405505
stoichiometry: 1.0
species: 011114
type: SpeciesReference

077455
units: 405385
value: 7.0E-17
type: LocalParameter

405457
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

MODEL9087988095
units def: 405469
length unit: length
species: 011094
species: 011054
type: SBMLModel
species: 011074
reaction: 011154
compartment: 011014
reaction: 011134
units def: 405421
substance units: 405469
is described by: http://identifiers.org/pubmed/10493814
compartment: 010994
area units: area
species: 011114
volume units: 679943
time units: 131570
units def: 405385
name: Abu-Soud1999_HomoArginine
curated: false
species: 011034
notes: This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51 This model shows kinetic binding of HomoArginine to neuronal nitric oxide synthase. Model shows the substrate (Homorginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and Homoarginine to form an intermediate that contains bound imidazole and homoarginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the profile. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

077458
units: 405385
value: 4.16666666666667E-13
type: LocalParameter

405409
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

405553
stoichiometry: 1.0
species: 011034
type: SpeciesReference

405493
stoichiometry: 1.0
species: 011094
type: SpeciesReference

405517
stoichiometry: 1.0
species: 011054
type: SpeciesReference

011134
kinetic law: 405529
product: 405517
product: 405505
reactant: 405493
notes: Release of Imidazole from complex of Homoarginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51
fast: false
reversible: true
type: Reaction

405565
stoichiometry: 1.0
species: 011094
type: SpeciesReference

011074
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6000.0
initial amount: NaN
in compartment: 011014
type: Species

405445
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

405481
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

011034
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 011014
type: Species

011114
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 011014
type: Species

405397
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

405541
stoichiometry: 1.0
species: 011074
type: SpeciesReference

077457
units: 405421
value: 4.16666666666667E-17
type: LocalParameter

011014
constant: true
size: 1.6667E-18
spatial dimensions: 3.0
type: Compartment

010994
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

077456
units: 405421
value: 3.33333333333333E-19
type: LocalParameter

011154
kinetic law: 405577
product: 405565
reactant: 405553
reactant: 405541
notes: Binding of Homoarginine to Imidazole bound rat brain neuronal Nitric Oxide Synthase. Only Kd is known, Kf and Kb need to be approximated accordingly to match kinetic profiles. Due to lack of appropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 10mM = 10000uM Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51
fast: false
reversible: true
type: Reaction

011054
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 011014
type: Species

011094
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 011014
type: Species

405577
local parameters: 077458
local parameters: 077457
notes: kf*Homoarginine*Im_minus_nNOS-kb*Im_minus_nNOS_minus_Homoarginine
type: KineticLaw

405433
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

405529
local parameters: 077456
local parameters: 077455
notes: kf*Im_minus_nNOS_minus_Homoarginine-kb*nNOS_minus_Homoarginine*Imidazole
type: KineticLaw