metaid_0000071
kinetic law: 138773
modifier: 138761
product: 138749
reactant: 138737
fast: false
reversible: false
name: full AMPAR activation by active CaMKII
type: Reaction

138628
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

138640
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

138845
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

138942
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000009
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: K*
type: Species

metaid_0000091
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000003
name: Ca2plus
type: Species

metaid_0000072
kinetic law: 138821
product: 138809
reactant: 138797
reactant: 138785
fast: false
reversible: false
name: PP1 inactivation
type: Reaction

metaid_0000048
unit: 138518
name: substance
type: SBMLUnitsDef

138785
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

139223
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

138978
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000089
kinetic law: 139211
modifier: 139199
product: 139187
reactant: 139175
fast: false
reversible: false
name: intermediate AMPAR deactivation
type: Reaction

metaid_0000040
constant: true
value: 0.002
name: d2 times PKA*
type: Parameter

metaid_0000082
kinetic law: 138869
product: 138857
product: 138845
reactant: 138833
fast: false
reversible: false
name: CaM unbinding from CaMKII
type: Reaction

metaid_0000013
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D*
type: Species

metaid_0000069
kinetic law: 138688
product: 138676
reactant: 138664
fast: false
reversible: false
name: DARPP-32 activation
type: Reaction

metaid_0000034
constant: true
value: 2.17
name: k2
type: Parameter

138554
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

138713
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

138809
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000041
constant: true
value: 0.1
name: r1 times PKA*
type: Parameter

metaid_0000088
kinetic law: 139163
modifier: 139151
product: 139138
reactant: 139126
fast: false
reversible: false
name: full AMPAR activation by autophosphorylated CaMKII
type: Reaction

MODEL8938094216
species: metaid_0000006
species: metaid_0000015
parameter: metaid_0000042
parameter: metaid_0000041
type: SBMLModel
parameter: metaid_0000039
species: metaid_0000013
parameter: metaid_0000044
length unit: length
reaction: metaid_0000071
parameter: metaid_0000036
reaction: metaid_0000083
reaction: metaid_0000065
species: metaid_0000017
parameter: metaid_0000030
species: metaid_0000009
time units: 131570
reaction: metaid_0000088
reaction: metaid_0000068
reaction: metaid_0000067
species: metaid_0000007
curated: false
species: metaid_0000012
rule: metaid_0000060
parameter: metaid_0000046
parameter: metaid_0000045
reaction: metaid_0000072
substance units: metaid_0000048
parameter: metaid_0000031
species: metaid_0000010
species: metaid_0000091
parameter: metaid_0000043
units def: metaid_0000048
parameter: metaid_0000037
reaction: metaid_0000084
species: metaid_0000016
rule: metaid_0000056
species: metaid_0000008
reaction: metaid_0000089
reaction: metaid_0000069
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000034
reaction: metaid_0000082
name: dAlcantara2003_SynapticPlasticity
compartment: metaid_0000003
reaction: metaid_0000090
parameter: metaid_0000040
area units: area
reaction: metaid_0000087
species: metaid_0000011
parameter: metaid_0000032
volume units: 679943
species: metaid_0000019
parameter: metaid_0000038
reaction: metaid_0000086
reaction: metaid_0000085
parameter: metaid_0000035
is described by: http://identifiers.org/pubmed/12823459
species: metaid_0000018
species: metaid_0000059
reaction: metaid_0000070

138616
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000059
constant: true
boundary condition: false
has only substance units: false
initial concentration: 30.0
initial amount: NaN
in compartment: metaid_0000003
name: S total
type: Species

metaid_0000012
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.0
initial amount: NaN
in compartment: metaid_0000003
name: D
type: Species

metaid_0000068
kinetic law: 138652
product: 138640
reactant: 138628
reactant: 138616
fast: false
reversible: false
name: Calcineurin or PP2B activation
type: Reaction

metaid_0000039
constant: true
value: 2000.0
name: d1
type: Parameter

138954
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

138749
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000007
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000003
name: K
type: Species

138833
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000031
constant: true
value: 4.0
name: Hill coefficient
type: Parameter

138990
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

139235
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000042
constant: true
value: 1.0
name: r2
type: Parameter

metaid_0000087
kinetic law: 139114
modifier: 139102
product: 139090
reactant: 139078
fast: false
reversible: false
name: AMPAR complete deactivation by PP1
type: Reaction

139138
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000067
kinetic law: 138603
product: 138591
reactant: 138579
fast: false
reversible: false
name: CaMKII autophosphorylation
type: Reaction

metaid_0000011
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: N*
type: Species

138701
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000032
constant: true
value: 150.0
name: k1
type: Parameter

metaid_0000008
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: K'
type: Species

metaid_0000018
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: metaid_0000003
name: P*
type: Species

138664
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000043
constant: true
value: 10.0
name: r3
type: Parameter

metaid_0000010
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000003
name: N
type: Species

138530
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000085
kinetic law: 139016
modifier: 139003
product: 138990
reactant: 138978
fast: false
reversible: false
name: DARPP-32 deactivation
type: Reaction

metaid_0000037
constant: true
value: 1666.0
name: n1
type: Parameter

138797
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

139078
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000017
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: R*
type: Species

138893
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000044
constant: true
value: 0.1
name: r4
type: Parameter

metaid_0000019
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D*P
type: Species

139175
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

138737
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

138579
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

138518
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000003
constant: true
units: 679943
size: 1.0
spatial dimensions: 3.0
name: spine
type: Compartment

metaid_0000030
constant: true
value: 7.0
name: Kd
type: Parameter

metaid_0000086
kinetic law: 139066
modifier: 139054
product: 139041
reactant: 139029
fast: false
reversible: false
name: AMPAR complete deactivation by calcineurin
type: Reaction

139126
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000038
constant: true
value: 10.0
name: n2
type: Parameter

metaid_0000065
kinetic law: 138567
product: 138554
reactant: 138542
reactant: 138530
fast: false
reversible: false
name: CaMKII binding to CaM
type: Reaction

139041
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000035
constant: true
value: 0.5
name: k3
type: Parameter

metaid_0000045
constant: true
value: 0.03
name: p1
type: Parameter

metaid_0000016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: R'
type: Species

metaid_0000006
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: S*
type: Species

138676
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

138857
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

138930
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

139029
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

138591
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

138542
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000083
kinetic law: 138917
modifier: 138905
product: 138893
reactant: 138881
fast: false
reversible: false
name: CaMKII dephosphorylation
type: Reaction

metaid_0000036
constant: true
value: 0.03
name: k4
type: Parameter

139247
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000046
constant: true
value: 3.0E-5
name: p2
type: Parameter

139187
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

139090
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000090
kinetic law: 139259
product: 139247
product: 139235
reactant: 139223
fast: false
reversible: false
name: PP1 activation
type: Reaction

metaid_0000015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000003
name: R
type: Species

metaid_0000070
kinetic law: 138725
product: 138713
reactant: 138701
fast: false
reversible: false
name: AMPAR intermediate activation
type: Reaction

138881
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000084
kinetic law: 138966
product: 138954
product: 138942
reactant: 138930
fast: false
reversible: false
name: Calcineurin or PP2B inactivation
type: Reaction