4662
has molecule: CHEMBL1879463
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_795
type: Mechanism
chembl id: CHEMBL_MEC_795
has molecule: CHEMBL1200376
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_627
type: Mechanism
chembl id: CHEMBL_MEC_627
has molecule: CHEMBL1710
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_610
type: Mechanism
chembl id: CHEMBL_MEC_610
has molecule: CHEMBL1710
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2028
type: Mechanism
chembl id: CHEMBL_MEC_2028
has molecule: CHEMBL1710
has target: CHEMBL2331075
mechanism description: D2-like dopamine receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1969
type: Mechanism
chembl id: CHEMBL_MEC_1969
has molecule: CHEMBL1200443
has target: CHEMBL2331043
mechanism description: Sodium channel alpha subunit blocker
mechanism action type: BLOCKER

CHEMBL_MEC_5826
type: Mechanism
chembl id: CHEMBL_MEC_5826
has molecule: CHEMBL1808388
has target: CHEMBL3884
mechanism description: Sodium/glucose cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5819
type: Mechanism
chembl id: CHEMBL_MEC_5819
has molecule: CHEMBL1808388
has target: CHEMBL3884
mechanism description: Sodium/glucose cotransporter 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_919
type: Mechanism
chembl id: CHEMBL_MEC_919
has molecule: CHEMBL1692
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_410
type: Mechanism
chembl id: CHEMBL_MEC_410
has molecule: CHEMBL1692
has target: CHEMBL228
mechanism description: Serotonin transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4456
type: Mechanism
chembl id: CHEMBL_MEC_4456
has molecule: CHEMBL1915540
has target: CHEMBL3759
mechanism description: Histamine H4 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4991
type: Mechanism
chembl id: CHEMBL_MEC_4991
has molecule: CHEMBL1910936
has target: CHEMBL3798
mechanism description: Calcitonin gene-related peptide type 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1768
type: Mechanism
chembl id: CHEMBL_MEC_1768
has molecule: CHEMBL454950
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5512
type: Mechanism
chembl id: CHEMBL_MEC_5512
has molecule: CHEMBL607400
has target: CHEMBL1998
mechanism description: Synaptic vesicle glycoprotein 2A modulator
mechanism action type: MODULATOR

CHEMBL_MEC_2342
type: Mechanism
chembl id: CHEMBL_MEC_2342
has molecule: CHEMBL1097279
has target: CHEMBL2001
mechanism description: Purinergic receptor P2Y12 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5241
type: Mechanism
chembl id: CHEMBL_MEC_5241
has molecule: CHEMBL1908391
has target: CHEMBL2742
mechanism description: Fibroblast growth factor receptor 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5243
type: Mechanism
chembl id: CHEMBL_MEC_5243
has molecule: CHEMBL1908391
has target: CHEMBL2095189
mechanism description: Platelet-derived growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5242
type: Mechanism
chembl id: CHEMBL_MEC_5242
has molecule: CHEMBL1908391
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4226
type: Mechanism
chembl id: CHEMBL_MEC_4226
has molecule: CHEMBL1908394
has target: CHEMBL3024
mechanism description: Serine/threonine-protein kinase PLK1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1625
type: Mechanism
chembl id: CHEMBL_MEC_1625
has molecule: CHEMBL681
has target: CHEMBL2093872
mechanism description: GABA-A receptor; anion channel positive modulator
mechanism action type: POSITIVE MODULATOR

CHEMBL_MEC_4135
type: Mechanism
chembl id: CHEMBL_MEC_4135
has molecule: CHEMBL1969664
has target: CHEMBL2095188
mechanism description: Glycogen synthase kinase-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4981
type: Mechanism
chembl id: CHEMBL_MEC_4981
has molecule: CHEMBL1914489
has target: CHEMBL5071
mechanism description: G protein-coupled receptor 44 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5679
type: Mechanism
chembl id: CHEMBL_MEC_5679
has molecule: CHEMBL1921976
has target: CHEMBL3522
mechanism description: Cytochrome P450 17A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_188
type: Mechanism
chembl id: CHEMBL_MEC_188
has molecule: CHEMBL1963681
has target: CHEMBL1827
mechanism description: Phosphodiesterase 5A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_641
type: Mechanism
chembl id: CHEMBL_MEC_641
has molecule: CHEMBL1963683
has target: CHEMBL1987
mechanism description: Prostanoid FP receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_123
type: Mechanism
chembl id: CHEMBL_MEC_123
has molecule: CHEMBL1963684
has target: CHEMBL1817
mechanism description: Erythropoietin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2112
type: Mechanism
chembl id: CHEMBL_MEC_2112
has molecule: CHEMBL1963685
mechanism description: Surfactant agent

CHEMBL_MEC_2079
type: Mechanism
chembl id: CHEMBL_MEC_2079
has molecule: CHEMBL1964120
has target: CHEMBL2364176
mechanism description: Glucocerebroside hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_4881
type: Mechanism
chembl id: CHEMBL_MEC_4881
has molecule: CHEMBL1940832
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5021
type: Mechanism
chembl id: CHEMBL_MEC_5021
has molecule: CHEMBL1950553
has target: CHEMBL251
mechanism description: Adenosine A2a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5350
type: Mechanism
chembl id: CHEMBL_MEC_5350
has molecule: CHEMBL1950554
has target: CHEMBL251
mechanism description: Adenosine A2a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4688
type: Mechanism
chembl id: CHEMBL_MEC_4688
has molecule: CHEMBL1950289
has target: CHEMBL2276
mechanism description: c-Jun N-terminal kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4689
type: Mechanism
chembl id: CHEMBL_MEC_4689
has molecule: CHEMBL1950289
has target: CHEMBL4179
mechanism description: c-Jun N-terminal kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4690
type: Mechanism
chembl id: CHEMBL_MEC_4690
has molecule: CHEMBL1950289
has target: CHEMBL2637
mechanism description: c-Jun N-terminal kinase 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5351
type: Mechanism
chembl id: CHEMBL_MEC_5351
has molecule: CHEMBL1950649
has target: CHEMBL251
mechanism description: Adenosine A2a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4882
type: Mechanism
chembl id: CHEMBL_MEC_4882
has molecule: CHEMBL1950651
has target: CHEMBL251
mechanism description: Adenosine A2a receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1856
type: Mechanism
chembl id: CHEMBL_MEC_1856
has molecule: CHEMBL1488
has target: CHEMBL2311221
mechanism description: DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2196
type: Mechanism
chembl id: CHEMBL_MEC_2196
has molecule: CHEMBL1200972
mechanism description: Unknown

CHEMBL_MEC_4378
type: Mechanism
chembl id: CHEMBL_MEC_4378
has molecule: CHEMBL1952329
has target: CHEMBL3559682
mechanism description: Serine/threonine-protein kinase PIM inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4313
type: Mechanism
chembl id: CHEMBL_MEC_4313
has molecule: CHEMBL1938400
has target: CHEMBL260
mechanism description: MAP kinase p38 alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1775
type: Mechanism
chembl id: CHEMBL_MEC_1775
has molecule: CHEMBL261772
has target: CHEMBL2363135
has binding site: CHEMBL BS 2620
mechanism description: Bacterial 70S ribosome inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4431
type: Mechanism
chembl id: CHEMBL_MEC_4431
has molecule: CHEMBL1829335
has target: CHEMBL264
mechanism description: Histamine H3 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4148
type: Mechanism
chembl id: CHEMBL_MEC_4148
has molecule: CHEMBL2041933
has target: CHEMBL4630
mechanism description: Serine/threonine-protein kinase Chk1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1699
type: Mechanism
chembl id: CHEMBL_MEC_1699
has molecule: CHEMBL1200523
has target: CHEMBL2354204
mechanism description: Bacterial penicillin-binding protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_978
type: Mechanism
chembl id: CHEMBL_MEC_978
has molecule: CHEMBL1200699
has target: CHEMBL4588
mechanism description: Matrix metalloproteinase 8 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_987
type: Mechanism
chembl id: CHEMBL_MEC_987
has molecule: CHEMBL1200699
has target: CHEMBL332
mechanism description: Matrix metalloproteinase-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_966
type: Mechanism
chembl id: CHEMBL_MEC_966
has molecule: CHEMBL1200699
has target: CHEMBL4073
mechanism description: Matrix metalloproteinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_981
type: Mechanism
chembl id: CHEMBL_MEC_981
has molecule: CHEMBL1200699
has target: CHEMBL280
mechanism description: Matrix metalloproteinase 13 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4809
type: Mechanism
chembl id: CHEMBL_MEC_4809
has molecule: CHEMBL1922094
has target: CHEMBL2842
mechanism description: Serine/threonine-protein kinase mTOR inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4810
type: Mechanism
chembl id: CHEMBL_MEC_4810
has molecule: CHEMBL1922094
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5181
type: Mechanism
chembl id: CHEMBL_MEC_5181
has molecule: CHEMBL2023349
has target: CHEMBL4895
mechanism description: Tyrosine-protein kinase receptor UFO inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_384
type: Mechanism
chembl id: CHEMBL_MEC_384
has molecule: CHEMBL1908360
has target: CHEMBL1902
mechanism description: FK506-binding protein 1A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2339
type: Mechanism
chembl id: CHEMBL_MEC_2339
has molecule: CHEMBL1908370
has target: CHEMBL3390828
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2337
type: Mechanism
chembl id: CHEMBL_MEC_2337
has molecule: CHEMBL1908370
has target: CHEMBL3390827
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2338
type: Mechanism
chembl id: CHEMBL_MEC_2338
has molecule: CHEMBL1908370
has target: CHEMBL3038482
mechanism description: DNA gyrase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2336
type: Mechanism
chembl id: CHEMBL_MEC_2336
has molecule: CHEMBL1908370
has target: CHEMBL3038508
mechanism description: Topoisomerase IV inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5638
type: Mechanism
chembl id: CHEMBL_MEC_5638
has molecule: CHEMBL1908371
has target: CHEMBL244
mechanism description: Coagulation factor X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4581
type: Mechanism
chembl id: CHEMBL_MEC_4581
has molecule: CHEMBL1908373
has target: CHEMBL208
mechanism description: Progesterone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5239
type: Mechanism
chembl id: CHEMBL_MEC_5239
has molecule: CHEMBL1908376
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4642
type: Mechanism
chembl id: CHEMBL_MEC_4642
has molecule: CHEMBL1976040
has target: CHEMBL5491
mechanism description: Serine/threonine-protein kinase WEE1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5173
type: Mechanism
chembl id: CHEMBL_MEC_5173
has molecule: CHEMBL1951575
has target: CHEMBL4427
mechanism description: Prostanoid DP receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5174
type: Mechanism
chembl id: CHEMBL_MEC_5174
has molecule: CHEMBL1951575
has target: CHEMBL5071
mechanism description: G protein-coupled receptor 44 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4980
type: Mechanism
chembl id: CHEMBL_MEC_4980
has molecule: CHEMBL1951914
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4122
type: Mechanism
chembl id: CHEMBL_MEC_4122
has molecule: CHEMBL1967878
has target: CHEMBL3430911
mechanism description: Serine/threonine-protein kinase Aurora inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1290
type: Mechanism
chembl id: CHEMBL_MEC_1290
has molecule: CHEMBL1569
has target: CHEMBL1932894
mechanism description: Matrix protein 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1128
type: Mechanism
chembl id: CHEMBL_MEC_1128
has molecule: CHEMBL1569
has target: CHEMBL2094124
mechanism description: Glutamate [NMDA] receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_319
type: Mechanism
chembl id: CHEMBL_MEC_319
has molecule: CHEMBL1557
has target: CHEMBL213
mechanism description: Beta-1 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4668
type: Mechanism
chembl id: CHEMBL_MEC_4668
has molecule: CHEMBL2017974
has target: CHEMBL3559703
mechanism description: PI3-kinase class I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5130
type: Mechanism
chembl id: CHEMBL_MEC_5130
has molecule: CHEMBL2068839
has target: CHEMBL1907603
mechanism description: Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4886
type: Mechanism
chembl id: CHEMBL_MEC_4886
has molecule: CHEMBL2037511
has target: CHEMBL2049
mechanism description: Oxytocin receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4398
type: Mechanism
chembl id: CHEMBL_MEC_4398
has molecule: CHEMBL1944698
has target: CHEMBL308
mechanism description: Cyclin-dependent kinase 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4403
type: Mechanism
chembl id: CHEMBL_MEC_4403
has molecule: CHEMBL1944698
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4401
type: Mechanism
chembl id: CHEMBL_MEC_4401
has molecule: CHEMBL1944698
has target: CHEMBL3116
mechanism description: Cyclin-dependent kinase 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4399
type: Mechanism
chembl id: CHEMBL_MEC_4399
has molecule: CHEMBL1944698
has target: CHEMBL301
mechanism description: Cyclin-dependent kinase 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4400
type: Mechanism
chembl id: CHEMBL_MEC_4400
has molecule: CHEMBL1944698
has target: CHEMBL3055
mechanism description: Cyclin-dependent kinase 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4402
type: Mechanism
chembl id: CHEMBL_MEC_4402
has molecule: CHEMBL1944698
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4178
type: Mechanism
chembl id: CHEMBL_MEC_4178
has molecule: CHEMBL2029988
has target: CHEMBL5145
mechanism description: Serine/threonine-protein kinase B-raf inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4180
type: Mechanism
chembl id: CHEMBL_MEC_4180
has molecule: CHEMBL2029988
has target: CHEMBL2041
mechanism description: Tyrosine-protein kinase receptor RET inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4179
type: Mechanism
chembl id: CHEMBL_MEC_4179
has molecule: CHEMBL2029988
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5759
type: Mechanism
chembl id: CHEMBL_MEC_5759
has molecule: CHEMBL1829174
has target: CHEMBL4422
mechanism description: Free fatty acid receptor 1 positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_701
type: Mechanism
chembl id: CHEMBL_MEC_701
has molecule: CHEMBL1898523
has target: CHEMBL238
mechanism description: Dopamine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_916
type: Mechanism
chembl id: CHEMBL_MEC_916
has molecule: CHEMBL1898523
has target: CHEMBL222
mechanism description: Norepinephrine transporter inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5622
type: Mechanism
chembl id: CHEMBL_MEC_5622
has molecule: CHEMBL2017179
has target: CHEMBL3572
mechanism description: Cholesteryl ester transfer protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5037
type: Mechanism
chembl id: CHEMBL_MEC_5037
has molecule: CHEMBL2016681
has target: CHEMBL4561
mechanism description: Neuropeptide Y receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5051
type: Mechanism
chembl id: CHEMBL_MEC_5051
has molecule: CHEMBL2027925
has target: CHEMBL1875
mechanism description: Serotonin 4 (5-HT4) receptor partial agonist
mechanism action type: PARTIAL AGONIST

CHEMBL_MEC_4320
type: Mechanism
chembl id: CHEMBL_MEC_4320
has molecule: CHEMBL1963502
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1003
type: Mechanism
chembl id: CHEMBL_MEC_1003
has molecule: CHEMBL1669
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1256
type: Mechanism
chembl id: CHEMBL_MEC_1256
has molecule: CHEMBL1398126
has target: CHEMBL2107836
has binding site: CHEMBL BS 2634
mechanism description: Amiloride-sensitive sodium channel, ENaC blocker
mechanism action type: BLOCKER

CHEMBL_MEC_2105
type: Mechanism
chembl id: CHEMBL_MEC_2105
has molecule: CHEMBL2021423
mechanism description: Unknown

CHEMBL_MEC_2205
type: Mechanism
chembl id: CHEMBL_MEC_2205
has molecule: CHEMBL2021424
mechanism description: Unknown

CHEMBL_MEC_1581
type: Mechanism
chembl id: CHEMBL_MEC_1581
has molecule: CHEMBL2040681
has target: CHEMBL2364023
mechanism description: Nicotinic acetylcholine receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_809
type: Mechanism
chembl id: CHEMBL_MEC_809
has molecule: CHEMBL2040682
has target: CHEMBL2034
mechanism description: Glucocorticoid receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5238
type: Mechanism
chembl id: CHEMBL_MEC_5238
has molecule: CHEMBL2035874
has target: CHEMBL1947
mechanism description: Thyroid hormone receptor beta-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_5329
type: Mechanism
chembl id: CHEMBL_MEC_5329
has molecule: CHEMBL2035187
has target: CHEMBL1974
mechanism description: Tyrosine-protein kinase receptor FLT3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5328
type: Mechanism
chembl id: CHEMBL_MEC_5328
has molecule: CHEMBL2035187
has target: CHEMBL2971
mechanism description: Tyrosine-protein kinase JAK2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6057
type: Mechanism
chembl id: CHEMBL_MEC_6057
has molecule: CHEMBL2108739
has target: CHEMBL1825
mechanism description: TNF-alpha inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1927
type: Mechanism
chembl id: CHEMBL_MEC_1927
has molecule: CHEMBL2108888
has target: CHEMBL2366040
mechanism description: Globotriosylceramide hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_6124
type: Mechanism
chembl id: CHEMBL_MEC_6124
has molecule: CHEMBL2109487
has target: CHEMBL5378
mechanism description: P-selectin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6125
type: Mechanism
chembl id: CHEMBL_MEC_6125
has molecule: CHEMBL2109498
has target: CHEMBL3833441
mechanism description: Killer cell immunoglobulin-like receptor 2DL2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6126
type: Mechanism
chembl id: CHEMBL_MEC_6126
has molecule: CHEMBL2109498
has target: CHEMBL3713026
mechanism description: Killer cell immunoglobulin-like receptor 2DL3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6127
type: Mechanism
chembl id: CHEMBL_MEC_6127
has molecule: CHEMBL2109498
has target: CHEMBL3712912
mechanism description: Killer cell immunoglobulin-like receptor 2DL1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6129
type: Mechanism
chembl id: CHEMBL_MEC_6129
has molecule: CHEMBL2109500
has target: CHEMBL3833441
mechanism description: Killer cell immunoglobulin-like receptor 2DL2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6130
type: Mechanism
chembl id: CHEMBL_MEC_6130
has molecule: CHEMBL2109500
has target: CHEMBL3713026
mechanism description: Killer cell immunoglobulin-like receptor 2DL3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6128
type: Mechanism
chembl id: CHEMBL_MEC_6128
has molecule: CHEMBL2109500
has target: CHEMBL3712912
mechanism description: Killer cell immunoglobulin-like receptor 2DL1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6131
type: Mechanism
chembl id: CHEMBL_MEC_6131
has molecule: CHEMBL2109511
has target: CHEMBL4467
mechanism description: Mucosal addressin cell adhesion molecule-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6132
type: Mechanism
chembl id: CHEMBL_MEC_6132
has molecule: CHEMBL2109520
has target: CHEMBL1842
mechanism description: Myeloid cell surface antigen CD33 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_6134
type: Mechanism
chembl id: CHEMBL_MEC_6134
has molecule: CHEMBL2109528
has target: CHEMBL1649058
mechanism description: Beta-nerve growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6135
type: Mechanism
chembl id: CHEMBL_MEC_6135
has molecule: CHEMBL2109530
has target: CHEMBL1741309
mechanism description: Osteopontin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6136
type: Mechanism
chembl id: CHEMBL_MEC_6136
has molecule: CHEMBL2109539
has target: CHEMBL2929
mechanism description: Subtilisin/kexin type 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2401
type: Mechanism
chembl id: CHEMBL_MEC_2401
has molecule: CHEMBL2109540
has target: CHEMBL2929
mechanism description: Subtilisin/kexin type 9 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6137
type: Mechanism
chembl id: CHEMBL_MEC_6137
has molecule: CHEMBL2109544
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6138
type: Mechanism
chembl id: CHEMBL_MEC_6138
has molecule: CHEMBL2109555
has target: CHEMBL1892
mechanism description: Glutamate carboxypeptidase II other
mechanism action type: OTHER

CHEMBL_MEC_6139
type: Mechanism
chembl id: CHEMBL_MEC_6139
has molecule: CHEMBL2109562
has target: CHEMBL3712869
mechanism description: Parathyroid hormone-related protein inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6142
type: Mechanism
chembl id: CHEMBL_MEC_6142
has molecule: CHEMBL2109583
has target: CHEMBL3712856
mechanism description: Tenascin other
mechanism action type: OTHER

CHEMBL_MEC_2318
type: Mechanism
chembl id: CHEMBL_MEC_2318
has molecule: CHEMBL2105682
has target: CHEMBL244
mechanism description: Coagulation factor X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1323
type: Mechanism
chembl id: CHEMBL_MEC_1323
has molecule: CHEMBL2079587
has target: CHEMBL1871
mechanism description: Androgen Receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4658
type: Mechanism
chembl id: CHEMBL_MEC_4658
has molecule: CHEMBL2079588
has target: CHEMBL1955
mechanism description: Vascular endothelial growth factor receptor 3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4657
type: Mechanism
chembl id: CHEMBL_MEC_4657
has molecule: CHEMBL2079588
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4655
type: Mechanism
chembl id: CHEMBL_MEC_4655
has molecule: CHEMBL2079588
has target: CHEMBL1936
mechanism description: Stem cell growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4656
type: Mechanism
chembl id: CHEMBL_MEC_4656
has molecule: CHEMBL2079588
has target: CHEMBL1913
mechanism description: Platelet-derived growth factor receptor beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_4607
type: Mechanism
chembl id: CHEMBL_MEC_4607
has molecule: CHEMBL2104955
has target: CHEMBL1977
mechanism description: Vitamin D receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4908
type: Mechanism
chembl id: CHEMBL_MEC_4908
has molecule: CHEMBL2106698
has target: CHEMBL1983
mechanism description: Serotonin 1d (5-HT1d) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4907
type: Mechanism
chembl id: CHEMBL_MEC_4907
has molecule: CHEMBL2106698
has target: CHEMBL1898
mechanism description: Serotonin 1b (5-HT1b) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5313
type: Mechanism
chembl id: CHEMBL_MEC_5313
has molecule: CHEMBL2105719
has target: CHEMBL3009
mechanism description: Receptor protein-tyrosine kinase erbB-4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5312
type: Mechanism
chembl id: CHEMBL_MEC_5312
has molecule: CHEMBL2105719
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5311
type: Mechanism
chembl id: CHEMBL_MEC_5311
has molecule: CHEMBL2105719
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5075
type: Mechanism
chembl id: CHEMBL_MEC_5075
has molecule: CHEMBL1742420
has target: CHEMBL3911
mechanism description: Leukotriene B4 receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5201
type: Mechanism
chembl id: CHEMBL_MEC_5201
has molecule: CHEMBL2105631
mechanism description: Unknown

CHEMBL_MEC_5092
type: Mechanism
chembl id: CHEMBL_MEC_5092
has molecule: CHEMBL2105635
has target: CHEMBL3798
mechanism description: Calcitonin gene-related peptide type 1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5093
type: Mechanism
chembl id: CHEMBL_MEC_5093
has molecule: CHEMBL2105635
has target: CHEMBL2111189
mechanism description: Amylin receptor AMY1, CALCR/RAMP1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_5385
type: Mechanism
chembl id: CHEMBL_MEC_5385
has molecule: CHEMBL2106068
has target: CHEMBL252
mechanism description: Endothelin receptor ET-A antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4602
type: Mechanism
chembl id: CHEMBL_MEC_4602
has molecule: CHEMBL2105648
has target: CHEMBL2003
mechanism description: Retinoic acid receptor gamma agonist
mechanism action type: AGONIST

CHEMBL_MEC_5183
type: Mechanism
chembl id: CHEMBL_MEC_5183
has molecule: CHEMBL2109256
has target: CHEMBL2364161
mechanism description: Tumor necrosis factor receptor superfamily member 8 agonist
mechanism action type: AGONIST

CHEMBL_MEC_6068
type: Mechanism
chembl id: CHEMBL_MEC_6068
has molecule: CHEMBL2109263
has target: CHEMBL3580493
mechanism description: Epithelial cell adhesion molecule other
mechanism action type: OTHER

CHEMBL_MEC_6069
type: Mechanism
chembl id: CHEMBL_MEC_6069
has molecule: CHEMBL2109267
has target: CHEMBL1842
mechanism description: Myeloid cell surface antigen CD33 other
mechanism action type: OTHER

CHEMBL_MEC_6070
type: Mechanism
chembl id: CHEMBL_MEC_6070
has molecule: CHEMBL2109271
has target: CHEMBL5349
mechanism description: High affinity immunoglobulin gamma Fc receptor I other
mechanism action type: OTHER

CHEMBL_MEC_6071
type: Mechanism
chembl id: CHEMBL_MEC_6071
has molecule: CHEMBL2109271
has target: CHEMBL1824
mechanism description: Receptor protein-tyrosine kinase erbB-2 other
mechanism action type: OTHER

CHEMBL_MEC_6072
type: Mechanism
chembl id: CHEMBL_MEC_6072
has molecule: CHEMBL2109286
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_4784
type: Mechanism
chembl id: CHEMBL_MEC_4784
has molecule: CHEMBL2109295
has target: CHEMBL5311
mechanism description: Serine/threonine-protein kinase receptor R3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6073
type: Mechanism
chembl id: CHEMBL_MEC_6073
has molecule: CHEMBL2109300
has target: CHEMBL2487
mechanism description: Beta amyloid A4 protein other
mechanism action type: OTHER

CHEMBL_MEC_6074
type: Mechanism
chembl id: CHEMBL_MEC_6074
has molecule: CHEMBL2109308
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_6075
type: Mechanism
chembl id: CHEMBL_MEC_6075
has molecule: CHEMBL2109321
has target: CHEMBL3712885
mechanism description: Endoglin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6077
type: Mechanism
chembl id: CHEMBL_MEC_6077
has molecule: CHEMBL2109330
has target: CHEMBL2384897
mechanism description: Monocyte differentiation antigen CD14 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6076
type: Mechanism
chembl id: CHEMBL_MEC_6076
has molecule: CHEMBL2109332
has target: CHEMBL3631
mechanism description: Integrin beta-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5972
type: Mechanism
chembl id: CHEMBL_MEC_5972
has molecule: CHEMBL2109334
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 other
mechanism action type: OTHER

CHEMBL_MEC_6078
type: Mechanism
chembl id: CHEMBL_MEC_6078
has molecule: CHEMBL2109334
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6079
type: Mechanism
chembl id: CHEMBL_MEC_6079
has molecule: CHEMBL2109339
has target: CHEMBL4015
mechanism description: C-C chemokine receptor type 2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6080
type: Mechanism
chembl id: CHEMBL_MEC_6080
has molecule: CHEMBL2109343
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_6081
type: Mechanism
chembl id: CHEMBL_MEC_6081
has molecule: CHEMBL2109346
has target: CHEMBL3631
mechanism description: Integrin beta-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6084
type: Mechanism
chembl id: CHEMBL_MEC_6084
has molecule: CHEMBL2109355
has target: CHEMBL3712957
mechanism description: Insulin-like growth factor II inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6083
type: Mechanism
chembl id: CHEMBL_MEC_6083
has molecule: CHEMBL2109355
has target: CHEMBL3217394
mechanism description: Insulin-like growth factor I inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6086
type: Mechanism
chembl id: CHEMBL_MEC_6086
has molecule: CHEMBL2109364
has target: CHEMBL3580494
mechanism description: Mucin-1 other
mechanism action type: OTHER

CHEMBL_MEC_6088
type: Mechanism
chembl id: CHEMBL_MEC_6088
has molecule: CHEMBL2109377
has target: CHEMBL3712901
mechanism description: Connective tissue growth factor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6090
type: Mechanism
chembl id: CHEMBL_MEC_6090
has molecule: CHEMBL2109381
has target: CHEMBL6024
mechanism description: Dickkopf-related protein 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6091
type: Mechanism
chembl id: CHEMBL_MEC_6091
has molecule: CHEMBL2109384
has target: CHEMBL3712916
mechanism description: Delta-like protein 4 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6092
type: Mechanism
chembl id: CHEMBL_MEC_6092
has molecule: CHEMBL2109387
has target: CHEMBL3712972
mechanism description: Epidermal growth factor-like protein 7 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6093
type: Mechanism
chembl id: CHEMBL_MEC_6093
has molecule: CHEMBL2109390
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6097
type: Mechanism
chembl id: CHEMBL_MEC_6097
has molecule: CHEMBL2109397
has target: CHEMBL3712975
mechanism description: Endosialin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5633
type: Mechanism
chembl id: CHEMBL_MEC_5633
has molecule: CHEMBL2104967
has target: CHEMBL1907599
mechanism description: Integrin alpha-4/beta-1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5845
type: Mechanism
chembl id: CHEMBL_MEC_5845
has molecule: CHEMBL2104967
has target: CHEMBL2095184
mechanism description: Integrin alpha-4/beta-7 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4902
type: Mechanism
chembl id: CHEMBL_MEC_4902
has molecule: CHEMBL2104991
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4903
type: Mechanism
chembl id: CHEMBL_MEC_4903
has molecule: CHEMBL2104991
has target: CHEMBL1833
mechanism description: Serotonin 2b (5-HT2b) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4904
type: Mechanism
chembl id: CHEMBL_MEC_4904
has molecule: CHEMBL2104991
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1394
type: Mechanism
chembl id: CHEMBL_MEC_1394
has molecule: CHEMBL2095208
has target: CHEMBL2364675
mechanism description: Cytochrome P450 3A inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2132
type: Mechanism
chembl id: CHEMBL_MEC_2132
has molecule: CHEMBL2095209
mechanism description: Unknown

CHEMBL_MEC_615
type: Mechanism
chembl id: CHEMBL_MEC_615
has molecule: CHEMBL2095211
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_961
type: Mechanism
chembl id: CHEMBL_MEC_961
has molecule: CHEMBL2095212
has target: CHEMBL246
mechanism description: Beta-3 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_6098
type: Mechanism
chembl id: CHEMBL_MEC_6098
has molecule: CHEMBL2109402
has target: CHEMBL5838
mechanism description: Receptor tyrosine-protein kinase erbB-3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5496
type: Mechanism
chembl id: CHEMBL_MEC_5496
has molecule: CHEMBL2109406
has target: CHEMBL5838
mechanism description: Receptor tyrosine-protein kinase erbB-3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6099
type: Mechanism
chembl id: CHEMBL_MEC_6099
has molecule: CHEMBL2109410
has target: CHEMBL3143
mechanism description: Coagulation factor VIII inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_6100
type: Mechanism
chembl id: CHEMBL_MEC_6100
has molecule: CHEMBL2109412
has target: CHEMBL3810
mechanism description: Fibronectin other
mechanism action type: OTHER

CHEMBL_MEC_6101
type: Mechanism
chembl id: CHEMBL_MEC_6101
has molecule: CHEMBL2109417
has target: CHEMBL3390823
mechanism description: Disialoganglioside GD2 other
mechanism action type: OTHER

CHEMBL_MEC_6067
type: Mechanism
chembl id: CHEMBL_MEC_6067
has molecule: CHEMBL2109252
has target: CHEMBL2364168
mechanism description: T cell surface glycoprotein CD3 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1611
type: Mechanism
chembl id: CHEMBL_MEC_1611
has molecule: CHEMBL30219
has target: CHEMBL2093872
has binding site: CHEMBL BS 2618
mechanism description: GABA-A receptor; anion channel positive allosteric modulator
mechanism action type: POSITIVE ALLOSTERIC MODULATOR

CHEMBL_MEC_1348
type: Mechanism
chembl id: CHEMBL_MEC_1348
has molecule: CHEMBL2062258
has target: CHEMBL210
mechanism description: Beta-2 adrenergic receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_21
type: Mechanism
chembl id: CHEMBL_MEC_21
has molecule: CHEMBL1722209
has target: CHEMBL245
mechanism description: Muscarinic acetylcholine receptor M3 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1515
type: Mechanism
chembl id: CHEMBL_MEC_1515
has molecule: CHEMBL1722209
has target: CHEMBL211
mechanism description: Muscarinic acetylcholine receptor M2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_1045
type: Mechanism
chembl id: CHEMBL_MEC_1045
has molecule: CHEMBL2062259
has target: CHEMBL1907589
mechanism description: Neuronal acetylcholine receptor; alpha4/beta2 agonist
mechanism action type: AGONIST

CHEMBL_MEC_1164
type: Mechanism
chembl id: CHEMBL_MEC_1164
has molecule: CHEMBL2062262
has target: CHEMBL2094251
mechanism description: Adrenergic receptor alpha-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_4905
type: Mechanism
chembl id: CHEMBL_MEC_4905
has molecule: CHEMBL2104992
has target: CHEMBL249
mechanism description: Neurokinin 1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2414
type: Mechanism
chembl id: CHEMBL_MEC_2414
has molecule: CHEMBL2107840
has target: CHEMBL3545434
mechanism description: Potassium chelating agent
mechanism action type: CHELATING AGENT

CHEMBL_MEC_2276
type: Mechanism
chembl id: CHEMBL_MEC_2276
has molecule: CHEMBL2107841
has target: CHEMBL1784
mechanism description: Glucagon-like peptide 1 receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5540
type: Mechanism
chembl id: CHEMBL_MEC_5540
has molecule: CHEMBL2107846
has target: CHEMBL3551
mechanism description: TRAIL receptor-1 agonist
mechanism action type: AGONIST

CHEMBL_MEC_5868
type: Mechanism
chembl id: CHEMBL_MEC_5868
has molecule: CHEMBL2107846
has target: CHEMBL1075153
mechanism description: Tumor necrosis factor receptor superfamily member 10B agonist
mechanism action type: AGONIST

CHEMBL_MEC_5541
type: Mechanism
chembl id: CHEMBL_MEC_5541
has molecule: CHEMBL2107856
has target: CHEMBL2916
mechanism description: Telomerase reverse transcriptase inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2272
type: Mechanism
chembl id: CHEMBL_MEC_2272
has molecule: CHEMBL2107857
has target: CHEMBL5913
mechanism description: Leptin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_5542
type: Mechanism
chembl id: CHEMBL_MEC_5542
has molecule: CHEMBL2107859
has target: CHEMBL3712996
mechanism description: Rhesus D antigen inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5470
type: Mechanism
chembl id: CHEMBL_MEC_5470
has molecule: CHEMBL2107861
has target: CHEMBL203
mechanism description: Epidermal growth factor receptor erbB1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5545
type: Mechanism
chembl id: CHEMBL_MEC_5545
has molecule: CHEMBL2107866
has target: CHEMBL1817
mechanism description: Erythropoietin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_2409
type: Mechanism
chembl id: CHEMBL_MEC_2409
has molecule: CHEMBL2107869
has target: CHEMBL1981
mechanism description: Insulin receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_4747
type: Mechanism
chembl id: CHEMBL_MEC_4747
has molecule: CHEMBL2107872
has target: CHEMBL2996
mechanism description: Protein kinase C delta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5471
type: Mechanism
chembl id: CHEMBL_MEC_5471
has molecule: CHEMBL2107874
has target: CHEMBL3580487
mechanism description: Sclerostin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5938
type: Mechanism
chembl id: CHEMBL_MEC_5938
has molecule: CHEMBL2107877
has target: CHEMBL2364158
mechanism description: Tumor necrosis factor ligand superfamily member 13B inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5515
type: Mechanism
chembl id: CHEMBL_MEC_5515
has molecule: CHEMBL2107884
has target: CHEMBL1169600
mechanism description: Interleukin-5 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_81
type: Mechanism
chembl id: CHEMBL_MEC_81
has molecule: CHEMBL2107885
has target: CHEMBL1801
mechanism description: Plasminogen activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_6031
type: Mechanism
chembl id: CHEMBL_MEC_6031
has molecule: CHEMBL2107888
has target: CHEMBL1834
mechanism description: Ig epsilon chain C region inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5962
type: Mechanism
chembl id: CHEMBL_MEC_5962
has molecule: CHEMBL2107890
has target: CHEMBL3390821
mechanism description: B-lymphocyte antigen CD19 binding agent
mechanism action type: BINDING AGENT

CHEMBL_MEC_5472
type: Mechanism
chembl id: CHEMBL_MEC_5472
has molecule: CHEMBL2107917
has target: CHEMBL3580482
mechanism description: Mucin-16 other
mechanism action type: OTHER

CHEMBL_MEC_1075
type: Mechanism
chembl id: CHEMBL_MEC_1075
has molecule: CHEMBL1358
has target: CHEMBL2093866
mechanism description: Estrogen receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2036
type: Mechanism
chembl id: CHEMBL_MEC_2036
has molecule: CHEMBL2108989
has target: CHEMBL2364706
mechanism description: Asparagine hydrolytic enzyme
mechanism action type: HYDROLYTIC ENZYME

CHEMBL_MEC_1795
type: Mechanism
chembl id: CHEMBL_MEC_1795
has molecule: CHEMBL2109047
has target: CHEMBL2364170
mechanism description: Interferon alpha/beta receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_6061
type: Mechanism
chembl id: CHEMBL_MEC_6061
has molecule: CHEMBL2109057
has target: CHEMBL3580507
mechanism description: Ganglioside GD3 other
mechanism action type: OTHER

CHEMBL_MEC_949
type: Mechanism
chembl id: CHEMBL_MEC_949
has molecule: CHEMBL2109065
has target: CHEMBL3618
mechanism description: Coagulation factor V inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_924
type: Mechanism
chembl id: CHEMBL_MEC_924
has molecule: CHEMBL2109065
has target: CHEMBL3143
mechanism description: Coagulation factor VIII inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5562
type: Mechanism
chembl id: CHEMBL_MEC_5562
has molecule: CHEMBL2109084
has target: CHEMBL1801
mechanism description: Plasminogen activator
mechanism action type: ACTIVATOR

CHEMBL_MEC_6062
type: Mechanism
chembl id: CHEMBL_MEC_6062
has molecule: CHEMBL2109095
has target: CHEMBL3631
mechanism description: Integrin beta-2 negative modulator
mechanism action type: NEGATIVE MODULATOR

CHEMBL_MEC_6063
type: Mechanism
chembl id: CHEMBL_MEC_6063
has molecule: CHEMBL2109103
has target: CHEMBL3286077
mechanism description: Eotaxin inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5694
type: Mechanism
chembl id: CHEMBL_MEC_5694
has molecule: CHEMBL2107312
has target: CHEMBL2111463
mechanism description: GABA-B receptor agonist
mechanism action type: AGONIST

CHEMBL_MEC_1298
type: Mechanism
chembl id: CHEMBL_MEC_1298
has molecule: CHEMBL2107333
has target: CHEMBL2069156
mechanism description: Kelch-like ECH-associated protein 1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5357
type: Mechanism
chembl id: CHEMBL_MEC_5357
has molecule: CHEMBL2107339
has target: CHEMBL231
mechanism description: Histamine H1 receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5358
type: Mechanism
chembl id: CHEMBL_MEC_5358
has molecule: CHEMBL2107339
has target: CHEMBL224
mechanism description: Serotonin 2a (5-HT2a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5359
type: Mechanism
chembl id: CHEMBL_MEC_5359
has molecule: CHEMBL2107339
has target: CHEMBL225
mechanism description: Serotonin 2c (5-HT2c) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5360
type: Mechanism
chembl id: CHEMBL_MEC_5360
has molecule: CHEMBL2107339
has target: CHEMBL2095158
mechanism description: Adrenergic receptor alpha-2 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_4553
type: Mechanism
chembl id: CHEMBL_MEC_4553
has molecule: CHEMBL2107341
has target: CHEMBL2093866
mechanism description: Estrogen receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5361
type: Mechanism
chembl id: CHEMBL_MEC_5361
has molecule: CHEMBL2107349
has target: CHEMBL214
mechanism description: Serotonin 1a (5-HT1a) receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5702
type: Mechanism
chembl id: CHEMBL_MEC_5702
has molecule: CHEMBL2107354
has target: CHEMBL1293266
mechanism description: Nucleotide-binding oligomerization domain-containing protein 2 other
mechanism action type: OTHER

CHEMBL_MEC_5537
type: Mechanism
chembl id: CHEMBL_MEC_5537
has molecule: CHEMBL2107359
has target: CHEMBL2366047
mechanism description: Kinetoplast DNA inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_2434
type: Mechanism
chembl id: CHEMBL_MEC_2434
has molecule: CHEMBL2107374
has target: CHEMBL3559391
mechanism description: Vecuronium sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_2433
type: Mechanism
chembl id: CHEMBL_MEC_2433
has molecule: CHEMBL2107374
has target: CHEMBL3559390
mechanism description: Rocuronium sequestering agent
mechanism action type: SEQUESTERING AGENT

CHEMBL_MEC_2407
type: Mechanism
chembl id: CHEMBL_MEC_2407
has molecule: CHEMBL2107381
mechanism description: Unknown

CHEMBL_MEC_5362
type: Mechanism
chembl id: CHEMBL_MEC_5362
has molecule: CHEMBL2107384
has target: CHEMBL274
mechanism description: C-C chemokine receptor type 5 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_2289
type: Mechanism
chembl id: CHEMBL_MEC_2289
has molecule: CHEMBL2107386
has target: CHEMBL3974
mechanism description: Proteinase-activated receptor 1 antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5473
type: Mechanism
chembl id: CHEMBL_MEC_5473
has molecule: CHEMBL2107979
has target: CHEMBL2364163
mechanism description: Complement C5 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5665
type: Mechanism
chembl id: CHEMBL_MEC_5665
has molecule: CHEMBL460785
has target: CHEMBL2608
mechanism description: Lysosomal alpha-glucosidase stabiliser
mechanism action type: STABILISER

CHEMBL_MEC_4580
type: Mechanism
chembl id: CHEMBL_MEC_4580
has molecule: CHEMBL2105694
has target: CHEMBL208
mechanism description: Progesterone receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5834
type: Mechanism
chembl id: CHEMBL_MEC_5834
has molecule: CHEMBL2107358
has target: CHEMBL5988
mechanism description: Bcl-2-like protein 10
mechanism action type: INHIBITOR

CHEMBL_MEC_5833
type: Mechanism
chembl id: CHEMBL_MEC_5833
has molecule: CHEMBL2107358
has target: CHEMBL6044
mechanism description: Bcl-2-related protein A1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5830
type: Mechanism
chembl id: CHEMBL_MEC_5830
has molecule: CHEMBL2107358
has target: CHEMBL4625
mechanism description: Apoptosis regulator Bcl-X inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5832
type: Mechanism
chembl id: CHEMBL_MEC_5832
has molecule: CHEMBL2107358
has target: CHEMBL4361
mechanism description: Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5703
type: Mechanism
chembl id: CHEMBL_MEC_5703
has molecule: CHEMBL2107358
has target: CHEMBL4860
mechanism description: Apoptosis regulator Bcl-2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5831
type: Mechanism
chembl id: CHEMBL_MEC_5831
has molecule: CHEMBL2107358
has target: CHEMBL4677
mechanism description: Apoptosis regulator Bcl-W inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_954
type: Mechanism
chembl id: CHEMBL_MEC_954
has molecule: CHEMBL2103868
has target: CHEMBL3717
mechanism description: Hepatocyte growth factor receptor inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_753
type: Mechanism
chembl id: CHEMBL_MEC_753
has molecule: CHEMBL2103868
has target: CHEMBL279
mechanism description: Vascular endothelial growth factor receptor 2 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_997
type: Mechanism
chembl id: CHEMBL_MEC_997
has molecule: CHEMBL535650
has target: CHEMBL613897
mechanism description: Ferriprotoporphyrin IX inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_1072
type: Mechanism
chembl id: CHEMBL_MEC_1072
has molecule: CHEMBL2105395
has target: CHEMBL2093866
mechanism description: Estrogen receptor modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5447
type: Mechanism
chembl id: CHEMBL_MEC_5447
has molecule: CHEMBL1742995
has target: CHEMBL3580484
mechanism description: Interleukin-12 subunit beta inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5445
type: Mechanism
chembl id: CHEMBL_MEC_5445
has molecule: CHEMBL1742995
has target: CHEMBL2364154
mechanism description: Interleukin-23 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_5446
type: Mechanism
chembl id: CHEMBL_MEC_5446
has molecule: CHEMBL1742995
has target: CHEMBL2364153
mechanism description: Interleukin-12 inhibitor
mechanism action type: INHIBITOR

CHEMBL_MEC_255
type: Mechanism
chembl id: CHEMBL_MEC_255
has molecule: CHEMBL2103735
has target: CHEMBL1855
mechanism description: Gonadotropin-releasing hormone receptor antagonist
mechanism action type: ANTAGONIST

CHEMBL_MEC_5507
type: Mechanism
chembl id: CHEMBL_MEC_5507
has molecule: CHEMBL2103836
has target: CHEMBL2363032
mechanism description: Voltage-gated calcium channel modulator
mechanism action type: MODULATOR

CHEMBL_MEC_5626
type: Mechanism
chembl id: CHEMBL_MEC_5626
has molecule: CHEMBL2103884
has target: CHEMBL2364701
mechanism description: 26S proteosome inhibitor
mechanism action type: INHIBITOR