208207
units: 257775
value: 3.5E-18
type: LocalParameter

402420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207743
units: 257775
value: 7.2E-16
type: LocalParameter

269978
stoichiometry: 1.0
species: 403720
type: SpeciesReference

403900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258230
stoichiometry: 1.0
species: 405880
type: SpeciesReference

407220
kinetic law: 258894
product: 258882
reactant: 258870
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

407340
kinetic law: 259429
product: 259417
product: 259405
reactant: 259393
fast: false
reversible: true
type: Reaction

258809
local parameters: 207388
local parameters: 207386
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD
type: KineticLaw

258991
local parameters: 207400
local parameters: 207398
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_slash_PP1_minus_active*PP1_slash_I1
type: KineticLaw

259188
local parameters: 207412
local parameters: 207410
notes: kf*PKA_slash_R2C2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP
type: KineticLaw

259103
stoichiometry: 1.0
species: 401780
type: SpeciesReference

274615
local parameters: 208226
local parameters: 208224
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

272697
stoichiometry: 1.0
species: 404580
type: SpeciesReference

269411
stoichiometry: 1.0
species: 405680
type: SpeciesReference

207958
units: 257775
value: 2.16E-15
type: LocalParameter

261555
stoichiometry: 1.0
species: 405660
type: SpeciesReference

264097
stoichiometry: 1.0
species: 402200
type: SpeciesReference

262187
stoichiometry: 1.0
species: 406100
type: SpeciesReference

208206
units: 257775
value: 1.4E-17
type: LocalParameter

271357
stoichiometry: 1.0
species: 404280
type: SpeciesReference

258955
stoichiometry: 1.0
species: 401860
type: SpeciesReference

275350
stoichiometry: 1.0
species: 405040
type: SpeciesReference

208199
units: 257862
value: 8.7498E-18
type: LocalParameter

265028
local parameters: 207728
local parameters: 207726
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

411939
kinetic law: 270982
product: 270970
product: 270957
reactant: 270945
fast: false
reversible: false
type: Reaction

270389
stoichiometry: 1.0
species: 403180
type: SpeciesReference

208247
units: 257775
value: 3.15E-17
type: LocalParameter

412679
kinetic law: 272782
product: 272770
reactant: 272757
reactant: 272745
fast: false
reversible: true
type: Reaction

263588
stoichiometry: 1.0
species: 402160
type: SpeciesReference

275206
local parameters: 208256
local parameters: 208254
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

261336
local parameters: 207539
local parameters: 207537
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

273322
stoichiometry: 1.0
species: 405800
type: SpeciesReference

407260
kinetic law: 259040
product: 259028
reactant: 259016
reactant: 259004
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

207424
units: 257862
value: 1.6199838E-15
type: LocalParameter

208044
units: 257775
value: 6.003E-16
type: LocalParameter

273927
stoichiometry: 1.0
species: 404840
type: SpeciesReference

259756
stoichiometry: 1.0
species: 404280
type: SpeciesReference

266842
stoichiometry: 1.0
species: 402200
type: SpeciesReference

266781
stoichiometry: 1.0
species: 402860
type: SpeciesReference

401240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 400700
type: Species

208196
units: 257775
value: 1.4E-17
type: LocalParameter

208209
units: 257862
value: 8.7498E-18
type: LocalParameter

258096
stoichiometry: 1.0
species: 400760
type: SpeciesReference

269362
stoichiometry: 1.0
species: 403180
type: SpeciesReference

260874
stoichiometry: 1.0
species: 401080
type: SpeciesReference

403500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208246
units: 257775
value: 1.26E-16
type: LocalParameter

261020
stoichiometry: 1.0
species: 406100
type: SpeciesReference

403260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

267336
stoichiometry: 1.0
species: 402980
type: SpeciesReference

263600
stoichiometry: 1.0
species: 401800
type: SpeciesReference

208045
units: 257775
value: 1.5003E-16
type: LocalParameter

268706
local parameters: 207918
local parameters: 207916
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

207490
units: 257775
value: 2.16E-15
type: LocalParameter

266310
stoichiometry: 1.0
species: 405600
type: SpeciesReference

267621
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274252
stoichiometry: 1.0
species: 405660
type: SpeciesReference

262932
stoichiometry: 1.0
species: 401880
type: SpeciesReference

207425
units: 257775
value: 5.4E-15
type: LocalParameter

269822
local parameters: 207974
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

207746
units: 257862
value: 1.8106416E-16
type: LocalParameter

265427
stoichiometry: 1.0
species: 402560
type: SpeciesReference

207744
units: 257775
value: 1.8E-16
type: LocalParameter

208197
units: 257775
value: 3.5E-18
type: LocalParameter

274325
local parameters: 208211
local parameters: 208209
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

207427
units: 257862
value: 1.6199838E-15
type: LocalParameter

262332
stoichiometry: 1.0
species: 405620
type: SpeciesReference

263418
stoichiometry: 1.0
species: 401980
type: SpeciesReference

272998
stoichiometry: 1.0
species: 405660
type: SpeciesReference

265366
local parameters: 207744
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

413319
kinetic law: 274325
product: 274313
reactant: 274301
reactant: 274288
fast: false
reversible: true
type: Reaction

270668
stoichiometry: 1.0
species: 405740
type: SpeciesReference

207530
units: 257775
value: 5.0E-18
type: LocalParameter

403220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270111
local parameters: 207989
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

272818
stoichiometry: 1.0
species: 404280
type: SpeciesReference

408339
kinetic law: 262066
product: 262054
product: 262042
reactant: 262030
fast: false
reversible: false
type: Reaction

401200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700
type: Species

404860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207959
units: 257775
value: 5.4E-16
type: LocalParameter

259489
stoichiometry: 1.0
species: 401780
type: SpeciesReference

207451
units: 257775
value: 1.0E-18
type: LocalParameter

207848
units: 257775
value: 2.403E-16
type: LocalParameter

275242
stoichiometry: 1.0
species: 405040
type: SpeciesReference

409279
kinetic law: 264450
product: 264437
reactant: 264425
reactant: 264413
fast: false
reversible: true
type: Reaction

268405
stoichiometry: 1.0
species: 403400
type: SpeciesReference

MODEL9086207764
reaction: 409199
reaction: 412919
reaction: 407220
reaction: 410359
reaction: 410319
reaction: 410159
reaction: 408779
species: 401780
reaction: 409499
species: 405500
species: 404660
reaction: 410079
species: 403620
species: 404120
reaction: 407379
reaction: 409519
reaction: 410499
species: 406280
species: 402280
species: 403840
reaction: 411859
species: 403120
reaction: 411899
reaction: 411139
species: 405900
reaction: 413279
species: 401900
reaction: 411699
species: 404140
reaction: 409859
reaction: 412299
reaction: 407739
reaction: 408099
reaction: 409919
reaction: 412599
species: 404420
reaction: 408479
reaction: 409679
species: 403780
species: 400740
species: 403700
reaction: 413639
reaction: 408399
reaction: 407559
species: 405620
species: 406140
species: 405840
reaction: 407899
species: 405320
reaction: 408879
species: 401320
reaction: 411299
reaction: 411919
reaction: 407240
species: 405640
reaction: 409299
reaction: 410719
species: 401540
reaction: 410179
species: 404580
reaction: 408799
reaction: 407200
species: 405340
reaction: 408599
reaction: 410519
species: 401340
reaction: 410559
species: 405480
species: 401480
reaction: 407399
species: 405000
species: 401000
reaction: 410859
species: 402120
species: 405280
reaction: 410899
reaction: 412399
species: 401280
species: 404900
species: 400900

271079
local parameters: 208040
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

264728
stoichiometry: 1.0
species: 402420
type: SpeciesReference

208194
units: 257862
value: 8.7498E-18
type: LocalParameter

265281
stoichiometry: 1.0
species: 405340
type: SpeciesReference

403880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

403040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

257988
stoichiometry: 1.0
species: 400840
type: SpeciesReference

271610
local parameters: 208069
local parameters: 208067
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

268104
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207748
units: 257775
value: 7.2E-16
type: LocalParameter

257835
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

207347
units: 257862
value: 1.08E-20
type: LocalParameter

410519
kinetic law: 267444
product: 267432
reactant: 267420
reactant: 267408
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true
type: Reaction

263697
stoichiometry: 1.0
species: 404200
type: SpeciesReference

270002
stoichiometry: 1.0
species: 403180
type: SpeciesReference

260168
local parameters: 207475
local parameters: 207473
notes: kf*AMPAR_slash_A845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_
type: KineticLaw

410479
kinetic law: 267348
product: 267336
reactant: 267324
reactant: 267312
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

407659
kinetic law: 260365
product: 260353
reactant: 260340
reactant: 260328
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

208047
units: 257862
value: 1.1339838E-16
type: LocalParameter

272612
stoichiometry: 1.0
species: 405640
type: SpeciesReference

207809
units: 257775
value: 1.8E-16
type: LocalParameter

260655
local parameters: 207505
local parameters: 207503
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

267732
stoichiometry: 1.0
species: 403260
type: SpeciesReference

272540
local parameters: 208115
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

207849
units: 257775
value: 6.03E-17
type: LocalParameter

262078
stoichiometry: 1.0
species: 405760
type: SpeciesReference

207452
units: 257775
value: 8.0E-21
type: LocalParameter

207532
units: 257862
value: 2.77776E-19
type: LocalParameter

257875
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

274651
stoichiometry: 1.0
species: 404280
type: SpeciesReference

272201
stoichiometry: 1.0
species: 404480
type: SpeciesReference

410439
kinetic law: 267252
product: 267240
reactant: 267227
reactant: 267215
fast: false
reversible: true
type: Reaction

268441
stoichiometry: 1.0
species: 405380
type: SpeciesReference

260353
stoichiometry: 1.0
species: 400860
type: SpeciesReference

270909
stoichiometry: 1.0
species: 403980
type: SpeciesReference

274591
stoichiometry: 1.0
species: 404280
type: SpeciesReference

274723
stoichiometry: 1.0
species: 405000
type: SpeciesReference

401980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 400680
type: Species

207346
units: 257775
value: 0.0
type: LocalParameter

257763
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

258882
stoichiometry: 1.0
species: 401780
type: SpeciesReference

258918
stoichiometry: 1.0
species: 401980
type: SpeciesReference

268116
stoichiometry: 1.0
species: 403340
type: SpeciesReference

270086
stoichiometry: 1.0
species: 405780
type: SpeciesReference

260715
stoichiometry: 1.0
species: 401040
type: SpeciesReference

262812
stoichiometry: 1.0
species: 401920
type: SpeciesReference

260728
stoichiometry: 1.0
species: 406060
type: SpeciesReference

403840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207808
units: 257775
value: 7.2E-16
type: LocalParameter

207491
units: 257775
value: 5.4E-16
type: LocalParameter

407159
kinetic law: 258676
product: 258664
reactant: 258652
reactant: 258640
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

259927
local parameters: 207460
local parameters: 207458
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*AMPAR_memb_slash_Anchor
type: KineticLaw

207535
units: 257775
value: 5.0E-18
type: LocalParameter

259684
local parameters: 207445
local parameters: 207443
notes: kf*AC_slash_cAMP-kb*AC_slash_cAMP_in_dend
type: KineticLaw

412259
kinetic law: 271756
product: 271744
product: 271732
reactant: 271719
fast: false
reversible: false
type: Reaction

412319
kinetic law: 271900
product: 271888
reactant: 271876
reactant: 271864
fast: false
reversible: true
type: Reaction

272068
stoichiometry: 1.0
species: 404280
type: SpeciesReference

410559
kinetic law: 267542
product: 267530
reactant: 267518
reactant: 267505
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

258169
local parameters: 207346
local parameters: 207344
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

413559
kinetic law: 274905
product: 274893
reactant: 274881
reactant: 274868
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

208192
units: 257775
value: 3.5E-18
type: LocalParameter

407699
kinetic law: 260461
product: 260449
reactant: 260437
reactant: 260425
fast: false
reversible: true
type: Reaction

402820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

262692
stoichiometry: 1.0
species: 401900
type: SpeciesReference

207421
units: 257775
value: 2.925E-15
type: LocalParameter

269520
stoichiometry: 1.0
species: 403180
type: SpeciesReference

271683
stoichiometry: 1.0
species: 404280
type: SpeciesReference

273058
stoichiometry: 1.0
species: 404660
type: SpeciesReference

208049
units: 257775
value: 3.6E-15
type: LocalParameter

267672
stoichiometry: 1.0
species: 404220
type: SpeciesReference

269472
stoichiometry: 1.0
species: 403620
type: SpeciesReference

410099
kinetic law: 266431
product: 266419
product: 266407
reactant: 266395
fast: false
reversible: false
type: Reaction

208249
units: 257862
value: 5.399946E-17
type: LocalParameter

207534
units: 257775
value: 2.0E-17
type: LocalParameter

207454
units: 257862
value: 0.0
type: LocalParameter

266599
stoichiometry: 1.0
species: 405720
type: SpeciesReference

273430
stoichiometry: 1.0
species: 404280
type: SpeciesReference

268056
stoichiometry: 1.0
species: 405460
type: SpeciesReference

207349
units: 257775
value: 0.0
type: LocalParameter

265741
stoichiometry: 1.0
species: 402200
type: SpeciesReference

412719
kinetic law: 272878
product: 272866
reactant: 272854
reactant: 272842
fast: false
reversible: true
type: Reaction

260765
stoichiometry: 1.0
species: 401100
type: SpeciesReference

267568
stoichiometry: 1.0
species: 401820
type: SpeciesReference

263916
local parameters: 207669
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

207422
units: 257775
value: 5.4E-15
type: LocalParameter

405740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

260316
local parameters: 207487
local parameters: 207485
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

207749
units: 257775
value: 1.8E-16
type: LocalParameter

266999
stoichiometry: 1.0
species: 402200
type: SpeciesReference

270776
stoichiometry: 1.0
species: 403180
type: SpeciesReference

413599
kinetic law: 275002
product: 274990
reactant: 274978
reactant: 274966
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

207493
units: 257862
value: 1.9805958E-18
type: LocalParameter

264049
stoichiometry: 1.0
species: 402280
type: SpeciesReference

410599
kinetic law: 267647
product: 267634
reactant: 267621
reactant: 267608
fast: false
reversible: true
type: Reaction

265329
stoichiometry: 1.0
species: 402540
type: SpeciesReference

401000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

262704
local parameters: 207609
local parameters: 207607
notes: k1*PP1_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

272488
local parameters: 208114
local parameters: 208112
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

263540
stoichiometry: 1.0
species: 401820
type: SpeciesReference

207496
units: 257775
value: 4.5E-17
type: LocalParameter

264510
stoichiometry: 1.0
species: 405460
type: SpeciesReference

207671
units: 257862
value: 3.0779838E-17
type: LocalParameter

269105
stoichiometry: 1.0
species: 403540
type: SpeciesReference

258544
local parameters: 207370
local parameters: 207368
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM
type: KineticLaw

409539
kinetic law: 265076
product: 265064
product: 265052
reactant: 265040
fast: false
reversible: false
type: Reaction

268514
local parameters: 207908
local parameters: 207906
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

271972
stoichiometry: 1.0
species: 404280
type: SpeciesReference

412579
kinetic law: 272540
product: 272528
product: 272515
reactant: 272502
fast: false
reversible: false
type: Reaction

269154
stoichiometry: 1.0
species: 405460
type: SpeciesReference

274543
stoichiometry: 1.0
species: 405700
type: SpeciesReference

271828
stoichiometry: 1.0
species: 405580
type: SpeciesReference

207537
units: 257862
value: 2.77776E-19
type: LocalParameter

272502
stoichiometry: 1.0
species: 404540
type: SpeciesReference

270728
stoichiometry: 1.0
species: 403880
type: SpeciesReference

207495
units: 257775
value: 1.8E-16
type: LocalParameter

207804
units: 257775
value: 1.8E-16
type: LocalParameter

274832
stoichiometry: 1.0
species: 401000
type: SpeciesReference

263308
stoichiometry: 1.0
species: 400840
type: SpeciesReference

207899
units: 257775
value: 5.4E-16
type: LocalParameter

269930
stoichiometry: 1.0
species: 405520
type: SpeciesReference

258278
stoichiometry: 1.0
species: 401720
type: SpeciesReference

207577
units: 257862
value: 2.77776E-19
type: LocalParameter

405020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

274192
stoichiometry: 1.0
species: 405620
type: SpeciesReference

208191
units: 257775
value: 1.4E-17
type: LocalParameter

268550
stoichiometry: 1.0
species: 403180
type: SpeciesReference

265391
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207898
units: 257775
value: 2.16E-15
type: LocalParameter

259140
local parameters: 207409
local parameters: 207407
notes: kf*CaM_slash_CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB
type: KineticLaw

261592
stoichiometry: 1.0
species: 405500
type: SpeciesReference

266033
stoichiometry: 1.0
species: 402200
type: SpeciesReference

263235
local parameters: 207635
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

267083
stoichiometry: 1.0
species: 405620
type: SpeciesReference

407479
kinetic law: 259927
product: 259915
product: 259903
reactant: 259890
fast: false
reversible: true
type: Reaction

267960
stoichiometry: 1.0
species: 405420
type: SpeciesReference

404800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

264157
local parameters: 207683
local parameters: 207681
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

410119
kinetic law: 266479
product: 266467
reactant: 266455
reactant: 266443
fast: false
reversible: true
type: Reaction

271574
stoichiometry: 1.0
species: 400980
type: SpeciesReference

266939
stoichiometry: 1.0
species: 402200
type: SpeciesReference

410819
kinetic law: 268225
product: 268213
reactant: 268200
reactant: 268188
fast: false
reversible: true
type: Reaction

405960
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400700
type: Species

207498
units: 257862
value: 1.5428556E-17
type: LocalParameter

267155
local parameters: 207838
local parameters: 207836
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

402340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

400820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

263649
stoichiometry: 1.0
species: 402140
type: SpeciesReference

275038
stoichiometry: 1.0
species: 401560
type: SpeciesReference

404700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

258737
stoichiometry: 1.0
species: 401640
type: SpeciesReference

267492
local parameters: 207854
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

401620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

263272
stoichiometry: 1.0
species: 402040
type: SpeciesReference

259441
stoichiometry: 1.0
species: 403180
type: SpeciesReference

271429
stoichiometry: 1.0
species: 404320
type: SpeciesReference

401940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 400680
type: Species

207539
units: 257775
value: 2.0E-17
type: LocalParameter

413379
kinetic law: 274470
product: 274458
product: 274446
reactant: 274434
fast: false
reversible: false
type: Reaction

260278
local parameters: 207484
local parameters: 207482
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

207579
units: 257775
value: 2.0E-17
type: LocalParameter

260425
stoichiometry: 1.0
species: 400780
type: SpeciesReference

261068
stoichiometry: 1.0
species: 405700
type: SpeciesReference

401080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207806
units: 257862
value: 2.011824E-17
type: LocalParameter

265850
local parameters: 207769
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

410779
kinetic law: 268128
product: 268116
reactant: 268104
reactant: 268092
fast: false
reversible: true
type: Reaction

207896
units: 257862
value: 3.5998992E-16
type: LocalParameter

273514
stoichiometry: 1.0
species: 405620
type: SpeciesReference

409459
kinetic law: 264884
product: 264872
product: 264860
reactant: 264848
fast: false
reversible: false
type: Reaction

264229
stoichiometry: 1.0
species: 402200
type: SpeciesReference

259817
stoichiometry: 1.0
species: 405840
type: SpeciesReference

261968
local parameters: 207570
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

405920
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 400680
type: Species

410859
kinetic law: 268321
product: 268309
reactant: 268297
reactant: 268285
fast: false
reversible: true
type: Reaction

271864
stoichiometry: 1.0
species: 405580
type: SpeciesReference

265925
stoichiometry: 1.0
species: 405580
type: SpeciesReference

269568
stoichiometry: 1.0
species: 403640
type: SpeciesReference

261664
stoichiometry: 1.0
species: 406100
type: SpeciesReference

266105
stoichiometry: 1.0
species: 402720
type: SpeciesReference

262030
stoichiometry: 1.0
species: 401380
type: SpeciesReference

207801
units: 257862
value: 2.011824E-17
type: LocalParameter

269215
stoichiometry: 1.0
species: 405340
type: SpeciesReference

207781
units: 257862
value: 2.011824E-17
type: LocalParameter

274506
stoichiometry: 1.0
species: 404960
type: SpeciesReference

269191
local parameters: 207943
local parameters: 207941
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

268899
local parameters: 207928
local parameters: 207926
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

272588
local parameters: 208120
local parameters: 208118
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

259297
stoichiometry: 1.0
species: 404160
type: SpeciesReference

208244
units: 257862
value: 5.507838E-18
type: LocalParameter

258121
local parameters: 207343
local parameters: 207341
notes: kf*CaMKII_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_slash_NMDAR
type: KineticLaw

409859
kinetic law: 265850
product: 265838
product: 265826
reactant: 265814
fast: false
reversible: false
type: Reaction

207428
units: 257862
value: 5.399946E-15
type: LocalParameter

207893
units: 257775
value: 2.16E-15
type: LocalParameter

271031
local parameters: 208039
local parameters: 208037
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

271465
local parameters: 208060
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

270945
stoichiometry: 1.0
species: 404000
type: SpeciesReference

259213
stoichiometry: 1.0
species: 404160
type: SpeciesReference

407939
kinetic law: 261044
product: 261032
reactant: 261020
reactant: 261007
fast: false
reversible: true
type: Reaction

261445
stoichiometry: 1.0
species: 401260
type: SpeciesReference

412199
kinetic law: 271610
product: 271598
reactant: 271586
reactant: 271574
fast: false
reversible: true
type: Reaction

407879
kinetic law: 260899
product: 260886
product: 260874
reactant: 260862
fast: false
reversible: false
type: Reaction

404580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

411219
kinetic law: 269239
product: 269227
product: 269215
reactant: 269203
fast: false
reversible: false
type: Reaction

408539
kinetic law: 262602
product: 262589
reactant: 262576
reactant: 262563
fast: false
reversible: true
type: Reaction

272286
local parameters: 208104
local parameters: 208102
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

263989
stoichiometry: 1.0
species: 401860
type: SpeciesReference

266250
stoichiometry: 1.0
species: 405760
type: SpeciesReference

272770
stoichiometry: 1.0
species: 404600
type: SpeciesReference

207894
units: 257775
value: 5.4E-16
type: LocalParameter

407979
kinetic law: 261141
product: 261128
reactant: 261116
reactant: 261104
fast: false
reversible: true
type: Reaction

207803
units: 257775
value: 7.2E-16
type: LocalParameter

404500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

411639
kinetic law: 270257
product: 270244
reactant: 270232
reactant: 270220
fast: false
reversible: true
type: Reaction

401420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700
type: Species

273478
stoichiometry: 1.0
species: 405560
type: SpeciesReference

272926
local parameters: 208136
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

408119
kinetic law: 261531
product: 261519
reactant: 261506
reactant: 261494
fast: false
reversible: true
type: Reaction

273623
stoichiometry: 1.0
species: 404280
type: SpeciesReference

273370
stoichiometry: 1.0
species: 404720
type: SpeciesReference

270305
local parameters: 207999
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

265136
stoichiometry: 1.0
species: 402500
type: SpeciesReference

207701
units: 257862
value: 1.8106416E-16
type: LocalParameter

266951
stoichiometry: 1.0
species: 402900
type: SpeciesReference

260461
local parameters: 207495
local parameters: 207493
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

207741
units: 257862
value: 1.8106416E-16
type: LocalParameter

403940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 400680
type: Species

208242
units: 257775
value: 5.22E-17
type: LocalParameter

207891
units: 257862
value: 3.5998992E-16
type: LocalParameter

410279
kinetic law: 266866
product: 266854
reactant: 266842
reactant: 266830
fast: false
reversible: true
type: Reaction

270160
local parameters: 207993
local parameters: 207991
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

405100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 400680
type: Species

264692
local parameters: 207709
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

264001
stoichiometry: 1.0
species: 402200
type: SpeciesReference

264956
stoichiometry: 1.0
species: 405440
type: SpeciesReference

263381
local parameters: 207643
local parameters: 207642
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

258628
local parameters: 207376
local parameters: 207374
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

273118
local parameters: 208147
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

405260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

401380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

265535
stoichiometry: 1.0
species: 405240
type: SpeciesReference

405420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270982
local parameters: 208035
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

270220
stoichiometry: 1.0
species: 405540
type: SpeciesReference

404240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

265257
stoichiometry: 1.0
species: 402200
type: SpeciesReference

268598
stoichiometry: 1.0
species: 403440
type: SpeciesReference

274434
stoichiometry: 1.0
species: 404940
type: SpeciesReference

406960
kinetic law: 258218
product: 258206
reactant: 258193
reactant: 258181
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

266671
local parameters: 207813
local parameters: 207811
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

208241
units: 257775
value: 2.106E-16
type: LocalParameter

411679
kinetic law: 270353
product: 270341
reactant: 270329
reactant: 270317
fast: false
reversible: true
type: Reaction

259866
stoichiometry: 1.0
species: 405840
type: SpeciesReference

262489
stoichiometry: 1.0
species: 401480
type: SpeciesReference

273010
stoichiometry: 1.0
species: 404280
type: SpeciesReference

404180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400700
type: Species

265173
local parameters: 207734
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

265973
stoichiometry: 1.0
species: 402200
type: SpeciesReference

267518
stoichiometry: 1.0
species: 403180
type: SpeciesReference

408679
kinetic law: 262944
product: 262932
product: 262920
reactant: 262908
fast: false
reversible: false
type: Reaction

273782
stoichiometry: 1.0
species: 404280
type: SpeciesReference

263017
stoichiometry: 1.0
species: 404260
type: SpeciesReference

266190
local parameters: 207788
local parameters: 207786
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

266214
stoichiometry: 1.0
species: 405700
type: SpeciesReference

268959
stoichiometry: 1.0
species: 405240
type: SpeciesReference

208095
units: 257775
value: 1.7E-18
type: LocalParameter

271189
stoichiometry: 1.0
species: 404160
type: SpeciesReference

207784
units: 257775
value: 1.8E-16
type: LocalParameter

258338
stoichiometry: 1.0
species: 401060
type: SpeciesReference

401720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

267804
stoichiometry: 1.0
species: 405200
type: SpeciesReference

408719
kinetic law: 263041
product: 263029
product: 263017
reactant: 263005
fast: false
reversible: false
type: Reaction

268092
stoichiometry: 1.0
species: 405180
type: SpeciesReference

403120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

404920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

208128
units: 257862
value: 8.7498E-18
type: LocalParameter

261809
stoichiometry: 1.0
species: 401340
type: SpeciesReference

269081
stoichiometry: 1.0
species: 403540
type: SpeciesReference

413219
kinetic law: 274083
product: 274071
product: 274059
reactant: 274047
fast: false
reversible: false
type: Reaction

273274
stoichiometry: 1.0
species: 404700
type: SpeciesReference

413199
kinetic law: 274035
product: 274023
reactant: 274011
reactant: 273999
fast: false
reversible: true
type: Reaction

259249
stoichiometry: 1.0
species: 403040
type: SpeciesReference

411979
kinetic law: 271079
product: 271067
product: 271055
reactant: 271043
fast: false
reversible: false
type: Reaction

260204
local parameters: 207478
local parameters: 207476
notes: kf*AMPAR_memb_slash_GluR23_M-kb*AMPAR_slash_GluR23_I
type: KineticLaw

265790
stoichiometry: 1.0
species: 402660
type: SpeciesReference

257939
stoichiometry: 1.0
species: 401780
type: SpeciesReference

266419
stoichiometry: 1.0
species: 402200
type: SpeciesReference

408799
kinetic law: 263235
product: 263222
product: 263210
reactant: 263198
fast: false
reversible: false
type: Reaction

263480
local parameters: 207648
local parameters: 207646
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

263866
local parameters: 207668
local parameters: 207666
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

207678
units: 257775
value: 1.224E-16
type: LocalParameter

261385
local parameters: 207540
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

408759
kinetic law: 263137
product: 263125
product: 263113
reactant: 263101
fast: false
reversible: false
type: Reaction

407100
kinetic law: 258544
product: 258531
reactant: 258519
reactant: 258507
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

208097
units: 257862
value: 8.7498E-18
type: LocalParameter

271647
stoichiometry: 1.0
species: 404280
type: SpeciesReference

263818
local parameters: 207664
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

260691
stoichiometry: 1.0
species: 406000
type: SpeciesReference

259963
stoichiometry: 1.0
species: 405840
type: SpeciesReference

270401
local parameters: 208004
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

207679
units: 257775
value: 3.06E-17
type: LocalParameter

409359
kinetic law: 264644
product: 264632
reactant: 264620
reactant: 264608
fast: false
reversible: true
type: Reaction

411379
kinetic law: 269629
product: 269617
product: 269605
reactant: 269592
fast: false
reversible: false
type: Reaction

258507
stoichiometry: 1.0
species: 401580
type: SpeciesReference

264836
local parameters: 207718
local parameters: 207716
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

260546
stoichiometry: 1.0
species: 400900
type: SpeciesReference

272733
local parameters: 208126
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

267372
stoichiometry: 1.0
species: 401640
type: SpeciesReference

274772
stoichiometry: 1.0
species: 400960
type: SpeciesReference

406220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

261274
stoichiometry: 1.0
species: 406100
type: SpeciesReference

268730
stoichiometry: 1.0
species: 405320
type: SpeciesReference

269678
local parameters: 207968
local parameters: 207966
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

273586
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207639
units: 257775
value: 9.0E-16
type: LocalParameter

207783
units: 257775
value: 7.2E-16
type: LocalParameter

207570
units: 257775
value: 5.0E-18
type: LocalParameter

263952
stoichiometry: 1.0
species: 402260
type: SpeciesReference

264584
stoichiometry: 1.0
species: 402200
type: SpeciesReference

269044
local parameters: 207934
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

258495
local parameters: 207367
local parameters: 207365
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_slash_CaM_minus_Ca3
type: KineticLaw

207811
units: 257862
value: 2.011824E-17
type: LocalParameter

265100
stoichiometry: 1.0
species: 402200
type: SpeciesReference

274482
stoichiometry: 1.0
species: 405740
type: SpeciesReference

207901
units: 257862
value: 3.5998992E-16
type: LocalParameter

259586
stoichiometry: 1.0
species: 403980
type: SpeciesReference

266745
stoichiometry: 1.0
species: 402200
type: SpeciesReference

261845
stoichiometry: 1.0
species: 405740
type: SpeciesReference

208099
units: 257775
value: 6.8E-18
type: LocalParameter

405700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207789
units: 257775
value: 1.8E-16
type: LocalParameter

262740
stoichiometry: 1.0
species: 401880
type: SpeciesReference

207676
units: 257862
value: 3.420036E-18
type: LocalParameter

413439
kinetic law: 274615
product: 274603
reactant: 274591
reactant: 274579
fast: false
reversible: true
type: Reaction

208125
units: 257775
value: 1.4E-17
type: LocalParameter

401100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

262441
stoichiometry: 1.0
species: 406100
type: SpeciesReference

413159
kinetic law: 273939
product: 273927
reactant: 273915
reactant: 273903
fast: false
reversible: true
type: Reaction

260498
stoichiometry: 1.0
species: 405980
type: SpeciesReference

273818
stoichiometry: 1.0
species: 404280
type: SpeciesReference

405360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207788
units: 257775
value: 7.2E-16
type: LocalParameter

261519
stoichiometry: 1.0
species: 401280
type: SpeciesReference

263125
stoichiometry: 1.0
species: 401980
type: SpeciesReference

207386
units: 257775
value: 5.0E-20
type: LocalParameter

258592
stoichiometry: 1.0
species: 401600
type: SpeciesReference

404060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 400680
type: Species

208011
units: 257862
value: 3.999888E-17
type: LocalParameter

413119
kinetic law: 273842
product: 273830
reactant: 273818
reactant: 273806
fast: false
reversible: true
type: Reaction

268369
local parameters: 207899
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

207637
units: 257862
value: 2.2062942E-16
type: LocalParameter

262538
stoichiometry: 1.0
species: 406120
type: SpeciesReference

405320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

267227
stoichiometry: 1.0
species: 402200
type: SpeciesReference

265463
local parameters: 207749
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

410059
kinetic law: 266335
product: 266322
product: 266310
reactant: 266298
fast: false
reversible: false
type: Reaction

269786
stoichiometry: 1.0
species: 403680
type: SpeciesReference

264437
stoichiometry: 1.0
species: 402360
type: SpeciesReference

207572
units: 257862
value: 2.77776E-19
type: LocalParameter

268802
local parameters: 207923
local parameters: 207921
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

261882
stoichiometry: 1.0
species: 405660
type: SpeciesReference

271237
stoichiometry: 1.0
species: 404120
type: SpeciesReference

266081
stoichiometry: 1.0
species: 402720
type: SpeciesReference

407259
kinetic law: 258991
product: 258979
product: 258967
reactant: 258955
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

261226
stoichiometry: 1.0
species: 401220
type: SpeciesReference

264377
stoichiometry: 1.0
species: 405200
type: SpeciesReference

403480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

407199
kinetic law: 258809
product: 258797
reactant: 258785
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

207903
units: 257775
value: 2.16E-15
type: LocalParameter

207389
units: 257862
value: 4.1849946E-17
type: LocalParameter

401780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

267912
stoichiometry: 1.0
species: 403180
type: SpeciesReference

267264
stoichiometry: 1.0
species: 402960
type: SpeciesReference

271768
stoichiometry: 1.0
species: 405680
type: SpeciesReference

208014
units: 257775
value: 5.4E-16
type: LocalParameter

207674
units: 257775
value: 3.06E-17
type: LocalParameter

260071
local parameters: 207469
local parameters: 207467
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_
type: KineticLaw

259648
local parameters: 207442
local parameters: 207440
notes: kf*AC_slash_PDE1*CaM_slash_CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1
type: KineticLaw

407339
kinetic law: 259381
product: 259369
product: 259357
reactant: 259345
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true
type: Reaction

261919
local parameters: 207569
local parameters: 207567
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

410919
kinetic law: 268465
product: 268453
product: 268441
reactant: 268429
fast: false
reversible: false
type: Reaction

273707
stoichiometry: 1.0
species: 405780
type: SpeciesReference

270498
local parameters: 208009
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

403400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207575
units: 257775
value: 5.0E-18
type: LocalParameter

407480
kinetic law: 259975
product: 259963
product: 259951
reactant: 259939
fast: false
reversible: true
type: Reaction

273695
local parameters: 208177
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

262576
stoichiometry: 1.0
species: 406120
type: SpeciesReference

273406
local parameters: 208162
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

207786
units: 257862
value: 2.011824E-17
type: LocalParameter

267191
stoichiometry: 1.0
species: 402200
type: SpeciesReference

270510
stoichiometry: 1.0
species: 405620
type: SpeciesReference

207904
units: 257775
value: 5.4E-16
type: LocalParameter

207635
units: 257775
value: 2.25E-16
type: LocalParameter

270269
stoichiometry: 1.0
species: 403780
type: SpeciesReference

262641
stoichiometry: 1.0
species: 406120
type: SpeciesReference

207388
units: 257775
value: 0.0
type: LocalParameter

403440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

266298
stoichiometry: 1.0
species: 402760
type: SpeciesReference

409419
kinetic law: 264788
product: 264776
product: 264764
reactant: 264752
fast: false
reversible: false
type: Reaction

405780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

208013
units: 257775
value: 2.16E-15
type: LocalParameter

207673
units: 257775
value: 1.224E-16
type: LocalParameter

264474
stoichiometry: 1.0
species: 405400
type: SpeciesReference

260582
stoichiometry: 1.0
species: 400820
type: SpeciesReference

208126
units: 257775
value: 3.5E-18
type: LocalParameter

207574
units: 257775
value: 2.0E-17
type: LocalParameter

263162
stoichiometry: 1.0
species: 401980
type: SpeciesReference

412759
kinetic law: 272974
product: 272962
reactant: 272950
reactant: 272938
fast: false
reversible: true
type: Reaction

265802
local parameters: 207768
local parameters: 207766
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

266455
stoichiometry: 1.0
species: 402200
type: SpeciesReference

410959
kinetic law: 268562
product: 268550
product: 268538
reactant: 268526
fast: false
reversible: false
type: Reaction

267119
stoichiometry: 1.0
species: 405620
type: SpeciesReference

273744
local parameters: 208181
local parameters: 208179
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

265754
local parameters: 207764
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

411579
kinetic law: 270111
product: 270098
product: 270086
reactant: 270074
fast: false
reversible: false
type: Reaction

402760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258845
stoichiometry: 1.0
species: 401780
type: SpeciesReference

207634
units: 257775
value: 9.0E-16
type: LocalParameter

263757
stoichiometry: 1.0
species: 402220
type: SpeciesReference

408499
kinetic law: 262501
product: 262489
reactant: 262477
reactant: 262465
fast: false
reversible: true
type: Reaction

268490
stoichiometry: 1.0
species: 403180
type: SpeciesReference

264776
stoichiometry: 1.0
species: 402200
type: SpeciesReference

261628
local parameters: 207554
local parameters: 207552
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

272237
local parameters: 208100
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

259028
stoichiometry: 1.0
species: 402140
type: SpeciesReference

207739
units: 257775
value: 1.8E-16
type: LocalParameter

260389
stoichiometry: 1.0
species: 400820
type: SpeciesReference

269906
stoichiometry: 1.0
species: 403180
type: SpeciesReference

259537
stoichiometry: 1.0
species: 403920
type: SpeciesReference

208016
units: 257862
value: 3.999888E-17
type: LocalParameter

260825
stoichiometry: 1.0
species: 406060
type: SpeciesReference

270050
stoichiometry: 1.0
species: 403740
type: SpeciesReference

401040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

402060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207383
units: 257862
value: 3.0E-18
type: LocalParameter

401900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 400680
type: Species

411899
kinetic law: 270885
modifier: 270873
product: 270861
reactant: 270849
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false
type: Reaction

208121
units: 257775
value: 3.5E-18
type: LocalParameter

402920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

268213
stoichiometry: 1.0
species: 403360
type: SpeciesReference

400860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 400680
type: Species

259321
stoichiometry: 1.0
species: 403080
type: SpeciesReference

207632
units: 257862
value: 2.2062942E-16
type: LocalParameter

261773
local parameters: 207560
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

268911
stoichiometry: 1.0
species: 403500
type: SpeciesReference

273855
stoichiometry: 1.0
species: 404820
type: SpeciesReference

411199
kinetic law: 269191
product: 269179
reactant: 269166
reactant: 269154
fast: false
reversible: true
type: Reaction

409999
kinetic law: 266190
product: 266178
reactant: 266166
reactant: 266154
fast: false
reversible: true
type: Reaction

207343
units: 257862
value: 5.4E-21
type: LocalParameter

402020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

409959
kinetic law: 266093
product: 266081
reactant: 266069
reactant: 266057
fast: false
reversible: true
type: Reaction

274047
stoichiometry: 1.0
species: 404860
type: SpeciesReference

402600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

260619
stoichiometry: 1.0
species: 400780
type: SpeciesReference

265572
stoichiometry: 1.0
species: 405320
type: SpeciesReference

207961
units: 257862
value: 3.999888E-17
type: LocalParameter

207382
units: 257775
value: 1.0E-16
type: LocalParameter

208120
units: 257775
value: 1.4E-17
type: LocalParameter

207455
units: 257775
value: 8.0E-21
type: LocalParameter

207856
units: 257862
value: 5.399946E-16
type: LocalParameter

207906
units: 257862
value: 3.5998992E-16
type: LocalParameter

258773
local parameters: 207385
local parameters: 207383
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD
type: KineticLaw

265644
stoichiometry: 1.0
species: 402200
type: SpeciesReference

408279
kinetic law: 261919
product: 261907
reactant: 261894
reactant: 261882
fast: false
reversible: true
type: Reaction

403620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

268164
stoichiometry: 1.0
species: 403180
type: SpeciesReference

261116
stoichiometry: 1.0
species: 406100
type: SpeciesReference

402980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

271127
local parameters: 208044
local parameters: 208042
notes: k1*AC_slash_cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

270341
stoichiometry: 1.0
species: 403800
type: SpeciesReference

274905
local parameters: 208241
local parameters: 208239
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

260935
stoichiometry: 1.0
species: 401160
type: SpeciesReference

208050
units: 257775
value: 9.0E-16
type: LocalParameter

269702
stoichiometry: 1.0
species: 405760
type: SpeciesReference

402380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272177
stoichiometry: 1.0
species: 404480
type: SpeciesReference

268778
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207344
units: 257862
value: 1.08E-20
type: LocalParameter

266563
stoichiometry: 1.0
species: 402820
type: SpeciesReference

411859
kinetic law: 270788
product: 270776
product: 270764
reactant: 270752
fast: false
reversible: false
type: Reaction

208123
units: 257862
value: 8.7498E-18
type: LocalParameter

258024
local parameters: 207337
local parameters: 207335
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_slash_CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

208018
units: 257775
value: 2.16E-15
type: LocalParameter

207859
units: 257775
value: 8.1E-16
type: LocalParameter

262114
local parameters: 207579
local parameters: 207577
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

412459
kinetic law: 272237
product: 272225
product: 272213
reactant: 272201
fast: false
reversible: false
type: Reaction

410219
kinetic law: 266720
product: 266708
product: 266696
reactant: 266683
fast: false
reversible: false
type: Reaction

264656
stoichiometry: 1.0
species: 402400
type: SpeciesReference

207385
units: 257775
value: 1.0E-17
type: LocalParameter

207458
units: 257775
value: 8.0E-21
type: LocalParameter

268008
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207630
units: 257775
value: 2.25E-16
type: LocalParameter

412419
kinetic law: 272140
product: 272128
product: 272116
reactant: 272104
fast: false
reversible: false
type: Reaction

208090
units: 257775
value: 1.7E-18
type: LocalParameter

410739
kinetic law: 268032
product: 268020
reactant: 268008
reactant: 267996
fast: false
reversible: true
type: Reaction

274942
stoichiometry: 1.0
species: 405040
type: SpeciesReference

275182
stoichiometry: 1.0
species: 405040
type: SpeciesReference

273166
local parameters: 208151
local parameters: 208149
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

207963
units: 257775
value: 2.16E-15
type: LocalParameter

269580
local parameters: 207963
local parameters: 207961
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

207908
units: 257775
value: 2.16E-15
type: LocalParameter

411819
kinetic law: 270692
product: 270680
product: 270668
reactant: 270656
fast: false
reversible: false
type: Reaction

409919
kinetic law: 265997
product: 265985
reactant: 265973
reactant: 265961
fast: false
reversible: true
type: Reaction

260023
local parameters: 207466
local parameters: 207464
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_
type: KineticLaw

207457
units: 257862
value: 0.0
type: LocalParameter

207858
units: 257775
value: 3.24E-15
type: LocalParameter

404320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

406920
kinetic law: 258121
product: 258109
product: 258096
reactant: 258084
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true
type: Reaction

208052
units: 257862
value: 6.2502E-17
type: LocalParameter

409819
kinetic law: 265754
product: 265741
product: 265728
reactant: 265716
fast: false
reversible: false
type: Reaction

208201
units: 257775
value: 1.4E-17
type: LocalParameter

413619
kinetic law: 275062
product: 275050
product: 275038
product: 275026
reactant: 275014
fast: false
reversible: false
type: Reaction

404640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

275146
stoichiometry: 1.0
species: 405040
type: SpeciesReference

258447
local parameters: 207364
local parameters: 207362
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2
type: KineticLaw

262260
local parameters: 207585
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

272322
stoichiometry: 1.0
species: 404280
type: SpeciesReference

274156
stoichiometry: 1.0
species: 405720
type: SpeciesReference

268622
stoichiometry: 1.0
species: 403440
type: SpeciesReference

262296
stoichiometry: 1.0
species: 401440
type: SpeciesReference

273891
local parameters: 208187
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

267456
stoichiometry: 1.0
species: 403200
type: SpeciesReference

403160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

264884
local parameters: 207719
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

207909
units: 257775
value: 5.4E-16
type: LocalParameter

410379
kinetic law: 267107
product: 267095
product: 267083
reactant: 267071
fast: false
reversible: false
type: Reaction

409699
kinetic law: 265463
product: 265451
product: 265439
reactant: 265427
fast: false
reversible: false
type: Reaction

207964
units: 257775
value: 5.4E-16
type: LocalParameter

265064
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207966
units: 257862
value: 3.999888E-17
type: LocalParameter

272020
stoichiometry: 1.0
species: 405500
type: SpeciesReference

405140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208202
units: 257775
value: 3.5E-18
type: LocalParameter

272383
local parameters: 208109
local parameters: 208107
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

273963
stoichiometry: 1.0
species: 405500
type: SpeciesReference

260995
local parameters: 207520
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

207851
units: 257862
value: 5.399946E-16
type: LocalParameter

409099
kinetic law: 264013
product: 264001
product: 263989
reactant: 263977
fast: false
reversible: false
type: Reaction

404600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

275302
local parameters: 208261
local parameters: 208259
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

275074
stoichiometry: 1.0
species: 403940
type: SpeciesReference

208092
units: 257862
value: 8.7498E-18
type: LocalParameter

404540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

269314
stoichiometry: 1.0
species: 405680
type: SpeciesReference

271297
stoichiometry: 1.0
species: 404280
type: SpeciesReference

413659
kinetic law: 275158
product: 275146
product: 275134
reactant: 275122
fast: false
reversible: false
type: Reaction

208019
units: 257775
value: 5.4E-16
type: LocalParameter

407839
kinetic law: 260801
product: 260789
product: 260777
reactant: 260765
fast: false
reversible: false
type: Reaction

272128
stoichiometry: 1.0
species: 404280
type: SpeciesReference

272436
local parameters: 208110
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

268321
local parameters: 207898
local parameters: 207896
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

401460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

409019
kinetic law: 263818
product: 263806
product: 263794
reactant: 263782
fast: false
reversible: false
type: Reaction

265680
stoichiometry: 1.0
species: 402200
type: SpeciesReference

270558
stoichiometry: 1.0
species: 403840
type: SpeciesReference

208054
units: 257775
value: 1.0E-16
type: LocalParameter

272842
stoichiometry: 1.0
species: 405780
type: SpeciesReference

274699
stoichiometry: 1.0
species: 405000
type: SpeciesReference

274083
local parameters: 208197
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

207854
units: 257775
value: 8.1E-16
type: LocalParameter

207340
units: 257862
value: 5.4E-21
type: LocalParameter

263467
stoichiometry: 1.0
species: 402080
type: SpeciesReference

409799
kinetic law: 265704
product: 265692
reactant: 265680
reactant: 265668
fast: false
reversible: true
type: Reaction

266142
local parameters: 207784
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

259854
stoichiometry: 1.0
species: 405400
type: SpeciesReference

401520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 400680
type: Species

263053
stoichiometry: 1.0
species: 400800
type: SpeciesReference

406380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

259708
stoichiometry: 1.0
species: 404200
type: SpeciesReference

208189
units: 257862
value: 8.7498E-18
type: LocalParameter

410660
kinetic law: 267840
product: 267828
reactant: 267816
reactant: 267804
fast: false
reversible: true
type: Reaction

261166
stoichiometry: 1.0
species: 405600
type: SpeciesReference

271538
stoichiometry: 1.0
species: 401040
type: SpeciesReference

259115
stoichiometry: 1.0
species: 402140
type: SpeciesReference

261494
stoichiometry: 1.0
species: 405580
type: SpeciesReference

270619
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274204
stoichiometry: 1.0
species: 404280
type: SpeciesReference

404680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

267852
stoichiometry: 1.0
species: 403280
type: SpeciesReference

269263
stoichiometry: 1.0
species: 403180
type: SpeciesReference

258386
stoichiometry: 1.0
species: 401080
type: SpeciesReference

262223
stoichiometry: 1.0
species: 401420
type: SpeciesReference

260971
stoichiometry: 1.0
species: 405760
type: SpeciesReference

411159
kinetic law: 269093
product: 269081
reactant: 269069
reactant: 269056
fast: false
reversible: true
type: Reaction

208204
units: 257862
value: 8.7498E-18
type: LocalParameter

207341
units: 257775
value: 3.0E-18
type: LocalParameter

207968
units: 257775
value: 2.16E-15
type: LocalParameter

274373
local parameters: 208212
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

207853
units: 257775
value: 3.24E-15
type: LocalParameter

406400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

259065
stoichiometry: 2.0
species: 400740
type: SpeciesReference

264266
stoichiometry: 1.0
species: 402320
type: SpeciesReference

208094
units: 257775
value: 6.8E-18
type: LocalParameter

404960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

273226
stoichiometry: 1.0
species: 405800
type: SpeciesReference

400680
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

409059
kinetic law: 263916
product: 263904
product: 263891
reactant: 263879
fast: false
reversible: false
type: Reaction

266635
stoichiometry: 1.0
species: 405780
type: SpeciesReference

261737
stoichiometry: 1.0
species: 401320
type: SpeciesReference

409759
kinetic law: 265608
product: 265596
reactant: 265584
reactant: 265572
fast: false
reversible: true
type: Reaction

271936
stoichiometry: 1.0
species: 404280
type: SpeciesReference

274881
stoichiometry: 1.0
species: 405040
type: SpeciesReference

270450
local parameters: 208008
local parameters: 208006
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

207380
units: 257862
value: 4.65012E-18
type: LocalParameter

268273
local parameters: 207894
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

266527
local parameters: 207804
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

260886
stoichiometry: 1.0
species: 406060
type: SpeciesReference

405820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 400700
type: Species

409319
kinetic law: 264548
product: 264535
reactant: 264523
reactant: 264510
fast: false
reversible: true
type: Reaction

274288
stoichiometry: 1.0
species: 405560
type: SpeciesReference

265353
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208234
units: 257862
value: 2.45142E-17
type: LocalParameter

261032
stoichiometry: 1.0
species: 401180
type: SpeciesReference

260340
stoichiometry: 1.0
species: 405980
type: SpeciesReference

411559
kinetic law: 270062
product: 270050
reactant: 270038
reactant: 270026
fast: false
reversible: true
type: Reaction

269374
stoichiometry: 1.0
species: 403600
type: SpeciesReference

259477
local parameters: 207430
local parameters: 207428
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA
type: KineticLaw

207461
units: 257775
value: 8.0E-21
type: LocalParameter

266854
stoichiometry: 1.0
species: 402880
type: SpeciesReference

259768
stoichiometry: 1.0
species: 404240
type: SpeciesReference

261932
stoichiometry: 1.0
species: 401360
type: SpeciesReference

274240
stoichiometry: 1.0
species: 404900
type: SpeciesReference

274736
stoichiometry: 1.0
species: 405520
type: SpeciesReference

262920
stoichiometry: 1.0
species: 404200
type: SpeciesReference

207413
units: 257862
value: 4.86E-15
type: LocalParameter

266322
stoichiometry: 1.0
species: 402200
type: SpeciesReference

269834
stoichiometry: 1.0
species: 405520
type: SpeciesReference

265439
stoichiometry: 1.0
species: 405220
type: SpeciesReference

408059
kinetic law: 261336
product: 261324
reactant: 261311
reactant: 261299
fast: false
reversible: true
type: Reaction

207758
units: 257775
value: 7.2E-16
type: LocalParameter

267348
local parameters: 207848
local parameters: 207846
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

270570
stoichiometry: 1.0
species: 405800
type: SpeciesReference

262344
stoichiometry: 1.0
species: 406100
type: SpeciesReference

407779
kinetic law: 260655
product: 260643
reactant: 260631
reactant: 260619
fast: false
reversible: true
type: Reaction

270656
stoichiometry: 1.0
species: 403860
type: SpeciesReference

409639
kinetic law: 265317
product: 265305
reactant: 265293
reactant: 265281
fast: false
reversible: true
type: Reaction

272986
stoichiometry: 1.0
species: 404640
type: SpeciesReference

274337
stoichiometry: 1.0
species: 404920
type: SpeciesReference

402200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207415
units: 257775
value: 2.97E-15
type: LocalParameter

264121
stoichiometry: 1.0
species: 404240
type: SpeciesReference

263709
stoichiometry: 1.0
species: 402140
type: SpeciesReference

406260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

264193
stoichiometry: 1.0
species: 402200
type: SpeciesReference

405860
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680
type: Species

411519
kinetic law: 269966
product: 269954
reactant: 269942
reactant: 269930
fast: false
reversible: true
type: Reaction

208034
units: 257775
value: 3.6E-15
type: LocalParameter

407379
kinetic law: 259561
product: 259549
reactant: 259537
notes: Random rate.
fast: false
reversible: true
type: Reaction

272140
local parameters: 208095
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

263041
local parameters: 207625
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

402280
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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258242
stoichiometry: 1.0
species: 401140
type: SpeciesReference

410639
kinetic law: 267744
product: 267732
reactant: 267720
reactant: 267708
fast: false
reversible: true
type: Reaction

208236
units: 257775
value: 1.0E-16
type: LocalParameter

207756
units: 257862
value: 1.8106416E-16
type: LocalParameter

264992
stoichiometry: 1.0
species: 405280
type: SpeciesReference

405160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 400680
type: Species

275362
local parameters: 208262
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

261543
stoichiometry: 1.0
species: 401280
type: SpeciesReference

262175
stoichiometry: 1.0
species: 405700
type: SpeciesReference

264085
stoichiometry: 1.0
species: 404200
type: SpeciesReference

271345
stoichiometry: 1.0
species: 401060
type: SpeciesReference

208031
units: 257739
value: 300.001920012288
type: LocalParameter

412379
kinetic law: 272044
product: 272032
product: 272020
reactant: 272008
fast: false
reversible: false
type: Reaction

267408
stoichiometry: 1.0
species: 403980
type: SpeciesReference

407819
kinetic law: 260753
product: 260740
reactant: 260728
reactant: 260715
fast: false
reversible: true
type: Reaction

274627
stoichiometry: 1.0
species: 404980
type: SpeciesReference

402520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

260059
stoichiometry: 1.0
species: 405780
type: SpeciesReference

263576
local parameters: 207653
local parameters: 207651
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

270800
stoichiometry: 1.0
species: 405900
type: SpeciesReference

266395
stoichiometry: 1.0
species: 402780
type: SpeciesReference

402560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

260241
local parameters: 207481
local parameters: 207479
notes: kf*PKC_minus_control-kb*PKC_minus_active
type: KineticLaw

268670
stoichiometry: 1.0
species: 405360
type: SpeciesReference

408379
kinetic law: 262163
product: 262151
product: 262138
reactant: 262126
fast: false
reversible: false
type: Reaction

409679
kinetic law: 265415
product: 265403
reactant: 265391
reactant: 265378
fast: false
reversible: true
type: Reaction

207460
units: 257862
value: 0.0
type: LocalParameter

207754
units: 257775
value: 1.8E-16
type: LocalParameter

400900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 400680
type: Species

410399
kinetic law: 267155
product: 267143
reactant: 267131
reactant: 267119
fast: false
reversible: true
type: Reaction

262380
stoichiometry: 1.0
species: 406100
type: SpeciesReference

258967
stoichiometry: 1.0
species: 401980
type: SpeciesReference

267634
stoichiometry: 1.0
species: 403240
type: SpeciesReference

207969
units: 257775
value: 5.4E-16
type: LocalParameter

273334
stoichiometry: 1.0
species: 404280
type: SpeciesReference

273939
local parameters: 208191
local parameters: 208189
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

207412
units: 257775
value: 2.97E-15
type: LocalParameter

208032
units: 257862
value: 2.2680162E-16
type: LocalParameter

275218
stoichiometry: 1.0
species: 405120
type: SpeciesReference

268995
local parameters: 207933
local parameters: 207931
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

262602
local parameters: 207604
local parameters: 207602
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

261324
stoichiometry: 1.0
species: 401240
type: SpeciesReference

401140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700
type: Species

259696
stoichiometry: 1.0
species: 404260
type: SpeciesReference

259915
stoichiometry: 1.0
species: 405840
type: SpeciesReference

408639
kinetic law: 262848
product: 262836
product: 262824
reactant: 262812
fast: false
reversible: false
type: Reaction

266890
stoichiometry: 1.0
species: 405540
type: SpeciesReference

273046
stoichiometry: 1.0
species: 404280
type: SpeciesReference

271309
stoichiometry: 1.0
species: 404300
type: SpeciesReference

271671
stoichiometry: 1.0
species: 405680
type: SpeciesReference

269484
local parameters: 207958
local parameters: 207956
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

208037
units: 257862
value: 4.5359838E-16
type: LocalParameter

267660
stoichiometry: 1.0
species: 403240
type: SpeciesReference

401740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

267555
stoichiometry: 1.0
species: 403220
type: SpeciesReference

262680
stoichiometry: 1.0
species: 401880
type: SpeciesReference

401280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700
type: Species

260303
stoichiometry: 1.0
species: 404180
type: SpeciesReference

273659
stoichiometry: 1.0
species: 404780
type: SpeciesReference

268068
stoichiometry: 1.0
species: 403180
type: SpeciesReference

403580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

263904
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208237
units: 257775
value: 2.5E-17
type: LocalParameter

207522
units: 257862
value: 2.77776E-19
type: LocalParameter

207466
units: 257775
value: 8.0E-20
type: LocalParameter

273442
stoichiometry: 1.0
species: 404740
type: SpeciesReference

270196
stoichiometry: 1.0
species: 403180
type: SpeciesReference

265317
local parameters: 207743
local parameters: 207741
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

270764
stoichiometry: 1.0
species: 405620
type: SpeciesReference

207410
units: 257862
value: 4.86E-15
type: LocalParameter

260777
stoichiometry: 1.0
species: 400980
type: SpeciesReference

265293
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207463
units: 257862
value: 0.0
type: LocalParameter

275254
local parameters: 208257
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

268417
local parameters: 207903
local parameters: 207901
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

271067
stoichiometry: 1.0
species: 404020
type: SpeciesReference

258350
local parameters: 207358
local parameters: 207356
notes: kf*CaMKII_slash_CaMKII_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

208035
units: 257775
value: 9.0E-16
type: LocalParameter

272624
stoichiometry: 1.0
species: 404280
type: SpeciesReference

262896
local parameters: 207619
local parameters: 207617
notes: k1*PP1_PSD_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

400663
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

413479
kinetic law: 274711
product: 274699
reactant: 274687
reactant: 274675
fast: false
reversible: true
type: Reaction

269629
local parameters: 207964
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

271622
stoichiometry: 1.0
species: 404360
type: SpeciesReference

207359
units: 257862
value: 1.00002E-14
type: LocalParameter

257976
local parameters: 207334
local parameters: 207332
notes: kf*CaM_slash_CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

257823
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

263685
stoichiometry: 1.0
species: 402180
type: SpeciesReference

413259
kinetic law: 274180
product: 274168
product: 274156
reactant: 274144
fast: false
reversible: false
type: Reaction

275290
stoichiometry: 1.0
species: 405140
type: SpeciesReference

268453
stoichiometry: 1.0
species: 403180
type: SpeciesReference

259261
stoichiometry: 1.0
species: 404160
type: SpeciesReference

402620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207464
units: 257862
value: 1.08E-19
type: LocalParameter

272552
stoichiometry: 1.0
species: 405700
type: SpeciesReference

267744
local parameters: 207868
local parameters: 207866
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

207520
units: 257775
value: 5.0E-18
type: LocalParameter

262066
local parameters: 207575
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

260703
local parameters: 207506
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

274663
local parameters: 208227
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

260667
stoichiometry: 1.0
species: 400920
type: SpeciesReference

208239
units: 257862
value: 9.180054E-18
type: LocalParameter

270098
stoichiometry: 1.0
species: 403180
type: SpeciesReference

262824
stoichiometry: 1.0
species: 401860
type: SpeciesReference

410019
kinetic law: 266238
product: 266226
product: 266214
reactant: 266202
fast: false
reversible: false
type: Reaction

207358
units: 257775
value: 0.0
type: LocalParameter

207759
units: 257775
value: 1.8E-16
type: LocalParameter

267011
local parameters: 207829
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

268128
local parameters: 207888
local parameters: 207886
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

257751
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

258894
local parameters: 207394
local parameters: 207392
notes: kf*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaM_slash_CaM_minus_Ca4
type: KineticLaw

400980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

262005
stoichiometry: 1.0
species: 401380
type: SpeciesReference

261409
stoichiometry: 1.0
species: 406100
type: SpeciesReference

266926
stoichiometry: 1.0
species: 405800
type: SpeciesReference

266178
stoichiometry: 1.0
species: 402740
type: SpeciesReference

207605
units: 257775
value: 5.0E-18
type: LocalParameter

408479
kinetic law: 262453
product: 262441
product: 262429
reactant: 262417
fast: false
reversible: false
type: Reaction

271562
local parameters: 208065
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

264169
stoichiometry: 1.0
species: 402300
type: SpeciesReference

207819
units: 257775
value: 1.8E-16
type: LocalParameter

409579
kinetic law: 265173
product: 265161
product: 265149
reactant: 265136
fast: false
reversible: false
type: Reaction

406320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

411599
kinetic law: 270160
product: 270148
reactant: 270136
reactant: 270123
fast: false
reversible: true
type: Reaction

401300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

265209
stoichiometry: 1.0
species: 402520
type: SpeciesReference

412779
kinetic law: 273022
product: 273010
product: 272998
reactant: 272986
fast: false
reversible: false
type: Reaction

258749
stoichiometry: 1.0
species: 401600
type: SpeciesReference

207681
units: 257862
value: 3.420036E-18
type: LocalParameter

272660
stoichiometry: 1.0
species: 404280
type: SpeciesReference

272409
stoichiometry: 1.0
species: 405520
type: SpeciesReference

275026
stoichiometry: 1.0
species: 401520
type: SpeciesReference

403360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

263637
stoichiometry: 1.0
species: 404220
type: SpeciesReference

267480
stoichiometry: 1.0
species: 403180
type: SpeciesReference

267179
stoichiometry: 1.0
species: 405560
type: SpeciesReference

412839
kinetic law: 273166
product: 273154
reactant: 273142
reactant: 273130
fast: false
reversible: true
type: Reaction

258060
stoichiometry: 1.0
species: 401020
type: SpeciesReference

207567
units: 257862
value: 2.77776E-19
type: LocalParameter

260413
local parameters: 207491
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

207604
units: 257775
value: 2.0E-17
type: LocalParameter

207818
units: 257775
value: 7.2E-16
type: LocalParameter

207527
units: 257862
value: 2.77776E-19
type: LocalParameter

271417
local parameters: 208059
local parameters: 208057
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

401340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700
type: Species

267167
stoichiometry: 1.0
species: 402940
type: SpeciesReference

258688
stoichiometry: 1.0
species: 401740
type: SpeciesReference

408439
kinetic law: 262356
product: 262344
product: 262332
reactant: 262320
fast: false
reversible: false
type: Reaction

267300
local parameters: 207844
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

406000
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680
type: Species

273502
local parameters: 208167
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

403320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258531
stoichiometry: 1.0
species: 401540
type: SpeciesReference

207564
units: 257775
value: 2.0E-17
type: LocalParameter

262716
stoichiometry: 1.0
species: 401900
type: SpeciesReference

272515
stoichiometry: 1.0
species: 405680
type: SpeciesReference

405580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

407279
kinetic law: 259091
product: 259078
reactant: 259065
reactant: 259052
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1.
fast: false
reversible: true
type: Reaction

208039
units: 257775
value: 7.2E-15
type: LocalParameter

408939
kinetic law: 263576
product: 263564
reactant: 263552
reactant: 263540
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

271960
stoichiometry: 1.0
species: 405640
type: SpeciesReference

268526
stoichiometry: 1.0
species: 403420
type: SpeciesReference

269142
local parameters: 207939
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

410319
kinetic law: 266963
product: 266951
reactant: 266939
reactant: 266926
fast: false
reversible: true
type: Reaction

274555
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207683
units: 257775
value: 1.224E-16
type: LocalParameter

259804
stoichiometry: 1.0
species: 405440
type: SpeciesReference

262405
local parameters: 207594
local parameters: 207592
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

263222
stoichiometry: 1.0
species: 401980
type: SpeciesReference

274844
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207816
units: 257862
value: 2.011824E-17
type: LocalParameter

207602
units: 257862
value: 3.07998E-19
type: LocalParameter

405380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

269942
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207565
units: 257775
value: 5.0E-18
type: LocalParameter

272475
stoichiometry: 1.0
species: 404540
type: SpeciesReference

271816
stoichiometry: 1.0
species: 404400
type: SpeciesReference

207525
units: 257775
value: 5.0E-18
type: LocalParameter

410359
kinetic law: 267059
product: 267047
reactant: 267035
reactant: 267023
fast: false
reversible: true
type: Reaction

262788
stoichiometry: 1.0
species: 401920
type: SpeciesReference

270716
stoichiometry: 1.0
species: 403180
type: SpeciesReference

412039
kinetic law: 271225
product: 271213
reactant: 271201
reactant: 271189
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true
type: Reaction

260510
local parameters: 207496
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

207524
units: 257775
value: 2.0E-17
type: LocalParameter

409259
kinetic law: 264401
product: 264389
product: 264377
reactant: 264365
fast: false
reversible: false
type: Reaction

407060
kinetic law: 258447
product: 258435
reactant: 258423
reactant: 258410
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

267071
stoichiometry: 1.0
species: 402920
type: SpeciesReference

207684
units: 257775
value: 3.06E-17
type: LocalParameter

268562
local parameters: 207909
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

208079
units: 257775
value: 6.8E-18
type: LocalParameter

409199
kinetic law: 264254
product: 264242
reactant: 264229
reactant: 264217
fast: false
reversible: true
type: Reaction

259152
stoichiometry: 1.0
species: 403000
type: SpeciesReference

412079
kinetic law: 271321
product: 271309
reactant: 271297
reactant: 271285
fast: false
reversible: true
type: Reaction

266021
stoichiometry: 1.0
species: 405500
type: SpeciesReference

263210
stoichiometry: 1.0
species: 400760
type: SpeciesReference

264340
stoichiometry: 1.0
species: 402340
type: SpeciesReference

272938
stoichiometry: 1.0
species: 405780
type: SpeciesReference

265887
stoichiometry: 1.0
species: 402680
type: SpeciesReference

273611
stoichiometry: 1.0
species: 405720
type: SpeciesReference

268020
stoichiometry: 1.0
species: 403320
type: SpeciesReference

207791
units: 257862
value: 2.011824E-17
type: LocalParameter

407160
kinetic law: 258725
product: 258713
reactant: 258700
reactant: 258688
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

406080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700
type: Species

259369
stoichiometry: 1.0
species: 403100
type: SpeciesReference

266963
local parameters: 207828
local parameters: 207826
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

207753
units: 257775
value: 7.2E-16
type: LocalParameter

207600
units: 257775
value: 6.0E-17
type: LocalParameter

207418
units: 257775
value: 9.9E-15
type: LocalParameter

411319
kinetic law: 269484
product: 269472
reactant: 269460
reactant: 269448
fast: false
reversible: true
type: Reaction

264013
local parameters: 207674
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

264944
stoichiometry: 1.0
species: 402460
type: SpeciesReference

270317
stoichiometry: 1.0
species: 405540
type: SpeciesReference

407559
kinetic law: 260168
product: 260156
reactant: 260144
reactant: 260131
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true
type: Reaction

207713
units: 257775
value: 7.2E-16
type: LocalParameter

412979
kinetic law: 273502
product: 273490
product: 273478
reactant: 273466
fast: false
reversible: false
type: Reaction

410899
kinetic law: 268417
product: 268405
reactant: 268393
reactant: 268382
fast: false
reversible: true
type: Reaction

270994
stoichiometry: 1.0
species: 404160
type: SpeciesReference

411299
kinetic law: 269436
product: 269423
product: 269411
reactant: 269399
fast: false
reversible: false
type: Reaction

406040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680
type: Species

411359
kinetic law: 269580
product: 269568
reactant: 269556
reactant: 269544
fast: false
reversible: true
type: Reaction

273106
stoichiometry: 1.0
species: 404280
type: SpeciesReference

264680
stoichiometry: 1.0
species: 402200
type: SpeciesReference

404400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207814
units: 257775
value: 1.8E-16
type: LocalParameter

407599
kinetic law: 260241
product: 260228
reactant: 260216
fast: false
reversible: true
type: Reaction

271732
stoichiometry: 1.0
species: 405640
type: SpeciesReference

265547
stoichiometry: 1.0
species: 402200
type: SpeciesReference

403660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207419
units: 257862
value: 6.750054E-15
type: LocalParameter

274446
stoichiometry: 1.0
species: 405760
type: SpeciesReference

259878
local parameters: 207457
local parameters: 207455
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*AMPAR_memb_slash_Anchor
type: KineticLaw

273382
stoichiometry: 1.0
species: 405620
type: SpeciesReference

265245
stoichiometry: 1.0
species: 405360
type: SpeciesReference

207714
units: 257775
value: 1.8E-16
type: LocalParameter

407120
kinetic law: 258580
product: 258568
reactant: 258556
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

266069
stoichiometry: 1.0
species: 402200
type: SpeciesReference

259200
stoichiometry: 1.0
species: 403020
type: SpeciesReference

269203
stoichiometry: 1.0
species: 403560
type: SpeciesReference

207793
units: 257775
value: 7.2E-16
type: LocalParameter

403980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 400680
type: Species

261652
stoichiometry: 1.0
species: 405540
type: SpeciesReference

404480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

268887
stoichiometry: 1.0
species: 403500
type: SpeciesReference

274518
local parameters: 208221
local parameters: 208219
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

404780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

269556
stoichiometry: 1.0
species: 403180
type: SpeciesReference

271852
local parameters: 208080
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

265937
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207813
units: 257775
value: 7.2E-16
type: LocalParameter

404120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

408079
kinetic law: 261385
product: 261373
product: 261361
reactant: 261348
fast: false
reversible: false
type: Reaction

271140
stoichiometry: 1.0
species: 404080
type: SpeciesReference

260131
stoichiometry: 1.0
species: 405280
type: SpeciesReference

207569
units: 257775
value: 2.0E-17
type: LocalParameter

207751
units: 257862
value: 1.8106416E-16
type: LocalParameter

207416
units: 257862
value: 6.750054E-15
type: LocalParameter

412619
kinetic law: 272636
product: 272624
product: 272612
reactant: 272600
fast: false
reversible: false
type: Reaction

208232
units: 257775
value: 3.5E-18
type: LocalParameter

258133
stoichiometry: 1.0
species: 400780
type: SpeciesReference

264303
local parameters: 207689
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

271453
stoichiometry: 1.0
species: 404280
type: SpeciesReference

261433
local parameters: 207544
local parameters: 207542
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

207711
units: 257862
value: 1.8106416E-16
type: LocalParameter

207529
units: 257775
value: 2.0E-17
type: LocalParameter

402940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270957
stoichiometry: 1.0
species: 403960
type: SpeciesReference

404160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

407519
kinetic law: 260071
product: 260059
reactant: 260047
reactant: 260035
fast: false
reversible: true
type: Reaction

405220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208231
units: 257775
value: 1.4E-17
type: LocalParameter

265149
stoichiometry: 1.0
species: 405480
type: SpeciesReference

412939
kinetic law: 273406
product: 273394
product: 273382
reactant: 273370
fast: false
reversible: false
type: Reaction

274398
stoichiometry: 1.0
species: 404280
type: SpeciesReference

404440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

270038
stoichiometry: 1.0
species: 403180
type: SpeciesReference

272298
stoichiometry: 1.0
species: 404500
type: SpeciesReference

401400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

260180
stoichiometry: 1.0
species: 405820
type: SpeciesReference

208085
units: 257775
value: 1.7E-18
type: LocalParameter

207706
units: 257862
value: 1.8106416E-16
type: LocalParameter

261373
stoichiometry: 1.0
species: 406100
type: SpeciesReference

404220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

402120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207821
units: 257862
value: 2.011824E-17
type: LocalParameter

412299
kinetic law: 271852
product: 271840
product: 271828
reactant: 271816
fast: false
reversible: false
type: Reaction

259999
stoichiometry: 1.0
species: 405840
type: SpeciesReference

273599
local parameters: 208172
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

263854
stoichiometry: 1.0
species: 402240
type: SpeciesReference

266407
stoichiometry: 1.0
species: 405520
type: SpeciesReference

407739
kinetic law: 260558
product: 260546
reactant: 260534
reactant: 260522
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

263492
stoichiometry: 1.0
species: 402080
type: SpeciesReference

264848
stoichiometry: 1.0
species: 402440
type: SpeciesReference

260558
local parameters: 207500
local parameters: 207498
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

267384
stoichiometry: 1.0
species: 402200
type: SpeciesReference

272721
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207794
units: 257775
value: 1.8E-16
type: LocalParameter

263198
stoichiometry: 1.0
species: 402020
type: SpeciesReference

259951
stoichiometry: 1.0
species: 405180
type: SpeciesReference

261262
stoichiometry: 1.0
species: 405520
type: SpeciesReference

261506
stoichiometry: 1.0
species: 406100
type: SpeciesReference

268742
stoichiometry: 1.0
species: 403180
type: SpeciesReference

266732
stoichiometry: 1.0
species: 405720
type: SpeciesReference

410999
kinetic law: 268658
product: 268646
product: 268634
reactant: 268622
fast: false
reversible: false
type: Reaction

269666
stoichiometry: 1.0
species: 403660
type: SpeciesReference

208021
units: 257862
value: 3.999888E-17
type: LocalParameter

274760
local parameters: 208232
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

269738
stoichiometry: 1.0
species: 405600
type: SpeciesReference

207689
units: 257775
value: 1.8E-16
type: LocalParameter

408899
kinetic law: 263480
product: 263467
reactant: 263455
reactant: 263443
fast: false
reversible: true
type: Reaction

263940
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207823
units: 257775
value: 7.2E-16
type: LocalParameter

269032
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274494
stoichiometry: 1.0
species: 404280
type: SpeciesReference

264620
stoichiometry: 1.0
species: 402200
type: SpeciesReference

264572
stoichiometry: 1.0
species: 405440
type: SpeciesReference

207861
units: 257862
value: 5.99994E-17
type: LocalParameter

402240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

402880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

273794
local parameters: 208182
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

274011
stoichiometry: 1.0
species: 404280
type: SpeciesReference

266202
stoichiometry: 1.0
species: 402740
type: SpeciesReference

207704
units: 257775
value: 1.8E-16
type: LocalParameter

260291
stoichiometry: 1.0
species: 405960
type: SpeciesReference

271177
local parameters: 208045
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

260595
stoichiometry: 1.0
species: 406000
type: SpeciesReference

265985
stoichiometry: 1.0
species: 402700
type: SpeciesReference

263005
stoichiometry: 1.0
species: 401960
type: SpeciesReference

265185
stoichiometry: 1.0
species: 405320
type: SpeciesReference

258700
stoichiometry: 1.0
species: 404180
type: SpeciesReference

207796
units: 257862
value: 2.011824E-17
type: LocalParameter

410679
kinetic law: 267888
product: 267876
product: 267864
reactant: 267852
fast: false
reversible: false
type: Reaction

402160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

406160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208084
units: 257775
value: 6.8E-18
type: LocalParameter

273070
local parameters: 208146
local parameters: 208143
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

401180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700
type: Species

207703
units: 257775
value: 7.2E-16
type: LocalParameter

264740
local parameters: 207713
local parameters: 207711
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

268851
local parameters: 207924
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

267996
stoichiometry: 1.0
species: 405440
type: SpeciesReference

406100
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700
type: Species

273262
local parameters: 208156
local parameters: 208154
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

259501
stoichiometry: 1.0
species: 402640
type: SpeciesReference

400940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

401820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

405680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

208089
units: 257775
value: 6.8E-18
type: LocalParameter

208026
units: 257775
value: 4.05E-16
type: LocalParameter

267900
stoichiometry: 1.0
species: 405400
type: SpeciesReference

267780
stoichiometry: 1.0
species: 403180
type: SpeciesReference

263430
local parameters: 207645
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

404380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207686
units: 257862
value: 1.8106416E-16
type: LocalParameter

409479
kinetic law: 264932
product: 264920
reactant: 264908
reactant: 264896
fast: false
reversible: true
type: Reaction

207646
units: 257862
value: 2.2062942E-16
type: LocalParameter

404820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

270837
local parameters: 208028
local parameters: 208026
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

412119
kinetic law: 271417
product: 271405
reactant: 271393
reactant: 271381
fast: false
reversible: true
type: Reaction

267276
stoichiometry: 1.0
species: 405560
type: SpeciesReference

411419
kinetic law: 269726
product: 269714
product: 269702
reactant: 269690
fast: false
reversible: false
type: Reaction

402660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

266286
local parameters: 207793
local parameters: 207791
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

207798
units: 257775
value: 7.2E-16
type: LocalParameter

258858
local parameters: 207391
local parameters: 207389
notes: kf*CaM_slash_CaM_minus_Ca3*Ca-kb*CaM_slash_CaM_minus_Ca4
type: KineticLaw

258785
stoichiometry: 1.0
species: 401660
type: SpeciesReference

207645
units: 257775
value: 2.25E-16
type: LocalParameter

412219
kinetic law: 271659
product: 271647
product: 271634
reactant: 271622
fast: false
reversible: false
type: Reaction

402720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

273719
stoichiometry: 1.0
species: 404280
type: SpeciesReference

406860
kinetic law: 257976
product: 257964
reactant: 257952
reactant: 257939
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

401640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 400700
type: Species

207709
units: 257775
value: 1.8E-16
type: LocalParameter

207971
units: 257862
value: 3.999888E-17
type: LocalParameter

263089
local parameters: 207629
local parameters: 207627
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

264462
stoichiometry: 1.0
species: 402360
type: SpeciesReference

208138
units: 257862
value: 8.7498E-18
type: LocalParameter

272878
local parameters: 208135
local parameters: 208133
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

270257
local parameters: 207998
local parameters: 207996
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

401680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258797
stoichiometry: 1.0
species: 401640
type: SpeciesReference

273756
stoichiometry: 1.0
species: 404800
type: SpeciesReference

269870
local parameters: 207978
local parameters: 207976
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

265766
stoichiometry: 1.0
species: 405680
type: SpeciesReference

267888
local parameters: 207874
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

267595
local parameters: 207859
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

207799
units: 257775
value: 1.8E-16
type: LocalParameter

263745
stoichiometry: 1.0
species: 402200
type: SpeciesReference

412159
kinetic law: 271514
product: 271502
reactant: 271489
reactant: 271477
fast: false
reversible: true
type: Reaction

207562
units: 257862
value: 2.77776E-19
type: LocalParameter

413719
kinetic law: 275302
product: 275290
reactant: 275278
reactant: 275266
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

404020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

262563
stoichiometry: 1.0
species: 401060
type: SpeciesReference

403540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

411739
kinetic law: 270498
product: 270486
product: 270474
reactant: 270462
fast: false
reversible: false
type: Reaction

266443
stoichiometry: 1.0
species: 405600
type: SpeciesReference

405640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207688
units: 257775
value: 7.2E-16
type: LocalParameter

208024
units: 257775
value: 5.4E-16
type: LocalParameter

207708
units: 257775
value: 7.2E-16
type: LocalParameter

208087
units: 257862
value: 8.7498E-18
type: LocalParameter

261833
stoichiometry: 1.0
species: 401340
type: SpeciesReference

262752
local parameters: 207610
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

207648
units: 257775
value: 9.0E-16
type: LocalParameter

412519
kinetic law: 272383
product: 272371
reactant: 272358
reactant: 272346
fast: false
reversible: true
type: Reaction

263320
stoichiometry: 1.0
species: 401980
type: SpeciesReference

259599
local parameters: 207439
local parameters: 207437
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE
type: KineticLaw

411079
kinetic law: 268851
product: 268839
product: 268826
reactant: 268814
fast: false
reversible: false
type: Reaction

403080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

263113
stoichiometry: 1.0
species: 400780
type: SpeciesReference

411039
kinetic law: 268754
product: 268742
product: 268730
reactant: 268718
fast: false
reversible: false
type: Reaction

262453
local parameters: 207595
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

262526
stoichiometry: 1.0
species: 400980
type: SpeciesReference

208136
units: 257775
value: 1.7E-18
type: LocalParameter

208023
units: 257775
value: 2.16E-15
type: LocalParameter

265475
stoichiometry: 1.0
species: 405300
type: SpeciesReference

411779
kinetic law: 270595
product: 270583
product: 270570
reactant: 270558
fast: false
reversible: false
type: Reaction

271634
stoichiometry: 1.0
species: 400960
type: SpeciesReference

268357
stoichiometry: 1.0
species: 403180
type: SpeciesReference

258580
local parameters: 207373
local parameters: 207371
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin
type: KineticLaw

207398
units: 257775
value: 9.0E-17
type: LocalParameter

207649
units: 257775
value: 2.25E-16
type: LocalParameter

412559
kinetic law: 272488
product: 272475
reactant: 272462
reactant: 272449
fast: false
reversible: true
type: Reaction

405600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207560
units: 257775
value: 5.0E-18
type: LocalParameter

271249
stoichiometry: 1.0
species: 403960
type: SpeciesReference

402460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

264389
stoichiometry: 1.0
species: 402200
type: SpeciesReference

413299
kinetic law: 274276
product: 274264
product: 274252
reactant: 274240
fast: false
reversible: false
type: Reaction

261214
stoichiometry: 1.0
species: 406100
type: SpeciesReference

269774
local parameters: 207973
local parameters: 207971
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

264425
stoichiometry: 1.0
species: 402200
type: SpeciesReference

258410
stoichiometry: 1.0
species: 401520
type: SpeciesReference

407380
kinetic law: 259599
product: 259586
reactant: 259573
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true
type: Reaction

268814
stoichiometry: 1.0
species: 403480
type: SpeciesReference

207356
units: 257862
value: 4.99998E-16
type: LocalParameter

407020
kinetic law: 258350
product: 258338
reactant: 258326
reactant: 258314
fast: false
reversible: true
type: Reaction

273550
local parameters: 208171
local parameters: 208169
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

400760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 400680
type: Species

412879
kinetic law: 273262
product: 273250
reactant: 273238
reactant: 273226
fast: false
reversible: true
type: Reaction

266551
stoichiometry: 1.0
species: 402200
type: SpeciesReference

272189
local parameters: 208099
local parameters: 208097
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

261104
stoichiometry: 1.0
species: 405580
type: SpeciesReference

265656
local parameters: 207759
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

268176
local parameters: 207889
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

274917
stoichiometry: 1.0
species: 405060
type: SpeciesReference

270353
local parameters: 208003
local parameters: 208001
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

264908
stoichiometry: 1.0
species: 402200
type: SpeciesReference

260923
stoichiometry: 1.0
species: 406100
type: SpeciesReference

262969
stoichiometry: 1.0
species: 401880
type: SpeciesReference

409719
kinetic law: 265511
product: 265499
reactant: 265487
reactant: 265475
fast: false
reversible: true
type: Reaction

264668
stoichiometry: 1.0
species: 405180
type: SpeciesReference

207397
units: 257775
value: 9.0E-18
type: LocalParameter

208135
units: 257775
value: 6.8E-18
type: LocalParameter

207974
units: 257775
value: 5.4E-16
type: LocalParameter

403720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272449
stoichiometry: 1.0
species: 405760
type: SpeciesReference

262126
stoichiometry: 1.0
species: 401400
type: SpeciesReference

405440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258012
stoichiometry: 1.0
species: 400800
type: SpeciesReference

275170
stoichiometry: 1.0
species: 401640
type: SpeciesReference

405480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207976
units: 257862
value: 3.999888E-17
type: LocalParameter

274954
local parameters: 208242
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

408400
kinetic law: 262260
product: 262248
product: 262236
reactant: 262223
fast: false
reversible: false
type: Reaction

403760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207642
units: 257862
value: 2.2062942E-16
type: LocalParameter

260011
stoichiometry: 1.0
species: 405800
type: SpeciesReference

264800
stoichiometry: 1.0
species: 405360
type: SpeciesReference

270148
stoichiometry: 1.0
species: 403760
type: SpeciesReference

207469
units: 257775
value: 8.0E-20
type: LocalParameter

413539
kinetic law: 274856
product: 274844
product: 274832
reactant: 274820
fast: false
reversible: false
type: Reaction

273154
stoichiometry: 1.0
species: 404680
type: SpeciesReference

208029
units: 257775
value: 1.8E-16
type: LocalParameter

269592
stoichiometry: 1.0
species: 403640
type: SpeciesReference

259016
stoichiometry: 1.0
species: 402120
type: SpeciesReference

412499
kinetic law: 272334
product: 272322
product: 272310
reactant: 272298
fast: false
reversible: false
type: Reaction

264788
local parameters: 207714
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

260813
stoichiometry: 1.0
species: 401060
type: SpeciesReference

407439
kinetic law: 259780
product: 259768
reactant: 259756
reactant: 259744
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

207643
units: 257775
value: 9.0E-16
type: LocalParameter

271019
stoichiometry: 1.0
species: 404040
type: SpeciesReference

400720
constant: true
size: 5.0E-15
spatial dimensions: 3.0
type: Compartment

268200
stoichiometry: 1.0
species: 403180
type: SpeciesReference

272249
stoichiometry: 1.0
species: 405700
type: SpeciesReference

411479
kinetic law: 269870
product: 269858
reactant: 269846
reactant: 269834
fast: false
reversible: true
type: Reaction

207869
units: 257775
value: 5.4E-16
type: LocalParameter

263794
stoichiometry: 1.0
species: 401580
type: SpeciesReference

261616
stoichiometry: 1.0
species: 401300
type: SpeciesReference

208028
units: 257739
value: 299.9976000192
type: LocalParameter

259549
stoichiometry: 1.0
species: 403940
type: SpeciesReference

270885
local parameters: 208031
local parameters: 208029
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

208133
units: 257862
value: 8.7498E-18
type: LocalParameter

408979
kinetic law: 263721
product: 263709
product: 263697
reactant: 263685
fast: false
reversible: false
type: Reaction

207395
units: 257862
value: 4.4998254E-14
type: LocalParameter

273490
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207355
units: 257862
value: 0.0
type: LocalParameter

409159
kinetic law: 264157
product: 264145
reactant: 264133
reactant: 264121
fast: false
reversible: true
type: Reaction

407620
kinetic law: 260278
product: 260266
reactant: 260254
fast: false
reversible: true
type: Reaction

403020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

274059
stoichiometry: 1.0
species: 405780
type: SpeciesReference

257901
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

262018
local parameters: 207574
local parameters: 207572
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

268923
stoichiometry: 1.0
species: 405280
type: SpeciesReference

261761
stoichiometry: 1.0
species: 406100
type: SpeciesReference

273867
stoichiometry: 1.0
species: 405580
type: SpeciesReference

207868
units: 257775
value: 2.16E-15
type: LocalParameter

207467
units: 257862
value: 1.08E-19
type: LocalParameter

405060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 400680
type: Species

262860
stoichiometry: 1.0
species: 404220
type: SpeciesReference

403820
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258302
local parameters: 207355
local parameters: 207353
notes: kf*CaMKII_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD*CaMKII_slash_CaMKII_minus_PSD
type: KineticLaw

207973
units: 257775
value: 2.16E-15
type: LocalParameter

207394
units: 257775
value: 5.4E-15
type: LocalParameter

408579
kinetic law: 262704
product: 262692
reactant: 262680
reactant: 262667
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

265584
stoichiometry: 1.0
species: 402200
type: SpeciesReference

274095
stoichiometry: 1.0
species: 405740
type: SpeciesReference

259052
stoichiometry: 1.0
species: 402100
type: SpeciesReference

266130
stoichiometry: 1.0
species: 402200
type: SpeciesReference

265692
stoichiometry: 1.0
species: 402620
type: SpeciesReference

272830
local parameters: 208131
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

207979
units: 257775
value: 5.4E-16
type: LocalParameter

207352
units: 257775
value: 1.0E-17
type: LocalParameter

270546
local parameters: 208013
local parameters: 208011
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

208042
units: 257862
value: 1.8900054E-17
type: LocalParameter

409899
kinetic law: 265949
product: 265937
product: 265925
reactant: 265913
fast: false
reversible: false
type: Reaction

408159
kinetic law: 261628
product: 261616
reactant: 261604
reactant: 261592
fast: false
reversible: true
type: Reaction

269301
stoichiometry: 1.0
species: 403580
type: SpeciesReference

410179
kinetic law: 266623
product: 266611
product: 266599
reactant: 266587
fast: false
reversible: false
type: Reaction

270607
stoichiometry: 1.0
species: 405560
type: SpeciesReference

274990
stoichiometry: 1.0
species: 405080
type: SpeciesReference

267840
local parameters: 207873
local parameters: 207871
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

265838
stoichiometry: 1.0
species: 402200
type: SpeciesReference

271526
stoichiometry: 1.0
species: 404340
type: SpeciesReference

208131
units: 257775
value: 3.5E-18
type: LocalParameter

257799
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

261154
stoichiometry: 1.0
species: 401200
type: SpeciesReference

261482
local parameters: 207545
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

402300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413699
kinetic law: 275254
product: 275242
product: 275230
reactant: 275218
fast: false
reversible: false
type: Reaction

264278
stoichiometry: 1.0
species: 405180
type: SpeciesReference

259612
stoichiometry: 1.0
species: 404060
type: SpeciesReference

259841
stoichiometry: 1.0
species: 405540
type: SpeciesReference

405520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

258398
local parameters: 207361
local parameters: 207359
notes: kf*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

269251
stoichiometry: 1.0
species: 405640
type: SpeciesReference

413039
kinetic law: 273647
product: 273635
reactant: 273623
reactant: 273611
fast: false
reversible: true
type: Reaction

408819
kinetic law: 263284
product: 263272
reactant: 263259
reactant: 263247
fast: false
reversible: true
type: Reaction

274385
stoichiometry: 1.0
species: 405800
type: SpeciesReference

207353
units: 257775
value: 5.0E-17
type: LocalParameter

267948
stoichiometry: 1.0
species: 403300
type: SpeciesReference

271924
stoichiometry: 1.0
species: 405500
type: SpeciesReference

207392
units: 257775
value: 5.4E-15
type: LocalParameter

268285
stoichiometry: 1.0
species: 405400
type: SpeciesReference

266515
stoichiometry: 1.0
species: 402200
type: SpeciesReference

404280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 400700
type: Species

270462
stoichiometry: 1.0
species: 403820
type: SpeciesReference

208082
units: 257862
value: 8.7498E-18
type: LocalParameter

273214
local parameters: 208152
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

259429
local parameters: 207427
local parameters: 207425
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4
type: KineticLaw

259091
local parameters: 207406
local parameters: 207404
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

208130
units: 257775
value: 1.4E-17
type: LocalParameter

261725
local parameters: 207559
local parameters: 207557
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

207866
units: 257862
value: 3.5998992E-16
type: LocalParameter

266623
local parameters: 207809
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

413079
kinetic law: 273744
product: 273731
reactant: 273719
reactant: 273707
fast: false
reversible: true
type: Reaction

266491
stoichiometry: 1.0
species: 402800
type: SpeciesReference

207350
units: 257775
value: 1.0E-17
type: LocalParameter

207864
units: 257775
value: 8.1E-16
type: LocalParameter

258459
stoichiometry: 1.0
species: 401680
type: SpeciesReference

275134
stoichiometry: 1.0
species: 403920
type: SpeciesReference

208040
units: 257775
value: 1.8E-15
type: LocalParameter

271201
stoichiometry: 1.0
species: 404100
type: SpeciesReference

261190
local parameters: 207530
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

264896
stoichiometry: 1.0
species: 405380
type: SpeciesReference

271393
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207391
units: 257775
value: 9.0E-16
type: LocalParameter

408219
kinetic law: 261773
product: 261761
product: 261749
reactant: 261737
fast: false
reversible: false
type: Reaction

265076
local parameters: 207729
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

401560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272334
local parameters: 208105
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

404740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

268634
stoichiometry: 1.0
species: 405300
type: SpeciesReference

274168
stoichiometry: 1.0
species: 404280
type: SpeciesReference

266359
stoichiometry: 1.0
species: 402200
type: SpeciesReference

262284
stoichiometry: 1.0
species: 406100
type: SpeciesReference

267444
local parameters: 207853
local parameters: 207851
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

263528
local parameters: 207649
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

273975
stoichiometry: 1.0
species: 404280
type: SpeciesReference

260983
stoichiometry: 1.0
species: 406100
type: SpeciesReference

208080
units: 257775
value: 1.7E-18
type: LocalParameter

207640
units: 257775
value: 2.25E-16
type: LocalParameter

274808
local parameters: 208236
local parameters: 208234
notes: k1*CaMKII_slash_CaMKII_minus_thr305_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

207863
units: 257775
value: 3.24E-15
type: LocalParameter

272032
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207978
units: 257775
value: 2.16E-15
type: LocalParameter

272371
stoichiometry: 1.0
species: 404520
type: SpeciesReference

411259
kinetic law: 269338
product: 269326
product: 269314
reactant: 269301
fast: false
reversible: false
type: Reaction

407320
kinetic law: 259333
product: 259321
reactant: 259309
reactant: 259297
fast: false
reversible: true
type: Reaction

262272
stoichiometry: 1.0
species: 405600
type: SpeciesReference

275062
local parameters: 208247
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

265728
stoichiometry: 1.0
species: 405460
type: SpeciesReference

269326
stoichiometry: 1.0
species: 403180
type: SpeciesReference

408859
kinetic law: 263381
product: 263368
reactant: 263356
reactant: 263344
fast: false
reversible: true
type: Reaction

271285
stoichiometry: 1.0
species: 401080
type: SpeciesReference

266503
stoichiometry: 1.0
species: 405520
type: SpeciesReference

207724
units: 257775
value: 1.8E-16
type: LocalParameter

207938
units: 257775
value: 2.16E-15
type: LocalParameter

257964
stoichiometry: 1.0
species: 400780
type: SpeciesReference

207443
units: 257775
value: 2.7E-14
type: LocalParameter

403700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

259417
stoichiometry: 1.0
species: 403120
type: SpeciesReference

270026
stoichiometry: 1.0
species: 405720
type: SpeciesReference

263673
local parameters: 207658
local parameters: 207656
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

409939
kinetic law: 266045
product: 266033
product: 266021
reactant: 266009
fast: false
reversible: false
type: Reaction

260144
stoichiometry: 1.0
species: 405840
type: SpeciesReference

272636
local parameters: 208121
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

266659
stoichiometry: 1.0
species: 402840
type: SpeciesReference

208229
units: 257862
value: 8.7498E-18
type: LocalParameter

407240
kinetic law: 258943
product: 258930
reactant: 258918
reactant: 258906
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

403100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207475
units: 257775
value: 8.0E-20
type: LocalParameter

275266
stoichiometry: 1.0
species: 401620
type: SpeciesReference

272080
stoichiometry: 1.0
species: 404460
type: SpeciesReference

266914
local parameters: 207824
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

267023
stoichiometry: 1.0
species: 405800
type: SpeciesReference

207723
units: 257775
value: 7.2E-16
type: LocalParameter

403200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258145
stoichiometry: 1.0
species: 401020
type: SpeciesReference

407280
kinetic law: 259140
product: 259127
reactant: 259115
reactant: 259103
fast: false
reversible: true
type: Reaction

262836
stoichiometry: 1.0
species: 401880
type: SpeciesReference

207404
units: 257811
value: 9.00720324E-13
type: LocalParameter

258290
stoichiometry: 1.0
species: 401000
type: SpeciesReference

208109
units: 257775
value: 6.8E-18
type: LocalParameter

207476
units: 257775
value: 3.5E-21
type: LocalParameter

271840
stoichiometry: 1.0
species: 404280
type: SpeciesReference

260631
stoichiometry: 1.0
species: 406000
type: SpeciesReference

207403
units: 257775
value: 9.0E-17
type: LocalParameter

269288
local parameters: 207948
local parameters: 207946
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

274675
stoichiometry: 1.0
species: 405560
type: SpeciesReference

412659
kinetic law: 272733
product: 272721
product: 272709
reactant: 272697
fast: false
reversible: false
type: Reaction

208227
units: 257775
value: 3.5E-18
type: LocalParameter

411959
kinetic law: 271031
product: 271019
reactant: 271006
reactant: 270994
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true
type: Reaction

261640
stoichiometry: 1.0
species: 401300
type: SpeciesReference

208171
units: 257775
value: 6.8E-18
type: LocalParameter

259273
stoichiometry: 1.0
species: 403060
type: SpeciesReference

268393
stoichiometry: 1.0
species: 403180
type: SpeciesReference

263368
stoichiometry: 1.0
species: 402060
type: SpeciesReference

269239
local parameters: 207944
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

207445
units: 257775
value: 2.7E-14
type: LocalParameter

266057
stoichiometry: 1.0
species: 405580
type: SpeciesReference

207726
units: 257862
value: 1.8106416E-16
type: LocalParameter

273034
stoichiometry: 1.0
species: 405720
type: SpeciesReference

403280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

262993
local parameters: 207624
local parameters: 207622
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

207407
units: 257862
value: 5.399946E-14
type: LocalParameter

265088
stoichiometry: 1.0
species: 405300
type: SpeciesReference

208226
units: 257775
value: 1.4E-17
type: LocalParameter

207511
units: 257775
value: 6.0E-17
type: LocalParameter

266696
stoichiometry: 1.0
species: 405660
type: SpeciesReference

272044
local parameters: 208090
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

265511
local parameters: 207753
local parameters: 207751
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

273987
local parameters: 208192
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

263516
stoichiometry: 1.0
species: 401980
type: SpeciesReference

401220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

258604
stoichiometry: 2.0
species: 404180
type: SpeciesReference

207446
units: 257775
value: 1.0E-17
type: LocalParameter

408199
kinetic law: 261725
product: 261712
reactant: 261700
reactant: 261688
fast: false
reversible: true
type: Reaction

404880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

270752
stoichiometry: 1.0
species: 403880
type: SpeciesReference

408319
kinetic law: 262018
product: 262005
reactant: 261993
reactant: 261980
fast: false
reversible: true
type: Reaction

272902
stoichiometry: 1.0
species: 405720
type: SpeciesReference

207939
units: 257775
value: 5.4E-16
type: LocalParameter

400780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

260789
stoichiometry: 1.0
species: 406060
type: SpeciesReference

264025
stoichiometry: 1.0
species: 404220
type: SpeciesReference

401920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 400680
type: Species

207406
units: 257775
value: 9.0E-17
type: LocalParameter

264932
local parameters: 207723
local parameters: 207721
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

411879
kinetic law: 270837
modifier: 270825
product: 270812
reactant: 270800
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false
type: Reaction

270184
stoichiometry: 1.0
species: 405780
type: SpeciesReference

408359
kinetic law: 262114
product: 262102
reactant: 262090
reactant: 262078
fast: false
reversible: true
type: Reaction

207510
units: 257775
value: 2.4E-16
type: LocalParameter

410839
kinetic law: 268273
product: 268261
product: 268249
reactant: 268237
fast: false
reversible: false
type: Reaction

267696
local parameters: 207864
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

207478
units: 257775
value: 1.26E-19
type: LocalParameter

403240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

273647
local parameters: 208176
local parameters: 208174
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

268032
local parameters: 207883
local parameters: 207881
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

208067
units: 257862
value: 6.2502E-17
type: LocalParameter

261531
local parameters: 207549
local parameters: 207547
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

207409
units: 257775
value: 9.0E-17
type: LocalParameter

407200
kinetic law: 258858
product: 258845
reactant: 258833
reactant: 258821
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

259164
stoichiometry: 1.0
species: 404160
type: SpeciesReference

262615
stoichiometry: 1.0
species: 401500
type: SpeciesReference

274639
stoichiometry: 1.0
species: 405600
type: SpeciesReference

410499
kinetic law: 267396
product: 267384
product: 267372
reactant: 267360
fast: false
reversible: false
type: Reaction

267647
local parameters: 207863
local parameters: 207861
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

261311
stoichiometry: 1.0
species: 406100
type: SpeciesReference

271333
stoichiometry: 1.0
species: 404300
type: SpeciesReference

207934
units: 257775
value: 5.4E-16
type: LocalParameter

411239
kinetic law: 269288
product: 269276
reactant: 269263
reactant: 269251
fast: false
reversible: true
type: Reaction

262163
local parameters: 207580
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

271261
stoichiometry: 1.0
species: 404100
type: SpeciesReference

264073
stoichiometry: 1.0
species: 402280
type: SpeciesReference

207448
units: 257862
value: 0.0
type: LocalParameter

407919
kinetic law: 260995
product: 260983
product: 260971
reactant: 260959
fast: false
reversible: false
type: Reaction

258930
stoichiometry: 1.0
species: 401840
type: SpeciesReference

409299
kinetic law: 264498
product: 264486
product: 264474
reactant: 264462
fast: false
reversible: false
type: Reaction

403060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208174
units: 257862
value: 8.7498E-18
type: LocalParameter

411139
kinetic law: 269044
product: 269032
product: 269020
reactant: 269007
fast: false
reversible: false
type: Reaction

208224
units: 257862
value: 8.7498E-18
type: LocalParameter

404560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

409119
kinetic law: 264061
product: 264049
reactant: 264037
reactant: 264025
fast: false
reversible: true
type: Reaction

260107
stoichiometry: 1.0
species: 405760
type: SpeciesReference

272152
stoichiometry: 1.0
species: 405760
type: SpeciesReference

258254
local parameters: 207352
local parameters: 207350
notes: kf*CaMKII_slash_basal_CaMKII_PSD_control-kb*CaMKII_slash_basal_CaMKII_PSD
type: KineticLaw

272358
stoichiometry: 1.0
species: 404280
type: SpeciesReference

273346
stoichiometry: 1.0
species: 404720
type: SpeciesReference

262417
stoichiometry: 1.0
species: 401460
type: SpeciesReference

407959
kinetic law: 261092
product: 261080
product: 261068
reactant: 261056
fast: false
reversible: false
type: Reaction

268309
stoichiometry: 1.0
species: 403380
type: SpeciesReference

403860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

271996
local parameters: 208089
local parameters: 208087
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

262393
stoichiometry: 1.0
species: 401460
type: SpeciesReference

404660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

401960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 400680
type: Species

207933
units: 257775
value: 2.16E-15
type: LocalParameter

262728
stoichiometry: 1.0
species: 401800
type: SpeciesReference

273903
stoichiometry: 1.0
species: 405540
type: SpeciesReference

410459
kinetic law: 267300
product: 267288
product: 267276
reactant: 267264
fast: false
reversible: false
type: Reaction

270812
stoichiometry: 1.0
species: 404160
type: SpeciesReference

273830
stoichiometry: 1.0
species: 404820
type: SpeciesReference

266383
local parameters: 207798
local parameters: 207796
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

207449
units: 257862
value: 4.9998E-15
type: LocalParameter

207472
units: 257775
value: 8.0E-20
type: LocalParameter

274929
stoichiometry: 1.0
species: 401560
type: SpeciesReference

265004
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208261
units: 257775
value: 1.26E-16
type: LocalParameter

265403
stoichiometry: 1.0
species: 402560
type: SpeciesReference

208069
units: 257775
value: 1.0E-16
type: LocalParameter

267312
stoichiometry: 1.0
species: 401660
type: SpeciesReference

404520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

261944
stoichiometry: 1.0
species: 405620
type: SpeciesReference

271405
stoichiometry: 1.0
species: 404320
type: SpeciesReference

207936
units: 257862
value: 3.5998992E-16
type: LocalParameter

403780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413579
kinetic law: 274954
product: 274942
product: 274929
reactant: 274917
fast: false
reversible: false
type: Reaction

259732
local parameters: 207448
local parameters: 207446
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD
type: KineticLaw

207721
units: 257862
value: 1.8106416E-16
type: LocalParameter

208172
units: 257775
value: 1.7E-18
type: LocalParameter

260254
stoichiometry: 1.0
species: 405940
type: SpeciesReference

407639
kinetic law: 260316
product: 260303
reactant: 260291
fast: false
reversible: true
type: Reaction

270293
stoichiometry: 1.0
species: 403180
type: SpeciesReference

270438
stoichiometry: 1.0
species: 403820
type: SpeciesReference

260850
local parameters: 207514
local parameters: 207512
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

274276
local parameters: 208207
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

207473
units: 257862
value: 1.08E-19
type: LocalParameter

208222
units: 257775
value: 3.5E-18
type: LocalParameter

410299
kinetic law: 266914
product: 266902
product: 266890
reactant: 266878
fast: false
reversible: false
type: Reaction

208262
units: 257775
value: 3.15E-17
type: LocalParameter

270583
stoichiometry: 1.0
species: 403180
type: SpeciesReference

263782
stoichiometry: 1.0
species: 402220
type: SpeciesReference

410419
kinetic law: 267203
product: 267191
product: 267179
reactant: 267167
fast: false
reversible: false
type: Reaction

259127
stoichiometry: 1.0
species: 402200
type: SpeciesReference

269436
local parameters: 207954
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

261604
stoichiometry: 1.0
species: 406100
type: SpeciesReference

269387
local parameters: 207953
local parameters: 207951
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

259720
stoichiometry: 1.0
species: 404280
type: SpeciesReference

264133
stoichiometry: 1.0
species: 402200
type: SpeciesReference

407679
kinetic law: 260413
product: 260401
product: 260389
reactant: 260377
fast: false
reversible: false
type: Reaction

208151
units: 257775
value: 6.8E-18
type: LocalParameter

268465
local parameters: 207904
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

262356
local parameters: 207590
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

272974
local parameters: 208140
local parameters: 208138
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

208221
units: 257775
value: 1.4E-17
type: LocalParameter

274301
stoichiometry: 1.0
species: 404280
type: SpeciesReference

272261
stoichiometry: 1.0
species: 404280
type: SpeciesReference

409519
kinetic law: 265028
product: 265016
reactant: 265004
reactant: 264992
fast: false
reversible: true
type: Reaction

259237
local parameters: 207415
local parameters: 207413
notes: kf*PKA_slash_R2C2_minus_cAMP*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP2
type: KineticLaw

412599
kinetic law: 272588
product: 272576
reactant: 272564
reactant: 272552
fast: false
reversible: true
type: Reaction

207691
units: 257862
value: 1.8106416E-16
type: LocalParameter

269882
stoichiometry: 1.0
species: 403700
type: SpeciesReference

258821
stoichiometry: 1.0
species: 401700
type: SpeciesReference

268790
stoichiometry: 1.0
species: 403480
type: SpeciesReference

402440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

411499
kinetic law: 269918
product: 269906
product: 269894
reactant: 269882
fast: false
reversible: false
type: Reaction

413399
kinetic law: 274518
product: 274506
reactant: 274494
reactant: 274482
fast: false
reversible: true
type: Reaction

207580
units: 257775
value: 5.0E-18
type: LocalParameter

207610
units: 257775
value: 1.8E-16
type: LocalParameter

409559
kinetic law: 265124
product: 265112
reactant: 265100
reactant: 265088
fast: false
reversible: true
type: Reaction

265949
local parameters: 207774
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

269544
stoichiometry: 1.0
species: 405500
type: SpeciesReference

267756
stoichiometry: 1.0
species: 403260
type: SpeciesReference

272564
stoichiometry: 1.0
species: 404280
type: SpeciesReference

271888
stoichiometry: 1.0
species: 404420
type: SpeciesReference

262054
stoichiometry: 1.0
species: 406100
type: SpeciesReference

261688
stoichiometry: 1.0
species: 405780
type: SpeciesReference

275338
stoichiometry: 1.0
species: 401660
type: SpeciesReference

268875
stoichiometry: 1.0
species: 403180
type: SpeciesReference

269093
local parameters: 207938
local parameters: 207936
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

401020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 400700
type: Species

270921
stoichiometry: 1.0
species: 404000
type: SpeciesReference

266274
stoichiometry: 1.0
species: 402760
type: SpeciesReference

411099
kinetic law: 268899
product: 268887
reactant: 268875
reactant: 268863
fast: false
reversible: true
type: Reaction

263965
local parameters: 207673
local parameters: 207671
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

258206
stoichiometry: 1.0
species: 401080
type: SpeciesReference

403920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207557
units: 257862
value: 2.77776E-19
type: LocalParameter

271489
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207824
units: 257775
value: 1.8E-16
type: LocalParameter

274120
stoichiometry: 1.0
species: 404880
type: SpeciesReference

271055
stoichiometry: 1.0
species: 403960
type: SpeciesReference

264315
stoichiometry: 1.0
species: 405240
type: SpeciesReference

207517
units: 257862
value: 2.77776E-19
type: LocalParameter

405000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

271707
local parameters: 208074
local parameters: 208072
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

408599
kinetic law: 262752
product: 262740
product: 262728
reactant: 262716
fast: false
reversible: false
type: Reaction

262308
local parameters: 207589
local parameters: 207587
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

402400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

407899
kinetic law: 260947
product: 260935
reactant: 260923
reactant: 260911
fast: false
reversible: true
type: Reaction

264353
local parameters: 207693
local parameters: 207691
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

207612
units: 257862
value: 5.81256E-17
type: LocalParameter

207582
units: 257862
value: 2.77776E-19
type: LocalParameter

266975
stoichiometry: 1.0
species: 402900
type: SpeciesReference

207559
units: 257775
value: 2.0E-17
type: LocalParameter

401600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 400700
type: Species

402320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

265608
local parameters: 207758
local parameters: 207756
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

259357
stoichiometry: 1.0
species: 403180
type: SpeciesReference

273454
local parameters: 208166
local parameters: 208164
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

405980
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

410139
kinetic law: 266527
product: 266515
product: 266503
reactant: 266491
fast: false
reversible: false
type: Reaction

207931
units: 257862
value: 3.5998992E-16
type: LocalParameter

267203
local parameters: 207839
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

270329
stoichiometry: 1.0
species: 403180
type: SpeciesReference

407499
kinetic law: 260023
product: 260011
reactant: 259999
reactant: 259987
fast: false
reversible: true
type: Reaction

405940
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400680
type: Species

273394
stoichiometry: 1.0
species: 404280
type: SpeciesReference

409439
kinetic law: 264836
product: 264824
reactant: 264812
reactant: 264800
fast: false
reversible: true
type: Reaction

262465
stoichiometry: 1.0
species: 401040
type: SpeciesReference

265233
stoichiometry: 1.0
species: 402520
type: SpeciesReference

408739
kinetic law: 263089
product: 263077
reactant: 263065
reactant: 263053
fast: false
reversible: true
type: Reaction

410799
kinetic law: 268176
product: 268164
product: 268152
reactant: 268140
fast: false
reversible: false
type: Reaction

207470
units: 257862
value: 1.08E-19
type: LocalParameter

274458
stoichiometry: 1.0
species: 404280
type: SpeciesReference

269496
stoichiometry: 1.0
species: 403620
type: SpeciesReference

271744
stoichiometry: 1.0
species: 404280
type: SpeciesReference

263891
stoichiometry: 1.0
species: 401800
type: SpeciesReference

207826
units: 257862
value: 2.011824E-17
type: LocalParameter

270244
stoichiometry: 1.0
species: 403780
type: SpeciesReference

404300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

265559
local parameters: 207754
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

207519
units: 257775
value: 2.0E-17
type: LocalParameter

270692
local parameters: 208019
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

402740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

262236
stoichiometry: 1.0
species: 405740
type: SpeciesReference

258568
stoichiometry: 1.0
species: 401580
type: SpeciesReference

411619
kinetic law: 270208
product: 270196
product: 270184
reactant: 270172
fast: false
reversible: false
type: Reaction

207584
units: 257775
value: 2.0E-17
type: LocalParameter

268538
stoichiometry: 1.0
species: 405280
type: SpeciesReference

409839
kinetic law: 265802
product: 265790
reactant: 265778
reactant: 265766
fast: false
reversible: true
type: Reaction

258471
stoichiometry: 1.0
species: 400740
type: SpeciesReference

207400
units: 257862
value: 0.0
type: LocalParameter

207514
units: 257775
value: 2.0E-17
type: LocalParameter

207829
units: 257775
value: 1.8E-16
type: LocalParameter

261250
stoichiometry: 1.0
species: 401220
type: SpeciesReference

405080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207552
units: 257862
value: 2.77776E-19
type: LocalParameter

406140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207615
units: 257775
value: 1.8E-16
type: LocalParameter

263564
stoichiometry: 1.0
species: 402160
type: SpeciesReference

268574
stoichiometry: 1.0
species: 405480
type: SpeciesReference

207696
units: 257862
value: 1.8106416E-16
type: LocalParameter

260486
stoichiometry: 1.0
species: 400800
type: SpeciesReference

207585
units: 257775
value: 5.0E-18
type: LocalParameter

260522
stoichiometry: 1.0
species: 400840
type: SpeciesReference

263259
stoichiometry: 1.0
species: 401980
type: SpeciesReference

408519
kinetic law: 262550
product: 262538
product: 262526
reactant: 262514
fast: false
reversible: false
type: Reaction

269179
stoichiometry: 1.0
species: 403560
type: SpeciesReference

207512
units: 257862
value: 1.99998E-19
type: LocalParameter

270704
stoichiometry: 1.0
species: 405560
type: SpeciesReference

412179
kinetic law: 271562
product: 271550
product: 271538
reactant: 271526
fast: false
reversible: false
type: Reaction

271091
stoichiometry: 1.0
species: 404160
type: SpeciesReference

262776
stoichiometry: 1.0
species: 401880
type: SpeciesReference

268249
stoichiometry: 1.0
species: 405480
type: SpeciesReference

260192
stoichiometry: 1.0
species: 405160
type: SpeciesReference

274856
local parameters: 208237
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

207614
units: 257775
value: 7.50006E-16
type: LocalParameter

411019
kinetic law: 268706
product: 268694
reactant: 268682
reactant: 268670
fast: false
reversible: true
type: Reaction

269954
stoichiometry: 1.0
species: 403720
type: SpeciesReference

207828
units: 257775
value: 7.2E-16
type: LocalParameter

207693
units: 257775
value: 7.2E-16
type: LocalParameter

263625
local parameters: 207654
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

410579
kinetic law: 267595
product: 267581
product: 267568
reactant: 267555
fast: false
reversible: false
type: Reaction

265875
stoichiometry: 1.0
species: 402200
type: SpeciesReference

258713
stoichiometry: 1.0
species: 401720
type: SpeciesReference

412279
kinetic law: 271804
product: 271792
reactant: 271780
reactant: 271768
fast: false
reversible: true
type: Reaction

403460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272672
stoichiometry: 1.0
species: 404580
type: SpeciesReference

266467
stoichiometry: 1.0
species: 402800
type: SpeciesReference

274349
stoichiometry: 1.0
species: 405540
type: SpeciesReference

271550
stoichiometry: 1.0
species: 404280
type: SpeciesReference

411659
kinetic law: 270305
product: 270293
product: 270281
reactant: 270269
fast: false
reversible: false
type: Reaction

402840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

410079
kinetic law: 266383
product: 266371
reactant: 266359
reactant: 266347
fast: false
reversible: true
type: Reaction

207554
units: 257775
value: 2.0E-17
type: LocalParameter

402800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207617
units: 257862
value: 6.4584E-18
type: LocalParameter

267131
stoichiometry: 1.0
species: 402200
type: SpeciesReference

266166
stoichiometry: 1.0
species: 402200
type: SpeciesReference

270644
local parameters: 208018
local parameters: 208016
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

260899
local parameters: 207515
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

273538
stoichiometry: 1.0
species: 404760
type: SpeciesReference

258676
local parameters: 207379
local parameters: 207377
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca3_minus_PSD
type: KineticLaw

271780
stoichiometry: 1.0
species: 404280
type: SpeciesReference

411699
kinetic law: 270401
product: 270389
product: 270377
reactant: 270365
fast: false
reversible: false
type: Reaction

273418
stoichiometry: 1.0
species: 405740
type: SpeciesReference

207694
units: 257775
value: 1.8E-16
type: LocalParameter

264205
local parameters: 207684
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

207401
units: 257811
value: 3.24008424E-16
type: LocalParameter

207587
units: 257862
value: 2.77776E-19
type: LocalParameter

406940
kinetic law: 258169
product: 258157
reactant: 258145
reactant: 258133
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true
type: Reaction

269846
stoichiometry: 1.0
species: 403180
type: SpeciesReference

259465
stoichiometry: 1.0
species: 403160
type: SpeciesReference

266866
local parameters: 207823
local parameters: 207821
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

263296
stoichiometry: 1.0
species: 402040
type: SpeciesReference

404260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207515
units: 257775
value: 5.0E-18
type: LocalParameter

261044
local parameters: 207524
local parameters: 207522
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

260449
stoichiometry: 1.0
species: 400880
type: SpeciesReference

258072
local parameters: 207340
local parameters: 207338
notes: kf*CaMKII_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_slash_NMDAR
type: KineticLaw

207555
units: 257775
value: 5.0E-18
type: LocalParameter

405280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

412239
kinetic law: 271707
product: 271695
reactant: 271683
reactant: 271671
fast: false
reversible: true
type: Reaction

265341
stoichiometry: 1.0
species: 405380
type: SpeciesReference

275050
stoichiometry: 1.0
species: 405040
type: SpeciesReference

413499
kinetic law: 274760
product: 274748
product: 274736
reactant: 274723
fast: false
reversible: false
type: Reaction

274410
stoichiometry: 1.0
species: 404940
type: SpeciesReference

401500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

263332
local parameters: 207640
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

207764
units: 257775
value: 1.8E-16
type: LocalParameter

403140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 400680
type: Species

272104
stoichiometry: 1.0
species: 404460
type: SpeciesReference

263101
stoichiometry: 1.0
species: 402000
type: SpeciesReference

261869
local parameters: 207565
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

265900
local parameters: 207773
local parameters: 207771
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

207589
units: 257775
value: 2.0E-17
type: LocalParameter

402900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

408699
kinetic law: 262993
product: 262981
reactant: 262969
reactant: 262956
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

208149
units: 257862
value: 8.7498E-18
type: LocalParameter

258193
stoichiometry: 1.0
species: 401020
type: SpeciesReference

266769
local parameters: 207818
local parameters: 207816
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

260095
stoichiometry: 1.0
species: 405840
type: SpeciesReference

207607
units: 257862
value: 5.81256E-17
type: LocalParameter

268646
stoichiometry: 1.0
species: 403180
type: SpeciesReference

267432
stoichiometry: 1.0
species: 403200
type: SpeciesReference

400880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 400680
type: Species

400840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

411999
kinetic law: 271127
product: 271115
reactant: 271103
reactant: 271091
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true
type: Reaction

409979
kinetic law: 266142
product: 266130
product: 266117
reactant: 266105
fast: false
reversible: false
type: Reaction

207989
units: 257775
value: 5.4E-16
type: LocalParameter

268345
stoichiometry: 1.0
species: 405360
type: SpeciesReference

207926
units: 257862
value: 3.5998992E-16
type: LocalParameter

258640
stoichiometry: 1.0
species: 401760
type: SpeciesReference

259561
local parameters: 207436
local parameters: 207434
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2
type: KineticLaw

207699
units: 257775
value: 1.8E-16
type: LocalParameter

258423
stoichiometry: 2.0
species: 400740
type: SpeciesReference

262667
stoichiometry: 1.0
species: 401820
type: SpeciesReference

207362
units: 257811
value: 6.47990604E-15
type: LocalParameter

262514
stoichiometry: 1.0
species: 401480
type: SpeciesReference

411399
kinetic law: 269678
product: 269666
reactant: 269654
reactant: 269641
fast: false
reversible: true
type: Reaction

409379
kinetic law: 264692
product: 264680
product: 264668
reactant: 264656
fast: false
reversible: false
type: Reaction

208070
units: 257775
value: 2.5E-17
type: LocalParameter

273671
stoichiometry: 1.0
species: 405640
type: SpeciesReference

403600
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

403640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272794
stoichiometry: 1.0
species: 404600
type: SpeciesReference

268297
stoichiometry: 1.0
species: 403180
type: SpeciesReference

270474
stoichiometry: 1.0
species: 405800
type: SpeciesReference

207658
units: 257775
value: 1.224E-17
type: LocalParameter

270849
stoichiometry: 1.0
species: 405900
type: SpeciesReference

207365
units: 257862
value: 3.2400162E-16
type: LocalParameter

269762
stoichiometry: 1.0
species: 403680
type: SpeciesReference

271441
stoichiometry: 1.0
species: 401000
type: SpeciesReference

264523
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207698
units: 257775
value: 7.2E-16
type: LocalParameter

261980
stoichiometry: 1.0
species: 405540
type: SpeciesReference

410239
kinetic law: 266769
product: 266757
reactant: 266745
reactant: 266732
fast: false
reversible: true
type: Reaction

265826
stoichiometry: 1.0
species: 405640
type: SpeciesReference

207550
units: 257775
value: 5.0E-18
type: LocalParameter

261470
stoichiometry: 1.0
species: 406100
type: SpeciesReference

265778
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207609
units: 257775
value: 7.50006E-16
type: LocalParameter

266431
local parameters: 207799
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

267288
stoichiometry: 1.0
species: 402200
type: SpeciesReference

267059
local parameters: 207833
local parameters: 207831
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

207763
units: 257775
value: 7.2E-16
type: LocalParameter

274228
local parameters: 208206
local parameters: 208204
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

207659
units: 257775
value: 3.06E-18
type: LocalParameter

207928
units: 257775
value: 2.16E-15
type: LocalParameter

207364
units: 257775
value: 6.48E-15
type: LocalParameter

411839
kinetic law: 270740
product: 270728
reactant: 270716
reactant: 270704
fast: false
reversible: true
type: Reaction

266818
local parameters: 207819
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

407399
kinetic law: 259648
product: 259636
reactant: 259624
reactant: 259612
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true
type: Reaction

264498
local parameters: 207699
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

400800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413179
kinetic law: 273987
product: 273975
product: 273963
reactant: 273951
fast: false
reversible: false
type: Reaction

406200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

258314
stoichiometry: 1.0
species: 401000
type: SpeciesReference

401480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

412019
kinetic law: 271177
product: 271165
product: 271152
reactant: 271140
fast: false
reversible: false
type: Reaction

405340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

267828
stoichiometry: 1.0
species: 403280
type: SpeciesReference

408080
kinetic law: 261433
product: 261421
reactant: 261409
reactant: 261397
fast: false
reversible: true
type: Reaction

259345
stoichiometry: 1.0
species: 403080
type: SpeciesReference

207831
units: 257862
value: 2.011824E-17
type: LocalParameter

272528
stoichiometry: 1.0
species: 404280
type: SpeciesReference

265997
local parameters: 207778
local parameters: 207776
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

413419
kinetic law: 274567
product: 274555
product: 274543
reactant: 274531
fast: false
reversible: false
type: Reaction

265197
stoichiometry: 1.0
species: 402200
type: SpeciesReference

267708
stoichiometry: 1.0
species: 405180
type: SpeciesReference

260740
stoichiometry: 1.0
species: 401100
type: SpeciesReference

207921
units: 257862
value: 3.5998992E-16
type: LocalParameter

274023
stoichiometry: 1.0
species: 404860
type: SpeciesReference

261797
stoichiometry: 1.0
species: 406100
type: SpeciesReference

271165
stoichiometry: 1.0
species: 404060
type: SpeciesReference

207367
units: 257775
value: 9.0E-16
type: LocalParameter

266238
local parameters: 207789
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

260401
stoichiometry: 1.0
species: 405980
type: SpeciesReference

409219
kinetic law: 264303
product: 264291
product: 264278
reactant: 264266
fast: false
reversible: false
type: Reaction

275014
stoichiometry: 1.0
species: 405080
type: SpeciesReference

273250
stoichiometry: 1.0
species: 404700
type: SpeciesReference

207871
units: 257862
value: 3.5998992E-16
type: LocalParameter

207761
units: 257862
value: 1.8106416E-16
type: LocalParameter

207984
units: 257775
value: 5.4E-16
type: LocalParameter

207833
units: 257775
value: 7.2E-16
type: LocalParameter

407999
kinetic law: 261190
product: 261178
product: 261166
reactant: 261154
fast: false
reversible: false
type: Reaction

260228
stoichiometry: 1.0
species: 405040
type: SpeciesReference

264752
stoichiometry: 1.0
species: 402420
type: SpeciesReference

267984
local parameters: 207879
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

405300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

401440
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700
type: Species

264413
stoichiometry: 1.0
species: 405420
type: SpeciesReference

404620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

404080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

273082
stoichiometry: 1.0
species: 404660
type: SpeciesReference

271598
stoichiometry: 1.0
species: 404360
type: SpeciesReference

260801
local parameters: 207511
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

405400
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207874
units: 257775
value: 5.4E-16
type: LocalParameter

259987
stoichiometry: 1.0
species: 405340
type: SpeciesReference

273142
stoichiometry: 1.0
species: 404280
type: SpeciesReference

263186
local parameters: 207634
local parameters: 207632
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

264812
stoichiometry: 1.0
species: 402200
type: SpeciesReference

265269
local parameters: 207739
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

207834
units: 257775
value: 1.8E-16
type: LocalParameter

271804
local parameters: 208079
local parameters: 208077
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

410939
kinetic law: 268514
product: 268502
reactant: 268490
reactant: 268478
fast: false
reversible: true
type: Reaction

263842
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207988
units: 257775
value: 2.16E-15
type: LocalParameter

207923
units: 257775
value: 2.16E-15
type: LocalParameter

406280
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

269448
stoichiometry: 1.0
species: 405500
type: SpeciesReference

261361
stoichiometry: 1.0
species: 405780
type: SpeciesReference

274966
stoichiometry: 1.0
species: 401540
type: SpeciesReference

261299
stoichiometry: 1.0
species: 405680
type: SpeciesReference

259309
stoichiometry: 1.0
species: 403060
type: SpeciesReference

207986
units: 257862
value: 3.999888E-17
type: LocalParameter

207873
units: 257775
value: 2.16E-15
type: LocalParameter

412739
kinetic law: 272926
product: 272914
product: 272902
reactant: 272890
fast: false
reversible: false
type: Reaction

274567
local parameters: 208222
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

410979
kinetic law: 268610
product: 268598
reactant: 268586
reactant: 268574
fast: false
reversible: true
type: Reaction

264560
stoichiometry: 1.0
species: 402380
type: SpeciesReference

258000
stoichiometry: 1.0
species: 401780
type: SpeciesReference

407319
kinetic law: 259285
product: 259273
reactant: 259261
reactant: 259249
fast: false
reversible: true
type: Reaction

269130
stoichiometry: 1.0
species: 403180
type: SpeciesReference

269020
stoichiometry: 1.0
species: 405300
type: SpeciesReference

265124
local parameters: 207733
local parameters: 207731
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

411179
kinetic law: 269142
product: 269130
product: 269118
reactant: 269105
fast: false
reversible: false
type: Reaction

406360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

270426
stoichiometry: 1.0
species: 403180
type: SpeciesReference

409779
kinetic law: 265656
product: 265644
product: 265632
reactant: 265620
fast: false
reversible: false
type: Reaction

260959
stoichiometry: 1.0
species: 401160
type: SpeciesReference

268140
stoichiometry: 1.0
species: 403340
type: SpeciesReference

207368
units: 257862
value: 2.7000216E-17
type: LocalParameter

268754
local parameters: 207919
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

269726
local parameters: 207969
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

207924
units: 257775
value: 5.4E-16
type: LocalParameter

265668
stoichiometry: 1.0
species: 405340
type: SpeciesReference

208141
units: 257775
value: 1.7E-18
type: LocalParameter

274132
local parameters: 208201
local parameters: 208199
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

401060
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

266347
stoichiometry: 1.0
species: 405700
type: SpeciesReference

268826
stoichiometry: 1.0
species: 405340
type: SpeciesReference

208167
units: 257775
value: 1.7E-18
type: LocalParameter

271213
stoichiometry: 1.0
species: 404120
type: SpeciesReference

271381
stoichiometry: 1.0
species: 401040
type: SpeciesReference

402080
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

264860
stoichiometry: 1.0
species: 405400
type: SpeciesReference

265305
stoichiometry: 1.0
species: 402540
type: SpeciesReference

265040
stoichiometry: 1.0
species: 402480
type: SpeciesReference

261202
stoichiometry: 1.0
species: 405500
type: SpeciesReference

268971
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207719
units: 257775
value: 1.8E-16
type: LocalParameter

207981
units: 257862
value: 3.999888E-17
type: LocalParameter

207651
units: 257862
value: 3.0779838E-18
type: LocalParameter

401700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208100
units: 257775
value: 1.7E-18
type: LocalParameter

275122
stoichiometry: 1.0
species: 405100
type: SpeciesReference

265487
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207876
units: 257862
value: 3.5998992E-16
type: LocalParameter

261567
stoichiometry: 1.0
species: 406100
type: SpeciesReference

208140
units: 257775
value: 6.8E-18
type: LocalParameter

269338
local parameters: 207949
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

263149
stoichiometry: 1.0
species: 400840
type: SpeciesReference

208166
units: 257775
value: 6.8E-18
type: LocalParameter

265716
stoichiometry: 1.0
species: 402620
type: SpeciesReference

269069
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274603
stoichiometry: 1.0
species: 404980
type: SpeciesReference

207941
units: 257862
value: 3.5998992E-16
type: LocalParameter

275326
stoichiometry: 1.0
species: 401600
type: SpeciesReference

208075
units: 257775
value: 1.7E-18
type: LocalParameter

261821
local parameters: 207564
local parameters: 207562
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

259660
stoichiometry: 1.0
species: 404160
type: SpeciesReference

402040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

259903
stoichiometry: 1.0
species: 405200
type: SpeciesReference

412439
kinetic law: 272189
product: 272177
reactant: 272165
reactant: 272152
fast: false
reversible: true
type: Reaction

257787
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

208143
units: 257862
value: 8.7498E-18
type: LocalParameter

273190
stoichiometry: 1.0
species: 405540
type: SpeciesReference

207879
units: 257775
value: 5.4E-16
type: LocalParameter

271514
local parameters: 208064
local parameters: 208062
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

267876
stoichiometry: 1.0
species: 403180
type: SpeciesReference

270680
stoichiometry: 1.0
species: 403180
type: SpeciesReference

263733
stoichiometry: 1.0
species: 401560
type: SpeciesReference

408779
kinetic law: 263186
product: 263174
reactant: 263162
reactant: 263149
fast: false
reversible: true
type: Reaction

272866
stoichiometry: 1.0
species: 404620
type: SpeciesReference

259040
local parameters: 207403
local parameters: 207401
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4
type: KineticLaw

260679
stoichiometry: 1.0
species: 400800
type: SpeciesReference

270534
stoichiometry: 1.0
species: 403840
type: SpeciesReference

207943
units: 257775
value: 2.16E-15
type: LocalParameter

208102
units: 257862
value: 8.7498E-18
type: LocalParameter

275098
stoichiometry: 1.0
species: 405100
type: SpeciesReference

207983
units: 257775
value: 2.16E-15
type: LocalParameter

408259
kinetic law: 261869
product: 261857
product: 261845
reactant: 261833
fast: false
reversible: false
type: Reaction

402360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

263077
stoichiometry: 1.0
species: 402000
type: SpeciesReference

263443
stoichiometry: 1.0
species: 400940
type: SpeciesReference

264450
local parameters: 207698
local parameters: 207696
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

261141
local parameters: 207529
local parameters: 207527
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

408299
kinetic law: 261968
product: 261956
product: 261944
reactant: 261932
fast: false
reversible: false
type: Reaction

266611
stoichiometry: 1.0
species: 402200
type: SpeciesReference

404340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

402000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207878
units: 257775
value: 2.16E-15
type: LocalParameter

259780
local parameters: 207451
local parameters: 207449
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

406900
kinetic law: 258072
product: 258060
product: 258048
reactant: 258036
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

273202
stoichiometry: 1.0
species: 404280
type: SpeciesReference

269617
stoichiometry: 1.0
species: 403180
type: SpeciesReference

273769
stoichiometry: 1.0
species: 405680
type: SpeciesReference

208164
units: 257862
value: 8.7498E-18
type: LocalParameter

410759
kinetic law: 268080
product: 268068
product: 268056
reactant: 268044
fast: false
reversible: false
type: Reaction

207944
units: 257775
value: 5.4E-16
type: LocalParameter

258362
stoichiometry: 1.0
species: 401040
type: SpeciesReference

271912
stoichiometry: 1.0
species: 404420
type: SpeciesReference

267240
stoichiometry: 1.0
species: 402960
type: SpeciesReference

208077
units: 257862
value: 8.7498E-18
type: LocalParameter

267936
local parameters: 207878
local parameters: 207876
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

264704
stoichiometry: 1.0
species: 405480
type: SpeciesReference

407420
kinetic law: 259732
product: 259720
product: 259708
reactant: 259696
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

259624
stoichiometry: 1.0
species: 401780
type: SpeciesReference

268429
stoichiometry: 1.0
species: 403400
type: SpeciesReference

264242
stoichiometry: 1.0
species: 402320
type: SpeciesReference

261080
stoichiometry: 1.0
species: 406100
type: SpeciesReference

270074
stoichiometry: 1.0
species: 403740
type: SpeciesReference

207929
units: 257775
value: 5.4E-16
type: LocalParameter

270897
stoichiometry: 1.0
species: 404160
type: SpeciesReference

403180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

259513
stoichiometry: 1.0
species: 403900
type: SpeciesReference

273298
stoichiometry: 1.0
species: 404280
type: SpeciesReference

269508
stoichiometry: 1.0
species: 405580
type: SpeciesReference

268237
stoichiometry: 1.0
species: 403360
type: SpeciesReference

261712
stoichiometry: 1.0
species: 401320
type: SpeciesReference

207769
units: 257775
value: 1.8E-16
type: LocalParameter

405720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

260365
local parameters: 207490
local parameters: 207488
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

208104
units: 257775
value: 6.8E-18
type: LocalParameter

402580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272213
stoichiometry: 1.0
species: 405600
type: SpeciesReference

259381
local parameters: 207424
local parameters: 207422
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4
type: KineticLaw

208072
units: 257862
value: 8.7498E-18
type: LocalParameter

207440
units: 257862
value: 6.479838E-14
type: LocalParameter

267542
local parameters: 207858
local parameters: 207856
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

407859
kinetic law: 260850
product: 260838
reactant: 260825
reactant: 260813
fast: false
reversible: true
type: Reaction

413639
kinetic law: 275110
product: 275098
reactant: 275086
reactant: 275074
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true
type: Reaction

265596
stoichiometry: 1.0
species: 402600
type: SpeciesReference

207479
units: 257775
value: 2.25E-16
type: LocalParameter

262872
stoichiometry: 1.0
species: 401880
type: SpeciesReference

401860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413139
kinetic law: 273891
product: 273879
product: 273867
reactant: 273855
fast: false
reversible: false
type: Reaction

262956
stoichiometry: 1.0
species: 404240
type: SpeciesReference

208105
units: 257775
value: 1.7E-18
type: LocalParameter

267581
stoichiometry: 1.0
species: 403180
type: SpeciesReference

262090
stoichiometry: 1.0
species: 406100
type: SpeciesReference

207656
units: 257862
value: 3.420036E-19
type: LocalParameter

273879
stoichiometry: 1.0
species: 404280
type: SpeciesReference

405120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

410539
kinetic law: 267492
product: 267480
product: 267468
reactant: 267456
fast: false
reversible: false
type: Reaction

207716
units: 257862
value: 1.8106416E-16
type: LocalParameter

412339
kinetic law: 271948
product: 271936
product: 271924
reactant: 271912
fast: false
reversible: false
type: Reaction

268935
stoichiometry: 1.0
species: 403180
type: SpeciesReference

258048
stoichiometry: 1.0
species: 400940
type: SpeciesReference

208147
units: 257775
value: 1.7E-18
type: LocalParameter

207361
units: 257775
value: 1.0E-18
type: LocalParameter

264632
stoichiometry: 1.0
species: 402400
type: SpeciesReference

262138
stoichiometry: 1.0
species: 405800
type: SpeciesReference

260911
stoichiometry: 1.0
species: 405680
type: SpeciesReference

208169
units: 257862
value: 8.7498E-18
type: LocalParameter

268188
stoichiometry: 1.0
species: 405200
type: SpeciesReference

265620
stoichiometry: 1.0
species: 402600
type: SpeciesReference

269990
stoichiometry: 1.0
species: 405600
type: SpeciesReference

258979
stoichiometry: 1.0
species: 401800
type: SpeciesReference

274796
stoichiometry: 1.0
species: 405020
type: SpeciesReference

268682
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207653
units: 257775
value: 1.224E-17
type: LocalParameter

271103
stoichiometry: 1.0
species: 404060
type: SpeciesReference

207766
units: 257862
value: 2.011824E-17
type: LocalParameter

403420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270365
stoichiometry: 1.0
species: 403800
type: SpeciesReference

408940
kinetic law: 263625
product: 263612
product: 263600
reactant: 263588
fast: false
reversible: false
type: Reaction

207442
units: 257775
value: 4.5E-16
type: LocalParameter

266720
local parameters: 207814
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

266587
stoichiometry: 1.0
species: 402820
type: SpeciesReference

273562
stoichiometry: 1.0
species: 404760
type: SpeciesReference

208074
units: 257775
value: 6.8E-18
type: LocalParameter

409039
kinetic law: 263866
product: 263854
reactant: 263842
reactant: 263830
fast: false
reversible: true
type: Reaction

405760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

269654
stoichiometry: 1.0
species: 403180
type: SpeciesReference

409079
kinetic law: 263965
product: 263952
reactant: 263940
reactant: 263928
fast: false
reversible: true
type: Reaction

259004
stoichiometry: 2.0
species: 400740
type: SpeciesReference

208146
units: 257775
value: 6.8E-18
type: LocalParameter

260047
stoichiometry: 1.0
species: 405840
type: SpeciesReference

404940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

272757
stoichiometry: 1.0
species: 404280
type: SpeciesReference

270136
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207768
units: 257775
value: 7.2E-16
type: LocalParameter

264980
local parameters: 207724
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

267396
local parameters: 207849
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

402780
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413345
kinetic law: 274373
product: 274361
product: 274349
reactant: 274337
fast: false
reversible: false
type: Reaction

270208
local parameters: 207994
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

207654
units: 257775
value: 3.06E-18
type: LocalParameter

208107
units: 257862
value: 8.7498E-18
type: LocalParameter

406980
kinetic law: 258254
product: 258242
reactant: 258230
fast: false
reversible: true
type: Reaction

408019
kinetic law: 261238
product: 261226
reactant: 261214
reactant: 261202
fast: false
reversible: true
type: Reaction

207718
units: 257775
value: 7.2E-16
type: LocalParameter

401760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

271695
stoichiometry: 1.0
species: 404380
type: SpeciesReference

411120
kinetic law: 268995
product: 268983
reactant: 268971
reactant: 268959
fast: false
reversible: true
type: Reaction

412399
kinetic law: 272092
product: 272080
reactant: 272068
reactant: 272056
fast: false
reversible: true
type: Reaction

269460
stoichiometry: 1.0
species: 403180
type: SpeciesReference

262981
stoichiometry: 1.0
species: 401960
type: SpeciesReference

273022
local parameters: 208141
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

207433
units: 257775
value: 9.0E-17
type: LocalParameter

207738
units: 257775
value: 7.2E-16
type: LocalParameter

264548
local parameters: 207703
local parameters: 207701
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

268586
stoichiometry: 1.0
species: 403180
type: SpeciesReference

266045
local parameters: 207779
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

408039
kinetic law: 261286
product: 261274
product: 261262
reactant: 261250
fast: false
reversible: false
type: Reaction

403800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207337
units: 257775
value: 9.0E-18
type: LocalParameter

267035
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207338
units: 257775
value: 3.0E-18
type: LocalParameter

265523
stoichiometry: 1.0
species: 402580
type: SpeciesReference

268382
stoichiometry: 1.0
species: 405440
type: SpeciesReference

258616
stoichiometry: 1.0
species: 401760
type: SpeciesReference

273999
stoichiometry: 1.0
species: 405800
type: SpeciesReference

271006
stoichiometry: 1.0
species: 404020
type: SpeciesReference

263504
stoichiometry: 1.0
species: 400760
type: SpeciesReference

263393
stoichiometry: 1.0
species: 402060
type: SpeciesReference

408999
kinetic law: 263770
product: 263757
reactant: 263745
reactant: 263733
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

208214
units: 257862
value: 8.7498E-18
type: LocalParameter

409339
kinetic law: 264596
product: 264584
product: 264572
reactant: 264560
fast: false
reversible: false
type: Reaction

259939
stoichiometry: 1.0
species: 405500
type: SpeciesReference

272056
stoichiometry: 1.0
species: 405760
type: SpeciesReference

269690
stoichiometry: 1.0
species: 403660
type: SpeciesReference

266708
stoichiometry: 1.0
species: 402200
type: SpeciesReference

264037
stoichiometry: 1.0
species: 402200
type: SpeciesReference

407359
kinetic law: 259477
product: 259465
reactant: 259453
reactant: 259441
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true
type: Reaction

405800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

264920
stoichiometry: 1.0
species: 402460
type: SpeciesReference

270172
stoichiometry: 1.0
species: 403760
type: SpeciesReference

405840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 400700
type: Species

270740
local parameters: 208023
local parameters: 208021
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

207434
units: 257775
value: 9.0E-18
type: LocalParameter

406240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

208254
units: 257862
value: 1.020006E-18
type: LocalParameter

268044
stoichiometry: 1.0
species: 403320
type: SpeciesReference

275158
local parameters: 208252
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

402220
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272914
stoichiometry: 1.0
species: 404280
type: SpeciesReference

208181
units: 257775
value: 1.4E-17
type: LocalParameter

273635
stoichiometry: 1.0
species: 404780
type: SpeciesReference

410699
kinetic law: 267936
product: 267924
reactant: 267912
reactant: 267900
fast: false
reversible: true
type: Reaction

400700
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

267684
stoichiometry: 1.0
species: 403180
type: SpeciesReference

409739
kinetic law: 265559
product: 265547
product: 265535
reactant: 265523
fast: false
reversible: false
type: Reaction

409619
kinetic law: 265269
product: 265257
product: 265245
reactant: 265233
fast: false
reversible: false
type: Reaction

260156
stoichiometry: 1.0
species: 405680
type: SpeciesReference

208059
units: 257775
value: 1.0E-16
type: LocalParameter

272648
stoichiometry: 1.0
species: 405600
type: SpeciesReference

271948
local parameters: 208085
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

266647
stoichiometry: 1.0
species: 402200
type: SpeciesReference

405560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

408919
kinetic law: 263528
product: 263516
product: 263504
reactant: 263492
fast: false
reversible: false
type: Reaction

207335
units: 257862
value: 9.001692E-14
type: LocalParameter

207431
units: 257862
value: 4.4999712E-15
type: LocalParameter

263661
stoichiometry: 1.0
species: 402180
type: SpeciesReference

207736
units: 257862
value: 1.8106416E-16
type: LocalParameter

412359
kinetic law: 271996
product: 271984
reactant: 271972
reactant: 271960
fast: false
reversible: true
type: Reaction

259405
stoichiometry: 1.0
species: 403180
type: SpeciesReference

273238
stoichiometry: 1.0
species: 404280
type: SpeciesReference

257952
stoichiometry: 1.0
species: 400760
type: SpeciesReference

270014
local parameters: 207984
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

259890
stoichiometry: 1.0
species: 405520
type: SpeciesReference

413519
kinetic law: 274808
product: 274796
reactant: 274784
reactant: 274772
fast: false
reversible: true
type: Reaction

272092
local parameters: 208094
local parameters: 208092
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

208182
units: 257775
value: 3.5E-18
type: LocalParameter

261749
stoichiometry: 1.0
species: 405800
type: SpeciesReference

410619
kinetic law: 267696
product: 267684
product: 267672
reactant: 267660
fast: false
reversible: false
type: Reaction

257888
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

207487
units: 257775
value: 1.0E-15
type: LocalParameter

401880
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 400680
type: Species

275278
stoichiometry: 1.0
species: 405040
type: SpeciesReference

208216
units: 257775
value: 1.4E-17
type: LocalParameter

262848
local parameters: 207615
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

410339
kinetic law: 267011
product: 266999
product: 266987
reactant: 266975
fast: false
reversible: false
type: Reaction

401120
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

257848
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

266902
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207334
units: 257775
value: 4.5E-16
type: LocalParameter

258906
stoichiometry: 1.0
species: 401820
type: SpeciesReference

274711
local parameters: 208231
local parameters: 208229
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

208256
units: 257775
value: 2.106E-16
type: LocalParameter

207949
units: 257775
value: 5.4E-16
type: LocalParameter

258157
stoichiometry: 1.0
species: 401060
type: SpeciesReference

269227
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274071
stoichiometry: 1.0
species: 404280
type: SpeciesReference

408959
kinetic law: 263673
product: 263661
reactant: 263649
reactant: 263637
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

409659
kinetic law: 265366
product: 265353
product: 265341
reactant: 265329
fast: false
reversible: false
type: Reaction

408399
kinetic law: 262211
product: 262199
reactant: 262187
reactant: 262175
fast: false
reversible: true
type: Reaction

259285
local parameters: 207418
local parameters: 207416
notes: kf*PKA_slash_R2C2_minus_cAMP2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP3
type: KineticLaw

266154
stoichiometry: 1.0
species: 405760
type: SpeciesReference

263356
stoichiometry: 1.0
species: 401980
type: SpeciesReference

412059
kinetic law: 271273
product: 271261
product: 271249
reactant: 271237
fast: false
reversible: false
type: Reaction

260643
stoichiometry: 1.0
species: 400920
type: SpeciesReference

405880
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700
type: Species

274687
stoichiometry: 1.0
species: 404280
type: SpeciesReference

267720
stoichiometry: 1.0
species: 403180
type: SpeciesReference

266117
stoichiometry: 1.0
species: 405500
type: SpeciesReference

207488
units: 257862
value: 2.3767344E-17
type: LocalParameter

269276
stoichiometry: 1.0
species: 403580
type: SpeciesReference

407140
kinetic law: 258628
product: 258616
reactant: 258604
reactant: 258592
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

259829
local parameters: 207454
local parameters: 207452
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*AMPAR_memb_slash_Anchor
type: KineticLaw

261956
stoichiometry: 1.0
species: 406100
type: SpeciesReference

269810
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207734
units: 257775
value: 1.8E-16
type: LocalParameter

265415
local parameters: 207748
local parameters: 207746
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

207948
units: 257775
value: 2.16E-15
type: LocalParameter

401260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700
type: Species

405540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

261458
stoichiometry: 1.0
species: 405720
type: SpeciesReference

268718
stoichiometry: 1.0
species: 403460
type: SpeciesReference

267324
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208057
units: 257862
value: 6.2502E-17
type: LocalParameter

272950
stoichiometry: 1.0
species: 404280
type: SpeciesReference

411339
kinetic law: 269532
product: 269520
product: 269508
reactant: 269496
fast: false
reversible: false
type: Reaction

208162
units: 257775
value: 1.7E-18
type: LocalParameter

274264
stoichiometry: 1.0
species: 404280
type: SpeciesReference

260862
stoichiometry: 1.0
species: 401120
type: SpeciesReference

207485
units: 257775
value: 1.0E-15
type: LocalParameter

411279
kinetic law: 269387
product: 269374
reactant: 269362
reactant: 269350
fast: false
reversible: true
type: Reaction

259744
stoichiometry: 1.0
species: 404220
type: SpeciesReference

266830
stoichiometry: 1.0
species: 405660
type: SpeciesReference

272890
stoichiometry: 1.0
species: 404620
type: SpeciesReference

207620
units: 257775
value: 1.8E-16
type: LocalParameter

208184
units: 257862
value: 8.7498E-18
type: LocalParameter

207733
units: 257775
value: 7.2E-16
type: LocalParameter

207590
units: 257775
value: 5.0E-18
type: LocalParameter

270281
stoichiometry: 1.0
species: 405720
type: SpeciesReference

260266
stoichiometry: 1.0
species: 400740
type: SpeciesReference

263770
local parameters: 207663
local parameters: 207661
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

266793
stoichiometry: 1.0
species: 405540
type: SpeciesReference

270861
stoichiometry: 1.0
species: 404160
type: SpeciesReference

408239
kinetic law: 261821
product: 261809
reactant: 261797
reactant: 261785
fast: false
reversible: true
type: Reaction

272806
stoichiometry: 1.0
species: 405500
type: SpeciesReference

401540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270595
local parameters: 208014
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

265378
stoichiometry: 1.0
species: 405280
type: SpeciesReference

402500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

274313
stoichiometry: 1.0
species: 404920
type: SpeciesReference

272962
stoichiometry: 1.0
species: 404640
type: SpeciesReference

269399
stoichiometry: 1.0
species: 403600
type: SpeciesReference

207439
units: 257775
value: 0.0
type: LocalParameter

264145
stoichiometry: 1.0
species: 402300
type: SpeciesReference

262368
stoichiometry: 1.0
species: 405520
type: SpeciesReference

259078
stoichiometry: 1.0
species: 402120
type: SpeciesReference

269423
stoichiometry: 1.0
species: 403180
type: SpeciesReference

267095
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208055
units: 257775
value: 2.5E-17
type: LocalParameter

207946
units: 257862
value: 3.999888E-17
type: LocalParameter

271273
local parameters: 208050
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

262151
stoichiometry: 1.0
species: 406100
type: SpeciesReference

264061
local parameters: 207678
local parameters: 207676
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

272008
stoichiometry: 1.0
species: 404440
type: SpeciesReference

271321
local parameters: 208054
local parameters: 208052
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

404460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

413459
kinetic law: 274663
product: 274651
product: 274639
reactant: 274627
fast: false
reversible: false
type: Reaction

208251
units: 257775
value: 1.44E-15
type: LocalParameter

259176
stoichiometry: 1.0
species: 403020
type: SpeciesReference

208212
units: 257775
value: 3.5E-18
type: LocalParameter

260119
local parameters: 207472
local parameters: 207470
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_
type: KineticLaw

274820
stoichiometry: 1.0
species: 405020
type: SpeciesReference

258266
stoichiometry: 1.0
species: 401060
type: SpeciesReference

207549
units: 257775
value: 2.0E-17
type: LocalParameter

207731
units: 257862
value: 1.8106416E-16
type: LocalParameter

208186
units: 257775
value: 1.4E-17
type: LocalParameter

268502
stoichiometry: 1.0
species: 403420
type: SpeciesReference

271984
stoichiometry: 1.0
species: 404440
type: SpeciesReference

207436
units: 257775
value: 0.0
type: LocalParameter

273915
stoichiometry: 1.0
species: 404280
type: SpeciesReference

272346
stoichiometry: 1.0
species: 405600
type: SpeciesReference

273358
local parameters: 208161
local parameters: 208159
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

262429
stoichiometry: 1.0
species: 405560
type: SpeciesReference

413059
kinetic law: 273695
product: 273683
product: 273671
reactant: 273659
fast: false
reversible: false
type: Reaction

208252
units: 257775
value: 3.6E-16
type: LocalParameter

208211
units: 257775
value: 1.4E-17
type: LocalParameter

208161
units: 257775
value: 6.8E-18
type: LocalParameter

265016
stoichiometry: 1.0
species: 402480
type: SpeciesReference

207484
units: 257775
value: 9.0E-15
type: LocalParameter

272165
stoichiometry: 1.0
species: 404280
type: SpeciesReference

261128
stoichiometry: 1.0
species: 401200
type: SpeciesReference

207437
units: 257775
value: 9.0E-19
type: LocalParameter

273842
local parameters: 208186
local parameters: 208184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

266371
stoichiometry: 1.0
species: 402780
type: SpeciesReference

258943
local parameters: 207397
local parameters: 207395
notes: kf*PP1_slash_I1_star_*PP1_slash_PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

208187
units: 257775
value: 3.5E-18
type: LocalParameter

264968
stoichiometry: 1.0
species: 402200
type: SpeciesReference

264365
stoichiometry: 1.0
species: 402340
type: SpeciesReference

207481
units: 257775
value: 2.25E-16
type: LocalParameter

266987
stoichiometry: 1.0
species: 405740
type: SpeciesReference

207547
units: 257862
value: 2.77776E-19
type: LocalParameter

402960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

262589
stoichiometry: 1.0
species: 401500
type: SpeciesReference

262908
stoichiometry: 1.0
species: 401940
type: SpeciesReference

260753
local parameters: 207510
local parameters: 207508
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

260328
stoichiometry: 1.0
species: 400840
type: SpeciesReference

263928
stoichiometry: 1.0
species: 401840
type: SpeciesReference

411539
kinetic law: 270014
product: 270002
product: 269990
reactant: 269978
fast: false
reversible: false
type: Reaction

207594
units: 257775
value: 2.0E-17
type: LocalParameter

403340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270788
local parameters: 208024
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

412799
kinetic law: 273070
product: 273058
reactant: 273046
reactant: 273034
fast: false
reversible: true
type: Reaction

207508
units: 257862
value: 2.4E-18
type: LocalParameter

267215
stoichiometry: 1.0
species: 405740
type: SpeciesReference

401320
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 400700
type: Species

408459
kinetic law: 262405
product: 262393
reactant: 262380
reactant: 262368
fast: false
reversible: true
type: Reaction

409599
kinetic law: 265221
product: 265209
reactant: 265197
reactant: 265185
fast: false
reversible: true
type: Reaction

404980
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

406340
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

273466
stoichiometry: 1.0
species: 404740
type: SpeciesReference

207839
units: 257775
value: 1.8E-16
type: LocalParameter

207625
units: 257775
value: 1.8E-16
type: LocalParameter

207482
units: 257775
value: 9.0E-15
type: LocalParameter

401360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700
type: Species

262477
stoichiometry: 1.0
species: 406120
type: SpeciesReference

407460
kinetic law: 259878
product: 259866
product: 259854
reactant: 259841
fast: false
reversible: true
type: Reaction

207595
units: 257775
value: 5.0E-18
type: LocalParameter

265221
local parameters: 207738
local parameters: 207736
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

403380
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270232
stoichiometry: 1.0
species: 403180
type: SpeciesReference

270970
stoichiometry: 1.0
species: 403980
type: SpeciesReference

271756
local parameters: 208075
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

207838
units: 257775
value: 7.2E-16
type: LocalParameter

207624
units: 257775
value: 7.50006E-16
type: LocalParameter

269894
stoichiometry: 1.0
species: 405700
type: SpeciesReference

404900
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

269007
stoichiometry: 1.0
species: 403520
type: SpeciesReference

258833
stoichiometry: 1.0
species: 400740
type: SpeciesReference

207592
units: 257862
value: 2.77776E-19
type: LocalParameter

207622
units: 257862
value: 6.4584E-18
type: LocalParameter

263405
stoichiometry: 1.0
species: 400940
type: SpeciesReference

259225
stoichiometry: 1.0
species: 403040
type: SpeciesReference

268478
stoichiometry: 1.0
species: 405260
type: SpeciesReference

258870
stoichiometry: 1.0
species: 401720
type: SpeciesReference

268863
stoichiometry: 1.0
species: 405220
type: SpeciesReference

207506
units: 257775
value: 4.5E-17
type: LocalParameter

272576
stoichiometry: 1.0
species: 404560
type: SpeciesReference

407299
kinetic law: 259188
product: 259176
reactant: 259164
reactant: 259152
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true
type: Reaction

269532
local parameters: 207959
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

267768
stoichiometry: 1.0
species: 405220
type: SpeciesReference

207544
units: 257775
value: 2.0E-17
type: LocalParameter

271876
stoichiometry: 1.0
species: 404280
type: SpeciesReference

261676
local parameters: 207555
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

262042
stoichiometry: 1.0
species: 405560
type: SpeciesReference

403300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

270933
local parameters: 208034
local parameters: 208032
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

266262
stoichiometry: 1.0
species: 402200
type: SpeciesReference

263977
stoichiometry: 1.0
species: 402260
type: SpeciesReference

258218
local parameters: 207349
local parameters: 207347
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

272600
stoichiometry: 1.0
species: 404560
type: SpeciesReference

402540
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272274
stoichiometry: 1.0
species: 404500
type: SpeciesReference

405180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

409239
kinetic law: 264353
product: 264340
reactant: 264327
reactant: 264315
fast: false
reversible: true
type: Reaction

407040
kinetic law: 258398
product: 258386
reactant: 258374
reactant: 258362
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

207505
units: 257775
value: 1.8E-16
type: LocalParameter

271719
stoichiometry: 1.0
species: 404380
type: SpeciesReference

275230
stoichiometry: 1.0
species: 401660
type: SpeciesReference

207545
units: 257775
value: 5.0E-18
type: LocalParameter

264327
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207836
units: 257862
value: 2.011824E-17
type: LocalParameter

264291
stoichiometry: 1.0
species: 402200
type: SpeciesReference

271477
stoichiometry: 1.0
species: 400980
type: SpeciesReference

271043
stoichiometry: 1.0
species: 404040
type: SpeciesReference

410719
kinetic law: 267984
product: 267972
product: 267960
reactant: 267948
fast: false
reversible: false
type: Reaction

266479
local parameters: 207803
local parameters: 207801
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

412999
kinetic law: 273550
product: 273538
reactant: 273526
reactant: 273514
fast: false
reversible: true
type: Reaction

406060
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700
type: Species

258725
local parameters: 207382
local parameters: 207380
notes: kf*CaM_slash_CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD
type: KineticLaw

265863
stoichiometry: 1.0
species: 405680
type: SpeciesReference

207629
units: 257775
value: 9.0E-16
type: LocalParameter

405620
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207542
units: 257862
value: 2.77776E-19
type: LocalParameter

267143
stoichiometry: 1.0
species: 402940
type: SpeciesReference

208257
units: 257775
value: 5.22E-17
type: LocalParameter

264217
stoichiometry: 1.0
species: 405220
type: SpeciesReference

207599
units: 257775
value: 2.4E-16
type: LocalParameter

269858
stoichiometry: 1.0
species: 403700
type: SpeciesReference

258664
stoichiometry: 1.0
species: 401740
type: SpeciesReference

273526
stoichiometry: 1.0
species: 404280
type: SpeciesReference

409399
kinetic law: 264740
product: 264728
reactant: 264716
reactant: 264704
fast: false
reversible: true
type: Reaction

271792
stoichiometry: 1.0
species: 404400
type: SpeciesReference

263612
stoichiometry: 1.0
species: 402140
type: SpeciesReference

261056
stoichiometry: 1.0
species: 401180
type: SpeciesReference

270631
stoichiometry: 1.0
species: 403860
type: SpeciesReference

407579
kinetic law: 260204
product: 260192
reactant: 260180
fast: false
reversible: true
type: Reaction

260437
stoichiometry: 1.0
species: 405980
type: SpeciesReference

266878
stoichiometry: 1.0
species: 402880
type: SpeciesReference

412959
kinetic law: 273454
product: 273442
reactant: 273430
reactant: 273418
fast: false
reversible: true
type: Reaction

259453
stoichiometry: 1.0
species: 403140
type: SpeciesReference

263284
local parameters: 207639
local parameters: 207637
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

406020
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 400680
type: Species

258084
stoichiometry: 1.0
species: 401000
type: SpeciesReference

207503
units: 257862
value: 1.2857616E-18
type: LocalParameter

267792
local parameters: 207869
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

407539
kinetic law: 260119
product: 260107
reactant: 260095
reactant: 260083
fast: false
reversible: true
type: Reaction

269350
stoichiometry: 1.0
species: 405580
type: SpeciesReference

273310
local parameters: 208157
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

274531
stoichiometry: 1.0
species: 404960
type: SpeciesReference

269166
stoichiometry: 1.0
species: 403180
type: SpeciesReference

258483
stoichiometry: 1.0
species: 401700
type: SpeciesReference

207501
units: 257775
value: 5.4E-16
type: LocalParameter

266009
stoichiometry: 1.0
species: 402700
type: SpeciesReference

262248
stoichiometry: 1.0
species: 406100
type: SpeciesReference

412639
kinetic law: 272685
product: 272672
reactant: 272660
reactant: 272648
fast: false
reversible: true
type: Reaction

410039
kinetic law: 266286
product: 266274
reactant: 266262
reactant: 266250
fast: false
reversible: true
type: Reaction

261348
stoichiometry: 1.0
species: 401240
type: SpeciesReference

258556
stoichiometry: 1.0
species: 401560
type: SpeciesReference

207540
units: 257775
value: 5.0E-18
type: LocalParameter

207627
units: 257862
value: 2.2062942E-16
type: LocalParameter

404100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

402480
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

408419
kinetic law: 262308
product: 262296
reactant: 262284
reactant: 262272
fast: false
reversible: true
type: Reaction

408099
kinetic law: 261482
product: 261470
product: 261458
reactant: 261445
fast: false
reversible: false
type: Reaction

208259
units: 257862
value: 6.11982E-19
type: LocalParameter

263552
stoichiometry: 1.0
species: 402140
type: SpeciesReference

413239
kinetic law: 274132
product: 274120
reactant: 274107
reactant: 274095
fast: false
reversible: true
type: Reaction

405200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

413279
kinetic law: 274228
product: 274216
reactant: 274204
reactant: 274192
fast: false
reversible: true
type: Reaction

403960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

272685
local parameters: 208125
local parameters: 208123
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

207597
units: 257862
value: 3.69594E-18
type: LocalParameter

260534
stoichiometry: 1.0
species: 406000
type: SpeciesReference

262199
stoichiometry: 1.0
species: 401420
type: SpeciesReference

405240
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

412919
kinetic law: 273358
product: 273346
reactant: 273334
reactant: 273322
fast: false
reversible: true
type: Reaction

207500
units: 257775
value: 2.16E-15
type: LocalParameter

271369
local parameters: 208055
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

404140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400720
type: Species

260474
stoichiometry: 1.0
species: 400880
type: SpeciesReference

263247
stoichiometry: 1.0
species: 400820
type: SpeciesReference

274180
local parameters: 208202
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

269118
stoichiometry: 1.0
species: 405320
type: SpeciesReference

269966
local parameters: 207983
local parameters: 207981
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

261397
stoichiometry: 1.0
species: 405640
type: SpeciesReference

262550
local parameters: 207600
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

274868
stoichiometry: 1.0
species: 401580
type: SpeciesReference

262764
stoichiometry: 1.0
species: 401840
type: SpeciesReference

272782
local parameters: 208130
local parameters: 208128
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

207774
units: 257775
value: 1.8E-16
type: LocalParameter

270486
stoichiometry: 1.0
species: 403180
type: SpeciesReference

412899
kinetic law: 273310
product: 273298
product: 273286
reactant: 273274
fast: false
reversible: false
type: Reaction

273683
stoichiometry: 1.0
species: 404280
type: SpeciesReference

269750
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207841
units: 257862
value: 2.011824E-17
type: LocalParameter

402100
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 400680
type: Species

405460
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207377
units: 257862
value: 3.6E-17
type: LocalParameter

264535
stoichiometry: 1.0
species: 402380
type: SpeciesReference

404200
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 400700
type: Species

267107
local parameters: 207834
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

403740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

402860
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207881
units: 257862
value: 3.5998992E-16
type: LocalParameter

274216
stoichiometry: 1.0
species: 404900
type: SpeciesReference

267047
stoichiometry: 1.0
species: 402920
type: SpeciesReference

402260
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

265814
stoichiometry: 1.0
species: 402660
type: SpeciesReference

261178
stoichiometry: 1.0
species: 406100
type: SpeciesReference

208001
units: 257862
value: 3.999888E-17
type: LocalParameter

412859
kinetic law: 273214
product: 273202
product: 273190
reactant: 273178
fast: false
reversible: false
type: Reaction

264486
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207916
units: 257862
value: 3.5998992E-16
type: LocalParameter

272462
stoichiometry: 1.0
species: 404280
type: SpeciesReference

265913
stoichiometry: 1.0
species: 402680
type: SpeciesReference

207376
units: 257775
value: 7.2E-16
type: LocalParameter

207776
units: 257862
value: 2.011824E-17
type: LocalParameter

400740
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400680
type: Species

263344
stoichiometry: 1.0
species: 400820
type: SpeciesReference

272116
stoichiometry: 1.0
species: 405700
type: SpeciesReference

402140
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

410659
kinetic law: 267792
product: 267780
product: 267768
reactant: 267756
fast: false
reversible: false
type: Reaction

264109
local parameters: 207679
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

274422
local parameters: 208216
local parameters: 208214
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

412099
kinetic law: 271369
product: 271357
product: 271345
reactant: 271333
fast: false
reversible: false
type: Reaction

258181
stoichiometry: 1.0
species: 400800
type: SpeciesReference

262654
local parameters: 207605
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

409179
kinetic law: 264205
product: 264193
product: 264181
reactant: 264169
fast: false
reversible: false
type: Reaction

266757
stoichiometry: 1.0
species: 402860
type: SpeciesReference

262501
local parameters: 207599
local parameters: 207597
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

207913
units: 257775
value: 2.16E-15
type: LocalParameter

261857
stoichiometry: 1.0
species: 406100
type: SpeciesReference

412819
kinetic law: 273118
product: 273106
product: 273094
reactant: 273082
fast: false
reversible: false
type: Reaction

261894
stoichiometry: 1.0
species: 406100
type: SpeciesReference

272423
stoichiometry: 1.0
species: 404280
type: SpeciesReference

261238
local parameters: 207534
local parameters: 207532
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

266093
local parameters: 207783
local parameters: 207781
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

207619
units: 257775
value: 7.50006E-16
type: LocalParameter

268658
local parameters: 207914
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

409139
kinetic law: 264109
product: 264097
product: 264085
reactant: 264073
fast: false
reversible: false
type: Reaction

260083
stoichiometry: 1.0
species: 405300
type: SpeciesReference

408660
kinetic law: 262896
product: 262884
reactant: 262872
reactant: 262860
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

267420
stoichiometry: 1.0
species: 403180
type: SpeciesReference

406120
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

412699
kinetic law: 272830
product: 272818
product: 272806
reactant: 272794
fast: false
reversible: false
type: Reaction

258435
stoichiometry: 1.0
species: 401680
type: SpeciesReference

261993
stoichiometry: 1.0
species: 406100
type: SpeciesReference

265451
stoichiometry: 1.0
species: 402200
type: SpeciesReference

405900
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 400680
type: Species

402180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

268333
stoichiometry: 1.0
species: 403380
type: SpeciesReference

207374
units: 257811
value: 7.2E-16
type: LocalParameter

259573
stoichiometry: 1.0
species: 404020
type: SpeciesReference

207914
units: 257775
value: 5.4E-16
type: LocalParameter

207778
units: 257775
value: 7.2E-16
type: LocalParameter

258652
stoichiometry: 1.0
species: 404180
type: SpeciesReference

407419
kinetic law: 259684
product: 259672
reactant: 259660
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true
type: Reaction

401160
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 400700
type: Species

267360
stoichiometry: 1.0
species: 402980
type: SpeciesReference

410879
kinetic law: 268369
product: 268357
product: 268345
reactant: 268333
fast: false
reversible: false
type: Reaction

264824
stoichiometry: 1.0
species: 402440
type: SpeciesReference

408619
kinetic law: 262800
product: 262788
reactant: 262776
reactant: 262764
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

207846
units: 257862
value: 3.336012E-18
type: LocalParameter

258519
stoichiometry: 1.0
species: 401520
type: SpeciesReference

208110
units: 257775
value: 1.7E-18
type: LocalParameter

270413
stoichiometry: 1.0
species: 405740
type: SpeciesReference

411439
kinetic law: 269774
product: 269762
reactant: 269750
reactant: 269738
fast: false
reversible: true
type: Reaction

207886
units: 257862
value: 3.5998992E-16
type: LocalParameter

406880
kinetic law: 258024
product: 258012
reactant: 258000
reactant: 257988
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

259975
local parameters: 207463
local parameters: 207461
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*AMPAR_memb_slash_Anchor
type: KineticLaw

273130
stoichiometry: 1.0
species: 405660
type: SpeciesReference

261907
stoichiometry: 1.0
species: 401360
type: SpeciesReference

263174
stoichiometry: 1.0
species: 402020
type: SpeciesReference

274978
stoichiometry: 1.0
species: 405040
type: SpeciesReference

404840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

263830
stoichiometry: 1.0
species: 401820
type: SpeciesReference

263806
stoichiometry: 1.0
species: 402200
type: SpeciesReference

271659
local parameters: 208070
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

207911
units: 257862
value: 3.5998992E-16
type: LocalParameter

275194
stoichiometry: 1.0
species: 405120
type: SpeciesReference

409879
kinetic law: 265900
product: 265887
reactant: 265875
reactant: 265863
fast: false
reversible: true
type: Reaction

408179
kinetic law: 261676
product: 261664
product: 261652
reactant: 261640
fast: false
reversible: false
type: Reaction

405500
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

403680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

257927
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

404000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

404360
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

413739
kinetic law: 275362
product: 275350
product: 275338
product: 275326
reactant: 275314
fast: false
reversible: false
type: Reaction

404040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

411719
kinetic law: 270450
product: 270438
reactant: 270426
reactant: 270413
fast: false
reversible: true
type: Reaction

262102
stoichiometry: 1.0
species: 401400
type: SpeciesReference

413019
kinetic law: 273599
product: 273586
product: 273574
reactant: 273562
fast: false
reversible: false
type: Reaction

265112
stoichiometry: 1.0
species: 402500
type: SpeciesReference

207771
units: 257862
value: 2.011824E-17
type: LocalParameter

410159
kinetic law: 266575
product: 266563
reactant: 266551
reactant: 266539
fast: false
reversible: true
type: Reaction

274579
stoichiometry: 1.0
species: 405620
type: SpeciesReference

408139
kinetic law: 261579
product: 261567
product: 261555
reactant: 261543
fast: false
reversible: false
type: Reaction

269714
stoichiometry: 1.0
species: 403180
type: SpeciesReference

268766
stoichiometry: 1.0
species: 405380
type: SpeciesReference

207999
units: 257775
value: 5.4E-16
type: LocalParameter

272396
stoichiometry: 1.0
species: 404520
type: SpeciesReference

261286
local parameters: 207535
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

410259
kinetic law: 266818
product: 266805
product: 266793
reactant: 266781
fast: false
reversible: false
type: Reaction

268152
stoichiometry: 1.0
species: 405260
type: SpeciesReference

260947
local parameters: 207519
local parameters: 207517
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

268080
local parameters: 207884
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

267816
stoichiometry: 1.0
species: 403180
type: SpeciesReference

207844
units: 257775
value: 1.8E-16
type: LocalParameter

411919
kinetic law: 270933
product: 270921
reactant: 270909
reactant: 270897
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true
type: Reaction

258326
stoichiometry: 1.0
species: 401720
type: SpeciesReference

273731
stoichiometry: 1.0
species: 404800
type: SpeciesReference

207884
units: 257775
value: 5.4E-16
type: LocalParameter

411799
kinetic law: 270644
product: 270631
reactant: 270619
reactant: 270607
fast: false
reversible: true
type: Reaction

263029
stoichiometry: 1.0
species: 401880
type: SpeciesReference

207998
units: 257775
value: 2.16E-15
type: LocalParameter

404720
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

274035
local parameters: 208196
local parameters: 208194
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

261421
stoichiometry: 1.0
species: 401260
type: SpeciesReference

261785
stoichiometry: 1.0
species: 405720
type: SpeciesReference

266226
stoichiometry: 1.0
species: 402200
type: SpeciesReference

207379
units: 257775
value: 1.0E-16
type: LocalParameter

404420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

259333
local parameters: 207421
local parameters: 207419
notes: kf*AC_slash_cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4
type: KineticLaw

207843
units: 257775
value: 7.2E-16
type: LocalParameter

401580
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 400680
type: Species

404760
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

260216
stoichiometry: 1.0
species: 405920
type: SpeciesReference

207883
units: 257775
value: 2.16E-15
type: LocalParameter

407180
kinetic law: 258773
product: 258761
reactant: 258749
reactant: 258737
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

207996
units: 257862
value: 3.999888E-17
type: LocalParameter

275002
local parameters: 208246
local parameters: 208244
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

207773
units: 257775
value: 7.2E-16
type: LocalParameter

411759
kinetic law: 270546
product: 270534
reactant: 270522
reactant: 270510
fast: false
reversible: true
type: Reaction

271152
stoichiometry: 1.0
species: 403960
type: SpeciesReference

273094
stoichiometry: 1.0
species: 405540
type: SpeciesReference

271586
stoichiometry: 1.0
species: 404280
type: SpeciesReference

267972
stoichiometry: 1.0
species: 403180
type: SpeciesReference

264764
stoichiometry: 1.0
species: 405200
type: SpeciesReference

264401
local parameters: 207694
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

413099
kinetic law: 273794
product: 273782
product: 273769
reactant: 273756
fast: false
reversible: false
type: Reaction

267505
stoichiometry: 1.0
species: 401800
type: SpeciesReference

267864
stoichiometry: 1.0
species: 405240
type: SpeciesReference

407719
kinetic law: 260510
product: 260498
product: 260486
reactant: 260474
fast: false
reversible: false
type: Reaction

272709
stoichiometry: 1.0
species: 405580
type: SpeciesReference

263721
local parameters: 207659
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

262800
local parameters: 207614
local parameters: 207612
notes: k1*PP1_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

264181
stoichiometry: 1.0
species: 404260
type: SpeciesReference

208177
units: 257775
value: 3.5E-18
type: LocalParameter

271502
stoichiometry: 1.0
species: 404340
type: SpeciesReference

260570
stoichiometry: 1.0
species: 400900
type: SpeciesReference

208114
units: 257775
value: 1.4E-17
type: LocalParameter

207661
units: 257862
value: 3.0024108E-17
type: LocalParameter

262628
stoichiometry: 1.0
species: 401080
type: SpeciesReference

408879
kinetic law: 263430
product: 263418
product: 263405
reactant: 263393
fast: false
reversible: false
type: Reaction

263455
stoichiometry: 1.0
species: 401980
type: SpeciesReference

263065
stoichiometry: 1.0
species: 401980
type: SpeciesReference

270522
stoichiometry: 1.0
species: 403180
type: SpeciesReference

407000
kinetic law: 258302
product: 258290
product: 258278
reactant: 258266
fast: false
reversible: true
type: Reaction

272854
stoichiometry: 1.0
species: 404280
type: SpeciesReference

267608
stoichiometry: 1.0
species: 404200
type: SpeciesReference

260838
stoichiometry: 1.0
species: 401120
type: SpeciesReference

268261
stoichiometry: 1.0
species: 403180
type: SpeciesReference

274893
stoichiometry: 1.0
species: 405060
type: SpeciesReference

266539
stoichiometry: 1.0
species: 405780
type: SpeciesReference

208176
units: 257775
value: 1.4E-17
type: LocalParameter

269605
stoichiometry: 1.0
species: 405640
type: SpeciesReference

208154
units: 257862
value: 8.7498E-18
type: LocalParameter

259792
stoichiometry: 1.0
species: 405560
type: SpeciesReference

274748
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207994
units: 257775
value: 5.4E-16
type: LocalParameter

208115
units: 257775
value: 3.5E-18
type: LocalParameter

264254
local parameters: 207688
local parameters: 207686
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

259636
stoichiometry: 1.0
species: 404100
type: SpeciesReference

407759
kinetic law: 260607
product: 260595
product: 260582
reactant: 260570
fast: false
reversible: false
type: Reaction

261092
local parameters: 207525
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

262211
local parameters: 207584
local parameters: 207582
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

264608
stoichiometry: 1.0
species: 405260
type: SpeciesReference

258374
stoichiometry: 1.0
species: 401720
type: SpeciesReference

271900
local parameters: 208084
local parameters: 208082
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

267252
local parameters: 207843
local parameters: 207841
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

267924
stoichiometry: 1.0
species: 403300
type: SpeciesReference

264716
stoichiometry: 1.0
species: 402200
type: SpeciesReference

274361
stoichiometry: 1.0
species: 404280
type: SpeciesReference

208065
units: 257775
value: 2.5E-17
type: LocalParameter

207956
units: 257862
value: 3.999888E-17
type: LocalParameter

400920
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 400680
type: Species

271225
local parameters: 208049
local parameters: 208047
notes: k1*AC_slash_cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

401800
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 400680
type: Species

264872
stoichiometry: 1.0
species: 402200
type: SpeciesReference

208008
units: 257775
value: 2.16E-15
type: LocalParameter

265052
stoichiometry: 1.0
species: 405260
type: SpeciesReference

268983
stoichiometry: 1.0
species: 403520
type: SpeciesReference

261007
stoichiometry: 1.0
species: 405640
type: SpeciesReference

267468
stoichiometry: 1.0
species: 404020
type: SpeciesReference

207889
units: 257775
value: 5.4E-16
type: LocalParameter

272310
stoichiometry: 1.0
species: 405520
type: SpeciesReference

269798
stoichiometry: 1.0
species: 405760
type: SpeciesReference

274144
stoichiometry: 1.0
species: 404880
type: SpeciesReference

266335
local parameters: 207794
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

268610
local parameters: 207913
local parameters: 207911
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

208179
units: 257862
value: 8.7498E-18
type: LocalParameter

207993
units: 257775
value: 2.16E-15
type: LocalParameter

265499
stoichiometry: 1.0
species: 402580
type: SpeciesReference

411459
kinetic law: 269822
product: 269810
product: 269798
reactant: 269786
fast: false
reversible: false
type: Reaction

207663
units: 257775
value: 2.403E-16
type: LocalParameter

275110
local parameters: 208251
local parameters: 208249
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

208112
units: 257862
value: 8.7498E-18
type: LocalParameter

412479
kinetic law: 272286
product: 272274
reactant: 272261
reactant: 272249
fast: false
reversible: true
type: Reaction

208064
units: 257775
value: 1.0E-16
type: LocalParameter

407799
kinetic law: 260703
product: 260691
product: 260679
reactant: 260667
fast: false
reversible: false
type: Reaction

208009
units: 257775
value: 5.4E-16
type: LocalParameter

263137
local parameters: 207630
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

408559
kinetic law: 262654
product: 262641
product: 262628
reactant: 262615
fast: false
reversible: false
type: Reaction

407080
kinetic law: 258495
product: 258483
reactant: 258471
reactant: 258459
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

207953
units: 257775
value: 2.16E-15
type: LocalParameter

406300
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

208152
units: 257775
value: 1.7E-18
type: LocalParameter

275314
stoichiometry: 1.0
species: 405140
type: SpeciesReference

261579
local parameters: 207550
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

265704
local parameters: 207763
local parameters: 207761
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

406180
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

405040
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 400680
type: Species

275086
stoichiometry: 1.0
species: 405040
type: SpeciesReference

207888
units: 257775
value: 2.16E-15
type: LocalParameter

411119
kinetic law: 268947
product: 268935
product: 268923
reactant: 268911
fast: false
reversible: false
type: Reaction

268839
stoichiometry: 1.0
species: 403180
type: SpeciesReference

273806
stoichiometry: 1.0
species: 405660
type: SpeciesReference

207664
units: 257775
value: 6.03E-17
type: LocalParameter

273951
stoichiometry: 1.0
species: 404840
type: SpeciesReference

401840
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

400960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

207954
units: 257775
value: 5.4E-16
type: LocalParameter

259672
stoichiometry: 1.0
species: 404140
type: SpeciesReference

410199
kinetic law: 266671
product: 266659
reactant: 266647
reactant: 266635
fast: false
reversible: true
type: Reaction

403000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 400680
type: Species

207779
units: 257775
value: 1.8E-16
type: LocalParameter

269056
stoichiometry: 1.0
species: 405420
type: SpeciesReference

208217
units: 257775
value: 3.5E-18
type: LocalParameter

405660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

413359
kinetic law: 274422
product: 274410
reactant: 274398
reactant: 274385
fast: false
reversible: true
type: Reaction

403560
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

269641
stoichiometry: 1.0
species: 405700
type: SpeciesReference

264644
local parameters: 207708
local parameters: 207706
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

207373
units: 257775
value: 0.0
type: LocalParameter

207919
units: 257775
value: 5.4E-16
type: LocalParameter

208006
units: 257862
value: 3.999888E-17
type: LocalParameter

266805
stoichiometry: 1.0
species: 402200
type: SpeciesReference

258036
stoichiometry: 1.0
species: 400960
type: SpeciesReference

208159
units: 257862
value: 8.7498E-18
type: LocalParameter

264596
local parameters: 207704
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

207430
units: 257775
value: 9.0E-17
type: LocalParameter

208062
units: 257862
value: 2.45142E-17
type: LocalParameter

270377
stoichiometry: 1.0
species: 405660
type: SpeciesReference

273574
stoichiometry: 1.0
species: 405560
type: SpeciesReference

266575
local parameters: 207808
local parameters: 207806
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

207729
units: 257775
value: 1.8E-16
type: LocalParameter

207332
units: 257862
value: 4.4999712E-15
type: LocalParameter

263879
stoichiometry: 1.0
species: 402240
type: SpeciesReference

265632
stoichiometry: 1.0
species: 405420
type: SpeciesReference

271115
stoichiometry: 1.0
species: 404080
type: SpeciesReference

258109
stoichiometry: 1.0
species: 401020
type: SpeciesReference

208118
units: 257862
value: 8.7498E-18
type: LocalParameter

268694
stoichiometry: 1.0
species: 403460
type: SpeciesReference

274784
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207991
units: 257862
value: 3.999888E-17
type: LocalParameter

402640
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 400680
type: Species

272745
stoichiometry: 1.0
species: 405520
type: SpeciesReference

402700
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

260035
stoichiometry: 1.0
species: 405320
type: SpeciesReference

401660
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700
type: Species

402680
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

207951
units: 257862
value: 3.999888E-17
type: LocalParameter

273178
stoichiometry: 1.0
species: 404680
type: SpeciesReference

407459
kinetic law: 259829
product: 259817
product: 259804
reactant: 259792
fast: false
reversible: true
type: Reaction

403520
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680
type: Species

412139
kinetic law: 271465
product: 271453
product: 271441
reactant: 271429
fast: false
reversible: false
type: Reaction

409499
kinetic law: 264980
product: 264968
product: 264956
reactant: 264944
fast: false
reversible: false
type: Reaction

408839
kinetic law: 263332
product: 263320
product: 263308
reactant: 263296
fast: false
reversible: false
type: Reaction

208219
units: 257862
value: 8.7498E-18
type: LocalParameter

413679
kinetic law: 275206
product: 275194
reactant: 275182
reactant: 275170
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

274107
stoichiometry: 1.0
species: 404280
type: SpeciesReference

207666
units: 257862
value: 3.0779838E-17
type: LocalParameter

268225
local parameters: 207893
local parameters: 207891
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

261700
stoichiometry: 1.0
species: 406100
type: SpeciesReference

207668
units: 257775
value: 1.224E-16
type: LocalParameter

266683
stoichiometry: 1.0
species: 402840
type: SpeciesReference

270123
stoichiometry: 1.0
species: 405660
type: SpeciesReference

273286
stoichiometry: 1.0
species: 405740
type: SpeciesReference

270062
local parameters: 207988
local parameters: 207986
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

208157
units: 257775
value: 1.7E-18
type: LocalParameter

207371
units: 257775
value: 4.5E-19
type: LocalParameter

208004
units: 257775
value: 5.4E-16
type: LocalParameter

259525
local parameters: 207433
local parameters: 207431
notes: kf*CaM_slash_CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM
type: KineticLaw

269918
local parameters: 207979
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

262320
stoichiometry: 1.0
species: 401440
type: SpeciesReference

260377
stoichiometry: 1.0
species: 400860
type: SpeciesReference

267530
stoichiometry: 1.0
species: 403220
type: SpeciesReference

208060
units: 257775
value: 2.5E-17
type: LocalParameter

412539
kinetic law: 272436
product: 272423
product: 272409
reactant: 272396
fast: false
reversible: false
type: Reaction

272225
stoichiometry: 1.0
species: 404280
type: SpeciesReference

259393
stoichiometry: 1.0
species: 403100
type: SpeciesReference

411059
kinetic law: 268802
product: 268790
reactant: 268778
reactant: 268766
fast: false
reversible: true
type: Reaction

262884
stoichiometry: 1.0
species: 401940
type: SpeciesReference

258761
stoichiometry: 1.0
species: 401620
type: SpeciesReference

207669
units: 257775
value: 3.06E-17
type: LocalParameter

262944
local parameters: 207620
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

207918
units: 257775
value: 2.16E-15
type: LocalParameter

260607
local parameters: 207501
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

208156
units: 257775
value: 6.8E-18
type: LocalParameter

208003
units: 257775
value: 2.16E-15
type: LocalParameter

407300
kinetic law: 259237
product: 259225
reactant: 259213
reactant: 259200
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true
type: Reaction

207370
units: 257775
value: 9.0E-17
type: LocalParameter

207728
units: 257775
value: 7.2E-16
type: LocalParameter

268947
local parameters: 207929
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

407360
kinetic law: 259525
product: 259513
reactant: 259501
reactant: 259489
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true
type: Reaction

265161
stoichiometry: 1.0
species: 402200
type: SpeciesReference

274470
local parameters: 208217
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

265961
stoichiometry: 1.0
species: 405640
type: SpeciesReference