418422
stoichiometry: 1.0
species: 030652
type: SpeciesReference

030572
constant: true
size: 1.6667E-18
spatial dimensions: 3.0
type: Compartment

958469
units: 418276
value: 4.16666666666667E-17
type: LocalParameter

418410
stoichiometry: 1.0
species: 030592
type: SpeciesReference

958467
units: 418276
value: 1.16666666666667E-19
type: LocalParameter

958465
units: 418240
value: 9.5E-17
type: LocalParameter

030592
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 030572
type: Species

030672
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 030572
type: Species

418288
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

418300
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

030712
kinetic law: 418434
product: 418422
reactant: 418410
reactant: 418397
notes: Binding of NOH-Arginine to Imidazole bound rat brain neuronal Nitric Oxide Synthase. Only Kd is known, Kf and Kb need to be approximated accordingly to match kinetic profiles. Due to lack of appropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 2.7mM = 2700uM Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51.
fast: false
reversible: true
type: Reaction

030632
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6000.0
initial amount: NaN
in compartment: 030572
type: Species

030692
kinetic law: 418385
product: 418373
product: 418361
reactant: 418349
notes: Release of Imidazole from complex of NOH-Arginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51.
fast: false
reversible: true
type: Reaction

MODEL9088294310
units def: 418325
compartment: 030560
species: 030672
species: 030632
notes: This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of NOHArginine to neuronal nitric oxide synthase. Model shows the substrate (NOH-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and NOH-Arginine to form an intermediate that contains bound imidazole and NOH-arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the profile. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 030692
units def: 418276
substance units: 418325
species: 030592
curated: false
compartment: 030572
type: SBMLModel
species: 030652
units def: 418240
area units: area
volume units: 679943
time units: 131570
reaction: 030712
is described by: http://identifiers.org/pubmed/10493814
name: Abu-Soud1999_NOHArginine
species: 030612
length unit: length

418313
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

418434
local parameters: 958471
local parameters: 958469
notes: kf*NOH_minus_Arginine*Im_minus_nNOS-kb*Im_minus_nNOS_minus_NOH_minus_Arginine
type: KineticLaw

030612
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 030572
type: Species

418385
local parameters: 958467
local parameters: 958465
notes: kf*Im_minus_nNOS_minus_NOH_minus_Arginine-kb*nNOS_minus_NOH_minus_Arginine*Imidazole
type: KineticLaw

418264
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

030652
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 030572
type: Species

418337
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

418373
stoichiometry: 1.0
species: 030612
type: SpeciesReference

418361
stoichiometry: 1.0
species: 030672
type: SpeciesReference

958471
units: 418240
value: 1.125E-13
type: LocalParameter

418397
stoichiometry: 1.0
species: 030632
type: SpeciesReference

418252
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

030560
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

418349
stoichiometry: 1.0
species: 030652
type: SpeciesReference