036965
units: 319142
value: 2.2062942E-16
type: LocalParameter

710781
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

323400
stoichiometry: 1.0
species: 711461
type: SpeciesReference

320713
local parameters: 036973
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

037057
units: 319057
value: 8.0E-17
type: LocalParameter

037100
units: 319142
value: 3.420036E-18
type: LocalParameter

711121
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 710661
type: Species

036936
units: 319142
value: 4.99998E-16
type: LocalParameter

321733
local parameters: 037027
local parameters: 037025
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

320616
local parameters: 036970
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

321522
stoichiometry: 1.0
species: 711281
type: SpeciesReference

036955
units: 319142
value: 4.1849946E-17
type: LocalParameter

322003
stoichiometry: 1.0
species: 711361
type: SpeciesReference

322280
stoichiometry: 1.0
species: 711521
type: SpeciesReference

037110
units: 319142
value: 7.8126E-20
type: LocalParameter

323160
stoichiometry: 1.0
species: 711921
type: SpeciesReference

714181
kinetic law: 323136
product: 323124
product: 323112
reactant: 323100
fast: false
reversible: false
type: Reaction

711141
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

713381
kinetic law: 321196
product: 321183
product: 321171
reactant: 321159
fast: false
reversible: false
type: Reaction

711761
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

322172
local parameters: 037048
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

320297
stoichiometry: 1.0
species: 711521
type: SpeciesReference

319215
stoichiometry: 1.0
species: 710681
type: SpeciesReference

037043
units: 319057
value: 3.06E-18
type: LocalParameter

321123
stoichiometry: 1.0
species: 712201
type: SpeciesReference

321606
stoichiometry: 1.0
species: 711261
type: SpeciesReference

036935
units: 319057
value: 9.0E-17
type: LocalParameter

711661
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

712801
kinetic law: 319836
product: 319824
reactant: 319812
reactant: 319800
fast: false
reversible: true
type: Reaction

036945
units: 319142
value: 5.4E-21
type: LocalParameter

322088
stoichiometry: 1.0
species: 711501
type: SpeciesReference

712281
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661
type: Species

323388
stoichiometry: 1.0
species: 712061
type: SpeciesReference

321087
stoichiometry: 1.0
species: 710841
type: SpeciesReference

711561
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

714301
kinetic law: 323425
product: 323413
product: 323400
reactant: 323388
fast: false
reversible: false
type: Reaction

321270
stoichiometry: 1.0
species: 710941
type: SpeciesReference

036966
units: 319057
value: 9.0E-16
type: LocalParameter

712741
kinetic law: 319689
product: 319677
reactant: 319664
reactant: 319652
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

322932
stoichiometry: 1.0
species: 711921
type: SpeciesReference

323413
stoichiometry: 1.0
species: 712361
type: SpeciesReference

322510
local parameters: 037067
local parameters: 037065
notes: k1*CaMKII_minus_thr286_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

711721
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

036947
units: 319057
value: 1.0E-18
type: LocalParameter

322848
local parameters: 037083
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

322474
stoichiometry: 1.0
species: 711501
type: SpeciesReference

711521
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

036937
units: 319057
value: 0.0
type: LocalParameter

712201
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

319410
stoichiometry: 1.0
species: 711121
type: SpeciesReference

036956
units: 319057
value: 9.0E-16
type: LocalParameter

712221
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710641
type: Species

713721
kinetic law: 322027
product: 322015
reactant: 322003
reactant: 321991
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

320773
stoichiometry: 1.0
species: 710781
type: SpeciesReference

322860
stoichiometry: 1.0
species: 711201
type: SpeciesReference

037042
units: 319057
value: 1.224E-17
type: LocalParameter

036946
units: 319142
value: 1.00002E-14
type: LocalParameter

711461
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

319567
stoichiometry: 1.0
species: 710701
type: SpeciesReference

321510
stoichiometry: 1.0
species: 711261
type: SpeciesReference

320628
stoichiometry: 1.0
species: 710961
type: SpeciesReference

036948
units: 319057
value: 5.4E-15
type: LocalParameter

322160
stoichiometry: 1.0
species: 712241
type: SpeciesReference

323172
stoichiometry: 1.0
species: 712001
type: SpeciesReference

036967
units: 319057
value: 2.25E-16
type: LocalParameter

322015
stoichiometry: 1.0
species: 711401
type: SpeciesReference

037112
units: 319057
value: 2.0E-17
type: LocalParameter

712161
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 710661
type: Species

320701
stoichiometry: 1.0
species: 710701
type: SpeciesReference

036953
units: 319142
value: 4.9998E-15
type: LocalParameter

036933
units: 319057
value: 9.0E-17
type: LocalParameter

712141
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 710641
type: Species

321171
stoichiometry: 1.0
species: 710961
type: SpeciesReference

322076
local parameters: 037043
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

321099
local parameters: 036993
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

323376
local parameters: 037112
local parameters: 037110
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

323451
stoichiometry: 1.0
species: 712361
type: SpeciesReference

321111
stoichiometry: 1.0
species: 710981
type: SpeciesReference

320285
stoichiometry: 1.0
species: 711661
type: SpeciesReference

319227
stoichiometry: 1.0
species: 710901
type: SpeciesReference

322462
local parameters: 037063
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

037058
units: 319057
value: 2.0E-17
type: LocalParameter

322450
stoichiometry: 1.0
species: 711781
type: SpeciesReference

036968
units: 319142
value: 2.2062942E-16
type: LocalParameter

036954
units: 319057
value: 1.0E-18
type: LocalParameter

322522
stoichiometry: 1.0
species: 711821
type: SpeciesReference

037040
units: 319142
value: 3.420036E-19
type: LocalParameter

322944
local parameters: 037088
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

037068
units: 319057
value: 2.0E-18
type: LocalParameter

322100
stoichiometry: 1.0
species: 712241
type: SpeciesReference

036934
units: 319142
value: 5.399946E-14
type: LocalParameter

319579
stoichiometry: 1.0
species: 711221
type: SpeciesReference

036969
units: 319057
value: 9.0E-16
type: LocalParameter

712121
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710641
type: Species

712101
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

320104
stoichiometry: 1.0
species: 710681
type: SpeciesReference

319422
stoichiometry: 2.0
species: 711681
type: SpeciesReference

320785
stoichiometry: 1.0
species: 711081
type: SpeciesReference

037030
units: 319142
value: 6.4584E-18
type: LocalParameter

322872
stoichiometry: 1.0
species: 711921
type: SpeciesReference

037067
units: 319057
value: 8.0E-18
type: LocalParameter

322824
stoichiometry: 1.0
species: 711501
type: SpeciesReference

322196
stoichiometry: 1.0
species: 712241
type: SpeciesReference

323463
stoichiometry: 1.0
species: 712081
type: SpeciesReference

319519
stoichiometry: 1.0
species: 711681
type: SpeciesReference

037053
units: 319057
value: 5.0E-18
type: LocalParameter

713641
kinetic law: 321835
product: 321823
reactant: 321811
reactant: 321798
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

710801
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

713501
kinetic law: 321486
product: 321474
product: 321462
reactant: 321450
fast: false
reversible: false
type: Reaction

323364
stoichiometry: 1.0
species: 712061
type: SpeciesReference

320493
stoichiometry: 1.0
species: 710921
type: SpeciesReference

037033
units: 319057
value: 1.8E-16
type: LocalParameter

323438
stoichiometry: 1.0
species: 711521
type: SpeciesReference

320091
stoichiometry: 1.0
species: 711661
type: SpeciesReference

036941
units: 319057
value: 0.0
type: LocalParameter

036931
units: 319057
value: 9.0E-17
type: LocalParameter

713181
kinetic law: 320713
product: 320701
product: 320689
reactant: 320677
fast: false
reversible: false
type: Reaction

037047
units: 319057
value: 2.4E-16
type: LocalParameter

713441
kinetic law: 321342
product: 321330
reactant: 321318
reactant: 321306
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

037113
units: 319057
value: 5.0E-18
type: LocalParameter

319848
stoichiometry: 1.0
species: 710921
type: SpeciesReference

710701
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 710641
type: Species

320007
stoichiometry: 1.0
species: 711081
type: SpeciesReference

320797
stoichiometry: 1.0
species: 710701
type: SpeciesReference

320140
stoichiometry: 1.0
species: 711701
type: SpeciesReference

322884
stoichiometry: 1.0
species: 711941
type: SpeciesReference

037052
units: 319057
value: 2.0E-17
type: LocalParameter

713481
kinetic law: 321438
product: 321426
reactant: 321414
reactant: 321402
fast: false
reversible: true
type: Reaction

037103
units: 319057
value: 3.06E-17
type: LocalParameter

321746
stoichiometry: 1.0
species: 711321
type: SpeciesReference

037032
units: 319057
value: 7.50006E-16
type: LocalParameter

321294
local parameters: 037003
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

710841
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0185185185185185
initial amount: NaN
in compartment: 710641
type: Species

036942
units: 319057
value: 3.0E-18
type: LocalParameter

322534
stoichiometry: 1.0
species: 711521
type: SpeciesReference

711481
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

713101
kinetic law: 320517
product: 320505
product: 320493
reactant: 320481
fast: false
reversible: false
type: Reaction

322498
stoichiometry: 1.0
species: 711821
type: SpeciesReference

321871
stoichiometry: 1.0
species: 711261
type: SpeciesReference

320517
local parameters: 036967
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

036932
units: 319093
value: 9.00720324E-13
type: LocalParameter

323352
stoichiometry: 1.0
species: 712361
type: SpeciesReference

037065
units: 319142
value: 4.99998E-18
type: LocalParameter

036957
units: 319057
value: 5.0E-17
type: LocalParameter

714081
kinetic law: 322896
product: 322884
reactant: 322872
reactant: 322860
fast: false
reversible: true
type: Reaction

037102
units: 319057
value: 1.224E-16
type: LocalParameter

322836
stoichiometry: 1.0
species: 711781
type: SpeciesReference

322184
stoichiometry: 1.0
species: 711481
type: SpeciesReference

713781
kinetic law: 322172
product: 322160
product: 322148
reactant: 322136
fast: false
reversible: false
type: Reaction

319507
stoichiometry: 1.0
species: 711641
type: SpeciesReference

323475
local parameters: 037117
local parameters: 037115
notes: k1*CaMKII_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

037055
units: 319142
value: 1.99998E-19
type: LocalParameter

323268
stoichiometry: 1.0
species: 712041
type: SpeciesReference

037035
units: 319142
value: 3.0779838E-18
type: LocalParameter

320604
stoichiometry: 1.0
species: 710701
type: SpeciesReference

714061
kinetic law: 322848
product: 322836
product: 322824
reactant: 322812
fast: false
reversible: false
type: Reaction

713401
kinetic law: 321245
product: 321233
reactant: 321220
reactant: 321208
fast: false
reversible: true
type: Reaction

036943
units: 319142
value: 5.4E-21
type: LocalParameter

036958
units: 319142
value: 0.0
type: LocalParameter

037045
units: 319142
value: 6.0E-19
type: LocalParameter

320481
stoichiometry: 1.0
species: 710721
type: SpeciesReference

322896
local parameters: 037087
local parameters: 037085
notes: k1*PP1_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

714001
kinetic law: 322704
product: 322692
reactant: 322680
reactant: 322668
fast: false
reversible: true
type: Reaction

714021
kinetic law: 322752
product: 322740
product: 322728
reactant: 322716
fast: false
reversible: false
type: Reaction

319836
local parameters: 036937
local parameters: 036936
notes: kf*CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

712961
kinetic law: 320213
product: 320201
reactant: 320188
reactant: 320176
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

037115
units: 319142
value: 3.12498E-19
type: LocalParameter

320019
stoichiometry: 1.0
species: 711901
type: SpeciesReference

713581
kinetic law: 321680
product: 321667
product: 321654
reactant: 321642
fast: false
reversible: false
type: Reaction

322486
stoichiometry: 1.0
species: 711781
type: SpeciesReference

322208
stoichiometry: 1.0
species: 711581
type: SpeciesReference

321720
stoichiometry: 1.0
species: 711321
type: SpeciesReference

036944
units: 319057
value: 3.0E-18
type: LocalParameter

320505
stoichiometry: 1.0
species: 710701
type: SpeciesReference

712941
kinetic law: 320164
product: 320152
product: 320140
reactant: 320128
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

321282
stoichiometry: 1.0
species: 712201
type: SpeciesReference

322920
stoichiometry: 1.0
species: 711181
type: SpeciesReference

714041
kinetic law: 322800
product: 322788
reactant: 322776
reactant: 322764
fast: false
reversible: true
type: Reaction

321667
stoichiometry: 1.0
species: 711261
type: SpeciesReference

036930
units: 319093
value: 3.24008424E-16
type: LocalParameter

036959
units: 319057
value: 9.0E-15
type: LocalParameter

322546
stoichiometry: 1.0
species: 711781
type: SpeciesReference

323425
local parameters: 037113
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

322558
local parameters: 037068
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

322716
stoichiometry: 1.0
species: 711861
type: SpeciesReference

321847
stoichiometry: 1.0
species: 711341
type: SpeciesReference

712001
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

710761
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

714161
kinetic law: 323088
product: 323076
reactant: 323064
reactant: 323052
fast: false
reversible: true
type: Reaction

322136
stoichiometry: 1.0
species: 711561
type: SpeciesReference

037037
units: 319057
value: 1.224E-17
type: LocalParameter

322740
stoichiometry: 1.0
species: 711781
type: SpeciesReference

712761
kinetic law: 319739
product: 319727
reactant: 319714
reactant: 319701
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true
type: Reaction

319824
stoichiometry: 1.0
species: 711481
type: SpeciesReference

711741
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

320164
local parameters: 036952
local parameters: 036951
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_minus_active_PSD
type: KineticLaw

319701
stoichiometry: 1.0
species: 711421
type: SpeciesReference

711541
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

321570
stoichiometry: 1.0
species: 711261
type: SpeciesReference

712041
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

319240
stoichiometry: 1.0
species: 710921
type: SpeciesReference

712721
kinetic law: 319639
product: 319627
product: 319615
reactant: 319603
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

321642
stoichiometry: 1.0
species: 711301
type: SpeciesReference

320846
stoichiometry: 1.0
species: 710801
type: SpeciesReference

320689
stoichiometry: 1.0
species: 710981
type: SpeciesReference

712021
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661
type: Species

323256
stoichiometry: 1.0
species: 712361
type: SpeciesReference

319069
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

319739
local parameters: 036933
local parameters: 036932
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

320895
stoichiometry: 1.0
species: 710701
type: SpeciesReference

037077
units: 319057
value: 8.0E-18
type: LocalParameter

320225
stoichiometry: 1.0
species: 711141
type: SpeciesReference

713701
kinetic law: 321979
product: 321967
product: 321955
reactant: 321943
fast: false
reversible: false
type: Reaction

319615
stoichiometry: 1.0
species: 710701
type: SpeciesReference

322040
stoichiometry: 1.0
species: 711401
type: SpeciesReference

322148
stoichiometry: 1.0
species: 711541
type: SpeciesReference

712661
kinetic law: 319495
product: 319482
reactant: 319470
reactant: 319458
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

319714
stoichiometry: 2.0
species: 710821
type: SpeciesReference

322594
stoichiometry: 1.0
species: 711841
type: SpeciesReference

712321
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 710641
type: Species

322642
stoichiometry: 1.0
species: 711781
type: SpeciesReference

322728
stoichiometry: 1.0
species: 711521
type: SpeciesReference

712341
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710641
type: Species

321859
stoichiometry: 1.0
species: 711761
type: SpeciesReference

037088
units: 319057
value: 3.06E-17
type: LocalParameter

319812
stoichiometry: 1.0
species: 711661
type: SpeciesReference

320152
stoichiometry: 1.0
species: 711781
type: SpeciesReference

320579
stoichiometry: 1.0
species: 710741
type: SpeciesReference

037078
units: 319057
value: 2.0E-18
type: LocalParameter

321390
local parameters: 037008
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

711081
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321233
stoichiometry: 1.0
species: 711021
type: SpeciesReference

037038
units: 319057
value: 3.06E-18
type: LocalParameter

321654
stoichiometry: 1.0
species: 711241
type: SpeciesReference

321558
stoichiometry: 1.0
species: 711181
type: SpeciesReference

319591
local parameters: 036927
local parameters: 036925
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

320833
stoichiometry: 1.0
species: 710701
type: SpeciesReference

322655
local parameters: 037073
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

710622
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

037048
units: 319057
value: 6.0E-17
type: LocalParameter

321582
local parameters: 037018
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

713061
kinetic law: 320420
product: 320408
reactant: 320396
fast: false
reversible: true
type: Reaction

711001
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 710641
type: Species

711021
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 710641
type: Species

323040
local parameters: 037093
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

319727
stoichiometry: 1.0
species: 711441
type: SpeciesReference

320883
stoichiometry: 1.0
species: 710901
type: SpeciesReference

713041
kinetic law: 320384
product: 320371
reactant: 320358
fast: false
reversible: true
type: Reaction

320237
stoichiometry: 1.0
species: 710821
type: SpeciesReference

319627
stoichiometry: 1.0
species: 711181
type: SpeciesReference

713683
kinetic law: 321931
product: 321919
reactant: 321907
reactant: 321895
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

323244
stoichiometry: 1.0
species: 711501
type: SpeciesReference

714121
kinetic law: 322992
product: 322980
reactant: 322968
reactant: 322956
fast: false
reversible: true
type: Reaction

710821
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 710641
type: Species

713841
kinetic law: 322316
product: 322304
reactant: 322292
reactant: 322280
fast: false
reversible: true
type: Reaction

319800
stoichiometry: 1.0
species: 711521
type: SpeciesReference

320188
stoichiometry: 1.0
species: 711781
type: SpeciesReference

322764
stoichiometry: 1.0
species: 711541
type: SpeciesReference

320567
local parameters: 036969
local parameters: 036968
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

319385
stoichiometry: 1.0
species: 711141
type: SpeciesReference

712881
kinetic law: 320031
product: 320019
product: 320007
reactant: 319995
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

711861
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

711841
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

713461
kinetic law: 321390
product: 321378
product: 321366
reactant: 321354
fast: false
reversible: false
type: Reaction

322112
stoichiometry: 1.0
species: 711561
type: SpeciesReference

712861
kinetic law: 319983
product: 319971
product: 319959
reactant: 319947
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true
type: Reaction

710721
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

711801
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

714101
kinetic law: 322944
product: 322932
product: 322920
reactant: 322908
fast: false
reversible: false
type: Reaction

322668
stoichiometry: 1.0
species: 712101
type: SpeciesReference

713861
kinetic law: 322365
product: 322352
product: 322340
reactant: 322328
fast: false
reversible: false
type: Reaction

319861
stoichiometry: 1.0
species: 711901
type: SpeciesReference

319639
local parameters: 036929
local parameters: 036928
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1
type: KineticLaw

713161
kinetic law: 320665
product: 320653
reactant: 320641
reactant: 320628
fast: false
reversible: true
type: Reaction

322704
local parameters: 037077
local parameters: 037075
notes: k1*CaMKII_minus_thr305_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

323232
local parameters: 037103
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

320273
stoichiometry: 1.0
species: 711481
type: SpeciesReference

711881
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

320871
stoichiometry: 1.0
species: 710801
type: SpeciesReference

713821
kinetic law: 322268
product: 322256
product: 322244
reactant: 322232
fast: false
reversible: false
type: Reaction

321183
stoichiometry: 1.0
species: 712201
type: SpeciesReference

322064
stoichiometry: 1.0
species: 711361
type: SpeciesReference

319105
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

713661
kinetic law: 321883
product: 321871
product: 321859
reactant: 321847
fast: false
reversible: false
type: Reaction

712061
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

320201
stoichiometry: 1.0
species: 711741
type: SpeciesReference

713521
kinetic law: 321534
product: 321522
reactant: 321510
reactant: 321498
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

321594
stoichiometry: 1.0
species: 711221
type: SpeciesReference

713801
kinetic law: 322220
product: 322208
reactant: 322196
reactant: 322184
fast: false
reversible: true
type: Reaction

712081
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

321318
stoichiometry: 1.0
species: 712221
type: SpeciesReference

321245
local parameters: 037002
local parameters: 037000
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

037008
units: 319057
value: 5.4E-16
type: LocalParameter

321546
stoichiometry: 1.0
species: 711281
type: SpeciesReference

712681
kinetic law: 319543
product: 319531
reactant: 319519
reactant: 319507
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

320821
stoichiometry: 1.0
species: 711081
type: SpeciesReference

320176
stoichiometry: 1.0
species: 711721
type: SpeciesReference

321220
stoichiometry: 1.0
species: 712201
type: SpeciesReference

319397
local parameters: 036915
local parameters: 036914
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3
type: KineticLaw

322752
local parameters: 037078
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

714261
kinetic law: 323328
product: 323316
product: 323304
reactant: 323292
fast: false
reversible: false
type: Reaction

711201
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

320761
local parameters: 036977
local parameters: 036975
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

710981
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

714241
kinetic law: 323280
product: 323268
reactant: 323256
reactant: 323244
fast: false
reversible: true
type: Reaction

036938
units: 319142
value: 1.08E-20
type: LocalParameter

036978
units: 319057
value: 2.25E-16
type: LocalParameter

322124
local parameters: 037047
local parameters: 037045
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

320554
stoichiometry: 1.0
species: 710741
type: SpeciesReference

319117
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

320213
local parameters: 036954
local parameters: 036953
notes: kf*PP1_PSD_slash_I1_star_*PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

322052
stoichiometry: 1.0
species: 711701
type: SpeciesReference

320261
local parameters: 036956
local parameters: 036955
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4
type: KineticLaw

710901
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 710641
type: Species

713761
kinetic law: 322124
product: 322112
reactant: 322100
reactant: 322088
fast: false
reversible: true
type: Reaction

323220
stoichiometry: 1.0
species: 711921
type: SpeciesReference

320809
local parameters: 036978
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

319203
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

710921
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321534
local parameters: 037017
local parameters: 037015
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

036939
units: 319057
value: 0.0
type: LocalParameter

321630
local parameters: 037022
local parameters: 037020
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

713561
kinetic law: 321630
product: 321618
reactant: 321606
reactant: 321594
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

036977
units: 319057
value: 9.0E-16
type: LocalParameter

321257
stoichiometry: 1.0
species: 711021
type: SpeciesReference

036987
units: 319057
value: 3.24E-15
type: LocalParameter

319313
stoichiometry: 1.0
species: 711101
type: SpeciesReference

323064
stoichiometry: 1.0
species: 711921
type: SpeciesReference

711101
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 710641
type: Species

713261
kinetic law: 320907
product: 320895
product: 320883
reactant: 320871
fast: false
reversible: false
type: Reaction

319276
stoichiometry: 1.0
species: 710681
type: SpeciesReference

320967
stoichiometry: 1.0
species: 710861
type: SpeciesReference

036997
units: 319057
value: 2.16E-15
type: LocalParameter

320677
stoichiometry: 1.0
species: 710761
type: SpeciesReference

321306
stoichiometry: 1.0
species: 710981
type: SpeciesReference

036919
units: 319057
value: 1.0E-16
type: LocalParameter

319788
local parameters: 036935
local parameters: 036934
notes: kf*CaM_minus_Ca4*CaNAB_minus_Ca4-kb*CaM_Ca_n_minus_CaNAB
type: KineticLaw

323004
stoichiometry: 1.0
species: 711961
type: SpeciesReference

320345
local parameters: 036960
local parameters: 036959
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

711241
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

322980
stoichiometry: 1.0
species: 711961
type: SpeciesReference

713281
kinetic law: 320955
product: 320943
reactant: 320931
reactant: 320919
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

037095
units: 319142
value: 3.420036E-18
type: LocalParameter

711221
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321979
local parameters: 037038
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

036988
units: 319057
value: 8.1E-16
type: LocalParameter

320358
stoichiometry: 1.0
species: 712161
type: SpeciesReference

037005
units: 319142
value: 7.714278E-18
type: LocalParameter

319947
stoichiometry: 1.0
species: 711521
type: SpeciesReference

321402
stoichiometry: 1.0
species: 710921
type: SpeciesReference

712781
kinetic law: 319788
product: 319776
reactant: 319764
reactant: 319751
fast: false
reversible: true
type: Reaction

320907
local parameters: 036983
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

319689
local parameters: 036931
local parameters: 036930
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*CaNAB_minus_Ca4
type: KineticLaw

036918
units: 319142
value: 3.6E-17
type: LocalParameter

036998
units: 319057
value: 5.4E-16
type: LocalParameter

321919
stoichiometry: 1.0
species: 711381
type: SpeciesReference

321474
stoichiometry: 1.0
species: 712221
type: SpeciesReference

320444
stoichiometry: 1.0
species: 710701
type: SpeciesReference

711281
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 710641
type: Species

321135
stoichiometry: 1.0
species: 711001
type: SpeciesReference

711261
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 710641
type: Species

711421
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 710641
type: Species

323316
stoichiometry: 1.0
species: 712361
type: SpeciesReference

320043
stoichiometry: 1.0
species: 711501
type: SpeciesReference

321354
stoichiometry: 1.0
species: 711041
type: SpeciesReference

323280
local parameters: 037107
local parameters: 037105
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

319373
stoichiometry: 1.0
species: 710821
type: SpeciesReference

037025
units: 319142
value: 6.4584E-18
type: LocalParameter

319887
local parameters: 036939
local parameters: 036938
notes: kf*CaMKII_slash_CaMKII_minus_CaM*NMDAR-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

322776
stoichiometry: 1.0
species: 711781
type: SpeciesReference

037080
units: 319142
value: 4.99998E-18
type: LocalParameter

322425
stoichiometry: 1.0
species: 711801
type: SpeciesReference

322389
stoichiometry: 1.0
species: 711781
type: SpeciesReference

037015
units: 319142
value: 5.81256E-17
type: LocalParameter

036985
units: 319142
value: 5.399946E-16
type: LocalParameter

711941
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

320665
local parameters: 036972
local parameters: 036971
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

320371
stoichiometry: 1.0
species: 711681
type: SpeciesReference

712241
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661
type: Species

713121
kinetic law: 320567
product: 320554
reactant: 320542
reactant: 320530
fast: false
reversible: true
type: Reaction

319301
local parameters: 036911
local parameters: 036909
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

710681
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

323052
stoichiometry: 1.0
species: 711721
type: SpeciesReference

319288
stoichiometry: 1.0
species: 710941
type: SpeciesReference

320979
stoichiometry: 1.0
species: 711201
type: SpeciesReference

322438
stoichiometry: 1.0
species: 711481
type: SpeciesReference

713141
kinetic law: 320616
product: 320604
product: 320592
reactant: 320579
fast: false
reversible: false
type: Reaction

323100
stoichiometry: 1.0
species: 711981
type: SpeciesReference

319971
stoichiometry: 1.0
species: 711901
type: SpeciesReference

323016
stoichiometry: 1.0
species: 711241
type: SpeciesReference

037083
units: 319057
value: 2.0E-18
type: LocalParameter

711921
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

712701
kinetic law: 319591
product: 319579
reactant: 319567
reactant: 319555
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

320333
stoichiometry: 1.0
species: 710821
type: SpeciesReference

319129
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

037012
units: 319057
value: 1.8E-16
type: LocalParameter

037093
units: 319057
value: 3.06E-17
type: LocalParameter

319874
stoichiometry: 1.0
species: 711481
type: SpeciesReference

712261
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

712601
kinetic law: 319349
product: 319337
reactant: 319325
reactant: 319313
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

319677
stoichiometry: 1.0
species: 711361
type: SpeciesReference

320919
stoichiometry: 1.0
species: 711181
type: SpeciesReference

037007
units: 319057
value: 2.16E-15
type: LocalParameter

711161
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321462
stoichiometry: 1.0
species: 710941
type: SpeciesReference

711821
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

321907
stoichiometry: 1.0
species: 711361
type: SpeciesReference

321147
local parameters: 036997
local parameters: 036995
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

320456
stoichiometry: 1.0
species: 710721
type: SpeciesReference

321414
stoichiometry: 1.0
species: 712221
type: SpeciesReference

712641
kinetic law: 319446
product: 319434
reactant: 319422
reactant: 319410
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

320384
local parameters: 036962
local parameters: 036961
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

711621
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

319959
stoichiometry: 1.0
species: 710901
type: SpeciesReference

714141
kinetic law: 323040
product: 323028
product: 323016
reactant: 323004
fast: false
reversible: false
type: Reaction

713881
kinetic law: 322413
product: 322401
reactant: 322389
reactant: 322377
fast: false
reversible: true
type: Reaction

037082
units: 319057
value: 8.0E-18
type: LocalParameter

321366
stoichiometry: 1.0
species: 710961
type: SpeciesReference

037092
units: 319057
value: 1.224E-16
type: LocalParameter

037013
units: 319057
value: 4.5E-17
type: LocalParameter

037027
units: 319057
value: 7.50006E-16
type: LocalParameter

322377
stoichiometry: 1.0
species: 711461
type: SpeciesReference

320055
stoichiometry: 1.0
species: 711661
type: SpeciesReference

711181
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 710641
type: Species

319361
stoichiometry: 1.0
species: 711161
type: SpeciesReference

710641
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

711901
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 710661
type: Species

323328
local parameters: 037108
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

322788
stoichiometry: 1.0
species: 711881
type: SpeciesReference

713241
kinetic law: 320859
product: 320846
reactant: 320833
reactant: 320821
fast: false
reversible: true
type: Reaction

036915
units: 319057
value: 9.0E-16
type: LocalParameter

712981
kinetic law: 320261
product: 320249
reactant: 320237
reactant: 320225
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

037000
units: 319142
value: 9.91197E-19
type: LocalParameter

037085
units: 319142
value: 3.0779838E-17
type: LocalParameter

319603
stoichiometry: 1.0
species: 711241
type: SpeciesReference

322680
stoichiometry: 1.0
species: 711781
type: SpeciesReference

322232
stoichiometry: 1.0
species: 711581
type: SpeciesReference

323112
stoichiometry: 1.0
species: 711701
type: SpeciesReference

036929
units: 319142
value: 0.0
type: LocalParameter

036993
units: 319057
value: 8.1E-16
type: LocalParameter

323028
stoichiometry: 1.0
species: 711921
type: SpeciesReference

036983
units: 319057
value: 2.25E-16
type: LocalParameter

036909
units: 319142
value: 9.001692E-14
type: LocalParameter

319252
local parameters: 036908
local parameters: 036907
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

319337
stoichiometry: 1.0
species: 711161
type: SpeciesReference

320309
local parameters: 036958
local parameters: 036957
notes: kf*CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_minus_PSD
type: KineticLaw

712561
kinetic law: 319252
product: 319240
reactant: 319227
reactant: 319215
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

319983
local parameters: 036943
local parameters: 036942
notes: kf*CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*NMDAR
type: KineticLaw

320530
stoichiometry: 1.0
species: 710981
type: SpeciesReference

037028
units: 319057
value: 1.8E-16
type: LocalParameter

323088
local parameters: 037097
local parameters: 037095
notes: k1*PP1_PSD_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

037018
units: 319057
value: 1.8E-16
type: LocalParameter

319664
stoichiometry: 1.0
species: 711441
type: SpeciesReference

320653
stoichiometry: 1.0
species: 710761
type: SpeciesReference

713221
kinetic law: 320809
product: 320797
product: 320785
reactant: 320773
fast: false
reversible: false
type: Reaction

713541
kinetic law: 321582
product: 321570
product: 321558
reactant: 321546
fast: false
reversible: false
type: Reaction

711301
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 710641
type: Species

036914
units: 319142
value: 3.2400162E-16
type: LocalParameter

712901
kinetic law: 320079
product: 320067
reactant: 320055
reactant: 320043
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

037098
units: 319057
value: 3.06E-17
type: LocalParameter

320943
stoichiometry: 1.0
species: 710861
type: SpeciesReference

320859
local parameters: 036982
local parameters: 036980
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

713201
kinetic law: 320761
product: 320749
reactant: 320737
reactant: 320725
fast: false
reversible: true
type: Reaction

036928
units: 319057
value: 9.0E-17
type: LocalParameter

321378
stoichiometry: 1.0
species: 712221
type: SpeciesReference

320396
stoichiometry: 1.0
species: 712181
type: SpeciesReference

321426
stoichiometry: 1.0
species: 711061
type: SpeciesReference

036908
units: 319057
value: 4.5E-16
type: LocalParameter

321785
local parameters: 037028
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

320067
stoichiometry: 1.0
species: 711461
type: SpeciesReference

712921
kinetic law: 320116
product: 320104
reactant: 320091
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

319923
stoichiometry: 1.0
species: 711461
type: SpeciesReference

321450
stoichiometry: 1.0
species: 711061
type: SpeciesReference

320420
local parameters: 036964
local parameters: 036963
notes: kf*basal_CaMKII_PSD_control-kb*basal_CaMKII_PSD
type: KineticLaw

321159
stoichiometry: 1.0
species: 711001
type: SpeciesReference

319911
stoichiometry: 1.0
species: 711901
type: SpeciesReference

036913
units: 319057
value: 6.48E-15
type: LocalParameter

711321
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 710641
type: Species

322692
stoichiometry: 1.0
species: 711861
type: SpeciesReference

037087
units: 319057
value: 1.224E-16
type: LocalParameter

711961
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

323124
stoichiometry: 1.0
species: 711921
type: SpeciesReference

321835
local parameters: 037032
local parameters: 037030
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

322220
local parameters: 037052
local parameters: 037050
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

713741
kinetic law: 322076
product: 322064
product: 322052
reactant: 322040
fast: false
reversible: false
type: Reaction

036917
units: 319057
value: 7.2E-16
type: LocalParameter

037002
units: 319057
value: 1.8E-16
type: LocalParameter

036995
units: 319142
value: 1.1894364E-17
type: LocalParameter

320249
stoichiometry: 1.0
species: 710681
type: SpeciesReference

036927
units: 319057
value: 9.0E-18
type: LocalParameter

319652
stoichiometry: 2.0
species: 710821
type: SpeciesReference

713981
kinetic law: 322655
product: 322642
product: 322630
reactant: 322618
fast: false
reversible: false
type: Reaction

037097
units: 319057
value: 1.224E-16
type: LocalParameter

320641
stoichiometry: 1.0
species: 710701
type: SpeciesReference

713961
kinetic law: 322606
product: 322594
reactant: 322582
reactant: 322570
fast: false
reversible: true
type: Reaction

036907
units: 319142
value: 4.4999712E-15
type: LocalParameter

321772
stoichiometry: 1.0
species: 711261
type: SpeciesReference

319325
stoichiometry: 2.0
species: 710821
type: SpeciesReference

319166
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

319995
stoichiometry: 1.0
species: 712101
type: SpeciesReference

323076
stoichiometry: 1.0
species: 711981
type: SpeciesReference

320542
stoichiometry: 1.0
species: 710701
type: SpeciesReference

319264
stoichiometry: 1.0
species: 710981
type: SpeciesReference

711981
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321196
local parameters: 036998
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

713921
kinetic law: 322510
product: 322498
reactant: 322486
reactant: 322474
fast: false
reversible: true
type: Reaction

320955
local parameters: 036987
local parameters: 036985
notes: k1*PP1_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

037003
units: 319057
value: 4.5E-17
type: LocalParameter

036982
units: 319057
value: 9.0E-16
type: LocalParameter

036916
units: 319093
value: 7.2E-16
type: LocalParameter

713901
kinetic law: 322462
product: 322450
product: 322438
reactant: 322425
fast: false
reversible: false
type: Reaction

320031
local parameters: 036945
local parameters: 036944
notes: kf*CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*NMDAR
type: KineticLaw

323292
stoichiometry: 1.0
species: 712041
type: SpeciesReference

319899
stoichiometry: 1.0
species: 710941
type: SpeciesReference

714321
kinetic law: 323475
product: 323463
reactant: 323451
reactant: 323438
fast: false
reversible: true
type: Reaction

319935
local parameters: 036941
local parameters: 036940
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*NMDAR-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

710741
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

320432
stoichiometry: 1.0
species: 710941
type: SpeciesReference

320079
local parameters: 036947
local parameters: 036946
notes: kf*CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

319179
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

714341
kinetic law: 323523
product: 323511
product: 323499
reactant: 323487
fast: false
reversible: false
type: Reaction

713941
kinetic law: 322558
product: 322546
product: 322534
reactant: 322522
fast: false
reversible: false
type: Reaction

321438
local parameters: 037012
local parameters: 037010
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

037017
units: 319057
value: 7.50006E-16
type: LocalParameter

322630
stoichiometry: 1.0
species: 712101
type: SpeciesReference

321931
local parameters: 037037
local parameters: 037035
notes: k1*PP1_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

319555
stoichiometry: 1.0
species: 711201
type: SpeciesReference

036940
units: 319142
value: 1.08E-20
type: LocalParameter

711041
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 710641
type: Species

036950
units: 319057
value: 5.4E-15
type: LocalParameter

319446
local parameters: 036917
local parameters: 036916
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

037060
units: 319142
value: 4.99998E-18
type: LocalParameter

711441
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

713081
kinetic law: 320468
product: 320456
reactant: 320444
reactant: 320432
fast: false
reversible: true
type: Reaction

320749
stoichiometry: 1.0
species: 710781
type: SpeciesReference

036960
units: 319057
value: 9.0E-15
type: LocalParameter

037117
units: 319057
value: 8.0E-17
type: LocalParameter

321039
stoichiometry: 1.0
species: 710881
type: SpeciesReference

036925
units: 319142
value: 4.4998254E-14
type: LocalParameter

320408
stoichiometry: 1.0
species: 712021
type: SpeciesReference

322968
stoichiometry: 1.0
species: 711921
type: SpeciesReference

711061
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 710641
type: Species

037107
units: 319057
value: 2.4E-16
type: LocalParameter

036970
units: 319057
value: 2.25E-16
type: LocalParameter

319154
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

321991
stoichiometry: 1.0
species: 711721
type: SpeciesReference

712361
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

711681
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 710661
type: Species

713001
kinetic law: 320309
product: 320297
product: 320285
reactant: 320273
fast: false
reversible: true
type: Reaction

036923
units: 319057
value: 1.0E-16
type: LocalParameter

321618
stoichiometry: 1.0
species: 711301
type: SpeciesReference

711581
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

323196
stoichiometry: 1.0
species: 712001
type: SpeciesReference

037118
units: 319057
value: 2.0E-17
type: LocalParameter

MODEL9086926384
species: 710981
species: 710921
reaction: 713701
reaction: 712861
reaction: 713821
species: 710721
reaction: 714041
reaction: 713981
species: 710881
species: 711921
name: Hayer2005_CaMKII_noPKA_model3
reaction: 713801
species: 712221
species: 710741
rule: 712521
reaction: 713281
species: 711061
reaction: 713961
reaction: 713021
species: 711421
reaction: 713061
volume units: 679943
species: 710941
species: 711201
reaction: 713261
reaction: 713741
species: 711081
reaction: 712801
reaction: 713001
reaction: 713581
reaction: 713041
reaction: 713521
compartment: 710661
species: 710841
reaction: 713661
species: 712301
species: 711861
reaction: 712901
compartment: 710641
species: 710701
rule: 712401
reaction: 712621
species: 711641
species: 710861
reaction: 712661
species: 711721
species: 711361
species: 711501
reaction: 713081
species: 711041
species: 711141
species: 712121
species: 711401
species: 711681
reaction: 713721
reaction: 714281
reaction: 713201
reaction: 714061
time units: 131570
reaction: 712981
species: 711821
area units: area
species: 710821
species: 711481
curated: false
species: 712081
reaction: 713241
species: 711841
species: 712321
rule: 712541
species: 712001
species: 711621
reaction: 713641
reaction: 713221
reaction: 713421
species: 710781
reaction: 712841
reaction: 712761
type: SBMLModel
reaction: 712821

713021
kinetic law: 320345
product: 320333
reactant: 320321
fast: false
reversible: true
type: Reaction

322570
stoichiometry: 1.0
species: 711541
type: SpeciesReference

321051
local parameters: 036992
local parameters: 036990
notes: k1*PP1_PSD_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

322340
stoichiometry: 1.0
species: 711501
type: SpeciesReference

036990
units: 319142
value: 5.99994E-17
type: LocalParameter

323511
stoichiometry: 1.0
species: 712361
type: SpeciesReference

321823
stoichiometry: 1.0
species: 711341
type: SpeciesReference

323136
local parameters: 037098
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

322256
stoichiometry: 1.0
species: 712241
type: SpeciesReference

036980
units: 319142
value: 2.2062942E-16
type: LocalParameter

037075
units: 319142
value: 4.99998E-18
type: LocalParameter

037108
units: 319057
value: 6.0E-17
type: LocalParameter

711401
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

323499
stoichiometry: 1.0
species: 711501
type: SpeciesReference

037072
units: 319057
value: 8.0E-18
type: LocalParameter

036912
units: 319093
value: 6.47990604E-15
type: LocalParameter

319434
stoichiometry: 1.0
species: 711621
type: SpeciesReference

713601
kinetic law: 321733
product: 321720
reactant: 321706
reactant: 321693
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

712301
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661
type: Species

319751
stoichiometry: 1.0
species: 710681
type: SpeciesReference

710861
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

321943
stoichiometry: 1.0
species: 711381
type: SpeciesReference

319543
local parameters: 036923
local parameters: 036921
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD
type: KineticLaw

711701
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 710661
type: Species

036952
units: 319142
value: 0.0
type: LocalParameter

037062
units: 319057
value: 8.0E-18
type: LocalParameter

320931
stoichiometry: 1.0
species: 710841
type: SpeciesReference

711501
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

322956
stoichiometry: 1.0
species: 711221
type: SpeciesReference

711381
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

036972
units: 319057
value: 9.0E-16
type: LocalParameter

319495
local parameters: 036919
local parameters: 036918
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD
type: KineticLaw

711601
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661
type: Species

712621
kinetic law: 319397
product: 319385
reactant: 319373
reactant: 319361
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

710881
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

037105
units: 319142
value: 9.375E-19
type: LocalParameter

321027
stoichiometry: 1.0
species: 710841
type: SpeciesReference

321693
stoichiometry: 1.0
species: 711721
type: SpeciesReference

711641
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00254583333333333
initial amount: NaN
in compartment: 710661
type: Species

037073
units: 319057
value: 2.0E-18
type: LocalParameter

036911
units: 319057
value: 9.0E-18
type: LocalParameter

323184
local parameters: 037102
local parameters: 037100
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

711781
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 710661
type: Species

320991
stoichiometry: 1.0
species: 710841
type: SpeciesReference

036921
units: 319142
value: 4.65012E-18
type: LocalParameter

319349
local parameters: 036913
local parameters: 036912
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2
type: KineticLaw

036951
units: 319057
value: 1.0E-17
type: LocalParameter

322244
stoichiometry: 1.0
species: 711461
type: SpeciesReference

323523
local parameters: 037118
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

036992
units: 319057
value: 3.24E-15
type: LocalParameter

710661
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

321811
stoichiometry: 1.0
species: 711261
type: SpeciesReference

037063
units: 319057
value: 2.0E-18
type: LocalParameter

323487
stoichiometry: 1.0
species: 712081
type: SpeciesReference

036971
units: 319142
value: 2.2062942E-16
type: LocalParameter

323340
stoichiometry: 1.0
species: 711481
type: SpeciesReference

322582
stoichiometry: 1.0
species: 711781
type: SpeciesReference

711361
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

322304
stoichiometry: 1.0
species: 711601
type: SpeciesReference

711341
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 710641
type: Species

323148
stoichiometry: 1.0
species: 711741
type: SpeciesReference

322365
local parameters: 037058
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

321015
stoichiometry: 1.0
species: 711701
type: SpeciesReference

037010
units: 319142
value: 6.428808E-19
type: LocalParameter

321330
stoichiometry: 1.0
species: 711041
type: SpeciesReference

320725
stoichiometry: 1.0
species: 710961
type: SpeciesReference

322606
local parameters: 037072
local parameters: 037070
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

320128
stoichiometry: 1.0
species: 711761
type: SpeciesReference

323208
stoichiometry: 1.0
species: 711761
type: SpeciesReference

319531
stoichiometry: 1.0
species: 711661
type: SpeciesReference

321883
local parameters: 037033
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

037020
units: 319142
value: 5.81256E-17
type: LocalParameter

037070
units: 319142
value: 4.99998E-18
type: LocalParameter

321759
stoichiometry: 1.0
species: 711701
type: SpeciesReference

710961
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

322401
stoichiometry: 1.0
species: 711801
type: SpeciesReference

714201
kinetic law: 323184
product: 323172
reactant: 323160
reactant: 323148
fast: false
reversible: true
type: Reaction

321498
stoichiometry: 1.0
species: 711201
type: SpeciesReference

321955
stoichiometry: 1.0
species: 711181
type: SpeciesReference

710941
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641
type: Species

037050
units: 319142
value: 4.99998E-20
type: LocalParameter

714221
kinetic law: 323232
product: 323220
product: 323208
reactant: 323196
fast: false
reversible: false
type: Reaction

036964
units: 319057
value: 1.0E-17
type: LocalParameter

320468
local parameters: 036966
local parameters: 036965
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

319081
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

320321
stoichiometry: 1.0
species: 712141
type: SpeciesReference

037090
units: 319142
value: 3.0779838E-17
type: LocalParameter

321075
stoichiometry: 1.0
species: 711721
type: SpeciesReference

319764
stoichiometry: 1.0
species: 711361
type: SpeciesReference

322316
local parameters: 037057
local parameters: 037055
notes: k1*CaMKII_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

321798
stoichiometry: 1.0
species: 711741
type: SpeciesReference

713621
kinetic law: 321785
product: 321772
product: 321759
reactant: 321746
fast: false
reversible: false
type: Reaction

714281
kinetic law: 323376
product: 323364
reactant: 323352
reactant: 323340
fast: false
reversible: true
type: Reaction

712581
kinetic law: 319301
product: 319288
reactant: 319276
reactant: 319264
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

319482
stoichiometry: 1.0
species: 711641
type: SpeciesReference

321706
stoichiometry: 1.0
species: 711261
type: SpeciesReference

322292
stoichiometry: 1.0
species: 712241
type: SpeciesReference

036963
units: 319057
value: 1.0E-17
type: LocalParameter

712181
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661
type: Species

322812
stoichiometry: 1.0
species: 711881
type: SpeciesReference

036973
units: 319057
value: 2.25E-16
type: LocalParameter

320592
stoichiometry: 1.0
species: 710901
type: SpeciesReference

320116
local parameters: 036950
local parameters: 036948
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4
type: KineticLaw

321208
stoichiometry: 1.0
species: 710921
type: SpeciesReference

322618
stoichiometry: 1.0
species: 711841
type: SpeciesReference

322413
local parameters: 037062
local parameters: 037060
notes: k1*CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

321895
stoichiometry: 1.0
species: 711201
type: SpeciesReference

323304
stoichiometry: 1.0
species: 711541
type: SpeciesReference

321003
local parameters: 036988
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

321342
local parameters: 037007
local parameters: 037005
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

320737
stoichiometry: 1.0
species: 710701
type: SpeciesReference

037022
units: 319057
value: 7.50006E-16
type: LocalParameter

713321
kinetic law: 321051
product: 321039
reactant: 321027
reactant: 321015
fast: false
reversible: true
type: Reaction

319458
stoichiometry: 1.0
species: 711621
type: SpeciesReference

036962
units: 319057
value: 1.0E-15
type: LocalParameter

321486
local parameters: 037013
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

713301
kinetic law: 321003
product: 320991
product: 320979
reactant: 320967
fast: false
reversible: false
type: Reaction

321967
stoichiometry: 1.0
species: 711361
type: SpeciesReference

319470
stoichiometry: 1.0
species: 711681
type: SpeciesReference

712821
kinetic law: 319887
product: 319874
reactant: 319861
reactant: 319848
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true
type: Reaction

713361
kinetic law: 321147
product: 321135
reactant: 321123
reactant: 321111
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

322992
local parameters: 037092
local parameters: 037090
notes: k1*PP1_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

321063
stoichiometry: 1.0
species: 710881
type: SpeciesReference

319776
stoichiometry: 1.0
species: 711921
type: SpeciesReference

322352
stoichiometry: 1.0
species: 712241
type: SpeciesReference

322328
stoichiometry: 1.0
species: 711601
type: SpeciesReference

322268
local parameters: 037053
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

037023
units: 319057
value: 1.8E-16
type: LocalParameter

322800
local parameters: 037082
local parameters: 037080
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

322027
local parameters: 037042
local parameters: 037040
notes: k1*PP1_PSD_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

036961
units: 319057
value: 1.0E-15
type: LocalParameter

713341
kinetic law: 321099
product: 321087
product: 321075
reactant: 321063
fast: false
reversible: false
type: Reaction

712841
kinetic law: 319935
product: 319923
reactant: 319911
reactant: 319899
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

322908
stoichiometry: 1.0
species: 711941
type: SpeciesReference

036975
units: 319142
value: 2.2062942E-16
type: LocalParameter

321680
local parameters: 037023
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

713421
kinetic law: 321294
product: 321282
product: 321270
reactant: 321257
fast: false
reversible: false
type: Reaction