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notes: k1*E4*E3_star_-k2*E3_star__slash_E4_activ_slash_E4_activ_cplx
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notes: This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. 17(2):227-39. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: 650674
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is described by: http://identifiers.org/pubmed/11312698
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notes: k3*P4_slash_E4_star__deactiv_slash_E4_star__deactiv_cplx
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notes: kp5+ = 6*10^8 M-1 min-1, kp5- = 30 min-1, kpcat,5 = 6 min-1 from Asthagiri and 2001.
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notes: Kc is 6*10^7 M-1 min-1 and Ku is 60 min-1 from Asthagiri, A.R and Lauffenburger, D.A Biotechnol. Prog. 2001, 227-239.
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notes: kp3+ =6*10^8 M-1 min-1, kp3- =30 min-1, kpcat,3 =6 min-1 from Asthagiri and 2001.
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reversible: true
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reversible: false
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notes: Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Asthagiri, A.R and Lauffenburger, D.A Biotechnol. Prog. 2001, 227-239.
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notes: kf*A1A2*C_star_-kb*E0_star_
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notes: k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Asthagiri and 2001.
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species: 651034
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notes: k1*E5_star_*P5-k2*P5_slash_E5_star__deactiv_slash_E5_star__deactiv_cplx
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notes: kp1+ =6*10^8 M-1 min-1, kp1- =30 min-1, kpcat,1 =6 min-1 form Asthagiri and 2001.
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notes: k2+ =6*10^8 M-1 min-1, k2- =30 min-1, kcat,2 =6 min-1 from Asthagire and 2001
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notes: k1+ =6*10^8 M-1 min-1, k1- =30 min-1, kcat,1 =6 min-1 and km caluculated to 0.06 from Asthagiri and 2001.
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notes: k1*E4_star_*P4-k2*P4_slash_E4_star__deactiv_slash_E4_star__deactiv_cplx
type: KineticLaw

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notes: kf*C_star_A1*A2-kb*E0_star_
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reversible: false
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503114
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notes: k1*E2*E1_star_-k2*E1_star__slash_E2_activ_slash_E2_activ_cplx
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651634
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notes: Implementation of adapter feedback induces adaptation of not only the target signal e0* but also signals downstream of the target. k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Asthagiri and Lauffenburger 2001.
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reversible: true
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notes: Kf12 and Kr12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and 2001.
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650401
constant: true
size: 1.0E-18
spatial dimensions: 3.0
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502624
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value: 3.9E-14
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notes: k3+ =6*10^8 M-1 min-1, k3- =30 min-1, kcat,3 =6 min-1 from Asthagiri and 2001.
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502356
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651214
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105615
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502393
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notes: k1*E3*E2_star_-k2*E2_star__slash_E3_activ_slash_E3_activ_cplx
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651234
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product: 501894
reactant: 501882
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notes: Kf1 is 3*10^8 M-1 min-1 and Kr1 is 0.5/sec from Asthagiri and 2001
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105579
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value: 3.8999961E-12
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503126
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notes: k3*P5_slash_E5_star__deactiv_slash_E5_star__deactiv_cplx
type: KineticLaw

105598
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value: 3.9E-14
type: LocalParameter

502381
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species: 650774
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notes: k3*E3_star__slash_E4_activ_slash_E4_activ_cplx
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651274
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fast: false
reversible: true
type: Reaction

502429
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502102
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notes: k1*E1*E0_star_-k2*E0_star__slash_E1_activ_slash_E1_activ_cplx
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651574
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105614
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value: 3.9E-14
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502368
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502514
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type: SpeciesReference

502005
local parameters: 105571
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notes: kf*A2*A1-kb*A1A2
type: KineticLaw

105559
units: 501639
value: 3.9E-13
type: LocalParameter

502720
stoichiometry: 1.0
species: 650894
type: SpeciesReference

105578
units: 501639
value: 3.9E-14
type: LocalParameter

501992
stoichiometry: 1.0
species: 650574
type: SpeciesReference

502442
local parameters: 105590
notes: k3*E2_star__slash_E3_activ_slash_E3_activ_cplx
type: KineticLaw

502029
stoichiometry: 1.0
species: 650474
type: SpeciesReference

651254
kinetic law: 501956
product: 501943
reactant: 501930
reactant: 501918
notes: kf2 and kr2 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 20001.
fast: false
reversible: true
type: Reaction

501810
stoichiometry: 1.0
species: 650494
type: SpeciesReference

650954
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

650474
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

502780
local parameters: 105605
local parameters: 105603
notes: k1*E5*E4_star_-k2*E4_star__slash_E5_activ_slash_E5_activ_cplx
type: KineticLaw

502090
stoichiometry: 1.0
species: 650614
type: SpeciesReference

502865
stoichiometry: 1.0
species: 650994
type: SpeciesReference

502174
stoichiometry: 1.0
species: 650654
type: SpeciesReference

501918
stoichiometry: 1.0
species: 650554
type: SpeciesReference

502247
local parameters: 105582
notes: k3*E1_star__slash_E2_activ_slash_E2_activ_cplx
type: KineticLaw

502696
stoichiometry: 1.0
species: 650914
type: SpeciesReference

105577
units: 501639
value: 1.95E-13
type: LocalParameter

501798
stoichiometry: 2.0
species: 650454
type: SpeciesReference

650434
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.427350427350427
initial amount: NaN
in compartment: 650414
type: Species

105587
units: 501676
value: 3.8999961E-12
type: LocalParameter

501894
stoichiometry: 1.0
species: 650554
type: SpeciesReference

501822
local parameters: 105559
local parameters: 105557
notes: kf*C^2-kb*C2
type: KineticLaw

501980
stoichiometry: 1.0
species: 650514
type: SpeciesReference

502901
stoichiometry: 1.0
species: 651134
type: SpeciesReference

501736
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

651474
kinetic law: 502490
product: 502478
reactant: 502466
reactant: 502454
notes: kp2+ =6*10^8 M-1 min-1, kp2- = 30 min-1, kpcat,2 = 6 min-1 from Asthagiri and 2001.
fast: false
reversible: true
type: Reaction

105586
units: 501639
value: 3.9E-14
type: LocalParameter

651534
kinetic law: 502636
product: 502624
product: 502612
reactant: 502599
fast: false
reversible: false
type: Reaction

502599
stoichiometry: 1.0
species: 650874
type: SpeciesReference

651514
kinetic law: 502587
product: 502575
reactant: 502563
reactant: 502551
notes: k4+ = 6*10^8 M-1 min-1, k4- =30 min-1, kcat,4 =6 min-1 from Asthagiri and 2001.
fast: false
reversible: true
type: Reaction

502162
stoichiometry: 1.0
species: 650734
type: SpeciesReference

503040
stoichiometry: 1.0
species: 651114
type: SpeciesReference

502877
local parameters: 105609
local parameters: 105607
notes: k1*E0_star_*E4_star_-k2*E4_star__slash_E4_star__adpt_fb_slash_E4_star__adpt_fb_cplx
type: KineticLaw

501906
local parameters: 105565
local parameters: 105563
notes: kf*C_star_*A1-kb*C_star_A1
type: KineticLaw

650574
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

502150
local parameters: 105578
notes: k3*E0_star__slash_E1_activ_slash_E1_activ_cplx
type: KineticLaw

650814
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

650774
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

503102
stoichiometry: 1.0
species: 651054
type: SpeciesReference

502078
stoichiometry: 1.0
species: 650594
type: SpeciesReference

501882
stoichiometry: 1.0
species: 650514
type: SpeciesReference

650834
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0427350427350427
initial amount: NaN
in compartment: 650414
type: Species

650674
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

650854
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

502259
stoichiometry: 1.0
species: 650654
type: SpeciesReference

105575
units: 501676
value: 3.8999961E-12
type: LocalParameter

650874
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 650414
type: Species

502684
local parameters: 105601
local parameters: 105599
notes: k1*E3_star_*P3-k2*P3_slash_E3_star__deactiv_slash_E3_star__deactiv_cplx
type: KineticLaw

105589
units: 501639
value: 1.95E-13
type: LocalParameter

502490
local parameters: 105593
local parameters: 105591
notes: k1*E2_star_*P2-k2*P2_slash_E2_star__deactiv_slash_E2_star__deactiv_cplx
type: KineticLaw

501748
stoichiometry: 1.0
species: 651154
type: SpeciesReference

502538
local parameters: 105594
notes: k3*P2_slash_E2_star__deactiv_slash_E2_star__deactiv_cplx
type: KineticLaw

501834
stoichiometry: 1.0
species: 650494
type: SpeciesReference

651374
kinetic law: 502247
product: 502235
product: 502222
reactant: 502210
fast: false
reversible: false
type: Reaction

502344
local parameters: 105586
notes: k3*P1_slash_E1_star__deactiv_slash_E1_star__deactiv_cplx
type: KineticLaw

503001
stoichiometry: 1.0
species: 650934
type: SpeciesReference

502307
stoichiometry: 1.0
species: 650714
type: SpeciesReference

502612
stoichiometry: 1.0
species: 650954
type: SpeciesReference

650634
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0427350427350427
initial amount: NaN
in compartment: 650414
type: Species

105560
units: 501639
value: 3.2487E-13
type: LocalParameter

105610
units: 501639
value: 3.9E-14
type: LocalParameter

105574
units: 501639
value: 1.950039E-13
type: LocalParameter