384080
stoichiometry: 1.0
species: 741619
type: SpeciesReference

374186
stoichiometry: 1.0
species: 737579
type: SpeciesReference

373883
stoichiometry: 1.0
species: 741959
type: SpeciesReference

376940
stoichiometry: 1.0
species: 741299
type: SpeciesReference

690132
units: 371397
value: 6.0E-19
type: LocalParameter

372204
local parameters: 689372
local parameters: 689371
notes: kf*CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB
type: KineticLaw

742438
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 737339
type: Species

689359
units: 371397
value: 4.4998254E-14
type: LocalParameter

748358
kinetic law: 383232
product: 383220
product: 383208
reactant: 383196
fast: false
reversible: false
type: Reaction

689608
units: 371312
value: 7.2E-16
type: LocalParameter

689419
units: 371397
value: 4.1849946E-17
type: LocalParameter

746318
kinetic law: 378284
product: 378272
product: 378260
reactant: 378248
fast: false
reversible: false
type: Reaction

377424
stoichiometry: 1.0
species: 741719
type: SpeciesReference

689680
units: 371312
value: 7.2E-16
type: LocalParameter

690176
units: 371397
value: 2.77776E-19
type: LocalParameter

377146
stoichiometry: 1.0
species: 738199
type: SpeciesReference

372361
stoichiometry: 1.0
species: 737539
type: SpeciesReference

743858
kinetic law: 372445
product: 372433
product: 372421
reactant: 372409
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true
type: Reaction

689458
units: 371397
value: 1.08E-19
type: LocalParameter

378562
stoichiometry: 1.0
species: 738199
type: SpeciesReference

376566
stoichiometry: 1.0
species: 738199
type: SpeciesReference

742478
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

746358
kinetic law: 378381
product: 378369
product: 378357
reactant: 378345
fast: false
reversible: false
type: Reaction

389070
stoichiometry: 1.0
species: 741639
type: SpeciesReference

372506
stoichiometry: 1.0
species: 739239
type: SpeciesReference

690208
units: 371312
value: 5.0E-18
type: LocalParameter

387447
stoichiometry: 1.0
species: 742038
type: SpeciesReference

381817
local parameters: 689874
local parameters: 689872
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

689754
units: 371312
value: 8.1E-16
type: LocalParameter

381612
stoichiometry: 1.0
species: 739759
type: SpeciesReference

382807
stoichiometry: 1.0
species: 740099
type: SpeciesReference

749658
kinetic law: 386385
product: 386373
reactant: 386361
reactant: 386349
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true
type: Reaction

748398
kinetic law: 383329
product: 383317
product: 383305
reactant: 383293
fast: false
reversible: false
type: Reaction

689713
units: 371312
value: 1.8E-16
type: LocalParameter

375990
stoichiometry: 1.0
species: 738359
type: SpeciesReference

689459
units: 371312
value: 8.0E-20
type: LocalParameter

388850
stoichiometry: 1.0
species: 742978
type: SpeciesReference

386517
stoichiometry: 1.0
species: 741039
type: SpeciesReference

386096
stoichiometry: 1.0
species: 741019
type: SpeciesReference

378296
stoichiometry: 1.0
species: 741759
type: SpeciesReference

388740
stoichiometry: 1.0
species: 741659
type: SpeciesReference

742038
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

750318
kinetic law: 387990
product: 387978
product: 387966
reactant: 387953
fast: false
reversible: false
type: Reaction

381927
stoichiometry: 1.0
species: 739819
type: SpeciesReference

379301
local parameters: 689757
local parameters: 689755
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

689751
units: 371397
value: 5.399946E-16
type: LocalParameter

379265
stoichiometry: 1.0
species: 737979
type: SpeciesReference

689417
units: 371312
value: 1.0E-18
type: LocalParameter

744538
kinetic law: 373968
product: 373956
reactant: 373944
reactant: 373932
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers Note that this reaction also incorporates a translocation between compartments of different volumes.
fast: false
reversible: true
type: Reaction

690178
units: 371312
value: 2.0E-17
type: LocalParameter

744938
kinetic law: 374938
product: 374926
reactant: 374914
reactant: 374902
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

690205
units: 371397
value: 2.77776E-19
type: LocalParameter

746998
kinetic law: 379933
product: 379921
product: 379908
reactant: 379896
fast: false
reversible: false
type: Reaction

738819
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

382711
stoichiometry: 1.0
species: 740059
type: SpeciesReference

377740
stoichiometry: 1.0
species: 738739
type: SpeciesReference

379739
local parameters: 689776
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

743658
kinetic law: 371963
product: 371951
reactant: 371939
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

748318
kinetic law: 383135
product: 383122
product: 383110
reactant: 383098
fast: false
reversible: false
type: Reaction

739579
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

386662
stoichiometry: 1.0
species: 741859
type: SpeciesReference

384755
stoichiometry: 1.0
species: 741659
type: SpeciesReference

388111
stoichiometry: 1.0
species: 742978
type: SpeciesReference

690134
units: 371312
value: 2.4E-16
type: LocalParameter

383958
local parameters: 689974
local parameters: 689973
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

689712
units: 371312
value: 7.2E-16
type: LocalParameter

689456
units: 371312
value: 8.0E-20
type: LocalParameter

741399
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

742039
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

381781
stoichiometry: 1.0
species: 741759
type: SpeciesReference

372868
stoichiometry: 1.0
species: 740339
type: SpeciesReference

389185
stoichiometry: 1.0
species: 742978
type: SpeciesReference

739539
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689416
units: 371397
value: 4.9998E-15
type: LocalParameter

689569
units: 371397
value: 3.420036E-18
type: LocalParameter

689752
units: 371312
value: 3.24E-15
type: LocalParameter

377218
local parameters: 689659
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

690179
units: 371312
value: 5.0E-18
type: LocalParameter

376344
local parameters: 689619
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

690206
units: 371312
value: 2.0E-17
type: LocalParameter

372277
stoichiometry: 1.0
species: 737539
type: SpeciesReference

742078
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 737359
type: Species

382122
stoichiometry: 1.0
species: 739859
type: SpeciesReference

373908
stoichiometry: 1.0
species: 742398
type: SpeciesReference

744298
kinetic law: 373447
product: 373435
reactant: 373423
reactant: 373411
fast: false
reversible: true
type: Reaction

689607
units: 371397
value: 1.8106416E-16
type: LocalParameter

749278
kinetic law: 385455
product: 385443
product: 385431
reactant: 385419
fast: false
reversible: false
type: Reaction

376232
stoichiometry: 1.0
species: 738199
type: SpeciesReference

387760
stoichiometry: 1.0
species: 742078
type: SpeciesReference

387508
local parameters: 690135
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

690135
units: 371312
value: 6.0E-17
type: LocalParameter

384417
stoichiometry: 1.0
species: 740379
type: SpeciesReference

690203
units: 371312
value: 5.0E-18
type: LocalParameter

376916
stoichiometry: 1.0
species: 738199
type: SpeciesReference

389209
local parameters: 690206
local parameters: 690205
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

745958
kinetic law: 377412
product: 377400
product: 377388
reactant: 377376
fast: false
reversible: false
type: Reaction

737719
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 737339
type: Species

386132
local parameters: 690075
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

375267
stoichiometry: 1.0
species: 738059
type: SpeciesReference

690136
units: 371397
value: 4.99998E-20
type: LocalParameter

386493
stoichiometry: 1.0
species: 741119
type: SpeciesReference

689710
units: 371397
value: 2.011824E-17
type: LocalParameter

689863
units: 371397
value: 3.999888E-17
type: LocalParameter

690172
units: 371397
value: 2.77776E-19
type: LocalParameter

380694
stoichiometry: 1.0
species: 739239
type: SpeciesReference

380174
local parameters: 689797
local parameters: 689796
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

382867
stoichiometry: 1.0
species: 740119
type: SpeciesReference

385455
local parameters: 690043
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

689567
units: 371312
value: 3.06E-17
type: LocalParameter

382795
local parameters: 689920
local parameters: 689919
notes: k1*cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

385987
local parameters: 690069
local parameters: 690067
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

382598
local parameters: 689910
local parameters: 689908
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

380077
local parameters: 689793
local parameters: 689791
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

384839
stoichiometry: 1.0
species: 740759
type: SpeciesReference

747118
kinetic law: 380222
product: 380210
product: 380198
reactant: 380186
fast: false
reversible: false
type: Reaction

389148
stoichiometry: 1.0
species: 742978
type: SpeciesReference

382170
stoichiometry: 1.0
species: 741779
type: SpeciesReference

744338
kinetic law: 373532
product: 373519
reactant: 373507
fast: false
reversible: true
type: Reaction

689685
units: 371312
value: 7.2E-16
type: LocalParameter

689862
units: 371312
value: 5.4E-16
type: LocalParameter

690060
units: 371312
value: 1.4E-17
type: LocalParameter

378454
stoichiometry: 1.0
species: 741579
type: SpeciesReference

745918
kinetic law: 377316
product: 377303
product: 377291
reactant: 377278
fast: false
reversible: false
type: Reaction

375520
local parameters: 689566
local parameters: 689564
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

388195
stoichiometry: 1.0
species: 741679
type: SpeciesReference

378999
stoichiometry: 1.0
species: 739019
type: SpeciesReference

689566
units: 371312
value: 1.224E-16
type: LocalParameter

387700
local parameters: 690143
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

373338
stoichiometry: 1.0
species: 741839
type: SpeciesReference

377969
stoichiometry: 1.0
species: 741559
type: SpeciesReference

387363
local parameters: 690130
local parameters: 690128
notes: k1*CaMKII_PSD_slash_CaMKII_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

375460
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690138
units: 371312
value: 2.0E-17
type: LocalParameter

741319
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373483
stoichiometry: 1.0
species: 741719
type: SpeciesReference

740999
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374794
local parameters: 689531
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

375713
local parameters: 689575
local parameters: 689573
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

744698
kinetic law: 374355
product: 374343
reactant: 374331
reactant: 374319
fast: false
reversible: true
type: Reaction

690174
units: 371312
value: 2.0E-17
type: LocalParameter

380512
local parameters: 689812
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

388256
stoichiometry: 1.0
species: 741759
type: SpeciesReference

386228
local parameters: 690079
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

745158
kinetic law: 375472
product: 375460
product: 375448
reactant: 375436
fast: false
reversible: false
type: Reaction

380875
stoichiometry: 1.0
species: 741339
type: SpeciesReference

690061
units: 371312
value: 3.5E-18
type: LocalParameter

749858
kinetic law: 386880
product: 386868
reactant: 386855
reactant: 386843
fast: false
reversible: true
type: Reaction

689682
units: 371312
value: 1.8E-16
type: LocalParameter

749778
kinetic law: 386687
product: 386675
reactant: 386662
reactant: 386650
fast: false
reversible: true
type: Reaction

388679
stoichiometry: 1.0
species: 741699
type: SpeciesReference

690202
units: 371312
value: 2.0E-17
type: LocalParameter

385395
stoichiometry: 1.0
species: 740879
type: SpeciesReference

749818
kinetic law: 386783
product: 386771
reactant: 386759
reactant: 386747
fast: false
reversible: true
type: Reaction

387484
stoichiometry: 1.0
species: 741958
type: SpeciesReference

750538
kinetic law: 388521
product: 388509
reactant: 388497
reactant: 388485
fast: false
reversible: true
type: Reaction

387978
stoichiometry: 1.0
species: 742978
type: SpeciesReference

741419
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

383886
stoichiometry: 1.0
species: 741719
type: SpeciesReference

374637
stoichiometry: 1.0
species: 737699
type: SpeciesReference

382230
stoichiometry: 1.0
species: 741839
type: SpeciesReference

690139
units: 371312
value: 5.0E-18
type: LocalParameter

375688
stoichiometry: 1.0
species: 738199
type: SpeciesReference

373012
local parameters: 689426
local parameters: 689425
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*Anchor
type: KineticLaw

383401
stoichiometry: 1.0
species: 741539
type: SpeciesReference

748178
kinetic law: 382795
product: 382783
reactant: 382771
reactant: 382759
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true
type: Reaction

378938
stoichiometry: 1.0
species: 737899
type: SpeciesReference

384791
stoichiometry: 1.0
species: 741779
type: SpeciesReference

690175
units: 371312
value: 5.0E-18
type: LocalParameter

383098
stoichiometry: 1.0
species: 740399
type: SpeciesReference

689860
units: 371312
value: 2.16E-15
type: LocalParameter

741359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689683
units: 371397
value: 2.011824E-17
type: LocalParameter

689944
units: 371312
value: 1.7E-18
type: LocalParameter

748618
kinetic law: 383862
product: 383850
reactant: 383838
reactant: 383826
fast: false
reversible: true
type: Reaction

690063
units: 371397
value: 8.7498E-18
type: LocalParameter

738339
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

749438
kinetic law: 385842
product: 385830
product: 385818
reactant: 385806
fast: false
reversible: false
type: Reaction

381407
stoichiometry: 1.0
species: 739239
type: SpeciesReference

371699
local parameters: 689339
local parameters: 689338
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM
type: KineticLaw

387652
local parameters: 690142
local parameters: 690140
notes: k1*CaMKII_PSD_slash_CaMKII_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

381105
stoichiometry: 1.0
species: 741619
type: SpeciesReference

690027
units: 371397
value: 8.7498E-18
type: LocalParameter

381178
stoichiometry: 1.0
species: 739239
type: SpeciesReference

388583
stoichiometry: 1.0
species: 741759
type: SpeciesReference

387592
stoichiometry: 1.0
species: 742938
type: SpeciesReference

375412
stoichiometry: 1.0
species: 738239
type: SpeciesReference

744038
kinetic law: 372880
product: 372868
reactant: 372856
reactant: 372844
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

380827
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689411
units: 371312
value: 5.4E-15
type: LocalParameter

384152
local parameters: 689983
local parameters: 689982
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

689943
units: 371312
value: 6.8E-18
type: LocalParameter

746538
kinetic law: 378817
product: 378805
reactant: 378793
reactant: 378781
fast: false
reversible: true
type: Reaction

380282
stoichiometry: 1.0
species: 739479
type: SpeciesReference

690064
units: 371312
value: 1.4E-17
type: LocalParameter

689866
units: 371312
value: 5.4E-16
type: LocalParameter

376627
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690028
units: 371312
value: 1.4E-17
type: LocalParameter

373811
stoichiometry: 1.0
species: 741998
type: SpeciesReference

742778
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

384561
stoichiometry: 1.0
species: 741579
type: SpeciesReference

378140
local parameters: 689703
local parameters: 689701
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

748658
kinetic law: 383958
product: 383946
reactant: 383934
reactant: 383922
fast: false
reversible: true
type: Reaction

384224
stoichiometry: 1.0
species: 740379
type: SpeciesReference

383668
local parameters: 689961
local parameters: 689959
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

385768
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689410
units: 371312
value: 5.4E-15
type: LocalParameter

748578
kinetic law: 383765
product: 383753
reactant: 383741
reactant: 383729
fast: false
reversible: true
type: Reaction

749478
kinetic law: 385939
product: 385927
product: 385915
reactant: 385903
fast: false
reversible: false
type: Reaction

376988
stoichiometry: 1.0
species: 738559
type: SpeciesReference

738379
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689824
units: 371312
value: 2.16E-15
type: LocalParameter

745898
kinetic law: 377266
product: 377254
reactant: 377242
reactant: 377230
fast: false
reversible: true
type: Reaction

690200
units: 371397
value: 2.77776E-19
type: LocalParameter

689827
units: 371397
value: 3.5998992E-16
type: LocalParameter

386337
local parameters: 690084
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

386735
local parameters: 690102
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

746738
kinetic law: 379301
product: 379289
reactant: 379277
reactant: 379265
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

744078
kinetic law: 372964
product: 372952
reactant: 372940
fast: false
reversible: true
type: Reaction

739159
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690170
units: 371312
value: 2.0E-17
type: LocalParameter

372820
stoichiometry: 1.0
species: 740379
type: SpeciesReference

737659
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371602
local parameters: 689333
local parameters: 689332
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2
type: KineticLaw

371795
stoichiometry: 1.0
species: 740219
type: SpeciesReference

380403
stoichiometry: 1.0
species: 739239
type: SpeciesReference

386807
stoichiometry: 1.0
species: 741959
type: SpeciesReference

750258
kinetic law: 387845
product: 387833
reactant: 387820
reactant: 387808
fast: false
reversible: true
type: Reaction

748978
kinetic law: 384731
product: 384719
reactant: 384707
reactant: 384695
fast: false
reversible: true
type: Reaction

689865
units: 371312
value: 2.16E-15
type: LocalParameter

375315
stoichiometry: 1.0
species: 738219
type: SpeciesReference

384309
stoichiometry: 1.0
species: 741819
type: SpeciesReference

372421
stoichiometry: 1.0
species: 739239
type: SpeciesReference

373229
local parameters: 689441
local parameters: 689440
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

387254
stoichiometry: 1.0
species: 742018
type: SpeciesReference

373666
stoichiometry: 1.0
species: 742059
type: SpeciesReference

379872
stoichiometry: 1.0
species: 739399
type: SpeciesReference

382520
stoichiometry: 1.0
species: 741659
type: SpeciesReference

384249
local parameters: 689988
local parameters: 689986
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

689826
units: 371312
value: 5.4E-16
type: LocalParameter

690066
units: 371312
value: 3.5E-18
type: LocalParameter

382759
stoichiometry: 1.0
species: 737539
type: SpeciesReference

380584
stoichiometry: 1.0
species: 741359
type: SpeciesReference

689941
units: 371397
value: 8.7498E-18
type: LocalParameter

379494
local parameters: 689766
local parameters: 689764
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

690171
units: 371312
value: 5.0E-18
type: LocalParameter

375821
stoichiometry: 1.0
species: 738319
type: SpeciesReference

375797
stoichiometry: 1.0
species: 738319
type: SpeciesReference

379349
local parameters: 689758
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

388509
stoichiometry: 1.0
species: 742238
type: SpeciesReference

373121
stoichiometry: 1.0
species: 741539
type: SpeciesReference

383256
stoichiometry: 1.0
species: 740379
type: SpeciesReference

378829
stoichiometry: 1.0
species: 738959
type: SpeciesReference

742258
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359
type: Species

373968
local parameters: 689492
local parameters: 689491
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_PSD_slash_NMDAR-kb*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

378781
stoichiometry: 1.0
species: 741779
type: SpeciesReference

383910
local parameters: 689971
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

387869
stoichiometry: 1.0
species: 741739
type: SpeciesReference

749018
kinetic law: 384827
product: 384815
reactant: 384803
reactant: 384791
fast: false
reversible: true
type: Reaction

374686
stoichiometry: 1.0
species: 742598
type: SpeciesReference

383777
stoichiometry: 1.0
species: 740539
type: SpeciesReference

379409
stoichiometry: 1.0
species: 739299
type: SpeciesReference

386024
stoichiometry: 1.0
species: 740379
type: SpeciesReference

374379
stoichiometry: 1.0
species: 737759
type: SpeciesReference

750298
kinetic law: 387941
product: 387929
reactant: 387917
reactant: 387905
fast: false
reversible: true
type: Reaction

742738
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

388788
stoichiometry: 1.0
species: 742978
type: SpeciesReference

740099
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

387929
stoichiometry: 1.0
species: 742118
type: SpeciesReference

741019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

745098
kinetic law: 375328
product: 375315
reactant: 375303
reactant: 375291
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

371939
stoichiometry: 1.0
species: 737919
type: SpeciesReference

382915
stoichiometry: 1.0
species: 740019
type: SpeciesReference

741679
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689829
units: 371312
value: 2.16E-15
type: LocalParameter

377533
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689940
units: 371312
value: 1.7E-18
type: LocalParameter

690067
units: 371397
value: 8.7498E-18
type: LocalParameter

375194
stoichiometry: 1.0
species: 740339
type: SpeciesReference

689757
units: 371312
value: 3.24E-15
type: LocalParameter

381286
local parameters: 689848
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

383994
stoichiometry: 1.0
species: 740379
type: SpeciesReference

381371
stoichiometry: 1.0
species: 739239
type: SpeciesReference

386843
stoichiometry: 1.0
species: 741958
type: SpeciesReference

372760
stoichiometry: 1.0
species: 740259
type: SpeciesReference

373629
stoichiometry: 1.0
species: 741199
type: SpeciesReference

380936
stoichiometry: 1.0
species: 739619
type: SpeciesReference

384863
stoichiometry: 1.0
species: 740379
type: SpeciesReference

376832
local parameters: 689641
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

690024
units: 371312
value: 1.4E-17
type: LocalParameter

377170
local parameters: 689658
local parameters: 689656
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

371711
stoichiometry: 1.0
species: 737819
type: SpeciesReference

382339
stoichiometry: 1.0
species: 739239
type: SpeciesReference

380029
local parameters: 689790
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

377630
stoichiometry: 1.0
species: 738199
type: SpeciesReference

381214
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689758
units: 371312
value: 8.1E-16
type: LocalParameter

739899
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

744378
kinetic law: 373605
product: 373593
reactant: 373581
fast: false
reversible: true
type: Reaction

387556
local parameters: 690138
local parameters: 690136
notes: k1*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

689414
units: 371397
value: 0.0
type: LocalParameter

381721
local parameters: 689869
local parameters: 689868
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

740579
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374526
stoichiometry: 1.0
species: 742598
type: SpeciesReference

374478
stoichiometry: 1.0
species: 737579
type: SpeciesReference

748018
kinetic law: 382399
product: 382387
reactant: 382375
reactant: 382363
fast: false
reversible: true
type: Reaction

747518
kinetic law: 381190
product: 381178
product: 381166
reactant: 381154
fast: false
reversible: false
type: Reaction

387170
local parameters: 690122
local parameters: 690120
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

745638
kinetic law: 376639
product: 376627
product: 376615
reactant: 376603
fast: false
reversible: false
type: Reaction

690025
units: 371312
value: 3.5E-18
type: LocalParameter

384044
stoichiometry: 1.0
species: 740599
type: SpeciesReference

379518
stoichiometry: 1.0
species: 741239
type: SpeciesReference

373556
stoichiometry: 1.0
species: 737559
type: SpeciesReference

382278
stoichiometry: 1.0
species: 739239
type: SpeciesReference

375640
stoichiometry: 1.0
species: 740299
type: SpeciesReference

745538
kinetic law: 376396
product: 376384
reactant: 376371
reactant: 376358
fast: false
reversible: true
type: Reaction

379156
local parameters: 689749
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

378079
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689413
units: 371312
value: 1.0E-17
type: LocalParameter

383147
stoichiometry: 1.0
species: 741719
type: SpeciesReference

689755
units: 371397
value: 5.399946E-16
type: LocalParameter

372060
local parameters: 689363
local parameters: 689362
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1
type: KineticLaw

690069
units: 371312
value: 1.4E-17
type: LocalParameter

738559
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689869
units: 371312
value: 2.16E-15
type: LocalParameter

741639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

388631
stoichiometry: 1.0
species: 742258
type: SpeciesReference

371373
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

739819
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

744718
kinetic law: 374404
product: 374391
product: 374379
reactant: 374367
fast: false
reversible: false
type: Reaction

388437
stoichiometry: 1.0
species: 742218
type: SpeciesReference

381890
stoichiometry: 1.0
species: 739239
type: SpeciesReference

376015
stoichiometry: 1.0
species: 738359
type: SpeciesReference

384985
stoichiometry: 1.0
species: 741759
type: SpeciesReference

386300
stoichiometry: 1.0
species: 737779
type: SpeciesReference

689868
units: 371397
value: 3.999888E-17
type: LocalParameter

741998
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

372711
local parameters: 689405
local parameters: 689404
notes: kf*AC_slash_PDE1*CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1
type: KineticLaw

744758
kinetic law: 374502
product: 374490
product: 374478
reactant: 374466
fast: false
reversible: false
type: Reaction

379457
stoichiometry: 1.0
species: 741199
type: SpeciesReference

747878
kinetic law: 382062
product: 382050
product: 382038
reactant: 382026
fast: false
reversible: false
type: Reaction

747558
kinetic law: 381286
product: 381274
product: 381262
reactant: 381250
fast: false
reversible: false
type: Reaction

386409
stoichiometry: 1.0
species: 739979
type: SpeciesReference

379664
stoichiometry: 1.0
species: 739239
type: SpeciesReference

378526
local parameters: 689721
local parameters: 689719
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

375206
stoichiometry: 1.0
species: 738059
type: SpeciesReference

388960
local parameters: 690195
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

740619
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

388364
stoichiometry: 1.0
species: 742978
type: SpeciesReference

374076
stoichiometry: 1.0
species: 737439
type: SpeciesReference

384948
stoichiometry: 1.0
species: 741599
type: SpeciesReference

737919
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

738439
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371987
stoichiometry: 1.0
species: 737419
type: SpeciesReference

382014
local parameters: 689883
local parameters: 689881
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

689989
units: 371312
value: 1.7E-18
type: LocalParameter

374331
stoichiometry: 1.0
species: 737419
type: SpeciesReference

743598
kinetic law: 371831
product: 371819
reactant: 371807
reactant: 371795
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

740839
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

382819
stoichiometry: 1.0
species: 740019
type: SpeciesReference

385830
stoichiometry: 1.0
species: 740379
type: SpeciesReference

382303
local parameters: 689896
local parameters: 689895
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

748718
kinetic law: 384104
product: 384092
product: 384080
reactant: 384068
fast: false
reversible: false
type: Reaction

388800
stoichiometry: 1.0
species: 742298
type: SpeciesReference

743818
kinetic law: 372349
product: 372337
reactant: 372325
reactant: 372313
fast: false
reversible: true
type: Reaction

373169
stoichiometry: 1.0
species: 741359
type: SpeciesReference

749178
kinetic law: 385215
product: 385203
reactant: 385191
reactant: 385179
fast: false
reversible: true
type: Reaction

374429
stoichiometry: 1.0
species: 737419
type: SpeciesReference

380622
stoichiometry: 1.0
species: 741239
type: SpeciesReference

746838
kinetic law: 379542
product: 379530
product: 379518
reactant: 379506
fast: false
reversible: false
type: Reaction

381624
local parameters: 689865
local parameters: 689863
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

750818
kinetic law: 389209
product: 389197
reactant: 389185
reactant: 389173
fast: false
reversible: true
type: Reaction

382975
stoichiometry: 1.0
species: 740179
type: SpeciesReference

740259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

376409
stoichiometry: 1.0
species: 738439
type: SpeciesReference

749618
kinetic law: 386276
product: 386264
reactant: 386252
reactant: 386240
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

690031
units: 371397
value: 8.7498E-18
type: LocalParameter

381250
stoichiometry: 1.0
species: 739679
type: SpeciesReference

738779
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

379908
stoichiometry: 1.0
species: 741279
type: SpeciesReference

689649
units: 371312
value: 7.2E-16
type: LocalParameter

380984
stoichiometry: 1.0
species: 739239
type: SpeciesReference

373738
stoichiometry: 1.0
species: 741959
type: SpeciesReference

377061
stoichiometry: 1.0
species: 738579
type: SpeciesReference

382375
stoichiometry: 1.0
species: 739239
type: SpeciesReference

740879
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

380367
local parameters: 689806
local parameters: 689805
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

741999
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

740219
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

372469
stoichiometry: 1.0
species: 739239
type: SpeciesReference

742838
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377812
stoichiometry: 1.0
species: 741799
type: SpeciesReference

385648
local parameters: 690052
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

385287
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748758
kinetic law: 384200
product: 384188
product: 384176
reactant: 384164
fast: false
reversible: false
type: Reaction

749378
kinetic law: 385696
product: 385684
reactant: 385672
reactant: 385660
fast: false
reversible: true
type: Reaction

379627
stoichiometry: 1.0
species: 739239
type: SpeciesReference

747718
kinetic law: 381672
product: 381660
product: 381648
reactant: 381636
fast: false
reversible: false
type: Reaction

374746
local parameters: 689530
local parameters: 689528
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

387134
stoichiometry: 1.0
species: 741978
type: SpeciesReference

689949
units: 371312
value: 1.7E-18
type: LocalParameter

738059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 737339
type: Species

749698
kinetic law: 386481
product: 386469
reactant: 386457
reactant: 386445
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

378030
stoichiometry: 1.0
species: 738799
type: SpeciesReference

389021
stoichiometry: 1.0
species: 742338
type: SpeciesReference

374040
stoichiometry: 1.0
species: 737419
type: SpeciesReference

750358
kinetic law: 388087
product: 388075
product: 388063
reactant: 388051
fast: false
reversible: false
type: Reaction

746158
kinetic law: 377896
product: 377884
product: 377872
reactant: 377860
fast: false
reversible: false
type: Reaction

690034
units: 371312
value: 3.5E-18
type: LocalParameter

383377
local parameters: 689947
local parameters: 689946
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

378188
local parameters: 689704
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

381866
local parameters: 689875
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

379228
stoichiometry: 1.0
species: 740079
type: SpeciesReference

379554
stoichiometry: 1.0
species: 741219
type: SpeciesReference

378636
stoichiometry: 1.0
species: 738919
type: SpeciesReference

689646
units: 371312
value: 1.8E-16
type: LocalParameter

385720
stoichiometry: 1.0
species: 741579
type: SpeciesReference

372964
local parameters: 689423
local parameters: 689422
notes: kf*AMPAR_slash_GluR23_M-kb*AMPAR_slash_GluR23_I
type: KineticLaw

690033
units: 371312
value: 1.4E-17
type: LocalParameter

742878
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

381334
local parameters: 689851
local parameters: 689850
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

388912
local parameters: 690194
local parameters: 690192
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

388328
local parameters: 690170
local parameters: 690168
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

744258
kinetic law: 373350
product: 373338
reactant: 373326
reactant: 373314
fast: false
reversible: true
type: Reaction

386892
stoichiometry: 1.0
species: 741918
type: SpeciesReference

746198
kinetic law: 377993
product: 377981
product: 377969
reactant: 377957
fast: false
reversible: false
type: Reaction

388400
stoichiometry: 1.0
species: 742978
type: SpeciesReference

372650
stoichiometry: 1.0
species: 740039
type: SpeciesReference

386457
stoichiometry: 1.0
species: 741039
type: SpeciesReference

738739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

388473
local parameters: 690175
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

386953
stoichiometry: 1.0
species: 741859
type: SpeciesReference

386505
stoichiometry: 1.0
species: 737919
type: SpeciesReference

372602
stoichiometry: 1.0
species: 739979
type: SpeciesReference

738099
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 737339
type: Species

689647
units: 371397
value: 1.8106416E-16
type: LocalParameter

379566
stoichiometry: 1.0
species: 739239
type: SpeciesReference

376384
stoichiometry: 1.0
species: 738439
type: SpeciesReference

372011
local parameters: 689360
local parameters: 689359
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

689820
units: 371312
value: 2.16E-15
type: LocalParameter

689947
units: 371312
value: 6.8E-18
type: LocalParameter

750138
kinetic law: 387556
product: 387544
reactant: 387532
reactant: 387520
fast: false
reversible: true
type: Reaction

689985
units: 371312
value: 3.5E-18
type: LocalParameter

739079
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

382484
stoichiometry: 1.0
species: 739939
type: SpeciesReference

689360
units: 371312
value: 9.0E-18
type: LocalParameter

747498
kinetic law: 381141
product: 381129
reactant: 381117
reactant: 381105
fast: false
reversible: true
type: Reaction

385539
stoichiometry: 1.0
species: 740379
type: SpeciesReference

373847
stoichiometry: 1.0
species: 737759
type: SpeciesReference

383632
stoichiometry: 1.0
species: 741739
type: SpeciesReference

745458
kinetic law: 376195
product: 376183
reactant: 376171
reactant: 376159
fast: false
reversible: true
type: Reaction

385684
stoichiometry: 1.0
species: 740939
type: SpeciesReference

689908
units: 371312
value: 4.05E-16
type: LocalParameter

383049
stoichiometry: 1.0
species: 741719
type: SpeciesReference

744858
kinetic law: 374746
product: 374734
reactant: 374722
reactant: 374710
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

384453
stoichiometry: 1.0
species: 740679
type: SpeciesReference

750578
kinetic law: 388619
product: 388607
reactant: 388595
reactant: 388583
fast: false
reversible: true
type: Reaction

387604
local parameters: 690139
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

737359
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

380779
stoichiometry: 1.0
species: 741319
type: SpeciesReference

381660
stoichiometry: 1.0
species: 739239
type: SpeciesReference

740959
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689821
units: 371312
value: 5.4E-16
type: LocalParameter

381068
stoichiometry: 1.0
species: 741719
type: SpeciesReference

376518
stoichiometry: 1.0
species: 741459
type: SpeciesReference

750178
kinetic law: 387652
product: 387640
reactant: 387628
reactant: 387616
fast: false
reversible: true
type: Reaction

388002
stoichiometry: 1.0
species: 741539
type: SpeciesReference

745498
kinetic law: 376292
product: 376280
reactant: 376268
reactant: 376256
fast: false
reversible: true
type: Reaction

689986
units: 371397
value: 8.7498E-18
type: LocalParameter

372542
local parameters: 689393
local parameters: 689392
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA
type: KineticLaw

378104
stoichiometry: 1.0
species: 741819
type: SpeciesReference

383037
local parameters: 689931
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

379775
stoichiometry: 1.0
species: 739379
type: SpeciesReference

380246
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689907
units: 371312
value: 5.4E-16
type: LocalParameter

744898
kinetic law: 374842
product: 374830
reactant: 374818
reactant: 374806
fast: false
reversible: true
type: Reaction

739379
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

375364
stoichiometry: 1.0
species: 738199
type: SpeciesReference

378200
stoichiometry: 1.0
species: 741819
type: SpeciesReference

386916
stoichiometry: 1.0
species: 741859
type: SpeciesReference

387062
stoichiometry: 1.0
species: 741938
type: SpeciesReference

371759
stoichiometry: 2.0
species: 740279
type: SpeciesReference

748238
kinetic law: 382939
product: 382927
product: 382915
reactant: 382903
fast: false
reversible: false
type: Reaction

749738
kinetic law: 386578
product: 386565
reactant: 386553
reactant: 386541
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

740799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

690030
units: 371312
value: 3.5E-18
type: LocalParameter

689362
units: 371312
value: 9.0E-17
type: LocalParameter

745118
kinetic law: 375376
product: 375364
product: 375352
reactant: 375340
fast: false
reversible: false
type: Reaction

378708
stoichiometry: 1.0
species: 738939
type: SpeciesReference

382411
stoichiometry: 1.0
species: 739919
type: SpeciesReference

747158
kinetic law: 380318
product: 380306
product: 380294
reactant: 380282
fast: false
reversible: false
type: Reaction

384345
local parameters: 689992
local parameters: 689991
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

386385
local parameters: 690087
local parameters: 690085
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

378744
stoichiometry: 1.0
species: 741599
type: SpeciesReference

387966
stoichiometry: 1.0
species: 741639
type: SpeciesReference

373775
local parameters: 689480
local parameters: 689479
notes: kf*CaMKII_PSD_slash_CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

387339
stoichiometry: 1.0
species: 742918
type: SpeciesReference

375749
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689823
units: 371397
value: 3.5998992E-16
type: LocalParameter

689946
units: 371397
value: 8.7498E-18
type: LocalParameter

374782
stoichiometry: 1.0
species: 742618
type: SpeciesReference

689988
units: 371312
value: 6.8E-18
type: LocalParameter

374004
stoichiometry: 1.0
species: 741998
type: SpeciesReference

377860
stoichiometry: 1.0
species: 738759
type: SpeciesReference

748278
kinetic law: 383037
product: 383025
product: 383013
reactant: 383001
fast: false
reversible: false
type: Reaction

387291
stoichiometry: 1.0
species: 741998
type: SpeciesReference

741239
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

377328
stoichiometry: 1.0
species: 741719
type: SpeciesReference

689905
units: 371312
value: 2.16E-15
type: LocalParameter

373278
stoichiometry: 1.0
species: 741299
type: SpeciesReference

387712
stoichiometry: 1.0
species: 741719
type: SpeciesReference

750218
kinetic law: 387748
product: 387736
reactant: 387724
reactant: 387712
fast: false
reversible: true
type: Reaction

373326
stoichiometry: 1.0
species: 741519
type: SpeciesReference

741459
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

387025
local parameters: 690115
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

689640
units: 371312
value: 7.2E-16
type: LocalParameter

742298
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

371481
stoichiometry: 1.0
species: 737579
type: SpeciesReference

689677
units: 371312
value: 1.8E-16
type: LocalParameter

383596
stoichiometry: 1.0
species: 741639
type: SpeciesReference

745798
kinetic law: 377024
product: 377012
product: 377000
reactant: 376988
fast: false
reversible: false
type: Reaction

689904
units: 371397
value: 3.999888E-17
type: LocalParameter

743738
kinetic law: 372156
product: 372144
reactant: 372132
reactant: 372120
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true
type: Reaction

380138
stoichiometry: 1.0
species: 741459
type: SpeciesReference

379945
stoichiometry: 1.0
species: 741219
type: SpeciesReference

375084
local parameters: 689545
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

385879
stoichiometry: 1.0
species: 740979
type: SpeciesReference

741919
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

378417
stoichiometry: 1.0
species: 738879
type: SpeciesReference

376784
local parameters: 689640
local parameters: 689638
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

739939
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741179
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 737339
type: Species

389245
stoichiometry: 1.0
species: 742978
type: SpeciesReference

689601
units: 371312
value: 1.8E-16
type: LocalParameter

375905
local parameters: 689599
local parameters: 689598
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

388899
stoichiometry: 1.0
species: 742318
type: SpeciesReference

742318
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

689575
units: 371312
value: 1.224E-16
type: LocalParameter

739219
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

377364
local parameters: 689667
local parameters: 689665
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

689462
units: 371312
value: 2.25E-16
type: LocalParameter

748538
kinetic law: 383668
product: 383656
reactant: 383644
reactant: 383632
fast: false
reversible: true
type: Reaction

386168
stoichiometry: 1.0
species: 741059
type: SpeciesReference

376880
local parameters: 689644
local parameters: 689643
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

385033
stoichiometry: 1.0
species: 740799
type: SpeciesReference

689676
units: 371312
value: 7.2E-16
type: LocalParameter

747098
kinetic law: 380174
product: 380162
reactant: 380150
reactant: 380138
fast: false
reversible: true
type: Reaction

372699
stoichiometry: 1.0
species: 740159
type: SpeciesReference

689641
units: 371312
value: 1.8E-16
type: LocalParameter

383524
local parameters: 689953
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

742358
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359
type: Species

689363
units: 371397
value: 0.0
type: LocalParameter

689982
units: 371397
value: 8.7498E-18
type: LocalParameter

374854
stoichiometry: 1.0
species: 737739
type: SpeciesReference

382675
stoichiometry: 1.0
species: 740039
type: SpeciesReference

371530
stoichiometry: 1.0
species: 737399
type: SpeciesReference

388159
stoichiometry: 1.0
species: 741819
type: SpeciesReference

748938
kinetic law: 384634
product: 384622
reactant: 384610
reactant: 384597
fast: false
reversible: true
type: Reaction

383802
stoichiometry: 1.0
species: 740379
type: SpeciesReference

388559
stoichiometry: 1.0
species: 742978
type: SpeciesReference

689576
units: 371312
value: 3.06E-17
type: LocalParameter

388099
stoichiometry: 1.0
species: 741719
type: SpeciesReference

371337
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

381551
stoichiometry: 1.0
species: 741799
type: SpeciesReference

748078
kinetic law: 382545
product: 382533
product: 382520
reactant: 382508
fast: false
reversible: false
type: Reaction

375156
stoichiometry: 1.0
species: 740299
type: SpeciesReference

742598
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689461
units: 371312
value: 2.25E-16
type: LocalParameter

739979
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

374938
local parameters: 689539
local parameters: 689537
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

386276
local parameters: 690082
local parameters: 690081
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

689902
units: 371312
value: 5.4E-16
type: LocalParameter

385143
stoichiometry: 1.0
species: 741719
type: SpeciesReference

373097
stoichiometry: 1.0
species: 741519
type: SpeciesReference

742698
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

746578
kinetic law: 378914
product: 378902
reactant: 378890
reactant: 378878
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

689719
units: 371397
value: 2.011824E-17
type: LocalParameter

689983
units: 371312
value: 1.4E-17
type: LocalParameter

374112
local parameters: 689500
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

689573
units: 371397
value: 3.420036E-18
type: LocalParameter

737699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 737339
type: Species

689366
units: 371312
value: 9.0E-17
type: LocalParameter

378357
stoichiometry: 1.0
species: 741579
type: SpeciesReference

373386
stoichiometry: 1.0
species: 741819
type: SpeciesReference

388292
stoichiometry: 1.0
species: 741619
type: SpeciesReference

373435
stoichiometry: 1.0
species: 741799
type: SpeciesReference

379083
stoichiometry: 1.0
species: 738999
type: SpeciesReference

739639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

372590
local parameters: 689396
local parameters: 689395
notes: kf*CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM
type: KineticLaw

384634
local parameters: 690006
local parameters: 690004
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

689674
units: 371397
value: 2.011824E-17
type: LocalParameter

689901
units: 371312
value: 2.16E-15
type: LocalParameter

371867
stoichiometry: 1.0
species: 740259
type: SpeciesReference

385347
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748818
kinetic law: 384345
product: 384333
reactant: 384321
reactant: 384309
fast: false
reversible: true
type: Reaction

689365
units: 371349
value: 3.24008424E-16
type: LocalParameter

746238
kinetic law: 378091
product: 378079
product: 378067
reactant: 378055
fast: false
reversible: false
type: Reaction

376051
local parameters: 689605
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

380439
stoichiometry: 1.0
species: 739239
type: SpeciesReference

379047
stoichiometry: 1.0
species: 738999
type: SpeciesReference

738279
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

738479
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689644
units: 371312
value: 7.2E-16
type: LocalParameter

689467
units: 371312
value: 1.0E-15
type: LocalParameter

381977
stoichiometry: 1.0
species: 741579
type: SpeciesReference

372313
stoichiometry: 1.0
species: 739099
type: SpeciesReference

378672
local parameters: 689727
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

374538
stoichiometry: 1.0
species: 737679
type: SpeciesReference

689605
units: 371312
value: 1.8E-16
type: LocalParameter

381515
stoichiometry: 1.0
species: 739739
type: SpeciesReference

372252
local parameters: 689375
local parameters: 689374
notes: kf*PKA_slash_R2C2*cAMP-kb*PKA_slash_R2C2_minus_cAMP
type: KineticLaw

689368
units: 371349
value: 9.00720324E-13
type: LocalParameter

377460
local parameters: 689671
local parameters: 689670
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

379835
local parameters: 689781
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

375893
stoichiometry: 1.0
species: 738339
type: SpeciesReference

372916
stoichiometry: 1.0
species: 737399
type: SpeciesReference

381020
stoichiometry: 1.0
species: 739239
type: SpeciesReference

379385
stoichiometry: 1.0
species: 739299
type: SpeciesReference

374974
stoichiometry: 1.0
species: 738059
type: SpeciesReference

744478
kinetic law: 373823
product: 373811
reactant: 373799
reactant: 373787
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

739799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376675
stoichiometry: 1.0
species: 738499
type: SpeciesReference

737819
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

739859
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371819
stoichiometry: 1.0
species: 740239
type: SpeciesReference

749998
kinetic law: 387218
product: 387206
product: 387194
reactant: 387182
fast: false
reversible: false
type: Reaction

740539
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377921
stoichiometry: 1.0
species: 738199
type: SpeciesReference

379981
local parameters: 689788
local parameters: 689787
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

689604
units: 371312
value: 7.2E-16
type: LocalParameter

373519
stoichiometry: 1.0
species: 741039
type: SpeciesReference

690168
units: 371397
value: 2.77776E-19
type: LocalParameter

376735
local parameters: 689637
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

689572
units: 371312
value: 3.06E-17
type: LocalParameter

690140
units: 371397
value: 1.99998E-19
type: LocalParameter

689718
units: 371312
value: 1.8E-16
type: LocalParameter

689465
units: 371312
value: 9.0E-15
type: LocalParameter

375568
local parameters: 689567
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

689679
units: 371397
value: 2.011824E-17
type: LocalParameter

738919
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

380475
stoichiometry: 1.0
species: 739519
type: SpeciesReference

738519
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

375941
stoichiometry: 1.0
species: 738199
type: SpeciesReference

384525
stoichiometry: 1.0
species: 740699
type: SpeciesReference

382062
local parameters: 689884
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

386565
stoichiometry: 1.0
species: 741139
type: SpeciesReference

375048
stoichiometry: 1.0
species: 738099
type: SpeciesReference

384297
local parameters: 689989
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

379119
stoichiometry: 1.0
species: 739039
type: SpeciesReference

742558
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00925933333333333
initial amount: NaN
in compartment: 737379
type: Species

689715
units: 371397
value: 2.011824E-17
type: LocalParameter

690143
units: 371312
value: 2.0E-17
type: LocalParameter

374818
stoichiometry: 1.0
species: 742618
type: SpeciesReference

689643
units: 371397
value: 1.8106416E-16
type: LocalParameter

377109
stoichiometry: 1.0
species: 738199
type: SpeciesReference

383487
stoichiometry: 1.0
species: 740479
type: SpeciesReference

380730
stoichiometry: 1.0
species: 739239
type: SpeciesReference

738119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 737339
type: Species

384671
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689464
units: 371312
value: 9.0E-15
type: LocalParameter

386614
stoichiometry: 1.0
species: 737919
type: SpeciesReference

385239
stoichiometry: 1.0
species: 741619
type: SpeciesReference

389109
local parameters: 690202
local parameters: 690200
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

742518
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737339
type: Species

689980
units: 371312
value: 3.5E-18
type: LocalParameter

689369
units: 371312
value: 9.0E-17
type: LocalParameter

689602
units: 371397
value: 1.8106416E-16
type: LocalParameter

382459
stoichiometry: 1.0
species: 741599
type: SpeciesReference

376123
stoichiometry: 1.0
species: 741459
type: SpeciesReference

381443
stoichiometry: 1.0
species: 739719
type: SpeciesReference

372168
stoichiometry: 1.0
species: 737399
type: SpeciesReference

374223
stoichiometry: 1.0
species: 737639
type: SpeciesReference

689570
units: 371312
value: 1.224E-16
type: LocalParameter

690142
units: 371312
value: 8.0E-17
type: LocalParameter

374576
stoichiometry: 1.0
species: 737639
type: SpeciesReference

689716
units: 371312
value: 7.2E-16
type: LocalParameter

377254
stoichiometry: 1.0
species: 738619
type: SpeciesReference

747758
kinetic law: 381769
product: 381757
product: 381745
reactant: 381733
fast: false
reversible: false
type: Reaction

745278
kinetic law: 375761
product: 375749
product: 375737
reactant: 375725
fast: false
reversible: false
type: Reaction

689405
units: 371312
value: 4.5E-16
type: LocalParameter

689558
units: 371312
value: 6.03E-17
type: LocalParameter

689763
units: 371312
value: 8.1E-16
type: LocalParameter

749898
kinetic law: 386977
product: 386965
reactant: 386953
reactant: 386941
fast: false
reversible: true
type: Reaction

743978
kinetic law: 372748
product: 372735
reactant: 372723
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true
type: Reaction

689498
units: 371312
value: 9.0E-16
type: LocalParameter

382723
stoichiometry: 1.0
species: 740019
type: SpeciesReference

379313
stoichiometry: 1.0
species: 739279
type: SpeciesReference

388862
local parameters: 690191
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

386529
local parameters: 690093
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

388752
stoichiometry: 1.0
species: 742978
type: SpeciesReference

379253
local parameters: 689754
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

386650
stoichiometry: 1.0
species: 741998
type: SpeciesReference

384767
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689444
units: 371312
value: 0.0
type: LocalParameter

689724
units: 371397
value: 2.011824E-17
type: LocalParameter

690122
units: 371312
value: 2.4E-16
type: LocalParameter

741499
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741938
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377752
local parameters: 689685
local parameters: 689683
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

383741
stoichiometry: 1.0
species: 740379
type: SpeciesReference

372108
local parameters: 689366
local parameters: 689365
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4
type: KineticLaw

379727
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689557
units: 371312
value: 2.403E-16
type: LocalParameter

380102
stoichiometry: 1.0
species: 741379
type: SpeciesReference

382110
local parameters: 689887
local parameters: 689886
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

689404
units: 371397
value: 6.479838E-14
type: LocalParameter

689764
units: 371397
value: 3.5998992E-16
type: LocalParameter

742998
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

372265
stoichiometry: 1.0
species: 739079
type: SpeciesReference

381491
stoichiometry: 1.0
species: 741639
type: SpeciesReference

741978
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

389197
stoichiometry: 1.0
species: 742378
type: SpeciesReference

384405
stoichiometry: 1.0
species: 741759
type: SpeciesReference

745378
kinetic law: 376002
product: 375990
reactant: 375978
reactant: 375966
fast: false
reversible: true
type: Reaction

387772
stoichiometry: 1.0
species: 741799
type: SpeciesReference

750058
kinetic law: 387363
product: 387351
reactant: 387339
reactant: 387327
fast: false
reversible: true
type: Reaction

376244
local parameters: 689614
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

690123
units: 371312
value: 6.0E-17
type: LocalParameter

741299
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690070
units: 371312
value: 3.5E-18
type: LocalParameter

689619
units: 371312
value: 1.8E-16
type: LocalParameter

384597
stoichiometry: 1.0
species: 741839
type: SpeciesReference

737839
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 737339
type: Species

690188
units: 371397
value: 2.77776E-19
type: LocalParameter

747278
kinetic law: 380609
product: 380596
product: 380584
reactant: 380572
fast: false
reversible: false
type: Reaction

744498
kinetic law: 373871
product: 373859
product: 373847
reactant: 373835
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

747338
kinetic law: 380754
product: 380742
reactant: 380730
reactant: 380718
fast: false
reversible: true
type: Reaction

378575
local parameters: 689722
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

374624
stoichiometry: 1.0
species: 742598
type: SpeciesReference

740459
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

373895
stoichiometry: 1.0
species: 737579
type: SpeciesReference

740519
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374198
stoichiometry: 1.0
species: 737419
type: SpeciesReference

372216
stoichiometry: 1.0
species: 739059
type: SpeciesReference

739779
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690120
units: 371397
value: 9.375E-19
type: LocalParameter

689446
units: 371312
value: 3.24E-21
type: LocalParameter

743938
kinetic law: 372626
product: 372614
reactant: 372602
notes: Random rate.
fast: false
reversible: true
type: Reaction

372373
stoichiometry: 1.0
species: 739119
type: SpeciesReference

371831
local parameters: 689348
local parameters: 689347
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD
type: KineticLaw

381141
local parameters: 689842
local parameters: 689841
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

689407
units: 371312
value: 2.7E-14
type: LocalParameter

745238
kinetic law: 375664
product: 375652
product: 375640
reactant: 375628
fast: false
reversible: false
type: Reaction

689871
units: 371312
value: 5.4E-16
type: LocalParameter

377412
local parameters: 689668
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

744638
kinetic law: 374210
product: 374198
product: 374186
reactant: 374173
fast: false
reversible: false
type: Reaction

750458
kinetic law: 388328
product: 388316
reactant: 388304
reactant: 388292
fast: false
reversible: true
type: Reaction

377158
stoichiometry: 1.0
species: 738599
type: SpeciesReference

689766
units: 371312
value: 2.16E-15
type: LocalParameter

381829
stoichiometry: 1.0
species: 739799
type: SpeciesReference

387435
stoichiometry: 1.0
species: 742938
type: SpeciesReference

381600
stoichiometry: 1.0
species: 739239
type: SpeciesReference

750418
kinetic law: 388232
product: 388220
reactant: 388207
reactant: 388195
fast: false
reversible: true
type: Reaction

383061
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689497
units: 371397
value: 2.2062942E-16
type: LocalParameter

374295
stoichiometry: 1.0
species: 737419
type: SpeciesReference

689725
units: 371312
value: 7.2E-16
type: LocalParameter

384188
stoichiometry: 1.0
species: 740379
type: SpeciesReference

376578
stoichiometry: 1.0
species: 738479
type: SpeciesReference

737799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689447
units: 371312
value: 0.0
type: LocalParameter

737879
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

746918
kinetic law: 379739
product: 379727
product: 379714
reactant: 379702
fast: false
reversible: false
type: Reaction

739039
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

747238
kinetic law: 380512
product: 380500
product: 380488
reactant: 380475
fast: false
reversible: false
type: Reaction

689330
units: 371312
value: 9.0E-18
type: LocalParameter

378309
stoichiometry: 1.0
species: 738199
type: SpeciesReference

377957
stoichiometry: 1.0
species: 738779
type: SpeciesReference

385191
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748438
kinetic law: 383425
product: 383413
product: 383401
reactant: 383389
fast: false
reversible: false
type: Reaction

387375
stoichiometry: 1.0
species: 742019
type: SpeciesReference

378987
stoichiometry: 1.0
species: 738999
type: SpeciesReference

745998
kinetic law: 377508
product: 377496
product: 377484
reactant: 377472
fast: false
reversible: false
type: Reaction

689554
units: 371312
value: 1.8E-16
type: LocalParameter

388268
stoichiometry: 1.0
species: 742978
type: SpeciesReference

690186
units: 371312
value: 2.0E-17
type: LocalParameter

371505
local parameters: 689327
local parameters: 689326
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

382559
stoichiometry: 1.0
species: 742438
type: SpeciesReference

690073
units: 371312
value: 1.4E-17
type: LocalParameter

380863
stoichiometry: 1.0
species: 739599
type: SpeciesReference

376208
stoichiometry: 1.0
species: 738399
type: SpeciesReference

689670
units: 371397
value: 2.011824E-17
type: LocalParameter

690126
units: 371312
value: 2.0E-17
type: LocalParameter

748838
kinetic law: 384393
product: 384381
product: 384369
reactant: 384357
fast: false
reversible: false
type: Reaction

375725
stoichiometry: 1.0
species: 738299
type: SpeciesReference

380524
stoichiometry: 1.0
species: 741399
type: SpeciesReference

373471
stoichiometry: 1.0
species: 741519
type: SpeciesReference

387472
stoichiometry: 1.0
species: 742038
type: SpeciesReference

745838
kinetic law: 377121
product: 377109
product: 377097
reactant: 377085
fast: false
reversible: false
type: Reaction

689509
units: 371312
value: 2.25E-16
type: LocalParameter

740339
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689760
units: 371397
value: 5.99994E-17
type: LocalParameter

383898
stoichiometry: 1.0
species: 740379
type: SpeciesReference

385383
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689332
units: 371349
value: 6.47990604E-15
type: LocalParameter

690187
units: 371312
value: 5.0E-18
type: LocalParameter

377496
stoichiometry: 1.0
species: 738199
type: SpeciesReference

738899
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689671
units: 371312
value: 7.2E-16
type: LocalParameter

689408
units: 371312
value: 2.7E-14
type: LocalParameter

689449
units: 371397
value: 1.08E-19
type: LocalParameter

383413
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689872
units: 371397
value: 3.999888E-17
type: LocalParameter

690127
units: 371312
value: 5.0E-18
type: LocalParameter

375676
stoichiometry: 1.0
species: 740339
type: SpeciesReference

373024
stoichiometry: 1.0
species: 741579
type: SpeciesReference

743939
kinetic law: 372662
product: 372650
reactant: 372638
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true
type: Reaction

750378
kinetic law: 388135
product: 388123
reactant: 388111
reactant: 388099
fast: false
reversible: true
type: Reaction

741979
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689761
units: 371312
value: 3.24E-15
type: LocalParameter

385903
stoichiometry: 1.0
species: 740979
type: SpeciesReference

376928
local parameters: 689646
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

375255
stoichiometry: 1.0
species: 740359
type: SpeciesReference

386120
stoichiometry: 1.0
species: 740379
type: SpeciesReference

385443
stoichiometry: 1.0
species: 740379
type: SpeciesReference

380186
stoichiometry: 1.0
species: 739459
type: SpeciesReference

388704
stoichiometry: 1.0
species: 742278
type: SpeciesReference

374442
stoichiometry: 1.0
species: 737519
type: SpeciesReference

749358
kinetic law: 385648
product: 385636
product: 385623
reactant: 385611
fast: false
reversible: false
type: Reaction

374259
local parameters: 689507
local parameters: 689506
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

749118
kinetic law: 385069
product: 385057
product: 385045
reactant: 385033
fast: false
reversible: false
type: Reaction

376868
stoichiometry: 1.0
species: 738539
type: SpeciesReference

689661
units: 371397
value: 1.8106416E-16
type: LocalParameter

690184
units: 371397
value: 2.77776E-19
type: LocalParameter

380682
stoichiometry: 1.0
species: 741299
type: SpeciesReference

382879
stoichiometry: 1.0
species: 740139
type: SpeciesReference

689333
units: 371312
value: 6.48E-15
type: LocalParameter

371578
stoichiometry: 2.0
species: 737559
type: SpeciesReference

690124
units: 371397
value: 7.8126E-20
type: LocalParameter

689722
units: 371312
value: 1.8E-16
type: LocalParameter

690019
units: 371312
value: 6.8E-18
type: LocalParameter

746058
kinetic law: 377654
product: 377642
reactant: 377630
reactant: 377618
fast: false
reversible: true
type: Reaction

689875
units: 371312
value: 5.4E-16
type: LocalParameter

383208
stoichiometry: 1.0
species: 741619
type: SpeciesReference

384827
local parameters: 690015
local parameters: 690013
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

374890
local parameters: 689536
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

689555
units: 371397
value: 3.0024108E-17
type: LocalParameter

372482
stoichiometry: 1.0
species: 739179
type: SpeciesReference

372796
stoichiometry: 1.0
species: 740359
type: SpeciesReference

385975
stoichiometry: 1.0
species: 740999
type: SpeciesReference

380065
stoichiometry: 1.0
species: 739439
type: SpeciesReference

385431
stoichiometry: 1.0
species: 741819
type: SpeciesReference

747918
kinetic law: 382158
product: 382146
product: 382134
reactant: 382122
fast: false
reversible: false
type: Reaction

690072
units: 371397
value: 8.7498E-18
type: LocalParameter

689673
units: 371312
value: 1.8E-16
type: LocalParameter

749318
kinetic law: 385551
product: 385539
product: 385527
reactant: 385515
fast: false
reversible: false
type: Reaction

388183
local parameters: 690163
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

746478
kinetic law: 378672
product: 378660
product: 378648
reactant: 378636
fast: false
reversible: false
type: Reaction

378466
stoichiometry: 1.0
species: 738199
type: SpeciesReference

741939
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

383450
stoichiometry: 1.0
species: 740379
type: SpeciesReference

374319
stoichiometry: 1.0
species: 737639
type: SpeciesReference

746398
kinetic law: 378478
product: 378466
product: 378454
reactant: 378441
fast: false
reversible: false
type: Reaction

689874
units: 371312
value: 2.16E-15
type: LocalParameter

377569
stoichiometry: 1.0
species: 738699
type: SpeciesReference

689721
units: 371312
value: 7.2E-16
type: LocalParameter

372832
local parameters: 689414
local parameters: 689413
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD
type: KineticLaw

745598
kinetic law: 376542
product: 376530
product: 376518
reactant: 376506
fast: false
reversible: false
type: Reaction

380415
local parameters: 689808
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

689877
units: 371397
value: 3.999888E-17
type: LocalParameter

386819
stoichiometry: 1.0
species: 741859
type: SpeciesReference

689839
units: 371312
value: 5.4E-16
type: LocalParameter

738679
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371614
stoichiometry: 1.0
species: 737959
type: SpeciesReference

386747
stoichiometry: 1.0
species: 741978
type: SpeciesReference

386349
stoichiometry: 1.0
species: 739999
type: SpeciesReference

690182
units: 371312
value: 2.0E-17
type: LocalParameter

741079
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741759
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

386699
stoichiometry: 1.0
species: 741879
type: SpeciesReference

378878
stoichiometry: 1.0
species: 737919
type: SpeciesReference

373678
local parameters: 689474
local parameters: 689473
notes: kf*CaMKII_PSD_slash_basal_CaMKII_PSD_control-kb*CaMKII_PSD_slash_basal_CaMKII_PSD
type: KineticLaw

372433
stoichiometry: 1.0
species: 739159
type: SpeciesReference

384719
stoichiometry: 1.0
species: 740739
type: SpeciesReference

387266
local parameters: 690126
local parameters: 690124
notes: k1*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

377848
local parameters: 689689
local parameters: 689688
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

379884
local parameters: 689784
local parameters: 689782
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

740199
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737379
type: Species

690018
units: 371397
value: 8.7498E-18
type: LocalParameter

375833
stoichiometry: 1.0
species: 741199
type: SpeciesReference

371686
stoichiometry: 1.0
species: 737799
type: SpeciesReference

738959
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373133
stoichiometry: 1.0
species: 741199
type: SpeciesReference

747678
kinetic law: 381575
product: 381563
product: 381551
reactant: 381539
fast: false
reversible: false
type: Reaction

386060
stoichiometry: 1.0
species: 740379
type: SpeciesReference

383244
stoichiometry: 1.0
species: 741619
type: SpeciesReference

747598
kinetic law: 381383
product: 381371
product: 381358
reactant: 381346
fast: false
reversible: false
type: Reaction

738239
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

380572
stoichiometry: 1.0
species: 739539
type: SpeciesReference

378260
stoichiometry: 1.0
species: 741699
type: SpeciesReference

689838
units: 371312
value: 2.16E-15
type: LocalParameter

690183
units: 371312
value: 5.0E-18
type: LocalParameter

374367
stoichiometry: 1.0
species: 737499
type: SpeciesReference

745558
kinetic law: 376446
product: 376434
product: 376422
reactant: 376409
fast: false
reversible: false
type: Reaction

373956
stoichiometry: 1.0
species: 741979
type: SpeciesReference

690078
units: 371312
value: 2.106E-16
type: LocalParameter

387917
stoichiometry: 1.0
species: 742978
type: SpeciesReference

378793
stoichiometry: 1.0
species: 738199
type: SpeciesReference

383922
stoichiometry: 1.0
species: 741739
type: SpeciesReference

383789
stoichiometry: 1.0
species: 741559
type: SpeciesReference

385793
local parameters: 690060
local parameters: 690058
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

375785
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689491
units: 371397
value: 1.08E-20
type: LocalParameter

374698
local parameters: 689527
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

387664
stoichiometry: 1.0
species: 742058
type: SpeciesReference

690015
units: 371312
value: 6.8E-18
type: LocalParameter

690128
units: 371397
value: 3.12498E-19
type: LocalParameter

381419
stoichiometry: 1.0
species: 739719
type: SpeciesReference

381080
stoichiometry: 1.0
species: 739239
type: SpeciesReference

376530
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690180
units: 371397
value: 2.77776E-19
type: LocalParameter

689932
units: 371397
value: 8.7498E-18
type: LocalParameter

739359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690075
units: 371312
value: 3.5E-18
type: LocalParameter

375400
stoichiometry: 1.0
species: 738199
type: SpeciesReference

387580
stoichiometry: 1.0
species: 741998
type: SpeciesReference

380815
stoichiometry: 1.0
species: 741439
type: SpeciesReference

745758
kinetic law: 376928
product: 376916
product: 376904
reactant: 376892
fast: false
reversible: false
type: Reaction

384140
stoichiometry: 1.0
species: 740619
type: SpeciesReference

738639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

740939
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

750638
kinetic law: 388764
product: 388752
product: 388740
reactant: 388728
fast: false
reversible: false
type: Reaction

388595
stoichiometry: 1.0
species: 742978
type: SpeciesReference

386011
stoichiometry: 1.0
species: 741639
type: SpeciesReference

749098
kinetic law: 385021
product: 385009
reactant: 384997
reactant: 384985
fast: false
reversible: true
type: Reaction

689878
units: 371312
value: 2.16E-15
type: LocalParameter

375328
local parameters: 689557
local parameters: 689555
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

376639
local parameters: 689632
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

690016
units: 371312
value: 1.7E-18
type: LocalParameter

689931
units: 371312
value: 9.0E-16
type: LocalParameter

690076
units: 371397
value: 9.180054E-18
type: LocalParameter

383341
stoichiometry: 1.0
species: 741679
type: SpeciesReference

744418
kinetic law: 373678
product: 373666
reactant: 373654
notes: This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations.
fast: false
reversible: true
type: Reaction

380294
stoichiometry: 1.0
species: 741299
type: SpeciesReference

689836
units: 371397
value: 3.999888E-17
type: LocalParameter

385599
local parameters: 690051
local parameters: 690049
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

745018
kinetic law: 375132
product: 375120
reactant: 375108
reactant: 375096
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

385756
stoichiometry: 1.0
species: 741839
type: SpeciesReference

376976
local parameters: 689649
local parameters: 689647
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

374550
local parameters: 689521
local parameters: 689519
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

747058
kinetic law: 380077
product: 380065
reactant: 380053
reactant: 380041
fast: false
reversible: true
type: Reaction

379143
stoichiometry: 1.0
species: 738999
type: SpeciesReference

378152
stoichiometry: 1.0
species: 738819
type: SpeciesReference

384236
stoichiometry: 1.0
species: 740639
type: SpeciesReference

379506
stoichiometry: 1.0
species: 739319
type: SpeciesReference

383850
stoichiometry: 1.0
species: 740559
type: SpeciesReference

382266
stoichiometry: 1.0
species: 741659
type: SpeciesReference

690013
units: 371397
value: 8.7498E-18
type: LocalParameter

384032
stoichiometry: 1.0
species: 740379
type: SpeciesReference

740119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 737339
type: Species

689494
units: 371397
value: 1.08E-20
type: LocalParameter

371385
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

388643
stoichiometry: 1.0
species: 741779
type: SpeciesReference

737539
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

378902
stoichiometry: 1.0
species: 738979
type: SpeciesReference

689767
units: 371312
value: 5.4E-16
type: LocalParameter

689401
units: 371312
value: 9.0E-19
type: LocalParameter

372578
stoichiometry: 1.0
species: 738679
type: SpeciesReference

380210
stoichiometry: 1.0
species: 739239
type: SpeciesReference

379651
stoichiometry: 1.0
species: 741419
type: SpeciesReference

383135
local parameters: 689935
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

373569
local parameters: 689465
local parameters: 689464
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

375496
stoichiometry: 1.0
species: 738199
type: SpeciesReference

377000
stoichiometry: 1.0
species: 741239
type: SpeciesReference

376027
stoichiometry: 1.0
species: 741419
type: SpeciesReference

388449
stoichiometry: 1.0
species: 741579
type: SpeciesReference

384973
local parameters: 690021
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

386312
stoichiometry: 1.0
species: 737819
type: SpeciesReference

689495
units: 371312
value: 0.0
type: LocalParameter

374088
stoichiometry: 1.0
species: 737599
type: SpeciesReference

388972
stoichiometry: 1.0
species: 741739
type: SpeciesReference

388376
local parameters: 690171
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

372723
stoichiometry: 1.0
species: 737539
type: SpeciesReference

742658
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

375218
stoichiometry: 1.0
species: 738139
type: SpeciesReference

378538
stoichiometry: 1.0
species: 738899
type: SpeciesReference

740159
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

379469
stoichiometry: 1.0
species: 739239
type: SpeciesReference

746698
kinetic law: 379204
product: 379192
reactant: 379180
reactant: 379168
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true
type: Reaction

749538
kinetic law: 386084
product: 386072
reactant: 386060
reactant: 386048
fast: false
reversible: true
type: Reaction

382903
stoichiometry: 1.0
species: 740139
type: SpeciesReference

742178
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359
type: Species

737579
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 737339
type: Species

371927
local parameters: 689354
local parameters: 689353
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD
type: KineticLaw

749398
kinetic law: 385744
product: 385732
product: 385720
reactant: 385708
fast: false
reversible: false
type: Reaction

381383
local parameters: 689853
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

689492
units: 371312
value: 0.0
type: LocalParameter

739439
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

386855
stoichiometry: 1.0
species: 741859
type: SpeciesReference

376422
stoichiometry: 1.0
species: 741419
type: SpeciesReference

375182
local parameters: 689549
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

690079
units: 371312
value: 5.22E-17
type: LocalParameter

689769
units: 371397
value: 3.5998992E-16
type: LocalParameter

381298
stoichiometry: 1.0
species: 741539
type: SpeciesReference

743778
kinetic law: 372252
product: 372240
reactant: 372228
reactant: 372216
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true
type: Reaction

377520
stoichiometry: 1.0
species: 741679
type: SpeciesReference

387544
stoichiometry: 1.0
species: 742039
type: SpeciesReference

376358
stoichiometry: 1.0
species: 741379
type: SpeciesReference

377642
stoichiometry: 1.0
species: 738719
type: SpeciesReference

380924
stoichiometry: 1.0
species: 739239
type: SpeciesReference

744798
kinetic law: 374600
product: 374588
product: 374576
reactant: 374563
fast: false
reversible: false
type: Reaction

376820
stoichiometry: 1.0
species: 738199
type: SpeciesReference

384875
local parameters: 690016
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

690012
units: 371312
value: 1.7E-18
type: LocalParameter

748698
kinetic law: 384056
product: 384044
reactant: 384032
reactant: 384019
fast: false
reversible: true
type: Reaction

739479
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371723
stoichiometry: 1.0
species: 737839
type: SpeciesReference

374514
stoichiometry: 1.0
species: 737659
type: SpeciesReference

376280
stoichiometry: 1.0
species: 738419
type: SpeciesReference

742138
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

385081
stoichiometry: 1.0
species: 741819
type: SpeciesReference

746658
kinetic law: 379107
product: 379095
reactant: 379083
reactant: 379071
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

385611
stoichiometry: 1.0
species: 740919
type: SpeciesReference

376494
local parameters: 689626
local parameters: 689625
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

381202
stoichiometry: 1.0
species: 741539
type: SpeciesReference

382831
stoichiometry: 1.0
species: 740079
type: SpeciesReference

689402
units: 371312
value: 0.0
type: LocalParameter

737320
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

748198
kinetic law: 382843
product: 382831
product: 382819
reactant: 382807
fast: false
reversible: false
type: Reaction

737959
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689830
units: 371312
value: 5.4E-16
type: LocalParameter

689937
units: 371397
value: 8.7498E-18
type: LocalParameter

387122
local parameters: 690119
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

374734
stoichiometry: 1.0
species: 737719
type: SpeciesReference

690022
units: 371397
value: 8.7498E-18
type: LocalParameter

383389
stoichiometry: 1.0
species: 740459
type: SpeciesReference

379216
stoichiometry: 1.0
species: 739259
type: SpeciesReference

375108
stoichiometry: 1.0
species: 738059
type: SpeciesReference

381878
stoichiometry: 1.0
species: 741699
type: SpeciesReference

379542
local parameters: 689767
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

746958
kinetic law: 379835
product: 379823
product: 379811
reactant: 379799
fast: false
reversible: false
type: Reaction

372952
stoichiometry: 1.0
species: 741179
type: SpeciesReference

689979
units: 371312
value: 1.4E-17
type: LocalParameter

378648
stoichiometry: 1.0
species: 741659
type: SpeciesReference

744578
kinetic law: 374064
product: 374052
reactant: 374040
reactant: 374028
fast: false
reversible: true
type: Reaction

689658
units: 371312
value: 7.2E-16
type: LocalParameter

737439
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

743558
kinetic law: 371735
product: 371723
reactant: 371711
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

381346
stoichiometry: 1.0
species: 739699
type: SpeciesReference

374148
stoichiometry: 1.0
species: 737459
type: SpeciesReference

386240
stoichiometry: 1.0
species: 737799
type: SpeciesReference

745198
kinetic law: 375568
product: 375556
product: 375544
reactant: 375532
fast: false
reversible: false
type: Reaction

373061
local parameters: 689429
local parameters: 689428
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*Anchor
type: KineticLaw

689938
units: 371312
value: 6.8E-18
type: LocalParameter

740499
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

388924
stoichiometry: 1.0
species: 742318
type: SpeciesReference

690021
units: 371312
value: 1.7E-18
type: LocalParameter

374902
stoichiometry: 1.0
species: 737999
type: SpeciesReference

378091
local parameters: 689700
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

742958
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

372614
stoichiometry: 1.0
species: 739999
type: SpeciesReference

375448
stoichiometry: 1.0
species: 737979
type: SpeciesReference

745658
kinetic law: 376687
product: 376675
reactant: 376663
reactant: 376651
fast: false
reversible: true
type: Reaction

743518
kinetic law: 371650
product: 371638
reactant: 371626
reactant: 371614
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

373350
local parameters: 689450
local parameters: 689449
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_
type: KineticLaw

741579
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689659
units: 371312
value: 1.8E-16
type: LocalParameter

379578
stoichiometry: 1.0
species: 739339
type: SpeciesReference

737999
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376396
local parameters: 689622
local parameters: 689620
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

386469
stoichiometry: 1.0
species: 741119
type: SpeciesReference

386965
stoichiometry: 1.0
species: 741919
type: SpeciesReference

388485
stoichiometry: 1.0
species: 741819
type: SpeciesReference

745338
kinetic law: 375905
product: 375893
reactant: 375881
reactant: 375869
fast: false
reversible: true
type: Reaction

744818
kinetic law: 374649
product: 374637
reactant: 374624
reactant: 374612
fast: false
reversible: true
type: Reaction

737479
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

388812
local parameters: 690190
local parameters: 690188
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

382002
stoichiometry: 1.0
species: 739839
type: SpeciesReference

371975
stoichiometry: 1.0
species: 737999
type: SpeciesReference

384936
stoichiometry: 1.0
species: 740779
type: SpeciesReference

689977
units: 371397
value: 8.7498E-18
type: LocalParameter

747458
kinetic law: 381044
product: 381032
reactant: 381020
reactant: 381008
fast: false
reversible: true
type: Reaction

375291
stoichiometry: 1.0
species: 737819
type: SpeciesReference

380634
stoichiometry: 1.0
species: 739239
type: SpeciesReference

377678
stoichiometry: 1.0
species: 741539
type: SpeciesReference

740419
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

750018
kinetic law: 387266
product: 387254
reactant: 387242
reactant: 387230
fast: false
reversible: true
type: Reaction

738019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

739739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

747378
kinetic law: 380851
product: 380839
reactant: 380827
reactant: 380815
fast: false
reversible: true
type: Reaction

381636
stoichiometry: 1.0
species: 739759
type: SpeciesReference

376458
stoichiometry: 1.0
species: 741399
type: SpeciesReference

382387
stoichiometry: 1.0
species: 739919
type: SpeciesReference

737759
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

747418
kinetic law: 380948
product: 380936
reactant: 380924
reactant: 380912
fast: false
reversible: true
type: Reaction

380972
stoichiometry: 1.0
species: 741359
type: SpeciesReference

379614
stoichiometry: 1.0
species: 741259
type: SpeciesReference

385275
stoichiometry: 1.0
species: 741579
type: SpeciesReference

371300
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

747798
kinetic law: 381866
product: 381854
product: 381842
reactant: 381829
fast: false
reversible: false
type: Reaction

689500
units: 371312
value: 2.25E-16
type: LocalParameter

376171
stoichiometry: 1.0
species: 738199
type: SpeciesReference

380355
stoichiometry: 1.0
species: 739499
type: SpeciesReference

741539
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377800
local parameters: 689686
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

383560
stoichiometry: 1.0
species: 740499
type: SpeciesReference

382988
local parameters: 689929
local parameters: 689928
notes: k1*cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

746438
kinetic law: 378575
product: 378562
product: 378550
reactant: 378538
fast: false
reversible: false
type: Reaction

378841
stoichiometry: 1.0
species: 741599
type: SpeciesReference

381940
stoichiometry: 1.0
species: 741819
type: SpeciesReference

742238
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

746118
kinetic law: 377800
product: 377788
product: 377776
reactant: 377764
fast: false
reversible: false
type: Reaction

689374
units: 371397
value: 4.86E-15
type: LocalParameter

378005
stoichiometry: 1.0
species: 741639
type: SpeciesReference

742098
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359
type: Species

387050
stoichiometry: 1.0
species: 741859
type: SpeciesReference

371650
local parameters: 689336
local parameters: 689335
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3
type: KineticLaw

373787
stoichiometry: 1.0
species: 741978
type: SpeciesReference

739519
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

739699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

386397
stoichiometry: 1.0
species: 741099
type: SpeciesReference

387881
stoichiometry: 1.0
species: 742978
type: SpeciesReference

373920
local parameters: 689489
local parameters: 689488
notes: kf*CaMKII_PSD_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_PSD_slash_NMDAR
type: KineticLaw

384333
stoichiometry: 1.0
species: 740659
type: SpeciesReference

748478
kinetic law: 383524
product: 383511
product: 383499
reactant: 383487
fast: false
reversible: false
type: Reaction

689976
units: 371312
value: 3.5E-18
type: LocalParameter

376305
stoichiometry: 1.0
species: 738419
type: SpeciesReference

744978
kinetic law: 375036
product: 375024
reactant: 375012
reactant: 374999
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

381708
stoichiometry: 1.0
species: 739779
type: SpeciesReference

738859
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

375737
stoichiometry: 1.0
species: 740359
type: SpeciesReference

380318
local parameters: 689803
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

387327
stoichiometry: 1.0
species: 741959
type: SpeciesReference

689835
units: 371312
value: 5.4E-16
type: LocalParameter

746098
kinetic law: 377752
product: 377740
reactant: 377728
reactant: 377715
fast: false
reversible: true
type: Reaction

378757
stoichiometry: 1.0
species: 738199
type: SpeciesReference

374770
stoichiometry: 1.0
species: 737639
type: SpeciesReference

373314
stoichiometry: 1.0
species: 741359
type: SpeciesReference

689934
units: 371312
value: 6.8E-18
type: LocalParameter

387953
stoichiometry: 1.0
species: 742118
type: SpeciesReference

389008
local parameters: 690198
local parameters: 690196
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

387724
stoichiometry: 1.0
species: 742978
type: SpeciesReference

384261
stoichiometry: 1.0
species: 740639
type: SpeciesReference

387013
stoichiometry: 1.0
species: 741859
type: SpeciesReference

382098
stoichiometry: 1.0
species: 739859
type: SpeciesReference

744138
kinetic law: 373109
product: 373097
product: 373085
reactant: 373073
fast: false
reversible: true
type: Reaction

743618
kinetic law: 371879
product: 371867
reactant: 371855
reactant: 371843
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

689973
units: 371397
value: 8.7498E-18
type: LocalParameter

375978
stoichiometry: 1.0
species: 738199
type: SpeciesReference

746018
kinetic law: 377557
product: 377545
reactant: 377533
reactant: 377520
fast: false
reversible: true
type: Reaction

689372
units: 371312
value: 9.0E-17
type: LocalParameter

740379
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 737359
type: Species

738399
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689935
units: 371312
value: 1.7E-18
type: LocalParameter

745878
kinetic law: 377218
product: 377206
product: 377194
reactant: 377182
fast: false
reversible: false
type: Reaction

746798
kinetic law: 379445
product: 379433
product: 379421
reactant: 379409
fast: false
reversible: false
type: Reaction

689832
units: 371397
value: 3.5998992E-16
type: LocalParameter

384441
local parameters: 689997
local parameters: 689995
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

387616
stoichiometry: 1.0
species: 741959
type: SpeciesReference

749218
kinetic law: 385311
product: 385299
reactant: 385287
reactant: 385275
fast: false
reversible: true
type: Reaction

383620
local parameters: 689958
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

373859
stoichiometry: 1.0
species: 742398
type: SpeciesReference

385696
local parameters: 690055
local parameters: 690054
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

382624
stoichiometry: 1.0
species: 737539
type: SpeciesReference

382496
local parameters: 689905
local parameters: 689904
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

380670
stoichiometry: 1.0
species: 739559
type: SpeciesReference

381190
local parameters: 689844
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

689974
units: 371312
value: 1.4E-17
type: LocalParameter

744178
kinetic law: 373193
product: 373181
reactant: 373169
fast: false
reversible: true
type: Reaction

748798
kinetic law: 384297
product: 384285
product: 384273
reactant: 384261
fast: false
reversible: false
type: Reaction

371409
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

689371
units: 371397
value: 5.399946E-14
type: LocalParameter

386929
local parameters: 690111
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

383705
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748878
kinetic law: 384489
product: 384477
product: 384465
reactant: 384453
fast: false
reversible: false
type: Reaction

689833
units: 371312
value: 2.16E-15
type: LocalParameter

381672
local parameters: 689866
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

375376
local parameters: 689558
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

743898
kinetic law: 372542
product: 372530
reactant: 372518
reactant: 372506
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true
type: Reaction

378043
local parameters: 689698
local parameters: 689697
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

380258
stoichiometry: 1.0
species: 739479
type: SpeciesReference

372530
stoichiometry: 1.0
species: 739219
type: SpeciesReference

383305
stoichiometry: 1.0
species: 741539
type: SpeciesReference

378116
stoichiometry: 1.0
species: 738199
type: SpeciesReference

383025
stoichiometry: 1.0
species: 740159
type: SpeciesReference

746758
kinetic law: 379349
product: 379337
product: 379325
reactant: 379313
fast: false
reversible: false
type: Reaction

379763
stoichiometry: 1.0
species: 739239
type: SpeciesReference

372096
stoichiometry: 1.0
species: 738999
type: SpeciesReference

377703
local parameters: 689682
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

386288
stoichiometry: 1.0
species: 741079
type: SpeciesReference

387990
local parameters: 690155
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

386421
stoichiometry: 1.0
species: 741039
type: SpeciesReference

741799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

385155
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748158
kinetic law: 382747
product: 382735
product: 382723
reactant: 382711
fast: false
reversible: false
type: Reaction

375144
stoichiometry: 1.0
species: 738119
type: SpeciesReference

372047
stoichiometry: 1.0
species: 737979
type: SpeciesReference

747018
kinetic law: 379981
product: 379969
reactant: 379957
reactant: 379945
fast: false
reversible: true
type: Reaction

379192
stoichiometry: 1.0
species: 739259
type: SpeciesReference

689650
units: 371312
value: 1.8E-16
type: LocalParameter

740779
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

739259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689378
units: 371312
value: 2.97E-15
type: LocalParameter

689611
units: 371397
value: 1.8106416E-16
type: LocalParameter

378345
stoichiometry: 1.0
species: 738859
type: SpeciesReference

373398
local parameters: 689453
local parameters: 689452
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_
type: KineticLaw

378950
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689971
units: 371312
value: 3.5E-18
type: LocalParameter

374100
stoichiometry: 1.0
species: 737419
type: SpeciesReference

689561
units: 371312
value: 1.224E-16
type: LocalParameter

384622
stoichiometry: 1.0
species: 740719
type: SpeciesReference

373423
stoichiometry: 1.0
species: 741519
type: SpeciesReference

750678
kinetic law: 388862
product: 388850
product: 388837
reactant: 388825
fast: false
reversible: false
type: Reaction

379095
stoichiometry: 1.0
species: 739039
type: SpeciesReference

742398
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 737359
type: Species

385106
stoichiometry: 1.0
species: 740819
type: SpeciesReference

689662
units: 371312
value: 7.2E-16
type: LocalParameter

378600
stoichiometry: 1.0
species: 738199
type: SpeciesReference

749058
kinetic law: 384924
product: 384912
reactant: 384899
reactant: 384887
fast: false
reversible: true
type: Reaction

387218
local parameters: 690123
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

375628
stoichiometry: 1.0
species: 738279
type: SpeciesReference

380427
stoichiometry: 1.0
species: 741379
type: SpeciesReference

739319
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

738999
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689610
units: 371312
value: 1.8E-16
type: LocalParameter

379035
stoichiometry: 1.0
species: 737979
type: SpeciesReference

689377
units: 371397
value: 4.86E-15
type: LocalParameter

389057
local parameters: 690199
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

748118
kinetic law: 382650
modifier: 382637
product: 382624
reactant: 382611
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false
type: Reaction

385335
stoichiometry: 1.0
species: 741539
type: SpeciesReference

747818
kinetic law: 381915
product: 381903
reactant: 381890
reactant: 381878
fast: false
reversible: true
type: Reaction

371879
local parameters: 689351
local parameters: 689350
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD
type: KineticLaw

739299
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

740739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689506
units: 371397
value: 2.2062942E-16
type: LocalParameter

376063
stoichiometry: 1.0
species: 741479
type: SpeciesReference

745718
kinetic law: 376832
product: 376820
product: 376808
reactant: 376796
fast: false
reversible: false
type: Reaction

740679
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689326
units: 371397
value: 4.4999712E-15
type: LocalParameter

377097
stoichiometry: 1.0
species: 741259
type: SpeciesReference

689665
units: 371397
value: 2.011824E-17
type: LocalParameter

383511
stoichiometry: 1.0
species: 740379
type: SpeciesReference

385491
stoichiometry: 1.0
species: 740899
type: SpeciesReference

375072
stoichiometry: 1.0
species: 738059
type: SpeciesReference

385867
stoichiometry: 1.0
species: 740379
type: SpeciesReference

378429
local parameters: 689716
local parameters: 689715
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

689652
units: 371397
value: 1.8106416E-16
type: LocalParameter

379957
stoichiometry: 1.0
species: 739239
type: SpeciesReference

373702
stoichiometry: 1.0
species: 740259
type: SpeciesReference

371493
stoichiometry: 1.0
species: 737599
type: SpeciesReference

389233
stoichiometry: 1.0
species: 741599
type: SpeciesReference

749918
kinetic law: 387025
product: 387013
product: 387001
reactant: 386989
fast: false
reversible: false
type: Reaction

747638
kinetic law: 381479
product: 381467
product: 381455
reactant: 381443
fast: false
reversible: false
type: Reaction

689613
units: 371312
value: 7.2E-16
type: LocalParameter

689563
units: 371312
value: 3.06E-17
type: LocalParameter

376796
stoichiometry: 1.0
species: 738519
type: SpeciesReference

378369
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689507
units: 371312
value: 9.0E-16
type: LocalParameter

382158
local parameters: 689889
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

689770
units: 371312
value: 2.16E-15
type: LocalParameter

689664
units: 371312
value: 1.8E-16
type: LocalParameter

385045
stoichiometry: 1.0
species: 741679
type: SpeciesReference

372687
stoichiometry: 1.0
species: 737399
type: SpeciesReference

689653
units: 371312
value: 7.2E-16
type: LocalParameter

377376
stoichiometry: 1.0
species: 738639
type: SpeciesReference

689450
units: 371312
value: 8.0E-20
type: LocalParameter

385939
local parameters: 690066
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

388547
stoichiometry: 1.0
species: 741839
type: SpeciesReference

382663
stoichiometry: 1.0
species: 737539
type: SpeciesReference

388147
stoichiometry: 1.0
species: 742158
type: SpeciesReference

371542
stoichiometry: 1.0
species: 737619
type: SpeciesReference

383814
local parameters: 689967
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

689970
units: 371312
value: 1.4E-17
type: LocalParameter

747978
kinetic law: 382303
product: 382291
reactant: 382278
reactant: 382266
fast: false
reversible: true
type: Reaction

745058
kinetic law: 375230
product: 375218
reactant: 375206
reactant: 375194
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

689564
units: 371397
value: 3.0779838E-17
type: LocalParameter

738179
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

381563
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689375
units: 371312
value: 2.97E-15
type: LocalParameter

374842
local parameters: 689534
local parameters: 689533
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

749958
kinetic law: 387122
product: 387110
product: 387098
reactant: 387086
fast: false
reversible: false
type: Reaction

383293
stoichiometry: 1.0
species: 740439
type: SpeciesReference

380463
local parameters: 689811
local parameters: 689809
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

689453
units: 371312
value: 8.0E-20
type: LocalParameter

375556
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689501
units: 371397
value: 2.2062942E-16
type: LocalParameter

689667
units: 371312
value: 7.2E-16
type: LocalParameter

750798
kinetic law: 389161
product: 389148
product: 389135
reactant: 389122
fast: false
reversible: false
type: Reaction

379107
local parameters: 689748
local parameters: 689746
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

742019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

375036
local parameters: 689543
local parameters: 689542
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

690131
units: 371312
value: 2.0E-17
type: LocalParameter

689727
units: 371312
value: 1.8E-16
type: LocalParameter

382050
stoichiometry: 1.0
species: 739239
type: SpeciesReference

387808
stoichiometry: 1.0
species: 741679
type: SpeciesReference

384513
stoichiometry: 1.0
species: 740379
type: SpeciesReference

377896
local parameters: 689691
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

376748
stoichiometry: 1.0
species: 741339
type: SpeciesReference

387098
stoichiometry: 1.0
species: 741959
type: SpeciesReference

386602
stoichiometry: 1.0
species: 737859
type: SpeciesReference

385227
stoichiometry: 1.0
species: 740839
type: SpeciesReference

386578
local parameters: 690096
local parameters: 690094
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

380742
stoichiometry: 1.0
species: 739579
type: SpeciesReference

689452
units: 371397
value: 1.08E-19
type: LocalParameter

374806
stoichiometry: 1.0
species: 737599
type: SpeciesReference

383499
stoichiometry: 1.0
species: 741739
type: SpeciesReference

740039
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 737339
type: Species

377788
stoichiometry: 1.0
species: 738199
type: SpeciesReference

742618
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339
type: Species

689655
units: 371312
value: 1.8E-16
type: LocalParameter

746278
kinetic law: 378188
product: 378176
product: 378164
reactant: 378152
fast: false
reversible: false
type: Reaction

380391
stoichiometry: 1.0
species: 741319
type: SpeciesReference

739599
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373241
stoichiometry: 1.0
species: 741319
type: SpeciesReference

689327
units: 371312
value: 4.5E-16
type: LocalParameter

373992
stoichiometry: 1.0
species: 742398
type: SpeciesReference

372156
local parameters: 689369
local parameters: 689368
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

742018
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

743498
kinetic law: 371602
product: 371590
reactant: 371578
reactant: 371566
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

374588
stoichiometry: 1.0
species: 742598
type: SpeciesReference

739199
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 737339
type: Species

689728
units: 371397
value: 2.011824E-17
type: LocalParameter

377266
local parameters: 689662
local parameters: 689661
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

690130
units: 371312
value: 8.0E-17
type: LocalParameter

381455
stoichiometry: 1.0
species: 741799
type: SpeciesReference

750758
kinetic law: 389057
product: 389045
product: 389033
reactant: 389021
fast: false
reversible: false
type: Reaction

737619
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376135
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689614
units: 371312
value: 1.8E-16
type: LocalParameter

382447
local parameters: 689902
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

749578
kinetic law: 386180
product: 386168
reactant: 386156
reactant: 386144
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

378684
stoichiometry: 1.0
species: 741659
type: SpeciesReference

381527
local parameters: 689860
local parameters: 689859
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

741879
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

372325
stoichiometry: 1.0
species: 737539
type: SpeciesReference

689617
units: 371312
value: 7.2E-16
type: LocalParameter

689503
units: 371312
value: 9.0E-16
type: LocalParameter

689656
units: 371397
value: 1.8106416E-16
type: LocalParameter

388038
local parameters: 690158
local parameters: 690156
notes: k1*AMPAR_memb_slash_A_B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

381989
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689455
units: 371397
value: 1.08E-19
type: LocalParameter

381032
stoichiometry: 1.0
species: 739639
type: SpeciesReference

741839
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

742498
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 737339
type: Species

374210
local parameters: 689504
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

372904
stoichiometry: 1.0
species: 737559
type: SpeciesReference

379397
local parameters: 689761
local parameters: 689760
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

379847
stoichiometry: 1.0
species: 741199
type: SpeciesReference

376687
local parameters: 689635
local parameters: 689634
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

379993
stoichiometry: 1.0
species: 739419
type: SpeciesReference

689616
units: 371397
value: 1.8106416E-16
type: LocalParameter

385503
local parameters: 690046
local parameters: 690045
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

689329
units: 371397
value: 9.001692E-14
type: LocalParameter

384489
local parameters: 689998
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

689504
units: 371312
value: 2.25E-16
type: LocalParameter

371457
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

689668
units: 371312
value: 1.8E-16
type: LocalParameter

738319
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689560
units: 371397
value: 3.0779838E-17
type: LocalParameter

374987
local parameters: 689540
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

388220
stoichiometry: 1.0
species: 742178
type: SpeciesReference

386180
local parameters: 690078
local parameters: 690076
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

689345
units: 371312
value: 7.2E-16
type: LocalParameter

738359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

381238
local parameters: 689847
local parameters: 689845
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

689734
units: 371312
value: 7.2E-16
type: LocalParameter

371566
stoichiometry: 1.0
species: 737779
type: SpeciesReference

690007
units: 371312
value: 1.7E-18
type: LocalParameter

376147
local parameters: 689610
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

738299
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

738419
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

385479
stoichiometry: 1.0
species: 740379
type: SpeciesReference

380150
stoichiometry: 1.0
species: 739239
type: SpeciesReference

690196
units: 371397
value: 2.77776E-19
type: LocalParameter

748558
kinetic law: 383717
product: 383705
product: 383693
reactant: 383681
fast: false
reversible: false
type: Reaction

383463
stoichiometry: 1.0
species: 740479
type: SpeciesReference

376482
stoichiometry: 1.0
species: 738459
type: SpeciesReference

376856
stoichiometry: 1.0
species: 738199
type: SpeciesReference

388716
local parameters: 690186
local parameters: 690184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

383536
stoichiometry: 1.0
species: 741799
type: SpeciesReference

380005
stoichiometry: 1.0
species: 741499
type: SpeciesReference

374247
stoichiometry: 1.0
species: 737479
type: SpeciesReference

689773
units: 371397
value: 3.5998992E-16
type: LocalParameter

744018
kinetic law: 372832
product: 372820
product: 372808
reactant: 372796
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

386156
stoichiometry: 1.0
species: 741039
type: SpeciesReference

743878
kinetic law: 372494
product: 372482
product: 372469
reactant: 372457
fast: false
reversible: true
type: Reaction

385915
stoichiometry: 1.0
species: 741739
type: SpeciesReference

384695
stoichiometry: 1.0
species: 741839
type: SpeciesReference

746518
kinetic law: 378769
product: 378757
product: 378744
reactant: 378732
fast: false
reversible: false
type: Reaction

689733
units: 371397
value: 2.011824E-17
type: LocalParameter

382194
stoichiometry: 1.0
species: 739879
type: SpeciesReference

749678
kinetic law: 386433
product: 386421
product: 386409
reactant: 386397
fast: false
reversible: false
type: Reaction

746558
kinetic law: 378865
product: 378853
product: 378841
reactant: 378829
fast: false
reversible: false
type: Reaction

388171
stoichiometry: 1.0
species: 742978
type: SpeciesReference

378478
local parameters: 689718
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

748598
kinetic law: 383814
product: 383802
product: 383789
reactant: 383777
fast: false
reversible: false
type: Reaction

689543
units: 371312
value: 7.50006E-16
type: LocalParameter

375544
stoichiometry: 1.0
species: 738039
type: SpeciesReference

382771
stoichiometry: 1.0
species: 740079
type: SpeciesReference

385818
stoichiometry: 1.0
species: 741799
type: SpeciesReference

740079
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

380536
stoichiometry: 1.0
species: 739239
type: SpeciesReference

739179
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

386204
stoichiometry: 1.0
species: 737819
type: SpeciesReference

386868
stoichiometry: 1.0
species: 741918
type: SpeciesReference

690198
units: 371312
value: 2.0E-17
type: LocalParameter

690009
units: 371397
value: 8.7498E-18
type: LocalParameter

749038
kinetic law: 384875
product: 384863
product: 384851
reactant: 384839
fast: false
reversible: false
type: Reaction

746978
kinetic law: 379884
product: 379872
reactant: 379860
reactant: 379847
fast: false
reversible: true
type: Reaction

744958
kinetic law: 374987
product: 374974
product: 374962
reactant: 374950
fast: false
reversible: false
type: Reaction

689542
units: 371397
value: 5.81256E-17
type: LocalParameter

743458
kinetic law: 371505
product: 371493
reactant: 371481
reactant: 371469
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

387387
stoichiometry: 1.0
species: 741978
type: SpeciesReference

746258
kinetic law: 378140
product: 378128
reactant: 378116
reactant: 378104
fast: false
reversible: true
type: Reaction

385708
stoichiometry: 1.0
species: 740939
type: SpeciesReference

379071
stoichiometry: 1.0
species: 740319
type: SpeciesReference

750718
kinetic law: 388960
product: 388948
product: 388936
reactant: 388924
fast: false
reversible: false
type: Reaction

383425
local parameters: 689949
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

378236
local parameters: 689707
local parameters: 689706
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

689731
units: 371312
value: 1.8E-16
type: LocalParameter

374391
stoichiometry: 1.0
species: 737419
type: SpeciesReference

689344
units: 371349
value: 7.2E-16
type: LocalParameter

377484
stoichiometry: 1.0
species: 741619
type: SpeciesReference

739239
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

374950
stoichiometry: 1.0
species: 738079
type: SpeciesReference

379361
stoichiometry: 1.0
species: 740299
type: SpeciesReference

388655
stoichiometry: 1.0
species: 742978
type: SpeciesReference

741199
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

746598
kinetic law: 378962
product: 378950
product: 378938
reactant: 378926
fast: false
reversible: false
type: Reaction

385371
stoichiometry: 1.0
species: 741839
type: SpeciesReference

690199
units: 371312
value: 5.0E-18
type: LocalParameter

387460
local parameters: 690134
local parameters: 690132
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

744098
kinetic law: 373012
product: 373000
product: 372988
reactant: 372976
fast: false
reversible: true
type: Reaction

375664
local parameters: 689572
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

739139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373532
local parameters: 689462
local parameters: 689461
notes: kf*PKC_minus_control-kb*PKC_minus_active
type: KineticLaw

689772
units: 371312
value: 5.4E-16
type: LocalParameter

375508
stoichiometry: 1.0
species: 738259
type: SpeciesReference

377400
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689809
units: 371397
value: 3.5998992E-16
type: LocalParameter

744398
kinetic law: 373642
product: 373629
reactant: 373617
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true
type: Reaction

739879
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373290
stoichiometry: 1.0
species: 742478
type: SpeciesReference

689341
units: 371312
value: 4.5E-19
type: LocalParameter

745078
kinetic law: 375279
product: 375267
product: 375255
reactant: 375243
fast: false
reversible: false
type: Reaction

376964
stoichiometry: 1.0
species: 738559
type: SpeciesReference

372385
stoichiometry: 1.0
species: 739139
type: SpeciesReference

690156
units: 371397
value: 2.77776E-19
type: LocalParameter

737739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 737339
type: Species

745978
kinetic law: 377460
product: 377448
reactant: 377436
reactant: 377424
fast: false
reversible: true
type: Reaction

371843
stoichiometry: 1.0
species: 740239
type: SpeciesReference

750598
kinetic law: 388667
product: 388655
product: 388643
reactant: 388631
fast: false
reversible: false
type: Reaction

745583
kinetic law: 376494
product: 376482
reactant: 376470
reactant: 376458
fast: false
reversible: true
type: Reaction

690088
units: 371312
value: 3.6E-16
type: LocalParameter

383122
stoichiometry: 1.0
species: 740379
type: SpeciesReference

377908
stoichiometry: 1.0
species: 741739
type: SpeciesReference

689548
units: 371312
value: 7.50006E-16
type: LocalParameter

741699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689808
units: 371312
value: 5.4E-16
type: LocalParameter

387423
stoichiometry: 1.0
species: 741978
type: SpeciesReference

689342
units: 371312
value: 0.0
type: LocalParameter

745938
kinetic law: 377364
product: 377352
reactant: 377340
reactant: 377328
fast: false
reversible: true
type: Reaction

384176
stoichiometry: 1.0
species: 741539
type: SpeciesReference

380803
local parameters: 689826
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

376542
local parameters: 689628
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

689920
units: 371312
value: 7.2E-15
type: LocalParameter

374283
stoichiometry: 1.0
species: 737659
type: SpeciesReference

689737
units: 371397
value: 3.336012E-18
type: LocalParameter

747138
kinetic law: 380270
product: 380258
reactant: 380246
reactant: 380234
fast: false
reversible: true
type: Reaction

690087
units: 371312
value: 1.44E-15
type: LocalParameter

689778
units: 371397
value: 3.5998992E-16
type: LocalParameter

748038
kinetic law: 382447
product: 382435
product: 382423
reactant: 382411
fast: false
reversible: false
type: Reaction

744358
kinetic law: 373569
product: 373556
reactant: 373544
fast: false
reversible: true
type: Reaction

381154
stoichiometry: 1.0
species: 739659
type: SpeciesReference

690116
units: 371397
value: 4.99998E-18
type: LocalParameter

377764
stoichiometry: 1.0
species: 738739
type: SpeciesReference

374830
stoichiometry: 1.0
species: 737739
type: SpeciesReference

375773
stoichiometry: 1.0
species: 741239
type: SpeciesReference

749798
kinetic law: 386735
product: 386723
product: 386711
reactant: 386699
fast: false
reversible: false
type: Reaction

747538
kinetic law: 381238
product: 381226
reactant: 381214
reactant: 381202
fast: false
reversible: true
type: Reaction

747858
kinetic law: 382014
product: 382002
reactant: 381989
reactant: 381977
fast: false
reversible: true
type: Reaction

744678
kinetic law: 374307
product: 374295
product: 374283
reactant: 374271
fast: false
reversible: false
type: Reaction

745178
kinetic law: 375520
product: 375508
reactant: 375496
reactant: 375484
fast: false
reversible: true
type: Reaction

381575
local parameters: 689862
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

383934
stoichiometry: 1.0
species: 740379
type: SpeciesReference

384731
local parameters: 690010
local parameters: 690009
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

689736
units: 371312
value: 1.8E-16
type: LocalParameter

690158
units: 371312
value: 2.0E-17
type: LocalParameter

378272
stoichiometry: 1.0
species: 738199
type: SpeciesReference

739839
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690119
units: 371312
value: 2.0E-18
type: LocalParameter

388764
local parameters: 690187
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

379289
stoichiometry: 1.0
species: 739279
type: SpeciesReference

689775
units: 371312
value: 2.16E-15
type: LocalParameter

689546
units: 371397
value: 6.4584E-18
type: LocalParameter

386072
stoichiometry: 1.0
species: 741019
type: SpeciesReference

738579
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

379325
stoichiometry: 1.0
species: 737999
type: SpeciesReference

741619
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

387278
stoichiometry: 1.0
species: 742018
type: SpeciesReference

738539
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

745618
kinetic law: 376591
product: 376578
reactant: 376566
reactant: 376554
fast: false
reversible: true
type: Reaction

377121
local parameters: 689655
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

379714
stoichiometry: 1.0
species: 741439
type: SpeciesReference

382146
stoichiometry: 1.0
species: 739239
type: SpeciesReference

690159
units: 371312
value: 5.0E-18
type: LocalParameter

375929
stoichiometry: 1.0
species: 741219
type: SpeciesReference

387784
stoichiometry: 1.0
species: 742978
type: SpeciesReference

376256
stoichiometry: 1.0
species: 741499
type: SpeciesReference

372892
stoichiometry: 1.0
species: 737939
type: SpeciesReference

750518
kinetic law: 388473
product: 388461
product: 388449
reactant: 388437
fast: false
reversible: false
type: Reaction

740639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

386711
stoichiometry: 1.0
species: 741979
type: SpeciesReference

389096
stoichiometry: 1.0
species: 742358
type: SpeciesReference

383184
local parameters: 689938
local parameters: 689937
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

386687
local parameters: 690100
local parameters: 690099
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

372844
stoichiometry: 1.0
species: 740319
type: SpeciesReference

389122
stoichiometry: 1.0
species: 742358
type: SpeciesReference

690118
units: 371312
value: 8.0E-18
type: LocalParameter

689776
units: 371312
value: 5.4E-16
type: LocalParameter

372192
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689889
units: 371312
value: 5.4E-16
type: LocalParameter

747898
kinetic law: 382110
product: 382098
reactant: 382086
reactant: 382074
fast: false
reversible: true
type: Reaction

375060
stoichiometry: 1.0
species: 738039
type: SpeciesReference

689545
units: 371312
value: 1.8E-16
type: LocalParameter

374307
local parameters: 689509
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

743718
kinetic law: 372108
product: 372096
reactant: 372084
reactant: 372072
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

689886
units: 371397
value: 3.999888E-17
type: LocalParameter

377557
local parameters: 689676
local parameters: 689674
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

748378
kinetic law: 383280
product: 383268
reactant: 383256
reactant: 383244
fast: false
reversible: true
type: Reaction

376434
stoichiometry: 1.0
species: 738199
type: SpeciesReference

383970
stoichiometry: 1.0
species: 740579
type: SpeciesReference

690084
units: 371312
value: 3.15E-17
type: LocalParameter

385009
stoichiometry: 1.0
species: 740799
type: SpeciesReference

689847
units: 371312
value: 2.16E-15
type: LocalParameter

372784
local parameters: 689411
local parameters: 689410
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4
type: KineticLaw

749458
kinetic law: 385891
product: 385879
reactant: 385867
reactant: 385855
fast: false
reversible: true
type: Reaction

372494
local parameters: 689390
local parameters: 689389
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4
type: KineticLaw

373750
stoichiometry: 1.0
species: 740259
type: SpeciesReference

385963
stoichiometry: 1.0
species: 740379
type: SpeciesReference

371915
stoichiometry: 1.0
species: 737879
type: SpeciesReference

384960
stoichiometry: 1.0
species: 740379
type: SpeciesReference

381262
stoichiometry: 1.0
species: 741619
type: SpeciesReference

742798
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689964
units: 371397
value: 8.7498E-18
type: LocalParameter

382939
local parameters: 689926
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

384815
stoichiometry: 1.0
species: 740759
type: SpeciesReference

689805
units: 371397
value: 3.5998992E-16
type: LocalParameter

742458
notes: This isn\'t explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 737339
type: Species

746338
kinetic law: 378333
product: 378321
reactant: 378309
reactant: 378296
fast: false
reversible: true
type: Reaction

690043
units: 371312
value: 3.5E-18
type: LocalParameter

382843
local parameters: 689922
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

690112
units: 371397
value: 4.99998E-18
type: LocalParameter

689887
units: 371312
value: 2.16E-15
type: LocalParameter

749498
kinetic law: 385987
product: 385975
reactant: 385963
reactant: 385951
fast: false
reversible: true
type: Reaction

689438
units: 371312
value: 0.0
type: LocalParameter

748638
kinetic law: 383910
product: 383898
product: 383886
reactant: 383874
fast: false
reversible: false
type: Reaction

381745
stoichiometry: 1.0
species: 741639
type: SpeciesReference

376292
local parameters: 689617
local parameters: 689616
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

690000
units: 371397
value: 8.7498E-18
type: LocalParameter

374502
local parameters: 689518
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

373605
local parameters: 689468
local parameters: 689467
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

374454
local parameters: 689516
local parameters: 689515
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

377194
stoichiometry: 1.0
species: 741439
type: SpeciesReference

384887
stoichiometry: 1.0
species: 741659
type: SpeciesReference

380912
stoichiometry: 1.0
species: 741479
type: SpeciesReference

742758
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

378055
stoichiometry: 1.0
species: 738799
type: SpeciesReference

743638
kinetic law: 371927
product: 371915
reactant: 371903
reactant: 371891
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

690115
units: 371312
value: 2.0E-18
type: LocalParameter

689437
units: 371312
value: 3.24E-21
type: LocalParameter

689884
units: 371312
value: 5.4E-16
type: LocalParameter

749298
kinetic law: 385503
product: 385491
reactant: 385479
reactant: 385467
fast: false
reversible: true
type: Reaction

372084
stoichiometry: 1.0
species: 738179
type: SpeciesReference

690045
units: 371397
value: 8.7498E-18
type: LocalParameter

378914
local parameters: 689739
local parameters: 689737
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

746718
kinetic law: 379253
product: 379240
product: 379228
reactant: 379216
fast: false
reversible: false
type: Reaction

380222
local parameters: 689799
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

689779
units: 371312
value: 2.16E-15
type: LocalParameter

750238
kinetic law: 387796
product: 387784
product: 387772
reactant: 387760
fast: false
reversible: false
type: Reaction

372638
stoichiometry: 1.0
species: 740079
type: SpeciesReference

749418
kinetic law: 385793
product: 385780
reactant: 385768
reactant: 385756
fast: false
reversible: true
type: Reaction

383074
stoichiometry: 1.0
species: 740399
type: SpeciesReference

690190
units: 371312
value: 2.0E-17
type: LocalParameter

386795
stoichiometry: 1.0
species: 741899
type: SpeciesReference

737639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

383717
local parameters: 689962
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

690001
units: 371312
value: 6.8E-18
type: LocalParameter

384068
stoichiometry: 1.0
species: 740599
type: SpeciesReference

748998
kinetic law: 384779
product: 384767
product: 384755
reactant: 384743
fast: false
reversible: false
type: Reaction

689845
units: 371397
value: 3.999888E-17
type: LocalParameter

383862
local parameters: 689970
local parameters: 689968
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

689962
units: 371312
value: 1.7E-18
type: LocalParameter

740019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

742059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

382254
local parameters: 689893
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

689549
units: 371312
value: 1.8E-16
type: LocalParameter

372735
stoichiometry: 1.0
species: 740199
type: SpeciesReference

379433
stoichiometry: 1.0
species: 739239
type: SpeciesReference

750278
kinetic law: 387893
product: 387881
product: 387869
reactant: 387857
fast: false
reversible: false
type: Reaction

742718
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690046
units: 371312
value: 1.4E-17
type: LocalParameter

381769
local parameters: 689871
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

690114
units: 371312
value: 8.0E-18
type: LocalParameter

388984
stoichiometry: 1.0
species: 742978
type: SpeciesReference

371517
stoichiometry: 1.0
species: 737659
type: SpeciesReference

690085
units: 371397
value: 5.399946E-17
type: LocalParameter

739619
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

374052
stoichiometry: 1.0
species: 737439
type: SpeciesReference

388340
stoichiometry: 1.0
species: 742198
type: SpeciesReference

739559
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376039
stoichiometry: 1.0
species: 738199
type: SpeciesReference

743678
kinetic law: 372011
product: 371999
reactant: 371987
reactant: 371975
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

689844
units: 371312
value: 5.4E-16
type: LocalParameter

378502
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689961
units: 371312
value: 6.8E-18
type: LocalParameter

742058
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

750338
kinetic law: 388038
product: 388026
reactant: 388014
reactant: 388002
fast: false
reversible: true
type: Reaction

743578
kinetic law: 371783
product: 371771
reactant: 371759
reactant: 371747
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

689806
units: 371312
value: 2.16E-15
type: LocalParameter

690191
units: 371312
value: 5.0E-18
type: LocalParameter

375484
stoichiometry: 1.0
species: 738019
type: SpeciesReference

385891
local parameters: 690064
local parameters: 690063
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

377012
stoichiometry: 1.0
species: 738199
type: SpeciesReference

741039
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 737339
type: Species

689435
units: 371397
value: 0.0
type: LocalParameter

374563
stoichiometry: 1.0
species: 737679
type: SpeciesReference

689968
units: 371397
value: 8.7498E-18
type: LocalParameter

690192
units: 371397
value: 2.77776E-19
type: LocalParameter

388063
stoichiometry: 1.0
species: 741559
type: SpeciesReference

381129
stoichiometry: 1.0
species: 739659
type: SpeciesReference

376591
local parameters: 689631
local parameters: 689629
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

690003
units: 371312
value: 1.7E-18
type: LocalParameter

689730
units: 371312
value: 7.2E-16
type: LocalParameter

379131
stoichiometry: 1.0
species: 740299
type: SpeciesReference

378164
stoichiometry: 1.0
species: 741759
type: SpeciesReference

750118
kinetic law: 387508
product: 387496
product: 387484
reactant: 387472
fast: false
reversible: false
type: Reaction

384585
local parameters: 690003
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

689800
units: 371397
value: 3.5998992E-16
type: LocalParameter

382545
local parameters: 689907
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

689434
units: 371312
value: 8.0E-21
type: LocalParameter

689883
units: 371312
value: 2.16E-15
type: LocalParameter

375869
stoichiometry: 1.0
species: 741259
type: SpeciesReference

690040
units: 371397
value: 8.7498E-18
type: LocalParameter

381008
stoichiometry: 1.0
species: 741679
type: SpeciesReference

689967
units: 371312
value: 1.7E-18
type: LocalParameter

748218
kinetic law: 382891
product: 382879
reactant: 382867
reactant: 382855
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true
type: Reaction

385587
stoichiometry: 1.0
species: 740919
type: SpeciesReference

385407
local parameters: 690042
local parameters: 690040
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

374612
stoichiometry: 1.0
species: 737599
type: SpeciesReference

372228
stoichiometry: 1.0
species: 737539
type: SpeciesReference

378587
stoichiometry: 1.0
species: 741839
type: SpeciesReference

690004
units: 371397
value: 8.7498E-18
type: LocalParameter

384200
local parameters: 689985
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

377448
stoichiometry: 1.0
species: 738659
type: SpeciesReference

740599
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689842
units: 371312
value: 2.16E-15
type: LocalParameter

379896
stoichiometry: 1.0
species: 739399
type: SpeciesReference

373205
stoichiometry: 1.0
species: 741339
type: SpeciesReference

377836
stoichiometry: 1.0
species: 738759
type: SpeciesReference

387833
stoichiometry: 1.0
species: 742098
type: SpeciesReference

690082
units: 371312
value: 1.26E-16
type: LocalParameter

373642
local parameters: 689471
local parameters: 689470
notes: kf*AMPAR_bulk-kb*AMPAR_slash_A_B
type: KineticLaw

744738
kinetic law: 374454
product: 374442
reactant: 374429
reactant: 374416
fast: false
reversible: true
type: Reaction

384707
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689880
units: 371312
value: 5.4E-16
type: LocalParameter

387230
stoichiometry: 1.0
species: 741979
type: SpeciesReference

379602
stoichiometry: 1.0
species: 739339
type: SpeciesReference

745698
kinetic law: 376784
product: 376772
reactant: 376760
reactant: 376748
fast: false
reversible: true
type: Reaction

385263
local parameters: 690034
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

690111
units: 371312
value: 2.0E-18
type: LocalParameter

386759
stoichiometry: 1.0
species: 741859
type: SpeciesReference

371626
stoichiometry: 1.0
species: 737559
type: SpeciesReference

749838
kinetic law: 386831
product: 386819
product: 386807
reactant: 386795
fast: false
reversible: false
type: Reaction

689803
units: 371312
value: 5.4E-16
type: LocalParameter

690194
units: 371312
value: 2.0E-17
type: LocalParameter

389161
local parameters: 690203
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

742918
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374661
stoichiometry: 1.0
species: 737699
type: SpeciesReference

689841
units: 371397
value: 3.999888E-17
type: LocalParameter

750198
kinetic law: 387700
product: 387688
product: 387676
reactant: 387664
fast: false
reversible: false
type: Reaction

740979
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

371771
stoichiometry: 1.0
species: 740219
type: SpeciesReference

383753
stoichiometry: 1.0
species: 740539
type: SpeciesReference

383232
local parameters: 689940
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

387845
local parameters: 690150
local parameters: 690148
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

375592
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689881
units: 371397
value: 3.999888E-17
type: LocalParameter

690081
units: 371397
value: 5.507838E-18
type: LocalParameter

384779
local parameters: 690012
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

744778
kinetic law: 374550
product: 374538
reactant: 374526
reactant: 374514
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

741339
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689432
units: 371397
value: 0.0
type: LocalParameter

387905
stoichiometry: 1.0
species: 741619
type: SpeciesReference

689802
units: 371312
value: 2.16E-15
type: LocalParameter

739499
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

380560
local parameters: 689815
local parameters: 689814
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

382735
stoichiometry: 1.0
species: 740039
type: SpeciesReference

690195
units: 371312
value: 5.0E-18
type: LocalParameter

690042
units: 371312
value: 1.4E-17
type: LocalParameter

689965
units: 371312
value: 6.8E-18
type: LocalParameter

378865
local parameters: 689736
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

382038
stoichiometry: 1.0
species: 741759
type: SpeciesReference

742118
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359
type: Species

690006
units: 371312
value: 6.8E-18
type: LocalParameter

373145
stoichiometry: 1.0
species: 741519
type: SpeciesReference

378805
stoichiometry: 1.0
species: 738959
type: SpeciesReference

375845
stoichiometry: 1.0
species: 738199
type: SpeciesReference

750838
kinetic law: 389257
product: 389245
product: 389233
reactant: 389221
fast: false
reversible: false
type: Reaction

740279
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737359
type: Species

748098
kinetic law: 382598
modifier: 382585
product: 382572
reactant: 382559
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false
type: Reaction

746618
kinetic law: 379011
product: 378999
reactant: 378987
reactant: 378974
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

383656
stoichiometry: 1.0
species: 740519
type: SpeciesReference

385660
stoichiometry: 1.0
species: 741599
type: SpeciesReference

689483
units: 371312
value: 1.0E-18
type: LocalParameter

742338
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359
type: Species

388388
stoichiometry: 1.0
species: 741539
type: SpeciesReference

373823
local parameters: 689483
local parameters: 689482
notes: kf*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

376318
stoichiometry: 1.0
species: 741219
type: SpeciesReference

742278
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359
type: Species

743838
kinetic law: 372397
product: 372385
reactant: 372373
reactant: 372361
fast: false
reversible: true
type: Reaction

378393
stoichiometry: 1.0
species: 741699
type: SpeciesReference

746858
kinetic law: 379590
product: 379578
reactant: 379566
reactant: 379554
fast: false
reversible: true
type: Reaction

371469
stoichiometry: 1.0
species: 737399
type: SpeciesReference

748738
kinetic law: 384152
product: 384140
reactant: 384128
reactant: 384116
fast: false
reversible: true
type: Reaction

738459
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689384
units: 371312
value: 2.925E-15
type: LocalParameter

376651
stoichiometry: 1.0
species: 741319
type: SpeciesReference

377303
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689628
units: 371312
value: 1.8E-16
type: LocalParameter

740859
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

375966
stoichiometry: 1.0
species: 741439
type: SpeciesReference

742818
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

378128
stoichiometry: 1.0
species: 738819
type: SpeciesReference

748778
kinetic law: 384249
product: 384236
reactant: 384224
reactant: 384212
fast: false
reversible: true
type: Reaction

383013
stoichiometry: 1.0
species: 740019
type: SpeciesReference

377715
stoichiometry: 1.0
species: 741799
type: SpeciesReference

372566
stoichiometry: 1.0
species: 739959
type: SpeciesReference

379751
stoichiometry: 1.0
species: 741459
type: SpeciesReference

742858
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

740899
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

375340
stoichiometry: 1.0
species: 738219
type: SpeciesReference

384128
stoichiometry: 1.0
species: 740379
type: SpeciesReference

740239
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689482
units: 371397
value: 1.00002E-14
type: LocalParameter

388026
stoichiometry: 1.0
species: 742138
type: SpeciesReference

387194
stoichiometry: 1.0
species: 741958
type: SpeciesReference

738799
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690039
units: 371312
value: 3.5E-18
type: LocalParameter

689443
units: 371312
value: 3.24E-21
type: LocalParameter

381684
stoichiometry: 1.0
species: 741559
type: SpeciesReference

381044
local parameters: 689838
local parameters: 689836
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

379811
stoichiometry: 1.0
species: 741479
type: SpeciesReference

381539
stoichiometry: 1.0
species: 739739
type: SpeciesReference

689629
units: 371397
value: 1.8106416E-16
type: LocalParameter

689890
units: 371397
value: 3.999888E-17
type: LocalParameter

746818
kinetic law: 379494
product: 379481
reactant: 379469
reactant: 379457
fast: false
reversible: true
type: Reaction

689383
units: 371397
value: 6.750054E-15
type: LocalParameter

749638
kinetic law: 386337
product: 386325
product: 386312
product: 386300
reactant: 386288
fast: false
reversible: false
type: Reaction

740179
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373932
stoichiometry: 1.0
species: 737599
type: SpeciesReference

744918
kinetic law: 374890
product: 374878
product: 374866
reactant: 374854
fast: false
reversible: false
type: Reaction

384369
stoichiometry: 1.0
species: 741699
type: SpeciesReference

689626
units: 371312
value: 7.2E-16
type: LocalParameter

746218
kinetic law: 378043
product: 378030
reactant: 378018
reactant: 378005
fast: false
reversible: true
type: Reaction

373980
stoichiometry: 1.0
species: 737619
type: SpeciesReference

373799
stoichiometry: 1.0
species: 740259
type: SpeciesReference

378720
local parameters: 689730
local parameters: 689728
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

386036
local parameters: 690070
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

385623
stoichiometry: 1.0
species: 741699
type: SpeciesReference

377230
stoichiometry: 1.0
species: 741359
type: SpeciesReference

746138
kinetic law: 377848
product: 377836
reactant: 377824
reactant: 377812
fast: false
reversible: true
type: Reaction

373690
stoichiometry: 1.0
species: 741979
type: SpeciesReference

373253
stoichiometry: 1.0
species: 742478
type: SpeciesReference

378224
stoichiometry: 1.0
species: 738839
type: SpeciesReference

371662
stoichiometry: 1.0
species: 737839
type: SpeciesReference

387532
stoichiometry: 1.0
species: 742938
type: SpeciesReference

387086
stoichiometry: 1.0
species: 741938
type: SpeciesReference

385215
local parameters: 690033
local parameters: 690031
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

371735
local parameters: 689342
local parameters: 689341
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin
type: KineticLaw

689386
units: 371312
value: 5.4E-15
type: LocalParameter

738719
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689440
units: 371312
value: 3.24E-21
type: LocalParameter

381952
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689929
units: 371312
value: 3.6E-15
type: LocalParameter

742898
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

744058
kinetic law: 372928
product: 372916
reactant: 372904
reactant: 372892
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

382086
stoichiometry: 1.0
species: 739239
type: SpeciesReference

384501
stoichiometry: 1.0
species: 741699
type: SpeciesReference

386541
stoichiometry: 1.0
species: 737879
type: SpeciesReference

373302
local parameters: 689447
local parameters: 689446
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

689480
units: 371312
value: 0.0
type: LocalParameter

387941
local parameters: 690154
local parameters: 690152
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

387736
stoichiometry: 1.0
species: 742078
type: SpeciesReference

738759
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

375024
stoichiometry: 1.0
species: 738099
type: SpeciesReference

384273
stoichiometry: 1.0
species: 741759
type: SpeciesReference

380306
stoichiometry: 1.0
species: 739239
type: SpeciesReference

746178
kinetic law: 377945
product: 377933
reactant: 377921
reactant: 377908
fast: false
reversible: true
type: Reaction

372409
stoichiometry: 1.0
species: 739139
type: SpeciesReference

380451
stoichiometry: 1.0
species: 739519
type: SpeciesReference

689441
units: 371312
value: 0.0
type: LocalParameter

381648
stoichiometry: 1.0
species: 741739
type: SpeciesReference

750558
kinetic law: 388571
product: 388559
product: 388547
reactant: 388534
fast: false
reversible: false
type: Reaction

382951
stoichiometry: 1.0
species: 737539
type: SpeciesReference

745438
kinetic law: 376147
product: 376135
product: 376123
reactant: 376111
fast: false
reversible: false
type: Reaction

744838
kinetic law: 374698
product: 374686
product: 374674
reactant: 374661
fast: false
reversible: false
type: Reaction

382699
local parameters: 689916
local parameters: 689914
notes: k1*cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

371963
local parameters: 689357
local parameters: 689356
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD
type: KineticLaw

377666
stoichiometry: 1.0
species: 738719
type: SpeciesReference

384924
local parameters: 690019
local parameters: 690018
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

374355
local parameters: 689512
local parameters: 689510
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

377388
stoichiometry: 1.0
species: 741679
type: SpeciesReference

747478
kinetic law: 381093
product: 381080
product: 381068
reactant: 381056
fast: false
reversible: false
type: Reaction

689380
units: 371397
value: 6.750054E-15
type: LocalParameter

382327
stoichiometry: 1.0
species: 741839
type: SpeciesReference

385057
stoichiometry: 1.0
species: 740379
type: SpeciesReference

377606
local parameters: 689677
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

384851
stoichiometry: 1.0
species: 741599
type: SpeciesReference

690036
units: 371397
value: 8.7498E-18
type: LocalParameter

744878
kinetic law: 374794
product: 374782
product: 374770
reactant: 374758
fast: false
reversible: false
type: Reaction

372445
local parameters: 689387
local parameters: 689386
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4
type: KineticLaw

380343
stoichiometry: 1.0
species: 739239
type: SpeciesReference

739399
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689625
units: 371397
value: 1.8106416E-16
type: LocalParameter

389221
stoichiometry: 1.0
species: 742378
type: SpeciesReference

689599
units: 371312
value: 7.2E-16
type: LocalParameter

689512
units: 371312
value: 9.0E-16
type: LocalParameter

380960
stoichiometry: 1.0
species: 739619
type: SpeciesReference

379689
local parameters: 689775
local parameters: 689773
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

745478
kinetic law: 376244
product: 376232
product: 376220
reactant: 376208
fast: false
reversible: false
type: Reaction

380706
local parameters: 689821
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

382399
local parameters: 689901
local parameters: 689899
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

379969
stoichiometry: 1.0
species: 739419
type: SpeciesReference

383172
stoichiometry: 1.0
species: 740419
type: SpeciesReference

381842
stoichiometry: 1.0
species: 741819
type: SpeciesReference

747178
kinetic law: 380367
product: 380355
reactant: 380343
reactant: 380330
fast: false
reversible: true
type: Reaction

372940
stoichiometry: 1.0
species: 741159
type: SpeciesReference

689598
units: 371397
value: 1.8106416E-16
type: LocalParameter

742538
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737359
type: Species

689622
units: 371312
value: 7.2E-16
type: LocalParameter

379023
stoichiometry: 1.0
species: 739019
type: SpeciesReference

389045
stoichiometry: 1.0
species: 742978
type: SpeciesReference

385744
local parameters: 690057
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

379530
stoichiometry: 1.0
species: 739239
type: SpeciesReference

745138
kinetic law: 375424
product: 375412
reactant: 375400
reactant: 375388
fast: false
reversible: true
type: Reaction

387110
stoichiometry: 1.0
species: 741859
type: SpeciesReference

374722
stoichiometry: 1.0
species: 742618
type: SpeciesReference

373411
stoichiometry: 1.0
species: 741319
type: SpeciesReference

381093
local parameters: 689839
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

749758
kinetic law: 386638
product: 386626
product: 386614
product: 386602
reactant: 386590
fast: false
reversible: false
type: Reaction

690010
units: 371312
value: 6.8E-18
type: LocalParameter

383353
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689848
units: 371312
value: 5.4E-16
type: LocalParameter

747578
kinetic law: 381334
product: 381322
reactant: 381310
reactant: 381298
fast: false
reversible: true
type: Reaction

376603
stoichiometry: 1.0
species: 738479
type: SpeciesReference

384997
stoichiometry: 1.0
species: 740379
type: SpeciesReference

382218
stoichiometry: 1.0
species: 739879
type: SpeciesReference

388425
local parameters: 690174
local parameters: 690172
notes: k1*AMPAR_memb_slash_A_B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

384658
stoichiometry: 1.0
species: 741779
type: SpeciesReference

374404
local parameters: 689513
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

386977
local parameters: 690114
local parameters: 690112
notes: k1*CaMKII_PSD_slash_CaMKII_star__star__star__minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

388497
stoichiometry: 1.0
species: 742978
type: SpeciesReference

375436
stoichiometry: 1.0
species: 738239
type: SpeciesReference

689510
units: 371397
value: 2.2062942E-16
type: LocalParameter

388607
stoichiometry: 1.0
species: 742258
type: SpeciesReference

373362
stoichiometry: 1.0
species: 741339
type: SpeciesReference

689623
units: 371312
value: 1.8E-16
type: LocalParameter

689381
units: 371312
value: 9.9E-15
type: LocalParameter

372035
stoichiometry: 1.0
species: 737419
type: SpeciesReference

741659
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

741259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741719
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377594
stoichiometry: 1.0
species: 738199
type: SpeciesReference

388304
stoichiometry: 1.0
species: 742978
type: SpeciesReference

690037
units: 371312
value: 1.4E-17
type: LocalParameter

387676
stoichiometry: 1.0
species: 741978
type: SpeciesReference

374914
stoichiometry: 1.0
species: 738059
type: SpeciesReference

386433
local parameters: 690088
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

381310
stoichiometry: 1.0
species: 739239
type: SpeciesReference

388936
stoichiometry: 1.0
species: 741839
type: SpeciesReference

383317
stoichiometry: 1.0
species: 740379
type: SpeciesReference

379799
stoichiometry: 1.0
species: 739379
type: SpeciesReference

746378
kinetic law: 378429
product: 378417
reactant: 378405
reactant: 378393
fast: false
reversible: true
type: Reaction

373181
stoichiometry: 1.0
species: 742478
type: SpeciesReference

739959
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 737339
type: Species

743758
kinetic law: 372204
product: 372192
reactant: 372180
reactant: 372168
fast: false
reversible: true
type: Reaction

689515
units: 371397
value: 2.2062942E-16
type: LocalParameter

746898
kinetic law: 379689
product: 379676
reactant: 379664
reactant: 379651
fast: false
reversible: true
type: Reaction

745778
kinetic law: 376976
product: 376964
reactant: 376952
reactant: 376940
fast: false
reversible: true
type: Reaction

689620
units: 371397
value: 1.8106416E-16
type: LocalParameter

749198
kinetic law: 385263
product: 385251
product: 385239
reactant: 385227
fast: false
reversible: false
type: Reaction

373036
stoichiometry: 1.0
species: 741419
type: SpeciesReference

378696
stoichiometry: 1.0
species: 738199
type: SpeciesReference

385119
local parameters: 690028
local parameters: 690027
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

739019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

372337
stoichiometry: 1.0
species: 739119
type: SpeciesReference

748958
kinetic law: 384683
product: 384671
product: 384658
reactant: 384646
fast: false
reversible: false
type: Reaction

739919
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376711
stoichiometry: 1.0
species: 741499
type: SpeciesReference

376699
stoichiometry: 1.0
species: 738499
type: SpeciesReference

690164
units: 371397
value: 2.77776E-19
type: LocalParameter

374999
stoichiometry: 1.0
species: 738019
type: SpeciesReference

744518
kinetic law: 373920
product: 373908
product: 373895
reactant: 373883
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes.
fast: false
reversible: true
type: Reaction

380851
local parameters: 689829
local parameters: 689827
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

387628
stoichiometry: 1.0
species: 742938
type: SpeciesReference

689923
units: 371397
value: 1.8900054E-17
type: LocalParameter

388232
local parameters: 690166
local parameters: 690164
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

749158
kinetic law: 385167
product: 385155
product: 385143
reactant: 385131
fast: false
reversible: false
type: Reaction

689516
units: 371312
value: 9.0E-16
type: LocalParameter

384477
stoichiometry: 1.0
species: 740379
type: SpeciesReference

371421
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

385515
stoichiometry: 1.0
species: 740899
type: SpeciesReference

382508
stoichiometry: 1.0
species: 739939
type: SpeciesReference

383681
stoichiometry: 1.0
species: 740519
type: SpeciesReference

377945
local parameters: 689694
local parameters: 689692
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

737679
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 737339
type: Species

374028
stoichiometry: 1.0
species: 737619
type: SpeciesReference

377884
stoichiometry: 1.0
species: 738199
type: SpeciesReference

384549
stoichiometry: 1.0
species: 740699
type: SpeciesReference

387001
stoichiometry: 1.0
species: 741939
type: SpeciesReference

689922
units: 371312
value: 1.8E-15
type: LocalParameter

689739
units: 371312
value: 2.403E-16
type: LocalParameter

377048
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690167
units: 371312
value: 5.0E-18
type: LocalParameter

378018
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689489
units: 371397
value: 5.4E-21
type: LocalParameter

387315
local parameters: 690127
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

744278
kinetic law: 373398
product: 373386
reactant: 373374
reactant: 373362
fast: false
reversible: true
type: Reaction

689513
units: 371312
value: 2.25E-16
type: LocalParameter

379421
stoichiometry: 1.0
species: 740319
type: SpeciesReference

378769
local parameters: 689731
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

388534
stoichiometry: 1.0
species: 742238
type: SpeciesReference

379240
stoichiometry: 1.0
species: 739239
type: SpeciesReference

374173
stoichiometry: 1.0
species: 737459
type: SpeciesReference

739999
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 737339
type: Species

381467
stoichiometry: 1.0
species: 739239
type: SpeciesReference

744238
kinetic law: 373302
product: 373290
reactant: 373278
fast: false
reversible: true
type: Reaction

382435
stoichiometry: 1.0
species: 739239
type: SpeciesReference

387893
local parameters: 690151
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

386361
stoichiometry: 1.0
species: 741039
type: SpeciesReference

377278
stoichiometry: 1.0
species: 738619
type: SpeciesReference

375809
local parameters: 689579
local parameters: 689578
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

738079
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 737339
type: Species

690166
units: 371312
value: 2.0E-17
type: LocalParameter

689488
units: 371312
value: 3.0E-18
type: LocalParameter

689339
units: 371312
value: 9.0E-17
type: LocalParameter

372144
stoichiometry: 1.0
species: 738179
type: SpeciesReference

383280
local parameters: 689943
local parameters: 689941
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

739659
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

380754
local parameters: 689824
local parameters: 689823
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

748338
kinetic law: 383184
product: 383172
reactant: 383160
reactant: 383147
fast: false
reversible: true
type: Reaction

384321
stoichiometry: 1.0
species: 740379
type: SpeciesReference

386638
local parameters: 690097
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

689551
units: 371397
value: 6.4584E-18
type: LocalParameter

382351
local parameters: 689898
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

376183
stoichiometry: 1.0
species: 738399
type: SpeciesReference

739059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 737339
type: Species

379921
stoichiometry: 1.0
species: 739239
type: SpeciesReference

376760
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689782
units: 371397
value: 3.5998992E-16
type: LocalParameter

380041
stoichiometry: 1.0
species: 741419
type: SpeciesReference

383572
local parameters: 689956
local parameters: 689955
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

689519
units: 371397
value: 1.1894364E-17
type: LocalParameter

382650
local parameters: 689913
local parameters: 689911
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

750498
kinetic law: 388425
product: 388412
reactant: 388400
reactant: 388388
fast: false
reversible: true
type: Reaction

737899
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 737359
type: Species

386108
stoichiometry: 1.0
species: 741559
type: SpeciesReference

739099
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373714
stoichiometry: 1.0
species: 741959
type: SpeciesReference

377085
stoichiometry: 1.0
species: 738579
type: SpeciesReference

689338
units: 371397
value: 2.7000216E-17
type: LocalParameter

380114
stoichiometry: 1.0
species: 739239
type: SpeciesReference

388825
stoichiometry: 1.0
species: 742298
type: SpeciesReference

737379
constant: true
size: 5.0E-15
spatial dimensions: 3.0
type: Compartment

689928
units: 371397
value: 1.1339838E-16
type: LocalParameter

738499
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

385551
local parameters: 690048
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

385855
stoichiometry: 1.0
species: 741779
type: SpeciesReference

689387
units: 371397
value: 1.6199838E-15
type: LocalParameter

380791
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689552
units: 371312
value: 7.50006E-16
type: LocalParameter

388075
stoichiometry: 1.0
species: 742978
type: SpeciesReference

374878
stoichiometry: 1.0
species: 742618
type: SpeciesReference

689781
units: 371312
value: 5.4E-16
type: LocalParameter

737339
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

690160
units: 371397
value: 2.77776E-19
type: LocalParameter

388135
local parameters: 690162
local parameters: 690160
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

383826
stoichiometry: 1.0
species: 741799
type: SpeciesReference

380646
stoichiometry: 1.0
species: 739559
type: SpeciesReference

750158
kinetic law: 387604
product: 387592
product: 387580
reactant: 387568
fast: false
reversible: false
type: Reaction

689486
units: 371397
value: 5.4E-21
type: LocalParameter

388874
stoichiometry: 1.0
species: 741799
type: SpeciesReference

377340
stoichiometry: 1.0
species: 738199
type: SpeciesReference

740559
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

384019
stoichiometry: 1.0
species: 741639
type: SpeciesReference

381903
stoichiometry: 1.0
species: 739819
type: SpeciesReference

372675
stoichiometry: 1.0
species: 740119
type: SpeciesReference

744458
kinetic law: 373775
product: 373762
reactant: 373750
reactant: 373738
fast: false
reversible: true
type: Reaction

747318
kinetic law: 380706
product: 380694
product: 380682
reactant: 380670
fast: false
reversible: false
type: Reaction

378962
local parameters: 689740
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

374490
stoichiometry: 1.0
species: 737419
type: SpeciesReference

690163
units: 371312
value: 5.0E-18
type: LocalParameter

741439
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

378333
local parameters: 689712
local parameters: 689710
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

373581
stoichiometry: 1.0
species: 742538
type: SpeciesReference

738939
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

748258
kinetic law: 382988
product: 382975
reactant: 382963
reactant: 382951
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true
type: Reaction

375230
local parameters: 689552
local parameters: 689551
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

387496
stoichiometry: 1.0
species: 742938
type: SpeciesReference

384381
stoichiometry: 1.0
species: 740379
type: SpeciesReference

379180
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689485
units: 371312
value: 3.0E-18
type: LocalParameter

375132
local parameters: 689548
local parameters: 689546
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

374136
stoichiometry: 1.0
species: 737419
type: SpeciesReference

689336
units: 371312
value: 9.0E-16
type: LocalParameter

381358
stoichiometry: 1.0
species: 741679
type: SpeciesReference

750098
kinetic law: 387460
product: 387447
reactant: 387435
reactant: 387423
fast: false
reversible: true
type: Reaction

385167
local parameters: 690030
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

373073
stoichiometry: 1.0
species: 741559
type: SpeciesReference

689926
units: 371312
value: 1.5003E-16
type: LocalParameter

386252
stoichiometry: 1.0
species: 741039
type: SpeciesReference

385323
stoichiometry: 1.0
species: 740859
type: SpeciesReference

689518
units: 371312
value: 2.25E-16
type: LocalParameter

690162
units: 371312
value: 2.0E-17
type: LocalParameter

379204
local parameters: 689752
local parameters: 689751
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

387206
stoichiometry: 1.0
species: 742918
type: SpeciesReference

375616
local parameters: 689570
local parameters: 689569
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

376075
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689389
units: 371312
value: 5.4E-15
type: LocalParameter

741479
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

372988
stoichiometry: 1.0
species: 741459
type: SpeciesReference

387351
stoichiometry: 1.0
species: 742019
type: SpeciesReference

378612
stoichiometry: 1.0
species: 738919
type: SpeciesReference

387158
stoichiometry: 1.0
species: 741999
type: SpeciesReference

373459
stoichiometry: 1.0
species: 741299
type: SpeciesReference

689335
units: 371397
value: 3.2400162E-16
type: LocalParameter

384610
stoichiometry: 1.0
species: 740379
type: SpeciesReference

382611
stoichiometry: 1.0
species: 742438
type: SpeciesReference

371288
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

738139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 737339
type: Species

377993
local parameters: 689695
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

689698
units: 371312
value: 7.2E-16
type: LocalParameter

689925
units: 371312
value: 6.003E-16
type: LocalParameter

689706
units: 371397
value: 2.011824E-17
type: LocalParameter

386216
stoichiometry: 1.0
species: 741039
type: SpeciesReference

689694
units: 371312
value: 7.2E-16
type: LocalParameter

741099
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 737339
type: Species

373495
local parameters: 689459
local parameters: 689458
notes: kf*AMPAR_slash_A845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_
type: KineticLaw

738159
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 737339
type: Species

373507
stoichiometry: 1.0
species: 742498
type: SpeciesReference

741918
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

380548
stoichiometry: 1.0
species: 739539
type: SpeciesReference

689530
units: 371312
value: 2.16E-15
type: LocalParameter

740659
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

387399
stoichiometry: 1.0
species: 742918
type: SpeciesReference

750698
kinetic law: 388912
product: 388899
reactant: 388886
reactant: 388874
fast: false
reversible: true
type: Reaction

743958
kinetic law: 372711
product: 372699
reactant: 372687
reactant: 372675
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true
type: Reaction

747738
kinetic law: 381721
product: 381708
reactant: 381696
reactant: 381684
fast: false
reversible: true
type: Reaction

741219
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

738259
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

738219
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

749718
kinetic law: 386529
product: 386517
product: 386505
reactant: 386493
fast: false
reversible: false
type: Reaction

742578
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

372928
local parameters: 689420
local parameters: 689419
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4
type: KineticLaw

377472
stoichiometry: 1.0
species: 738659
type: SpeciesReference

742978
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

374962
stoichiometry: 1.0
species: 737979
type: SpeciesReference

379373
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689695
units: 371312
value: 1.8E-16
type: LocalParameter

383437
stoichiometry: 1.0
species: 741799
type: SpeciesReference

379168
stoichiometry: 1.0
species: 740039
type: SpeciesReference

378248
stoichiometry: 1.0
species: 738839
type: SpeciesReference

375700
stoichiometry: 1.0
species: 738299
type: SpeciesReference

750078
kinetic law: 387411
product: 387399
product: 387387
reactant: 387375
fast: false
reversible: false
type: Reaction

689743
units: 371312
value: 1.224E-17
type: LocalParameter

373000
stoichiometry: 1.0
species: 741519
type: SpeciesReference

689356
units: 371312
value: 5.0E-20
type: LocalParameter

378660
stoichiometry: 1.0
species: 738199
type: SpeciesReference

741958
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

380609
local parameters: 689817
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

372301
local parameters: 689378
local parameters: 689377
notes: kf*PKA_slash_R2C2_minus_cAMP*cAMP-kb*PKA_slash_R2C2_minus_cAMP2
type: KineticLaw

373544
stoichiometry: 1.0
species: 742518
type: SpeciesReference

375652
stoichiometry: 1.0
species: 738199
type: SpeciesReference

743998
kinetic law: 372784
product: 372772
reactant: 372760
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

374649
local parameters: 689525
local parameters: 689524
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

689784
units: 371312
value: 2.16E-15
type: LocalParameter

388667
local parameters: 690183
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

380162
stoichiometry: 1.0
species: 739459
type: SpeciesReference

689704
units: 371312
value: 1.8E-16
type: LocalParameter

385467
stoichiometry: 1.0
species: 741779
type: SpeciesReference

376470
stoichiometry: 1.0
species: 738199
type: SpeciesReference

386192
stoichiometry: 1.0
species: 741059
type: SpeciesReference

689746
units: 371397
value: 3.420036E-19
type: LocalParameter

747078
kinetic law: 380126
product: 380114
product: 380102
reactant: 380089
fast: false
reversible: false
type: Reaction

743918
kinetic law: 372590
product: 372578
reactant: 372566
reactant: 372554
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true
type: Reaction

386481
local parameters: 690091
local parameters: 690090
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

744438
kinetic law: 373726
product: 373714
product: 373702
reactant: 373690
fast: false
reversible: true
type: Reaction

689357
units: 371312
value: 0.0
type: LocalParameter

381226
stoichiometry: 1.0
species: 739679
type: SpeciesReference

371554
local parameters: 689330
local parameters: 689329
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

381431
local parameters: 689856
local parameters: 689854
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

689851
units: 371312
value: 2.16E-15
type: LocalParameter

690148
units: 371397
value: 2.77776E-19
type: LocalParameter

376159
stoichiometry: 1.0
species: 741279
type: SpeciesReference

750658
kinetic law: 388812
product: 388800
reactant: 388788
reactant: 388776
fast: false
reversible: true
type: Reaction

386144
stoichiometry: 1.0
species: 737839
type: SpeciesReference

742378
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

690109
units: 371312
value: 8.0E-18
type: LocalParameter

385927
stoichiometry: 1.0
species: 740379
type: SpeciesReference

384683
local parameters: 690007
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

739759
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

745038
kinetic law: 375182
product: 375169
product: 375156
reactant: 375144
fast: false
reversible: false
type: Reaction

375279
local parameters: 689554
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

749078
kinetic law: 384973
product: 384960
product: 384948
reactant: 384936
fast: false
reversible: false
type: Reaction

384104
local parameters: 689980
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

741119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

383475
local parameters: 689952
local parameters: 689950
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

376844
stoichiometry: 1.0
species: 741359
type: SpeciesReference

380017
stoichiometry: 1.0
species: 739239
type: SpeciesReference

380948
local parameters: 689833
local parameters: 689832
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

388728
stoichiometry: 1.0
species: 742278
type: SpeciesReference

383548
stoichiometry: 1.0
species: 740379
type: SpeciesReference

376904
stoichiometry: 1.0
species: 741399
type: SpeciesReference

389135
stoichiometry: 1.0
species: 741659
type: SpeciesReference

748058
kinetic law: 382496
product: 382484
reactant: 382471
reactant: 382459
fast: false
reversible: true
type: Reaction

374235
stoichiometry: 1.0
species: 737419
type: SpeciesReference

689785
units: 371312
value: 5.4E-16
type: LocalParameter

375532
stoichiometry: 1.0
species: 738259
type: SpeciesReference

750618
kinetic law: 388716
product: 388704
reactant: 388691
reactant: 388679
fast: false
reversible: true
type: Reaction

689745
units: 371312
value: 3.06E-18
type: LocalParameter

382182
stoichiometry: 1.0
species: 739239
type: SpeciesReference

380888
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689697
units: 371397
value: 2.011824E-17
type: LocalParameter

689850
units: 371397
value: 3.999888E-17
type: LocalParameter

690108
units: 371397
value: 4.99998E-18
type: LocalParameter

741159
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 737359
type: Species

385806
stoichiometry: 1.0
species: 740959
type: SpeciesReference

689531
units: 371312
value: 5.4E-16
type: LocalParameter

689703
units: 371312
value: 7.2E-16
type: LocalParameter

380089
stoichiometry: 1.0
species: 739439
type: SpeciesReference

385999
stoichiometry: 1.0
species: 740999
type: SpeciesReference

747038
kinetic law: 380029
product: 380017
product: 380005
reactant: 379993
fast: false
reversible: false
type: Reaction

382783
stoichiometry: 1.0
species: 740099
type: SpeciesReference

742638
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 737339
type: Species

381587
stoichiometry: 1.0
species: 741559
type: SpeciesReference

383946
stoichiometry: 1.0
species: 740579
type: SpeciesReference

384743
stoichiometry: 1.0
species: 740739
type: SpeciesReference

690146
units: 371312
value: 2.0E-17
type: LocalParameter

689468
units: 371312
value: 1.0E-15
type: LocalParameter

689351
units: 371312
value: 1.0E-16
type: LocalParameter

377776
stoichiometry: 1.0
species: 741739
type: SpeciesReference

689429
units: 371397
value: 0.0
type: LocalParameter

375761
local parameters: 689576
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

689787
units: 371397
value: 3.5998992E-16
type: LocalParameter

379277
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689534
units: 371312
value: 1.8E-16
type: LocalParameter

379337
stoichiometry: 1.0
species: 739239
type: SpeciesReference

386084
local parameters: 690073
local parameters: 690072
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

383268
stoichiometry: 1.0
species: 740439
type: SpeciesReference

380596
stoichiometry: 1.0
species: 739239
type: SpeciesReference

378284
local parameters: 689709
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

748418
kinetic law: 383377
product: 383365
reactant: 383353
reactant: 383341
fast: false
reversible: true
type: Reaction

689748
units: 371312
value: 1.224E-17
type: LocalParameter

376892
stoichiometry: 1.0
species: 738539
type: SpeciesReference

388776
stoichiometry: 1.0
species: 741579
type: SpeciesReference

386675
stoichiometry: 1.0
species: 741879
type: SpeciesReference

742639
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339
type: Species

737519
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

375917
stoichiometry: 1.0
species: 738339
type: SpeciesReference

376268
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690147
units: 371312
value: 5.0E-18
type: LocalParameter

387796
local parameters: 690147
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

740139
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

372289
stoichiometry: 1.0
species: 739099
type: SpeciesReference

689691
units: 371312
value: 1.8E-16
type: LocalParameter

382134
stoichiometry: 1.0
species: 741699
type: SpeciesReference

742678
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689709
units: 371312
value: 1.8E-16
type: LocalParameter

379702
stoichiometry: 1.0
species: 739359
type: SpeciesReference

689428
units: 371312
value: 8.0E-21
type: LocalParameter

690106
units: 371312
value: 2.0E-18
type: LocalParameter

372856
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689788
units: 371312
value: 2.16E-15
type: LocalParameter

378405
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689533
units: 371397
value: 6.428808E-19
type: LocalParameter

372880
local parameters: 689417
local parameters: 689416
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

383196
stoichiometry: 1.0
species: 740419
type: SpeciesReference

745818
kinetic law: 377073
product: 377061
reactant: 377048
reactant: 377036
fast: false
reversible: true
type: Reaction

372180
stoichiometry: 1.0
species: 738999
type: SpeciesReference

386723
stoichiometry: 1.0
species: 741859
type: SpeciesReference

376952
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690144
units: 371397
value: 2.77776E-19
type: LocalParameter

372397
local parameters: 689384
local parameters: 689383
notes: kf*cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4
type: KineticLaw

373871
local parameters: 689486
local parameters: 689485
notes: kf*CaMKII_PSD_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_PSD_slash_NMDAR
type: KineticLaw

371855
stoichiometry: 1.0
species: 740279
type: SpeciesReference

377134
stoichiometry: 1.0
species: 741339
type: SpeciesReference

689692
units: 371397
value: 2.011824E-17
type: LocalParameter

737599
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689353
units: 371397
value: 3.0E-18
type: LocalParameter

690105
units: 371312
value: 8.0E-18
type: LocalParameter

376331
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689536
units: 371312
value: 4.5E-17
type: LocalParameter

748518
kinetic law: 383620
product: 383608
product: 383596
reactant: 383584
fast: false
reversible: false
type: Reaction

749138
kinetic law: 385119
product: 385106
reactant: 385094
reactant: 385081
fast: false
reversible: true
type: Reaction

384092
stoichiometry: 1.0
species: 740379
type: SpeciesReference

389083
stoichiometry: 1.0
species: 742978
type: SpeciesReference

380270
local parameters: 689802
local parameters: 689800
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

383110
stoichiometry: 1.0
species: 741679
type: SpeciesReference

384164
stoichiometry: 1.0
species: 740619
type: SpeciesReference

377291
stoichiometry: 1.0
species: 741479
type: SpeciesReference

747938
kinetic law: 382206
product: 382194
reactant: 382182
reactant: 382170
fast: false
reversible: true
type: Reaction

387411
local parameters: 690131
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

689354
units: 371312
value: 1.0E-17
type: LocalParameter

746458
kinetic law: 378624
product: 378612
reactant: 378600
reactant: 378587
fast: false
reversible: true
type: Reaction

689707
units: 371312
value: 7.2E-16
type: LocalParameter

371590
stoichiometry: 1.0
species: 737959
type: SpeciesReference

385131
stoichiometry: 1.0
species: 740819
type: SpeciesReference

381166
stoichiometry: 1.0
species: 741719
type: SpeciesReference

748498
kinetic law: 383572
product: 383560
reactant: 383548
reactant: 383536
fast: false
reversible: true
type: Reaction

381805
stoichiometry: 1.0
species: 739799
type: SpeciesReference

378550
stoichiometry: 1.0
species: 741779
type: SpeciesReference

376554
stoichiometry: 1.0
species: 741299
type: SpeciesReference

689749
units: 371312
value: 3.06E-18
type: LocalParameter

374271
stoichiometry: 1.0
species: 737479
type: SpeciesReference

372518
stoichiometry: 1.0
species: 739199
type: SpeciesReference

690099
units: 371397
value: 4.99998E-18
type: LocalParameter

372626
local parameters: 689399
local parameters: 689398
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2
type: KineticLaw

383086
local parameters: 689934
local parameters: 689932
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

741279
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

378067
stoichiometry: 1.0
species: 741559
type: SpeciesReference

380234
stoichiometry: 1.0
species: 741279
type: SpeciesReference

382242
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689896
units: 371312
value: 2.16E-15
type: LocalParameter

372120
stoichiometry: 1.0
species: 738159
type: SpeciesReference

689425
units: 371312
value: 8.0E-21
type: LocalParameter

378926
stoichiometry: 1.0
species: 738979
type: SpeciesReference

690103
units: 371397
value: 4.99998E-18
type: LocalParameter

690057
units: 371312
value: 3.5E-18
type: LocalParameter

372072
stoichiometry: 2.0
species: 737559
type: SpeciesReference

383874
stoichiometry: 1.0
species: 740559
type: SpeciesReference

741739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

738659
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boundary condition: false
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initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

371891
stoichiometry: 1.0
species: 737899
type: SpeciesReference

689950
units: 371397
value: 8.7498E-18
type: LocalParameter

386783
local parameters: 690105
local parameters: 690103
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

383729
stoichiometry: 1.0
species: 741639
type: SpeciesReference

689857
units: 371312
value: 5.4E-16
type: LocalParameter

384056
local parameters: 689979
local parameters: 689977
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

388996
stoichiometry: 1.0
species: 742338
type: SpeciesReference

380500
stoichiometry: 1.0
species: 739239
type: SpeciesReference

690097
units: 371312
value: 3.15E-17
type: LocalParameter

388352
stoichiometry: 1.0
species: 741699
type: SpeciesReference

374064
local parameters: 689498
local parameters: 689497
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

738039
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

379676
stoichiometry: 1.0
species: 739359
type: SpeciesReference

689537
units: 371397
value: 5.81256E-17
type: LocalParameter

379445
local parameters: 689763
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

381757
stoichiometry: 1.0
species: 739239
type: SpeciesReference

690058
units: 371397
value: 8.7498E-18
type: LocalParameter

388691
stoichiometry: 1.0
species: 742978
type: SpeciesReference

738699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

378514
stoichiometry: 1.0
species: 738899
type: SpeciesReference

690102
units: 371312
value: 2.0E-18
type: LocalParameter

689818
units: 371397
value: 3.5998992E-16
type: LocalParameter

375472
local parameters: 689563
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

377024
local parameters: 689650
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

377691
stoichiometry: 1.0
species: 738199
type: SpeciesReference

747198
kinetic law: 380415
product: 380403
product: 380391
reactant: 380379
fast: false
reversible: false
type: Reaction

745298
kinetic law: 375809
product: 375797
reactant: 375785
reactant: 375773
fast: false
reversible: true
type: Reaction

689578
units: 371397
value: 1.8106416E-16
type: LocalParameter

738979
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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

747658
kinetic law: 381527
product: 381515
reactant: 381503
reactant: 381491
fast: false
reversible: true
type: Reaction

689856
units: 371312
value: 2.16E-15
type: LocalParameter

738619
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

386831
local parameters: 690106
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

372748
local parameters: 689408
local parameters: 689407
notes: kf*cAMP-kb*AC_slash_cAMP_in_dend
type: KineticLaw

383982
stoichiometry: 1.0
species: 741679
type: SpeciesReference

690096
units: 371312
value: 1.26E-16
type: LocalParameter

373762
stoichiometry: 1.0
species: 741979
type: SpeciesReference

740919
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689859
units: 371397
value: 3.999888E-17
type: LocalParameter

747258
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product: 380548
reactant: 380536
reactant: 380524
fast: false
reversible: true
type: Reaction

689898
units: 371312
value: 5.4E-16
type: LocalParameter

382927
stoichiometry: 1.0
species: 740119
type: SpeciesReference

381274
stoichiometry: 1.0
species: 739239
type: SpeciesReference

384803
stoichiometry: 1.0
species: 740379
type: SpeciesReference

744618
kinetic law: 374161
product: 374148
reactant: 374136
reactant: 374124
fast: false
reversible: true
type: Reaction

377545
stoichiometry: 1.0
species: 738699
type: SpeciesReference

745738
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product: 376868
reactant: 376856
reactant: 376844
fast: false
reversible: true
type: Reaction

745218
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product: 375604
reactant: 375592
reactant: 375580
fast: false
reversible: true
type: Reaction

689952
units: 371312
value: 6.8E-18
type: LocalParameter

689817
units: 371312
value: 5.4E-16
type: LocalParameter

690055
units: 371312
value: 1.4E-17
type: LocalParameter

385951
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species: 741659
type: SpeciesReference

372772
stoichiometry: 1.0
species: 737399
type: SpeciesReference

371903
stoichiometry: 1.0
species: 737859
type: SpeciesReference

376446
local parameters: 689623
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

689579
units: 371312
value: 7.2E-16
type: LocalParameter

378441
stoichiometry: 1.0
species: 738879
type: SpeciesReference

748918
kinetic law: 384585
product: 384573
product: 384561
reactant: 384549
fast: false
reversible: false
type: Reaction

374466
stoichiometry: 1.0
species: 737519
type: SpeciesReference

750438
kinetic law: 388280
product: 388268
product: 388256
reactant: 388244
fast: false
reversible: false
type: Reaction

382855
stoichiometry: 1.0
species: 737539
type: SpeciesReference

690100
units: 371312
value: 8.0E-18
type: LocalParameter

689899
units: 371397
value: 3.999888E-17
type: LocalParameter

387568
stoichiometry: 1.0
species: 742039
type: SpeciesReference

689426
units: 371397
value: 0.0
type: LocalParameter

737399
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

381733
stoichiometry: 1.0
species: 739779
type: SpeciesReference

689350
units: 371397
value: 4.65012E-18
type: LocalParameter

689539
units: 371312
value: 7.50006E-16
type: LocalParameter

377508
local parameters: 689673
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

737859
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 737359
type: Species

377182
stoichiometry: 1.0
species: 738599
type: SpeciesReference

373617
stoichiometry: 1.0
species: 742558
type: SpeciesReference

384899
stoichiometry: 1.0
species: 740379
type: SpeciesReference

745418
kinetic law: 376099
product: 376087
reactant: 376075
reactant: 376063
fast: false
reversible: true
type: Reaction

380900
local parameters: 689830
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

376220
stoichiometry: 1.0
species: 741199
type: SpeciesReference

385251
stoichiometry: 1.0
species: 740379
type: SpeciesReference

373217
stoichiometry: 1.0
species: 742478
type: SpeciesReference

380379
stoichiometry: 1.0
species: 739499
type: SpeciesReference

689892
units: 371312
value: 2.16E-15
type: LocalParameter

387242
stoichiometry: 1.0
species: 742918
type: SpeciesReference

377824
stoichiometry: 1.0
species: 738199
type: SpeciesReference

373654
stoichiometry: 1.0
species: 742578
type: SpeciesReference

690094
units: 371397
value: 6.11982E-19
type: LocalParameter

689740
units: 371312
value: 6.03E-17
type: LocalParameter

689853
units: 371312
value: 5.4E-16
type: LocalParameter

376099
local parameters: 689608
local parameters: 689607
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

375303
stoichiometry: 1.0
species: 738199
type: SpeciesReference

748298
kinetic law: 383086
product: 383074
reactant: 383061
reactant: 383049
fast: false
reversible: true
type: Reaction

371783
local parameters: 689345
local parameters: 689344
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

744218
kinetic law: 373266
product: 373253
reactant: 373241
fast: false
reversible: true
type: Reaction

371638
stoichiometry: 1.0
species: 737939
type: SpeciesReference

689815
units: 371312
value: 2.16E-15
type: LocalParameter

389173
stoichiometry: 1.0
species: 741559
type: SpeciesReference

380996
local parameters: 689835
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

381793
stoichiometry: 1.0
species: 739239
type: SpeciesReference

379481
stoichiometry: 1.0
species: 739319
type: SpeciesReference

383220
stoichiometry: 1.0
species: 740379
type: SpeciesReference

373157
local parameters: 689435
local parameters: 689434
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*Anchor
type: KineticLaw

689420
units: 371312
value: 9.0E-16
type: LocalParameter

387820
stoichiometry: 1.0
species: 742978
type: SpeciesReference

387857
stoichiometry: 1.0
species: 742098
type: SpeciesReference

375580
stoichiometry: 1.0
species: 740319
type: SpeciesReference

383765
local parameters: 689965
local parameters: 689964
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

690093
units: 371312
value: 5.22E-17
type: LocalParameter

689893
units: 371312
value: 5.4E-16
type: LocalParameter

374674
stoichiometry: 1.0
species: 737619
type: SpeciesReference

750398
kinetic law: 388183
product: 388171
product: 388159
reactant: 388147
fast: false
reversible: false
type: Reaction

378817
local parameters: 689734
local parameters: 689733
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

375857
local parameters: 689581
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

371999
stoichiometry: 1.0
species: 738019
type: SpeciesReference

690054
units: 371397
value: 8.7498E-18
type: LocalParameter

689814
units: 371397
value: 3.5998992E-16
type: LocalParameter

382026
stoichiometry: 1.0
species: 739839
type: SpeciesReference

382747
local parameters: 689917
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

689953
units: 371312
value: 1.7E-18
type: LocalParameter

378853
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689423
units: 371312
value: 1.26E-19
type: LocalParameter

380839
stoichiometry: 1.0
species: 739599
type: SpeciesReference

739419
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741899
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

388571
local parameters: 690179
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

741959
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

386941
stoichiometry: 1.0
species: 741958
type: SpeciesReference

749338
kinetic law: 385599
product: 385587
reactant: 385575
reactant: 385563
fast: false
reversible: true
type: Reaction

375388
stoichiometry: 1.0
species: 737999
type: SpeciesReference

742198
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359
type: Species

381117
stoichiometry: 1.0
species: 739239
type: SpeciesReference

387640
stoichiometry: 1.0
species: 742058
type: SpeciesReference

746078
kinetic law: 377703
product: 377691
product: 377678
reactant: 377666
fast: false
reversible: false
type: Reaction

689742
units: 371397
value: 3.0779838E-18
type: LocalParameter

689956
units: 371312
value: 6.8E-18
type: LocalParameter

746678
kinetic law: 379156
product: 379143
product: 379131
reactant: 379119
fast: false
reversible: false
type: Reaction

690051
units: 371312
value: 1.4E-17
type: LocalParameter

388051
stoichiometry: 1.0
species: 742138
type: SpeciesReference

689422
units: 371312
value: 3.5E-21
type: LocalParameter

385575
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689812
units: 371312
value: 5.4E-16
type: LocalParameter

382533
stoichiometry: 1.0
species: 739239
type: SpeciesReference

378176
stoichiometry: 1.0
species: 738199
type: SpeciesReference

690091
units: 371312
value: 2.106E-16
type: LocalParameter

689895
units: 371397
value: 3.999888E-17
type: LocalParameter

746878
kinetic law: 379639
product: 379627
product: 379614
reactant: 379602
fast: false
reversible: false
type: Reaction

746038
kinetic law: 377606
product: 377594
product: 377582
reactant: 377569
fast: false
reversible: false
type: Reaction

746638
kinetic law: 379059
product: 379047
product: 379035
reactant: 379023
fast: false
reversible: false
type: Reaction

742158
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 737359
type: Species

384573
stoichiometry: 1.0
species: 740379
type: SpeciesReference

384212
stoichiometry: 1.0
species: 741819
type: SpeciesReference

382291
stoichiometry: 1.0
species: 739899
type: SpeciesReference

740299
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 737359
type: Species

689854
units: 371397
value: 3.999888E-17
type: LocalParameter

385419
stoichiometry: 1.0
species: 740879
type: SpeciesReference

377436
stoichiometry: 1.0
species: 738199
type: SpeciesReference

739459
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

743798
kinetic law: 372301
product: 372289
reactant: 372277
reactant: 372265
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true
type: Reaction

689955
units: 371397
value: 8.7498E-18
type: LocalParameter

748678
kinetic law: 384007
product: 383994
product: 383982
reactant: 383970
fast: false
reversible: false
type: Reaction

374600
local parameters: 689522
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

690052
units: 371312
value: 3.5E-18
type: LocalParameter

378732
stoichiometry: 1.0
species: 738939
type: SpeciesReference

386048
stoichiometry: 1.0
species: 741599
type: SpeciesReference

377242
stoichiometry: 1.0
species: 738199
type: SpeciesReference

737419
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 737339
type: Species

737939
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

373944
stoichiometry: 1.0
species: 742398
type: SpeciesReference

377728
stoichiometry: 1.0
species: 738199
type: SpeciesReference

740819
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

384357
stoichiometry: 1.0
species: 740659
type: SpeciesReference

689796
units: 371397
value: 3.5998992E-16
type: LocalParameter

689638
units: 371397
value: 1.8106416E-16
type: LocalParameter

387520
stoichiometry: 1.0
species: 741979
type: SpeciesReference

385203
stoichiometry: 1.0
species: 740839
type: SpeciesReference

371747
stoichiometry: 1.0
species: 737859
type: SpeciesReference

746938
kinetic law: 379787
product: 379775
reactant: 379763
reactant: 379751
fast: false
reversible: true
type: Reaction

689398
units: 371312
value: 9.0E-18
type: LocalParameter

378890
stoichiometry: 1.0
species: 738199
type: SpeciesReference

740699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

378212
stoichiometry: 1.0
species: 738199
type: SpeciesReference

741599
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

371674
stoichiometry: 1.0
species: 737779
type: SpeciesReference

387074
local parameters: 690118
local parameters: 690116
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr305_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

689581
units: 371312
value: 1.8E-16
type: LocalParameter

373109
local parameters: 689432
local parameters: 689431
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*Anchor
type: KineticLaw

375012
stoichiometry: 1.0
species: 738059
type: SpeciesReference

384285
stoichiometry: 1.0
species: 740379
type: SpeciesReference

387748
local parameters: 690146
local parameters: 690144
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

387037
stoichiometry: 1.0
species: 741939
type: SpeciesReference

385094
stoichiometry: 1.0
species: 740379
type: SpeciesReference

738599
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689917
units: 371312
value: 9.0E-16
type: LocalParameter

382074
stoichiometry: 1.0
species: 741579
type: SpeciesReference

737979
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 737339
type: Species

377316
local parameters: 689664
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

745678
kinetic law: 376735
product: 376723
product: 376711
reactant: 376699
fast: false
reversible: false
type: Reaction

386553
stoichiometry: 1.0
species: 741039
type: SpeciesReference

739279
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

742938
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

375953
local parameters: 689601
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

741559
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

382471
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689811
units: 371312
value: 2.16E-15
type: LocalParameter

739339
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

690090
units: 371397
value: 1.020006E-18
type: LocalParameter

373266
local parameters: 689444
local parameters: 689443
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

689958
units: 371312
value: 1.7E-18
type: LocalParameter

689471
units: 371312
value: 9.0E-17
type: LocalParameter

373835
stoichiometry: 1.0
species: 741939
type: SpeciesReference

739719
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

747438
kinetic law: 380996
product: 380984
product: 380972
reactant: 380960
fast: false
reversible: false
type: Reaction

383644
stoichiometry: 1.0
species: 740379
type: SpeciesReference

385672
stoichiometry: 1.0
species: 740379
type: SpeciesReference

376663
stoichiometry: 1.0
species: 738199
type: SpeciesReference

371807
stoichiometry: 1.0
species: 740279
type: SpeciesReference

689396
units: 371312
value: 9.0E-17
type: LocalParameter

737459
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689997
units: 371312
value: 6.8E-18
type: LocalParameter

689959
units: 371397
value: 8.7498E-18
type: LocalParameter

378381
local parameters: 689713
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

750038
kinetic law: 387315
product: 387303
product: 387291
reactant: 387278
fast: false
reversible: false
type: Reaction

384116
stoichiometry: 1.0
species: 741559
type: SpeciesReference

741519
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 737359
type: Species

371361
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

375352
stoichiometry: 1.0
species: 737839
type: SpeciesReference

689470
units: 371312
value: 9.0E-17
type: LocalParameter

372554
stoichiometry: 1.0
species: 737399
type: SpeciesReference

737499
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689797
units: 371312
value: 2.16E-15
type: LocalParameter

747778
kinetic law: 381817
product: 381805
reactant: 381793
reactant: 381781
fast: false
reversible: true
type: Reaction

689919
units: 371397
value: 4.5359838E-16
type: LocalParameter

379823
stoichiometry: 1.0
species: 739239
type: SpeciesReference

689395
units: 371397
value: 4.4999712E-15
type: LocalParameter

741059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 737339
type: Species

689431
units: 371312
value: 8.0E-21
type: LocalParameter

689998
units: 371312
value: 1.7E-18
type: LocalParameter

383001
stoichiometry: 1.0
species: 740179
type: SpeciesReference

388014
stoichiometry: 1.0
species: 742978
type: SpeciesReference

387182
stoichiometry: 1.0
species: 741999
type: SpeciesReference

737779
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 737339
type: Species

738199
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

376506
stoichiometry: 1.0
species: 738459
type: SpeciesReference

381056
stoichiometry: 1.0
species: 739639
type: SpeciesReference

381965
local parameters: 689880
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

381696
stoichiometry: 1.0
species: 739239
type: SpeciesReference

383365
stoichiometry: 1.0
species: 740459
type: SpeciesReference

739679
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

742218
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 737359
type: Species

689521
units: 371312
value: 2.16E-15
type: LocalParameter

385732
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689634
units: 371397
value: 1.8106416E-16
type: LocalParameter

749598
kinetic law: 386228
product: 386216
product: 386204
reactant: 386192
fast: false
reversible: false
type: Reaction

389033
stoichiometry: 1.0
species: 741779
type: SpeciesReference

748458
kinetic law: 383475
product: 383463
reactant: 383450
reactant: 383437
fast: false
reversible: true
type: Reaction

380330
stoichiometry: 1.0
species: 741499
type: SpeciesReference

383160
stoichiometry: 1.0
species: 740379
type: SpeciesReference

385359
local parameters: 690039
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

381854
stoichiometry: 1.0
species: 739239
type: SpeciesReference

379011
local parameters: 689743
local parameters: 689742
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

744118
kinetic law: 373061
product: 373049
product: 373036
reactant: 373024
fast: false
reversible: true
type: Reaction

384646
stoichiometry: 1.0
species: 740719
type: SpeciesReference

376615
stoichiometry: 1.0
species: 741279
type: SpeciesReference

375169
stoichiometry: 1.0
species: 738059
type: SpeciesReference

379639
local parameters: 689772
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

746418
kinetic law: 378526
product: 378514
reactant: 378502
reactant: 378490
fast: false
reversible: true
type: Reaction

374710
stoichiometry: 1.0
species: 737659
type: SpeciesReference

382206
local parameters: 689892
local parameters: 689890
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

743698
kinetic law: 372060
product: 372047
product: 372035
reactant: 372023
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

388619
local parameters: 690182
local parameters: 690180
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

689799
units: 371312
value: 5.4E-16
type: LocalParameter

388280
local parameters: 690167
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

689522
units: 371312
value: 5.4E-16
type: LocalParameter

746298
kinetic law: 378236
product: 378224
reactant: 378212
reactant: 378200
fast: false
reversible: true
type: Reaction

375424
local parameters: 689561
local parameters: 689560
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

373374
stoichiometry: 1.0
species: 741519
type: SpeciesReference

689635
units: 371312
value: 7.2E-16
type: LocalParameter

372023
stoichiometry: 1.0
species: 738039
type: SpeciesReference

744158
kinetic law: 373157
product: 373145
product: 373133
reactant: 373121
fast: false
reversible: true
type: Reaction

374416
stoichiometry: 1.0
species: 737759
type: SpeciesReference

745518
kinetic law: 376344
product: 376331
product: 376318
reactant: 376305
fast: false
reversible: false
type: Reaction

386989
stoichiometry: 1.0
species: 741919
type: SpeciesReference

388412
stoichiometry: 1.0
species: 742218
type: SpeciesReference

386445
stoichiometry: 1.0
species: 737899
type: SpeciesReference

387688
stoichiometry: 1.0
species: 742938
type: SpeciesReference

386880
local parameters: 690109
local parameters: 690108
notes: k1*CaMKII_PSD_slash_CaMKII_star__star__star__minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

737559
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737339
type: Species

388316
stoichiometry: 1.0
species: 742198
type: SpeciesReference

374926
stoichiometry: 1.0
species: 738079
type: SpeciesReference

388948
stoichiometry: 1.0
species: 742978
type: SpeciesReference

376002
local parameters: 689604
local parameters: 689602
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

381322
stoichiometry: 1.0
species: 739699
type: SpeciesReference

690049
units: 371397
value: 8.7498E-18
type: LocalParameter

749558
kinetic law: 386132
product: 386120
product: 386108
reactant: 386096
fast: false
reversible: false
type: Reaction

689393
units: 371312
value: 9.0E-17
type: LocalParameter

377582
stoichiometry: 1.0
species: 741539
type: SpeciesReference

386590
stoichiometry: 1.0
species: 741139
type: SpeciesReference

744998
kinetic law: 375084
product: 375072
product: 375060
reactant: 375048
fast: false
reversible: false
type: Reaction

382963
stoichiometry: 1.0
species: 740159
type: SpeciesReference

371325
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

382687
stoichiometry: 1.0
species: 740059
type: SpeciesReference

376371
stoichiometry: 1.0
species: 738199
type: SpeciesReference

385069
local parameters: 690025
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

382315
stoichiometry: 1.0
species: 739899
type: SpeciesReference

377618
stoichiometry: 1.0
species: 741619
type: SpeciesReference

384912
stoichiometry: 1.0
species: 740779
type: SpeciesReference

745858
kinetic law: 377170
product: 377158
reactant: 377146
reactant: 377134
fast: false
reversible: true
type: Reaction

690048
units: 371312
value: 3.5E-18
type: LocalParameter

371951
stoichiometry: 1.0
species: 737899
type: SpeciesReference

377654
local parameters: 689680
local parameters: 689679
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

374343
stoichiometry: 1.0
species: 737499
type: SpeciesReference

689392
units: 371397
value: 5.399946E-15
type: LocalParameter

689524
units: 371397
value: 9.91197E-19
type: LocalParameter

689637
units: 371312
value: 1.8E-16
type: LocalParameter

689390
units: 371397
value: 1.6199838E-15
type: LocalParameter

385299
stoichiometry: 1.0
species: 740859
type: SpeciesReference

746778
kinetic law: 379397
product: 379385
reactant: 379373
reactant: 379361
fast: false
reversible: true
type: Reaction

749518
kinetic law: 386036
product: 386024
product: 386011
reactant: 385999
fast: false
reversible: false
type: Reaction

385636
stoichiometry: 1.0
species: 740379
type: SpeciesReference

372457
stoichiometry: 1.0
species: 739159
type: SpeciesReference

381395
stoichiometry: 1.0
species: 741739
type: SpeciesReference

379860
stoichiometry: 1.0
species: 739239
type: SpeciesReference

380718
stoichiometry: 1.0
species: 741259
type: SpeciesReference

746498
kinetic law: 378720
product: 378708
reactant: 378696
reactant: 378684
fast: false
reversible: true
type: Reaction

386325
stoichiometry: 1.0
species: 741039
type: SpeciesReference

382891
local parameters: 689925
local parameters: 689923
notes: k1*cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

744198
kinetic law: 373229
product: 373217
reactant: 373205
fast: false
reversible: true
type: Reaction

383608
stoichiometry: 1.0
species: 740379
type: SpeciesReference

689910
units: 371276
value: 299.9976000192
type: LocalParameter

741379
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

741779
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

377036
stoichiometry: 1.0
species: 741319
type: SpeciesReference

374016
local parameters: 689495
local parameters: 689494
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_PSD_slash_NMDAR-kb*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

689991
units: 371397
value: 8.7498E-18
type: LocalParameter

377872
stoichiometry: 1.0
species: 741639
type: SpeciesReference

384537
local parameters: 690001
local parameters: 690000
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

740759
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374161
local parameters: 689503
local parameters: 689501
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

745398
kinetic law: 376051
product: 376039
product: 376027
reactant: 376015
fast: false
reversible: false
type: Reaction

749258
kinetic law: 385407
product: 385395
reactant: 385383
reactant: 385371
fast: false
reversible: true
type: Reaction

689477
units: 371397
value: 0.0
type: LocalParameter

690155
units: 371312
value: 5.0E-18
type: LocalParameter

387303
stoichiometry: 1.0
species: 742918
type: SpeciesReference

689525
units: 371312
value: 1.8E-16
type: LocalParameter

748138
kinetic law: 382699
product: 382687
reactant: 382675
reactant: 382663
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true
type: Reaction

744598
kinetic law: 374112
product: 374100
product: 374088
reactant: 374076
fast: false
reversible: false
type: Reaction

745258
kinetic law: 375713
product: 375700
reactant: 375688
reactant: 375676
fast: false
reversible: true
type: Reaction

749878
kinetic law: 386929
product: 386916
product: 386904
reactant: 386892
fast: false
reversible: false
type: Reaction

747698
kinetic law: 381624
product: 381612
reactant: 381600
reactant: 381587
fast: false
reversible: true
type: Reaction

690154
units: 371312
value: 2.0E-17
type: LocalParameter

376111
stoichiometry: 1.0
species: 738379
type: SpeciesReference

744558
kinetic law: 374016
product: 374004
reactant: 373992
reactant: 373980
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

689992
units: 371312
value: 6.8E-18
type: LocalParameter

388207
stoichiometry: 1.0
species: 742978
type: SpeciesReference

381479
local parameters: 689857
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

382423
stoichiometry: 1.0
species: 741779
type: SpeciesReference

386373
stoichiometry: 1.0
species: 741099
type: SpeciesReference

740479
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

740719
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

386771
stoichiometry: 1.0
species: 741899
type: SpeciesReference

388521
local parameters: 690178
local parameters: 690176
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

379590
local parameters: 689770
local parameters: 689769
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

372808
stoichiometry: 1.0
species: 740299
type: SpeciesReference

373049
stoichiometry: 1.0
species: 741519
type: SpeciesReference

386626
stoichiometry: 1.0
species: 741039
type: SpeciesReference

743538
kinetic law: 371699
product: 371686
reactant: 371674
reactant: 371662
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

689631
units: 371312
value: 7.2E-16
type: LocalParameter

689476
units: 371312
value: 5.0E-17
type: LocalParameter

386904
stoichiometry: 1.0
species: 741978
type: SpeciesReference

747298
kinetic law: 380658
product: 380646
reactant: 380634
reactant: 380622
fast: false
reversible: true
type: Reaction

747838
kinetic law: 381965
product: 381952
product: 381940
reactant: 381927
fast: false
reversible: false
type: Reaction

372132
stoichiometry: 2.0
species: 737559
type: SpeciesReference

744658
kinetic law: 374259
product: 374247
reactant: 374235
reactant: 374223
fast: false
reversible: true
type: Reaction

689790
units: 371312
value: 5.4E-16
type: LocalParameter

383329
local parameters: 689944
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

372240
stoichiometry: 1.0
species: 739079
type: SpeciesReference

379787
local parameters: 689779
local parameters: 689778
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

373193
local parameters: 689438
local parameters: 689437
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

747618
kinetic law: 381431
product: 381419
reactant: 381407
reactant: 381395
fast: false
reversible: true
type: Reaction

745358
kinetic law: 375953
product: 375941
product: 375929
reactant: 375917
fast: false
reversible: false
type: Reaction

375881
stoichiometry: 1.0
species: 738199
type: SpeciesReference

385780
stoichiometry: 1.0
species: 740959
type: SpeciesReference

747218
kinetic law: 380463
product: 380451
reactant: 380439
reactant: 380427
fast: false
reversible: true
type: Reaction

372349
local parameters: 689381
local parameters: 689380
notes: kf*PKA_slash_R2C2_minus_cAMP2*cAMP-kb*PKA_slash_R2C2_minus_cAMP3
type: KineticLaw

747398
kinetic law: 380900
product: 380888
product: 380875
reactant: 380863
fast: false
reversible: false
type: Reaction

381503
stoichiometry: 1.0
species: 739239
type: SpeciesReference

749938
kinetic law: 387074
product: 387062
reactant: 387050
reactant: 387037
fast: false
reversible: true
type: Reaction

747998
kinetic law: 382351
product: 382339
product: 382327
reactant: 382315
fast: false
reversible: false
type: Reaction

689527
units: 371312
value: 4.5E-17
type: LocalParameter

380767
stoichiometry: 1.0
species: 739579
type: SpeciesReference

689632
units: 371312
value: 1.8E-16
type: LocalParameter

689479
units: 371397
value: 4.99998E-16
type: LocalParameter

749978
kinetic law: 387170
product: 387158
reactant: 387146
reactant: 387134
fast: false
reversible: true
type: Reaction

690152
units: 371397
value: 2.77776E-19
type: LocalParameter

689911
units: 371312
value: 1.8E-16
type: LocalParameter

740439
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

689528
units: 371397
value: 7.714278E-18
type: LocalParameter

388244
stoichiometry: 1.0
species: 742178
type: SpeciesReference

747358
kinetic law: 380803
product: 380791
product: 380779
reactant: 380767
fast: false
reversible: false
type: Reaction

750478
kinetic law: 388376
product: 388364
product: 388352
reactant: 388340
fast: false
reversible: false
type: Reaction

376723
stoichiometry: 1.0
species: 738199
type: SpeciesReference

747958
kinetic law: 382254
product: 382242
product: 382230
reactant: 382218
fast: false
reversible: false
type: Reaction

380488
stoichiometry: 1.0
species: 741339
type: SpeciesReference

383693
stoichiometry: 1.0
species: 741559
type: SpeciesReference

377933
stoichiometry: 1.0
species: 738779
type: SpeciesReference

385527
stoichiometry: 1.0
species: 741759
type: SpeciesReference

745318
kinetic law: 375857
product: 375845
product: 375833
reactant: 375821
fast: false
reversible: false
type: Reaction

371433
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

384465
stoichiometry: 1.0
species: 741579
type: SpeciesReference

689701
units: 371397
value: 2.011824E-17
type: LocalParameter

378321
stoichiometry: 1.0
species: 738859
type: SpeciesReference

373593
stoichiometry: 1.0
species: 740279
type: SpeciesReference

739119
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

378974
stoichiometry: 1.0
species: 737999
type: SpeciesReference

382572
stoichiometry: 1.0
species: 737539
type: SpeciesReference

740319
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

374124
stoichiometry: 1.0
species: 737659
type: SpeciesReference

388461
stoichiometry: 1.0
species: 742978
type: SpeciesReference

690151
units: 371312
value: 5.0E-18
type: LocalParameter

689995
units: 371397
value: 8.7498E-18
type: LocalParameter

750778
kinetic law: 389109
product: 389096
reactant: 389083
reactant: 389070
fast: false
reversible: true
type: Reaction

689348
units: 371312
value: 1.0E-16
type: LocalParameter

385179
stoichiometry: 1.0
species: 741699
type: SpeciesReference

689914
units: 371397
value: 2.2680162E-16
type: LocalParameter

373085
stoichiometry: 1.0
species: 741219
type: SpeciesReference

386264
stoichiometry: 1.0
species: 741079
type: SpeciesReference

372662
local parameters: 689402
local parameters: 689401
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE
type: KineticLaw

738879
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689473
units: 371312
value: 1.0E-17
type: LocalParameter

375120
stoichiometry: 1.0
species: 738119
type: SpeciesReference

384393
local parameters: 689994
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

379059
local parameters: 689745
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

376087
stoichiometry: 1.0
species: 738379
type: SpeciesReference

375604
stoichiometry: 1.0
species: 738279
type: SpeciesReference

378624
local parameters: 689725
local parameters: 689724
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

372976
stoichiometry: 1.0
species: 741599
type: SpeciesReference

750738
kinetic law: 389008
product: 388996
reactant: 388984
reactant: 388972
fast: false
reversible: true
type: Reaction

743478
kinetic law: 371554
product: 371542
reactant: 371530
reactant: 371517
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

690150
units: 371312
value: 2.0E-17
type: LocalParameter

689791
units: 371397
value: 3.5998992E-16
type: LocalParameter

738839
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

689347
units: 371397
value: 3.6E-17
type: LocalParameter

740059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339
type: Species

377981
stoichiometry: 1.0
species: 738199
type: SpeciesReference

689686
units: 371312
value: 1.8E-16
type: LocalParameter

689913
units: 371276
value: 300.001920012288
type: LocalParameter

385311
local parameters: 690037
local parameters: 690036
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

373447
local parameters: 689456
local parameters: 689455
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_
type: KineticLaw

374758
stoichiometry: 1.0
species: 737719
type: SpeciesReference

387146
stoichiometry: 1.0
species: 742918
type: SpeciesReference

378490
stoichiometry: 1.0
species: 741839
type: SpeciesReference

389257
local parameters: 690208
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

741819
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

384429
stoichiometry: 1.0
species: 740679
type: SpeciesReference

376772
stoichiometry: 1.0
species: 738519
type: SpeciesReference

382363
stoichiometry: 1.0
species: 741599
type: SpeciesReference

376195
local parameters: 689613
local parameters: 689611
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

689794
units: 371312
value: 5.4E-16
type: LocalParameter

383584
stoichiometry: 1.0
species: 740499
type: SpeciesReference

380053
stoichiometry: 1.0
species: 739239
type: SpeciesReference

388837
stoichiometry: 1.0
species: 741599
type: SpeciesReference

373726
local parameters: 689477
local parameters: 689476
notes: kf*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_PSD_slash_CaMKII_minus_PSD
type: KineticLaw

380126
local parameters: 689794
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

377206
stoichiometry: 1.0
species: 738199
type: SpeciesReference

748898
kinetic law: 384537
product: 384525
reactant: 384513
reactant: 384501
fast: false
reversible: true
type: Reaction

689916
units: 371312
value: 3.6E-15
type: LocalParameter

377073
local parameters: 689653
local parameters: 689652
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

385563
stoichiometry: 1.0
species: 741659
type: SpeciesReference

379933
local parameters: 689785
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

689689
units: 371312
value: 7.2E-16
type: LocalParameter

744318
kinetic law: 373495
product: 373483
reactant: 373471
reactant: 373459
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true
type: Reaction

741859
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359
type: Species

375096
stoichiometry: 1.0
species: 740319
type: SpeciesReference

740359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

376808
stoichiometry: 1.0
species: 741379
type: SpeciesReference

MODEL9087474843
reaction: 743678
species: 742918
reaction: 748278
species: 742038
reaction: 745378
reaction: 743978
reaction: 747738
reaction: 744858
reaction: 749418
species: 739079
species: 738059
reaction: 745678
reaction: 747878
species: 739999
species: 740779
reaction: 744498
species: 739259
reaction: 744458
species: 738879
species: 741619
reaction: 745238
species: 741559
species: 742118
species: 737679
species: 738139
reaction: 745038
species: 740419
species: 738559
reaction: 746598
species: 741978
reaction: 750618
reaction: 750698
species: 742758
species: 737859
species: 742818
reaction: 743858
species: 738819
reaction: 743898
reaction: 748758
reaction: 750418
units def: 371276
species: 741799
species: 740859
reaction: 746078
reaction: 750758
species: 742058
notes: This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 746538
reaction: 748818
reaction: 746838
reaction: 748898
species: 740179
species: 738079
species: 739599
reaction: 750058
reaction: 749198
reaction: 746258
rule: 743318
species: 742998
reaction: 750398
rule: 743058
species: 739279
reaction: 746018
rule: 743098
reaction: 750118
reaction: 750198
species: 741639
species: 737759
species: 740119
species: 740439
reaction: 749138
species: 742138
reaction: 747378
reaction: 749738
reaction: 747098
species: 742838
species: 739919
reaction: 747558
reaction: 743878
reaction: 749878

749238
kinetic law: 385359
product: 385347
product: 385335
reactant: 385323
fast: false
reversible: false
type: Reaction

380658
local parameters: 689820
local parameters: 689818
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

383838
stoichiometry: 1.0
species: 740379
type: SpeciesReference

748858
kinetic law: 384441
product: 384429
reactant: 384417
reactant: 384405
fast: false
reversible: true
type: Reaction

388087
local parameters: 690159
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

689700
units: 371312
value: 1.8E-16
type: LocalParameter

388123
stoichiometry: 1.0
species: 742158
type: SpeciesReference

689399
units: 371312
value: 0.0
type: LocalParameter

689994
units: 371312
value: 1.7E-18
type: LocalParameter

374866
stoichiometry: 1.0
species: 737619
type: SpeciesReference

689540
units: 371312
value: 1.8E-16
type: LocalParameter

689793
units: 371312
value: 2.16E-15
type: LocalParameter

381915
local parameters: 689878
local parameters: 689877
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

689688
units: 371397
value: 2.011824E-17
type: LocalParameter

385842
local parameters: 690061
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

740399
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359
type: Species

385021
local parameters: 690024
local parameters: 690022
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

380198
stoichiometry: 1.0
species: 741399
type: SpeciesReference

742418
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339
type: Species

388886
stoichiometry: 1.0
species: 742978
type: SpeciesReference

689474
units: 371312
value: 1.0E-17
type: LocalParameter

377352
stoichiometry: 1.0
species: 738639
type: SpeciesReference

375243
stoichiometry: 1.0
species: 738139
type: SpeciesReference

384007
local parameters: 689976
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw