958606
units: 331247
value: 2.16E-15
type: LocalParameter

726660
kinetic law: 331874
product: 331862
reactant: 331850
reactant: 331838
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

958542
units: 331247
value: 1.0E-17
type: LocalParameter

724100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

724120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

332817
stoichiometry: 1.0
species: 725460
type: SpeciesReference

336341
local parameters: 958721
local parameters: 958719
notes: k1*CaMKII_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

958656
units: 331247
value: 2.4E-16
type: LocalParameter

332343
local parameters: 958530
local parameters: 958529
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_minus_active_PSD
type: KineticLaw

335796
stoichiometry: 1.0
species: 725280
type: SpeciesReference

958607
units: 331247
value: 5.4E-16
type: LocalParameter

727580
kinetic law: 334009
product: 333997
reactant: 333985
reactant: 333973
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

336569
stoichiometry: 1.0
species: 725580
type: SpeciesReference

958696
units: 331247
value: 1.224E-16
type: LocalParameter

958543
units: 331247
value: 1.0E-17
type: LocalParameter

958746
units: 331247
value: 9.0E-16
type: LocalParameter

332259
local parameters: 958526
local parameters: 958525
notes: kf*CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

336740
stoichiometry: 1.0
species: 725680
type: SpeciesReference

332877
stoichiometry: 1.0
species: 725780
type: SpeciesReference

336001
local parameters: 958702
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

332755
local parameters: 958551
local parameters: 958550
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE
type: KineticLaw

334702
stoichiometry: 1.0
species: 724700
type: SpeciesReference

332961
stoichiometry: 1.0
species: 725460
type: SpeciesReference

727380
kinetic law: 333526
product: 333514
reactant: 333502
reactant: 333490
fast: false
reversible: true
type: Reaction

958731
units: 331247
value: 9.0E-16
type: LocalParameter

725300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958544
units: 331247
value: 2.25E-16
type: LocalParameter

332162
local parameters: 958522
local parameters: 958520
notes: kf*CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*NMDAR
type: KineticLaw

334518
stoichiometry: 1.0
species: 724600
type: SpeciesReference

332018
local parameters: 958515
local parameters: 958514
notes: kf*CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

958604
units: 331331
value: 1.1894364E-17
type: LocalParameter

334240
stoichiometry: 1.0
species: 726140
type: SpeciesReference

725340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958745
units: 331247
value: 3.6E-15
type: LocalParameter

333057
stoichiometry: 1.0
species: 724180
type: SpeciesReference

334154
local parameters: 958612
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

726780
kinetic law: 332162
product: 332150
product: 332138
reactant: 332126
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true
type: Reaction

958697
units: 331247
value: 3.06E-17
type: LocalParameter

727500
kinetic law: 333816
product: 333804
reactant: 333792
reactant: 333780
fast: false
reversible: true
type: Reaction

335880
stoichiometry: 1.0
species: 724600
type: SpeciesReference

726760
kinetic law: 332114
product: 332102
reactant: 332090
reactant: 332078
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

334045
stoichiometry: 1.0
species: 726120
type: SpeciesReference

333240
stoichiometry: 1.0
species: 724060
type: SpeciesReference

336655
stoichiometry: 1.0
species: 725560
type: SpeciesReference

331934
stoichiometry: 1.0
species: 724020
type: SpeciesReference

333349
stoichiometry: 1.0
species: 724260
type: SpeciesReference

958545
units: 331247
value: 2.25E-16
type: LocalParameter

335820
stoichiometry: 1.0
species: 724580
type: SpeciesReference

958730
units: 331247
value: 3.6E-15
type: LocalParameter

331778
local parameters: 958505
local parameters: 958504
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

725380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723980
type: Species

958657
units: 331247
value: 6.0E-17
type: LocalParameter

727540
kinetic law: 333913
product: 333901
reactant: 333889
reactant: 333877
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true
type: Reaction

333708
stoichiometry: 1.0
species: 724200
type: SpeciesReference

725920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333804
stoichiometry: 1.0
species: 724220
type: SpeciesReference

333985
stoichiometry: 1.0
species: 726120
type: SpeciesReference

335490
stoichiometry: 1.0
species: 724860
type: SpeciesReference

333313
stoichiometry: 1.0
species: 724080
type: SpeciesReference

335211
stoichiometry: 1.0
species: 726160
type: SpeciesReference

726140
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723960
type: Species

331826
local parameters: 958507
local parameters: 958506
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1
type: KineticLaw

958691
units: 331247
value: 1.224E-16
type: LocalParameter

726160
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723980
type: Species

958632
units: 331247
value: 1.8E-16
type: LocalParameter

336545
stoichiometry: 1.0
species: 725600
type: SpeciesReference

331222
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

958546
units: 331331
value: 4.4999712E-15
type: LocalParameter

336497
stoichiometry: 1.0
species: 725460
type: SpeciesReference

335091
stoichiometry: 1.0
species: 724940
type: SpeciesReference

728680
kinetic law: 336680
product: 336668
product: 336655
reactant: 336642
fast: false
reversible: false
type: Reaction

958602
units: 331247
value: 8.1E-16
type: LocalParameter

725980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

958652
units: 331247
value: 3.06E-18
type: LocalParameter

334981
local parameters: 958656
local parameters: 958654
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

333156
stoichiometry: 1.0
species: 725900
type: SpeciesReference

958566
units: 331331
value: 1.6199838E-15
type: LocalParameter

726620
kinetic law: 331778
product: 331766
reactant: 331754
reactant: 331742
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

331428
stoichiometry: 1.0
species: 724280
type: SpeciesReference

725580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 723960
type: Species

334895
stoichiometry: 1.0
species: 724760
type: SpeciesReference

958671
units: 331247
value: 8.0E-18
type: LocalParameter

336920
local parameters: 958750
local parameters: 958748
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

336630
local parameters: 958735
local parameters: 958733
notes: k1*cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

958692
units: 331247
value: 3.06E-17
type: LocalParameter

332853
stoichiometry: 1.0
species: 725760
type: SpeciesReference

958631
units: 331247
value: 7.50006E-16
type: LocalParameter

725540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 723960
type: Species

728300
kinetic law: 335758
product: 335746
reactant: 335734
reactant: 335722
fast: false
reversible: true
type: Reaction

331295
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

958601
units: 331247
value: 3.24E-15
type: LocalParameter

958547
units: 331247
value: 9.0E-17
type: LocalParameter

725940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 723960
type: Species

728700
kinetic law: 336728
product: 336716
reactant: 336704
reactant: 336692
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true
type: Reaction

958651
units: 331247
value: 1.224E-17
type: LocalParameter

334578
stoichiometry: 1.0
species: 724680
type: SpeciesReference

958567
units: 331247
value: 5.4E-15
type: LocalParameter

726960
kinetic law: 332563
product: 332551
reactant: 332539
fast: false
reversible: true
type: Reaction

958591
units: 331247
value: 3.24E-15
type: LocalParameter

725000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00254583333333333
initial amount: NaN
in compartment: 723980
type: Species

958672
units: 331247
value: 2.0E-18
type: LocalParameter

332235
stoichiometry: 1.0
species: 725020
type: SpeciesReference

331910
stoichiometry: 1.0
species: 724800
type: SpeciesReference

334021
stoichiometry: 1.0
species: 724360
type: SpeciesReference

958634
units: 331331
value: 6.4584E-18
type: LocalParameter

336692
stoichiometry: 1.0
species: 725460
type: SpeciesReference

725080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

335151
stoichiometry: 1.0
species: 726160
type: SpeciesReference

333672
local parameters: 958587
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

335236
stoichiometry: 1.0
species: 724820
type: SpeciesReference

958548
units: 331247
value: 9.0E-18
type: LocalParameter

333130
local parameters: 958568
local parameters: 958567
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2_minus_cAMP4
type: KineticLaw

728020
kinetic law: 335079
product: 335067
reactant: 335055
reactant: 335043
fast: false
reversible: true
type: Reaction

958592
units: 331247
value: 8.1E-16
type: LocalParameter

725600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958568
units: 331331
value: 1.6199838E-15
type: LocalParameter

331621
stoichiometry: 1.0
species: 724980
type: SpeciesReference

336147
local parameters: 958711
local parameters: 958709
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

727420
kinetic law: 333624
product: 333612
reactant: 333600
reactant: 333587
fast: false
reversible: true
type: Reaction

334859
stoichiometry: 1.0
species: 724720
type: SpeciesReference

725060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 723980
type: Species

728000
kinetic law: 335030
product: 335018
product: 335005
reactant: 334993
fast: false
reversible: false
type: Reaction

334264
stoichiometry: 1.0
species: 724280
type: SpeciesReference

334665
stoichiometry: 1.0
species: 724620
type: SpeciesReference

958654
units: 331331
value: 6.0E-19
type: LocalParameter

333033
local parameters: 958564
local parameters: 958563
notes: kf*cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4
type: KineticLaw

723960
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

728060
kinetic law: 335175
product: 335163
reactant: 335151
reactant: 335139
fast: false
reversible: true
type: Reaction

728600
kinetic law: 336485
modifier: 336473
product: 336461
reactant: 336449
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false
type: Reaction

958748
units: 331331
value: 5.399946E-17
type: LocalParameter

727460
kinetic law: 333720
product: 333708
reactant: 333696
reactant: 333684
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

958694
units: 331331
value: 3.0779838E-17
type: LocalParameter

333961
local parameters: 958602
notes: k3*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

333877
stoichiometry: 1.0
species: 725580
type: SpeciesReference

724860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

333009
stoichiometry: 1.0
species: 725820
type: SpeciesReference

331970
local parameters: 958513
local parameters: 958512
notes: kf*CaM_minus_Ca4*CaNAB_minus_Ca4-kb*CaM_Ca_n_minus_CaNAB
type: KineticLaw

958549
units: 331247
value: 0.0
type: LocalParameter

335844
stoichiometry: 1.0
species: 725320
type: SpeciesReference

958569
units: 331331
value: 5.399946E-15
type: LocalParameter

724840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

335502
stoichiometry: 1.0
species: 725140
type: SpeciesReference

728040
kinetic law: 335127
product: 335115
product: 335103
reactant: 335091
fast: false
reversible: false
type: Reaction

334179
stoichiometry: 1.0
species: 726140
type: SpeciesReference

958674
units: 331331
value: 4.99998E-18
type: LocalParameter

958562
units: 331247
value: 9.9E-15
type: LocalParameter

336087
stoichiometry: 1.0
species: 725280
type: SpeciesReference

726680
kinetic law: 331922
product: 331910
reactant: 331898
reactant: 331886
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1.
fast: false
reversible: true
type: Reaction

726820
kinetic law: 332259
product: 332247
reactant: 332235
reactant: 332223
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

335612
local parameters: 958686
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

724540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 723960
type: Species

333265
stoichiometry: 1.0
species: 724040
type: SpeciesReference

726800
kinetic law: 332211
product: 332199
product: 332187
reactant: 332174
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

334907
stoichiometry: 1.0
species: 725060
type: SpeciesReference

724520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331271
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

958523
units: 331247
value: 3.0E-18
type: LocalParameter

332623
stoichiometry: 1.0
species: 725940
type: SpeciesReference

958563
units: 331331
value: 6.750054E-15
type: LocalParameter

336329
stoichiometry: 1.0
species: 725440
type: SpeciesReference

335527
stoichiometry: 1.0
species: 724900
type: SpeciesReference

335018
stoichiometry: 1.0
species: 726160
type: SpeciesReference

334871
stoichiometry: 1.0
species: 724760
type: SpeciesReference

958676
units: 331247
value: 8.0E-18
type: LocalParameter

335576
stoichiometry: 1.0
species: 725220
type: SpeciesReference

332563
local parameters: 958541
local parameters: 958540
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

336389
local parameters: 958722
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

331802
stoichiometry: 1.0
species: 724040
type: SpeciesReference

724500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

336521
stoichiometry: 1.0
species: 725600
type: SpeciesReference

958522
units: 331331
value: 5.4E-21
type: LocalParameter

332949
stoichiometry: 1.0
species: 725800
type: SpeciesReference

336872
local parameters: 958746
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

334215
stoichiometry: 1.0
species: 724400
type: SpeciesReference

958564
units: 331247
value: 2.925E-15
type: LocalParameter

331730
local parameters: 958503
local parameters: 958501
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD
type: KineticLaw

335055
stoichiometry: 1.0
species: 726160
type: SpeciesReference

958677
units: 331247
value: 2.0E-18
type: LocalParameter

332295
local parameters: 958528
local parameters: 958527
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4
type: KineticLaw

725360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335260
stoichiometry: 1.0
species: 725160
type: SpeciesReference

958525
units: 331331
value: 1.00002E-14
type: LocalParameter

333853
stoichiometry: 1.0
species: 724180
type: SpeciesReference

334288
stoichiometry: 1.0
species: 724420
type: SpeciesReference

334945
stoichiometry: 1.0
species: 724860
type: SpeciesReference

958565
units: 331247
value: 5.4E-15
type: LocalParameter

331645
stoichiometry: 1.0
species: 724980
type: SpeciesReference

335953
local parameters: 958701
local parameters: 958699
notes: k1*PP1_PSD_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

333780
stoichiometry: 1.0
species: 725060
type: SpeciesReference

335175
local parameters: 958666
local parameters: 958664
notes: k1*CaMKII_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

332211
local parameters: 958524
local parameters: 958523
notes: kf*CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*NMDAR
type: KineticLaw

958524
units: 331331
value: 5.4E-21
type: LocalParameter

727520
kinetic law: 333865
product: 333853
product: 333841
reactant: 333829
fast: false
reversible: false
type: Reaction

334554
stoichiometry: 1.0
species: 725080
type: SpeciesReference

333937
stoichiometry: 1.0
species: 725620
type: SpeciesReference

333696
stoichiometry: 1.0
species: 724180
type: SpeciesReference

334481
stoichiometry: 1.0
species: 724660
type: SpeciesReference

958679
units: 331331
value: 4.99998E-18
type: LocalParameter

332647
stoichiometry: 1.0
species: 724020
type: SpeciesReference

332985
local parameters: 958562
local parameters: 958561
notes: kf*PKA_slash_R2C2_minus_cAMP2*cAMP-kb*PKA_slash_R2C2_minus_cAMP3
type: KineticLaw

725560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958699
units: 331331
value: 3.420036E-18
type: LocalParameter

333289
stoichiometry: 1.0
species: 724340
type: SpeciesReference

336063
stoichiometry: 1.0
species: 725360
type: SpeciesReference

331694
stoichiometry: 1.0
species: 725000
type: SpeciesReference

331356
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

336365
stoichiometry: 1.0
species: 724860
type: SpeciesReference

726600
kinetic law: 331730
product: 331718
reactant: 331706
reactant: 331694
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

332368
stoichiometry: 1.0
species: 725140
type: SpeciesReference

725960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 723960
type: Species

335637
stoichiometry: 1.0
species: 725140
type: SpeciesReference

333477
local parameters: 958579
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

958609
units: 331331
value: 9.91197E-19
type: LocalParameter

336606
stoichiometry: 1.0
species: 725620
type: SpeciesReference

335103
stoichiometry: 1.0
species: 724820
type: SpeciesReference

958501
units: 331331
value: 4.65012E-18
type: LocalParameter

335771
stoichiometry: 1.0
species: 725300
type: SpeciesReference

335284
stoichiometry: 1.0
species: 725160
type: SpeciesReference

958560
units: 331247
value: 2.97E-15
type: LocalParameter

958540
units: 331247
value: 1.0E-15
type: LocalParameter

331609
stoichiometry: 2.0
species: 725040
type: SpeciesReference

332187
stoichiometry: 1.0
species: 724440
type: SpeciesReference

332271
stoichiometry: 1.0
species: 725020
type: SpeciesReference

725620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331754
stoichiometry: 1.0
species: 724040
type: SpeciesReference

727440
kinetic law: 333672
product: 333660
product: 333648
reactant: 333636
fast: false
reversible: false
type: Reaction

335199
stoichiometry: 1.0
species: 724860
type: SpeciesReference

728220
kinetic law: 335564
product: 335551
reactant: 335539
reactant: 335527
fast: false
reversible: true
type: Reaction

333913
local parameters: 958601
local parameters: 958599
notes: k1*AC_slash_cAMP_minus_PDE*PKA_minus_active-k2*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

958561
units: 331331
value: 6.750054E-15
type: LocalParameter

724440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958500
units: 331247
value: 1.0E-16
type: LocalParameter

332307
stoichiometry: 1.0
species: 725120
type: SpeciesReference

331958
stoichiometry: 1.0
species: 725280
type: SpeciesReference

334530
stoichiometry: 1.0
species: 724620
type: SpeciesReference

334969
stoichiometry: 1.0
species: 724920
type: SpeciesReference

958541
units: 331247
value: 1.0E-15
type: LocalParameter

335977
stoichiometry: 1.0
species: 725060
type: SpeciesReference

728240
kinetic law: 335612
product: 335600
product: 335588
reactant: 335576
fast: false
reversible: false
type: Reaction

334093
stoichiometry: 1.0
species: 724380
type: SpeciesReference

958520
units: 331247
value: 3.0E-18
type: LocalParameter

334130
stoichiometry: 1.0
species: 724300
type: SpeciesReference

333425
local parameters: 958578
local parameters: 958577
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

336255
stoichiometry: 1.0
species: 725420
type: SpeciesReference

335030
local parameters: 958657
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

958518
units: 331331
value: 1.08E-20
type: LocalParameter

333636
stoichiometry: 1.0
species: 724140
type: SpeciesReference

334433
stoichiometry: 1.0
species: 724620
type: SpeciesReference

958519
units: 331247
value: 0.0
type: LocalParameter

334615
stoichiometry: 1.0
species: 725060
type: SpeciesReference

335710
local parameters: 958689
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

958704
units: 331331
value: 3.420036E-18
type: LocalParameter

958706
units: 331247
value: 1.224E-16
type: LocalParameter

727220
kinetic law: 333130
product: 333118
product: 333106
reactant: 333094
fast: false
reversible: true
type: Reaction

332611
stoichiometry: 1.0
species: 726100
type: SpeciesReference

331465
stoichiometry: 1.0
species: 724020
type: SpeciesReference

336401
stoichiometry: 1.0
species: 726080
type: SpeciesReference

724600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335746
stoichiometry: 1.0
species: 725300
type: SpeciesReference

331525
stoichiometry: 1.0
species: 724520
type: SpeciesReference

333399
stoichiometry: 1.0
species: 724040
type: SpeciesReference

335551
stoichiometry: 1.0
species: 725220
type: SpeciesReference

727200
kinetic law: 333082
product: 333069
product: 333057
reactant: 333045
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true
type: Reaction

333538
stoichiometry: 1.0
species: 724120
type: SpeciesReference

333720
local parameters: 958591
local parameters: 958589
notes: k1*PP1_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

958707
units: 331247
value: 3.06E-17
type: LocalParameter

332417
stoichiometry: 1.0
species: 724160
type: SpeciesReference

727600
kinetic law: 334057
product: 334045
product: 334033
reactant: 334021
fast: false
reversible: false
type: Reaction

335393
stoichiometry: 1.0
species: 724880
type: SpeciesReference

335478
stoichiometry: 1.0
species: 725200
type: SpeciesReference

332901
stoichiometry: 1.0
species: 725780
type: SpeciesReference

334348
local parameters: 958622
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

336800
stoichiometry: 1.0
species: 725700
type: SpeciesReference

333192
stoichiometry: 1.0
species: 724300
type: SpeciesReference

335808
local parameters: 958692
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

333550
stoichiometry: 1.0
species: 724440
type: SpeciesReference

336716
stoichiometry: 1.0
species: 725680
type: SpeciesReference

332502
stoichiometry: 1.0
species: 726020
type: SpeciesReference

725780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331862
stoichiometry: 1.0
species: 724720
type: SpeciesReference

336316
stoichiometry: 1.0
species: 726280
type: SpeciesReference

332683
local parameters: 958547
local parameters: 958546
notes: kf*CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM
type: KineticLaw

725100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

958579
units: 331247
value: 2.25E-16
type: LocalParameter

727120
kinetic law: 332889
product: 332877
reactant: 332865
reactant: 332853
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true
type: Reaction

727700
kinetic law: 334300
product: 334288
reactant: 334276
reactant: 334264
fast: false
reversible: true
type: Reaction

958514
units: 331331
value: 4.99998E-16
type: LocalParameter

727740
kinetic law: 334396
product: 334384
reactant: 334372
reactant: 334360
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

958709
units: 331331
value: 9.375E-19
type: LocalParameter

726120
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331573
stoichiometry: 1.0
species: 724500
type: SpeciesReference

726100
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 723960
type: Species

958729
units: 331331
value: 2.2680162E-16
type: LocalParameter

726520
kinetic law: 331537
product: 331525
reactant: 331513
reactant: 331501
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

336908
stoichiometry: 1.0
species: 725960
type: SpeciesReference

333612
stoichiometry: 1.0
species: 724140
type: SpeciesReference

727140
kinetic law: 332937
product: 332925
reactant: 332913
reactant: 332901
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true
type: Reaction

724420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 723960
type: Species

728640
kinetic law: 336582
product: 336569
product: 336557
reactant: 336545
fast: false
reversible: false
type: Reaction

727760
kinetic law: 334445
product: 334433
product: 334420
reactant: 334408
fast: false
reversible: false
type: Reaction

336231
stoichiometry: 1.0
species: 725420
type: SpeciesReference

958578
units: 331247
value: 9.0E-16
type: LocalParameter

958515
units: 331247
value: 0.0
type: LocalParameter

728180
kinetic law: 335466
product: 335454
reactant: 335442
reactant: 335430
fast: false
reversible: true
type: Reaction

725120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

331549
stoichiometry: 1.0
species: 724520
type: SpeciesReference

725640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333514
stoichiometry: 1.0
species: 724120
type: SpeciesReference

727160
kinetic law: 332985
product: 332973
reactant: 332961
reactant: 332949
fast: false
reversible: true
type: Reaction

336896
stoichiometry: 1.0
species: 725940
type: SpeciesReference

727780
kinetic law: 334493
product: 334481
reactant: 334469
reactant: 334457
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

727180
kinetic law: 333033
product: 333021
reactant: 333009
reactant: 332997
fast: false
reversible: true
type: Reaction

725140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 723980
type: Species

331489
local parameters: 958492
local parameters: 958491
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

723947
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

335079
local parameters: 958661
local parameters: 958659
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

333106
stoichiometry: 1.0
species: 724180
type: SpeciesReference

958516
units: 331331
value: 1.08E-20
type: LocalParameter

725040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 723980
type: Species

335139
stoichiometry: 1.0
species: 724880
type: SpeciesReference

336219
stoichiometry: 1.0
species: 726280
type: SpeciesReference

726920
kinetic law: 332490
product: 332477
product: 332465
reactant: 332453
fast: false
reversible: true
type: Reaction

334324
stoichiometry: 1.0
species: 724300
type: SpeciesReference

332925
stoichiometry: 1.0
species: 725800
type: SpeciesReference

724360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 723960
type: Species

725020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

333575
local parameters: 958582
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

725440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

336594
stoichiometry: 1.0
species: 725460
type: SpeciesReference

958517
units: 331247
value: 0.0
type: LocalParameter

332066
local parameters: 958517
local parameters: 958516
notes: kf*CaMKII_slash_CaMKII_minus_CaM*NMDAR-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

724800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

332587
stoichiometry: 1.0
species: 725380
type: SpeciesReference

331886
stoichiometry: 1.0
species: 724780
type: SpeciesReference

332392
local parameters: 958532
local parameters: 958531
notes: kf*PP1_PSD_slash_I1_star_*PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

334652
stoichiometry: 1.0
species: 725100
type: SpeciesReference

336824
local parameters: 958745
local parameters: 958743
notes: k1*cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

724760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335321
local parameters: 958672
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

725160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

724820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

725180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

332526
local parameters: 958539
local parameters: 958537
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

331597
stoichiometry: 1.0
species: 724480
type: SpeciesReference

334300
local parameters: 958621
local parameters: 958619
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

728580
kinetic law: 336437
modifier: 336425
product: 336413
reactant: 336401
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false
type: Reaction

725880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

334787
local parameters: 958646
local parameters: 958644
notes: k1*PP1_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

727560
kinetic law: 333961
product: 333949
product: 333937
reactant: 333925
fast: false
reversible: false
type: Reaction

332743
stoichiometry: 1.0
species: 725580
type: SpeciesReference

334920
stoichiometry: 1.0
species: 724720
type: SpeciesReference

332889
local parameters: 958558
local parameters: 958556
notes: kf*PKA_slash_R2C2*cAMP-kb*PKA_slash_R2C2_minus_cAMP
type: KineticLaw

727980
kinetic law: 334981
product: 334969
reactant: 334957
reactant: 334945
fast: false
reversible: true
type: Reaction

332138
stoichiometry: 1.0
species: 724260
type: SpeciesReference

958489
units: 331331
value: 4.4999712E-15
type: LocalParameter

725860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

727960
kinetic law: 334933
product: 334920
product: 334907
reactant: 334895
fast: false
reversible: false
type: Reaction

958750
units: 331247
value: 1.44E-15
type: LocalParameter

958724
units: 331247
value: 4.05E-16
type: LocalParameter

331319
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

958539
units: 331247
value: 9.0E-15
type: LocalParameter

958575
units: 331247
value: 9.0E-16
type: LocalParameter

336944
stoichiometry: 1.0
species: 725520
type: SpeciesReference

332114
local parameters: 958519
local parameters: 958518
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*NMDAR-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

335406
stoichiometry: 1.0
species: 725140
type: SpeciesReference

MODEL9086953089
species: 725180
reaction: 728020
reaction: 726820
units def: 331380
reaction: 728580
substance units: 331380
is described by: http://identifiers.org/pubmed/16110334
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reaction: 726640
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reaction: 727100
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area units: area
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curated: false
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331994
stoichiometry: 1.0
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332477
stoichiometry: 1.0
species: 724880
type: SpeciesReference

724200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

334835
local parameters: 958647
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

334690
local parameters: 958641
local parameters: 958639
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

336123
stoichiometry: 1.0
species: 726280
type: SpeciesReference

958594
units: 331331
value: 5.99994E-17
type: LocalParameter

334799
stoichiometry: 1.0
species: 724740
type: SpeciesReference

725820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331718
stoichiometry: 1.0
species: 725020
type: SpeciesReference

958751
units: 331247
value: 3.6E-16
type: LocalParameter

336788
stoichiometry: 1.0
species: 725460
type: SpeciesReference

725840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958574
units: 331331
value: 2.2062942E-16
type: LocalParameter

958624
units: 331331
value: 5.81256E-17
type: LocalParameter

333216
stoichiometry: 1.0
species: 724060
type: SpeciesReference

335345
stoichiometry: 1.0
species: 725140
type: SpeciesReference

336848
stoichiometry: 1.0
species: 725560
type: SpeciesReference

958597
units: 331247
value: 8.1E-16
type: LocalParameter

726040
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 723980
type: Species

726060
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723980
type: Species

958726
units: 331210
value: 299.9976000192
type: LocalParameter

336183
stoichiometry: 1.0
species: 726280
type: SpeciesReference

332042
stoichiometry: 1.0
species: 725260
type: SpeciesReference

958690
units: 331331
value: 3.0779838E-17
type: LocalParameter

958577
units: 331331
value: 2.2062942E-16
type: LocalParameter

725900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 723960
type: Species

333768
local parameters: 958592
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

726840
kinetic law: 332295
product: 332283
reactant: 332271
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

726080
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 723960
type: Species

335662
local parameters: 958688
local parameters: 958687
notes: k1*CaMKII_minus_thr305_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

335430
stoichiometry: 1.0
species: 724900
type: SpeciesReference

334057
local parameters: 958607
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

958596
units: 331247
value: 3.24E-15
type: LocalParameter

958728
units: 331210
value: 300.001920012288
type: LocalParameter

958576
units: 331247
value: 2.25E-16
type: LocalParameter

958727
units: 331247
value: 1.8E-16
type: LocalParameter

726860
kinetic law: 332343
product: 332331
product: 332319
reactant: 332307
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

336449
stoichiometry: 1.0
species: 726080
type: SpeciesReference

958626
units: 331247
value: 7.50006E-16
type: LocalParameter

334372
stoichiometry: 1.0
species: 724620
type: SpeciesReference

336968
local parameters: 958751
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

724280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331501
stoichiometry: 1.0
species: 724460
type: SpeciesReference

958599
units: 331331
value: 5.399946E-16
type: LocalParameter

958647
units: 331247
value: 3.06E-18
type: LocalParameter

728260
kinetic law: 335662
product: 335649
reactant: 335637
reactant: 335625
fast: false
reversible: true
type: Reaction

728280
kinetic law: 335710
product: 335698
product: 335686
reactant: 335674
fast: false
reversible: false
type: Reaction

728620
kinetic law: 336533
product: 336521
reactant: 336509
reactant: 336497
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true
type: Reaction

958627
units: 331247
value: 1.8E-16
type: LocalParameter

724400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 723960
type: Species

724260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 723960
type: Species

958571
units: 331331
value: 2.2062942E-16
type: LocalParameter

724680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 723960
type: Species

958701
units: 331247
value: 1.224E-16
type: LocalParameter

728660
kinetic law: 336630
product: 336618
reactant: 336606
reactant: 336594
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true
type: Reaction

333374
local parameters: 958576
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

334763
stoichiometry: 1.0
species: 724720
type: SpeciesReference

723980
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

727400
kinetic law: 333575
product: 333563
product: 333550
reactant: 333538
fast: false
reversible: false
type: Reaction

958629
units: 331331
value: 5.81256E-17
type: LocalParameter

331416
stoichiometry: 1.0
species: 724260
type: SpeciesReference

334811
stoichiometry: 1.0
species: 724540
type: SpeciesReference

331790
stoichiometry: 1.0
species: 724600
type: SpeciesReference

958570
units: 331247
value: 9.0E-17
type: LocalParameter

958721
units: 331247
value: 8.0E-17
type: LocalParameter

332707
stoichiometry: 1.0
species: 725540
type: SpeciesReference

334106
local parameters: 958611
local parameters: 958609
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

958702
units: 331247
value: 3.06E-17
type: LocalParameter

726940
kinetic law: 332526
product: 332514
reactant: 332502
fast: false
reversible: true
type: Reaction

334457
stoichiometry: 1.0
species: 724580
type: SpeciesReference

958649
units: 331331
value: 3.420036E-19
type: LocalParameter

724780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 723960
type: Species

334726
stoichiometry: 1.0
species: 724620
type: SpeciesReference

727480
kinetic law: 333768
product: 333756
product: 333744
reactant: 333732
fast: false
reversible: false
type: Reaction

958573
units: 331247
value: 2.25E-16
type: LocalParameter

724380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 723960
type: Species

958722
units: 331247
value: 2.0E-17
type: LocalParameter

336764
stoichiometry: 1.0
species: 725660
type: SpeciesReference

331441
local parameters: 958490
local parameters: 958489
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

332792
stoichiometry: 1.0
species: 725700
type: SpeciesReference

336026
stoichiometry: 1.0
species: 725280
type: SpeciesReference

728200
kinetic law: 335515
product: 335502
product: 335490
reactant: 335478
fast: false
reversible: false
type: Reaction

335369
local parameters: 958676
local parameters: 958674
notes: k1*CaMKII_minus_thr286_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

334396
local parameters: 958626
local parameters: 958624
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

724340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333094
stoichiometry: 1.0
species: 725860
type: SpeciesReference

336292
local parameters: 958717
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

335686
stoichiometry: 1.0
species: 724880
type: SpeciesReference

726900
kinetic law: 332441
product: 332429
reactant: 332417
reactant: 332405
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

724740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

332453
stoichiometry: 1.0
species: 724840
type: SpeciesReference

333744
stoichiometry: 1.0
species: 724560
type: SpeciesReference

335917
stoichiometry: 1.0
species: 725080
type: SpeciesReference

335454
stoichiometry: 1.0
species: 725200
type: SpeciesReference

958572
units: 331247
value: 9.0E-16
type: LocalParameter

336668
stoichiometry: 1.0
species: 725620
type: SpeciesReference

333069
stoichiometry: 1.0
species: 725860
type: SpeciesReference

334081
stoichiometry: 1.0
species: 726120
type: SpeciesReference

958532
units: 331247
value: 1.0E-18
type: LocalParameter

334142
stoichiometry: 1.0
species: 726120
type: SpeciesReference

958685
units: 331247
value: 8.0E-18
type: LocalParameter

958496
units: 331247
value: 9.0E-16
type: LocalParameter

958743
units: 331331
value: 1.1339838E-16
type: LocalParameter

958580
units: 331331
value: 2.2062942E-16
type: LocalParameter

332174
stoichiometry: 1.0
species: 725980
type: SpeciesReference

332006
stoichiometry: 1.0
species: 724840
type: SpeciesReference

724300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333337
stoichiometry: 1.0
species: 724080
type: SpeciesReference

331946
stoichiometry: 1.0
species: 724720
type: SpeciesReference

727640
kinetic law: 334154
product: 334142
product: 334130
reactant: 334118
fast: false
reversible: false
type: Reaction

724320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333901
stoichiometry: 1.0
species: 724240
type: SpeciesReference

958646
units: 331247
value: 1.224E-17
type: LocalParameter

334033
stoichiometry: 1.0
species: 724320
type: SpeciesReference

336680
local parameters: 958736
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

958495
units: 331331
value: 3.2400162E-16
type: LocalParameter

958686
units: 331247
value: 2.0E-18
type: LocalParameter

958533
units: 331331
value: 4.1849946E-17
type: LocalParameter

958581
units: 331247
value: 9.0E-16
type: LocalParameter

335832
stoichiometry: 1.0
species: 725280
type: SpeciesReference

725480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333889
stoichiometry: 1.0
species: 724180
type: SpeciesReference

333143
stoichiometry: 1.0
species: 724180
type: SpeciesReference

335296
stoichiometry: 1.0
species: 724840
type: SpeciesReference

724900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

335223
local parameters: 958667
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

333325
local parameters: 958575
local parameters: 958574
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

724700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 723960
type: Species

334191
stoichiometry: 1.0
species: 724400
type: SpeciesReference

333816
local parameters: 958596
local parameters: 958594
notes: k1*PP1_PSD_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

333973
stoichiometry: 1.0
species: 724340
type: SpeciesReference

958683
units: 331247
value: 2.0E-18
type: LocalParameter

958530
units: 331331
value: 0.0
type: LocalParameter

958741
units: 331247
value: 1.5003E-16
type: LocalParameter

958494
units: 331247
value: 6.48E-15
type: LocalParameter

335649
stoichiometry: 1.0
species: 725240
type: SpeciesReference

335905
local parameters: 958697
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

334993
stoichiometry: 1.0
species: 724920
type: SpeciesReference

335698
stoichiometry: 1.0
species: 725140
type: SpeciesReference

332331
stoichiometry: 1.0
species: 725140
type: SpeciesReference

335784
stoichiometry: 1.0
species: 724540
type: SpeciesReference

728360
kinetic law: 335905
product: 335893
product: 335880
reactant: 335868
fast: false
reversible: false
type: Reaction

958558
units: 331247
value: 2.97E-15
type: LocalParameter

724980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

958644
units: 331331
value: 3.0779838E-18
type: LocalParameter

336353
stoichiometry: 1.0
species: 725440
type: SpeciesReference

958740
units: 331247
value: 6.003E-16
type: LocalParameter

958531
units: 331331
value: 4.9998E-15
type: LocalParameter

958684
units: 331331
value: 4.99998E-18
type: LocalParameter

332247
stoichiometry: 1.0
species: 724820
type: SpeciesReference

724940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

958493
units: 331283
value: 6.47990604E-15
type: LocalParameter

726560
kinetic law: 331633
product: 331621
reactant: 331609
reactant: 331597
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

336752
stoichiometry: 1.0
species: 725560
type: SpeciesReference

958559
units: 331331
value: 4.86E-15
type: LocalParameter

332865
stoichiometry: 1.0
species: 725460
type: SpeciesReference

728800
kinetic law: 336968
product: 336956
product: 336944
reactant: 336932
fast: false
reversible: false
type: Reaction

332767
stoichiometry: 1.0
species: 725660
type: SpeciesReference

334678
stoichiometry: 1.0
species: 724700
type: SpeciesReference

332804
local parameters: 958553
local parameters: 958552
notes: kf*AC_slash_PDE1*CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1
type: KineticLaw

958536
units: 331331
value: 0.0
type: LocalParameter

333660
stoichiometry: 1.0
species: 724040
type: SpeciesReference

958622
units: 331247
value: 4.5E-17
type: LocalParameter

331922
local parameters: 958511
local parameters: 958510
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

725400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

727000
kinetic law: 332635
product: 332623
reactant: 332611
fast: false
reversible: true
type: Reaction

724040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 723960
type: Species

958492
units: 331247
value: 9.0E-18
type: LocalParameter

958681
units: 331247
value: 8.0E-18
type: LocalParameter

333045
stoichiometry: 1.0
species: 725840
type: SpeciesReference

724060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335941
stoichiometry: 1.0
species: 725340
type: SpeciesReference

334166
stoichiometry: 1.0
species: 724340
type: SpeciesReference

958661
units: 331247
value: 2.0E-17
type: LocalParameter

332150
stoichiometry: 1.0
species: 725260
type: SpeciesReference

336159
stoichiometry: 1.0
species: 725400
type: SpeciesReference

334847
stoichiometry: 1.0
species: 725080
type: SpeciesReference

958556
units: 331331
value: 4.86E-15
type: LocalParameter

334506
stoichiometry: 1.0
species: 724660
type: SpeciesReference

331633
local parameters: 958498
local parameters: 958497
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

334252
local parameters: 958617
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

958642
units: 331247
value: 1.8E-16
type: LocalParameter

958537
units: 331247
value: 9.0E-15
type: LocalParameter

331982
stoichiometry: 1.0
species: 724880
type: SpeciesReference

333301
stoichiometry: 1.0
species: 724040
type: SpeciesReference

724020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

333865
local parameters: 958597
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

958621
units: 331247
value: 1.8E-16
type: LocalParameter

958491
units: 331331
value: 9.001692E-14
type: LocalParameter

958662
units: 331247
value: 5.0E-18
type: LocalParameter

335856
local parameters: 958696
local parameters: 958694
notes: k1*PP1_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

727320
kinetic law: 333374
product: 333361
product: 333349
reactant: 333337
fast: false
reversible: false
type: Reaction

335248
stoichiometry: 1.0
species: 725140
type: SpeciesReference

958641
units: 331247
value: 7.50006E-16
type: LocalParameter

724000
constant: true
size: 5.0E-15
spatial dimensions: 3.0
type: Compartment

724620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 723960
type: Species

728400
kinetic law: 336001
product: 335989
product: 335977
reactant: 335965
fast: false
reversible: false
type: Reaction

724080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958534
units: 331247
value: 9.0E-16
type: LocalParameter

332829
stoichiometry: 1.0
species: 725740
type: SpeciesReference

331838
stoichiometry: 2.0
species: 724160
type: SpeciesReference

331392
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

958554
units: 331247
value: 2.7E-14
type: LocalParameter

958490
units: 331247
value: 4.5E-16
type: LocalParameter

334883
local parameters: 958651
local parameters: 958649
notes: k1*PP1_PSD_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

727900
kinetic law: 334787
product: 334775
reactant: 334763
reactant: 334750
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

331235
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

958535
units: 331247
value: 5.0E-17
type: LocalParameter

728160
kinetic law: 335418
product: 335406
product: 335393
reactant: 335381
fast: false
reversible: false
type: Reaction

335893
stoichiometry: 1.0
species: 725280
type: SpeciesReference

727060
kinetic law: 332755
product: 332743
reactant: 332731
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true
type: Reaction

336642
stoichiometry: 1.0
species: 725640
type: SpeciesReference

727940
kinetic law: 334883
product: 334871
reactant: 334859
reactant: 334847
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

332841
local parameters: 958555
local parameters: 958554
notes: kf*cAMP-kb*AC_slash_cAMP_in_dend
type: KineticLaw

724180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

332223
stoichiometry: 1.0
species: 724860
type: SpeciesReference

725680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

727080
kinetic law: 332804
product: 332792
reactant: 332780
reactant: 332767
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true
type: Reaction

728140
kinetic law: 335369
product: 335357
reactant: 335345
reactant: 335333
fast: false
reversible: true
type: Reaction

336557
stoichiometry: 1.0
species: 725560
type: SpeciesReference

958555
units: 331247
value: 2.7E-14
type: LocalParameter

724660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 723960
type: Species

331742
stoichiometry: 1.0
species: 724560
type: SpeciesReference

335067
stoichiometry: 1.0
species: 724940
type: SpeciesReference

332490
local parameters: 958536
local parameters: 958535
notes: kf*CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_minus_PSD
type: KineticLaw

336884
stoichiometry: 1.0
species: 725540
type: SpeciesReference

728440
kinetic law: 336099
product: 336087
product: 336075
reactant: 336063
fast: false
reversible: false
type: Reaction

958552
units: 331331
value: 6.479838E-14
type: LocalParameter

334203
local parameters: 958616
local parameters: 958614
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

333502
stoichiometry: 1.0
species: 724040
type: SpeciesReference

958513
units: 331247
value: 9.0E-17
type: LocalParameter

333841
stoichiometry: 1.0
species: 725080
type: SpeciesReference

727660
kinetic law: 334203
product: 334191
reactant: 334179
reactant: 334166
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

958666
units: 331247
value: 8.0E-17
type: LocalParameter

335965
stoichiometry: 1.0
species: 725340
type: SpeciesReference

725460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

727620
kinetic law: 334106
product: 334093
reactant: 334081
reactant: 334069
fast: false
reversible: true
type: Reaction

728780
kinetic law: 336920
product: 336908
reactant: 336896
reactant: 336884
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true
type: Reaction

334276
stoichiometry: 1.0
species: 726140
type: SpeciesReference

726480
kinetic law: 331441
product: 331428
reactant: 331416
reactant: 331404
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

334933
local parameters: 958652
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

958553
units: 331247
value: 4.5E-16
type: LocalParameter

958512
units: 331331
value: 5.399946E-14
type: LocalParameter

726880
kinetic law: 332392
product: 332380
reactant: 332368
reactant: 332356
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

333949
stoichiometry: 1.0
species: 724180
type: SpeciesReference

333684
stoichiometry: 1.0
species: 724540
type: SpeciesReference

335163
stoichiometry: 1.0
species: 724960
type: SpeciesReference

728760
kinetic law: 336872
product: 336860
product: 336848
reactant: 336836
fast: false
reversible: false
type: Reaction

336099
local parameters: 958707
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

335600
stoichiometry: 1.0
species: 725140
type: SpeciesReference

333253
stoichiometry: 1.0
species: 724280
type: SpeciesReference

336075
stoichiometry: 1.0
species: 725120
type: SpeciesReference

334566
stoichiometry: 1.0
species: 724620
type: SpeciesReference

958550
units: 331247
value: 9.0E-19
type: LocalParameter

332997
stoichiometry: 1.0
species: 725460
type: SpeciesReference

958511
units: 331247
value: 9.0E-17
type: LocalParameter

332635
local parameters: 958545
local parameters: 958544
notes: kf*PKC_minus_control-kb*PKC_minus_active
type: KineticLaw

728380
kinetic law: 335953
product: 335941
reactant: 335929
reactant: 335917
fast: false
reversible: true
type: Reaction

331343
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

726580
kinetic law: 331682
product: 331670
reactant: 331658
reactant: 331645
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

724960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

332551
stoichiometry: 1.0
species: 725040
type: SpeciesReference

335564
local parameters: 958685
local parameters: 958684
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

335515
local parameters: 958683
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

724220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958664
units: 331331
value: 1.99998E-19
type: LocalParameter

726540
kinetic law: 331585
product: 331573
reactant: 331561
reactant: 331549
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

958551
units: 331247
value: 0.0
type: LocalParameter

726500
kinetic law: 331489
product: 331477
reactant: 331465
reactant: 331453
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

336533
local parameters: 958730
local parameters: 958729
notes: k1*cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

724240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

336485
local parameters: 958728
local parameters: 958727
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

332937
local parameters: 958560
local parameters: 958559
notes: kf*PKA_slash_R2C2_minus_cAMP*cAMP-kb*PKA_slash_R2C2_minus_cAMP2
type: KineticLaw

728340
kinetic law: 335856
product: 335844
reactant: 335832
reactant: 335820
fast: false
reversible: true
type: Reaction

958510
units: 331283
value: 9.00720324E-13
type: LocalParameter

331814
stoichiometry: 1.0
species: 724540
type: SpeciesReference

727720
kinetic law: 334348
product: 334336
product: 334324
reactant: 334312
fast: false
reversible: false
type: Reaction

727340
kinetic law: 333425
product: 333412
reactant: 333399
reactant: 333386
fast: false
reversible: true
type: Reaction

724580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335272
local parameters: 958671
local parameters: 958669
notes: k1*CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

333997
stoichiometry: 1.0
species: 724360
type: SpeciesReference

336618
stoichiometry: 1.0
species: 725640
type: SpeciesReference

958669
units: 331331
value: 4.99998E-18
type: LocalParameter

335115
stoichiometry: 1.0
species: 726160
type: SpeciesReference

958689
units: 331247
value: 2.0E-18
type: LocalParameter

335043
stoichiometry: 1.0
species: 724840
type: SpeciesReference

332283
stoichiometry: 1.0
species: 724020
type: SpeciesReference

331766
stoichiometry: 1.0
species: 724580
type: SpeciesReference

726200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723980
type: Species

725760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 723960
type: Species

332199
stoichiometry: 1.0
species: 725260
type: SpeciesReference

336860
stoichiometry: 1.0
species: 725700
type: SpeciesReference

333925
stoichiometry: 1.0
species: 724240
type: SpeciesReference

334542
local parameters: 958632
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

335187
stoichiometry: 1.0
species: 724960
type: SpeciesReference

333792
stoichiometry: 1.0
species: 724180
type: SpeciesReference

727300
kinetic law: 333325
product: 333313
reactant: 333301
reactant: 333289
fast: false
reversible: true
type: Reaction

333648
stoichiometry: 1.0
species: 724260
type: SpeciesReference

335989
stoichiometry: 1.0
species: 725280
type: SpeciesReference

334957
stoichiometry: 1.0
species: 726160
type: SpeciesReference

725420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

331658
stoichiometry: 1.0
species: 725040
type: SpeciesReference

332973
stoichiometry: 1.0
species: 725820
type: SpeciesReference

332659
stoichiometry: 1.0
species: 725500
type: SpeciesReference

728420
kinetic law: 336051
product: 336038
reactant: 336026
reactant: 336014
fast: false
reversible: true
type: Reaction

724640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 723960
type: Species

725660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 723960
type: Species

331850
stoichiometry: 1.0
species: 724800
type: SpeciesReference

958667
units: 331247
value: 2.0E-17
type: LocalParameter

335308
stoichiometry: 1.0
species: 725140
type: SpeciesReference

336051
local parameters: 958706
local parameters: 958704
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

333277
local parameters: 958573
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

958687
units: 331331
value: 4.99998E-18
type: LocalParameter

727920
kinetic law: 334835
product: 334823
product: 334811
reactant: 334799
fast: false
reversible: false
type: Reaction

727280
kinetic law: 333277
product: 333265
product: 333253
reactant: 333240
fast: false
reversible: false
type: Reaction

335005
stoichiometry: 1.0
species: 724900
type: SpeciesReference

726260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723960
type: Species

336461
stoichiometry: 1.0
species: 725460
type: SpeciesReference

726280
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

336377
stoichiometry: 1.0
species: 726280
type: SpeciesReference

331682
local parameters: 958500
local parameters: 958499
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD
type: KineticLaw

333464
stoichiometry: 1.0
species: 724040
type: SpeciesReference

331368
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

728560
kinetic law: 336389
product: 336377
product: 336365
reactant: 336353
fast: false
reversible: false
type: Reaction

727240
kinetic law: 333180
product: 333168
reactant: 333156
reactant: 333143
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true
type: Reaction

335625
stoichiometry: 1.0
species: 725980
type: SpeciesReference

335588
stoichiometry: 1.0
species: 725980
type: SpeciesReference

958688
units: 331247
value: 8.0E-18
type: LocalParameter

727260
kinetic law: 333228
product: 333216
reactant: 333204
reactant: 333192
fast: false
reversible: true
type: Reaction

335539
stoichiometry: 1.0
species: 725140
type: SpeciesReference

332356
stoichiometry: 1.0
species: 725080
type: SpeciesReference

333563
stoichiometry: 1.0
species: 724040
type: SpeciesReference

335381
stoichiometry: 1.0
species: 725180
type: SpeciesReference

958719
units: 331331
value: 3.12498E-19
type: LocalParameter

334591
local parameters: 958636
local parameters: 958634
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

332405
stoichiometry: 1.0
species: 724500
type: SpeciesReference

336207
stoichiometry: 1.0
species: 724840
type: SpeciesReference

334336
stoichiometry: 1.0
species: 726140
type: SpeciesReference

332780
stoichiometry: 1.0
species: 724020
type: SpeciesReference

958509
units: 331247
value: 9.0E-17
type: LocalParameter

333438
stoichiometry: 1.0
species: 724100
type: SpeciesReference

334420
stoichiometry: 1.0
species: 724540
type: SpeciesReference

728460
kinetic law: 336147
product: 336135
reactant: 336123
reactant: 336111
fast: false
reversible: true
type: Reaction

336728
local parameters: 958740
local parameters: 958738
notes: k1*cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

336812
stoichiometry: 1.0
species: 725720
type: SpeciesReference

333180
local parameters: 958570
local parameters: 958569
notes: kf*PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA
type: KineticLaw

336304
stoichiometry: 1.0
species: 724880
type: SpeciesReference

332695
stoichiometry: 1.0
species: 725520
type: SpeciesReference

332599
local parameters: 958543
local parameters: 958542
notes: kf*basal_CaMKII_PSD_control-kb*basal_CaMKII_PSD
type: KineticLaw

331874
local parameters: 958509
local parameters: 958508
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*CaNAB_minus_Ca4
type: KineticLaw

332078
stoichiometry: 1.0
species: 724300
type: SpeciesReference

334493
local parameters: 958631
local parameters: 958629
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

332719
local parameters: 958549
local parameters: 958548
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2
type: KineticLaw

336267
stoichiometry: 1.0
species: 724820
type: SpeciesReference

958506
units: 331247
value: 9.0E-17
type: LocalParameter

333624
local parameters: 958586
local parameters: 958584
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

958717
units: 331247
value: 5.0E-18
type: LocalParameter

958716
units: 331247
value: 2.0E-17
type: LocalParameter

331561
stoichiometry: 1.0
species: 724160
type: SpeciesReference

332319
stoichiometry: 1.0
species: 725060
type: SpeciesReference

728320
kinetic law: 335808
product: 335796
product: 335784
reactant: 335771
fast: false
reversible: false
type: Reaction

333386
stoichiometry: 1.0
species: 724320
type: SpeciesReference

334603
stoichiometry: 1.0
species: 724680
type: SpeciesReference

335722
stoichiometry: 1.0
species: 724560
type: SpeciesReference

334009
local parameters: 958606
local parameters: 958604
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

331477
stoichiometry: 1.0
species: 724300
type: SpeciesReference

958507
units: 331331
value: 0.0
type: LocalParameter

727680
kinetic law: 334252
product: 334240
product: 334228
reactant: 334215
fast: false
reversible: false
type: Reaction

958659
units: 331331
value: 4.99998E-20
type: LocalParameter

958508
units: 331283
value: 3.24008424E-16
type: LocalParameter

335734
stoichiometry: 1.0
species: 725280
type: SpeciesReference

331513
stoichiometry: 2.0
species: 724160
type: SpeciesReference

727040
kinetic law: 332719
product: 332707
reactant: 332695
notes: Random rate.
fast: false
reversible: true
type: Reaction

727020
kinetic law: 332683
product: 332671
reactant: 332659
reactant: 332647
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true
type: Reaction

332913
stoichiometry: 1.0
species: 725460
type: SpeciesReference

958504
units: 331331
value: 4.4998254E-14
type: LocalParameter

335868
stoichiometry: 1.0
species: 725320
type: SpeciesReference

728120
kinetic law: 335321
product: 335308
product: 335296
reactant: 335284
fast: false
reversible: false
type: Reaction

335127
local parameters: 958662
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

724460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 723960
type: Species

728100
kinetic law: 335272
product: 335260
reactant: 335248
reactant: 335236
fast: false
reversible: true
type: Reaction

332429
stoichiometry: 1.0
species: 724020
type: SpeciesReference

726720
kinetic law: 332018
product: 332006
reactant: 331994
reactant: 331982
fast: false
reversible: true
type: Reaction

336582
local parameters: 958731
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

334228
stoichiometry: 1.0
species: 724320
type: SpeciesReference

332671
stoichiometry: 1.0
species: 725480
type: SpeciesReference

332575
stoichiometry: 1.0
species: 726060
type: SpeciesReference

332054
stoichiometry: 1.0
species: 724840
type: SpeciesReference

727360
kinetic law: 333477
product: 333464
product: 333451
reactant: 333438
fast: false
reversible: false
type: Reaction

958505
units: 331247
value: 9.0E-18
type: LocalParameter

331898
stoichiometry: 2.0
species: 724160
type: SpeciesReference

333587
stoichiometry: 1.0
species: 724440
type: SpeciesReference

336171
stoichiometry: 1.0
species: 724900
type: SpeciesReference

332380
stoichiometry: 1.0
species: 725100
type: SpeciesReference

332514
stoichiometry: 1.0
species: 724160
type: SpeciesReference

334640
local parameters: 958637
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

335333
stoichiometry: 1.0
species: 724860
type: SpeciesReference

336836
stoichiometry: 1.0
species: 725720
type: SpeciesReference

728540
kinetic law: 336341
product: 336329
reactant: 336316
reactant: 336304
fast: false
reversible: true
type: Reaction

333600
stoichiometry: 1.0
species: 724040
type: SpeciesReference

336243
local parameters: 958716
local parameters: 958714
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

331670
stoichiometry: 1.0
species: 725000
type: SpeciesReference

725700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

724160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 723960
type: Species

333526
local parameters: 958581
local parameters: 958580
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

958503
units: 331247
value: 1.0E-16
type: LocalParameter

725800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335758
local parameters: 958691
local parameters: 958690
notes: k1*PP1_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

331537
local parameters: 958494
local parameters: 958493
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2
type: KineticLaw

725740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 724000
type: Species

728500
kinetic law: 336243
product: 336231
reactant: 336219
reactant: 336207
fast: false
reversible: true
type: Reaction

724560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

331585
local parameters: 958496
local parameters: 958495
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3
type: KineticLaw

724140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

334312
stoichiometry: 1.0
species: 724420
type: SpeciesReference

728480
kinetic law: 336195
product: 336183
product: 336171
reactant: 336159
fast: false
reversible: false
type: Reaction

724880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

333361
stoichiometry: 1.0
species: 724040
type: SpeciesReference

333204
stoichiometry: 1.0
species: 724040
type: SpeciesReference

335357
stoichiometry: 1.0
species: 725180
type: SpeciesReference

726020
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 723960
type: Species

728080
kinetic law: 335223
product: 335211
product: 335199
reactant: 335187
fast: false
reversible: false
type: Reaction

726000
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723960
type: Species

724720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

334408
stoichiometry: 1.0
species: 724640
type: SpeciesReference

334738
local parameters: 958642
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

958589
units: 331331
value: 5.399946E-16
type: LocalParameter

331259
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

958529
units: 331247
value: 1.0E-17
type: LocalParameter

958738
units: 331331
value: 1.8900054E-17
type: LocalParameter

334469
stoichiometry: 1.0
species: 724620
type: SpeciesReference

336195
local parameters: 958712
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

332030
stoichiometry: 1.0
species: 724280
type: SpeciesReference

334069
stoichiometry: 1.0
species: 724280
type: SpeciesReference

333829
stoichiometry: 1.0
species: 724220
type: SpeciesReference

958711
units: 331247
value: 2.4E-16
type: LocalParameter

335442
stoichiometry: 1.0
species: 725140
type: SpeciesReference

333756
stoichiometry: 1.0
species: 724180
type: SpeciesReference

333168
stoichiometry: 1.0
species: 725920
type: SpeciesReference

336280
stoichiometry: 1.0
species: 726280
type: SpeciesReference

958614
units: 331331
value: 7.714278E-18
type: LocalParameter

333082
local parameters: 958566
local parameters: 958565
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2C_minus_cAMP4
type: KineticLaw

334360
stoichiometry: 1.0
species: 724560
type: SpeciesReference

958528
units: 331247
value: 5.4E-15
type: LocalParameter

336437
local parameters: 958726
local parameters: 958724
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

336038
stoichiometry: 1.0
species: 725360
type: SpeciesReference

334775
stoichiometry: 1.0
species: 724740
type: SpeciesReference

333118
stoichiometry: 1.0
species: 725880
type: SpeciesReference

726980
kinetic law: 332599
product: 332587
reactant: 332575
fast: false
reversible: true
type: Reaction

332731
stoichiometry: 1.0
species: 725620
type: SpeciesReference

727100
kinetic law: 332841
product: 332829
reactant: 332817
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true
type: Reaction

728720
kinetic law: 336776
product: 336764
product: 336752
reactant: 336740
fast: false
reversible: false
type: Reaction

725500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 723960
type: Species

724920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

958639
units: 331331
value: 6.4584E-18
type: LocalParameter

725520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

728740
kinetic law: 336824
product: 336812
reactant: 336800
reactant: 336788
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true
type: Reaction

958611
units: 331247
value: 1.8E-16
type: LocalParameter

335418
local parameters: 958677
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

332126
stoichiometry: 1.0
species: 724880
type: SpeciesReference

332465
stoichiometry: 1.0
species: 725020
type: SpeciesReference

727800
kinetic law: 334542
product: 334530
product: 334518
reactant: 334506
fast: false
reversible: false
type: Reaction

336932
stoichiometry: 1.0
species: 725960
type: SpeciesReference

958736
units: 331247
value: 1.8E-15
type: LocalParameter

958527
units: 331247
value: 5.4E-15
type: LocalParameter

958587
units: 331247
value: 2.25E-16
type: LocalParameter

726180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

333021
stoichiometry: 1.0
species: 725840
type: SpeciesReference

727840
kinetic law: 334640
product: 334627
product: 334615
reactant: 334603
fast: false
reversible: false
type: Reaction

334118
stoichiometry: 1.0
species: 724380
type: SpeciesReference

336135
stoichiometry: 1.0
species: 725400
type: SpeciesReference

334823
stoichiometry: 1.0
species: 724720
type: SpeciesReference

332539
stoichiometry: 1.0
species: 726040
type: SpeciesReference

332090
stoichiometry: 1.0
species: 725260
type: SpeciesReference

958612
units: 331247
value: 4.5E-17
type: LocalParameter

727820
kinetic law: 334591
product: 334578
reactant: 334566
reactant: 334554
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

336509
stoichiometry: 1.0
species: 725580
type: SpeciesReference

958586
units: 331247
value: 9.0E-16
type: LocalParameter

958526
units: 331247
value: 1.0E-18
type: LocalParameter

334714
stoichiometry: 1.0
species: 725120
type: SpeciesReference

958637
units: 331247
value: 1.8E-16
type: LocalParameter

725280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

958714
units: 331331
value: 7.8126E-20
type: LocalParameter

334445
local parameters: 958627
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

336704
stoichiometry: 1.0
species: 725660
type: SpeciesReference

336776
local parameters: 958741
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

958499
units: 331331
value: 3.6E-17
type: LocalParameter

958617
units: 331247
value: 5.4E-16
type: LocalParameter

333490
stoichiometry: 1.0
species: 724320
type: SpeciesReference

726700
kinetic law: 331970
product: 331958
reactant: 331946
reactant: 331934
fast: false
reversible: true
type: Reaction

333228
local parameters: 958572
local parameters: 958571
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

726740
kinetic law: 332066
product: 332054
reactant: 332042
reactant: 332030
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true
type: Reaction

334384
stoichiometry: 1.0
species: 724640
type: SpeciesReference

958619
units: 331331
value: 6.428808E-19
type: LocalParameter

336014
stoichiometry: 1.0
species: 725100
type: SpeciesReference

724480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 723980
type: Species

958584
units: 331331
value: 2.2062942E-16
type: LocalParameter

958735
units: 331247
value: 7.2E-15
type: LocalParameter

335929
stoichiometry: 1.0
species: 725280
type: SpeciesReference

335466
local parameters: 958681
local parameters: 958679
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

725320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

335674
stoichiometry: 1.0
species: 725240
type: SpeciesReference

332441
local parameters: 958534
local parameters: 958533
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4
type: KineticLaw

333732
stoichiometry: 1.0
species: 724200
type: SpeciesReference

332102
stoichiometry: 1.0
species: 724820
type: SpeciesReference

958712
units: 331247
value: 6.0E-17
type: LocalParameter

331307
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

334750
stoichiometry: 1.0
species: 724560
type: SpeciesReference

725240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

336956
stoichiometry: 1.0
species: 725940
type: SpeciesReference

331453
stoichiometry: 1.0
species: 724340
type: SpeciesReference

333412
stoichiometry: 1.0
species: 724100
type: SpeciesReference

336413
stoichiometry: 1.0
species: 725460
type: SpeciesReference

725260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 723980
type: Species

958497
units: 331283
value: 7.2E-16
type: LocalParameter

725220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

331404
stoichiometry: 1.0
species: 724020
type: SpeciesReference

727860
kinetic law: 334690
product: 334678
reactant: 334665
reactant: 334652
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

958636
units: 331247
value: 7.50006E-16
type: LocalParameter

725720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723960
type: Species

726240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 723960
type: Species

334627
stoichiometry: 1.0
species: 724620
type: SpeciesReference

958733
units: 331331
value: 4.5359838E-16
type: LocalParameter

958582
units: 331247
value: 2.25E-16
type: LocalParameter

331706
stoichiometry: 1.0
species: 725040
type: SpeciesReference

726220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 723980
type: Species

726640
kinetic law: 331826
product: 331814
product: 331802
reactant: 331790
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

727880
kinetic law: 334738
product: 334726
product: 334714
reactant: 334702
fast: false
reversible: false
type: Reaction

725200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 723980
type: Species

333451
stoichiometry: 1.0
species: 724340
type: SpeciesReference

958616
units: 331247
value: 2.16E-15
type: LocalParameter

728520
kinetic law: 336292
product: 336280
product: 336267
reactant: 336255
fast: false
reversible: false
type: Reaction

336111
stoichiometry: 1.0
species: 724860
type: SpeciesReference

958498
units: 331247
value: 7.2E-16
type: LocalParameter